{"id":56382,"date":"2018-09-26T01:00:00","date_gmt":"2018-09-30T02:14:39","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e5%a4%9a%e7%af%87%e6%96%87%e7%ab%a0%e8%81%9a%e7%84%a6t%e7%bb%86%e8%83%9e%e9%87%8d%e7%a3%85%e7%ba%a7%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%ef%bc%81\/"},"modified":"2018-09-30T10:14:41","modified_gmt":"2018-09-30T02:14:41","slug":"%e5%a4%9a%e7%af%87%e6%96%87%e7%ab%a0%e8%81%9a%e7%84%a6t%e7%bb%86%e8%83%9e%e9%87%8d%e7%a3%85%e7%ba%a7%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%ef%bc%81","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/56382\/","title":{"rendered":"\u591a\u7bc7\u6587\u7ae0\u805a\u7126T\u7ec6\u80de\u91cd\u78c5\u7ea7\u7814\u7a76\u6210\u679c\uff01"},"content":{"rendered":"
\n

\u672c\u6587\u4e2d\uff0c\u5c0f\u7f16\u5bf9\u8fd1\u671f\u79d1\u5b66\u5bb6\u4eec\u5728T\u7ec6\u80de\u9886\u57df\u7684\u91cd\u8981\u7814\u7a76\u6210\u679c\u8fdb\u884c\u6574\u7406\uff0c\u5206\u4eab\u7ed9\u5927\u5bb6\uff01<\/strong><\/span><\/p>\n

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\u30101\u3011<\/span>Science\uff1a\u91cd\u78c5\uff01\u63ed\u793aT\u7ec6\u80de\u547d\u8fd0\u51b3\u5b9a\u673a\u5236<\/span><\/p>\n

doi\uff1a10.1126\/science.aao2933<\/strong><\/span><\/p>\n

\u5728\u75c5\u539f\u4f53\u611f\u67d3\u8eab\u4f53\u540e\uff0c\u514d\u75ab\u7cfb\u7edf\u4f1a\u53d1\u751f\u4e00\u7cfb\u5217\u663e\u8457\u7684\u4e14\u975e\u5e38\u590d\u6742\u7684\u4e8b\u4ef6\u3002\u4e00\u4e9b\u79f0\u4e3a\u6dcb\u5df4\u7ec6\u80de\u7684\u514d\u75ab\u7ec6\u80de\u8fc1\u79fb\u5230\u611f\u67d3\u90e8\u4f4d\uff1b\u5176\u4ed6\u7684\u514d\u75ab\u7ec6\u80de\u8fc1\u79fb\u5230\u6297\u4f53\u80fd\u591f\u5f00\u59cb\u4ea7\u751f\u7684\u6dcb\u5df4\u7ed3\u533a\u57df\u3002\u901a\u8fc7\u7ec6\u80de\u95f4\u63a5\u89e6\u548c\u4fe1\u53f7\u5206\u5b50\u91ca\u653e\uff0c\u5927\u91cf\u7684\u4fe1\u53f7\u8f6c\u5bfc\u5728\u514d\u75ab\u7ec6\u80de\u4e2d\u53d1\u751f\u7740\u3002\u8fd9\u4e9b\u514d\u75ab\u53cd\u5e94\u7684\u76ee\u6807\u662f\u7834\u574f\u75c5\u539f\u4f53\u548c\u4fee\u590d\u7ec4\u7ec7\u635f\u4f24\u3002<\/span><\/p>\n

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\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u963f\u62c9\u5df4\u9a6c\u5927\u5b66\u4f2f\u660e\u7ff0\u5206\u6821\u3001\u54c8\u68ee\u963f\u5c14\u6cd5\u751f\u7269\u6280\u672f\u7814\u7a76\u6240\u3001\u9ebb\u7701\u603b\u533b\u9662\u3001\u54c8\u4f5b\u533b\u5b66\u9662\u548c\u8f9b\u8f9b\u90a3\u63d0\u513f\u7ae5\u533b\u9662\u7684\u7814\u7a76\u4eba\u5458\u8be6\u7ec6\u4ecb\u7ecd\u4e86\u4e00\u79cd\u4e3a\u4ea7\u751f\u4e24\u79cd\u4e3b\u8981\u7684\u6548\u5e94\u7ec6\u80de\u4e9a\u7fa4— Tfh\u7ec6\u80de\u548c\u975eTfh\u7ec6\u80de—\u7684\u547d\u8fd0\u51b3\u5b9a\u4f5c\u597d\u51c6\u5907\u7684\u673a\u5236\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u57282018\u5e749\u670814\u65e5\u7684Science\u671f\u520a\u4e0a\u3002<\/span><\/p>\n

