{"id":55748,"date":"2018-09-29T01:00:00","date_gmt":"2018-09-30T02:08:22","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e7%82%8e%e7%97%87%e8%af%b1%e5%af%bc%e7%99%8c%e7%97%87%e5%a4%8d%e5%8f%91%ef%bc%9fscience%e6%8f%ad%e7%a4%ba%ef%bc%9a%e5%94%a4%e9%86%92%e4%bc%91%e7%9c%a0%e7%99%8c%e7%bb%86%e8%83%9e%e7%9a%84%e4%bf%a1\/"},"modified":"2018-09-30T10:08:24","modified_gmt":"2018-09-30T02:08:24","slug":"%e7%82%8e%e7%97%87%e8%af%b1%e5%af%bc%e7%99%8c%e7%97%87%e5%a4%8d%e5%8f%91%ef%bc%9fscience%e6%8f%ad%e7%a4%ba%ef%bc%9a%e5%94%a4%e9%86%92%e4%bc%91%e7%9c%a0%e7%99%8c%e7%bb%86%e8%83%9e%e7%9a%84%e4%bf%a1","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/55748\/","title":{"rendered":"\u708e\u75c7\u8bf1\u5bfc\u764c\u75c7\u590d\u53d1\uff1fScience\u63ed\u793a\uff1a\u5524\u9192\u4f11\u7720\u764c\u7ec6\u80de\u7684\u4fe1\u53f7"},"content":{"rendered":"
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\u6297\u764c\u5e38\u88ab\u6bd4\u4f5c\u6253\u5730\u9f20\u6e38\u620f\uff0c\u56e0\u4e3a\u5373\u4f7f\u764c\u75c7\u6cbb\u7597\u6210\u529f\uff0c\u539f\u53d1\u80bf\u7624\u4e2d\u4f11\u7720\u548c\u672a\u5206\u88c2\u7684\u764c\u7ec6\u80de\u4ecd\u53ef\u80fd\u5b58\u5728\u4e8e\u8eab\u4f53\u5176\u4ed6\u5730\u65b9\u3002\u4e00\u65e6\u88ab\u5524\u9192\uff0c\u8fd9\u4e9b\u7ec6\u80de\u4f1a\u589e\u6b96\u5e76\u751f\u957f\u6210\u8f6c\u79fb\u6027\u80bf\u7624\u3002\u51b7\u6cc9\u6e2f\u5b9e\u9a8c\u5ba4\u7684\u79d1\u5b66\u5bb6\u4eec\u8fd1\u65e5\u8bc6\u522b\u51fa\u4e00\u79cd\u4f34\u968f\u708e\u75c7\u7684\u3001\u53ef\u4ee5\u5524\u9192\u4f11\u7720\u764c\u7ec6\u80de\u7684\u4fe1\u53f7\u3002\u8fd9\u4e00\u65b0\u8ba4\u77e5\u6fc0\u53d1\u4e86\u4e00\u79cd\u65e8\u5728\u9884\u9632\u764c\u75c7\u590d\u53d1\u548c\u8f6c\u79fb\u7684\u65b0\u6cbb\u7597\u7406\u5ff5\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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9\u670828\u65e5\uff0c\u8fd9\u4e00\u6700\u65b0\u7814\u7a76\u4ee5\u201cHow dormant cancer persists and reawakens\u201d\u4e3a\u9898\u53d1\u8868\u5728\u300aScience\u300b\u6742\u5fd7\u3002<\/span><\/p>\n


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\"\u708e\u75c7\u8bf1\u5bfc\u764c\u75c7\u590d\u53d1\uff1fScience\u63ed\u793a\uff1a\u5524\u9192\u4f11\u7720\u764c\u7ec6\u80de\u7684\u4fe1\u53f7\"<\/p>\n

