{"id":56932,"date":"2018-09-28T01:00:00","date_gmt":"2018-09-30T02:20:57","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e7%94%9f%e7%89%a9%e5%a4%a7%e5%88%86%e5%ad%90%e8%8d%af%e7%89%a9%e4%bb%a3%e8%b0%a2%e6%b6%88%e9%99%a4%e9%80%94%e5%be%84%e5%8f%8a%e4%bd%93%e5%a4%96%e4%bb%a3%e8%b0%a2%e7%a0%94%e7%a9%b6%e6%96%b9%e6%b3%95\/"},"modified":"2018-09-30T10:20:59","modified_gmt":"2018-09-30T02:20:59","slug":"%e7%94%9f%e7%89%a9%e5%a4%a7%e5%88%86%e5%ad%90%e8%8d%af%e7%89%a9%e4%bb%a3%e8%b0%a2%e6%b6%88%e9%99%a4%e9%80%94%e5%be%84%e5%8f%8a%e4%bd%93%e5%a4%96%e4%bb%a3%e8%b0%a2%e7%a0%94%e7%a9%b6%e6%96%b9%e6%b3%95","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/56932\/","title":{"rendered":"\u751f\u7269\u5927\u5206\u5b50\u836f\u7269\u4ee3\u8c22\u6d88\u9664\u9014\u5f84\u53ca\u4f53\u5916\u4ee3\u8c22\u7814\u7a76\u65b9\u6cd5\u8fdb\u5c55"},"content":{"rendered":"
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1.1 \u80be\u5c0f\u7403\u6ee4\u8fc7<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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1.2 \u9176\u6c34\u89e3\u4ee3\u8c22<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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GLP-1 \u5929\u7136\u7c7b\u4f3c\u7269\u827e\u585e<\/span>\u90a3\u80bd\uff08Exendin-4\uff09\u4e0d\u6613\u88abDPPIV \u964d\u89e3\uff0c\u7a33\u5b9a\u6027\u6709\u6240\u6539\u5584\uff0c\u534a\u8870<\/span>\u671f\u4e3a2.5 h\uff0c\u6210\u4e3a\u9996\u4e2a\u83b7\u6279\u7684GLP-1 \u7c7b\u4f3c\u7269\u3002\u6b64\u5916\uff0c\u65b0\u578bGLP-1<\/span>\u7c7b\u4f3c\u7269\u7d22\u739b\u9c81\u6cf0\u901a\u8fc7\u5bf9\u6c28\u57fa\u9178\u5e8f\u5217\u4f18\u5316\uff0c\u589e\u52a0\u4e86\u5176\u5bf9DPPIV<\/span>\u7684\u7a33\u5b9a\u6027\uff0c\u534a\u8870\u671f\u5ef6\u957f\u81f3168 h\uff0c\u5927\u5927\u589e\u52a0\u4e86\u60a3\u8005\u4f9d\u4ece\u6027\u3002<\/span><\/p>\n

\u8f6c<\/span>\u79fb\u6291\u7d20\u662f\u753154 \u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\u7684\u591a\u80bd\uff0c \u5176\u622a\u65ad\u578b\u8f6c\u79fb\u6291\u7d20<\/span>\uff0845~54\uff09\u4f53\u5916\u6d3b\u6027\u662f\u539f\u578b\u8f6c\u79fb\u6291\u7d20\u76843~10 \u500d\uff0c\u4f46\u8fd9\u4e24\u79cd\u591a\u80bd<\/span>\u90fd\u5bf9\u4ee3\u8c22\u9176\u654f\u611f\uff0c\u53ef\u5728\u5c0f\u9f20\u8840\u6d46\u4e2d\u88ab\u8fc5\u901f\u4ee3\u8c22\u3002<\/span><\/p>\n

