{"id":55286,"date":"2018-09-28T01:00:00","date_gmt":"2018-09-30T02:03:16","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91%e6%99%9a%e6%9c%9f%e8%bd%ac%e7%a7%bbdll3%e9%ab%98sclc%e6%82%a3%e8%80%85%e4%b8%ad%e6%af%94%e8%be%83rovalpituzumab-tesirine%e5%92%8c%e6%89%98\/"},"modified":"2018-09-30T10:03:16","modified_gmt":"2018-09-30T02:03:16","slug":"%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91%e6%99%9a%e6%9c%9f%e8%bd%ac%e7%a7%bbdll3%e9%ab%98sclc%e6%82%a3%e8%80%85%e4%b8%ad%e6%af%94%e8%be%83rovalpituzumab-tesirine%e5%92%8c%e6%89%98","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/55286\/","title":{"rendered":"\u3010\u62db\u52df\u60a3\u8005\u3011\u665a\u671f\u8f6c\u79fbDLL3\u9ad8SCLC\u60a3\u8005\u4e2d\u6bd4\u8f83Rovalpituzumab tesirine\u548c\u6258\u6cca\u66ff\u5eb7\u7684\u968f\u673a\u5f00\u653e\u591a\u4e2d\u5fc33\u671f\u7814\u7a76"},"content":{"rendered":"
\n
<\/mpcps><\/section>\n

<\/span><\/span>
<\/p>\n

1.       <\/span><\/span>\u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb<\/span><\/span><\/p>\n

Rovalpituzumab Tesirine<\/span>\u662f<\/span>\u9488\u5bf9<\/span>\u03b4\u6837\u86cb\u767d<\/span>3(DLL3)\u7684\u6297\u4f53<\/span>–\u836f\u7269\u5076\u8054\u7269\u3002<\/span><\/span><\/p>\n

\u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f<\/span>\u4e00\u7ebf\u542b\u94c2\u5316\u7597\u671f\u95f4\u6216\u4e4b\u540e\u9996\u6b21\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027<\/span>DLL3<\/span>\u9ad8<\/span>SCLC<\/span>\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

2.       <\/span><\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/span><\/p>\n

\u5728\u4e00\u7ebf\u542b\u94c2\u5316\u7597\u671f\u95f4\u6216\u4e4b\u540e\u9996\u6b21\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027<\/span>DLL3<\/span>\u9ad8<\/span>SCLC<\/span>\u53d7\u8bd5\u8005\u4e2d\u8bc4\u4f30<\/span>Rovalpituzumabtesirine<\/span>\u6cbb\u7597\u4e0e\u6258\u6cca\u66ff\u5eb7\u76f8\u6bd4\u662f\u5426\u6539\u5584<\/span>ORR<\/span>\u548c<\/span>OS<\/span>\uff1b\u8bc4\u4f30<\/span>Rovalpituzumabtesirine<\/span>\u6cbb\u7597\u4e0e\u6258\u6cca\u66ff\u5eb7\u76f8\u6bd4\u662f\u5426\u6539\u5584<\/span>PFS<\/span>\uff1b\u6bd4\u8f83\u4e24\u6cbb\u7597\u7ec4\u95f4\u7684<\/span>DOR<\/span>\u548c\u5bf9\u60a3\u8005\u62a5\u544a\u7ed3\u5c40\u7684\u5f71\u54cd\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

3.       <\/span><\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u5206\u7c7b\uff1a \u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span>  <\/span><\/span><\/p>\n

\u8bd5\u9a8c\u5206\u671f\uff1a<\/span> III<\/span>\u671f<\/span><\/span><\/p>\n

\u8bbe\u8ba1\u7c7b\u578b\uff1a\u5e73\u884c\u5206\u7ec4<\/span><\/p>\n

\u968f\u673a\u5316\uff1a<\/span>     <\/span>\u968f\u673a\u5316<\/span><\/span><\/p>\n

\u76f2\u6cd5\uff1a<\/span>        <\/span>\u5f00\u653e<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u8303\u56f4\uff1a\u56fd\u9645\u591a\u4e2d\u5fc3<\/span><\/p>\n