DOI\uff1a10.1126\/science.aav0191<\/span><\/p>\n


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\u708e\u75c7\u662f\u5426\u4f1a\u76f4\u63a5\u5bfc\u81f4\u764c\u75c7\u590d\u53d1\uff0c\u5982\u679c\u4f1a\uff0c\u5982\u4f55\u5bfc\u81f4\uff1f\u8fd9\u4e9b\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u3002\u5728\u51b7\u6cc9\u6e2f\u5b9e\u9a8c\u5ba4\uff08CSHL\uff09\u7684\u79d1\u5b66\u5bb6\u4eec\u7684\u65b0\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u8bc1\u660e\uff0c\u6301\u7eed\u7684\u80ba\u90e8\u708e\u75c7\uff0c\u5305\u62ec\u66b4\u9732\u5728\u70df\u8349\u70df\u96fe\u4e2d\u5f15\u8d77\u7684\u708e\u75c7\uff0c\u53ef\u4ee5\u5bfc\u81f4\u6f5c\u4f0f\u7684\u4e73\u817a\u764c\u548c\u524d\u5217\u817a\u764c\u7ec6\u80de\u82cf\u9192\u5e76\u5f00\u59cb\u5206\u88c2\u3002\u8fd9\u4e9b\u7ec6\u80de\u7ee7\u800c\u5728\u80ba\u90e8\u5f62\u6210\u8f6c\u79fb\u3002\u800c\u8f6c\u79fb\u764c\u6b63\u662f\u5927\u591a\u6570\u5e38\u89c1\u764c\u75c7\u81f4\u6b7b\u7684\u4e3b\u8981\u539f\u56e0\u3002<\/span><\/p>\n


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\u597d\u6d88\u606f\u662f\uff0c\u7531CSHL\u526f\u6559\u6388Mikala Egeblad\u9886\u5bfc\u7684\u56e2\u961f\uff0c\u5305\u62ecDana Farber\u764c\u75c7\u7814\u7a76\u6240\u548cUC Davis\u7684\u7814\u7a76\u4eba\u5458\uff0c\u5c55\u793a\u4e86\u4e00\u79cd\u963b\u65ad\u5524\u9192\u4f11\u7720\u764c\u7ec6\u80de\u7684\u4fe1\u53f7\u7684\u65b9\u6cd5\uff0c\u8fd9\u79cd\u6982\u5ff5\u53ef\u4ee5\u9632\u6b62\u764c\u75c7\u590d\u53d1\u6216\u964d\u4f4e\u590d\u53d1\u9891\u7387\u3002<\/strong><\/span><\/p>\n


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Egeblad\u7684\u7814\u7a76\u5c0f\u7ec4\u663e\u793a\uff0c\u6301\u7eed\u7684\u80ba\u90e8\u708e\u75c7\uff0c\u65e0\u8bba\u662f\u7531\u4e8e\u5c0f\u9f20\u66b4\u9732\u5728\u70df\u8349\u70df\u96fe\u4e2d\u8fd8\u662f\u7ec6\u83cc\u5185\u6bd2\u7d20\u4e2d\uff0c\u90fd\u4f1a\u4ee5\u4e00\u79cd\u975e\u540c\u5bfb\u5e38\u7684\u65b9\u5f0f\u8bf1\u5bfc\u666e\u901a\u767d\u7ec6\u80de\uff08\u5373\u4e2d\u6027\u7c92\u7ec6\u80de\uff09\u5524\u9192\u9644\u8fd1\u4f11\u7720\u7684\u764c\u7ec6\u80de\u3002<\/span><\/p>\n


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\"\u708e\u75c7\u8bf1\u5bfc\u764c\u75c7\u590d\u53d1\uff1fScience\u63ed\u793a\uff1a\u5524\u9192\u4f11\u7720\u764c\u7ec6\u80de\u7684\u4fe1\u53f7\"<\/p>\n

\u5f53\u80ba\u7ec4\u7ec7\u957f\u671f\u53d1\u708e\u65f6\uff0c\u4f11\u7720\u7684\u764c\u7ec6\u80de\u80fd\u591f\u52ab\u6301\u4ece\u9644\u8fd1\u7684\u767d\u7ec6\u80de\u4e2d\u55b7\u51fa\u7684\u7a00\u8584\u7684\u201c\u7f51\u201d\uff0c\u91cd\u65b0\u8fdb\u5165\u7ec6\u80de\u5468\u671f\u5e76\u91cd\u65b0\u5f00\u59cb\u751f\u957f\uff08\u6765\u6e90\uff1aEgeblad lab\uff09<\/span><\/p>\n