\u30102\u3011<\/span>Sci Immunol\uff1aT\u7ec6\u80de\u884c\u4e3a\u65b0\u53d1\u73b0\u6709\u671b\u5e2e\u52a9\u5f00\u53d1\u6cbb\u7597\u764c\u75c7\u7684\u65b0\u578b\u514d\u75ab\u7597\u6cd5<\/span><\/p>\n

doi\uff1a10.1126\/sciimmunol.aas9822<\/strong><\/span><\/p>\n

\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Science Immunology\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u79d1\u7f57\u62c9\u591a\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff0c\u4ece\u75ab\u82d7\u4e2d\u83b7\u5f97\u7684\u62b5\u5fa1\u75be\u75c5\u7684T\u7ec6\u80de\u6216\u8bb8\u5e76\u4e0d\u9700\u8981\u8461\u8404\u7cd6\u6765\u5feb\u901f\u7e41\u6b96\uff0c\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u6216\u8bb8\u5bf9\u4e8e\u5f00\u53d1\u764c\u75c7\u60a3\u8005\u7684\u65b0\u578b\u514d\u75ab\u7597\u6cd5\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u548c\u5e0c\u671b\u3002<\/span><\/p>\n

\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5bf9\u63a5\u79cd\u4e9a\u5355\u4f4d\u75ab\u82d7\u7684\u60a3\u8005\u8fdb\u884c\u5206\u6790\uff0c\u68c0\u6d4b\u4e86\u5176\u673a\u4f53\u514d\u75ab\u7cfb\u7edf\u4e2d\u6240\u4ea7\u751f\u7684T\u7ec6\u80de\uff0c\u5236\u4f5c\u8fd9\u79cd\u75ab\u82d7\u53ea\u4f1a\u5229\u7528\u81f4\u75c5\u75c5\u6bd2\u7684\u4e00\u90e8\u5206\u6765\u8fdb\u884c\uff1b\u7814\u7a76\u8005\u53d1\u73b0\uff0c\u653b\u51fb\u548c\u6291\u5236\u611f\u67d3\u53d1\u751f\u7684\u5173\u952e\u767d\u7ec6\u80de\uff08T\u7ec6\u80de\uff09\u5e76\u4e0d\u4f1a\u4f9d\u8d56\u8461\u8404\u7cd6\u6765\u52a0\u901f\u7ec6\u80de\u7684\u5feb\u901f\u5206\u88c2\uff0c\u7ec6\u80de\u5206\u88c2\u4f1a\u6bcf\u96942-4\u5c0f\u65f6\u53d1\u751f\u4e00\u6b21\uff0c\u76f8\u53cd\u8fd9\u4e9b\u767d\u7ec6\u80de\u4f1a\u5229\u7528\u7ebf\u7c92\u4f53\u6765\u652f\u6301\u7ec6\u80de\u7684\u751f\u957f\u53ca\u5206\u88c2\u3002<\/span><\/p>\n

\"\u591a\u7bc7\u6587\u7ae0\u805a\u7126T\u7ec6\u80de\u91cd\u78c5\u7ea7\u7814\u7a76\u6210\u679c\uff01\"<\/p>\n

\u30103\u3011<\/span>Science\u5b50\u520a\uff1a\u9996\u6b21\u5bf9CAR-T\u7ec6\u80de\u4fe1\u53f7\u8fdb\u884c\u6df1\u5ea6\u5206\u6790\uff0c\u6709\u52a9\u6539\u8fdbT\u7ec6\u80de\u514d\u75ab\u6cbb\u7597<\/span><\/p>\n

doi\uff1a10.1126\/scisignal.aat6753<\/strong><\/span><\/p>\n

\u5bf9\u514d\u75ab\u7ec6\u80de\u8fdb\u884c\u91cd\u7f16\u7a0b\u4f7f\u5f97\u5b83\u4eec\u62b5\u6297\u764c\u75c7\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u5df2\u5728\u4e00\u4e9b\u5bf9\u5176\u4ed6\u6cbb\u7597\u6ca1\u6709\u4f5c\u51fa\u53cd\u5e94\u7684\u8840\u764c\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u5de8\u5927\u7684\u5e0c\u671b\u3002\u4f46\u662f\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u4eba\u4eec\u4ecd\u7136\u6ca1\u6709\u5f7b\u5e95\u7814\u7a76\u80fd\u591f\u5bfc\u81f4\u6297\u764c\u53cd\u5e94\u4ea7\u751f\u7684\u751f\u7269\u5b66\u901a\u8def\u3002<\/span><\/p>\n

\u4e86\u89e3\u8fd9\u4e9b\u901a\u8def\u5bf9\u8bbe\u8ba1\u672a\u6765\u51e0\u4ee3\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u662f\u975e\u5e38\u91cd\u8981\u7684\uff0c\u5305\u62ec\u51cf\u5c11\u526f\u4f5c\u7528\u3001\u963b\u6b62\u6cbb\u7597\u540e\u590d\u53d1\uff0c\u4ee5\u53ca\u8ba9\u5b83\u6709\u6548\u5730\u62b5\u6297\u66f4\u4e3a\u5e38\u89c1\u7684\u764c\u75c7\uff0c\u5982\u5b9e\u4f53\u7624\u3002<\/span><\/p>\n