\u8bd5\u9a8c\u4eba\u6570\uff1a\u603b\u4f53<\/span>411<\/span>\u4eba\uff0c\u4e2d\u56fd<\/span>63<\/span>\u4eba<\/span><\/span><\/p>\n

 <\/span><\/p>\n

4.       <\/span><\/span>\u5165\u9009\u6807\u51c6<\/span><\/span><\/p>\n

1  18<\/span>\u5c81\u6216\u4ee5\u4e0a\u6210\u4eba\uff0c\u5df2\u63d0\u4f9b\u4e66\u9762\u5f62\u5f0f\u7684\u77e5\u60c5\u540c\u610f\u4e66\u3002<\/span><\/span><\/p>\n

2  <\/span>\u7ecf\u7ec4\u7ec7\u5b66\u6216\u7ec6\u80de\u5b66\u786e\u8bca\u4e3a\u665a\u671f\u6216\u8f6c\u79fb\u6027<\/span>SCLC<\/span>\uff0c\u4e14\u6709\u4e00\u7ebf\u542b\u94c2\u65b9\u6848\u7cfb\u7edf\u6027\u6cbb\u7597\u671f\u95f4\u6216\u8005\u4e4b\u540e\u6709\u6587\u4ef6\u8bb0\u5f55\u7684\u9996\u6b21\u75be\u75c5\u8fdb\u5c55\u3002<\/span><\/span><\/p>\n

3  <\/span>\u80bf\u7624\u5fc5\u987b\u5b58\u5728<\/span>DLL3<\/span>\u9ad8\u8868\u8fbe\uff0c\u5b9a\u4e49\u4e3a\u6839\u636e<\/span> VENTANA DLL3<\/span>\uff08<\/span>SP347<\/span>\uff09<\/span> IHC<\/span>\u6d4b\u5b9a\uff0c\u2265<\/span> 75%<\/span>\u7684\u80bf\u7624\u7ec6\u80de\u67d3\u8272\u7ed3\u679c\u5448\u9633\u6027\u3002\u5b58\u6863\u7684\u6216\u65b0\u9c9c\u7684\u80bf\u7624\u6750\u6599\u5747\u53ef\u7528\u4e8e<\/span>DLL3<\/span>\u68c0\u6d4b\u3002<\/span><\/span><\/p>\n

4  <\/span>\u5b58\u5728\u53ef\u6d4b\u91cf\u75c5\u7076\uff0c\u7531\u4e2d\u5fc3\u5f71\u50cf\u5b66\u8bc4\u4f30\u59d4\u5458\u4f1a\uff08<\/span>CRAC<\/span>\uff09\u6309\u300a\u5b9e\u4f53\u7624\u7597\u6548\u8bc4\u4ef7\u6807\u51c6\u300b\uff08<\/span>RECIST<\/span>\uff09<\/span>1.1<\/span>\u7248\u8fdb\u884c\u786e\u5b9a\u3002<\/span><\/span><\/p>\n

5  <\/span>\u4e1c\u90e8\u80bf\u7624\u534f\u4f5c\u7ec4\uff08<\/span>ECOG<\/span>\uff09\u4f53\u80fd\u72b6\u6001\u8bc4\u5206\u4e3a<\/span>0<\/span>\u6216<\/span>1<\/span>\u3002<\/span><\/span><\/p>\n

