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\n

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\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a<\/p>\n

                            
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\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a<\/p>\n


<\/span><\/p>\n

\u5176\u4e2d<\/span>Tg<\/span>\u3001<\/span>Tg1<\/sub><\/span>\u548c<\/span>Tg2<\/sub><\/span>\u5206\u522b\u662f\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u6df7\u5408\u7269\u3001\u975e\u6676\u6001\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u7684\u73bb\u7483\u5316\u8f6c\u53d8\u6e29\u5ea6\uff1b<\/span>W1<\/sub><\/span>\u548c<\/span>W2<\/sub><\/span>\u5206\u522b\u662f\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u7684\u91cd\u91cf\u5206\u6570\uff0c<\/span>KG<\/sub><\/span>\u662f\u4e00\u4e2a\u5e38\u6570\uff0c\u5176\u503c\u53d6\u51b3\u4e8e\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u6c34\u5e73\uff0c\u53ef\u4ee5\u7528\u516c\u5f0f\uff08\u65b9\u7a0b<\/span>4)<\/span>\u8ba1\u7b97\u5f97\u5230\uff1a<\/span><\/span><\/p>\n


<\/p>\n

\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a<\/p>\n

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\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a<\/p>\n

\u56fe<\/span>6<\/span><\/span><\/strong><\/span>\u7531<\/span>Gordon-Taylor<\/span>\u65b9\u7a0b\u9884\u6d4b\u7684\u504f\u79bb\u7406\u60f3\u884c\u4e3a\uff1b<\/span>D<\/span>\u4ee3\u8868\u836f\u7269\uff0c<\/span>P<\/span>\u4ee3\u8868\u9ad8\u5206\u5b50\u6750\u6599\uff1b\u56fe\u8868\u5e76\u672a\u6309\u6bd4\u4f8b\u7f29\u653e\u3002<\/span><\/span><\/p>\n

\u56fe<\/span>6<\/span>\u6240\u793a\u3002\u8fd9\u662f\u7531\u4e8e\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u7684\u975e\u7406\u60f3\u6df7\u5408\u5bfc\u81f4\u7684\u4f53\u79ef\u975e\u52a0\u548c\u6027\u5f15\u8d77\u7684<\/span>109<\/span><\/sup>\u3002<\/span><\/span><\/p>\n

\u5f53\u836f\u7269\u5206\u6563\u5728\u9ad8\u5206\u5b50\u6750\u6599\u57fa\u8d28\u4e2d\u65f6\uff0c\u540c\u6838\u548c\u5f02\u6838\u4e4b\u95f4\u5c06\u53d1\u751f\u76f8\u4e92\u4f5c\u7528\u3002\u8fd9\u4e9b\u76f8\u4e92\u4f5c\u7528\u7684\u7ed3\u679c\u53ef\u4ee5\u8868\u793a\u5982\u4e0b\uff1a<\/span><\/p>\n

\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a<\/p>\n

\u5176\u4e2d<\/span>D<\/span>\u548c<\/span>P<\/span>\u5206\u522b\u4ee3\u8868\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u3002\u8fd9\u4e9b\u76f8\u4e92\u4f5c\u7528\u7684\u76f8\u5bf9\u5f3a\u5ea6\u51b3\u5b9a\u4e86<\/span>ASDs<\/span>\u7684\u6700\u7ec8\u4f53\u79ef\u3002\u7b2c\u4e00\u79cd\u60c5\u51b5\uff0c\u540c\u6838\u95f4\u4f5c\u7528\u5f3a\u4e8e\u5f02\u6838\u3002\u56e0\u6b64\uff0c\u5f53\u5f62\u6210\u56fa\u4f53\u5206\u6563\u4f53\u65f6\uff0c\u4f53\u79ef\u4f1a\u51fa\u73b0\u51c0\u6536\u7f29\u3002\u7b2c\u4e8c\u79cd\u60c5\u51b5\u663e\u793a\u66f4\u5f3a\u7684\u5f02\u6838\u95f4\u4f5c\u7528\u5f15\u53d1\u4e86\u7cfb\u7edf\u7684\u51c0\u81a8\u80c0\u3002\u7b2c\u4e09\u79cd\u60c5\u51b5\u662f\u4f53\u79ef\u6ca1\u6709\u51c0\u589e\u51cf\u7684\u7406\u60f3\u60c5\u51b5\uff0c\u4f53\u73b0\u4e86\u7406\u60f3\u7684\u4f53\u79ef\u52a0\u548c\u6027\u3002\u7406\u60f3\u60c5\u51b5\u4e0b\uff0c\u836f\u7269\u4e0e\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u5e94\u5b8c\u5168\u6df7\u6eb6\uff0c\u836f\u7269\u5e94\u5747\u5300\u5206\u6563\u5728\u9ad8\u5206\u5b50\u6750\u6599\u8f7d\u4f53\u4e2d\u3002\u7136\u800c\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u7684\u6df7\u5408\u7269\u65e0\u6cd5\u5b9e\u73b0\u7406\u60f3\u6df7\u5408\uff0c\u8fd9\u79cd\u975e\u7406\u60f3\u6df7\u5408\u72b6\u6001\u5bfc\u81f4\u4e86<\/span>Tg<\/span>\u7684\u5b9e\u9a8c\u503c\u548c\u7406\u8bba\u503c\u4e4b\u95f4\u51fa\u73b0\u4e86\u504f\u5dee\u3002\u901a\u5e38\u4f18\u5148\u9009\u62e9\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u66f4\u5f3a\u7684\u7ec4\u5408\uff0c\u4ea7\u751f\u6709\u5229\u7684\u6df7\u5408\u653e\u70ed\u6765\u589e\u52a0\u6784\u578b\u71b5<\/span>110<\/span><\/sup>\u3002<\/span>Crowley<\/span>\u7b49\u4eba<\/span>111<\/span><\/sup>\u7814\u7a76\u4e86\u975e\u7406\u60f3\u6027\u6df7\u5408\uff0c\u5e76\u6307\u51fa\u8fd9\u4e9b\u504f\u79bb\u9884\u6d4b\u7684\u539f\u56e0\u662f\u5f02\u5206\u5b50\u4e0e\u540c\u5206\u5b50\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u76f8\u5bf9\u7a0b\u5ea6\u5dee\u5f02\u3002\u8fd9\u4e0e<\/span>Fule<\/span>\u7b49\u4eba<\/span>112<\/span><\/sup>\u7684\u7814\u7a76\u7ed3\u8bba\u4e00\u81f4\uff0c\u4ed6\u4eec\u6307\u51fa\uff1a\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u7684\u5206\u5b50\u95f4\u76f8\u4e92\u4f5c\u7528\u5728\u975e\u7406\u60f3\u6df7\u5408\u4e2d\u626e\u6f14\u7740\u91cd\u8981\u89d2\u8272\u3002<\/span><\/span><\/p>\n

\u5206\u5b50\u95f4\u76f8\u4e92\u4f5c\u7528<\/span><\/strong><\/p>\n

\u836f\u7269\u5206\u5b50\u53ef\u4ee5\u901a\u8fc7\u8bf8\u5982\u6c22\u952e\u3001\u8303\u5fb7\u534e\u529b\u3001\u9759\u7535\u529b\u3001\u79bb\u5b50\u952e\u6216\u758f\u6c34\u6027\u51e0\u79cd\u5f31\u4f5c\u7528\u529b\u4e0e\u9ad8\u5206\u5b50\u6750\u6599\u5206\u5b50\u4e4b\u95f4\u53d1\u751f\u76f8\u4e92\u4f5c\u7528<\/span>113<\/span><\/sup>\u3002\u8fd9\u4e9b\u5206\u5b50\u95f4\u7684\u5316\u5b66\u952e\u9650\u5236\u4e86\u836f\u7269\u5206\u5b50\u5728\u9ad8\u5206\u5b50\u6750\u6599\u57fa\u8d28\u4e2d\u7684\u6d41\u52a8\u6027\uff0c\u4e3a\u4f53\u7cfb\u7a33\u5b9a\u6027\u63d0\u4f9b\u4fdd\u969c\u3002<\/span>Khougaz<\/span>\u7b49\u4eba<\/span>114<\/span><\/sup>\u63cf\u8ff0\u4e86\u7279\u5b9a\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5728\u7a33\u5b9a\u56fa\u4f53\u5206\u6563\u4f53\u4e2d\u7684\u4f5c\u7528\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u5f53\u975e\u6676\u6001\u836f\u7269<\/span>MK-0591<\/span>\u5206\u6563\u5728\u8bf8\u5982<\/span>PVP K-12<\/span>\u6216<\/span>PVP\/<\/span>\u918b\u9178\u4e59\u70ef\u916f\u7b49\u4e0d\u540c\u9ad8\u5206\u5b50\u6750\u6599\u4e2d\u65f6\uff0c<\/span>ASD<\/span>\u7684\u6700\u7ec8<\/span>Tg<\/span>\u503c\u4f4e\u4e8e\u975e\u6676\u6001\u836f\u7269\u3002\u800c\u4e14\u50a8\u5b58\u4e00\u5e74\u540e\u56fa\u4f53\u5206\u6563\u4f53\u4ecd\u4fdd\u6301\u7a33\u5b9a\u3002\u8fd9\u8868\u660e\u6297\u5851\u5316\u4f5c\u7528\u5e76\u4e0d\u662f\u5bfc\u81f4\u8131\u73bb\u901f\u7387\u964d\u4f4e\u7684\u552f\u4e00\u56e0\u7d20\u3002\u7ea2\u5916\u5149\u8c31\uff08<\/span>IR<\/span>\uff09\u8bc1\u5b9e\u4e86<\/span>PVP<\/span>\u4e2d\u7684\u7fb0\u57fa\u548c<\/span>MK-0591<\/span>\u4e2d\u7684\u7fa7\u57fa\uff08<\/span>COO-Na+<\/sup><\/span>\uff09\u4e4b\u95f4\u5b58\u5728\u79bb\u5b50\u5076\u6781\u529b\u4f5c\u7528\uff0c\u8868\u660e\u5f31\u5206\u5b50\u95f4\u4f5c\u7528\u529b\u5bf9\u7a33\u5b9a\u9ad8\u5206\u5b50\u6750\u6599\u57fa\u8d28\u4e2d\u7684\u975e\u6676\u6001\u836f\u7269\u4e5f\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002<\/span>Meng<\/span>\u7b49\u4eba<\/span>115<\/span><\/sup>\u8fdb\u884c\u4e86\u53e6\u4e00\u9879\u6709\u8da3\u7684\u7814\u7a76\uff0c\u5176\u4e2d\u5f3a\u8c03\u4e86\u5316\u5b66\u952e\u5f62\u6210\u6216\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u5bf9\u4ee5\u975e\u6676\u6001\u59dc\u9ec4\u7d20\u4f5c\u4e3a\u6a21\u578b\u836f\u7269\u7684\u7a33\u5b9a\u6027\u4ea7\u751f\u7684\u91cd\u8981\u5f71\u54cd\u3002\u4ed6\u4eec\u5c1d\u8bd5\u4e86<\/span>PVP K90<\/span>\u3001<\/span>Eudragit Epo\u00ae<\/sup><\/span>\u3001<\/span>HPMC<\/span>\u548c<\/span>PEG 8000<\/span>\u7b49<\/span>4<\/span>\u79cd\u4e0d\u540c\u9ad8\u5206\u5b50\u6750\u6599\uff0c\u901a\u8fc7\u5f62\u6210\u7a33\u5b9a\u7684\u5316\u5b66\u952e\u4e0e\u6a21\u578b\u836f\u7269\u59dc\u9ec4\u7d20\u4e4b\u95f4\u53d1\u751f\u76f8\u4e92\u4f5c\u7528\u3002\u5728\u7a33\u5b9a\u6027\u7814\u7a76\u4e2d\uff0c\u4ed6\u4eec\u53d1\u73b0<\/span>Eudragit\u00ae<\/sup><\/span>\u662f<\/span>4<\/span>\u79cd\u9ad8\u5206\u5b50\u6750\u6599\u4e2d\u552f\u4e00\u80fd\u5c06\u59dc\u9ec4\u7d20\u7a33\u5b9a\u5728\u6df7\u6eb6\u6027\u6781\u9650\u7684\uff0c\u5e76\u4e14\u6539\u5584\u4e86\u5176\u6eb6\u89e3\u6027\u80fd\u3002\u5229\u7528<\/span>IR<\/span>\u5149\u8c31\u548c\u62c9\u66fc\u5149\u8c31\u89e3\u6790\u4e86\u59dc\u9ec4\u7d20\u548c<\/span>Eudragit\u00ae<\/sup><\/span>\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u5f97\u51fa\u7684\u7ed3\u8bba\u662f\uff0c\u836f\u7269\u4e0e\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u4e00\u5b9a\u7a0b\u5ea6\u7684\u76f8\u4e92\u4f5c\u7528\u5bf9\u4e8e\u6210\u529f\u5236\u5907<\/span>ASDs<\/span>\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/span><\/span><\/p>\n