ASAMI \u7b49\u901a<\/span>\u8fc7\u5bf9\u8f6c\u79fb\u6291\u7d20\u6539\u6784\uff0c\u5927\u5927\u63d0\u9ad8\u4e86\u5176\u4ee3\u8c22\u7a33\u5b9a\u6027\uff0c\u6539\u6784\u540e\u7684\u5206<\/span>\u5b50\u5bf9\u80f0\u51dd\u4e73\u86cb\u767d\u9176\u3001\u8111\u5561\u80bd\u9176\u548c\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u91769 \u7b49\u8840\u6d46\u86cb<\/span>\u767d\u9176\u5177\u6709\u6297\u6027\u3002<\/span>\u5e94\u7528\u52a8\u529b\u5b66\u6a21\u578b\u5206\u6790\u6539\u6784\u540e\u7684\u7c7b\u4f3c\u7269\u5728\u4eba\u8840<\/span>\u6e05\u4e2d\u7684\u534a\u8870\u671f\uff0c\u7ed3\u679c\u8868\u660e\u534a\u8870\u671f\u5927\u5927\u5ef6\u957f\u3002<\/span><\/p>\n

\u5728\u751f\u7269\u836f\u7269\u7814\u53d1<\/span>\u65e9\u671f\uff0c\u8003\u8651\u9176\u6c34\u89e3\u9020\u6210\u7684\u80bd\u548c\u86cb\u767d\u8d28\u964d\u89e3\u5bf9\u5206\u5b50\u4ee3\u8c22\u6027\u8d28\u7684<\/span>\u5f71\u54cd\uff0c \u5e76\u901a\u8fc7\u7ed9\u4e88\u9176\u6291\u5236\u5242\u6216\u5bf9\u6c34\u89e3\u9176\u6613\u611f\u90e8\u4f4d\u8fdb\u884c\u6539\u6784\uff0c<\/span>\u53ef\u4ee5\u5ef6\u957f\u5176\u534a\u8870\u671f\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
<\/span> <\/span> <\/section>\n
\n

1.3 \u53d7\u4f53\u4ecb\u5bfc\u7684\u80de\u541e\u6d88\u9664<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u53c2\u4e0e\u7ec6\u80de\u5185\u541e\u4f5c\u7528\u7684\u53d7\u4f53\u5305\u62ec\u5927\u5206\u5b50\u836f\u7269\u7684\u9776\u53d7\u4f53\u4ee5\u53ca\u9664\u9776\u53d7\u4f53\u4ee5\u5916\u7684\u6d88\u9664\u578b\u53d7\u4f53\uff0c\u540e\u8005\u5305\u542b\u7cd6\u86cb\u767d\u53d7\u4f53\u3001Fc \u53d7<\/span>\u4f53\u548cFcRn \u53d7\u4f53\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n
\n

1.3.1 \u9776\u53d7\u4f53\u4ecb\u5bfc\u7684\u6d88\u9664<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u86cb\u767d\u8d28\u836f\u7269\u9776\u70b9\u660e\u786e\uff0c \u7279\u5f02\u6027\u9ad8\uff0c\u5176\u53d1\u6325\u836f\u6548\u4f1a\u9009\u62e9\u6027\u7684\u4f5c\u7528\u4e8e\u5176\u4e13\u4e00\u6027\u9776\u70b9\uff0c\u5373\u9776\u53d7\u4f53\u3002<\/span><\/p>\n

\u9776\u53d7\u4f53\u4e0e\u86cb\u767d\u8d28\u836f\u7269\u7ed3\u5408\u540e\uff0c\u901a\u5e38\u4f1a\u643a\u5e26\u5df2\u7ecf\u7ed3\u5408\u7684\u86cb\u767d\u8d28\u836f\u7269\u5185\u5316\u8fdb\u5165\u7ec6\u80de\uff0c \u5e76\u4ecb\u5bfc\u86cb\u767d\u8d28\u836f\u7269\u7684\u80de\u5185\u964d\u89e3\u8fc7\u7a0b\u3002\u56e0<\/span>\u6b64\uff0c\u9776\u53d7\u4f53\u7684\u4f5c\u7528\u4e0d\u4ec5\u4e0e\u5176\u836f\u6548\u5b66\u7d27\u5bc6\u76f8\u5173\uff0c\u540c\u65f6\u4e5f\u4f1a\u663e\u8457<\/span>\u5f71\u54cd\u86cb\u767d\u8d28\u836f\u7269\u6d88\u9664\u8fc7\u7a0b\u3002<\/span><\/p>\n