6  <\/span>\u5177\u6709\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08<\/span>CNS<\/span>\uff09\u8f6c\u79fb\u53f2\u7684\u53d7\u8bd5\u8005\u4e0d\u5f97\u5b58\u5728\u6d3b\u52a8\u6027<\/span>CNS<\/span>\u75be\u75c5\uff0c\u5b9a\u4e49\u4e3a\u5b8c\u6210\u786e\u5207\u6027\u6cbb\u7597\uff08\u5916\u79d1\u5207\u9664\u3001<\/span>WBRT<\/span>\u6216\u7acb\u4f53\u5b9a\u5411<\/span>RT<\/span>\uff09\u540e\u81f3\u5c11<\/span>2<\/span>\u5468\u4ee5\u53ca\u968f\u673a\u5165\u7ec4\u4e4b\u524d\u4e34\u5e8a\u60c5\u51b5\u7a33\u5b9a\u6216\u6539\u5584\uff0c\u65e0\u8bba\u662f\u5426\u6b63\u5728\u4f7f\u7528\u7a33\u5b9a\u5242\u91cf\uff08\u2264<\/span>10 mg<\/span>\u6cfc\u5c3c\u677e\u6216\u6fc0\u7d20\u7b49\u6548\u5242\u91cf\uff09\u7684\u76ae\u8d28\u7c7b\u56fa\u9187\u3002\u57fa\u7ebf\u80bf\u7624\u8bc4\u4f30\u65f6\u4e0d\u5f97\u5b58\u5728\u786e\u5207\u6027\u6cbb\u7597\u540e<\/span>CNS<\/span>\u75be\u75c5\u51fa\u73b0\u8fdb\u5c55\u7684\u5f71\u50cf\u5b66\u8bc1\u636e\u3002<\/span><\/span><\/p>\n

7  <\/span>\u5f00\u59cb\u7814\u7a76\u836f\u7269\u7ed9\u836f\u524d\uff0c\u4efb\u4f55\u4e34\u5e8a\u663e\u8457\u6bd2\u6027\uff08\u4e0d\u5305\u62ec\u8131\u53d1\uff09\u5747\u6062\u590d\u81f3<\/span>0<\/span>\u7ea7\u6216<\/span>1<\/span>\u7ea7\u3002<\/span><\/span><\/p>\n

8  <\/span>\u5b9e\u9a8c\u5ba4\u53c2\u6570\u6307\u6807\u7b26\u5408\u4ee5\u4e0b\u8981\u6c42\uff1a<\/span> a. <\/span>\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\uff08<\/span>ANC<\/span>\uff09\u2265<\/span>1,500\/<\/span>\u03bc<\/span>L b. <\/span>\u8840\u5c0f\u677f\u8ba1\u6570\u2265<\/span>100,000\/<\/span>\u03bc<\/span>L c. <\/span>\u8840\u7ea2\u86cb\u767d\u2265<\/span>9.0 g\/dL d. <\/span>\u8840\u6e05\u603b\u80c6\u7ea2\u7d20\u2264<\/span>1.5<\/span>\u00d7\u6b63\u5e38\u503c\u4e0a\u9650\uff08<\/span>ULN<\/span>\uff09\u6216\u2264<\/span>3<\/span>\u00d7<\/span>ULN<\/span>\uff08\u5bf9\u4e8e<\/span>Gilbert<\/span>\u7efc\u5408\u75c7\u53d7\u8bd5\u8005\uff09<\/span> e. <\/span>\u8840\u6e05\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08<\/span>ALT<\/span>\uff09\u548c\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08<\/span>AST<\/span>\uff09\u2264<\/span>3<\/span>\u00d7<\/span>ULN<\/span>\uff08\u5982\u679c\u6709\u6076\u6027\u75be\u75c5\u809d\u810f\u53d7\u7d2f\u8bc1\u636e\uff0c\u5219\u2264<\/span>5<\/span>\u00d7<\/span>ULN<\/span>\uff09<\/span> f. <\/span>\u808c\u9150\u6e05\u9664\u7387\u2265<\/span>40mL\/min<\/span>\uff08\u4f7f\u7528<\/span>Cockroft-Gault<\/span>\u516c\u5f0f\u8ba1\u7b97\uff09\uff08\u53c2\u89c1\u9644\u5f55<\/span>G<\/span>\uff09<\/span> g. <\/span>\u767d\u86cb\u767d\u2265<\/span>3 g\/dL <\/span><\/span><\/p>\n