\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u5f17\u96f7\u5fb7-\u54c8\u91d1\u68ee\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\uff08Fred Hutch\uff09\u7684\u7814\u7a76\u4eba\u5458\u6bd4\u8f83\u4e86\u4e24\u79cd\u4e0d\u540c\u7684CAR\uff08chimeric antigen receptor\uff0c \u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff09\u8bbe\u8ba1\u4e2d\u7684T\u7ec6\u80de\u4fe1\u53f7\u6a21\u5f0f\u3002\u8fd9\u662f\u9996\u6b21\u6bd4\u8f83<\/span>\u4e34\u5e8a\u8bd5\u9a8c<\/span>\u4e2d\u4f7f\u7528\u7684\u4e24\u79cd\u5e38\u89c1\u7684CAR\u8bbe\u8ba1\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u57282018\u5e748\u670821\u65e5\u7684Science Signaling\u671f\u520a\u4e0a\u3002<\/span><\/p>\n

\u30104\u3011<\/span>Sci Rep\uff1a\u9274\u5b9a\u51faT\u7ec6\u80de\u7684\u708e\u6027\u751f\u7269\u6807\u5fd7\u7269<\/span><\/p>\n

doi\uff1a10.1038\/s41598-018-29262-4<\/strong><\/span><\/p>\n

\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u9a6c\u6b47\u5c14\u5927\u5b66\u836f\u5b66\u9662\u548c\u9a6c\u6b47\u5c14\u5927\u5b66\u743c-\u7231\u5fb7\u534e\u5179\u533b\u5b66<\/span>\u57fa\u56e0\u7ec4\u5b66<\/span>\u6838\u5fc3\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u63a2\u7a76\u4e86\u4ebaT\u7ec6\u80de\u5728\u708e\u75c7\u6761\u4ef6\u4e0b\u7684\u529f\u80fd\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e747\u670819\u65e5\u53d1\u8868\u5728Scientific Reports\u671f\u520a\u4e0a\u3002<\/span><\/p>\n

\u8bba\u6587\u901a\u4fe1\u4f5c\u8005\u3001\u9a6c\u6b47\u5c14\u5927\u5b66\u836f\u5b66\u9662\u52a9\u7406\u6559\u6388Jeremy P. McAleer\u535a\u58eb\u8bf4\uff0c\u201c\u6211\u4eec\u5bf9T\u7ec6\u80de\u57fa\u56e0\u8868\u8fbe\u7684\u5206\u6790\u4e3a\u7814\u7a76\u73af\u5883\u4ea7\u7269\u5982\u4f55\u63a7\u5236T\u7ec6\u80de\u6d3b\u5316\u548c\u4fc3\u708e\u529f\u80fd\u63d0\u4f9b\u4e86\u8bb8\u591a\u6f5c\u5728\u7684\u9776\u6807\u3002\u5907\u53d7\u9f13\u821e\u7684\u662f\uff0c\u6211\u4eec\u53d1\u73b0\u5176\u4e2d\u7684\u4e00\u79cd\u9776\u6807\uff0c\u5373GPR68\uff0c\u8c03\u8282T\u7ec6\u80de\u4ea7\u751f\u5316\u5b66\u4fe1\u4f7f\u5206\u5b50\u7684\u80fd\u529b\u3002\u8fd9\u53ef\u80fd\u5bf9\u7c98\u819c\u8868\u9762\uff08\u6bd4\u5982\u6765\u81ea\u80ba\u90e8\u548c\u80c3\u80a0\u9053\uff09\u4e0a\u7684\u75be\u75c5\u4ea7\u751f\u5f71\u54cd\u3002\u201d<\/span><\/p>\n

\"\u591a\u7bc7\u6587\u7ae0\u805a\u7126T\u7ec6\u80de\u91cd\u78c5\u7ea7\u7814\u7a76\u6210\u679c\uff01\"<\/p>\n

\u30105\u3011<\/span>JCI\uff1a\u79d1\u5b66\u5bb6\u627e\u5230\u8c03\u8282T\u7ec6\u80de\u8fc1\u79fb\u514b\u5236\u514d\u75ab\u6392\u65a5\u7684\u91cd\u8981\u9776\u70b9<\/span><\/p>\n

doi\uff1a10.1172\/JCI120972<\/strong><\/span><\/p>\n

\u4f17\u6240\u5468\u77e5\uff0cT\u7ec6\u80de\u5fc5\u987b\u901a\u8fc7\u8fc1\u79fb\u624d\u80fd\u4e0e\u6297\u539f\u9012\u5448\u7ec6\u80de\u76f8\u9047\uff0c\u6267\u884c\u5b83\u4eec\u5728\u514d\u75ab\u9632\u5fa1\u548c\u708e\u75c7\u65b9\u9762\u7684\u591a\u79cd\u529f\u80fd\u3002ATP\u91ca\u653e\u548c\u901a\u8fc7\u560c\u5464\u53d7\u4f53\u4ecb\u5bfc\u7684\u81ea\u5206\u6ccc\u4fe1\u53f7\u80fd\u591f\u4fc3\u8fdbT\u7ec6\u80de\u5728\u4e0e\u6297\u539f\u9012\u5448\u7ec6\u80de\u5f62\u6210\u7684\u514d\u75ab\u7a81\u89e6\u4f4d\u7f6e\u7684\u6fc0\u6d3b\u3002\u8fd1\u65e5\u6765\u81ea\u7f8e\u56fd\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0ATP\u91ca\u653e\u548c\u560c\u5464\u4fe1\u53f7\u4e5f\u53c2\u4e0eT\u7ec6\u80de\u5411\u6297\u539f\u9012\u5448\u7ec6\u80de\u7684\u8fc1\u79fb\uff0c\u5e76\u5bf9\u5176\u4e2d\u7684\u673a\u5236\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u76f8\u5173\u7ed3\u679c\u53d1\u8868\u5728\u56fd\u9645\u5b66\u672f\u671f\u520aJCI\u4e0a\u3002<\/span><\/p>\n