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\u55dc\u4e2d\u6027\u7c92\u7ec6\u80de\uff0c\u6211\u4eec\u901a\u5e38\u4f9d\u9760\u5b83\u6765\u6740\u6b7b\u5165\u4fb5\u8005\uff0c\u5982\u7ec6\u83cc\u548c\u9175\u6bcd\u3002\u5176\u4e2d\u4e00\u79cd\u6740\u6b7b\u5165\u4fb5\u8005\u7684\u65b9\u6cd5\u662f\u5c06\u5b83\u4eec\u7684DNA\u6392\u51fa\u7ec6\u80de\u819c\u4e4b\u5916\uff0c\u88ab\u6392\u51fa\u7684DNA\u5f62\u6210\u4e86\u4e00\u4e2a\u8584\u7eb1\u72b6\u7684\u7f51\u72b6\u9677\u9631(NETs)\uff0c\u53ef\u4ee5\u6740\u6b7b\u75c5\u539f\u4f53\u3002<\/span><\/p>\n


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\u65b0\u7684\u7814\u7a76\u8868\u660e\uff0c\u6301\u7eed\u7684\u80ba\u90e8\u708e\u75c7\u5bfc\u81f4\u4f11\u7720\u764c\u7ec6\u80de\u5468\u56f4\u533a\u57df\u5f62\u6210\u7f51\u72b6\u7ed3\u6784\u3002\u8be5\u7ed3\u6784\u4e2d\u4e24\u79cd\u79f0\u4e3aNE <\/strong>(\u4e2d\u6027\u7c92\u7ec6\u80de\u5f39\u6027\u86cb\u767d\u9176)\u548cMMP 9 <\/strong>(\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u91769 )\uff0c\u4e0e\u7ec4\u7ec7\u4e2d\u7684\u4e00\u79cd\u53eb\u505a\u5c42\u7c98\u8fde\u86cb\u767d\uff08laminin\uff09\u76f8\u4e92\u4f5c\u7528\u3002<\/strong>NE\u548cMMP9\u4f9d\u6b21\u5148\u540e\u5207\u5272\u5c42\u7c98\u8fde\u86cb\u767d\u3002\u8fd9\u6539\u53d8\u4e86\u86cb\u767d\u8d28\u7684\u5f62\u72b6\uff0c\u66b4\u9732\u51fa\u4e00\u4e2a\u53eb\u505a\u8868\u4f4d\uff08epitope\uff09\u7684\u65b0\u8868\u9762\uff08exposing a new surface\uff09\u3002<\/span><\/p>\n


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\"\u708e\u75c7\u8bf1\u5bfc\u764c\u75c7\u590d\u53d1\uff1fScience\u63ed\u793a\uff1a\u5524\u9192\u4f11\u7720\u764c\u7ec6\u80de\u7684\u4fe1\u53f7\"<\/p>\n

NE (\u7eff\u70b9)\u548cMMP9 (\u7ea2\u70b9)\u9176\u6563\u5e03\u5728\u4e2d\u6027\u7c92\u7ec6\u80de\u6216\u767d\u7ec6\u80de\u6392\u51fa\u7684DNA\u7f51\u652f\u67b6\u3002\u8fd9\u4e9b\u9176\u4f9d\u6b21\u5728\u80ba\u7ec4\u7ec7\u4e2d\u5206\u89e3\u4e00\u79cd\u53eb\u505a\u5c42\u86cb\u767d-111\u7684\u86cb\u767d\u8d28\uff0c\u8bf1\u5bfc\u4e00\u4e2a\u4fe1\u53f7\uff0c\u4f7f\u9644\u8fd1\u4f11\u7720\u7684\u764c\u7ec6\u80de\u91cd\u65b0\u82cf\u9192\u5e76\u5f00\u59cb\u589e\u6b96\uff08\u6765\u6e90\uff1aEgeblad lab\uff09<\/span><\/p>\n


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\u63a5\u4e0b\u6765\uff0c\u8be5\u5c0f\u7ec4\u521b\u9020\u4e86\u4e00\u79cd\u6297\u4f53\u6765\u963b\u65ad\u5c42\u7c98\u8fde\u86cb\u767d\u4e0a\u66b4\u9732\u7684\u8868\u4f4d\u3002\u5728\u5c0f\u9f20\u8eab\u4e0a\uff0c\u8fd9\u9632\u6b62\u4e86\u9644\u8fd1\u4f11\u7720\u764c\u7ec6\u80de\u7684\u518d\u6b21\u82cf\u9192\u3002<\/span><\/p>\n