9  <\/span>\u5982\u679c\u662f\u5973\u6027\u53d7\u8bd5\u8005\uff0c\u5219\u5fc5\u987b\u4e3a\u7edd\u7ecf\u540e\u72b6\u6001\uff0c\u5b9a\u4e49\u4e3a\uff1a\u25cf\u5e74\u9f84\uff1e<\/span>55<\/span>\u5c81\uff0c\u4e14\u505c\u7ecf\u2265<\/span>12<\/span>\u4e2a\u6708\uff0c\u65e0\u5176\u4ed6\u533b\u5b66\u539f\u56e0\u3002\u25cf\u5e74\u9f84\u2264<\/span> 55 <\/span>\u5c81\uff0c\u4e14\u505c\u7ecf\u2265<\/span>12<\/span>\u4e2a\u6708\uff0c\u65e0\u5176\u4ed6\u533b\u5b66\u539f\u56e0\uff1b\u5e76\u4e14<\/span>FSH<\/span>\u6c34\u5e73\uff1e<\/span>40 IU\/L<\/span>\u3002\u6216\u8005\u25cf\u6c38\u4e45\u6027\u624b\u672f\u7edd\u80b2\uff08\u53cc\u4fa7\u5375\u5de2\u5207\u9664\u672f\u3001\u53cc\u4fa7\u8f93\u5375\u7ba1\u5207\u9664\u672f\u6216\u5b50\u5bab\u5207\u9664\u672f\uff09\u3002\u6216\u8005\u7b26\u5408\u4ee5\u4e0b\u6761\u4ef6\u7684\u80b2\u9f84\u671f\u5973\u6027\uff08<\/span>WOCBP<\/span>\uff09\uff1a\u4ece\u968f\u673a\u5165\u7ec4\u5f00\u59cb\u5230\u672b\u6b21\u7ed9\u4e88\u8bd5\u9a8c\u836f\u7269\u540e\u81f3\u5c11<\/span> 6 <\/span>\u4e2a\u6708\uff0c\u91c7\u7528\u81f3\u5c11\u4e00\u79cd\u65b9\u6848\u89c4\u5b9a\u7684\u8282\u80b2\u65b9\u6cd5\u3002\u5982\u679c\u7537\u6027\u53d7\u8bd5\u8005\u5904\u4e8e\u6027\u6d3b\u8dc3\u671f\uff0c\u5219\u5fc5\u987b\u540c\u610f\u4ece\u968f\u673a\u5165\u7ec4\u5f00\u59cb\u5230\u672b\u6b21\u7ed9\u4e88\u8bd5\u9a8c\u836f\u7269\u540e\u81f3\u5c11<\/span> 6 <\/span>\u4e2a\u6708\uff0c\u91c7\u7528\u65b9\u6848\u89c4\u5b9a\u7684\u8282\u80b2\u65b9\u6cd5\u3002<\/span><\/span><\/p>\n

10  <\/span>\u7b5b\u9009\u65f6\uff0c\u80b2\u9f84\u671f\u5973\u6027\u7684\u8840\u6e05\u598a\u5a20\u8bd5\u9a8c\u7ed3\u679c\u5fc5\u987b\u4e3a\u9634\u6027\uff0c\u5e76\u4e14\u968f\u673a\u5165\u7ec4\u65f6\u7684\u5c3f\u6db2\u598a\u5a20\u8bd5\u9a8c\u7ed3\u679c\u5fc5\u987b\u4e3a\u9634\u6027\u3002\u65e0\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\uff08\u7edd\u7ecf\u540e\u6216\u6c38\u4e45\u6027\u624b\u672f\u7edd\u80b2\uff09\u5728\u7b5b\u9009\u65f6\u65e0\u9700\u8fdb\u884c\u598a\u5a20\u8bd5\u9a8c\u3002<\/span><\/span><\/p>\n

11  <\/span>\u5f00\u59cb\u4efb\u4f55\u7b5b\u9009\u6216\u7279\u5b9a\u7814\u7a76\u7a0b\u5e8f\u524d\uff0c\u53d7\u8bd5\u8005\u5fc5\u987b\u81ea\u613f\u7b7e\u7f72\u72ec\u7acb\u4f26\u7406\u59d4\u5458\u4f1a\uff08<\/span>IEC<\/span>\uff09<\/span>\/<\/span>\u673a\u6784\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08<\/span>IRB<\/span>\uff09\u6279\u51c6\u7684\u77e5\u60c5\u540c\u610f\u4e66\u5e76\u6807\u660e\u65e5\u671f\uff0c\u540c\u65f6\u53d7\u8bd5\u8005\u613f\u610f\u5e76\u4e14\u786e\u5b9e\u7b26\u5408\u65b9\u6848\u89c4\u5b9a\u7684\u5404\u9879\u6307\u6807\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

