{"id":55292,"date":"2018-09-26T01:00:00","date_gmt":"2018-09-30T02:03:22","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91b002%e6%b2%bb%e7%96%97her2%e9%98%b3%e6%80%a7%e7%9a%84%e5%a4%8d%e5%8f%91%e6%80%a7%e6%88%96%e8%bd%ac%e7%a7%bb%e6%80%a7%e4%b9%b3%e8%85%ba%e7%99%8c\/"},"modified":"2018-09-30T10:03:23","modified_gmt":"2018-09-30T02:03:23","slug":"%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91b002%e6%b2%bb%e7%96%97her2%e9%98%b3%e6%80%a7%e7%9a%84%e5%a4%8d%e5%8f%91%e6%80%a7%e6%88%96%e8%bd%ac%e7%a7%bb%e6%80%a7%e4%b9%b3%e8%85%ba%e7%99%8c","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/55292\/","title":{"rendered":"\u3010\u62db\u52df\u60a3\u8005\u3011B002\u6cbb\u7597HER2\u9633\u6027\u7684\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u53ca\u7597\u6548\u521d\u6b65\u63a2\u7d22"},"content":{"rendered":"
\n
<\/mpcps><\/section>\n

<\/span><\/span>
<\/p>\n

1.       <\/span><\/span>\u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb<\/span><\/span><\/p>\n

B002<\/span>\u662f\u6ce8\u5c04\u7528\u91cd\u7ec4\u6297<\/span>HER2<\/span>\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u7ec4\u5408\u7269\u3002<\/span><\/span><\/p>\n

\u672c\u8bd5\u9a8c\u9002\u5e94\u75c7\u662f<\/span>HER2<\/span>\u9633\u6027\u7684\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

2.       <\/span><\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/span><\/p>\n

\u4e3b\u8981\u76ee\u7684\u8bc4\u4f30<\/span>B002<\/span>\u5728<\/span>HER2<\/span>\u9633\u6027\u7684\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7279\u5f81\u3002\u8bc4\u4f30\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08<\/span>DLT<\/span>\uff09\u5e76\u63a2\u7d22\u6700\u5927\u8010\u53d7\u5242\u91cf\uff08<\/span>MTD<\/span>\uff09\u3002<\/span> <\/span><\/span><\/p>\n

\u6b21\u8981\u76ee\u7684\u8bc4\u4ef7<\/span>B002<\/span>\u5404\u7ec4\u4efd\u5728<\/span>HER2<\/span>\u9633\u6027\u7684\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u5355\u6b21\u53ca\u591a\u6b21\u7528\u836f\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff1b\u514d\u75ab\u539f\u6027\uff1b\u521d\u6b65\u63a2\u7d22<\/span>B002<\/span>\u5728<\/span>HER2<\/span>\u9633\u6027\u7684\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u591a\u6b21\u7528\u836f\u7684\u6709\u6548\u6027\uff0c\u89c2\u5bdf\u5ba2\u89c2\u7f13\u89e3\u7387\uff08<\/span>ORR<\/span>\uff09\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

3.       <\/span><\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u5206\u7c7b\uff1a<\/span>   <\/span>\u5176\u4ed6<\/span><\/span><\/p>\n

 <\/span>\u8bd5\u9a8c\u5206\u671f\uff1a<\/span>  I<\/span>\u671f<\/span><\/span><\/p>\n

 <\/span>\u8bbe\u8ba1\u7c7b\u578b\uff1a<\/span>  <\/span>\u5355\u81c2\u8bd5\u9a8c<\/span><\/span><\/p>\n

 <\/span>\u968f\u673a\u5316\uff1a<\/span>      <\/span>\u975e\u968f\u673a\u5316<\/span><\/span><\/p>\n

 <\/span>\u76f2\u6cd5\uff1a<\/span>          <\/span>\u5f00\u653e<\/span><\/span><\/p>\n

 <\/span>\u8bd5\u9a8c\u8303\u56f4\uff1a<\/span>  <\/span>\u56fd\u5185\u8bd5\u9a8c<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u4eba\u6570\uff1a<\/span>  19-22<\/span><\/span><\/p>\n

 <\/span><\/p>\n

4.       <\/span><\/span>\u5165\u9009\u6807\u51c6<\/span><\/span><\/p>\n

1  18<\/span>\u5c81\u2264\u5e74\u9f84\u2264<\/span>70<\/span>\u5c81\u3001\u5973\u6027\uff1b<\/span><\/span><\/p>\n