\u8bb8\u591a\u8d8b\u5316\u56e0\u5b50\u548c\u5b83\u4eec\u7684\u53d7\u4f53\u90fd\u80fd\u591f\u8c03\u8282T\u7ec6\u80de\u5411\u9776\u7ec4\u7ec7\u7684\u8fc1\u79fb\uff0cSDF-1\u03b1\u662f\u5176\u4e2d\u4e00\u4e2a\u8d8b\u5316\u56e0\u5b50\uff0c\u80fd\u591f\u4e0e\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53CXCR4\u7ed3\u5408\u4fc3\u8fdbCD4+T\u7ec6\u80de\u5411\u6b21\u7ea7\u6dcb\u5df4\u5668\u5b98\u7684\u5f52\u5de2\uff0c\u8c03\u8282\u6dcb\u5df4\u7ed3\u5185\u7684\u7ec6\u80de\u8fc1\u79fb\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u8d8b\u5316\u56e0\u5b50SDF-1\u03b1\u80fd\u591f\u89e6\u53d1\u7ebf\u7c92\u4f53ATP\u5408\u6210\uff0cATP\u5feb\u901f\u91ca\u653e\u4ee5\u53ca\u589e\u5f3a\u4ebaCD4+T\u7ec6\u80de\u7684\u8fc1\u79fb\u80fd\u529b\u3002\u8be5\u8fc7\u7a0b\u4f9d\u8d56pannexin-1 ATP\u91ca\u653e\u901a\u9053\u548c\u5bf9P2X4\u53d7\u4f53\u7684\u81ea\u5206\u6ccc\u523a\u6fc0\uff0c\u800c\u91ca\u653e\u5230\u80de\u5916\u7684ATP\u548c\u560c\u5464\u4fe1\u53f7\u9014\u5f84\u5728\u514d\u75ab\u548c\u708e\u75c7\u8c03\u8282\u65b9\u9762\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002<\/span><\/p>\n

\u30106\u3011<\/span>Nature\uff1a\u9707\u60ca\uff01\u80bf\u7624\u4e2d\u5927\u91cf\u5730\u5b58\u5728\u4e0e\u764c\u75c7\u65e0\u5173\u7684\u65c1\u89c2\u8005CD8+ T\u7ec6\u80de<\/span><\/p>\n

doi\uff1a10.1038\/s41586-018-0130-2<\/strong><\/span><\/p>\n

\u6307\u5bfc\u60a3\u8005\u4ea7\u751f\u62b5\u6297\u764c\u7ec6\u80de\u7684\u514d\u75ab\u53cd\u5e94\u5728\u6cbb\u7597\u5bf9\u5e38\u89c4\u7597\u6cd5\u4e0d\u654f\u611f\u7684\u80bf\u7624\u65b9\u9762\u8868\u73b0\u51fa\u5de8\u5927\u7684\u5e0c\u671b\u3002\u4e0d\u5e78\u7684\u662f\uff0c\u8fd9\u7c7b\u65b9\u6cd5\u5728\u5927\u591a\u6570\u60a3\u8005\u4e2d\u4e0d\u8d77\u4f5c\u7528\u3002\u63d0\u9ad8\u5b83\u4eec\u7684\u7597\u6548\u7684\u52aa\u529b\u96c6\u4e2d\u4e8e\u7ec4\u5408\u7597\u6cd5\u548c\u9884\u6d4b\u53cd\u5e94\u6027\u548c\u62b5\u6297\u6027\u7684<\/span>\u751f\u7269\u6807\u5fd7\u7269<\/span>\uff0c\u4ee5\u53ca\u8fdb\u4e00\u6b65\u7406\u89e3<\/span>\u80bf\u7624<\/span>\u6d78\u6da6\u6027\u514d\u75ab\u7ec6\u80de\u7684\u6297\u539f\u7279\u5f02\u6027\u3002<\/span><\/p>\n