5.       <\/span><\/span>\u6392\u9664\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u7814\u7a76\u8005\u6216\u7533\u529e\u8005\u8ba4\u4e3a\u53ef\u80fd\u4f7f\u53d7\u8bd5\u8005\u5904\u4e8e\u4e0d\u5fc5\u8981\u7814\u7a76\u98ce\u9669\u7684\u4efb\u4f55\u91cd\u5927\u533b\u5b66\u75c5\u75c7\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\uff0c\u672a\u5f97\u5230\u63a7\u5236\u7684\u9ad8\u8840\u538b\u548c<\/span>\/<\/span>\u6216\u7cd6\u5c3f\u75c5\u3001\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u80ba\u90e8\u75be\u75c5\u6216\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff08\u4f8b\u5982\uff0c<\/span>6<\/span>\u4e2a\u6708\u5185\u5b58\u5728\u766b\u75eb\u53d1\u4f5c\uff09\u3002<\/span><\/span><\/p>\n

2  <\/span>\u9996\u5242\u7814\u7a76\u836f\u7269\u7ed9\u836f\u524d<\/span>6<\/span>\u4e2a\u6708\u5185\u5b58\u5728\u75c5\u53f2\u8bb0\u5f55\u7684\u8111\u8840\u7ba1\u4e8b\u4ef6\uff08\u5352\u4e2d\u6216\u77ed\u6682\u6027\u8111\u7f3a\u8840\u53d1\u4f5c\uff09\u3001\u4e0d\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\u3001\u5fc3\u808c\u6897\u6b7b\u6216\u7b26\u5408\u7ebd\u7ea6\u5fc3\u810f\u75c5\u534f\u4f1a\uff08<\/span>NYHA<\/span>\uff09<\/span>III-IV<\/span>\u7ea7\u7684\u5fc3\u810f\u75c7\u72b6\u3002<\/span><\/span><\/p>\n

3  <\/span>\u5df2\u77e5\u6709\u8f6f\u8111\u819c\u8f6c\u79fb\u3002<\/span><\/span><\/p>\n

4  <\/span>\u5b64\u7acb<\/span>CNS<\/span>\u75be\u75c5\u8fdb\u5c55\uff0c\u65e0<\/span>CNS<\/span>\u4ee5\u5916\u8fdb\u5c55\u7684\u8bc1\u636e\u3002<\/span><\/span><\/p>\n

5  <\/span>\u65e2\u5f80\u91c7\u7528\u8fc7\u4e00\u79cd\u4ee5\u4e0a<\/span>SCLC<\/span>\u5168\u8eab\u6cbb\u7597\u65b9\u6848\uff08\u4f5c\u4e3a\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e00\u90e8\u5206\uff0c\u5728\u4e00\u7ebf\u542b\u94c2\u6cbb\u7597\u65b9\u6848\u4e4b\u540e\u7ed9\u4e88\u7684\u65e2\u5f80\u5168\u8eab\u6027\u7ef4\u6301\u6cbb\u7597\u662f\u5141\u8bb8\u7684\uff09\u3002<\/span><\/span><\/p>\n

6  <\/span>\u968f\u673a\u5165\u7ec4\u524d<\/span>4<\/span>\u5468\u5185\u5b58\u5728<\/span>2<\/span>\u7ea7\u6216<\/span>2<\/span>\u7ea7\u4ee5\u4e0a\u80f8\u8154\u6216\u5fc3\u5305\u79ef\u6db2\uff0c\u6216\u8005\u5b58\u5728<\/span>2<\/span>\u7ea7\u6216<\/span>2<\/span>\u7ea7\u4ee5\u4e0a\u590d\u53d1\u6027\u80f8\u8154\u6216\u5fc3\u5305\u79ef\u6db2\u65e2\u5f80\u75c5\u53f2\u9700\u8981\u6301\u7eed\u8fdb\u884c\u5fc3\u5305\u7a7f\u523a\u6216\u80f8\u8154\u7a7f\u523a\u3002<\/span><\/span><\/p>\n