2  BMI 18<\/span>\uff5e<\/span>32kg\/m2<\/span>\uff0c\u542b\u4e24\u7aef\uff1b<\/span><\/span><\/p>\n

3  <\/span>\u7ec4\u7ec7\u5b66\u6216\u7ec6\u80de\u5b66\u8bc1\u5b9e\u7684\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u3002\u4f9d\u636e<\/span>RECISTv 1.1<\/span>\uff0c\u5177\u6709\u53ef\u6d4b\u91cf\u548c<\/span>\/<\/span>\u6216\u4e0d\u53ef\u6d4b\u91cf\u75c5\u7076\u7684\u60a3\u8005\uff1a<\/span>1) <\/span>\u4ec5\u6709\u9aa8\u8f6c\u79fb\u7684\u60a3\u8005\uff0c\u53ea\u8981\u9aa8\u8f6c\u79fb\u75c5\u7076\u4ece\u672a\u63a5\u53d7\u8fc7\u653e\u7597\uff0c\u5e76\u4e14\u53ef\u83b7\u5f97\u539f\u53d1\u7076\u7684\u80bf\u7624\u8721\u5757\u8fdb\u884c<\/span>HER2<\/span>\u68c0\u6d4b\u548c\u751f\u7269\u6807\u8bb0\u7269\u5206\u6790\uff0c\u5373\u53ef\u4ee5\u5165\u7ec4\uff1b<\/span>2) <\/span>\u5c40\u90e8\u590d\u53d1\u4e14\u4e0d\u9002\u5408\u8fdb\u884c\u4e73\u817a\u6839\u6cbb\u5207\u9664\u672f\u7684\u60a3\u8005\uff1b<\/span>3) <\/span>\u5bf9\u4e8e\u53cc\u4fa7\u4e73\u817a\u764c\uff0c\u4e14\u53cc\u4fa7<\/span>HER2<\/span>\u8868\u8fbe\u4e0d\u4e00\u81f4\u8005\uff0c\u9700\u8bc1\u5b9e\u8f6c\u79fb\u7076\u4e3a<\/span>HER2<\/span>\u9633\u6027\uff1b<\/span><\/span><\/p>\n

4  <\/span>\u9488\u5bf9\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u75be\u75c5\u6297<\/span>HER2<\/span>\u6cbb\u7597\u5931\u8d25\u8005\uff1b<\/span><\/span><\/p>\n

5  <\/span>\u7ecf\u672c\u4e2d\u5fc3\u75c5\u7406\u79d1\u8bca\u65ad\uff0c\u786e\u8bca\u4e3a<\/span>HER2<\/span>\u9633\u6027\uff08<\/span>FISH<\/span>\u9633\u6027\u548c<\/span>\/<\/span>\u6216<\/span>IHC3+<\/span>\uff09\u7684\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff1b<\/span><\/span><\/p>\n

6  <\/span>\u57fa\u7ebf\u671f\uff08\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u524d<\/span>28<\/span>\u5929\u5185\uff09\u7ecf\u8d85\u58f0\u5fc3\u52a8\u56fe\uff08<\/span>ECHO<\/span>\uff09\u68c0\u6d4b\u5de6\u5ba4\u5c04\u8840\u5206\u6570\uff08<\/span>LVEF<\/span>\uff09\u2265<\/span>50%<\/span>\uff1b<\/span><\/span><\/p>\n

7  ECOG <\/span>\u4f53\u529b\u72b6\u6001\uff08<\/span>PS<\/span>\uff09\u4e3a<\/span>0-1<\/span>\u5206\uff1b<\/span><\/span><\/p>\n

8  <\/span>\u9884\u671f\u751f\u5b58<\/span>3<\/span>\u4e2a\u6708\u4ee5\u4e0a\uff1b<\/span><\/span><\/p>\n

