{"id":56185,"date":"2018-09-26T01:00:00","date_gmt":"2018-09-30T02:12:46","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e6%b7%b1%e5%ba%a6%ef%bc%9a%e6%96%b0%e8%8d%af%e7%a0%94%e5%8f%91%e6%88%90%e6%9c%ac%e5%a4%a7%e6%8f%ad%e7%a7%98\/"},"modified":"2018-09-30T10:12:51","modified_gmt":"2018-09-30T02:12:51","slug":"%e6%b7%b1%e5%ba%a6%ef%bc%9a%e6%96%b0%e8%8d%af%e7%a0%94%e5%8f%91%e6%88%90%e6%9c%ac%e5%a4%a7%e6%8f%ad%e7%a7%98","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/56185\/","title":{"rendered":"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8"},"content":{"rendered":"
\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"<\/p>\n

\n
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\n
\n
\n
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\u5bfc\u8bfb<\/strong><\/section>\n

\u3000<\/span><\/section>\n

\n

\u65b0\u836f\u7814\u53d1\u4e00\u76f4\u88ab\u8ba4\u4e3a\u662f\u9ad8\u98ce\u9669\u3001\u9ad8\u6536\u76ca\u7684\u6d3b\u52a8\uff0c\u8fc7\u53bb\u4e1a\u754c\u4e00\u76f4\u6d41\u4f20\u7740\u201c\u53cc\u5341\u201d\u7684\u8bf4\u6cd5\uff0c\u610f\u601d\u662f\uff1a\u65b0\u836f\u7814\u53d1\u9700\u8981\u8017\u65f6\u5341\u5e74\uff0c\u8017\u8d44\u5341\u4ebf\u7f8e\u91d1\u3002\u5982\u4eca\uff0c\u5404\u5927\u8de8\u8fc7\u836f\u4f01\u89c9\u5f97\u5f88\u201c\u51a4\u6789\u201d\uff0c\u8ba4\u4e3a\u5982\u4eca\u7684\u4e00\u4e2a\u65b0\u836f\u7814\u53d1\u7684\u6210\u672c\u53ef\u8fdc\u4e0d\u6b62\u8fd9\u6570\u5b57\uff0c\u6309\u71672014\u5e74Tufts Center\u7684\u7edf\u8ba1\u62a5\u544a\uff0c\u76ee\u524d\u7814\u53d1\u4e2a\u65b0\u836f\u7684\u6210\u672c\u5df2\u7ecf\u9ad8\u8fbe25.88\u4ebf\u7f8e\u91d1\uff01\u4f46\u66f4\u591a\u5176\u4ed6\u7684\u6570\u636e\u7edf\u8ba1\u51fa\u6765\u7684\u7ed3\u679c\u5374\u5927\u76f8\u5f84\u5ead\uff0c\u771f\u5b9e\u60c5\u51b5\u7a76\u7adf\u5982\u4f55\uff0c\u8ba9\u6211\u4eec\u4e00\u8d77\u63a2\u4e2a\u7a76\u7adf!<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"
<\/p>\n

\u4e00\u3001\u65b0\u836f\u5f00\u53d1\u6210\u672c\u6570\u636e\u5206\u6790<\/strong><\/span><\/p>\n


<\/p>\n

Tufts Center\u7edf\u8ba1\u7ed3\u679c\u5206\u6790<\/strong><\/span><\/p>\n

Tufts Center\u7edf\u8ba1\u6570\u636e\u6765\u6e90\u4e8e1995\u5e74\u81f32007\u5e74\uff0c\u6765\u81ea10\u5bb6\u516c\u53f8\u7684106\u79cd\uff081,442\u4e2a\u5316\u5408\u7269\uff09\u7814\u7a76\u6027\u65b0\u836f\u548c\u751f\u7269\u5236\u5242\u7814\u53d1\u8d39\u7528\u7684\u5206\u6790\u3002\u7edf\u8ba1\u7684\u7814\u53d1\u8d39\u7528\u5305\u62ec\u836f\u7269\u6240\u6709\u5f00\u53d1\u9002\u5e94\u75c7\u7684\u957f\u671f\u52a8\u7269\u8bd5\u9a8c\uff0c\u516c\u53f8\u7ba1\u7406\u8d39\u7528\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u671f\u95f4\u548c\u9996\u6b21\u6279\u51c6\u524d\u7684CMC\u8d39\u7528\u3002<\/span><\/p>\n

\u7edf\u8ba1\u7684\u7ed3\u679c\u5982\u4e0b\uff1a<\/span><\/p>\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"<\/p>\n

<\/span>\u6570\u636e\u6765\u6e90\uff1aCost of Developing a New Drug<\/span><\/span><\/p>\n

\u4ece\u56fe\u4e2d\u7b14\u8005\u5f97\u51fa\u4ee5\u4e0b\u51e0\u4e2a\u7ed3\u8bba\uff1a<\/span><\/p>\n

\u00b7 \u6210\u529f\u5f00\u53d1\u4e00\u4e2a\u836f\u7269\uff0c\u836f\u4f01\u5b9e\u9645\u7684\u638f\u51fa\u7684\u82b1\u8d39\u4e3a13.95\u4ebf\u7f8e\u91d1\uff0c\u6309\u7167\u540d\u4e49\u5229\u7387\uff08\u8d44\u672c\u6210\u672c\uff09\u4e3a12-14%\u6765\u7b97\uff0c\u5f25\u8865\u8d44\u672c\u65f6\u95f4\u548c\u673a\u4f1a\u6210\u672c\u5f97\u51fa\u5f00\u53d1\u4e00\u4e2a\u65b0\u836f\u7684\u6210\u672c\u4e3a25.58\u4ebf\u7f8e\u91d1\u3002<\/span><\/p>\n

\u00b7 \u867d\u7136\u4e34\u5e8a\u82b1\u8d39\u8f83\u591a\uff0c\u5c24\u5176\u662fIII\u671f\u7684\u4e34\u5e8a\u5f00\u53d1\u6210\u672c\u5de8\u5927\uff0c\u76f8\u53cd\u4e34\u5e8a\u524d\u5f00\u53d1\u6210\u672c\u8f83\u5c0f\uff0c\u4f46\u8003\u8651\u5230\u8d44\u91d1\u7684\u65f6\u95f4\u6210\u672c\u540e\uff0c\u5b9e\u9645\u4e0a\u4e34\u5e8a\u524d\u7684\u5f00\u53d1\u8d39\u7528\u548c\u4e34\u5e8a\u5f00\u53d1\u8d39\u7528\u8d44\u672c\u5316\u540e\uff0c\u76f8\u5dee\u5e76\u4e0d\u5927\u3002<\/span><\/p>\n