\u80bf\u7624\u4e2d\u5b58\u5728\u7684\u88ab\u79f0\u4f5c\u80bf\u7624\u6d78\u6da6\u6027\u6dcb\u5df4\u7ec6\u80de\uff08tumor-infiltrating lymphocyte\uff0c TIL\uff09\u7684\u767d\u7ec6\u80de\uff0c\u4e0e\u5927\u591a\u6570\u7c7b\u578b\u764c\u75c7\u7684\u66f4\u597d\u6cbb\u7597\u7ed3\u679c\u76f8\u5173\u8054\u3002\u8868\u8fbe\u7ec6\u80de\u8868\u9762\u7cd6\u86cb\u767dCD8\u7684TIL\u88ab\u79f0\u79f0\u4e3aCD8+ TIL\uff0c\u5b83\u4eec\u80fd\u591f\u53d1\u73b0\u764c\u7ec6\u80de\u8868\u9762\u4e0a\u7684\u80bf\u7624\u6297\u539f\u5e76\u5c06\u5b83\u4eec\u7834\u574f\u3002\u56e0\u6b64\uff0c\u8bb8\u591a\u514d\u75ab\u6cbb\u7597\u7b56\u7565\u65e8\u5728\u6fc0\u6d3b\u3001\u589e\u5f3a\u548c\u7ef4\u6301\u8fd9\u4e9b\u7ec6\u80de\u7684\u764c\u75c7\u6740\u4f24\u80fd\u529b\u3002\u7136\u800c\uff0cCD8+ TIL\u662f\u9ad8\u5ea6\u591a\u6837\u5316\u7684\u7ec6\u80de\u7fa4\u4f53\uff0c\u4e0d\u4ec5\u5728\u60a3\u8005\u4e4b\u95f4\u662f\u9ad8\u5ea6\u591a\u6837\u5316\u7684\uff0c\u800c\u4e14\u5728\u5355\u4e2a\u80bf\u7624\u5185\u4e5f\u662f\u5982\u6b64\uff0c\u6b64\u5916\u4eba\u4eec\u5bf9\u6fc0\u6d3b\u5b83\u4eec\u7684<\/span>\u80bf\u7624<\/span>\u6297\u539f\u77e5\u4e4b\u751a\u5c11\u3002<\/span><\/p>\n

\"\u591a\u7bc7\u6587\u7ae0\u805a\u7126T\u7ec6\u80de\u91cd\u78c5\u7ea7\u7814\u7a76\u6210\u679c\uff01\"<\/p>\n

\u30107\u3011<\/span>Nature\uff1a\u91cd\u5927\u7a81\u7834\uff01\u65e0\u9700\u75c5\u6bd2<\/span>\u8f7d\u4f53<\/span>\uff0c\u5229\u7528\u7535\u7a7f\u5b54\u6210\u529f\u5bf9\u4ebaT\u7ec6\u80de\u8fdb\u884cCRISPR\u57fa\u56e0\u7f16\u8f91<\/span><\/p>\n

doi\uff1a10.1038\/s41586-018-0326-5<\/strong><\/span><\/p>\n

\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u7684\u7814\u7a76\u4eba\u5458\u5728\u4e0d\u4f7f\u7528\u75c5\u6bd2\u63d2\u5165DNA\u7684\u60c5\u5f62\u4e0b\u5bf9\u4ebaT\u7ec6\u80de\uff08\u4e00\u79cd\u514d\u75ab\u7ec6\u80de\uff09\u8fdb\u884c\u91cd\u7f16\u7a0b\u3002\u8fd9\u4e00\u6210\u5c31\u5bf9\u7814\u7a76\u3001\u533b\u5b66\u548c\u4ea7\u4e1a\u4ea7\u751f\u91cd\u5927\u7684\u5f71\u54cd\u3002\u4ed6\u4eec\u671f\u5f85\u4ed6\u4eec\u7684\u65b9\u6cd5—\u4e00\u79cd\u5feb\u901f\u7684\u901a\u7528\u7684\u7ecf\u6d4e\u7684\u91c7\u7528CRISPR\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u7684\u65b9\u6cd5—\u5c06\u4f1a\u5728\u65b0\u5174\u7684\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u4e2d\u5f97\u5230\u5e7f\u6cdb\u4f7f\u7528\uff0c\u52a0\u901f\u5f00\u53d1\u51fa\u65b0\u7684\u66f4\u52a0\u5b89\u5168\u7684\u6cbb\u7597\u764c\u75c7\u3001<\/span>\u81ea\u8eab\u514d\u75ab<\/span>\u75be\u75c5\u548c\u5176\u4ed6\u75be\u75c5\uff08\u5305\u62ec\u7f55\u89c1\u7684<\/span>\u9057\u4f20<\/span>\u6027\u75be\u75c5\uff09\u7684\u7597\u6cd5\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e747\u670811\u65e5\u5728\u7ebf\u53d1\u8868\u5728Nature\u671f\u520a\u4e0a\u3002<\/span><\/p>\n