Miyazaki<\/span>\u7b49\u4eba<\/span>116<\/span><\/sup>\u7684\u4e00\u9879\u7814\u7a76\uff0c\u8bc1\u660e\u4e86\u7acb\u4f53\u9009\u62e9\u6027\u76f8\u4e92\u4f5c\u7528\u529b\u5728\u5229\u7528\u7194\u878d\u6dec\u706b\u6cd5\u5236\u5907\u7684\u975e\u6676\u6001\u5c3c\u7fa4\u5730\u5e73\uff08<\/span>NTR<\/span>\uff09\u7a33\u5b9a\u6027\u4e2d\u7684\u5f71\u54cd\u3002\u4ed6\u4eec\u4ee5<\/span>PVP<\/span>\u3001<\/span>HPMC<\/span>\u548c<\/span>HPMC-<\/span>\u82ef\u4e8c\u7532\u9178\u916f\uff08<\/span>HPMCP<\/span>\uff09\u4e3a\u624b\u6027\u9ad8\u5206\u5b50\u6a21\u578b\u6750\u6599\uff0c\u9610\u660e\u4e86\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u7684\u7acb\u4f53\u9009\u62e9\u6027\u76f8\u4e92\u4f5c\u7528\u5bf9<\/span>ASD<\/span>\u7ed3\u6676\u901f\u7387\u7684\u5f71\u54cd\u3002\u5982\u56fe<\/span>7<\/span>\u6240\u793a\uff0c\u624b\u6027\u9ad8\u5206\u5b50\u6750\u6599<\/span>HPMC<\/span>\u548c<\/span>HPMCP<\/span>\u5728<\/span>50<\/span>\u2103<\/span>-70<\/span>\u2103\u65f6\u5bf9<\/span>(+)-NTR<\/span>\u7684\u7ed3\u6676\u6291\u5236\u4f5c\u7528\u6bd4<\/span>(-)-NTR<\/span>\u66f4\u52a0\u660e\u663e\u3002\u53e6\u4e00\u65b9\u9762\uff0c<\/span>PVP<\/span>\u4e0d\u4f18\u5148\u4e0e\u4efb\u4f55\u5bf9\u6620\u4f53\u53d1\u751f\u76f8\u4e92\u4f5c\u7528\uff0c\u56e0\u6b64\u5bf9<\/span>NTR<\/span>\u7684\u7ed3\u6676\u8fc7\u7a0b\u6ca1\u6709\u5f71\u54cd\u3002\u8fd9\u79cd\u7ed3\u6676\u8fc7\u7a0b\u6216\u7269\u7406\u7a33\u5b9a\u6027\u7684\u5dee\u5f02\u53ef\u5f52\u56e0\u4e8e\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u7684\u76f8\u4e92\u7acb\u4f53\u9009\u62e9\u6027\u4f5c\u7528\u3002\u4f46\u7531\u4e8e\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u8f83\u5f31\uff0c\u5728<\/span>25<\/span>\u2103\u65f6\u5bf9<\/span>ASD<\/span>\u7684\u7269\u7406\u7a33\u5b9a\u6027\u5f71\u54cd\u5f88\u5c0f\u3002<\/span><\/span><\/p>\n

Shah<\/span>\u7b49\u4eba\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\u4f5c\u4e3a\u6a21\u578b\u836f\u7269\uff0c\u918b\u9178\u7f9f\u4e19\u7532\u7ea4\u7ef4\u7d20\u7425\u73c0\u9178\u916f\uff08<\/span>HPMCAS<\/span>\uff09\u3001<\/span>HPMCP<\/span>\u548c<\/span>Eudragit\u00ae <\/sup>L<\/span>\u4f5c\u4e3a\u6a21\u578b\u9ad8\u5206\u5b50\u6750\u6599\uff0c\u91c7\u7528\u6eb6\u5242\u63a7\u5236\u5171\u6c89\u6dc0\u6cd5\u5236\u5907\u4e86\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff0c\u8fdb\u4e00\u6b65\u5f3a\u8c03\u4e86\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u5bf9\u7ef4\u6301\u836f\u7269\u7a33\u5b9a\u6027\u3001\u63d0\u9ad8\u836f\u7269\u6eb6\u89e3\u5ea6\u548c\u8fc7\u9971\u548c\u7a0b\u5ea6\u7684\u8d21\u732e<\/span>117<\/span><\/sup>\u3002\u4ed6\u4eec\u8bc1\u660e\uff0c\u4e0e\u5176\u4ed6\u9ad8\u5206\u5b50\u6750\u6599\u76f8\u6bd4\uff0c<\/span>HPMCAS<\/span>\u53ef\u4ee5\u901a\u8fc7<\/span>PASD<\/span>\u4e2d\u7684\u6c22\u952e\u53ca\u5176\u4ed6\u8f83\u5f31\u7684\u76f8\u4e92\u4f5c\u7528\u529b\u4e0e\u7ef4\u83ab\u975e\u5c3c\u5b98\u80fd\u56e2\u53d1\u751f\u6709\u6548\u5730\u4f5c\u7528\u3002\u8fd9\u5c06\u4f7f\u5176\u5177\u6709\u66f4\u9ad8\u7684\u7a33\u5b9a\u6027\u5e76\u7ef4\u6301\u5728\u66f4\u9ad8\u6c34\u5e73\u7684\u8fc7\u9971\u548c\u7a0b\u5ea6\u4e0a\u3002\u4e8b\u5b9e\u4e0a\uff0c<\/span>Maniruzzaman<\/span>\u7b49\u4eba<\/span>118<\/span><\/sup>\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u4ed6\u4eec\u5728\u4f7f\u7528\u70ed\u7194\u6324\u51fa\u5de5\u827a\u5236\u5907<\/span>PASDs<\/span>\u4e2d\u7684\u7a33\u5b9a\u4f5c\u7528\u3002\u7814\u7a76\u8868\u660e\uff0c<\/span>X<\/span>\u5c04\u7ebf\u5149\u7535\u5b50\u80fd\u8c31\u548c\u5206\u5b50\u6a21\u62df\u56fe\uff08\u89c1\u56fe<\/span>8<\/span>\uff09\u8bc1\u5b9e\u4e86\u9ad8\u5206\u5b50\u6750\u6599\u4e2d\u7684\u7fa7\u57fa\u4e0e<\/span>API<\/span>\u4e2d\u7684\u6c28\u57fa\u5b98\u80fd\u56e2\u4e4b\u95f4\u5b58\u5728\u6c22\u952e\u548c\u5206\u5b50\u95f4\u79bb\u5b50\u952e\u3002\u4ed6\u4eec\u8fd8\u63d0\u51fa\u5206\u5b50\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u5927\u5c0f\u53d6\u51b3\u4e8e\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u7684\u6bd4\u4f8b\u548c\u6df7\u6eb6\u6027\u3002<\/span><\/span><\/p>\n

\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a<\/p>\n

\u56fe<\/span>7<\/span><\/strong>  60\u2103\u4e0b<\/span>,\u5728\u5c3c\u7fa4\u5730\u5e73\u5bf9\u6620\u4f53<\/span>(a)\u53ca\u5176\u5bf9\u6620\u4f53\u5206\u522b\u5728<\/span>10%PVP(b)\u3001<\/span>10%HPMC(c)\u548c<\/span>10%HPMCP(d)\u65e0\u5b9a\u5f62\u56fa\u4f53\u5206\u6563\u4f53\u4e2d\u7684\u7ed3\u6676\u901f\u7387<\/span>;\u7ecf<\/span>Miyazaki116<\/sup>\u8bb8\u53ef\u8f6c\u8f7d\u3002\u7ebf\u4ee3\u8868<\/span>Avrami\u6a21\u578b\u7684\u6700\u4f73\u5339\u914d\u66f2\u7ebf<\/span>;\u95ed\u5408\u7b26\u53f7\u4ee3\u8868<\/span>(+)-\u5c3c\u7fa4\u5730\u5e73<\/span>(NTR),\u5f00\u653e\u7b26\u53f7\u4ee3\u8868<\/span>(-)-NTR\u5bf9\u6620\u4f53\u3002<\/span><\/span><\/p>\n

<\/span><\/strong>
<\/p>\n

\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a<\/p>\n

\u56fe<\/span>8<\/span><\/strong> \u4f7f\u7528\u9ad8\u65af<\/span>09\u8f6f\u4ef6\u7ed8\u5236\u7684\u836f\u7269<\/span>\/\u9ad8\u5206\u5b50\u80fd\u91cf\u4f18\u5316\u540e\u7684\u5206\u5b50\u6a21\u578b<\/span>B3LYP 6-31G\uff1b<\/span>PRP\u4ee3\u8868\u76d0\u9178\u666e\u8418\u6d1b\u5c14\uff0c<\/span>L100\u4ee3\u8868<\/span>Eudragit L100\uff0c<\/span> L100-55\u4ee3\u8868<\/span>Eudragit L100-55\uff1b<\/span><\/span><\/p>\n

\u8be5\u8f6c\u8f7d\u5df2\u7ecf<\/span>Maniruzzaman\u5141\u8bb8<\/span>118<\/sup>\u3002<\/span><\/span><\/p>\n

\u964d\u4f4e\u975e\u6676\u6001\u836f\u7269\u5728<\/span>PASD\u4e2d\u7684\u5206\u5b50\u6d41\u52a8\u6027<\/span><\/span><\/strong><\/p>\n

PASD<\/span>\u4e2d\u975e\u6676\u6001\u836f\u7269\u7684\u7406\u5316\u7a33\u5b9a\u6027\u7684\u63d0\u9ad8\u53ef\u4ee5\u7528\u5206\u5b50\u6d41\u52a8\u6027\u6539\u53d8\u6765\u89e3\u91ca\u3002\u836f\u7269\u7684\u72ec\u7acb\u4e9a\u7a33\u7ed3\u6676\u72b6\u6001\u53ef\u4ee5\u8868\u73b0\u5f97\u597d\u50cf\u5b83\u4e0d\u53d7\u7a33\u5b9a\u7ed3\u6676\u5f62\u6001\u7684\u5f71\u54cd\uff0c\u76f4\u5230\u591a\u6676\u578b\u8f6c\u53d8\u53d1\u751f\u3002\u7136\u800c\uff0c\u975e\u6676\u6001\u836f\u7269\u53ef\u80fd\u4f1a\u8868\u73b0\u5f97\u597d\u50cf\u5b83\u603b\u662f\u80fd\u8bc6\u522b\u51fa\u66f4\u7a33\u5b9a\u7684\u6676\u4f53\u5f62\u6001\u7684\u5b58\u5728\uff0c\u5e76\u9010\u6e10\u4ee5\u67d0\u79cd\u65b9\u5f0f\u5411\u5b83\u884d\u5316\uff0c\u8fd9\u53ef\u4ee5\u901a\u8fc7\u5b83\u7684\u70ed\u5386\u53f2\u548c\u975e\u5e73\u8861\u7a0b\u5ea6\u6765\u9884\u6d4b\u3002\u8fd9\u5c31\u662f\u6240\u8c13\u7684\u7ed3\u6784\u5f1b\u8c6b\u73b0\u8c61<\/span>119<\/span><\/sup>\u3002\u975e\u6676\u6001\u6750\u6599\u7684\u5206\u5b50\u6d41\u52a8\u6027\u51b3\u5b9a\u4e86\u5b83\u4eec\u7684\u7269\u7406\u7a33\u5b9a\u6027\u548c\u53cd\u5e94\u6d3b\u6027\u3002\u4e8b\u5b9e\u4e0a\uff0c\u76f8\u5206\u79bb\u548c\u7ed3\u6676\u8fc7\u7a0b\u6d89\u53ca\u6269\u6563\u548c\u6210\u6838\u4e24\u4e2a\u8fc7\u7a0b\uff0c\u8fd9\u4e24\u8005\u90fd\u9700\u8981\u8db3\u591f\u7684\u5206\u5b50\u6d41\u52a8\u6027\u3002\u8bb8\u591a\u65b9\u6cd5\u5982<\/span>Kohlrausch-William-Watts<\/span>\u65b9\u7a0b\u548c<\/span>Adam-Gibbs-Vogel<\/span>\u65b9\u7a0b\u88ab\u7528\u6765\u9884\u6d4b\u7ed3\u6784\u5f1b\u8c6b\u65b9\u9762\u7684\u5206\u5b50\u6d41\u52a8\u6027<\/span>120,121<\/span><\/sup>\u3002\u9ad8\u5206\u5b50\u6750\u6599\u4f5c\u4e3a\u975e\u6676\u6001\u836f\u7269\u7684\u8f7d\u4f53\uff0c\u5177\u6709\u9650\u5236\u975e\u6676\u6001<\/span>API<\/span>\u5206\u5b50\u6d41\u52a8\u6027\u7684\u80fd\u529b\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u975e\u6676\u6001\u836f\u7269\u56e0\u5728<\/span>PASD<\/span>\u4e2d\u7684\u5206\u5b50\u6d41\u52a8\u6027\u53d7\u9650\u800c\u5bfc\u81f4\u7ed3\u6676\u503e\u5411\u964d\u4f4e\u7684\u673a\u7406\u5bf9\u8bc4\u4f30\u5176\u7a33\u5b9a\u6027\u81f3\u5173\u91cd\u8981\u3002<\/span>DSC122<\/sup><\/span>\u3001\u56fa\u6001\u6838\u78c1\u5171\u632f\uff08<\/span>ssNMR<\/span>\uff09<\/span>123<\/span><\/sup>\u548c\u4ecb\u7535\u5149\u8c31<\/span>124<\/span><\/sup>\u5e38\u7528\u4e8e\u76d1\u6d4b\u73bb\u7483\u4f53\u7cfb\u4e2d\u7684\u5206\u5b50\u6d41\u52a8\u6027\u3002<\/span><\/span><\/p>\n