9  <\/span>\u80b2\u9f84\u671f\u7684\u5973\u6027\u60a3\u8005\uff0c\u60a3\u8005\u548c<\/span>\/<\/span>\u6216\u5176\u4f34\u4fa3\u5e94\u540c\u610f\u4f7f\u7528\u4e00\u79cd\u9ad8\u6548\u7684\u975e\u6fc0\u7d20\u907f\u5b55\u65b9\u6cd5\u6216\u8005\u4e24\u79cd\u6709\u6548\u7684\u975e\u6fc0\u7d20\u907f\u5b55\u65b9\u6cd5\u3002\u5e76\u5728\u7814\u7a76\u6cbb\u7597\u671f\u95f4\u548c\u672b\u6b21\u7528\u836f\u540e\u81f3\u5c11<\/span>6<\/span>\u4e2a\u6708\u5185\u7ee7\u7eed\u4f7f\u7528\u76f8\u5e94\u7684\u907f\u5b55\u63aa\u65bd\uff1b<\/span><\/span><\/p>\n

10  <\/span>\u7406\u89e3\u5e76\u81ea\u613f\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\u3002<\/span><\/span><\/p>\n

\n


<\/span><\/span><\/p>\n

5.       <\/span><\/span>\u6392\u9664\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u7b26\u5408\u4e0b\u5217\u6807\u51c6\u4e2d\u4efb\u4f55\u4e00\u9879\u7684\u53d7\u8bd5\u8005\u5747\u4e0d\u80fd\u53c2\u52a0\u7814\u7a76\uff1a<\/span>1.<\/span>\u65e2\u5f80\u66fe\u4f7f\u7528\u8fc7\u5e15\u59a5\u73e0\u5355\u6297\uff1b<\/span><\/span><\/p>\n

2  <\/span>\u5728\u7b5b\u9009\u68c0\u67e5\u65f6\uff0c\u65e2\u5f80\u4f7f\u7528\u8fc7\u66f2\u59a5\u73e0\u5355\u6297\u7684\u60a3\u8005\u8840\u836f\u6d53\u5ea6\u2265<\/span>5<\/span>\u03bc<\/span>g\/ml<\/span>\uff1b<\/span><\/span><\/p>\n

3  <\/span>\u5df2\u77e5\u5bf9\u7814\u7a76\u836f\u7269\u6216\u5176\u7ec4\u4efd\u8fc7\u654f\uff1b<\/span><\/span><\/p>\n

4  <\/span>\u65e2\u5f80\u6709\u9020\u5f71\u5242\u8fc7\u654f\u53f2\u7684\u53d7\u8bd5\u8005\uff1b<\/span><\/span><\/p>\n

5  <\/span>\u6709\u4e34\u5e8a\u6216\u653e\u5c04\u79d1\u8bc1\u636e\u8868\u660e\u5b58\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08<\/span>CNS<\/span>\uff09\u8f6c\u79fb\u3002\u5bf9\u4e8e\u4e34\u5e8a\u7591\u4f3c<\/span>CNS<\/span>\u8f6c\u79fb\u7684\u60a3\u8005\uff0c\u968f\u673a\u524d<\/span>28<\/span>\u5929\u5185\u5fc5\u987b\u8fdb\u884c\u589e\u5f3a<\/span>CT<\/span>\u6216\u589e\u5f3a<\/span>MRI<\/span>\u68c0\u67e5\uff0c\u6392\u9664<\/span>CNS<\/span>\u8f6c\u79fb\uff1b<\/span><\/span><\/p>\n

6  <\/span>\u56e0\u65e2\u5f80\u6cbb\u7597\u6240\u5f15\u8d77\u7684\u8840\u6db2\u5b66\u6bd2\u6027\u53cd\u5e94<\/span>CTCAE<\/span>\u2265<\/span>2<\/span>\u7ea7\u6301\u7eed\u5b58\u5728\uff08\u9664\u5916\u8840\u7ea2\u86cb\u767d\uff09\uff08<\/span>NCI-CTCAE4.03<\/span>\u7248\uff09\uff1b<\/span><\/span><\/p>\n

7  <\/span>\u5b58\u5728\u5916\u5468\u795e\u7ecf\u75c5\u53d8<\/span>CTCAE<\/span>\u2265<\/span>3<\/span>\u7ea7\uff08\u7b2c<\/span>1<\/span>\u5242\u91cf\u7ec4\uff0c\u5916\u5468\u795e\u7ecf\u75c5\u53d8<\/span>CTCAE<\/span>\u2265<\/span>2<\/span>\u7ea7\uff09\uff1b<\/span><\/span><\/p>\n

