{"id":56260,"date":"2018-09-29T01:00:00","date_gmt":"2018-09-30T02:13:38","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e4%ba%ba%e7%b1%bb%e9%aa%a8%e9%aa%bc%e5%b9%b2%e7%bb%86%e8%83%9e%e7%bb%88%e4%ba%8e%e8%a2%ab%e9%89%b4%e5%ae%9a%e5%87%ba%e6%9d%a5\/"},"modified":"2018-09-30T10:13:39","modified_gmt":"2018-09-30T02:13:39","slug":"%e4%ba%ba%e7%b1%bb%e9%aa%a8%e9%aa%bc%e5%b9%b2%e7%bb%86%e8%83%9e%e7%bb%88%e4%ba%8e%e8%a2%ab%e9%89%b4%e5%ae%9a%e5%87%ba%e6%9d%a5","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/56260\/","title":{"rendered":"\u4eba\u7c7b\u9aa8\u9abc\u5e72\u7ec6\u80de\u7ec8\u4e8e\u88ab\u9274\u5b9a\u51fa\u6765"},"content":{"rendered":"
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\"\u4eba\u7c7b\u9aa8\u9abc\u5e72\u7ec6\u80de\u7ec8\u4e8e\u88ab\u9274\u5b9a\u51fa\u6765\"<\/p>\n

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2015\u5e74\uff0c\u901a\u8fc7\u8c31\u7cfb\u8ffd\u8e2a\u548c\u514b\u9686\u5206\u6790\u7b49\u624b\u6bb5\uff0c\u79d1\u5b66\u5bb6\u627e\u5230\u4e86\u5c0f\u9f20\u9aa8\u9abc\u5e72\u7ec6\u80de\uff08mouse SSCs\uff0cmSSCs\uff09\u5b58\u5728\u7684\u8bc1\u636e\u30103-5\u3011\u3002\u6700\u8fd1\uff0c\u4eba\u7c7b\u9aa8\u9abc<\/span>\u5e72\u7ec6\u80de<\/span>\uff08human skeletal stem cell\uff0chSSC\uff09\u7ec8\u4e8e\u88ab\u9996\u6b21\u9274\u5b9a\uff0c\u8be5\u5de5\u4f5c\u4e8e9\u670820\u65e5\u4ee5Identification of the Human Skeletal Stem Cell\u4e3a\u9898\u53d1\u8868\u5728Cell\u6742\u5fd7\u4e0a\uff0c\u7531\u65af\u5766\u798f\u533b\u5b66Michael T. Longaker\u56e2\u961f\u5b8c\u6210\u3002\u8fd9\u9879\u5de5\u4f5c\u4e3b\u8981\u5305\u62echSSC\u7684\u5206\u79bb\u548c\u76f8\u5173\u529f\u80fd\u68c0\u9a8c\u3001\u4e2a\u4f53hSSC\u57fa\u56e0\u8868\u8fbe\u5206\u6790\u4ee5\u53ca\u9a71\u52a8\u9aa8\u9abc\u53d1\u751f\u8fc7\u7a0b\u7684\u8fdb\u5316\u8d8b\u540c\u6216\u8d8b\u5f02\u901a\u8def\u5206\u6790\u3002<\/span><\/p>\n

\u9996\u5148\uff0c\u7814\u7a76\u53d1\u73b0\u4e86\u4eba\u7c7b\u9aa8\u9abc\u5e72\u7ec6\u80de\u7684\u53d1\u5c55\u5c42\u7ea7\u3002hSSC\u7684\u6807\u5fd7\u6027\u86cb\u767d\u7531PDPN\u3001CD146\u3001CD73\u548cCD164\u7ec4\u6210\uff0c\u7eaf\u5316\u51fa\u7684PDPN+CD146-CD73+CD164+\u7ec6\u80de\u7fa4\u843d\uff0c\u5728\u4f53\u5916\u5177\u6709\u81ea\u6211\u66f4\u65b0\u7684\u80fd\u529b\uff08\u8be5\u7814\u7a76\u901a\u8fc7\u8fde\u7eed\u4ea7\u751f\u7ec6\u80de\u7fa4\u843d\u5f62\u6210\u5355\u4f4d\uff08colony forming units\uff0cCFUs\uff09\u7684\u80fd\u529b\u8868\u5f81\uff09\uff0c\u5728\u5c0f\u9f20\u80be\u4e0b\u79fb\u690d\uff0c\u80fd\u591f\u7ebf\u6027\u5730\u5206\u5316\u51fa\u542b\u6709\u9aa8\u3001\u8f6f\u9aa8\u548c\u57fa\u8d28\u7684\u591a\u5411\u6027\u5c0f\u9aa8\uff08multilineage ossicles\uff09\uff1a\u9996\u5148\u5206\u5316\u51fa\u65e9\u671f\u9aa8\u3001\u8f6f\u9aa8\u548c\u57fa\u8d28\u7684\u7956\u7ec6\u80de\uff08hBCSP\uff09\uff0c\u63a5\u7740\u662f\u9aa8\u7956\u7ec6\u80de\uff08hOP\uff09\u548c\u8f6f\u9aa8\u7956\u7ec6\u80de\uff08hCP\uff09\uff0c\u6700\u540e\u624d\u5206\u5316\u51fa\u9aa8\u9abc\u3001\u8f6f\u9aa8\u548c\u57fa\u8d28\u7ec6\u80de\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0chSSCs\u4e0d\u4f1a\u5206\u5316\u4e3a\u8102\u80aa\u7ec6\u80de\uff08\u8868\u660e\u8102\u80aa\u7ec6\u80de\u53ef\u80fd\u6765\u6e90\u5176\u4ed6\u5e38\u9a7b\u7684\u9aa8\u9ad3<\/span>\u5e72\u7ec6\u80de<\/span>\uff09\u3002<\/span><\/p>\n