Knapik<\/span>\u7b49\u4eba<\/span>125<\/span><\/sup>\u5df2\u7ecf\u8868\u660e\uff0c\u5f53\u4f7f\u7528<\/span>Soluplus\u00ae<\/sup><\/span>\u4f5c\u4e3a\u8f7d\u4f53\u5c06\u836f\u7269\u6df7\u5165<\/span>PASD<\/span>\u65f6\uff0c\u975e\u6676\u6001\u836f\u7269\uff08\u4f9d\u6298\u9ea6\u5e03\uff09\u7684\u7269\u7406\u7a33\u5b9a\u6027\u548c\u6c34\u6eb6\u6027\u63d0\u9ad8\u4e86<\/span>6<\/span>\u500d\u4ee5\u4e0a\u3002\u901a\u8fc7<\/span>DSC<\/span>\u548c\u4ecb\u7535\u5149\u8c31\u6280\u672f\u5206\u6790\u975e\u6676\u6001\u4f9d\u6298\u9ea6\u5e03\u5f97\u51fa\u7684\u7ed3\u8bba\u662f\uff0c\u7ed3\u6784\u5f1b\u8c6b\u8fc7\u7a0b\u4e2d\u8f83\u9ad8\u7684\u5206\u5b50\u6d41\u52a8\u6027\u662f\u5176\u9ad8\u7ed3\u6676\u503e\u5411\u7684\u4e3b\u8981\u539f\u56e0\u3002\u8fd9\u8868\u660e\u5728<\/span>Soluplus\u00ae<\/sup><\/span>\u57fa\u8d28\u4e2d<\/span>PASD<\/span>\u7684\u5f62\u6210\u5bf9\u73bb\u7483\u6001\u4f9d\u6298\u9ea6\u5e03\u7684\u5206\u5b50\u8fd0\u52a8\u8d77\u5230\u4e86\u7269\u7406\u5c4f\u969c\u7684\u4f5c\u7528\uff0c\u4ece\u800c\u63d0\u9ad8\u4e86\u7a33\u5b9a\u6027\u3002<\/span>Mistry<\/span>\u7b49\u4eba<\/span>126<\/span><\/sup>\u4e5f\u8868\u660e\u8f83\u5f3a\u7684\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u529b\uff08\u79bb\u5b50\u952e\u6216\u6c22\u952e\uff09\u964d\u4f4e\u4e86\u975e\u6676\u6001\u916e\u5eb7\u5511\u7684\u5206\u5b50\u8fd0\u52a8\u80fd\u529b\uff0c\u4ece\u800c\u5ef6\u8fdf\u7ed3\u6676\u8d77\u59cb\u65f6\u95f4\u5e76\u964d\u4f4e\u5176\u7ed3\u6676\u7a0b\u5ea6\u3002\u5728<\/span>Kothari<\/span>\u7b49\u4eba<\/span>127<\/span><\/sup>\u8fdb\u884c\u7684\u53e6\u4e00\u9879\u6709\u8da3\u7684\u7814\u7a76\u4e2d\u53d1\u73b0\uff0c\u836f\u7269\u7684\u5f1b\u8c6b\u65f6\u95f4\u4f1a\u968f\u9ad8\u5206\u5b50\u6750\u6599\u6d53\u5ea6\u7684\u63d0\u9ad8\u800c\u5ef6\u957f\u3002\u7531\u6b64\u53ef\u89c1\uff0c\u836f\u7269\u7a33\u5b9a\u6027\u63d0\u9ad8\u7684\u539f\u56e0\u5f52\u7ed3\u4e8e\u964d\u4f4e\u4e86\u975e\u6676\u6001\u836f\u7269\u7684\u5206\u5b50\u6d41\u52a8\u6027\u3002<\/span><\/span><\/p>\n

PASDs<\/span><\/strong>\u4e2d\u9ad8\u5206\u5b50\u6750\u6599\u7684\u5408\u7406\u9009\u62e9<\/span><\/strong><\/span><\/p>\n

\u5728\u836f\u7269\u4f9b\u5e94\u6709\u9650\u7684\u65e9\u671f\u7814\u7a76\u9636\u6bb5\uff0c\u5bf9\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u7684\u7406\u5316\u6027\u8d28\uff08\u5982\u5316\u5b66\u7ed3\u6784\u3001\u5206\u5b50\u91cf\u3001<\/span>Tm<\/span>\u6216<\/span>Tg<\/span>\u503c\u3001\u7194\u878d\u7113\u548c\u71b5\u3001\u4f4e\u4e8e\u548c\u9ad8\u4e8e<\/span>Tg<\/span>\u7684\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u7684\u7c98\u5ea6\u3001\u7ed3\u6784\u7684\u7075\u6d3b\u6027\u3001\u590d\u6742\u6027\u548c\u5bf9\u79f0\u6027\u3001\u6709\u52a9\u4e8e\u6210\u952e\u7684\u5b98\u80fd\u56e2\u7b49\uff09\u8fdb\u884c\u8868\u5f81\u548c\u5173\u8054\u662f\u975e\u5e38\u91cd\u8981\u7684\u3002\u5982\u524d\u6240\u8ff0\uff0c\u7531\u4e8e\u5176\u5bf9\u975e\u6676\u6001\u836f\u7269\u7684\u6297\u5851\u5316\u4f5c\u7528\uff0c\u901a\u5e38\u9009\u62e9\u9ad8\u6d53\u5ea6\u5e76\u4e14\u9ad8<\/span>Tg<\/span>\u503c\u7684\u9ad8\u5206\u5b50\u6750\u6599\u6765\u5236\u5907<\/span>ASDs<\/span>\u3002\u7136\u800c\uff0c\u5728\u9ad8\u5206\u5b50\u6750\u6599\u91cd\u91cf\u5206\u6570\u8f83\u4f4e\u7684\u60c5\u51b5\u4e0b\uff0c\u5374\u6ca1\u6709\u89c2\u5bdf\u5230\u975e\u6676\u6001\u836f\u7269\u548c\u56fa\u4f53\u5206\u6563\u4f53\u4e4b\u95f4<\/span>Tg<\/span>\u7684\u5dee\u5f02\uff0c\u901a\u5e38\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5c06\u51b3\u5b9a\u5b83\u4eec\u7684\u4fdd\u8d28\u671f<\/span>128<\/span><\/sup>\u3002\u5206\u5b50\u91cf\u7684\u589e\u52a0\u63d0\u9ad8\u4e86\u9ad8\u5206\u5b50\u6750\u6599\u7684<\/span>Tg<\/span>\u503c\uff0c\u8fd9\u4fc3\u8fdb\u4e86\u975e\u6676\u6001\u836f\u7269\u7684\u6297\u5851\u5316\u4f5c\u7528<\/span>129<\/span><\/sup>\u3002\u800c\u5728\u5206\u5b50\u91cf\u8db3\u591f\u9ad8\u65f6\uff0c\u968f\u7740\u7c98\u5ea6\u7b49\u5176\u5b83\u56e0\u7d20\u5728\u6eb6\u89e3\u8fc7\u7a0b\u4e2d\u53d1\u6325\u4f5c\u7528\uff0c<\/span>Tg<\/span>\u503c\u7684\u5347\u9ad8\u53d8\u5f97\u65e0\u5173\u7d27\u8981\u3002\u9ad8\u5206\u5b50\u6750\u6599\u7684\u7c98\u5ea6\u968f\u5206\u5b50\u91cf\u7684\u589e\u52a0\u800c\u589e\u52a0\uff0c\u8fd9\u5bf9\u9ad8\u5206\u5b50\u6750\u6599\u7684\u6eb6\u89e3\u6027\u80fd\u6709\u7740\u663e\u8457\u5f71\u54cd<\/span>130<\/span><\/sup>\u3002\u6b64\u5916\uff0c\u9ad8\u5206\u5b50\u6750\u6599\u8fd8\u5e94\u5177\u6709\u4e0e\u836f\u7269\u76f8\u4f3c\u7684\u4f4e\u7194\u70b9\u548c\u6eb6\u89e3\u5ea6\u53c2\u6570\u3002\u540c\u65f6\uff0c\u4ed6\u4eec\u4e4b\u95f4\u7684\u53ef\u6df7\u6eb6\u7a0b\u5ea6\u4e5f\u5f88\u91cd\u8981\uff0c\u56e0\u4e3a\u9ad8\u5ea6\u6df7\u6eb6\u7684\u4f53\u7cfb\u5bf9\u836f\u7269\u7684\u518d\u7ed3\u6676\u884c\u4e3a\u62b5\u6297\u529b\u66f4\u5f3a<\/span>131<\/span><\/sup>\u3002\u80fd\u5426\u5f62\u6210\u7a33\u5b9a\u7684\u5355\u76f8\u6216\u8005\u5355\u72ec\u5171\u5b58\u76f8\u4f53\u7cfb\u5219\u53d6\u51b3\u4e8e\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u5728\u6240\u9700\u6761\u4ef6\u4e0b\u7684\u70ed\u529b\u5b66\u6df7\u6eb6\u6027\u3002\u6761\u4ef6\u7684\u6539\u53d8\u53ef\u80fd\u5f15\u8d77\u5747\u5300\u5355\u76f8\u4f53\u7cfb\u7684\u76f8\u5206\u79bb\uff08\u8868<\/span>3<\/span>\uff09\u3002\u56e0\u6b64\uff0c\u5728\u9009\u62e9\u9002\u5408\u7684\u9ad8\u5206\u5b50\u6750\u6599\u8f7d\u4f53\u65f6\uff0c\u5fc5\u987b\u7efc\u5408\u8003\u8651\u8fd9\u4e9b\u76f8\u4e92\u5bf9\u7acb\u7684\u9700\u6c42\u3002\u4ee5\u4e0b\u5404\u8282\u5c06\u8ba8\u8bba\u4e0d\u540c\u7684\u6280\u672f\u624b\u6bb5\uff0c\u5982\u6eb6\u89e3\u5ea6\u53c2\u6570\u6cd5\u3001<\/span>Flory-Huggins<\/span>\u7406\u8bba\u3001\u7194\u878d\u7113\u6cd5\u548c\u5206\u5b50\u6a21\u62df\u6cd5\u7b49\uff0c\u4f5c\u4e3a\u5408\u7406\u9009\u62e9\u9ad8\u5206\u5b50\u6750\u6599\u7684\u836f\u7269\u914d\u65b9\u8bbe\u8ba1\u5de5\u5177\u3002<\/span><\/span><\/p>\n

\u6eb6\u89e3\u5ea6\u53c2\u6570\u6cd5<\/span><\/strong><\/p>\n

\u901a\u8fc7\u5b9e\u9a8c\u6d4b\u5b9a\u836f\u7269\u5728\u9ad8\u5206\u5b50\u6750\u6599\u4e2d\u7684\u6eb6\u89e3\u5ea6\u662f\u5341\u5206\u5177\u6709\u6311\u6218\u6027\u7684\u3002\u4f46\u662f\uff0c\u5374\u53ef\u4ee5\u5229\u7528\u6eb6\u89e3\u5ea6\u53c2\u6570\u6cd5\u5bf9\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u6df7\u6eb6\u6027\u8fdb\u884c\u5b9a\u6027\u8bc4\u4f30\u3002\u6eb6\u89e3\u5ea6\u53c2\u6570\u7b49\u4e8e\u5185\u805a\u80fd\u5bc6\u5ea6\uff08\u51dd\u805a\u6001\u6750\u6599\u5185\u7684\u603b\u5438\u5f15\u529b\uff09\u7684\u5e73\u65b9\u6839\uff0c\u5982\u4e0b\u6240\u793a\uff08\u65b9\u7a0b<\/span>5<\/span>\uff09<\/span>132<\/span><\/sup>\uff1a<\/span><\/span><\/p>\n

\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a<\/p>\n

\u5176\u4e2d<\/span>                             <\/span>\u662f<\/span>Fedor<\/span>\u6eb6\u89e3\u5ea6\u53c2\u6570\uff0c<\/span>CED<\/span>\u662f\u5185\u805a\u80fd\u5bc6\u5ea6\uff0c<\/span><\/span>\u662f\u6c7d\u5316\u80fd\uff0c<\/span>Vm<\/span>\u662f\u6469\u5c14\u4f53\u79ef\u3002\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u7684\u5185\u805a\u80fd\u5bc6\u5ea6\u503c\u76f8\u4f3c\u8868\u660e\uff0c\u7834\u574f\u4e24\u4e2a\u76f8\u4f3c\u5206\u5b50\u95f4\u76f8\u4e92\u4f5c\u7528\u6240\u9700\u7684\u80fd\u91cf\u8f83\u5c0f\uff0c\u56e0\u4e3a\u6240\u9700\u80fd\u91cf\u5c06\u7531<\/span>2<\/span>\u4e2a\u4e0d\u540c\u5206\u5b50\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u91ca\u653e\u7684\u80fd\u91cf\u8fdb\u884c\u8865\u507f\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u7ed3\u5408\u80fd\u8fd8\u53d6\u51b3\u4e8e\u6781\u6027\u57fa\u56e2\u548c\u6c22\u952e\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u901a\u8fc7\u4f7f\u7528<\/span>Hoftyzer<\/span>\u548c<\/span>Van Krevelen<\/span>\u7684\u5206\u6790\u65b9\u6cd5\u53ef\u4ee5\u66f4\u597d\u5730\u9884\u6d4b\u76f8\u4e92\u4f5c\u7528\u7684\u5927\u5c0f\uff0c\u5982\u4e0b\u5f0f\u6240\u793a\uff08\u65b9\u7a0b<\/span>6<\/span>\u548c<\/span>7<\/span>\uff09<\/span>133<\/span><\/sup>\uff1a<\/span><\/span><\/p>\n