7  <\/span>\u5b58\u5728\u6bdb\u7ec6\u8840\u7ba1\u6e17\u6f0f\u7efc\u5408\u5f81\u75c5\u53f2<\/span><\/span><\/p>\n

8  <\/span>\u968f\u673a\u5165\u7ec4\u524d<\/span>2<\/span>\u5468\u5185\u53d1\u751f\u4e25\u91cd\u611f\u67d3\uff0c\u5305\u62ec\u4efb\u4f55<\/span>3<\/span>\u7ea7\u6216<\/span>3<\/span>\u7ea7\u4ee5\u4e0a\uff08\u6839\u636e<\/span>4.0<\/span>\u7248<\/span>NCI CTCAE<\/span>\u8bc4\u4ef7\uff09\u7684\u75c5\u6bd2\u3001\u7ec6\u83cc\u6216\u771f\u83cc\u611f\u67d3\u3002<\/span><\/span><\/p>\n

9  <\/span>\u5973\u6027\u53d7\u8bd5\u8005\u5904\u4e8e\u598a\u5a20\u671f\u6216\u54fa\u4e73\u671f\uff0c\u6216\u8005\u8003\u8651\u5728\u7814\u7a76\u8fc7\u7a0b\u4e2d\u6216\u672b\u6b21\u7ed9\u4e88\u7814\u7a76\u836f\u7269\u540e\u7ea6<\/span>6<\/span>\u4e2a\u6708\u5185\u6000\u5b55\u3002<\/span><\/span><\/p>\n

10  <\/span>\u7537\u6027\u53d7\u8bd5\u8005\u8003\u8651\u5728\u7814\u7a76\u8fc7\u7a0b\u4e2d\u6216\u672b\u6b21\u7ed9\u4e88\u7814\u7a76\u836f\u7269\u540e\u7ea6<\/span>6<\/span>\u4e2a\u6708\u5185\u4f7f\u5176\u914d\u5076\u6000\u5b55\u6216\u6350\u732e\u7cbe\u5b50\u3002<\/span><\/span><\/p>\n

11  <\/span>\u5177\u6709<\/span>CNS<\/span>\u8f6c\u79fb\u75c5\u53f2\u7684\u53d7\u8bd5\u8005\u5728\u9996\u6b21\u7ed9\u4e88\u7814\u7a76\u836f\u7269\u4e4b\u524d<\/span>1<\/span>\u5468\u5185\u63a5\u53d7\u76ae\u8d28\u7c7b\u56fa\u9187\u7cfb\u7edf\u6027\u6cbb\u7597\uff0c\u5242\u91cf<\/span>>10 mg\/<\/span>\u5929\u6cfc\u5c3c\u677e\u6216\u6fc0\u7d20\u7b49\u6548\u5242\u91cf\u3002<\/span><\/span><\/p>\n

12  <\/span>\u53d7\u8bd5\u8005\u5728\u7814\u7a76\u5165\u7ec4\u524d<\/span>2<\/span>\u5e74\u5185\u5b58\u5728\u9664<\/span>SCLC<\/span>\u5176\u4ed6\u6d3b\u52a8\u6027\u6076\u6027\u80bf\u7624\u53f2\uff0c\u53ef\u6cbb\u6108\u7684\u539f\u4f4d\u764c\u9664\u5916\u3002<\/span><\/span><\/p>\n