8  <\/span>\u6700\u8fd1<\/span>5<\/span>\u5e74\u5185\u6709\u5176\u5b83\u6076\u6027\u80bf\u7624\u53f2\uff0c\u9664\u5916\u5df2\u6cbb\u6108\u7684\u5b50\u5bab\u9888\u539f\u4f4d\u764c\u6216\u57fa\u5e95\u7ec6\u80de\u764c\u6216\u76ae\u80a4\u9cde\u72b6\u7ec6\u80de\u764c\uff1b<\/span><\/span><\/p>\n

9  <\/span>\u672a\u80fd\u63a7\u5236\u7684\u9ad8\u8840\u538b\uff08\u6536\u7f29\u538b\u5927\u4e8e<\/span>150mmHg<\/span>\u548c<\/span>\/<\/span>\u6216\u8212\u5f20\u538b\u5927\u4e8e<\/span>100mmHg<\/span>\uff09\uff0c\u4f53\u4f4d\u6027\u4f4e\u8840\u538b\uff1b<\/span><\/span><\/p>\n

10  <\/span>\u5fc3\u810f\u6807\u51c6\uff1a<\/span>QTc<\/span>\uff1e<\/span>480ms<\/span>\u3002\u5b58\u5728\u53ef\u5bfc\u81f4<\/span>QTc<\/span>\u5ef6\u957f\u6216\u5fc3\u5f8b\u5931\u5e38\u7684\u56e0\u7d20\u5982\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u3001\u4f4e\u94be\u8840\u75c7\u3001\u957f<\/span>QT<\/span>\u7efc\u5408\u5f81\uff08\u623f\u98a4\uff0c\u9635\u53d1\u6027\u5ba4\u4e0a\u6027\u5fc3\u52a8\u8fc7\u901f\u9664\u5916\uff09\u3002\u5b58\u5728\u4efb\u4f55\u4e0d\u7a33\u5b9a\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\uff08\u5305\u62ec\u7ebd\u7ea6\u5fc3\u810f\u75c5\u5b66\u4f1a<\/span>NYHA<\/span>\u5fc3\u529f\u80fd\u5206\u7ea7\u8fbe\u2162\u6216\u2163\u7ea7\u3001\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u3001\u4e0d\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\u3001<\/span>6<\/span>\u4e2a\u6708\u5185\u6709\u5fc3\u808c\u6897\u585e\u75c5\u53f2\uff09\uff1b<\/span><\/span><\/p>\n

11  <\/span>\u65e2\u5f80\u6ce8\u5c04\u7528\u66f2\u59a5\u73e0\u5355\u6297\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u6cbb\u7597\u671f\u95f4\u6216\u6cbb\u7597\u7ed3\u675f\u4e4b\u540e\uff0c<\/span>LVEF<\/span>\uff1c<\/span>50%<\/span>\uff1b<\/span><\/span><\/p>\n

12  <\/span>\u7531\u665a\u671f\u6076\u6027\u80bf\u7624\u5e76\u53d1\u75c7\u5f15\u8d77\u7684\u9759\u606f\u65f6\u547c\u5438\u56f0\u96be\uff0c\u6216\u5176\u5b83\u9700\u8981\u6301\u7eed\u6c27\u7597\u7684\u75be\u75c5\uff1b<\/span><\/span><\/p>\n

13  <\/span>\u5b58\u5728\u4e25\u91cd\u7684\u3001\u4e0d\u80fd\u63a7\u5236\u7684\u7cfb\u7edf\u6027\u75be\u75c5\uff08\u5982\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5fc3\u8840\u7ba1\u3001\u80ba\u3001\u809d\u80be\u3001\u6d88\u5316\u9053\u6216\u4ee3\u8c22\u75be\u75c5\uff1b\u9aa8\u6298\uff09\uff1b<\/span><\/span><\/p>\n

14  <\/span>\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u524d<\/span>28<\/span>\u5929\u5185\u7ecf\u5386\u91cd\u5927\u624b\u672f\u6216\u5916\u4f24\uff0c\u6216\u5728\u7814\u7a76\u6cbb\u7597\u7ed3\u675f\u4e4b\u524d\u8ba1\u5212\u8fdb\u884c\u5927\u624b\u672f\uff1b<\/span><\/span><\/p>\n