\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a<\/p>\n

\u5176\u4e2d<\/span>    <\/span><\/span>\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a    <\/span>\uff08\u65b9\u7a0b<\/span>6<\/span>\u548c<\/span>7<\/span>\u4e2d\uff09\u5206\u5c5e\u4e8e\u8272\u6563\u529b\uff0c\u6781\u6027\u529b\u548c\u6c22\u952e\uff1b<\/span><\/span>\u4e3a\u603b\u6eb6\u89e3\u5ea6\u53c2\u6570\uff1b<\/span><\/span>\u662f\u7531\u8272\u6563\u7ec4\u5206\u5f15\u8d77\u7684\u6469\u5c14\u5f15\u529b\u5e38\u6570\uff1b<\/span><\/span>\u662f\u7531\u6781\u6027\u7ec4\u5206\u5f15\u8d77\u7684\u6469\u5c14\u5f15\u529b\u5e38\u6570\uff1b<\/span><\/span>\u662f\u6c22\u952e\u80fd\uff1b<\/span>V<\/span>\u662f\u6469\u5c14\u4f53\u79ef\u3002\u5176\u4ed6\u6eb6\u89e3\u5ea6\u53c2\u6570\u8ba1\u7b97\u65b9\u6cd5\uff0c\u5982<\/span>Hoy<\/span>\u3001<\/span>Small<\/span>\u3001<\/span>Dunkel<\/span>\u3001<\/span>Hayes<\/span>\u548c<\/span>DiBenedetto<\/span>\u7b49\u4e5f\u5728\u6587\u732e\u4e2d\u6709\u6240\u62a5\u9053<\/span>134<\/span><\/sup>\u3002\u4e00\u822c\u8ba4\u4e3a\uff0c<\/span><\/span>\u503c\u8f83\u4f4e\u7684\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4f53\u7cfb\u66f4\u6613\u6df7\u6eb6\u3002<\/span><\/span>7.0 MPa1\/2<\/sup><\/span>\u7684\u4f53\u7cfb\u662f\u53ef\u6df7\u6eb6\u7684\uff0c\u800c<\/span><\/span>10.0 MPa1\/2<\/sup><\/span>\u7684\u4f53\u7cfb\u5f88\u53ef\u80fd\u662f\u4e0d\u6df7\u6eb6\u7684<\/span>135<\/span><\/sup>\u3002\u8be5\u65b9\u6cd5\u867d\u7136\u88ab\u5e7f\u6cdb\u4f7f\u7528\uff0c\u4f46\u4e5f\u6709\u4e00\u5b9a\u7684\u5c40\u9650\u6027\u3002\u8fd9\u79cd\u8ba1\u7b97\u7406\u8bba\u9002\u7528\u4e8e\u8303\u5fb7\u534e\u529b\u8d77\u4e3b\u8981\u76f8\u4e92\u4f5c\u7528\u7684\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4f53\u7cfb\uff0c\u800c\u5bf9\u4e8e\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u6df7\u5408\u7269\u4e4b\u95f4\u5f62\u6210\u9ad8\u5ea6\u5b9a\u5411\u7684\u76f8\u4e92\u4f5c\u7528\uff08\u5982\u6c22\u952e\u6216\u79bb\u5b50\u95f4\u4f5c\u7528\u7b49\u957f\u7a0b\u529b\uff09\uff0c\u5219\u4f1a\u5f97\u51fa\u9519\u8bef\u7684\u7ed3\u679c<\/span>136<\/span><\/sup>\u3002<\/span><\/p>\n

Flory-Huggins<\/span>\u7406\u8bba<\/span><\/span><\/p>\n

Flory-Huggins<\/span>\uff08<\/span>FH<\/span>\uff09\u7406\u8bba\u662f\u4f17\u6240\u5468\u77e5\u7684\u4e00\u79cd\u57fa\u4e8e\u6676\u683c\u6a21\u578b\u7684\u7406\u8bba\uff0c\u5b83\u7528\u9ad8\u5206\u5b50\u6750\u6599\u6df7\u5408\u4e8e\u6eb6\u5242\u4e2d\u4ea7\u751f\u7684\u5409\u5e03\u65af\u81ea\u7531\u80fd\u53d8\u5316\u6765\u63cf\u8ff0\u9ad8\u5206\u5b50\u6750\u6599<\/span>–<\/span>\u6eb6\u5242\u4e4b\u95f4\u7684\u6df7\u6eb6\u6027<\/span>137<\/span><\/sup>\u3002\u6700\u8fd1\uff0c\u8fd9\u4e00\u7406\u8bba\u88ab\u5e94\u7528\u4e8e\u8bc4\u4f30\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u6df7\u6eb6\u6027\uff0c\u91c7\u7528\u7194\u70b9\u964d\u4f4e\u6cd5\u5f97\u5230<\/span>FH<\/span>\u7684\u76f8\u4e92\u4f5c\u7528\u53c2\u6570<\/span><\/span>\uff0c\u7ecf<\/span>Nishi-Wang<\/span>\u4fee\u6b63\u7684<\/span>FH<\/span>\u65b9\u7a0b\uff08\u65b9\u7a0b<\/span>8)<\/span>\u5982\u4e0b\u6240\u793a<\/span>138<\/span><\/sup>\uff1a<\/span><\/span><\/p>\n

\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a<\/p>\n

\u5176\u4e2d<\/span>  <\/span><\/span>\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a\u5206\u522b\u4e3a\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u7684\u7269\u7406\u6df7\u5408\u7269\u548c\u7eaf\u836f\u7269\u7684\u7194\u70b9\uff1b<\/span><\/span>\u662f\u7eaf\u836f\u7269\u7684\u7194\u878d\u7113\uff1b<\/span><\/span>\u548c<\/span><\/span>\u5206\u522b\u662f\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u7684\u4f53\u79ef\u5206\u6570\uff1b<\/span>m<\/span>\u662f\u9ad8\u5206\u5b50\u6750\u6599\u4f53\u79ef\u4e0e\u836f\u7269\u4f53\u79ef\u4e4b\u6bd4\u3002\u901a\u8fc7\u65b9\u7a0b\u7684\u5de6\u4fa7\u90e8\u5206\u4e0e<\/span><\/span>\u4f5c\u56fe\u5f97\u5230\u7684\u76f4\u7ebf\u659c\u7387\u5c06\u5f97\u51fa<\/span>FH<\/span>\u76f8\u4e92\u4f5c\u7528\u53c2\u6570\u7684\u503c\uff0c<\/span><\/span>\u3002\u8d1f\u503c\u7684<\/span><\/span>\u8868\u793a\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u6bd4\u5355\u4e2a\u836f\u7269\u4e4b\u95f4\u6216\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u66f4\u5f3a\uff0c\u5e76\u4ee5\u6b64\u9884\u6d4b\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u7684\u6df7\u6eb6\u6027\uff1b\u800c\u6b63\u503c\u8868\u793a\u540c\u6838\u95f4\u65a5\u529b\u9ad8\u4e8e\u5f02\u6838\u7684\u5438\u5f15\u529b\uff0c\u8fd9\u53ef\u80fd\u5bfc\u81f4\u53d1\u751f\u76f8\u5206\u79bb<\/span>139-141<\/span><\/sup>\u3002<\/span><\/p>\n

\u7194\u878d\u7113\u6cd5<\/span><\/strong><\/p>\n

ASD<\/span>\u7684\u7269\u7406\u7a33\u5b9a\u6027\u4e3b\u8981\u53d6\u51b3\u4e8e\u50a8\u5b58\u6e29\u5ea6\u4e0b\u836f\u7269\u5728\u9ad8\u5206\u5b50\u6750\u6599\u4e2d\u7684\u6eb6\u89e3\u5ea6\u3002\u521d\u6b65\u786e\u5b9a\u836f\u7269\u5728\u7279\u5b9a\u9ad8\u5206\u5b50\u6750\u6599\u4e2d\u7684\u6eb6\u89e3\u5ea6\u53ef\u4f5c\u4e3a\u7b5b\u9009\u6761\u4ef6\uff0c\u5373\u6eb6\u89e3\u8f83\u9ad8\u836f\u7269\u91cd\u91cf\u5206\u6570\u7684\u9ad8\u5206\u5b50\u6750\u6599\u53ef\u8fdb\u4e00\u6b65\u7528\u4e8e<\/span>ASD<\/span>\u7684\u4e0b\u6e38\u5904\u7406\u3002\u7528\u4e8e\u4f30\u8ba1\u836f\u7269\u5728\u9ad8\u5206\u5b50\u6750\u6599\u4e2d\u6eb6\u89e3\u5ea6\u7684\u6700\u5e7f\u6cdb\u4f7f\u7528\u7684\u65b9\u6cd5\u662f\u901a\u8fc7<\/span>Hyper DSC<\/span>\u6d4b\u91cf\u7684\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4f53\u7cfb\u4e2d\u7ed3\u6676\u836f\u7269\u7684\u7194\u878d\u7113<\/span>142<\/span><\/sup>\u3002\u8be5\u65b9\u6cd5\u57fa\u4e8e\u4e00\u4e2a\u7b80\u5355\u7684\u539f\u7406\uff0c\u5373\u6eb6\u89e3\u5728\u9ad8\u5206\u5b50\u6750\u6599\u4e2d\u7684\u836f\u7269\u90e8\u5206\u4e0d\u4f1a\u5bfc\u81f4\u7194\u878d\u5438\u70ed\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u6d4b\u91cf\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u6df7\u5408\u7269\u4e2d\u4e00\u7cfb\u5217\u836f\u7269\u6d53\u5ea6\u7684\u7194\u878d\u7113\uff0c\u5e76\u5c06\u66f2\u7ebf\u5916\u63a8\u81f3\u96f6\u7113\u503c\uff0c\u7ed9\u5b9a\u836f\u7269\u5728\u9009\u5b9a\u9ad8\u5206\u5b50\u6750\u6599\u4e2d\u7684\u6eb6\u89e3\u5ea6\u4fbf\u53ef\u7531\u7ed8\u5236\u66f2\u7ebf\u5728<\/span>x<\/span>\u8f74\u7684\u622a\u8ddd\u8fdb\u884c\u4f30\u7b97\uff0c\u5982\u56fe<\/span>9<\/span>\u6240\u793a\u3002<\/span><\/span><\/p>\n

\u5206\u5b50\u6a21\u62df\u6cd5<\/span><\/strong><\/p>\n

\u5e94\u7528\u73b0\u4ee3\u7684\u8ba1\u7b97\u673a\u8bbe\u5907\u5bf9\u539f\u5b50\u548c\u5206\u5b50\u8fdb\u884c\u6a21\u62df\u4e3a\u6211\u4eec\u63a2\u6d4b\u4e0d\u540c\u4f53\u7cfb\u5206\u5b50\u7684\u8fd0\u52a8\u8fc7\u7a0b\u63d0\u4f9b\u4e86\u5f3a\u5927\u7684\u6280\u672f\u4fdd\u969c\uff0c\u53ef\u4ee5\u5bf9\u7528\u5b9e\u9a8c\u65b9\u6cd5\u65e0\u6cd5\u826f\u597d\u8868\u5f81\u7684\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\u7684\u70ed\u529b\u5b66\u884c\u4e3a\u8fdb\u884c\u9884\u6d4b<\/span>143<\/span><\/sup>\u3002\u8bf8\u5982<\/span>GROMACS<\/span>\u7684\u6240\u6709\u539f\u5b50\u573a\u57df\u7a0b\u5e8f\u5305\u3001<\/span> MonteCarlo<\/span>\u6a21\u62df\u7a0b\u5e8f\u3001\u4f7f\u7528<\/span>Cerius2<\/span>\u6a21\u5757\u7684<\/span>Dreiding2.21<\/span>\u5206\u5b50\u529b\u573a\u6d4b\u91cf\u8f6f\u4ef6\u3001<\/span>SYBYL\/MMFF94<\/span>\u529b\u573a\u6d4b\u91cf\u8f6f\u4ef6\u4ee5\u53ca\u4f7f\u7528\u5bc6\u5ea6\u6cdb\u51fd\u7406\u8bba\u7684<\/span>Gaussian09<\/span>\u8f6f\u4ef6\u7b49\u8ba1\u7b97\u673a\u6a21\u62df\u5de5\u5177\u8f6f\u4ef6\u5df2\u7ecf\u6210\u529f\u5730\u88ab\u5e94\u7528\u4e8e<\/span>PASD<\/span>\u4f53\u7cfb\uff0c\u7528\u6765\u4e86\u89e3\u73bb\u7483\u5316\u8f6c\u53d8\u3001\u7ed3\u6676\u8d8b\u52bf\u3001\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u548c\u7a33\u5b9a\u6027<\/span>144<\/span><\/sup>\u3002\u8fd9\u4e9b\u7ed3\u5408<\/span>FH<\/span>\u7406\u8bba\u7684\u6a21\u62df\u5de5\u5177\u8f6f\u4ef6\u4e5f\u88ab\u7528\u4e8e\u8bc4\u4f30\u836f\u7269\u5728\u8102\u8d28\u8f7d\u4f53\u4e2d\u7684\u6eb6\u89e3\u5ea6<\/span>145<\/span><\/sup>\u3002\u6b64\u5916\uff0c\u5e94\u7528\u539f\u5b50\u6a21\u62df\u7814\u7a76\u51dd\u805a\u76f8\u4f18\u5316\u5206\u5b50\u52bf\u80fd\u53ef\u4ee5\u9884\u6d4b\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4f53\u7cfb\u7684\u6eb6\u89e3\u5ea6\u53c2\u6570<\/span>146<\/span><\/sup>\u3002\u540c\u65f6\uff0c\u57fa\u4e8e\u5bc6\u5ea6\u6cdb\u51fd\u7406\u8bba\u7684<\/span>B3LYP<\/span>\u4ea4\u6362\u76f8\u5173\u51fd\u6570\u5219\u7ed9\u51fa\u4e86\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u7684\u5408\u7406\u4f30\u8ba1\u503c<\/span>(<\/span>\u89c1\u56fe<\/span>8)118<\/sup><\/span>\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u5728\u8ba1\u7b97\u673a\u4e0a\u8fdb\u884c\u7684\u5206\u5b50\u6a21\u62df\u662f\u4e00\u79cd\u5f3a\u5927\u7684\u836f\u7269\u914d\u65b9\u8bbe\u8ba1\u5de5\u5177\uff0c\u5b83\u53ef\u4ee5\u8ba9\u7814\u7a76\u4eba\u5458\u5408\u7406\u7b5b\u9009\u5e94\u7528\u4e8e<\/span>PASDs<\/span>\u7684\u9ad8\u5206\u5b50\u6750\u6599<\/span>147<\/span><\/sup>\u3002<\/span><\/span><\/p>\n