13  <\/span>\u9996\u6b21\u7ed9\u4e88\u7814\u7a76\u836f\u7269\u4e4b\u524d\u5404\u6307\u5b9a\u65f6\u95f4\u6bb5\u5185\u4f7f\u7528\u4ee5\u4e0b\u4efb\u4f55\u4e00\u79cd\u6cbb\u7597\uff1a\u25cf<\/span> 2<\/span>\u5468\u5185\uff1a\u534a\u8870\u671f<\/span>< 7<\/span>\u5929\u7684\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\uff1b\u4e0d\u6d89\u53ca\u80f8\u8154\u7684\u653e\u7597\u3002\u25cf<\/span> 4<\/span>\u5468\u5185\uff1a\u5316\u7597\uff1b\u6d89\u53ca\u80f8\u8154\u7684\u653e\u7597\uff1b\u534a\u8870\u671f\u2265<\/span>7<\/span>\u5929\u7684\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\uff1b\u5355\u514b\u9686\u6297\u4f53\u3001\u6297\u4f53<\/span> – <\/span>\u836f\u7269\u5076\u8054\u7269\u3001\u653e\u5c04\u514d\u75ab\u7ed3\u5408\u7269\u6216<\/span>T<\/span>\u7ec6\u80de\u7597\u6cd5\u6216\u5176\u5b83\u7ec6\u80de\u7597\u6cd5\u3002<\/span><\/span><\/p>\n

14  <\/span>\u4efb\u4f55\u65e2\u5f80\u66b4\u9732\u4e8e\u542b\u5421\u54af\u5e76\u82ef\u5e76\u5416\u5e9a\u4e09\u70ef\uff08<\/span>PBD<\/span>\uff09\u7684\u836f\u7269\uff0c\u6216\u8005\u5df2\u77e5\u5bf9<\/span>Rovalpituzumabtesirine<\/span>\u8fc7\u654f\uff0c\u6216\u8005\u5bf9\u836f\u7269\u5236\u5242\u4e2d\u6240\u542b\u7684\u8f85\u6599\u8fc7\u654f\u3002<\/span><\/span><\/p>\n

15  <\/span>\u65e2\u5f80\u66b4\u9732\u4e8e\u6258\u6cca\u66ff\u5eb7\u3001\u4f0a\u7acb\u66ff\u5eb7\u6216\u4efb\u4f55\u5176\u4ed6\u62d3\u6251\u5f02\u6784\u9176<\/span>I<\/span>\u6291\u5236\u5242\u3002<\/span><\/span><\/p>\n

16  <\/span>\u5148\u524d\u53c2\u52a0\u8fc7\u4f7f\u7528<\/span>Rovalpituzumabtesirine<\/span>\u4f5c\u4e3a\u7814\u7a76\u836f\u7269\u7684\u7814\u7a76\u3002<\/span><\/span><\/p>\n

17  <\/span>\u5df2\u77e5\u5bf9\u4ece\u4e2d\u56fd\u4ed3\u9f20\u5375\u5de2\u7ec6\u80de\u4e2d\u751f\u4ea7\u7684\u751f\u7269\u5236\u54c1\u8fc7\u654f\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

6.       <\/span><\/span>\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/span><\/p>\n

\u4e3b\u8981\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/p>\n\n\n\n\n\n
\n

\u59d3\u540d <\/span><\/p>\n<\/td>\n

\n

\u7a0b\u9896\uff0c\u533b\u5b66\u5b66\u58eb <\/span><\/p>\n<\/td>\n

\n

\u804c\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e3b\u4efb\u533b\u5e08 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u90ae\u653f\u5730\u5740 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u5409\u6797\u7701\u957f\u6625\u5e02\u6e56\u5149\u8def1018\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u90ae\u7f16 <\/span><\/p>\n<\/td>\n

\n

130012 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5355\u4f4d\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u5409\u6797\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n

\u5404\u53c2\u52a0\u673a\u6784\u4fe1\u606f<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u5e8f\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u673a\u6784\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u7814\u7a76\u8005 <\/span><\/p>\n<\/td>\n

\n

\u56fd\u5bb6 <\/span><\/p>\n<\/td>\n

\n

\u7701\uff08\u5dde\uff09 <\/span><\/p>\n<\/td>\n

\n

\u57ce\u5e02 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1 <\/span><\/p>\n<\/td>\n

\n

\u5409\u6797\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u7a0b\u9896 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5409\u6797 <\/span><\/p>\n<\/td>\n

\n

\u957f\u6625 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2 <\/span><\/p>\n<\/td>\n

\n

\u897f\u5b89\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u7b2c\u4e00\u9644\u5c5e\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u59da\u715c <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u9655\u897f <\/span><\/p>\n<\/td>\n