\u00b7 Tufts Center\u7edf\u8ba1\u7684\u662f\u8fd910\u5bb6\u516c\u53f81442\u4e2a\u5316\u5408\u7269\u7684\u5f00\u53d1\u8d39\u7528\uff0c\u5305\u542b\u4e86\u5931\u8d25\u7684\u5316\u5408\u7269\u5f00\u53d1\u7684\u8d44\u91d1\u673a\u4f1a\u6210\u672c\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u5f00\u53d1\u4e8610\u4e2a\u5316\u5408\u7269\uff0c\u6700\u7ec8\u80fd\u62101\u4e2a\uff0c\u5176\u4f59\u7684\u5f00\u53d1\u90a39\u4e2a\u836f\u7269\u7684\u6210\u672c\u4e5f\u5f97\u7b97\u5728\u6210\u529f\u7684\u90a3\u4e2a\u5934\u4e0a\u3002<\/span><\/p>\n

\u00b7 \u8ba1\u7b97\u65b0\u836f\u8d44\u672c\u5316\u540e\u7814\u53d1\u6210\u672c\u6709\u4e24\u4e2a\u5f88\u91cd\u8981\u7684\u53d8\u91cf\uff1a\u7814\u53d1\u6210\u529f\u7387\u548c\u7814\u53d1\u65f6\u95f4\u3002<\/span><\/p>\n

Tufts Center\u7edf\u8ba1\u7684\u7ed3\u679c\u53ea\u662f\u7b80\u5355\u7684\u9648\u8ff0\u4e00\u4e0b\u7ed3\u679c\uff0c\u5177\u4f53\u7684\u7ec6\u5316\u7684\u63a8\u5bfc\u8fc7\u7a0b\u76ee\u524d\u7b14\u8005\u8fd8\u5e76\u672a\u627e\u5230\u3002\u8fd9\u6837\u7a7a\u6cdb\u7684\u7ed3\u8bba\u5f88\u96be\u8ba9\u4eba\u7406\u89e3\uff0c\u5e78\u597d\u7b14\u8005\u5728\u53e6\u5916\u4e00\u7bc7\u6587\u732e\u4e2d\u627e\u5230\u4e86\u7b54\u6848\uff0c\u5982\u4e0b\u56fe\uff1a<\/span><\/p>\n

\u56fe\uff1aR&D model yielding costs to successfully discover and develop a single new molecular entity.<\/span><\/span><\/p>\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"<\/p>\n

\u6570\u636e\u6765\u6e90\uff1aHow to improve R&D productivity: the pharmaceutical industry\u2019s grand challenge
<\/span><\/p>\n

\u5907\u6ce8\uff1ap(TS)\uff1a\u5230\u4e00\u4e0b\u9636\u6bb5\u6210\u529f\u7684\u6982\u7387\uff1b<\/span><\/p>\n

WIP needed for 1 lanuch:\u672c\u9636\u6bb5\u5230\u6700\u7ec8\u80fd\u4e0a\u5e02\u6240\u9700\u7814\u7a76\u7684\u5316\u5408\u7269\u6570\u91cf\uff1b<\/span><\/p>\n

cost per WIP per phase:\u672c\u9636\u6bb5\u6bcf\u4e2a\u5316\u5408\u7269\u6240\u9700\u7684\u7814\u53d1\u8d39\u7528\uff1b<\/span><\/p>\n

cycle time:\u672c\u9636\u6bb5\u5230\u4e0b\u9636\u6bb5\u7814\u53d1\u5468\u671f\uff1b<\/span><\/p>\n

cost per launch (out of pocket)\uff1a\u672c\u9636\u6bb5\u9700\u8981\u836f\u4f01\u7684\u5b9e\u9645\u7814\u53d1\u82b1\u8d39\uff08\u767e\u4e07\u7f8e\u5143\uff09\uff1b<\/span><\/p>\n

% Total cost per NME:\u672c\u9636\u6bb5\u7814\u53d1\u652f\u51fa\u5360\u603b\u7814\u53d1\u8d39\u7528\u7684\u6bd4\u4f8b\uff1b<\/span><\/p>\n

cost of capital: \u8d44\u672c\u6210\u672c\uff1b<\/span><\/p>\n

Cost per launch(capitalzed)\uff1a\u672c\u9636\u6bb5\u8d44\u672c\u5316\u540e\u7684\u7814\u53d1\u8d39\u7528\uff08\u767e\u4e07\u7f8e\u5143\uff09\u3002<\/span><\/p>\n

\u4ece\u4e0a\u56fe\uff0c\u7b14\u8005\u53ef\u4ee5\u5f97\u51fa\u4ee5\u4e0b\u7ed3\u8bba\uff1a<\/span><\/p>\n

\u00b7 \u4e0a\u56fe\u7edf\u8ba1\u5f97\u51fa\u7684\u836f\u4f01\u7814\u53d1\u51fa\u4e2a\u65b0\u836f\u5b9e\u9645\u82b1\u8d39\u4e3a8.73\u4ebf\u7f8e\u91d1\u3001\u8d44\u672c\u5316\u540e\u7684\u7814\u53d1\u8d39\u752817.78\u4ebf\u7f8e\u5143\uff0c\u4e0e Tufts Center\u7edf\u8ba1\u51fa\u7684\u7ed3\u679c\u76f8\u5dee\u5e76\u4e0d\u5927\uff0c\u5dee\u5f02\u53ef\u80fd\u6765\u6e90\u4e8e\u6837\u672c\u7684\u9009\u62e9\u3002\u5907\u6ce8\uff1a\u4e0d\u540c\u9776\u70b9\u3001\u4e0d\u540c\u9002\u5e94\u75c7\u3001\u4e0d\u540c\u836f\u4f01\u7684\u5f00\u53d1\u6210\u672c\u5b58\u5728\u8f83\u5927\u5dee\u5f02\u3002<\/span><\/p>\n

\u00b7 \u4e34\u5e8a\u524d\u8fc7\u7a0b\u4e2d\uff0c\u5316\u5408\u7269\u7ed3\u6784\u4f18\u5316\u9636\u6bb5\u82b1\u8d39\u5de8\u5927\uff0c\u7ea6\u4e3a1.46\u4ebf\u7f8e\u91d1\uff08\u517114.6\u4e2a\u5316\u5408\u7269\uff09\uff0c\u4e34\u5e8a\u5f00\u53d1\u8fc7\u7a0b\u4e2dIII\u671f\u4e34\u5e8a\u5f00\u53d1\u82b1\u8d39\u5de8\u5927\uff0c\u5e73\u5747\u6bcf\u4e2a\u836f\u7269\u82b1\u8d391.5\u4ebf\u7f8e\u91d1\u3002<\/span><\/p>\n