\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a<\/p>\n

\u56fe<\/span>9 <\/span>\u7194\u878d\u7113\u4f5c\u4e3a\u8868\u5f81\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u7269\u7406\u6df7\u5408\u7269\u4e2d\u4e0d\u540c\u836f\u7269\u8f7d\u8377\u7684\u51fd\u6570\uff0c\u63ed\u793a\u4e86\u7eaf\u836f\u7269\u90e8\u5206\u5bf9\u7194\u878d\u7113\u7684\u5f71\u54cd\uff1b\u8be5\u8f6c\u8f7d\u5df2\u7ecf<\/span>Amharar<\/span>\u5141\u8bb8<\/span>142<\/span><\/sup>\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u975e\u6676\u6001\u836f\u7269\u5728\u9ad8\u5206\u5b50\u6750\u6599\u4e2d\u7684\u5206\u6563\u65b9\u6cd5<\/span><\/strong><\/span><\/p>\n

\u73b0\u6709\u6587\u732e\u62a5\u9053\u4e86\u8bb8\u591a\u5173\u4e8e\u56fa\u4f53\u5206\u6563\u4f53\u7684\u5236\u5907\u65b9\u6cd5\uff08\u8868<\/span>2<\/span>\uff09\uff0c\u5176\u4e2d\u5305\u62ec\u7eb3\u7c73\u60ac\u6d6e\u6cd5\u3001\u51b7\u51bb\u6cd5\u3001\u73af\u7cca\u7cbe\u5305\u5408\u6cd5\u3001\u9759\u7535\u7eba\u4e1d\u6cd5\u3001\u9759\u7535\u5439\u5851\u6cd5\u3001<\/span><\/span>\u7535\u55b7\u96fe\u6d82\u819c\u94f8\u5851\u6cd5<\/span>\u3001\u52a9\u6eb6\u5242\u6cd5\u548c\u673a\u68b0\u6d3b\u5316\u6cd5\u7b49<\/span>148<\/span><\/sup>\u3002\u8fd9\u4e9b\u5236\u5907\u6280\u672f\u5747\u662f\u4f9d\u8d56\u4e8e\u8bf8\u5982\u80f6\u675f\u589e\u6eb6\u3001\u7edc\u5408\u4f5c\u7528\u3001\u589e\u52a0\u5b54\u9699\u7387\u6216\u964d\u4f4e\u7c92\u5f84\u7b49\u673a\u5236\u6765\u5b9e\u73b0\u589e\u6eb6\u4f5c\u7528\u7684\uff0c\u5e94\u4e0e\u7531\u9ad8\u5206\u5b50\u6750\u6599\u6784\u6210\u7684<\/span>ASD<\/span>\u533a\u5206\u5f00\u6765\u3002\u7531\u4e8e\u914d\u65b9\u7b56\u7565\u7b80\u5355\u3001\u6613\u4e8e\u653e\u5927\u548c\u6210\u672c\u8f83\u4f4e\uff0c\u4e8c\u5143\u4f53\u7cfb\u5df2\u6210\u4e3a\u6700\u5e38\u7528\u7684<\/span>ASDs<\/span>\u5236\u5907\u65b9\u6cd5<\/span>149<\/span><\/sup>\u3002\u6839\u636e\u914d\u65b9\u7684\u8981\u6c42\u548c\u836f\u7269\u7684\u7a33\u5b9a\u6027\uff0c\u6709\u65f6\u4e5f\u4f1a\u4f7f\u7528\u66f4\u590d\u6742\u7684\u4e09\u5143\u548c\u56db\u5143\u4f53\u7cfb\u8fdb\u884c\u5236\u5907<\/span>150<\/span><\/sup>\u3002\u867d\u7136\u4f7f\u7528\u8868\u9762\u6d3b\u6027\u5242\u4f1a\u589e\u52a0<\/span>ASDs<\/span>\u7684\u7a33\u5b9a\u6027\u548c\u6eb6\u89e3\u5ea6\uff0c\u4f46\u4e5f\u4f1a\u589e\u52a0\u5236\u5907\u8fc7\u7a0b\u7684\u590d\u6742\u6027\uff0c\u800c\u4e14\u65e0\u6cd5\u4fdd\u8bc1\u5176\u5728\u4f53\u5185\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027<\/span>151<\/span><\/sup>\u3002\u6b64\u5916\uff0c\u5728\u8bbe\u8ba1\u5de5\u827a\u65f6\uff0c\u8fd8\u5e94\u6ee1\u8db3\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u5747\u5300\u6df7\u5408\u7b49\u8981\u6c42\u3002\u5728\u8fdb\u884c\u6280\u672f\u9009\u62e9\u65f6\u5fc5\u987b\u6ce8\u610f\u907f\u514d\u5206\u5c42\u6216\u76f8\u5206\u79bb\u73b0\u8c61\u7684\u4ea7\u751f\u3002\u5728\u5236\u5907\u8fc7\u7a0b\u4e2d\u7ecf\u5e38\u901a\u8fc7\u9650\u5236\u975e\u6676\u6001\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u7684\u5206\u5b50\u6d41\u52a8\u6027\uff0c\u907f\u514d\u76f8\u5206\u79bb\u6216\u518d\u7ed3\u6676\u884c\u4e3a\u3002\u672c\u6587\u8ba8\u8bba\u4e86\u4e09\u79cd\u4e0d\u540c\u7684\u56fa\u4f53\u5206\u6563\u4f53\u5236\u5907\u65b9\u6cd5\uff08\u56fe<\/span>10<\/span>\uff09\u3002\u6709\u5173\u5236\u5907\u6280\u672f\u7684\u66f4\u591a\u4fe1\u606f\u53ef\u4ee5\u5728\u4e00\u4e9b\u4f18\u79c0\u7684\u6587\u732e\u7efc\u8ff0\u4e2d\u627e\u5230<\/span>152<\/span><\/sup>\u3002<\/span><\/span><\/span><\/p>\n

\u7194\u878d\u6cd5<\/span><\/p>\n

\u7194\u878d\u6cd5\uff0c\u4e5f\u79f0\u4e3a\u7194\u5316\u6cd5<\/span><\/span><\/strong>\uff0c\u6700\u65e9\u662f\u7531<\/span>Sekiguchi<\/span>\u548c<\/span>Obi<\/span>\u5728<\/span>1961<\/span>\u5e74\u63d0\u51fa\u7684<\/span>153<\/span><\/sup>\u3002\u5c06\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u7684\u7269\u7406\u6df7\u5408\u7269\u52a0\u70ed\u81f3\u7194\u878d\u72b6\u6001\uff0c\u5e76\u5728\u6301\u7eed\u6405\u62cc\u4e0b\u51b7\u5374\u56fa\u5316\u3002\u7136\u540e\u5bf9\u6240\u5f97\u56fa\u4f53\u7269\u8d28\u538b\u788e\u3001\u5236\u7c89\u3001\u8fc7\u7b5b\uff0c\u83b7\u5f97\u6240\u9700\u7684\u7c92\u5f84\u3002\u8be5\u65b9\u6cd5\u5c3d\u7ba1\u88ab\u7ecf\u5e38\u4f7f\u7528\uff0c\u4f46\u5728\u5236\u5907\u56fa\u4f53\u5206\u6563\u4f53\u65f6\u4ecd\u5b58\u5728\u8bb8\u591a\u6311\u6218\uff0c\u4f8b\u5982\u5728\u52a0\u70ed\u6e29\u5ea6\u4e0b\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u7684\u6df7\u6eb6\u6027\u4e0d\u4f73\u3002\u5f53\u7136\uff0c\u8be5\u95ee\u9898\u53ef\u4ee5\u901a\u8fc7\u52a0\u5165\u8868\u9762\u6d3b\u6027\u5242\u6765\u89e3\u51b3<\/span>154<\/span><\/sup>\u3002\u6b64\u5916\uff0c\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u5fc5\u987b\u5728<\/span>Tm<\/span>\u65f6\u4fdd\u6301\u70ed\u7a33\u5b9a\u6027\uff0c\u56e0\u6b64\uff0c\u5e94\u9996\u9009\u8f83\u4f4e\u7684\u52a0\u5de5\u6e29\u5ea6<\/span>155<\/span><\/sup>\u3002\u53e6\u5916\uff0c\u7194\u878d\u6df7\u5408\u7269\u5fc5\u987b\u80fd\u591f\u5728\u4ea7\u54c1\u7684\u4fdd\u8d28\u671f\u5185\u4fdd\u6301\u7a33\u5b9a\u72b6\u6001\uff0c\u907f\u514d\u53d1\u751f\u518d\u7ed3\u6676\u548c\u76f8\u5206\u79bb\u884c\u4e3a\u3002<\/span>Sheng<\/span>\u7b49\u4eba<\/span>156<\/span><\/sup>\u62a5\u9053\u4e86\u975e\u6d1b\u5730\u5e73<\/span>–<\/span>\u4e19\u70ef\u9178\u6811\u8102\u914d\u65b9\u4e2d\uff0c\u7531\u4e8e\u975e\u6676\u6001\u836f\u7269\u7684\u8fc7\u9971\u548c\u72b6\u6001\u5f15\u53d1\u4e86\u76f8\u5206\u79bb\u7684\u8001\u5316\u884c\u4e3a\u3002<\/span>Save<\/span>\u7b49\u4eba<\/span>157<\/span><\/sup>\u4e5f\u62a5\u9053\u79f0\u5728\u7f13\u6162\u51b7\u5374\u785d\u82ef\u5730\u5e73<\/span>-PEG 6000<\/span>\u914d\u65b9\u7684\u7194\u878d\u6df7\u5408\u7269\u65f6\u51fa\u73b0\u4e86\u7c7b\u4f3c\u7684\u7ed3\u679c\u3002<\/span><\/span><\/p>\n

\u70ed\u7194\u6324\u51fa\u6cd5\u662f\u7194\u878d\u6cd5\u7684\u8fdb\u9636\u7248\u672c<\/span><\/span><\/strong>\uff0c\u8be5\u65b9\u6cd5\u5e94\u7528\u6324\u51fa\u673a\u5c06\u5404\u7ec4\u5206\u8fdb\u884c\u5267\u70c8\u6df7\u5408\u3002\u4e0e\u4f20\u7edf\u7684\u7194\u878d\u6cd5\u76f8\u6bd4\uff0c\u70ed\u7194\u6324\u51fa\u6cd5\u8d4b\u4e88\u4e86\u5c06\u7194\u878d\u7684\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6df7\u5408\u7269\u5236\u6210\u690d\u5165\u7269\u3001\u5fae\u7403\u6216\u53e3\u670d\u5242\u578b\u7684\u6f5c\u529b<\/span>158<\/span><\/sup>\u3002\u8fd9\u79cd\u65b9\u6cd5\u8981\u6c42\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u5728\u7194\u878d\u72b6\u6001\u4e0b\u80fd\u591f\u5b8c\u5168\u6df7\u6eb6\u3002\u6eb6\u89e3\u5ea6\u53c2\u6570\u76f8\u56fe\u53ef\u7528\u4e8e\u9884\u6d4b\u76f8\u5bb9\u6027\uff0c\u5bf9\u53ef\u6df7\u6eb6\u7684\u9ad8\u5206\u5b50\u6750\u6599\u8fdb\u884c\u5408\u7406\u9009\u62e9\u3002\u8be5\u6280\u672f\u5177\u6709\u4ee5\u4e0b\u51e0\u4e2a\u4f18\u70b9\uff1a\uff08<\/span>1<\/span>\uff09\u8be5\u65b9\u6cd5\u4e0d\u4f7f\u7528\u6eb6\u5242\uff1b\uff08<\/span>2<\/span>\uff09\u52a0\u5de5\u6b65\u9aa4\u66f4\u5c11\uff0c\u56e0\u4e3a\u6ca1\u6709\u5bf9\u6750\u6599\u538b\u7f29\u7684\u8fc7\u7a0b\u4e14\u4e0d\u9700\u8981\u5bf9\u4ea7\u54c1\u8fdb\u884c\u5e72\u71e5\uff0c\u8fd9\u4f7f\u5f97\u8be5\u5de5\u827a\u66f4\u52a0\u7b80\u5355\u3001\u8fde\u7eed\u3001\u9ad8\u6548\uff1b\uff08<\/span>3<\/span>\uff09\u5728\u9ad8\u526a\u5207\u901f\u7387\u548c\u9ad8\u6e29\u6761\u4ef6\u4e0b\u5f7b\u5e95\u6df7\u5408\u4f1a\u4f7f\u9897\u7c92\u89e3\u805a\uff08\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u5206\u6563\uff09\uff0c\u4f7f\u836f\u7269\u9897\u7c92\u5747\u5300\u5206\u5e03\u4e8e\u9ad8\u5206\u5b50\u57fa\u4f53\u4e2d<\/span>159<\/span><\/sup>\u3002\u6b64\u5916\uff0c\u4e0e\u4f20\u7edf\u7684\u878d\u5408\u65b9\u6cd5\u76f8\u6bd4\uff0c\u8be5\u6280\u672f\u63d0\u4f9b\u4e86\u8fde\u7eed\u52a0\u5de5\u7684\u53ef\u80fd\uff0c\u4f7f\u5176\u9002\u7528\u4e8e\u5927\u89c4\u6a21\u751f\u4ea7\u3002\u9002\u7528\u4e8e\u70ed\u7194\u6324\u51fa\u6cd5\u7684\u5e38\u7528\u9ad8\u5206\u5b50\u6750\u6599\u5305\u62ec<\/span>HPMC<\/span>\u3001<\/span>HPMCAS<\/span>\u3001<\/span>PVP<\/span>\u3001<\/span>PVP-<\/span>\u918b\u9178\u4e59\u70ef\u916f\u548c\u805a\u73af\u6c27\u4e59\u70f7\u7b49\uff08\u8868<\/span>2<\/span>\uff09<\/span>160<\/span><\/sup>\u3002<\/span><\/span><\/p>\n