\u9776\u53d7\u4f53\u4ecb\u5bfc\u7684\u6d88\u9664\u4f5c\u7528\u7684\u5927\u5c0f\u53d6<\/span>\u51b3\u4e8e\u86cb\u767d\u8d28\u5bf9\u5176\u9776\u53d7\u4f53\u7684\u4eb2\u548c\u529b\u3001\u9776\u53d7\u4f53\u8868\u8fbe\u6c34\u5e73\u3001\u9776\u53d7\u4f53<\/span>\u7684\u5185\u5316\u7387\u4ee5\u53ca\u6cbb\u7597\u6027\u86cb\u767d\u8d28\u7684\u7ed9\u836f\u6d53\u5ea6\u548c\u9776\u7ec6\u80de\u5185\u7684\u5206\u89e3<\/span>\u4ee3\u8c22\u901f\u7387\u3002<\/span><\/p>\n

\u901a\u5e38\u60c5\u51b5\u4e0b\uff0c\u5f53\u6cbb\u7597\u836f\u7269\u6d53\u5ea6\u4f4e\uff0c\u9776\u53d7\u4f53\u6d53\u5ea6\u548c<\/span>\u5185\u5316\u7387\u9ad8\u65f6\uff0c \u4e14\u86cb\u767d\u8d28\u6cbb\u7597\u5242\u4e0e\u9776\u53d7\u4f53\u95f4\u7684\u4eb2\u548c\u529b\u975e\u5e38\u9ad8<\/span>\u65f6\uff0c\u9776\u53d7\u4f53\u4ecb\u5bfc\u7684\u6d88\u9664\u4f5c\u7528\u66f4\u663e\u8457\u3002\u53e6\u5916\uff0c\u9776\u53d7\u4f53\u4ecb\u5bfc\u7684\u6d88\u9664<\/span>\u4e0d\u4ec5\u53d1\u751f\u4e8e\u8868\u8fbe\u5728\u7ec6\u80de\u819c\u8868\u9762\u7684\u9776\u53d7\u4f53\uff0c\u4e5f\u53d1\u751f\u5728\u53ef\u6eb6\u6027\u53d7<\/span>\u4f53\u3002\u5e76\u4e14\u4e0e\u7ec4\u7ec7\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684\u9776\u53d7\u4f53\u76f8\u6bd4\uff0c\u5728\u8840\u6db2\u4e2d\u8868\u8fbe\u7684<\/span>\u9776\u53d7\u4f53\u4e00\u822c\u5bf9\u86cb\u767d\u8d28\u836f\u7269\u6d88\u9664\u7684\u5f71\u54cd\u66f4\u663e\u7740\u3002<\/span><\/p>\n

\u53ef\u6eb6\u6027\u9776\u53d7\u4f53<\/span>\u4e0e\u4e24\u4e2a\u6216\u591a\u4e2a\u6297\u4f53\u7ed3\u5408\u53ef\u5bfc\u81f4\u541e\u566c\u4f5c\u7528\u5e76\u4ecb\u5bfcmAb \u7684\u5feb\u901f<\/span>\u6d88\u9664\u3002\u5229\u59a5\u6614\u5355\u6297\u662f\u4e00\u79cd\u6297CD20 \u5355\u514b\u9686\u6297\u4f53\uff0c\u88ab\u6279\u51c6\u7528\u4e8e<\/span>\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u5176\u836f\u4ee3\u52a8\u529b\u5b66\u8868\u73b0\u51fa<\/span>\u65f6\u95f4\u4f9d\u8d56\u6027\uff0c\u8fd9\u53ef\u80fd\u4e0e\u9776\u53d7\u4f53\u6570\u76ee\u968f\u7740\u65f6\u95f4\u53d8\u5316\u6709\u5173\u3002<\/span><\/p>\n