\u901a\u8fc7\u65b0\u5efa\u7acb\u7684\u4eba\u9aa8\u5f02\u79cd\u79fb\u690d\u5c0f\u9f20\u6a21\u578b\uff08\u5c0618\u5468\u80ce\u513f\u5e26\u5b8c\u6574\u9aa8\u819c\u7684\u6307\u9aa8\u79fb\u690d\u7269\u79fb\u690d\u52305\u65e5\u9f84\u7684\u514d\u75ab\u7f3a\u9677NSG\u5c0f\u9f20\u4e2d\u6240\u5f97\uff09\uff0c\u7814\u7a76\u8005\u5728\u76f8\u5bf9\u53ef\u63a7\u7684\u73af\u5883\u4e2d\u8bc4\u4f30\u4e86\u635f\u4f24\u5bf9\u4eba\u4f53\u80a2\u4f53\u9aa8\u9abc\u7684\u5f71\u54cd\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u6025\u6027\u9aa8\u9abc\u635f\u4f24\u540e\uff0chSSCs\u4f1a\u5728\u635f\u4f24\u90e8\u4f4d\u53d1\u751f\u663e\u7740\u7684\u5c40\u90e8\u6269\u5f20\uff0c\u8fd9\u8bc1\u660e\u4e86hSSCs\u4f5c\u4e3a<\/span>\u5e72\u7ec6\u80de<\/span>\u5bf9\u9aa8\u9abc\u635f\u4f24\u7684\u518d\u751f\u53cd\u5e94\u3002<\/span><\/p>\n

\u5173\u4e8e\u9020\u8840\u652f\u6301\u529f\u80fd\u7684\u8bd5\u9a8c\u8868\u660e\uff0chSSC\u5206\u5316\u51fa\u7684\u57fa\u8d28\u53ef\u4ee5\u5728\u65e0\u8840\u6e05\u57f9\u517b\u6761\u4ef6\u4e0b\u7ef4\u6301\u4eba\u9020\u8840<\/span>\u5e72\u7ec6\u80de<\/span>\uff08hHSCs\uff09\u7684\u751f\u957f\u3002\u7814\u7a76\u8005\u8fd8\u53d1\u73b0\u4e86hSSCs\u548chSSC\u884d\u751f\u7ec6\u80de\u7fa4\u80fd\u591f\u8868\u8fbe\u591a\u79cd\u6f5c\u5728\u7684\u9020\u8840\u652f\u6301\u7ec6\u80de\u56e0\u5b50\uff0c\u5305\u62ecANGPT1\uff0cCSF1\uff0cSDF\uff0cIL27\uff0cIL7\u548cSCF\uff1b\u5bf9\u5e94\u7684\uff0chHSCs\u4e5f\u8868\u8fbe\u4e86\u591a\u79cd\u53ef\u80fd\u652f\u6301hSSC\u7ec6\u80de\u7cfb\u7684\u56e0\u5b50\uff0c\u5305\u62ecBMP2\uff0cBMP8A\uff0cDHH\uff0cFGF3\uff0cWNT1\u548cWNT8\u3002<\/span><\/p>\n