\u6eb6\u5242\u6cd5<\/span><\/strong><\/p>\n

\u6eb6\u5242\u6cd5\u662f\u4f7f\u7528\u4e00\u79cd\u6eb6\u5242\u5c06\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u5236\u5907\u6210\u5747\u5300\u6eb6\u6db2\uff0c\u7136\u540e\u9664\u53bb\u6eb6\u5242\uff0c\u5f97\u5230\u56fa\u4f53\u5206\u6563\u4f53\u3002\u8be5\u65b9\u6cd5\u80fd\u591f\u5b9e\u73b0\u5206\u5b50\u6c34\u5e73\u7684\u6df7\u5408\uff0c\u6709\u5229\u4e8e\u63d0\u9ad8\u4ea7\u54c1\u7684\u6eb6\u89e3\u5ea6\u548c\u7a33\u5b9a\u6027\u3002\u5176\u4e3b\u8981\u4f18\u70b9\u662f\u53ef\u4ee5\u9632\u6b62\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u53d7\u70ed\u5206\u89e3\uff0c\u56e0\u4e3a\u901a\u5e38\u6709\u673a\u6eb6\u5242\u4ec5\u9700\u8981\u4f4e\u6e29\u84b8\u53d1\u4fbf\u80fd\u9664\u51fa\u53bb\u3002\u7136\u800c\uff0c\u914d\u65b9\u7814\u7a76\u4eba\u5458\u5728\u4f7f\u7528\u8fd9\u79cd\u65b9\u6cd5\u65f6\u9700\u8981\u9762\u4e34\u4e24\u4e2a\u4e3b\u8981\u6311\u6218\u3002\u5176\u4e00\u662f\uff0c\u5982\u679c\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u5177\u6709\u660e\u663e\u7684\u6781\u6027\u5dee\u5f02\uff0c\u4fbf\u5f88\u96be\u5c06\u5b83\u4eec\u6df7\u5408\u5728\u540c\u4e00\u79cd\u6eb6\u5242\u4e2d\u3002\u8868\u9762\u6d3b\u6027\u5242\u5e38\u5e38\u88ab\u7528\u4e8e\u63d0\u9ad8\u836f\u7269\u6216\u9ad8\u5206\u5b50\u6750\u6599\u5728\u7279\u5b9a\u6eb6\u5242\u4e2d\u7684\u6eb6\u89e3\u5ea6\u3002\u7136\u800c\uff0c\u5b83\u4eec\u5728\u6700\u7ec8\u914d\u65b9\u4e2d\u7684\u5242\u91cf\u5360\u6bd4\u5f80\u5f80\u4f1a\u5f88\u5927\uff0c\u8fd9\u5c31\u964d\u4f4e\u4e86\u836f\u7269\u7684\u8d1f\u8f7d\u80fd\u529b\uff0c\u800c\u5982\u679c\u5b83\u4eec\u5728\u4eba\u4f53\u5185\u7684\u8010\u53d7\u6027\u4e0d\u597d\uff0c\u4e5f\u53ef\u80fd\u4f1a\u5f15\u8d77\u95ee\u9898\u3002\u540c\u65f6\uff0c\u7531\u4e8e\u9700\u8981\u84b8\u53d1\u5927\u91cf\u7684\u6eb6\u5242\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u4e5f\u4f1a\u4ea7\u751f\u8f83\u9ad8\u7684\u6210\u672c\u3002\u7b2c\u4e8c\u4e2a\u6311\u6218\u662f\u5728\u53bb\u9664\u6eb6\u5242\u7684\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u53d1\u751f\u7684\u76f8\u5206\u79bb\u884c\u4e3a\u3002\u771f\u7a7a\u5e72\u71e5\u7684\u65b9\u6cd5\u5e38\u88ab\u7528\u4e8e\u53bb\u9664\u6eb6\u5242\uff0c\u5e76\u901a\u8fc7\u65cb\u8f6c\u84b8\u53d1\u5668\u5b9e\u73b0\u5feb\u901f\u5e72\u71e5\u3002\u4e3a\u4e86\u7f29\u77ed\u53ef\u80fd\u53d1\u751f\u76f8\u5206\u79bb\u7684\u65f6\u95f4\uff0c\u901a\u5e38\u4f1a\u9009\u62e9\u8f83\u9ad8\u7684\u5e72\u71e5\u6e29\u5ea6\u3002\u7136\u800c\uff0c\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u5728\u9ad8\u6e29\u4e0b\u7684\u5206\u5b50\u6d41\u52a8\u6027\u8f83\u9ad8\uff0c\u53ef\u80fd\u4f1a\u4fc3\u8fdb\u76f8\u5206\u79bb\u7684\u53d1\u751f<\/span>161<\/span><\/sup>\u3002<\/span><\/span><\/p>\n

\u55b7\u96fe\u5e72\u71e5\u6280\u672f\u5df2\u6210\u4e3a\u4e00\u79cd\u5236\u5907\u836f\u7269\u56fa\u4f53\u5206\u6563\u4f53\u7684\u6d41\u884c\u6280\u672f\u5de5\u827a<\/span><\/span><\/strong><\/span>162<\/span><\/sup>\u3002\u7528\u4e8e\u5c06\u6eb6\u6db2\u6216\u6df7\u60ac\u6db2\u4e00\u6b65\u8f6c\u5316\u4e3a\u5e72\u7c89\u3002\u8be5\u6280\u672f\u53ef\u4ee5\u5bf9\u5de5\u827a\u53d8\u91cf\u8fdb\u884c\u66f4\u597d\u7684\u64cd\u63a7\uff0c\u5236\u5907\u6240\u9700\u5c3a\u5bf8\u3001\u5f62\u72b6\u3001\u5bc6\u5ea6\u3001\u6d41\u52a8\u6027\u548c\u6676\u5f62\u7684\u7c89\u672b<\/span>163<\/span><\/sup>\u3002\u5728\u55b7\u96fe\u5e72\u71e5\u8fc7\u7a0b\u4e2d\uff0c\u6eb6\u5242\u7684\u84b8\u53d1\u901f\u5ea6\u975e\u5e38\u5feb\uff0c\u4f7f\u7c98\u5ea6\u7a81\u7136\u5347\u9ad8\uff0c\u5c06\u836f\u7269\u5206\u5b50\u622a\u7559\u5728\u9ad8\u5206\u5b50\u6750\u6599\u57fa\u8d28\u4e2d<\/span>164<\/span><\/sup>\u3002\u53ea\u8981\u80fd\u6eb6\u4e8e\u9002\u5408\u7684\u6eb6\u5242\uff0c\u4fbf\u53ef\u4ee5\u901a\u8fc7\u55b7\u96fe\u5e72\u71e5\u6280\u672f\u5c06\u6c34\u6eb6\u6027\u5dee\u7684\u836f\u7269\u5236\u6210\u975e\u5e38\u5c0f\u7684\u9897\u7c92\u3002\u5236\u5f97\u7684\u56fa\u4f53\u9897\u7c92\u7684\u6027\u8d28\u8fd8\u53d6\u51b3\u4e8e\u836f\u7269\u7684\u5316\u5b66\u6027\u8d28\uff0c\u55b7\u96fe\u5e72\u71e5\u53ef\u80fd\u4ea7\u751f\u975e\u6676\u4f53\u3001\u7ed3\u6676\u4f53\u3001\u4e0d\u5b8c\u5168\u6676\u4f53\u6216\u4e9a\u7a33\u6001\u6676\u4f53<\/span>165<\/span><\/sup>\u3002\u4e8b\u5b9e\u4e0a\uff0c<\/span>Mahlin<\/span>\u7b49\u4eba<\/span>166<\/span><\/sup>\u548c<\/span>Baird<\/span>\u7b49\u4eba<\/span>167<\/span><\/sup>\u5bf9\u4e0d\u540c\u7684\u836f\u7269\u6df7\u5408\u7269\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u5e76\u8868\u660e\u975e\u6676\u6001\u7684\u4ea7\u751f\u53d6\u51b3\u4e8e\u836f\u7269\u7684\u5316\u5b66\u6027\u8d28\u800c\u4e0d\u662f\u8fc7\u7a0b\u53d8\u91cf\uff0c\u800c\u5176\u7a33\u5b9a\u6027\u5219\u53d6\u51b3\u4e8e\u8fc7\u7a0b\u53d8\u91cf<\/span>168<\/span><\/sup>\u3002\u55b7\u96fe\u5e72\u71e5\u80fd\u591f\u5bf9\u7c89\u672b\u7279\u6027\u8fdb\u884c\u826f\u597d\u5730\u63a7\u5236\uff0c\u5e76\u4e14\u7531\u4e8e\u5176\u5236\u9020\u6210\u672c\u8f83\u4f4e\u3001\u6613\u4e8e\u653e\u5927\u548c\u8fde\u7eed\u6279\u91cf\u751f\u4ea7\uff0c\u5df2\u6210\u4e3a\u6700\u6d41\u884c\u7684\u6eb6\u5242\u5316\u751f\u4ea7\u65b9\u6cd5<\/span>169<\/span><\/sup>\u3002<\/span><\/span><\/p>\n

SCF<\/span>\u6cd5<\/span><\/span><\/strong><\/p>\n

SCFs<\/span>\u540c\u65f6\u5177\u6709\u6db2\u4f53\u548c\u6c14\u4f53\u7684\u7279\u6027\u3002\u5728\u8d85\u4e34\u754c\u6761\u4ef6\u4e0b\uff0c\u6d41\u4f53\u6750\u6599\u540c\u65f6\u5177\u6709\u7c7b\u4f3c\u4e8e\u6db2\u6001\u6eb6\u5242\u7684\u6027\u8d28\u548c\u6c14\u4f53\u7684\u7c98\u5ea6\u3001\u6269\u6563\u7cfb\u6570\u548c\u5bfc\u70ed\u6027\u80fd\u3002\u867d\u7136\u6eb6\u5242\u6027\u8d28\u6709\u5229\u4e8e\u63d0\u9ad8\u836f\u7269<\/span>\/<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u7684\u6eb6\u89e3\u5ea6\uff0c\u4f46\u5176\u7c7b\u4f3c\u4e8e\u6c14\u4f53\u7684\u6027\u8d28\u663e\u8457\u589e\u5f3a\u4e86\u6d41\u4f53\u7684\u4f20\u8d28\u7279\u6027\u3002\u8be5\u65b9\u6cd5\u4e3b\u8981\u4f7f\u7528\u8d85\u4e34\u754c\u4e8c\u6c27\u5316\u78b3\uff08<\/span>CO2<\/sub><\/span>\uff09\u4f5c\u4e3a\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u7684\u6eb6\u5242\u6216\u6297\u6eb6\u5242<\/span>170<\/span><\/sup>\u3002\u5c06\u9ad8\u5206\u5b50\u6750\u6599\u548c\u836f\u7269\u6eb6\u4e8e\u8d85\u4e34\u754c<\/span>CO2<\/sub><\/span>\u4e2d\uff0c\u901a\u8fc7\u55b7\u5634\u55b7\u5165\u4f4e\u538b\u533a\u57df\uff0c\u5f15\u53d1<\/span>CO2<\/sub><\/span>\u7edd\u70ed\u81a8\u80c0\u5e76\u8fc5\u901f\u51b7\u5374\u3002\u56e0\u6b64\uff0c\u8be5\u6280\u672f\u53ef\u4ee5\u6781\u5927\u5730\u964d\u4f4e\u836f\u7269\u7684\u7c92\u5f84\u3002\u8fd9\u88ab\u79f0\u4e3a\u8d85\u4e34\u754c\u6eb6\u6db2\u5feb\u901f\u81a8\u80c0\u6280\u672f\uff08<\/span>RESS<\/span>\uff09\u3002\u76ee\u524d\u7684<\/span>SCF<\/span>\u65b9\u6cd5\u5df2\u7ecf\u8bc1\u660e\u4e86\u5236\u9020\u76f4\u5f84\u4e3a<\/span>5- 2000 nm<\/span>\u7684\u7eb3\u7c73\u9897\u7c92\u60ac\u6d6e\u6db2\u7684\u53ef\u80fd<\/span>171<\/span><\/sup>\u3002\u7531\u4e8e\u8be5\u6280\u672f\u4e0d\u4f7f\u7528\u6709\u673a\u6eb6\u5242\uff0c\u800c\u4e14\u805a\u5408\u7269\u4e2d\u6b8b\u7559\u7684\u5c11\u91cf\u4e8c\u6c27\u5316\u78b3\u4e0d\u4f1a\u5bf9\u60a3\u8005\u9020\u6210\u5371\u5bb3\uff0c\u56e0\u6b64\u88ab\u8a89\u4e3a\u73af\u5883\u53cb\u597d\u578b\u6280\u672f\u3002\u6b64\u5916\uff0c\u8fd8\u53ef\u4ee5\u7ee7\u7eed\u5f00\u53d1<\/span>CO2<\/sub><\/span>\u4fc3\u4f7f\u9ad8\u5206\u5b50\u6750\u6599\u589e\u5851\u548c\u81a8\u80c0\u7684\u80fd\u529b\u3002\u4f46\u662f\uff0c\u5927\u591a\u6570\u836f\u7269\u5728<\/span>CO2<\/sub><\/span>\u4e2d\u7684\u6eb6\u89e3\u5ea6\u8f83\u4f4e\u9650\u5236\u4e86\u8be5\u65b9\u6cd5\u7684\u5b9e\u9645\u5e94\u7528<\/span>172<\/span><\/sup>\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u7f3a\u70b9\u5e76\u63d0\u9ad8\u6eb6\u89e3\u5ea6\uff0c\u73b0\u5df2\u5f00\u53d1\u4e86\u51e0\u79cd\u9002\u7528\u4e8e<\/span>SCF<\/span>\u7684\u5904\u7406\u65b9\u6cd5\u3002\u8fd9\u4e9b\u65b9\u6cd5\u5305\u62ec\u538b\u7f29\u53cd\u6eb6\u5242\u6c89\u6dc0\u6cd5<\/span>173<\/span><\/sup>\u3001\u5229\u7528<\/span>SCF<\/span>\u589e\u5f3a\u6eb6\u6db2\u5206\u6563<\/span>174<\/span><\/sup>\u3001\u8d85\u4e34\u754c\u53cd\u6eb6\u5242\u8fc7\u7a0b<\/span>175<\/span><\/sup>\u3001\u6c14\u4f53\u6297\u6eb6\u5242\u518d\u7ed3\u6676<\/span>176<\/span><\/sup>\u548c\u6c14\u6eb6\u80f6\u8d85\u4e34\u754c\u8403\u53d6\u7cfb\u7edf\u7b49<\/span>177<\/span><\/sup>\u3002<\/span><\/span><\/p>\n