\u8fd9\u79cd\u65b0\u65b9\u6cd5\u63d0\u4f9b\u4e86\u4e00\u79cd\u5f3a\u5927\u7684\u5206\u5b50\u201c\u526a\u5207\u548c\u7c98\u8d34\u201d\u7cfb\u7edf\uff0c\u7528\u4e8e\u91cd\u5199\u4ebaT\u7ec6\u80de\u4e2d\u7684\u57fa\u56e0\u7ec4\u5e8f\u5217\u3002\u5b83\u4f9d\u8d56\u4e8e\u7535\u7a7f\u5b54\uff0c\u5373\u4e00\u79cd\u5c06\u7535\u573a\u65bd\u52a0\u5230\u7ec6\u80de\u4e0a\u4f7f\u5f97\u5b83\u4eec\u7684\u7ec6\u80de\u819c\u6682\u65f6\u5730\u66f4\u5177\u6709\u6e17\u900f\u6027\u3002\u5728\u4e00\u5e74\u5185\u8bd5\u9a8c\u4e86\u6570\u5343\u4e2a\u53d8\u91cf\u4e4b\u540e\uff0c\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u5f53\u67d0\u4e9b\u6570\u91cf\u7684T\u7ec6\u80de\u3001DNA\u548cCRISPR\u201c\u526a\u5200\u201d\u6df7\u5408\u5728\u4e00\u8d77\u7136\u540e\u66b4\u9732\u5728\u4e00\u79cd\u9002\u5f53\u7684\u7535\u573a\u4e2d\u65f6\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u5c06\u6444\u5165DNA\u548cCRISPR\u526a\u5200\uff0c\u5e76\u4e14\u7cbe\u786e\u5730\u5c06\u7279\u5b9a\u7684\u57fa\u56e0\u5e8f\u5217\u6574\u5408\u5230CRISPR\u5728\u57fa\u56e0\u7ec4\u4e2d\u7684\u9776\u5207\u5272\u4f4d\u70b9\u4e0a\u3002<\/span><\/p>\n

\u8bba\u6587\u901a\u4fe1\u4f5c\u8005\u3001\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u5fae\u751f\u7269\u5b66\u4e0e<\/span>\u514d\u75ab\u5b66<\/span>\u526f\u6559\u6388Alex Marson\u535a\u58eb\u8bf4\uff0c\u201c\u8fd9\u662f\u4e00\u79cd\u5feb\u901f\u800c\u53c8\u7075\u6d3b\u7684\u65b9\u6cd5\uff0c\u53ef\u7528\u4e8e\u6539\u53d8\u3001\u5f3a\u5316\u548c\u91cd\u7f16\u7a0bT\u7ec6\u80de\uff0c\u8fd9\u6837\u6211\u4eec\u5c31\u80fd\u591f\u7ed9\u5b83\u4eec\u63d0\u4f9b\u6211\u4eec\u60f3\u8981\u7684\u7279\u5f02\u6027\u6765\u6e05\u9664\u764c\u75c7\u3001\u8bc6\u522b\u611f\u67d3\u6216\u8005\u6291\u5236<\/span>\u81ea\u8eab\u514d\u75ab<\/span>\u6027\u75be\u75c5\u4e2d\u89c2\u5bdf\u5230\u7684\u8fc7\u5ea6\u514d\u75ab\u53cd\u5e94\u3002\u201d<\/span><\/p>\n

\u30108\u3011<\/span>Cell Metabolism\uff1a\u5173\u6ce8\u80bf\u7624\u4ee3\u8c22\uff01\u79d1\u5b66\u5bb6\u63ed\u793a\u8fc7\u7ee7\u6027T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u4ea7\u751f\u6297\u764c\u7597\u6548\u7684\u673a\u5236<\/span><\/p>\n

doi\uff1a10.1016\/j.cmet.2018.05.012<\/strong><\/span><\/p>\n

\u8fc7\u53bb\u6570\u5341\u5e74\u4e2d\u79d1\u5b66\u5bb6\u4eec\u5bf9\u80bf\u7624\u6291\u5236T\u7ec6\u80de\u4ee3\u8c22\u7684\u60c5\u51b5\u5df2\u7ecf\u7814\u7a76\u5f97\u5f88\u900f\u5f7b\u4e86\uff0c\u4f46\u662f\u514d\u75ab\u7597\u6cd5\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u4ee3\u8c22\u6c34\u5e73\u5f71\u54cd\u5374\u9c9c\u6709\u7814\u7a76\u3002\u4e3a\u6b64\u6765\u81ea\u5965\u53e4\u65af\u5854\u5927\u5b66\u7b49\u5355\u4f4d\u7684\u79d1\u5b66\u5bb6\u4eec\u8fd1\u65e5\u5f00\u53d1\u4e86\u4e00\u79cdCD4+T\u7ec6\u80de\u8fc7\u7ee7\u7597\u6cd5\uff0c\u53ef\u4ee5\u6cbb\u6108\u79fb\u690d\u6709\u7ed3\u76f4\u80a0\u764c\u7684\u5c0f\u9f20\u3002\u901a\u8fc7\u5bf9\u80bf\u7624\u8fdb\u884c\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u8fc7\u7ee7\u6027T\u7ec6\u80de\u7597\u6cd5\u53ef\u4ee5\u663e\u8457\u6539\u53d8\u80bf\u7624\u7684\u4ee3\u8c22\u60c5\u51b5\uff0c\u5bfc\u81f4<\/span>\u80bf\u7624<\/span>\u7ec6\u80de\u4e2d\u8c37\u80f1\u7518\u80bd\u88ab\u6e05\u9664\u3001\u6d3b\u6027\u6c27\uff08ROS\uff09\u6c34\u5e73\u5347\u9ad8\uff0c\u76f8\u5173\u7814\u7a76\u4e8e\u8fd1\u65e5\u53d1\u8868\u5728\u300aCell Metabolism \u300b\u4e0a\u3002<\/span><\/p>\n