\u00b7 \u836f\u7269\u5f00\u53d1\u5468\u671f\u4ece\u4e34\u5e8a\u524d\u9776\u70b9\u7b5b\u9009\u5230\u6700\u7ec8\u4e0a\u5e02\uff0c\u5e73\u5747\u81f3\u5c1113.5\u5e74\uff08\u4e0d\u5305\u62ec\u9776\u70b9\u786e\u8ba4\u9636\u6bb5\uff09\uff0c\u4e34\u5e8a\u524d\u5f00\u53d1\u6240\u9700\u65f6\u95f4\u4e3a5.5\u5e74\uff0c\u4e34\u5e8a\u5e73\u5747\u5f00\u53d1\u65f6\u95f4\u4e3a8\u5e74\u3002<\/span><\/p>\n

\u00b7 \u8d44\u672c\u5316\u540e\u7684\u7814\u53d1\u8d39\u7528\u4e2d\uff0c\u4e34\u5e8a\u524d\u7ed3\u6784\u4f18\u5316\u9636\u6bb5\uff0814.6\u4e2a\u836f\u7269\uff09\u82b1\u8d394.14\u4ebf\u7f8e\u91d1\u5176\u5b9e\u6bd4III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff081.6\u4e2a\u836f\u7269\uff093.14\u4ebf\u7f8e\u91d1\uff0c\u82b1\u8d39\u8fd8\u5de8\u5927\u3002\uff08\u8fd9\u7ed3\u679c\u51fa\u4e4e\u7b14\u8005\u610f\u6599\uff09<\/span><\/p>\n

\u4ee5\u4e0a\u7684\u7edf\u8ba1\u6570\u636e\u5747\u662f\u836f\u7269\u5f00\u53d1\u6210\u672c\u5747\u503c\uff0c\u8fd9\u8ba9\u7b14\u8005\u5f88\u96be\u7406\u89e3\uff0c\u4e5f\u5f88\u96be\u4fe1\u670d\u3002\u4e8e\u662f\u7b14\u8005\u7279\u5730\u627e\u4e86\u4e9b\u5177\u4f53\u7684\u5f00\u53d1\u6210\u672c\u5b9e\u4f8b\uff0c\u4f9b\u8bfb\u8005\u5206\u4eab\u3002<\/span><\/p>\n


<\/p>\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"
<\/p>\n

\u4e8c\u3001\u80bf\u7624\u836f\u7269\u5f00\u53d1\u6210\u672c\u7684\u5177\u4f53\u5b9e\u4f8b<\/span><\/p>\n

Vinay Prasad\u7b49\u4eba\u7edf\u8ba1\u4e862006\u5e741\u67081\u65e5\u548c2015\u5e7412\u670831\u65e5\u671f\u95f4\u768410\u79cdFDA\u6279\u51c6\u4e0a\u5e02\u7684\u6297\u80bf\u7624\u836f\u7269\u5f00\u53d1\u6210\u672c\uff0c\u7ed3\u679c\u4e0b\u8868\u6240\u793a\uff1a<\/span><\/p>\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"<\/p>\n

\u6570\u636e\u6765\u6e90\uff1aJAMA internal medicine, 2017, 177(11): 1569-1575<\/span><\/span><\/p>\n

\u4ece\u56fe\u4e2d\u7b14\u8005\u53ef\u4ee5\u5f97\u51fa\u4ee5\u4e0b\u7ed3\u8bba\uff1a<\/span><\/p>\n

\u00b7 \u8fd910\u4e2aFDA\u6279\u51c6\u4e0a\u5e02\u7684\u6297\u80bf\u7624\u836f\u7269\u5e73\u5747\u7814\u53d1\u6210\u672c\u4e3a7.2\u4ebf\u7f8e\u91d1\uff0c\u548c\u4e0a\u9762\u7edf\u8ba1\u7684\u5e73\u5747\u836f\u7269\u5f00\u53d1\u6210\u672c\u6bd4\u8f83\u543b\u5408\u3002<\/span><\/p>\n

\u00b7 \u5355\u4e2a\u65b0\u836f\u7684\u7814\u53d1\u6210\u672c\u76f8\u5dee\u5de8\u5927\uff0cpralatrexate\uff08\u666e\u62c9\u66f2\u6c99\uff09\u7814\u53d1\u6210\u672c\u53ea\u97001.78\u4ebf\u7f8e\u91d1\uff0c\u800ccabozantinib\uff08\u5361\u535a\u66ff\u5c3c\u80f6\u56ca\uff09\u5f00\u53d1\u7adf\u7136\u9ad8\u8fbe19.5\u4ebf\u7f8e\u91d1\u3002\u56e0\u6b64\u4e0d\u540c\u836f\u7269\u4e4b\u95f4\u7684\u5f00\u53d1\u6210\u672c\u76f8\u4e92\u53c2\u8003\u7684\u4ef7\u503c\u4e0d\u5927\u3002<\/span><\/p>\n

\u7b14\u8005\u5728\u82e5\u5e72\u5e74\u524d\u8bfb\u4e66\u65f6\u671f\uff0c\u8001\u5e08\u5c31\u6559\u5bfc\u6211\u4eec\u65b0\u836f\u4e0a\u5e02\u8981\u8017\u8d4410\u4ebf\u7f8e\u5143\u4e4b\u5de8\uff0c\u53ef\u5982\u4eca\u5374\u66b4\u6da8\u523026\u4ebf\u7f8e\u91d1\u3002\u8fd9\u4e0d\u8ba9\u7b14\u8005\u6709\u8fd9\u6837\u7684\u7591\u95ee\uff0c\u4e0d\u540c\u65f6\u671f\u4e0b\uff0c\u65b0\u836f\u7814\u53d1\u7684\u6210\u672c\u6709\u7740\u600e\u6837\u7684\u5dee\u5f02\uff1f<\/span><\/p>\n


<\/p>\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"
<\/p>\n

\u4e09\u3001\u4e0d\u540c\u65f6\u671f\u4e0b\u7684\u65b0\u836f\u7814\u53d1\u6210\u672c\u53d8\u5316<\/span><\/p>\n

Steve Morgan\u7b49\u4eba\u7efc\u8ff0\u4e86\u8fd1\u534a\u4e2a\u4e16\u7eaa\u4ee5\u6765\u6240\u62a5\u9053\u7684\u65b0\u836f\u5f00\u53d1\u6210\u672c\u53d8\u5316\uff0c\u5982\u4e0b\u6240\u793a\uff1a<\/span><\/p>\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"<\/p>\n

\u6570\u636e\u6765\u6e90\uff1aThe cost of drug development: A systematic review<\/span><\/span><\/p>\n