<\/span><\/p>\n

\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a<\/p>\n

                            
<\/span><\/p>\n

\u56fe<\/span>10<\/span><\/span><\/strong> <\/span>\u56fa\u4f53\u5206\u6563\u4f53\u7684\u4e0d\u540c\u5236\u5907\u6280\u672f<\/span><\/span><\/p>\n

<\/span><\/span><\/p>\n

<\/mpcps><\/section>\n

PASDs<\/span><\/strong>\u7684\u7279\u5f81\u63cf\u8ff0<\/span><\/strong><\/span><\/p>\n

\u8003\u8651\u5230<\/span>ASDs\u7684\u81ea\u8eab\u6027\u8d28\u5e76\u4e14\u5b58\u5728\u518d\u7ed3\u6676\u7684\u5185\u5728\u98ce\u9669\uff0c\u9700\u8981\u5bf9\u8fd9\u4e9b\u914d\u65b9\u8fdb\u884c\u6df1\u5165\u7684\u7279\u5f81\u63cf\u8ff0\u3002\u57fa\u4e8e\u8d28\u91cf\u8bbe\u8ba1\u539f\u5219\uff0c\u8981\u6c42\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u900f\u5f7b\u7684\u4e86\u89e3\u5168\u90e8\u8fc7\u7a0b\u3002\u6ca1\u6709\u54ea\u4e00\u79cd\u5355\u72ec\u7684\u8868\u5f81\u6280\u672f\u53ef\u4ee5\u63cf\u8ff0\u51fa\u5176\u5168\u8c8c\uff0c\u901a\u5e38\u9700\u8981\u4e00\u6574\u5957\u65b9\u6cd5\u8fdb\u884c\u76f8\u4e92\u8865\u5145\uff08\u56fe<\/span>11\uff09\u3002\u4e0b\u9762\u5c06\u5bf9\u73b0\u6709\u6587\u732e\u8fdb\u884c\u7b80\u8981\u7684\u9009\u62e9\u6027\u8ba8\u8bba\u3002<\/span><\/span><\/p>\n

X-<\/span>\u5c04\u7ebf\u7c89\u672b\u884d\u5c04<\/span><\/span><\/strong><\/p>\n

X<\/span>\u5c04\u7ebf\u7c89\u672b\u884d\u5c04\u662f\u8868\u5f81\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\u7684\u91cd\u8981\u6280\u672f\u624b\u6bb5<\/span>178<\/span><\/sup>\u3002<\/span>Moes<\/span>\u7b49\u4eba<\/span>179<\/span><\/sup>\uff0c<\/span>Zhao<\/span>\u7b49\u4eba<\/span>180<\/span><\/sup>\u548c<\/span>Al-Obaidi<\/span>\u7b49\u4eba<\/span>181<\/span><\/sup>\u62a5\u9053\u4e86\u4f7f\u7528\u8fd9\u79cd\u6280\u672f\u6765\u786e\u5b9a\u56fa\u4f53\u5206\u6563\u4f53\u4e2d\u975e\u6676\u6001\u836f\u7269\u7684\u5b58\u5728\u3002<\/span>X<\/span>\u5c04\u7ebf\u7c89\u672b\u884d\u5c04\u4eea\uff08<\/span>XRPD<\/span>\uff09\u548c\u8f6f\u4ef6\u53ef\u4ee5\u5728\u6263\u9664\u80cc\u666f\u7684\u6761\u4ef6\u4e0b\u63d0\u4f9b\u6709\u7528\u7684\u6570\u636e\u4fe1\u606f\uff0c\u4f8b\u5982\u901a\u8fc7\u914d\u5907\u53ef\u53d8\u6e29\uff08<\/span>VT<\/span>\uff09\u6216\u6e7f\u5ea6\u63a7\u5236\u7cfb\u7edf\u7684<\/span>XRPD<\/span>\uff0c\u53ef\u4ee5\u6df1\u5165\u4e86\u89e3\u56fa\u4f53\u5206\u6563\u4f53\u4e2d\u975e\u6676\u6001\u836f\u7269\u5728\u5e94\u529b\u6761\u4ef6\u4e0b\u7684\u5206\u5b50\u884c\u4e3a<\/span>182<\/span><\/sup>\u3002<\/span>Zhu<\/span>\u7b49\u4eba<\/span>183<\/span><\/sup>\u5df2\u7ecf\u901a\u8fc7\u540c\u6b65\u8f90\u5c04\u5c0f\u89d2\u5ea6<\/span>X<\/span>\u5c04\u7ebf\u6563\u5c04<\/span>\/<\/span>\u5e7f\u89d2<\/span>X<\/span>\u5c04\u7ebf\u6563\u5c04\u6280\u672f\u5f00\u5c55\u4e86\u8418\u666e\u751f\u56fa\u4f53\u5206\u6563\u4f53\u5728\u4e0d\u540c\u6e29\u5ea6\u4e0b\u7684\u7ed3\u6676\u52a8\u529b\u5b66\u7814\u7a76\u3002\u6b64\u5916\uff0c\u539f\u5b50\u6210\u5bf9\u5206\u5e03\u51fd\u6570\u5728\u68c0\u6d4b\u836f\u7269\u7531\u975e\u6676\u6001\u5411\u7ed3\u6676\u4f53\u72b6\u6001\u7684\u8bf1\u5bfc\u7a0b\u5ea6\u65b9\u9762\u5177\u6709\u91cd\u8981\u610f\u4e49<\/span>184<\/span><\/sup>\u3002<\/span>Nollenberger<\/span>\u7b49\u4eba<\/span>185<\/span><\/sup>\u5df2\u7ecf\u4f7f\u7528\u6210\u5bf9\u5206\u5e03\u51fd\u6570\u5206\u6790\u663e\u793a\uff0c\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u9ad8\u5206\u5b50\u6750\u6599\u7ed3\u6784\u7684\u7ec6\u5fae\u53d8\u5316\u5bf9\u6700\u7ec8\u4ea7\u7269<\/span><\/span>\u7684\u91ca\u653e\u7279\u6027\u6709\u7740\u663e\u8457\u5f71\u54cd\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a<\/p>\n

\u56fe<\/span>11<\/span><\/span><\/strong> <\/span>\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\u7684\u56fa\u6001\u8868\u5f81\u5de5\u5177\u3002<\/span>SAXS<\/span>\uff0c\u5c0f\u89d2\u5ea6<\/span>X<\/span>\u5c04\u7ebf\u6563\u5c04\uff1b<\/span>WAXS<\/span>\uff0c\u5e7f\u89d2<\/span>X<\/span>\u5c04\u7ebf\u6563\u5c04\uff1b<\/span>PDF<\/span>\uff0c<\/span><\/span>\u6210\u5bf9\u5206\u5e03\u51fd\u6570<\/span>\uff1b<\/span>DVS<\/span>\uff0c\u52a8\u6001\u84b8\u6c14\u5438\u9644\uff1b<\/span>XRPD<\/span>\uff0c<\/span>X<\/span>\u5c04\u7ebf\u7c89\u672b\u884d\u5c04\uff1b<\/span>ssNMR<\/span>\uff0c\u56fa\u6001\u6838\u78c1\u5171\u632f\u6280\u672f\uff1b<\/span>XRD<\/span>\uff0c<\/span>X<\/span>\u5c04\u7ebf\u884d\u5c04\u3002<\/span><\/span><\/p>\n

\u70ed\u5206\u6790<\/span><\/strong><\/p>\n

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\u968f\u7740\u8fc7\u53bb\u51e0\u5e74\u66f4\u52a0\u7cbe\u5bc6\u4eea\u5668\u7684\u76f8\u7ee7\u51fa\u73b0\uff0c\u73b0\u5728\u53ef\u4ee5\u6839\u636e\u6e29\u5ea6\u7684\u53d8\u5316\u8fdb\u884c\u5b9e\u65f6\u56fa\u6001\u7279\u6027\u5206\u6790\u3002\u5229\u7528<\/span>VT\u5206\u5b50\u5149\u8c31\u3001<\/span>VT-XRPD\u548c<\/span>VT-ssNMR\u7b49\u6280\u672f\uff0c\u53ef\u4ee5\u66f4\u8be6\u7ec6\u5730\u5bf9\u56fa\u4f53\u5206\u6563\u4f53\u4e2d\u975e\u6676\u6001\u836f\u7269\u7684\u5206\u5b50\u53d6\u5411\u548c\u7ed3\u6784\u5f1b\u8c6b\u53ca\u5176\u4e0e\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u8fdb\u884c\u7814\u7a76\u3002<\/span>Nano-TA\u662f\u4e00\u79cd\u9488\u5bf9\u5c40\u57df\u6027\u7684<\/span>TA\u6280\u672f\uff0c\u5f53\u4e0e\u539f\u5b50\u529b\u663e\u5fae\u6280\u672f\u7ed3\u5408\u65f6\uff0c\u53ef\u4ee5\u83b7\u5f97\u975e\u6676\u6001\u836f\u7269\u70ed\u884c\u4e3a\u7684\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002\u5728\u4ee5<\/span>Nano-TA\u6280\u672f\u4e3a\u57fa\u7840\u7684\u539f\u5b50\u529b\u663e\u5fae\u955c\u7684\u5fae\u578b\u7845\u57fa\u63a2\u9488\u9876\u90e8\uff0c\u653e\u7f6e\u4e86\u4e00\u4e2a\u7a7a\u95f4\u5206\u8fa8\u7387\u7ea6\u4e3a<\/span>5 nm\u7684\u5fae\u578b\u52a0\u70ed\u5668\uff0c\u4ece\u800c\u80fd\u591f\u6d4b\u91cf\u7eb3\u7c73\u7ea7\u522b\u7684\u70ed\u6027\u80fd\u53c2\u6570<\/span>190<\/sup>\u3002<\/span><\/span><\/p>\n

\u5149\u8c31\u5b66<\/span><\/p>\n

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\u6c34\u84b8\u6c14\u5438\u9644<\/span><\/strong><\/p>\n

\u6c34\u84b8\u6c14\u5438\u9644\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u975e\u6676\u6001\u548c\u7ed3\u6676\u6001\u7269\u8d28\u5728\u6c34\u5206\u5b58\u5728\u4e0b\u7684\u884c\u4e3a\u7814\u7a76\u3002\u8bf8\u5982\u9884\u6d4b\u5355\u4e2a\u7ec4\u5206\u5438\u6e7f\u7b49\u6e29\u7ebf\u7684\u52a0\u548c\u6027\u6216\u4f7f\u7528\u4e09\u5143<\/span>FH\u76f8\u4e92\u4f5c\u7528\u7b49\u7406\u8bba\u5206\u6790\u65b9\u6cd5\u5bf9\u5438\u6e7f\u6570\u636e\u8fdb\u884c\u89e3\u91ca\uff0c\u5e76\u4ee5\u6b64\u9610\u8ff0\u836f\u7269<\/span>–\u9ad8\u5206\u5b50\u6750\u6599<\/span>–\u6c34\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/span>199<\/sup>\u3002\u5f53\u4e0e<\/span>DSC\u3001\u5085\u91cc\u53f6\u53d8\u6362\u7ea2\u5916\u5149\u8c31\u548c\u6838\u78c1\u5171\u632f<\/span>(NMR)\u7b49\u5176\u5b83\u6280\u672f\u7ed3\u5408\u4f7f\u7528\u65f6\uff0c\u53ef\u63d0\u4f9b\u5404\u79cd\u5206\u5b50\u6c34\u5e73\u7684\u5c5e\u6027\u4fe1\u606f\uff0c\u5982\u8868\u9762\u6027\u8d28\u3001\u975e\u6676\u5316\u7a0b\u5ea6\u3001\u76f8\u8f6c\u53d8\u3001\u73bb\u7483\u5316\u8f6c\u53d8\u548c\u7ed3\u6676\u6001\u7684\u4e34\u754c\u76f8\u5bf9\u6e7f\u5ea6\uff0c\u4ee5\u53ca\u65b0\u5236\u5907\u548c\u8001\u5316\u6750\u6599\u7684\u7269\u7406\u7a33\u5b9a\u6027<\/span>200-202<\/sup>\u3002\u52a8\u6001\u6c34\u84b8\u6c14\u5438\u9644\u7ed3\u5408\u8fd1\u7ea2\u5916\u5149\u8c31\u6280\u672f\uff0c\u53ef\u4ee5\u6839\u636e\u6e29\u5ea6\u548c\u76f8\u5bf9\u6e7f\u5ea6\u6765\u5224\u65ad\u975e\u6676\u6001\u6750\u6599\u5728\u7ed3\u6676\u524d\u548c\u7ed3\u6676\u8fc7\u7a0b\u4e2d\u7684\u89e3\u5438\u9644\u884c\u4e3a<\/span>203<\/sup>\u3002<\/span><\/span><\/p>\n