15  <\/span>\u57fa\u7ebf\u671f\uff08\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u524d<\/span>28<\/span>\u5929\u5185\uff09\u8fdb\u884c\u84bd\u73af\u7c7b\u6297\u751f\u7d20\u7d2f\u79ef\u5242\u91cf\u8bc4\u4f30\uff0c\u8fbe\u5230\u4ee5\u4e0b\u6807\u51c6\u8005\uff1a<\/span>– <\/span>\u963f\u9709\u7d20\uff1e<\/span>360mg\/m2<\/span>\uff1b<\/span>– <\/span>\u8868\u67d4\u6bd4\u661f\uff1e<\/span>720mg\/m2<\/span>\uff1b<\/span>– <\/span>\u76d0\u9178\u7c73\u6258\u84bd\u918c\uff1e<\/span>120mg\/m2<\/span>\u548c\u4f0a\u8fbe\u6bd4\u661f\uff08\u53bb\u7532\u6c27\u57fa\u67d4\u7ea2\u9709\u7d20\uff09\uff1e<\/span>90mg\/m2<\/span>\uff1b<\/span>– <\/span>\u5176\u5b83\uff08\u5982\u591a\u67d4\u6bd4\u661f\u8102\u8d28\u4f53\u6216\u5176\u5b83\u84bd\u73af\u7c7b\u6297\u751f\u7d20\uff1e<\/span>360mg\/m2<\/span>\u7684\u963f\u9709\u7d20\u7b49\u6548\u5242\u91cf\uff09\uff1b<\/span>– <\/span>\u5982\u679c\u4f7f\u7528\u4e00\u79cd\u4ee5\u4e0a\u84bd\u73af\u7c7b\u6297\u751f\u7d20\uff0c\u90a3\u4e48\u5176\u7d2f\u79ef\u5242\u91cf\u4e0d\u80fd\u8d85\u8fc7<\/span>360mg\/m2<\/span>\u7684\u963f\u9709\u7d20\u7b49\u6548\u5242\u91cf\uff1b<\/span><\/span><\/p>\n

16  <\/span>\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u524d<\/span>28<\/span>\u5929\u5185\u66fe\u63a5\u53d7\u8fc7\u4efb\u4f55\u8bd5\u9a8c\u7528\u836f\u7684\u6cbb\u7597\uff1b<\/span><\/span><\/p>\n

17  <\/span>\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u524d<\/span>28<\/span>\u5929\u5185\u66fe\u63a5\u53d7\u8fc7\u4efb\u4f55\u6cbb\u7597\u7528\u6297\u4f53\u6216\u75ab\u82d7\uff1b<\/span><\/span><\/p>\n

18  <\/span>\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u524d<\/span>28<\/span>\u5929\u5185\u66fe\u63a5\u53d7\u8fc7\u5316\u7597\u3001\u5185\u5206\u6ccc\u6cbb\u7597\u3001\u653e\u7597\uff1b<\/span><\/span><\/p>\n

19  <\/span>\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u524d<\/span>14<\/span>\u5929\u5185\u63a5\u53d7\u8fc7\u9759\u8109\u5185\u8f93\u6ce8\u6297\u751f\u7d20\u6cbb\u7597\u611f\u67d3\uff1b<\/span><\/span><\/p>\n

20  <\/span>\u9700\u6bcf\u65e5\u53e3\u670d\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\uff0c\u76f8\u5f53\u4e8e\u5242\u91cf\uff1e<\/span>10mg\/<\/span>\u5929\u7684\u7532\u5f3a\u9f99\uff0c\u5438\u5165\u6027\u76ae\u8d28\u6fc0\u7d20\u9664\u5916\uff1b<\/span><\/span><\/p>\n

21  <\/span>\u5b58\u5728\u9488\u5bf9\u66f2\u59a5\u73e0\u5355\u6297\u7684\u6297\u836f\u7269\u6297\u4f53\uff1b<\/span><\/span><\/p>\n