\u6070\u597dTufts Center\u4e2d\u5fc3\u4e5f\u7edf\u8ba1\u4e86\u76f8\u5173\u7684\u6570\u636e\uff1a<\/span><\/p>\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"<\/p>\n

\u6570\u636e\u6765\u6e90\uff1aCost of Developing a New Drug<\/span><\/span><\/p>\n

\u4ece\u56fe\u4e2d\u7b14\u8005\u5f97\u51fa\u5982\u4e0b\u7ed3\u8bba\uff1a<\/span><\/p>\n

\u00b7 \u4e0d\u540c\u65f6\u671f\uff0c\u5355\u4e2a\u65b0\u836f\u4e0a\u5e02\u7684\u5f00\u53d1\u6210\u672c\u76f8\u5dee\u5de8\u5927\uff0c1960s\u65f6\u671f\uff0c\u5e73\u5747\u836f\u7269\u7684\u5f00\u53d1\u6210\u672c\u53ea\u97000.92\u4ebf\u7f8e\u91d1\uff0c\u800c\u5230\u4e862000\u5e74\uff0c\u5e73\u5747\u836f\u7269\u7684\u5f00\u53d1\u6210\u672c\u5df2\u7ecf\u9ad8\u8fbe6-8\u4ebf\u7f8e\u91d1\u3002<\/span><\/p>\n

\u00b7 \u968f\u7740\u65f6\u95f4\u8fdb\u5c55\uff0c\u65b0\u836f\u5f00\u53d1\u7684\u6210\u672c\u9661\u7136\u4e0a\u5347\uff0c\u6210\u672c\u5728\u6bcf\u9694\u5341\u5e74\u4e2d\u7ffb\u500d\u3002<\/span><\/p>\n

\u00b7 \u6587\u4e2d\uff0c\u4f5c\u8005\u5e76\u6ca1\u6709\u89e3\u91ca\u8fd9\u4e2a\u73b0\u8c61\u80cc\u540e\u7684\u539f\u56e0\uff0c\u4e2a\u4eba\u8ba4\u4e3a\u548c\u65b0\u836f\u7814\u53d1\u7684\u6210\u529f\u7387\u4e0d\u65ad\u964d\u4f4e\u3001\u4e34\u5e8a\u8bd5\u9a8c\u6210\u672c\u4e0d\u65ad\u589e\u52a0\u3001\u76d1\u7ba1\u6761\u4ef6\u66f4\u52a0\u4e25\u683c\u7b49\u65b9\u9762\u6709\u6bd4\u8f83\u5927\u7684\u5173\u7cfb\u3002\u7531\u4e8e\u6bcf\u4e00\u79cd\u65b0\u836f\u90fd\u63d0\u9ad8\u4e86\u5f53\u524d\u7684\u6807\u51c6\uff0c\u8fd9\u53ea\u4f1a\u63d0\u9ad8\u4e0b\u4e00\u4e2a\u836f\u7269\u8fdb\u5165\u8fd9\u4e2a\u5e02\u573a\u7684\u6807\u51c6\uff0c\u4f7f\u7814\u53d1\u66f4\u52a0\u6602\u8d35\uff0c\u96be\u5ea6\u66f4\u5927\u3002\u5f53\u7136\u6700\u672c\u8d28\u7684\u539f\u56e0\u8fd8\u662f\u836f\u4f01\u6b63\u5728\u5feb\u901f\u5730\u6d88\u8017\u5df2\u7ecf\u6240\u5269\u65e0\u51e0\u7684\u53ef\u884c\u7684\u65b0\u836f\u9776\u70b9\uff01<\/span><\/p>\n


<\/p>\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"
<\/p>\n

\u56db\u3001\u4e0d\u540c\u4e34\u5e8a\u9636\u6bb5\u7684\u836f\u7269\u5f00\u53d1\u6210\u672c\u5206\u6790<\/span><\/p>\n

\u77e5\u540d\u533b\u836f\u54a8\u8be2\u516c\u53f8Igeahub\u6309\u7167\u4e0d\u540c\u6cbb\u7597\u9886\u57df\u548c\u4e0d\u540c\u4e34\u5e8a\u9636\u6bb5\u5bf9\u65b0\u836f\u4e34\u5e8a\u5f00\u53d1\u6210\u672c\u8fdb\u884c\u4e86\u7edf\u8ba1\uff0c\u7edf\u8ba1\u7ed3\u679c\u5982\u4e0b\u56fe\u6240\u793a\uff1a<\/span><\/p>\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"<\/p>\n

\u6570\u636e\u6765\u6e90\uff1aExamination of clinical trial costs and barriers for drug development<\/span><\/span><\/p>\n

\u4ece\u56fe\u4e2d\u7b14\u8005\u53ef\u4ee5\u5f97\u51fa\u5982\u4e0b\u7ed3\u8bba\uff1a<\/span><\/p>\n

\u00b7 \u4ee5\u4e0a\u7684\u6570\u636e\u662fIgeahub\u516c\u53f8\u6839\u636e\u81ea\u5df1\u7684\u8bbe\u5b9a\u7684\u6a21\u578b\u7b97\u51fa\u7684\u4e34\u5e8a\u7814\u7a76\u6210\u672c\uff0c\u4e3a\u5355\u4e2a\u836f\u7269\u5355\u4e2a\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u7814\u7a76\u6210\u672c\uff0c\u8fdc\u6bd4\u5236\u836f\u516c\u53f8\u5728\u5b9e\u9645\u7684\u65b0\u836f\u5f00\u53d1\u8d39\u7528\u8981\u5c0f\u3002<\/span><\/p>\n

\u00b7 \u5f00\u5c55\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6210\u672c\u5728\u4e0d\u540c\u6cbb\u7597\u9886\u57df\u3001\u4e0d\u540c\u4e34\u5e8a\u9636\u6bb5\u90fd\u5b58\u5728\u7740\u5f88\u5927\u4e0d\u540c\u3002I\u3001II\u3001III\u671f\u4e34\u5e8a\u7814\u7a76\u6210\u672c\u9010\u6e10\u589e\u9ad8\u3002\u5728\u75be\u75c5\u7684\u6cbb\u7597\u9886\u57df\u4e2d\uff0c\u547c\u5438\u7cfb\u7edf\u9886\u57df\u7684\u4e34\u5e8a\u8bd5\u9a8c\u662f\u6700\u6602\u8d35\u7684\uff0cI\u671f\u81f3IV\u671f\u7684\u603b\u6210\u672c\u57281.153\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

\u4e34\u5e8a\u8bd5\u9a8c\u8d39\u7528\u5305\u62ec\u54ea\u4e9b\uff1f<\/span><\/p>\n