\u901a\u8fc7\u8fdb\u4e00\u6b65\u5206\u6790\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0T\u7ec6\u80de\u6765\u6e90\u7684\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u03b1\uff08tumor necrosis factor alpha\uff0cTNF-\u03b1\uff09\u53ef\u4ee5\u4e0e\u5316\u7597\u534f\u540c\u4f5c\u7528\uff0c\u4ee5\u4e00\u79cd\u4f9d\u8d56\u4e8e\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\u78f7\u9178\uff08nicotinamide adenine dinucleotide phosphate hydrogen\uff0cNADPH\uff09\u6c27\u5316\u9176\u7684\u65b9\u5f0f\u52a0\u5267\u6c27\u5316\u5e94\u6fc0\u548c\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002\u800c\u901a\u8fc7\u6291\u5236<\/span>\u80bf\u7624<\/span>\u7ec6\u80de\u4e2d\u7684TNF-\u03b1\u4fe1\u53f7\u6216\u8005\u6e05\u9664ROS\u6765\u524a\u5f31\u6c27\u5316\u5e94\u6fc0\u6c34\u5e73\u53ef\u4ee5\u524a\u5f31\u8fc7\u7ee7\u6027T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u7597\u6548\uff0c\u53cd\u8fc7\u6765\u5982\u679c\u5316\u7597\u540e\u63d0\u4f9b\u4fc3\u6c27\u5316\u5242\u53ef\u4ee5\u90e8\u5206\u6062\u590d\u8fc7\u7ee7\u6027T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6297\u764c\u80fd\u529b\u3002<\/span><\/p>\n

\"\u591a\u7bc7\u6587\u7ae0\u805a\u7126T\u7ec6\u80de\u91cd\u78c5\u7ea7\u7814\u7a76\u6210\u679c\uff01\"<\/p>\n

\u30109\u3011<\/span>Science\uff1a\u63ed\u793a\u5c40\u90e8\u7684\u7ec6\u80de\u96c6\u4f53\u884c\u4e3a\u8bf1\u5bfcT\u7ec6\u80de\u8bb0\u5fc6\u673a\u5236<\/span><\/p>\n

doi\uff1a10.1126\/science.aaj1853<\/strong><\/span><\/p>\n

\u7ec6\u80de\u547d\u8fd0\u51b3\u5b9a\u5728\u810a\u690e\u52a8\u7269\u514d\u75ab\u7cfb\u7edf\u7684\u8fd0\u4f5c\u4e2d\u8d77\u7740\u6838\u5fc3\u4f5c\u7528\u3002\u5efa\u7acb\u6709\u6548\u7684\u83b7\u5f97\u6027\u514d\u75ab\u53cd\u5e94\u53d6\u51b3\u4e8e\u521d\u59cbT\u7ec6\u80de\uff08na\uff1fve T cell\uff09\u5728\u8bc6\u522b\u540c\u6e90\u6297\u539f\uff08cognate antigen\uff09\u540e\u5206\u5316\u6210\u5404\u79cd\u7c7b\u578b\u7684\u6548\u5e94T\u7ec6\u80de\uff08effector T cell\uff09\u548c\u8bb0\u5fc6T\u7ec6\u80de\uff08memory T cell\uff09\u4ee5\u53ca\u8fd9\u4e9b\u7ec6\u80de\u7fa4\u4f53\u4e4b\u95f4\u7684\u9002\u5f53\u5e73\u8861\u3002\u8bb8\u591a\u7814\u7a76\u5df2\u8868\u660e\u5f53\u66f4\u591a\u7684T\u7ec6\u80de\u53c2\u4e0e\u8fd9\u79cd\u514d\u75ab\u53cd\u5e94\u65f6\uff0c\u6548\u5e94T\u7ec6\u80de\u548c\u4e2d\u67a2\u8bb0\u5fc6T\u7ec6\u80de\uff08central memory T cell\uff09\u4e4b\u95f4\u7684\u5e73\u8861\u5411\u6709\u5229\u4e8e\u4e2d\u67a2\u8bb0\u5fc6T\u7ec6\u80de\u7684\u65b9\u5411\u8f6c\u53d8\u3002\u8fd9\u79cd\u89c2\u5bdf\u7ed3\u679c\u5177\u6709\u7fa4\u4f53\u611f\u5e94\uff08quorum sensing\uff09—\u7ec6\u80de\u5bf9\u5b83\u4eec\u7684\u7fa4\u4f53\u5bc6\u5ea6\u4f5c\u51fa\u53cd\u5e94\u7684\u80fd\u529b—\u7684\u7279\u5f81\u3002\u7136\u800c\uff0c\u9a71\u52a8T\u7ec6\u80de\u4e2d\u7684\u8fd9\u79cd\u884c\u4e3a\u7684\u673a\u5236\u4ecd\u7136\u662f\u96be\u4ee5\u6349\u6478\u7684\u3002<\/span><\/p>\n