\u56fa\u4f53\u6838\u78c1\u5171\u632f<\/span><\/strong><\/p>\n

ssNMR<\/span>\u662f\u4e00\u79cd\u65e0\u635f\u6280\u672f\uff0c\u53ef\u4ee5\u63d0\u4f9b\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\u7684\u5b9a\u6027\u548c\u5b9a\u91cf\u4fe1\u606f\u3002\u5b83\u96c6<\/span>NMR<\/span>\u5f1b\u8c6b\u65f6\u95f4<\/span>\/<\/span>\u5149\u8c31\u5b66<\/span>\/<\/span>\u6210\u50cf\u6280\u672f\u4e8e\u4e00\u4f53\uff0c\u5bf9\u7269\u8d28\u7684\u4e00\u7ef4\u548c\u4e8c\u7ef4\u7ed3\u6784\u4fe1\u606f\u8fdb\u884c\u4e86\u8be6\u7ec6\u63cf\u8ff0<\/span>204<\/span><\/sup>\u3002\u901a\u8fc7\u5c06\u5f1b\u8c6b\u65f6\u95f4\u4e0e\u81ea\u65cb\u6269\u6563\u7684\u7a7a\u95f4\u5c3a\u5ea6\u76f8\u5173\u8054\uff0c\u53ef\u4ee5\u9884\u6d4b\u56fa\u4f53\u5206\u6563\u4f53\u4e2d\u7684\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u7684\u7a7a\u95f4\u7ed3\u6784\u5927\u5c0f\u3002\u4f8b\u5982\uff0c<\/span>T1<\/span>\u8303\u56f4\u5728<\/span>1<\/span>\u548c<\/span>5 s<\/span>\u4e4b\u95f4\u7684\u81ea\u65cb\u6676\u683c\u5f1b\u8c6b\u65f6\u95f4\uff0c\u76f8\u5f53\u4e8e\u5927\u7ea6<\/span>20-50 nm<\/span>\u7684\u8ddd\u79bb\u3002\u53e6\u5916\uff0c<\/span>5<\/span>\u5230<\/span>50 ms<\/span>\u4e4b\u95f4\u7684<\/span>T1\u03c1<\/sub><\/span>\uff08\u81ea\u65cb<\/span>–<\/span>\u81ea\u65cb\u5f1b\u8c6b\u65f6\u95f4\uff09\u503c\u4ee3\u8868\u5927\u7ea6<\/span>2-5 nm<\/span>\u7684\u8ddd\u79bb\u3002\u53ef\u4ee5\u6839\u636e\u8fd9\u4e9b\u5f1b\u8c6b\u65f6\u95f4\u7684\u6d4b\u91cf\u7ed3\u679c\u8fdb\u884c\u53ef\u9760\u9884\u6d4b\u3002\u4ece\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\u4e2d\u6d4b\u5f97\u7684<\/span>1<\/span><\/sup>H T1<\/sub><\/span>\u548c<\/span>T1\u03c1<\/sub><\/span>\u503c\u8868\u793a\u8be5\u533a\u57df\u7684\u957f\u5ea6\u8303\u56f4\u5c0f\u4e8e<\/span>2-5 nm<\/span>\u3002<\/span>T1\u03c1<\/sub><\/span>\u503c\u4e0d\u540c\uff0c\u4f46<\/span>T1<\/sub><\/span>\u503c\u76f8\u540c\u8868\u660e\u8be5\u533a\u57df\u957f\u5ea6\u8303\u56f4\u7ea6\u4e3a<\/span>5-20 nm<\/span>\u3002\u5f53\u836f\u7269\u548c\u9ad8\u5206\u5b50\u6750\u6599\u5c3a\u5bf8\u5927\u4e8e<\/span>20-50 nm<\/span>\u65f6\u5c06\u88ab\u8d4b\u4e88\u4e0d\u540c\u7684<\/span>T1<\/sub><\/span>\u548c<\/span>T1\u03c1<\/sub><\/span>\u503c\u3002\u4e0e\u5177\u6709\u5927\u7ea6<\/span>20-30 nm<\/span>\u7075\u654f\u5ea6\u7684<\/span>DSC<\/span>\u6cd5\u76f8\u6bd4\uff0c\u8be5\u65b9\u6cd5\u7075\u654f\u5ea6\u66f4\u9ad8\uff0c\u5e76\u4e14\u5f53\u533a\u57df\u5c3a\u5bf8\u5c0f\u4e8e\u6b64\u503c\u65f6\u5c06\u5f97\u5230\u65b0\u7684<\/span>Tg<\/span>\u503c\u3002\u56e0\u6b64\uff0c<\/span>ssNMR<\/span>\u5f1b\u8c6b\u6d4b\u5b9a\u6cd5\u5c06\u6709\u52a9\u4e8e\u66f4\u597d\u5730\u4e86\u89e3\u56fa\u4f53\u5206\u6563\u4f53\u4e2d\u836f\u7269<\/span>–<\/span>\u9ad8\u5206\u5b50\u6750\u6599\u4e4b\u95f4\u7684\u7d27\u5bc6\u5173\u7cfb\uff0c\u8fd9\u6709\u52a9\u4e8e\u63d0\u9ad8\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\u7684\u7a33\u5b9a\u6027\uff0c\u5e76\u907f\u514d\u5728\u4ea7\u54c1\u4fdd\u8d28\u671f\u5185\u51fa\u73b0\u76f8\u5206\u79bb<\/span>205<\/span><\/sup>\u3002\u901a\u8fc7\u6d4b\u91cf<\/span>1<\/span><\/sup>H<\/span>\u6a2a\u5411\u78c1\u5316\u5f1b\u8c6b\u65f6\u95f4<\/span>T2<\/sub><\/span>\uff0c\u53ef\u4ee5\u83b7\u5f97\u9ad8\u5206\u5b50\u6750\u6599\u5728\u56fa\u4f53\u5206\u6563\u4f53\u4e2d\u7684\u76f8\u5185\u7ec4\u6210\u548c\u5206\u5b50\u6d41\u52a8\u6027\u7684\u76f8\u5173\u4fe1\u606f<\/span>206<\/span><\/sup>\u3002\u901a\u8fc7<\/span>13<\/span><\/sup>C<\/span>\u4ea4\u53c9\u6781\u5316\u9b54\u89d2\u65cb\u8f6c<\/span>NMR<\/span>\u5206\u6790\u5b9e\u9a8c\uff0c\u8003\u5bdf\u4e86\u5e94\u7528\u4e0d\u540c\u5236\u5907\u65b9\u6cd5\u5f97\u5230\u7684\u975e\u6676\u6001\u66f2\u683c\u5217\u916e\u56fa\u4f53\u5206\u6563\u4f53\u7684\u518d\u7ed3\u6676\u60c5\u51b5\uff0c\u4e0e\u5728<\/span>XRPD<\/span>\u6a21\u5f0f\u4e0b\u5e76\u65e0\u5dee\u522b<\/span>207<\/span><\/sup>\u3002<\/span>NMR<\/span>\u663e\u5fae\u6210\u50cf\u6280\u672f\u662f\u5bf9\u6eb6\u5242\u6269\u6563\u548c\u9ad8\u5206\u5b50\u6750\u6599\u6d3b\u5316\u52a8\u529b\u5b66\u5206\u6790\u7814\u7a76\u65b9\u6cd5\u7684\u91cd\u8981\u8865\u5145<\/span>208<\/span><\/sup>\u3002<\/span><\/span><\/p>\n

\u53cd\u76f8\u6c14\u76f8\u8272\u8c31<\/span><\/strong><\/p>\n

\u53cd\u76f8\u6c14\u76f8\u8272\u8c31\u6cd5\u662f\u4e00\u79cd\u65b0\u5174\u6280\u672f\uff0c\u88ab\u7528\u4e8e\u5206\u6790\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\u7684\u8868\u9762\u6027\u8d28<\/span>209<\/sup>\u3002\u7528\u4e8e\u68c0\u6d4b\u5206\u5b50\u7684\u6d41\u52a8\u6027\u3001\u975e\u6676\u6001\u8f6c\u53d8\u3001\u518d\u7ed3\u6676\u6216\u5206\u5b50\u5f1b\u8c6b\uff0c\u5e76\u7279\u522b\u9002\u7528\u4e8e\u68c0\u6d4b\u5e94\u7528\u76f8\u540c\u6216\u4e0d\u540c\u65b9\u6cd5\u5236\u5907\u7684\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\u7684\u4e0d\u540c\u6279\u6b21\u53d8\u5316<\/span>210<\/sup>\u3002\u6b64\u5916\uff0c\u9488\u5bf9\u6750\u6599\u8868\u9762\u7684\u5206\u5b50\u6d41\u52a8\u6027\u9ad8\u4e8e\u5176\u5185\u90e8\u7684\u7814\u7a76\uff0c\u5c06\u6709\u52a9\u4e8e\u5bf9\u975e\u6676\u6001\u836f\u7269\u6c34\u5206\u76f8\u4e92\u4f5c\u7528\u548c\u518d\u7ed3\u6676\u8fc7\u7a0b\u8fdb\u884c\u4e86\u89e3<\/span>211<\/sup>\u3002<\/span>Hasegawa\u7b49\u4eba<\/span>212<\/sup>\u5229\u7528\u53cd\u5411\u6c14\u76f8\u8272\u8c31\u6cd5\u7814\u7a76\u56fa\u4f53\u5206\u6563\u4f53\u8868\u9762\u7684\u7ed3\u6784\u5f1b\u8c6b\uff0c\u53d1\u73b0\u7531\u4e8e\u8868\u9762\u5206\u5b50\u6d41\u52a8\u6027\u8f83\u9ad8\uff0c\u53d1\u751f\u5728\u8868\u9762\u7684\u7ed3\u6784\u5f1b\u8c6b\u901f\u5ea6\u8981\u9ad8\u4e8e\u5176\u5185\u90e8\u3002\u901a\u8fc7\u5bf9\u56fa\u4f53\u5206\u6563\u4f53\u8868\u9762\u7684\u7ed3\u6676\u52a8\u529b\u5b66\u7814\u7a76\uff0c\u53ef\u4ee5\u9884\u6d4b\u5206\u6790\u975e\u6676\u6001\u7269\u8d28\u7684\u7269\u7406\u7a33\u5b9a\u6027<\/span>213<\/sup>\u3002<\/span><\/span><\/p>\n

PASDs<\/span><\/strong>\u7684\u6eb6\u51fa\u884c\u4e3a<\/span><\/strong><\/span><\/p>\n

\u6eb6\u51fa\u8bd5\u9a8c\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u9884\u6d4b\u914d\u65b9\u5728\u4f53\u5185\u7684\u6027\u80fd\u53c2\u6570\u3002\u7136\u800c\uff0c\u901a\u8fc7\u6eb6\u89e3\u52a8\u529b\u5b66\u53c2\u6570\u65e0\u6cd5\u9884\u6d4b\u751f\u6210\u548c\u7ef4\u6301\u8fc7\u9971\u548c\u72b6\u6001\u7684\u590d\u6742\u6027<\/span>(\u56fe<\/span>12)\uff0c\u5e76\u4e14\u65e0\u6cd5\u5168\u9762\u4f53\u73b0\u8fd9\u79cd\u836f\u7269\u91ca\u653e\u7cfb\u7edf\u7684\u589e\u6eb6\u4f5c\u7528\u5bf9\u5438\u6536\u8fc7\u7a0b\u7684\u4fc3\u8fdb\u6548\u679c\uff0c\u56e0\u6b64\uff0c\u5efa\u7acb\u4e00\u79cd\u7cbe\u786e\u7684\u4f53\u5185<\/span>–\u4f53\u5916\u76f8\u5173\u6027\u5173\u7cfb\u5c06\u975e\u5e38\u5177\u6709\u6311\u6218\u6027<\/span>214<\/sup>\u3002\u4f46\u8fd9\u9002\u7528\u4e8e<\/span>PASDs\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u4e0d\u540c\u7684\u590d\u6742\u8fc7\u7a0b\u5c06\u5728\u5176\u6eb6\u89e3\u8fc7\u7a0b\u4e2d\u540c\u65f6\u53d1\u751f<\/span>215<\/sup>\u3002<\/span><\/span><\/p>\n

\"\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\uff1a<\/p>\n

<\/span><\/p>\n

\u56fe<\/span>12<\/span>\u9ad8\u5206\u5b50\u975e\u6676\u6001\u56fa\u4f53\u5206\u6563\u4f53\u7684\u6eb6\u89e3\u884c\u4e3a\u3002<\/span>(a)<\/span>\u7b2c\u4e00\u79cd\u60c5\u51b5\uff1b<\/span>(b)<\/span>\u7b2c\u4e8c\u79cd\u60c5\u51b5\uff1b<\/span>(c)<\/span>\u7b2c\u4e09\u79cd\u60c5\u51b5\u3002<\/span><\/p>\n

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\u7ed3\u8bba<\/span><\/strong><\/span><\/p>\n

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\u81f4\u8c22<\/span><\/strong><\/span><\/p>\n

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<\/p>\n

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<\/strong>
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\n

\u6295\u7a3f\u8bf7\u8054\u7cfb\u7fa4\u4e3b\uff08\u90ae\u7bb1\uff1a9111628@qq.com\uff09\u6216\u5fae\u4fe1\u7f16\u8f91\uff081642214@qq.com\uff09\u3002<\/span>
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\u2014\u2014\u7814\u5982\u7389\u2014\u2014<\/span><\/p>\n


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\u836f\u7814\u4eba\u7684\u7f51\u4e0a\u5bb6\u56ed<\/span>
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<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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