\u4e0b\u8868\u63d0\u4f9b\u4e86\u5728\u7f8e\u56fd\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u9884\u8ba1\u7684\u6210\u672c\u6784\u6210\u5206\u89e3\u3002\u9664\u53bb\u73b0\u573a\u7ba1\u7406\u8d39\u7528\uff08740\u4e07\u7f8e\u5143\uff09\u548c\u5176\u4ed6\u672a\u5206\u7c7b\u7684\u8d39\u7528\uff081710\u4e07\u7f8e\u5143\uff09\u4e4b\u5916\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u6700\u6602\u8d35\u7684\u7ec4\u6210\u90e8\u5206\u5305\u62ec\uff1a\u884c\u653f\u4eba\u5458\u8d39\u7528\uff08720\u4e07\u7f8e\u5143\uff09\u3001\u4e34\u5e8a\u7a0b\u5e8f\u8d39\u7528\uff08590\u4e07\u7f8e\u5143\uff09\u3001\u73b0\u573a\u76d1\u6d4b\u8d39\u7528\uff08450\u4e07\u7f8e\u5143\uff09\u548c\u73b0\u573a\u4fdd\u7559\u8d39\u7528\uff08450\u4e07\u7f8e\u5143\uff09\u3002\u4ece\u6bcf\u4e00\u9636\u6bb5\u7684\u5c0f\u8ba1\u6210\u672c\u6765\u770b\uff0c\u968f\u7740\u4e34\u5e8a\u8bd5\u9a8c\u4eceI\u671f\u5411IV\u671f\u7684\u9010\u6e10\u63a8\u8fdb\uff0c\u6210\u672c\u7684\u589e\u52a0\u76f8\u5f53\u660e\u663e\u3002<\/span><\/p>\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"<\/p>\n

\u6570\u636e\u6765\u6e90\uff1aExamination of clinical trial costs and barriers for drug development<\/span><\/span><\/p>\n


<\/p>\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"
<\/p>\n

\u4e94\u3001\u56fd\u5185\u836f\u4f01\u65b0\u836f\u5f00\u53d1\u6210\u672c\u7684\u601d\u8003<\/span><\/p>\n

\u4e0a\u9762\u7b14\u8005\u8c08\u7684\u90fd\u662f\u56fd\u5916\u836f\u4f01\u5f00\u53d1\u65b0\u836f\u7684\u6210\u672c\uff0c\u8fd9\u5176\u5b9e\u8ddf\u56fd\u5185\u7684\u5b9e\u9645\u60c5\u51b5\u5dee\u8ddd\u5f88\u5927\u3002\u56fd\u5185\u836f\u4f01\u6210\u529f\u5f00\u53d1\u7684\u65b0\u836f\u6570\u91cf\u8f83\u5c11\uff0c\u62ab\u9732\u51fa\u6765\u7684\u5f00\u53d1\u6210\u672c\u4fe1\u606f\u66f4\u5c11\u3002\u6709\u51e0\u4e2a\u6570\u636e\u53ef\u4ee5\u8ddf\u8bfb\u8005\u5206\u4eab\u4e00\u4e0b\uff0c\u6d77\u6b63\u7684\u6d77\u6cfd\u9ea6\u5e03\u7247\u82b1\u8d392.25\u4ebf\u5143\uff0c\u6052\u745e\u7684\u5421\u54af\u66ff\u5c3c5.2\u4ebf\u5143\uff0cPD-1\uff08\u62a5\u4ea7\uff091.55\u4ebf\u5143\uff0c\u963f\u5229\u6c99\u5766\u916f\u4e0d\u52303\u4ebf\u5143\uff0c\u57c3\u514b\u66ff\u5c3c\u7684\u7d2f\u8ba1\u7814\u53d1\u8d39\u7528\u57281.5\u4ebf\u5143\u5de6\u53f3\u3002\u4ece\u4e2d\u6211\u4eec\u53ef\u4ee5\u7aa5\u63a2\u51fa\uff0c\u4f30\u8ba1\u56fd\u5185\u836f\u4f01\u5927\u6982\u5f00\u53d1\u4e00\u4e2a\u65b0\u836f\u7684\u6210\u672c\u57282-3\u4ebf\u5143\u5de6\u53f3\u3002\u8fd9\u4e2a\u8d39\u7528\u53ea\u662f\u8be5\u9879\u76ee\u7684\u7d2f\u8ba1\u6295\u5165\u8d39\u7528\uff0c\u4e0d\u5305\u542b\u5176\u4ed6\u9879\u76ee\u7814\u53d1\u5931\u8d25\u7684\u6295\u5165\uff0c\u4ee5\u53ca\u8d44\u91d1\u7684\u673a\u4f1a\u6210\u672c\u3002<\/span><\/p>\n

\u90a3\u662f\u4e0d\u662f\u8bf4\uff0c\u56fd\u5185\u7684\u836f\u4f01\u7814\u53d1\u6548\u7387\u8981\u8fdc\u8fdc\u9ad8\u4e8e\u56fd\u5916\u5462\uff1f\u7b14\u8005\u89c9\u5f97\u5c1a\u4e0d\u80fd\u5f97\u51fa\u5982\u6b64\u7684\u7ed3\u8bba\uff0c\u56e0\u4e3a\u56fd\u5185\u7684\u65b0\u836f\u7814\u53d1\u73b0\u72b6\u548c\u56fd\u5916\u6709\u5de8\u5927\u5dee\u5f02\u3002\u7b14\u8005\u5bf9\u6b64\u6709\u5982\u4e0b\u7684\u601d\u8003\uff1a<\/span><\/p>\n

1\u3001\u56fd\u5185\u76ee\u524d\u836f\u4f01\u505a\u7684\u5927\u591a\u662fme-too\u7c7b\u836f\u7269\uff0c\u5b58\u5728\u8f83\u4f4e\u7684\u5931\u8d25\u98ce\u9669\uff0c\u800c\u4e14\u4e0d\u9700\u8981\u524d\u671f\u7684\u9776\u70b9\u9a8c\u8bc1\u5de5\u4f5c\u3002\u52a0\u4e0a\u56fd\u5185\u4e34\u5e8a\u8bd5\u9a8c\u8d44\u6e90\u6210\u672c\u504f\u4f4e\uff0c\u7814\u53d1\u4eba\u5458\u5de5\u8d44\u504f\u4f4e\uff0c\u5bfc\u81f4\u56fd\u5185\u7684\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u5e45\u5ea6\u4f4e\u4e8e\u56fd\u5916\uff0c\u548c\u56fd\u5916\u52a8\u8f84\u657010\u4ebf\u7f8e\u91d1\u76f8\u6bd4\uff0c\u76f8\u5f62\u89c1\u7ecc\u3002<\/span><\/p>\n