\u7b2c\u4e8c\uff0c\u7814\u7a76\u53d1\u73b0\uff0chSSC\u53ca\u5176\u4e0b\u6e38\u5206\u5316\u7ec6\u80de\u4e0d\u4ec5\u53ef\u4ee5\u4ece\u80ce\u513f\u548c\u6210\u4eba\u7684\u9aa8\u9abc\u4e2d\u6210\u529f\u5206\u79bb\uff0c\u4e5f\u80fd\u591f\u4eceBMP2\u5904\u7406\u7684\u4eba\u8102\u80aa\u57fa\u8d28\uff08BMP2-treated human adipose stroma\uff0cB-HAS\uff09\u548c\u8bf1\u5bfc\u591a\u80fd<\/span>\u5e72\u7ec6\u80de<\/span>\uff08induced pluripotent stem cells\uff0c<\/span>ips<\/span>C\uff09\u4e2d\u83b7\u5f97\u3002\u901a\u8fc7scRNA-seq\u5b9a\u91cf\u5206\u6790\uff0c\u53d1\u73b0\u80ce\u513f\u548c\u6210\u4eba\u7684hSSCs\u5206\u5316\u65f6\u7684\u57fa\u56e0\u8868\u8fbe\u5b58\u5728\u5dee\u5f02\uff0c\u53ef\u4ee5\u4e00\u5b9a\u7a0b\u5ea6\u89e3\u91ca\u4e0d\u540c\u6765\u6e90hSSC\u5f62\u6210\u7684\u5c0f\u9aa8\u4e2d\uff0c\u8f6f\u9aa8\u548c\u9aa8\u7684\u6bd4\u4f8b\u4e0d\u540c\u7684\u73b0\u8c61\u3002<\/span><\/p>\n

\u7b2c\u4e09\uff0c\u8be5\u7814\u7a76\u901a\u8fc7\u6bd4\u8f83\u5c0f\u9f20\u548c\u4e0e\u4eba\u7c7bSSCs\u5728\u8f6c\u5f55\u7ec4\u5b66\u548c<\/span>\u8868\u89c2\u9057\u4f20\u5b66<\/span>\u4e0a\u7684\u533a\u522b\uff0c\u53d1\u73b0\u4e86<\/span>\u5e72\u7ec6\u80de<\/span>\u4ecb\u5bfc\u7684\u9aa8\u9abc\u5f62\u6210\u5728\u8fdb\u5316\u4e0a\u4fdd\u5b88\u7684\u8c03\u8282\u901a\u8def\uff0c\u4ee5\u53ca\u53e6\u4e00\u4e9b\u8d8b\u5f02\u7684\u5206\u5b50\u901a\u8def\uff0c\u540e\u8005\u53ef\u80fd\u5728\u9aa8\u9abc\u53d1\u80b2\u4e2d\u8d77\u5230\u8c03\u8282\u7269\u79cd\u7279\u5f02\u6027\u7684\u4f5c\u7528\u3002<\/span><\/p>\n

\u603b\u7684\u6765\u8bf4\uff0c\u901a\u8fc7\u5bf9\u5c0f\u9f20\u548c\u4eba\u7c7bSSC\u53ca\u5176\u4e0b\u6e38\u9aa8\u9abc\u7ec6\u80de\u8c31\u7cfb\u7684\u9274\u5b9a\uff0c\u8fd9\u9879\u7814\u7a76\u4e3a\u6211\u4eec\u63cf\u7ed8\u51fa<\/span>\u5e72\u7ec6\u80de<\/span>\u4ecb\u5bfc\u7684\u4eba\u4f53\u9aa8\u9abc\u7ec4\u7ec7\u5f62\u6210\u7684\u7ec6\u80de\u8c31\u7cfb\u56fe\uff0c\u4e3a\u672a\u6765\u7814\u7a76\u9aa8\u9abc\u5f62\u6210\u3001\u53d1\u80b2\u7684<\/span>\u9057\u4f20<\/span>\u548c\u5206\u5b50\u51b3\u5b9a\u56e0\u7d20\u6253\u4e0b\u4e86\u57fa\u7840\uff0c\u63a8\u8fdb\u4e86\u9aa8\u9abc\u75be\u75c5\u5206\u5b50<\/span>\u8bca\u65ad<\/span>\u548c\u6cbb\u7597\u7684\u53d1\u5c55\uff0c\u6709\u5229\u4e8e\u7f13\u89e3\u9000\u884c\u6027\u3001<\/span>\u80bf\u7624<\/span>\u6027\u3001\u521b\u4f24\u540e\u6216\u624b\u672f\u540e\u7684\u591a\u79cd\u9aa8\u9abc\u75be\u75c5\u7ed9\u4eba\u7c7b\u5e26\u6765\u7684\u5de8\u5927\u533b\u7597\u8d1f\u62c5\u3002<\/span><\/p>\n

\u8f6c\u8f7d\u81ea\uff1aBioArt<\/span>   \u5982\u6709<\/span>\u4fb5\u6743\u8bf7\u8054\u7cfb\u5220\u9664<\/span><\/p>\n


<\/span><\/p>\n

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