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\"\u708e\u75c7\u8bf1\u5bfc\u764c\u75c7\u590d\u53d1\uff1fScience\u63ed\u793a\uff1a\u5524\u9192\u4f11\u7720\u764c\u7ec6\u80de\u7684\u4fe1\u53f7\"<\/p>\n

\u6700\u5de6\u8fb9\u6b63\u5e38\u5c0f\u9f20\u80ba\u7ec4\u7ec7\u4e2d\u53ef\u89c1\u5c11\u91cf\u5206\u6563\u7684\u767d\u7ec6\u80de\uff08\u5373\u4e2d\u6027\u7c92\u7ec6\u80de\uff0c\u7ea2\u8272)\u3002\u7ecf\u9f3b\u7ed9\u836f\u4fc3\u8fdb\u80ba\u90e8\u708e\u75c74\u5c0f\u65f6\u540e\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u6570\u91cf\u660e\u663e\u589e\u52a0\uff0c DNA NETs (\u7eff\u8272)\u9996\u6b21\u53ef\u89c1\u3002\u5728\u63a5\u4e0b\u6765\u7684\u51e0\u5929\u91cc\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u548cNETs\u968f\u7740\u708e\u75c7\u56e0\u5b50\u7684\u518d\u6b21\u91ca\u653e\u800c\u5360\u636e\u4e3b\u5bfc\u5730\u4f4d\u3002\u708e\u75c7\u548cNETs\u5f62\u6210\u7684\u76f4\u63a5\u5173\u7cfb\u6216\u5bfc\u81f4\u4f11\u7720\u764c\u7ec6\u80de\u91cd\u65b0\u82cf\u9192\u3002\uff08\u6765\u6e90\uff1aEgeblad lab\uff09<\/span><\/p>\n


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\u76ee\u524d\uff0c\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u5f00\u59cb\u4f18\u5316\u6297\u4f53\uff0c\u5e76\u5c06\u5176\u4e0e\u5176\u4ed6NETs\u65b9\u6cd5\u8fdb\u884c\u6bd4\u8f83\uff0c\u5e0c\u671b\u6700\u7ec8\u80fd\u5728\u4eba\u4f53\u4e2d\u8fdb\u884c\u8bd5\u9a8c\u3002<\/span><\/p>\n


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\u8d23\u7f16\uff1a\u6d6e\u82cf<\/span><\/strong><\/p>\n

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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/strong>1\uff09How a sleeping cancer awakens and metastasizes<\/span><\/span><\/p>\n

2\uff09How dormant cancer persists and reawakens<\/span><\/p>\n


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\u672c\u6587\u7cfb\u751f\u7269\u63a2\u7d22\u539f\u521b\uff0c\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u5206\u4eab\u3002\u5176\u4ed6\u4efb\u4f55\u5a92\u4f53\u3001\u7f51\u7ad9\u5982\u9700\u8f6c\u8f7d\uff0c\u987b\u5728\u6b63\u6587\u524d\u6ce8\u660e\u6765\u6e90\u751f\u7269\u63a2\u7d22\u3002<\/span><\/p>\n<\/section>\n

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\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u6297\u764c\u5e38\u88ab\u6bd4\u4f5c\u6253\u5730\u9f20\u6e38\u620f\uff0c\u56e0\u4e3a\u5373\u4f7f\u764c\u75c7\u6cbb\u7597\u6210\u529f\uff0c\u539f\u53d1\u80bf\u7624\u4e2d\u4f11\u7720\u548c\u672a\u5206\u88c2\u7684\u764c\u7ec6\u80de\u4ecd\u53ef\u80fd\u5b58\u5728\u4e8e\u8eab\u4f53\u5176\u4ed6\u5730\u65b9\u3002\u4e00\u65e6\u88ab\u5524 […]<\/p>\n","protected":false},"author":1,"featured_media":55749,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/55748"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=55748"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/55748\/revisions"}],"predecessor-version":[{"id":55754,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/55748\/revisions\/55754"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/55749"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=55748"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=55748"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=55748"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}