2\u3001\u5e26\u6765\u7684\u95ee\u9898\u4e3b\u8981\u6709\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\uff1a<\/span><\/p>\n

\u00b7 \u56fd\u5185\u836f\u4f01\u65b0\u836f\u7814\u53d1\u540c\u8d28\u5316\u975e\u5e38\u4e25\u91cd\uff0c\u540c\u4e00\u4e2a\u9776\u70b9\u591a\u8fbe\u5341\u51e0\u5bb6\u5728\u7814\uff0c\u54ea\u6015\u662f\u7b2c\u4e00\u68af\u961f\u5df2\u7ecf\u6709\u4e09\u56db\u5bb6\u7ade\u4e89\u8005\uff0c\u540e\u7eed\u4ecd\u7136\u6709\u7b2c\u4e8c\u68af\u961f\u548c\u7b2c\u4e09\u68af\u961f\u7684\u524d\u4ec6\u540e\u7ee7\u3002\u56e0\u6b64\u53c2\u8003\u56fd\u5916\u7684\u65b0\u836f\u4ea7\u54c1\u751f\u547d\u5468\u671f\uff0c\u540e\u7eed\u7684\u7ade\u4e89\u8005\u662f\u5426\u5206\u5230\u4e00\u676f\u7fb9\uff0c\u8fd8\u6709\u5f85\u9a8c\u8bc1\u3002<\/span><\/p>\n

\u00b7 \u56fd\u5185\u867d\u7136\u65b0\u836f\u7814\u53d1\u7684\u6210\u672c\u5f88\u4f4e\uff0c\u4f46\u56fd\u5185\u7684\u60a3\u8005\u652f\u4ed8\u80fd\u529b\u66f4\u4f4e\uff0c\u836f\u54c1\u7684\u552e\u4ef7\u4ee5\u53ca\u65b0\u836f\u7684\u6e17\u900f\u7387\uff0c\u8fdc\u8fdc\u4f4e\u4e8e\u56fd\u5916\u3002\u56e0\u6b64\u56fd\u5185\u65b0\u836f\u7684\u9500\u552e\u5cf0\u503c\u4ee5\u53ca\u653e\u91cf\u901f\u5ea6\u4e5f\u8fdc\u4e0d\u5982\u56fd\u5916\u3002<\/span><\/p>\n

3\u3001\u56fd\u5916Kelvin Stott\u7b49\u4eba\u4ee5\u53ca\u5fb7\u52e4\u7edf\u8ba1\u4e86\u836f\u4f01\u7814\u53d1\u65b9\u9762\u7684\u5185\u90e8\u6536\u76ca\u7387\uff08IRR\uff09\u968f\u7740\u65f6\u95f4\u7684\u53d8\u5316\uff0c\u7ed3\u679c\u5982\u4e0b\u56fe\u6240\u793a\u3002\u52302017\u5e74\u65f6\u671f\uff0cIRR\u7adf\u7136\u4f4e\u81f33.2%\u3002<\/span><\/p>\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"<\/p>\n

\u5173\u4e8e\u56fd\u5185\u65b0\u836f\u7814\u53d1\u7684IRR\uff0c\u76ee\u524d\u7b14\u8005\u8fd8\u6ca1\u6709\u770b\u5230\u5927\u8303\u56f4\u7684\u6570\u636e\u7edf\u8ba1\uff0c\u53ea\u770b\u5230\u7533\u4e07\u6709\u8fc7\u51e0\u4e2a\u6210\u529f\u6848\u4f8b\u7684\u7edf\u8ba1\uff0cIRR\u56de\u62a5\u7387\u9ad8\u8fbe40%\u4ee5\u4e0a\u3002\u4f46\u56e0\u4e3a\u5e74\u6570\u8fd8\u4e0d\u591f\u957f\uff0c\u7b14\u8005\u5bf9\u7edf\u8ba1\u7684\u65b9\u6cd5\u5b58\u5728\u8d28\u7591\u3002\u62c9\u957f\u65f6\u95f4\u770b\uff0c\u56fd\u5185\u836f\u4f01\u7814\u53d1\u7684IRR\u4e5f\u5c06\u662f\u4e0d\u65ad\u8d70\u4f4e\u7684\u8fc7\u7a0b\uff0c\u56e0\u4e3a\u8fb9\u9645\u6548\u76ca\u9012\u51cf\u89c4\u5f8b\u65e0\u6cd5\u6253\u7834\u3002<\/span><\/p>\n


<\/p>\n

\"\u6df1\u5ea6\uff1a\u65b0\u836f\u7814\u53d1\u6210\u672c\u5927\u63ed\u79d8\"
<\/p>\n

\u516d\u3001\u5168\u6587\u89c2\u70b9\u603b\u7ed3<\/span><\/p>\n

\u00b7 \u56fd\u5916\u836f\u4f01\u5e73\u5747\u5f00\u53d1\u4e2a\u65b0\u836f\u6210\u672c\u5927\u6982\u57288\u4ebf\u7f8e\u91d1\u4ee5\u4e0a\uff0c\u8d44\u672c\u5316\u540e\u7684\u6210\u672c\u9ad8\u8fbe20\u4ebf\u7f8e\u91d1\u3002<\/span><\/p>\n

\u00b7 \u867d\u7136III\u671f\u7684\u4e34\u5e8a\u5f00\u53d1\u6210\u672c\u5de8\u5927\uff0c\u76f8\u53cd\u4e34\u5e8a\u524d\u5f00\u53d1\u6210\u672c\u8f83\u5c0f\uff0c\u4f46\u8003\u8651\u5230\u8d44\u91d1\u7684\u65f6\u95f4\u6210\u672c\u540e\uff0c\u5b9e\u9645\u4e0a\u4e34\u5e8a\u524d\u7684\u5f00\u53d1\u8d39\u7528\u548c\u4e34\u5e8a\u5f00\u53d1\u8d39\u7528\u8d44\u672c\u5316\u540e\uff0c\u76f8\u5dee\u4e0d\u5927\u3002<\/span><\/p>\n

\u00b7 \u5355\u4e2a\u65b0\u836f\u7684\u7814\u53d1\u6210\u672c\u76f8\u5dee\u5de8\u5927\uff0c\u4e14\u4e0d\u540c\u6cbb\u7597\u9886\u57df\u548c\u4e0d\u540c\u4e34\u5e8a\u9636\u6bb5\u5bf9\u65b0\u836f\u4e34\u5e8a\u5f00\u53d1\u6210\u672c\u4e5f\u5b58\u5728\u4e0d\u5c0f\u7684\u5dee\u5f02\u3002<\/span><\/p>\n