\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u4ee5\u8272\u5217\u9b4f\u5179\u66fc\u79d1\u5b66\u7814\u7a76\u6240\u548c\u82f1\u56fd\u4f26\u6566\u5927\u5b66\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u5728\u4f53\u5185\u548c\u4f53\u5916\u89c2\u5bdf\u5230\u5728\u8f83\u9ad8\u7684\u7ec6\u80de\u5bc6\u5ea6\u4e0b\uff0c\u7956\u7ec6\u80de\u4e2d\u67a2\u8bb0\u5fc6T\u7ec6\u80de\uff08progenitor central memory T cell\uff0c pTCM\uff09\u7684\u5206\u5316\u589e\u52a0\u4e86\u3002\u7136\u800c\uff0c\u6d3b\u5316\u7684T\u7ec6\u80de\u5feb\u901f\u5f62\u6210\u5bc6\u96c6\u52a8\u6001\u7ec6\u80de\u7c07\uff08dense dynamic cluster\uff09\uff0c\u4ece\u800c\u5f88\u96be\u533a\u5206\u8fd9\u79cd\u5bc6\u96c6\u52a8\u6001\u7ec6\u80de\u7c07\u4e2d\u7684\u5c40\u90e8\u76f8\u4e92\u4f5c\u7528\u548c\u901a\u8fc7\u53ef\u6eb6\u6027\u56e0\u5b50\u8fdb\u884c\u7684\u5168\u5c40\u957f\u7a0b\u76f8\u4e92\u4f5c\u7528\u5f00\u6765\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u79cd\u56f0\u96be\uff0c\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u6d3b\u7ec6\u80de\u6210\u50cf\u6765\u8ffd\u8e2a\u5fae\u5b54\u9635\u5217\u4e2d\u57f9\u517b\u7684\u7ec6\u80de\u589e\u6b96\u548c\u5206\u5316\u3002<\/span><\/p>\n

\u301010\u3011<\/span>Science\u5b50\u520a\uff1a\u91cd\u5927\u53d1\u73b0\uff01\u8d85\u7ea7T\u7ec6\u80de\u53d7\u4f53\u6709\u52a9\u6740\u6b7b\u906d\u53d7HIV\u611f\u67d3\u7684\u7ec6\u80de<\/span><\/p>\n

doi\uff1a10.1126\/sciimmunol.aat0687<\/strong><\/span><\/p>\n

\u6839\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\uff08WHO\uff09\u7684\u7edf\u8ba1\u6570\u636e\uff0c2016\u5e74\u67093670\u4e07\u4eba\u611f\u67d3\u4e0aHIV\uff0c100\u4e07\u4eba\u6b7b\u4e8eHIV\u611f\u67d3\u5bfc\u81f4\u7684\u827e\u6ecb\u75c5\uff08AIDS\uff09\uff0c1950\u4e07\u611f\u67d3\u4e0aHIV\u7684\u4eba\u63a5\u53d7\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u836f\u7269\u6cbb\u7597\uff08ART\uff09\u3002<\/span><\/p>\n

\u867d\u7136\u5bf9HIV\u611f\u67d3\u7684\u6cbb\u7597\u610f\u5473\u7740\u8fd9\u79cd\u75be\u75c5\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4e0d\u518d\u662f\u81f4\u547d\u6027\u7684\uff0c\u4f46\u662f\u4e16\u754c\u4ecd\u7f3a\u4e4f\u80fd\u591f\u6839\u9664\u5168\u7403\u8303\u56f4\u5185\u5177\u6709\u4e0d\u540c<\/span>\u9057\u4f20<\/span>\u80cc\u666f\u7684\u4eba\u7fa4\u4f53\u5185\u7684HIV\u75c5\u6bd2\u7684\u7597\u6cd5\u3002<\/span><\/p>\n

\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u6fb3\u5927\u5229\u4e9a\u83ab\u7eb3\u4ec0\u5927\u5b66\u548c\u6cd5\u56fd\u5df4\u65af\u5fb7\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u514d\u75ab\u7ec6\u80de\u8868\u9762\u4e0a\u7684\u4e00\u7ec4\u72ec\u7279\u7684\u201c\u8d85\u7ea7\u201d\u53d7\u4f53\u80fd\u591f\u6740\u6b7b<\/span>\u9057\u4f20<\/span>\u591a\u6837\u6027\u7684\u4eba\u7fa4\u4f53\u5185\u7684HIV\uff0c\u8fd9\u5c31\u4f7f\u5f97\u5b83\u4eec\u79f0\u4e3a\u514d\u75ab\u7597\u6cd5\u7684\u4e00\u79cd\u6f5c\u5728\u5019\u9009\u7269\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u57282018\u5e746\u67088\u65e5\u7684Science Immunology\u671f\u520a\u4e0a\u3002<\/span><\/p>\n

\u8f6c\u8f7d\u81ea\uff1a\u751f\u7269\u8c37   \u5982\u6709\u4fb5\u6743\u8bf7\u8054\u7cfb\u5220\u9664<\/span><\/p>\n

\"\u591a\u7bc7\u6587\u7ae0\u805a\u7126T\u7ec6\u80de\u91cd\u78c5\u7ea7\u7814\u7a76\u6210\u679c\uff01\"
<\/p>\n

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