22  <\/span>\u5f00\u59cb\u8bd5\u9a8c\u7528\u836f\u524d<\/span>7<\/span>\u5929\u5185\uff0c\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u7ed3\u679c\u53d1\u73b0\u4e0b\u5217\u4efb\u4f55\u4e00\u9879\u5f02\u5e38\uff1a<\/span>– <\/span>\u4e2d\u6027\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\uff1c<\/span>1.5<\/span>\u00d7<\/span>109\/L- <\/span>\u8840\u5c0f\u677f\u8ba1\u6570\uff1c<\/span>80.0<\/span>\u00d7<\/span>109\/L- <\/span>\u8840\u7ea2\u86cb\u767d\uff1c<\/span>9g\/dL – <\/span>\u603b\u80c6\u7ea2\u7d20\uff1e<\/span>1.5<\/span>\u00d7\u6b63\u5e38\u4e0a\u9650\uff08<\/span>ULN<\/span>\uff09\uff08\u9664\u975e\u60a3\u8005\u6709<\/span>Glibert<\/span>\u2019<\/span>s<\/span>\u7efc\u5408\u75c7\uff09<\/span>– AST<\/span>\u6216<\/span>ALT<\/span>\uff1e<\/span>2.5<\/span>\u00d7<\/span>ULN- <\/span>\u808c\u9150\u6e05\u9664\u7387\uff08\u7528<\/span>Cockcroft_Gault<\/span>\u516c\u5f0f\u8ba1\u7b97\uff09\uff1c<\/span>50 mL\/min – <\/span>\u56fd\u9645\u6807\u51c6\u5316\u6bd4\u7387\uff08<\/span>INR<\/span>\uff09\u548c\u6d3b\u5316\u90e8\u5206\u51dd\u8840\u6fc0\u9176\u65f6\u95f4\u6216\u90e8\u5206\u51dd\u8840\u6fc0\u9176\u65f6\u95f4\uff08<\/span>APPT<\/span>\u6216<\/span>PT<\/span>\uff09\uff1e<\/span>1.5<\/span>\u00d7<\/span>ULN(<\/span>\u9664\u975e\u662f\u6cbb\u7597\u5f15\u8d77\u7684\u51dd\u8840\u5f02\u5e38<\/span>)<\/span>\uff1b<\/span><\/span><\/p>\n

23  <\/span>\u4e59\u809d\u8868\u9762\u6297\u539f\u9633\u6027\u4e14<\/span>HBV-DNA<\/span>\u68c0\u6d4b\u2265\u68c0\u6d4b\u4e0b\u9650\uff1b\u4e19\u809d\u6297\u4f53\u9633\u6027\uff1b<\/span>HIV<\/span>\u6297\u4f53\u9633\u6027\uff1b<\/span><\/span><\/p>\n

24  <\/span>\u598a\u5a20\u6216\u54fa\u4e73\u671f\u5987\u5973\uff1b<\/span><\/span><\/p>\n

25  <\/span>\u7814\u7a76\u8005\u5224\u65ad\u7684\u5176\u4ed6\u4e0d\u9002\u5b9c\u53c2\u52a0\u672c\u7814\u7a76\u7684\u60c5\u51b5\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

6.       <\/span><\/span>\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/span><\/p>\n\n\n\n\n\n
\n

\u59d3\u540d <\/span><\/p>\n<\/td>\n

\n

\u80e1\u5915\u6625 <\/span><\/p>\n<\/td>\n

\n

\u804c\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e3b\u4efb\u533b\u5e08 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u90ae\u653f\u5730\u5740 <\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77\u5e02\u5f90\u6c47\u533a\u4e1c\u5b89\u8def270\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u90ae\u7f16 <\/span><\/p>\n<\/td>\n

\n

200032 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5355\u4f4d\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n

\u672c\u8bd5\u9a8c\u4fe1\u606f\u6765\u81ea\u7533\u529e\u65b9\u3002<\/span><\/p>\n

\u6b22\u8fce\u7533\u529e\u65b9\/CRO\/\u533b\u9662\u63d0\u4f9b\u80bf\u7624\u62db\u52df\u4fe1\u606f\uff0c\u53ef\u4ee5\u53d1\u90ae\u4ef6\u81f3LCSYZMXX@163.com\uff0c\u672c\u516c\u4f17\u53f7\u514d\u8d39\u63a8\u9001\u3002<\/span><\/p>\n

\n


<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

1.       \u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb B002\u662f\u6ce8\u5c04\u7528\u91cd […]<\/p>\n","protected":false},"author":1,"featured_media":55293,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/55292"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=55292"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/55292\/revisions"}],"predecessor-version":[{"id":55294,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/55292\/revisions\/55294"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/55293"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=55292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=55292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=55292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}