\u00b7 \u968f\u7740\u65f6\u95f4\u8fdb\u5c55\uff0c\u56fd\u5916\u65b0\u836f\u5f00\u53d1\u7684\u6210\u672c\u9661\u7136\u4e0a\u5347\uff0c\u6210\u672c\u51e0\u4e4e\u6bcf\u9694\u5341\u5e74\u7ffb\u500d\u3002<\/span><\/p>\n

\u00b7 \u56fd\u5185\u836f\u4f01\u5927\u6982\u5f00\u53d1\u4e00\u4e2a\u65b0\u836f\uff08\u5c0f\u5206\u5b50me-too\uff09\u7684\u6210\u672c\u57282-3\u4ebf\u5143\u5de6\u53f3\uff08\u4e0d\u5305\u542b\u7814\u53d1\u5931\u8d25\u548c\u8d44\u91d1\u673a\u4f1a\u6210\u672c\uff09\uff0c\u4e0e\u56fd\u5916\u7684\u65b0\u836f\u7814\u652f\u51fa\u76f8\u5dee\u5de8\u5927\u3002<\/span><\/p>\n

\u7b14\u8005\u603b\u7ed3\uff1a\u7814\u7a76\u65b0\u836f\u7814\u53d1\u6210\u672c\u7684\u76ee\u7684\uff0c\u66f4\u591a\u7684\u662f\u4fbf\u4e8e\u836f\u4f01\u5728\u65b0\u836f\u7acb\u9879\u65f6\uff0c\u6309\u7167\u4f18\u5148\u987a\u5e8f\uff0c\u5bf9\u4e0d\u540c\u7684\u9879\u76ee\u8fdb\u884c\u76f8\u5bf9\u5e94\u7684\u8d44\u6e90\u914d\u7f6e\u3002\u5bfc\u81f4\u7684\u7ed3\u679c\u662f\uff0c\u65b0\u836f\u6613\u5f97\u7684\u679c\u5b9e\u4e0d\u65ad\u51cf\u5c11\uff0c\u56fd\u5916\u836f\u4f01IRR\u4e0d\u65ad\u4e0b\u964d\u3002\u5728\u4eff\u5236\u836f\u5229\u6da6\u4e0d\u65ad\u7684\u538b\u7f29\u7684\u5927\u80cc\u666f\u4e0b\uff0c\u4f17\u591a\u56fd\u5185\u836f\u4f01\u7eb7\u7eb7\u8f6c\u5411\u521b\u65b0\u836f\u9886\u57df\u3002\u81f3\u4e8e\u56fd\u5185\u836f\u4f01\u7684\u65b0\u836f\u7814\u53d1IRR\u7a76\u7adf\u5230\u8fbe\u4ec0\u4e48\u6837\u7684\u7edd\u5bf9\u503c\uff0c\u4ee5\u53ca\u672a\u6765\u6309\u7167\u4ec0\u4e48\u6837\u7684\u65b9\u5f0f\u8fdb\u884c\u53d1\u5c55\uff0c\u8fd8\u5f97\u7531\u65f6\u95f4\u6765\u5224\u5b9a\u3002<\/span><\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n

[1] DiMasi, Joseph A., G. G. Henry, and W. H. Ronald. “Briefing: cost of developing a new drug.” Tufts Center for the Study of Drug Development (2014).<\/span><\/span><\/p>\n

[2] Paul, Steven M., et al. “How to improve R&D productivity: the pharmaceutical industry’s grand challenge.” Nature reviews Drug discovery 9.3 (2010): 203.<\/span><\/span><\/p>\n

[3] Prasad, Vinay, and Sham Mailankody. “Research and development spending to bring a single cancer drug to market and revenues after approval.” JAMA internal medicine 177.11 (2017): 1569-1575.<\/span><\/span><\/p>\n

[4] Examination of clinical trial costs and barriers for drug development<\/span><\/span><\/p>\n

[5] Morgan, Steve, et al. “The cost of drug development: a systematic review.” Health policy 100.1 (2011): 4-17<\/span><\/span><\/p>\n


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<\/p>\n

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\u8fd1\u671f\u57f9\u8bad\u70b9\u51fb\u53f3\u4fa7\u4f1a\u8bae\u94fe\u63a5\u5373\u53ef\u9605\u8bfb\u539f\u6587 <\/span>  <\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\n\n\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u5730\u70b9<\/span><\/th>\n\u65f6\u95f4<\/span><\/th>\n\u4f1a\u8bae\u94fe\u63a5<\/span><\/th>\n<\/tr>\n
\u676d\u5dde<\/span><\/strong><\/td>\n10\u670811<\/span>-13<\/span>\u65e5<\/span><\/span><\/strong><\/td>\n\n

\u676d\u5dde<\/span>-2018\u201ccGMP\u6587\u4ef6\u7f16\u5236\u89c4\u8303<\/span>\u201d<\/span>\u4e13\u9898\u7814\u4fee\u73ed\u7684\u901a\u77e5<\/span><\/span><\/span><\/a><\/p>\n<\/td>\n<\/tr>\n

\u4e0a\u6d77<\/span><\/strong><\/td>\n<\/span>10\u670812<\/span>-14<\/span>\u65e5<\/span><\/span><\/strong><\/span><\/td>\n\n

\u4e0a\u6d77<\/span>–\u7b2c\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7528\u836f<\/span>GMP<\/span>\u5236\u5ea6\u8981\u70b9\u89e3\u6790\u53ca\u5e94\u7528\u5b9e\u65bd\u4e13\u9898\u57f9\u8bad\u73ed<\/span><\/span><\/span><\/a><\/p>\n<\/td>\n<\/tr>\n

\u6b66\u6c49<\/span><\/strong><\/td>\n10\u670819<\/span>-21<\/span>\u65e5<\/span><\/span><\/strong><\/td>\n\n

\u6b66\u6c49<\/span>\u201c\u836f\u4f01\u7ea0\u6b63\u4e0e\u9884\u9632\u63aa\u65bd\u5b9e\u65bd\u4e0e\u6539\u8fdb\u4e13\u9898\u57f9\u8bad\u73ed<\/span>\u201d<\/span><\/span><\/span><\/a><\/p>\n<\/td>\n<\/tr>\n

\u4e0a\u6d77<\/span><\/strong><\/span><\/td>\n10\u670819-21\u65e5<\/span><\/td>\n\n

\u4e0a\u6d77\u4e3e\u529e<\/span>\u201c\u5316\u5b66\u539f\u6599\u836f\u5236\u5907\u5de5\u827a\u5f00\u53d1\u5173\u952e\u63a7\u5236\u4e0e\u8d28\u91cf\u7814\u7a76\u5b9e\u8df5\u201d\u7814\u4fee\u73ed<\/a><\/span><\/span><\/p>\n<\/td>\n<\/tr>\n