\n

\u897f\u5b89 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

3 <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u5468\u5efa\u82f1 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f <\/span><\/p>\n<\/td>\n

\n

\u676d\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

4 <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u4f59\u65b0\u6c11 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f <\/span><\/p>\n<\/td>\n

\n

\u676d\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

5 <\/span><\/p>\n<\/td>\n

\n

\u90d1\u5dde\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u674e\u9192\u538b <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6cb3\u5357 <\/span><\/p>\n<\/td>\n

\n

\u90d1\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

6 <\/span><\/p>\n<\/td>\n

\n

\u65b0\u7586\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u5218\u6625\u73b2 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u65b0\u7586 <\/span><\/p>\n<\/td>\n

\n

\u4e4c\u9c81\u6728\u9f50 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

7 <\/span><\/p>\n<\/td>\n

\n

\u7b2c\u56db\u519b\u533b\u5927\u5b66\u7b2c\u4e8c\u9644\u5c5e\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u5f20\u8d3a\u9f99 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u9655\u897f <\/span><\/p>\n<\/td>\n

\n

\u897f\u5b89 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

8 <\/span><\/p>\n<\/td>\n

\n

\u6cb3\u5357\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u738b\u542f\u9e23 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6cb3\u5357 <\/span><\/p>\n<\/td>\n

\n

\u90d1\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

9 <\/span><\/p>\n<\/td>\n

\n

\u6cb3\u5357\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u80e1\u79c0\u5cf0 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6cb3\u5357 <\/span><\/p>\n<\/td>\n

\n

\u90d1\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

10 <\/span><\/p>\n<\/td>\n

\n

\u4e91\u5357\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u6768\u6da6\u7965 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u4e91\u5357 <\/span><\/p>\n<\/td>\n

\n

\u6606\u660e <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

11 <\/span><\/p>\n<\/td>\n

\n

\u798f\u5efa\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u9ec4\u8bda <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u798f\u5efa <\/span><\/p>\n<\/td>\n

\n

\u798f\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

12 <\/span><\/p>\n<\/td>\n

\n

\u798f\u5efa\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u534f\u548c\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u6768\u5347 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u798f\u5efa <\/span><\/p>\n<\/td>\n

\n

\u798f\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

13 <\/span><\/p>\n<\/td>\n

\n

\u6e56\u5357\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u90ac\u9e9f <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6e56\u5357 <\/span><\/p>\n<\/td>\n

\n

\u957f\u6c99 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

14 <\/span><\/p>\n<\/td>\n

\n

\u5357\u4eac\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u90ed\u4eba\u82b1 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6c5f\u82cf <\/span><\/p>\n<\/td>\n

\n

\u5357\u4eac <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

15 <\/span><\/p>\n<\/td>\n

\n

\u54c8\u5c14\u6ee8\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u9648\u516c\u8a00 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u9ed1\u9f99\u6c5f <\/span><\/p>\n<\/td>\n

\n

\u54c8\u5c14\u6ee8 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

16 <\/span><\/p>\n<\/td>\n

\n

\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u4e2d\u5c71\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u80e1\u6d01 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

NA <\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

199 <\/span><\/p>\n<\/td>\n

\n

\u6e56\u5317\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u80e1\u8273\u840d <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6e56\u5317 <\/span><\/p>\n<\/td>\n

\n

\u6b66\u6c49 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n

\u672c\u8bd5\u9a8c\u4fe1\u606f\u6765\u81ea<\/span>CFDA<\/span>\u201c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u516c\u793a\u5e73\u53f0\u201d\u3002<\/span><\/span><\/p>\n

\u6b22\u8fce\u7533\u529e\u65b9\/CRO\/\u533b\u9662\u63d0\u4f9b\u80bf\u7624\u62db\u52df\u4fe1\u606f\uff0c\u53ef\u4ee5\u53d1\u90ae\u4ef6\u81f3LCSYZMXX@163.com\uff0c\u672c\u516c\u4f17\u53f7\u514d\u8d39\u63a8\u9001\u3002<\/span><\/p>\n

\n


<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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