\u676d\u5dde<\/span><\/td>\n10\u6708<\/span>25-27<\/span>\u65e5<\/span><\/span><\/strong><\/td>\n\n

\u676d\u5dde<\/span>–\u7b2c\u4e8c\u671f<\/span>2018<\/span>\u836f\u4f01<\/span>oos\/oot<\/span>\u8c03\u67e5\u8bef\u533a\u4e0e\u6539\u8fdb\u5b9e\u64cd\u4e13\u9898\u57f9\u8bad\u73ed<\/span><\/span><\/span><\/a><\/p>\n<\/td>\n<\/tr>\n

<\/span>\u5317\u4eac<\/span><\/td>\n10\u6708<\/span>24-26<\/span>\u65e5<\/span><\/span><\/strong><\/td>\n\n

\u5317\u4eac\u4e3e\u529e\u6ee1\u8db3\u6b27\u7f8e\u6807\u51c6\u7684\u4eff\u5236\u836f\u7814\u53d1\u4f53\u7cfb\u642d\u5efa\u7814\u8ba8\u73ed<\/span><\/span><\/span><\/a><\/p>\n<\/td>\n<\/tr>\n

\u5357\u4eac<\/strong><\/td>\n10\u6708<\/span>25-27<\/span>\u65e5<\/span><\/span><\/strong><\/td>\n\n

\u5357\u4eac<\/span>–\u4e3e\u529e<\/span>\u2018<\/span>\u836f\u7269\u7814\u53d1\u8d28\u91cf\u7ba1\u7406\u8fd0\u884c\u4e2d\u7684\u96be\u70b9\u5b9e\u65bd\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u7528\u836f\u7269<\/span>GMP<\/span>\u5b9e\u65bd\u5173\u952e\u70b9\u63a7\u5236<\/span>\u2019<\/span>\u9ad8\u7ea7\u7814\u4fee\u73ed<\/span><\/span><\/span><\/a><\/p>\n<\/td>\n<\/tr>\n

\u676d\u5dde<\/strong><\/span><\/span><\/td>\n10\u6708<\/span>25-27<\/span>\u65e5<\/span><\/span><\/strong><\/td>\n\n

\u676d\u5dde<\/span>2018\u5e74\u529f\u80fd\u98df\u54c1<\/span>.<\/span>\u539f\u6599\u521b\u65b0\u4e0e\u6d3b\u6027\u6210\u5206\u5e94\u7528\u6280\u672f\u4e3b\u9898\u5cf0\u4f1a<\/span><\/span><\/span><\/a><\/p>\n

<\/span><\/strong><\/span><\/td>\n<\/tr>\n

<\/span>\u4e0a\u6d77<\/span><\/td>\n10\u6708<\/span>26-28<\/span>\u65e5<\/span><\/span><\/strong><\/td>\n\n

\u4e0a\u6d77\u4e3e\u529e<\/span>2018\u836f\u4f01\u8d28\u91cf\u8c03\u67e5\u6280\u672f\u6307\u5bfc\u4e13\u9898\u57f9\u8bad\u73ed<\/span><\/span><\/span><\/a><\/p>\n<\/td>\n<\/tr>\n

\u6d4e\u5357<\/span><\/td>\n10\u6708<\/span>26-28<\/span>\u65e5<\/span><\/span><\/strong><\/td>\n\n

\u6d4e\u5357<\/span>–\u7b2c\u4e8c\u671f\u5b9e\u9a8c\u5ba4\u7814\u53d1<\/span>qc<\/span>\u89c4\u8303\u7ba1\u7406\u4e0e<\/span>lch<\/span>\u6307\u5357\u53ca\u836f\u5178\u6700\u65b0\u8fdb\u5c55\u7814\u4fee\u73ed<\/span><\/span><\/span><\/a><\/p>\n<\/td>\n<\/tr>\n

\u5357\u4eac<\/strong><\/td>\n10\u6708<\/span>27-29<\/span>\u65e5<\/span><\/span><\/strong><\/td>\n\n

\u5357\u4eac<\/span>–\u5236\u836f\u4f01\u4e1a\u5982\u4f55\u5b9e\u73b0<\/span>gmp<\/span>\u6709\u6548\u8fd0\u8425\u6c9f\u901a\u9ad8\u7ea7\u7814\u8ba8\u4f1a<\/span><\/span><\/span><\/a><\/p>\n<\/td>\n<\/tr>\n

\u4e0a\u6d77<\/span><\/strong><\/td>\n10\u670812-14<\/span>\u65e5<\/span><\/strong><\/td>\n\n

\u4e0a\u6d77<\/span>–\u7b2c\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7528\u836f<\/span>GMP\u5236\u5ea6\u8981\u70b9\u89e3\u6790\u53ca\u5e94\u7528\u5b9e\u65bd\u4e13\u9898\u57f9\u8bad\u73ed<\/span><\/span><\/span><\/a><\/p>\n<\/td>\n<\/tr>\n

\u6b66\u6c49<\/span><\/strong><\/td>\n\n

10\u670819-21<\/span>\u65e5<\/span><\/strong><\/span><\/p>\n


<\/p>\n<\/td>\n

\n

\u6b66\u6c49<\/span>\u201c\u836f\u4f01\u7ea0\u6b63\u4e0e\u9884\u9632\u63aa\u65bd\u5b9e\u65bd\u4e0e\u6539\u8fdb\u4e13\u9898\u57f9\u8bad\u73ed<\/span>\u201d<\/span><\/a><\/p>\n<\/td>\n<\/tr>\n

\u91cd\u5e86<\/span><\/strong><\/td>\n11\u67081<\/span>-3<\/span>\u65e5<\/span><\/span><\/strong><\/td>\n\n

\u91cd\u5e86<\/span>–\u836f\u54c1\u5236\u5907\u5de5\u827a\u5f00\u53d1\u4e0e\u5de5\u827a\u9a8c\u8bc1<\/span>\/<\/span>\u6301\u7eed\u5de5\u827a\u786e\u5b9a\u7814\u7a76\u4e0e\u5b9e\u65bd\u7814\u4fee\u73ed<\/span><\/a><\/span><\/span><\/p>\n<\/td>\n<\/tr>\n

\u676d\u5dde<\/span><\/strong><\/td>\n11\u67081<\/span>-3<\/span>\u65e5<\/span><\/span><\/strong><\/td>\n\n

\u676d\u5dde<\/span>–<\/span><\/span>\u4e3e\u529e<\/span>2018<\/span>\u533b\u836f\u5316\u5de5\u5b89\u5168\u751f\u4ea7\u4e0e\u5de5\u827a\u5b89\u5168\u7ba1\u7406\u7814\u8ba8\u73ed<\/span><\/a><\/span><\/span><\/p>\n


<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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