\u5229\u59a5<\/span>\u6614\u5355\u6297\u5728\u5faa\u73afB \u7ec6\u80de\u4e0a\u7684CD20 \u6570\u76ee\u8f83\u591a\u7684\u60a3\u8005\u4f53\u5185\u8868\u73b0\u51fa<\/span>\u9776\u53d7\u4f53\u4ecb\u5bfc\u7684\u6d88\u9664\u901f\u7387\u66f4\u5feb\u3002\u6b64\u5916\uff0c\u5173\u4e8e\u5229\u59a5\u6614\u5355\u6297\u591a\u5242<\/span>\u91cf\u7814\u7a76\u62a5\u9053\uff0c\u968f\u7740\u8f93\u6ce8\u6b21\u6570\u7684\u589e\u52a0\uff0c\u5176\u6d88\u9664\u7387\u968f\u4e4b\u964d\u4f4e\uff0c\u8fd9\u53ef<\/span>\u80fd\u662f\u7531\u4e8e\u5229\u59a5\u6614\u5355\u6297\u6cbb\u7597\u540e\u9776\u7ec6\u80de\u6570\u91cf\u51cf\u5c11\uff0c\u5bfc\u81f4\u9776\u53d7\u4f53\u4ecb<\/span>\u5bfc\u7684\u6d88\u9664\u4f5c\u7528\u4e0b\u964d\u6240\u81f4\u3002<\/span><\/p>\n

\u7531\u4e8e\u9776\u53d7\u4f53\u6570\u91cf\u6709\u9650\uff0c\u8be5\u6d88\u9664\u9014\u5f84\u901a\u5e38\u662f\u53ef\u9971\u548c\u7684\uff0c\u56e0\u6b64\uff0c \u8be5\u9014\u5f84\u4e5f\u662f\u5927\u5206\u5b50\u836f\u7269\u975e\u7ebf\u6027PK \u7279\u6027\u7684\u91cd\u8981\u539f\u56e0\u4e4b<\/span>\u4e00\uff0c\u4e14\u751f\u7269\u836f\u7269\u53d1\u6325\u836f\u6548\u4e5f\u4f1a\u4f7f\u5f97\u9776\u53d7\u4f53\u6570\u76ee\u6539\u53d8\uff0c\u8fdb\u4e00\u6b65<\/span>\u6539\u53d8\u9776\u53d7\u4f53\u4ecb\u5bfc\u7684\u836f\u7269\u6d88\u9664\u901f\u7387\u3002<\/span><\/p>\n

\u56e0\u6b64\uff0c\u5728\u8bbe\u8ba1\u4e0b\u4e00\u4ee3\u751f\u7269<\/span>\u5927\u5206\u5b50\u836f\u7269\u65f6\uff0c\u9700\u5728\u7814\u53d1\u7684\u65e9\u671f\u5bf9\u9776\u53d7\u4f53\u4ecb\u5bfc\u7684\u6d88\u9664\u4f5c\u7528\u8fdb<\/span>\u884c\u7814\u7a76\uff0c\u4ee5\u907f\u514d\u4e34\u5e8a\u4e0a\u56e0\u8be5\u6d88\u9664\u9014\u5f84\u5bfc\u81f4\u7684\u5206\u5b50\u5438\u6536\u548c\u751f\u7269<\/span>\u5229\u7528\u5ea6\u5dee\u3001\u800c\u9020\u6210\u4e0d\u5fc5\u8981\u7684\u5931\u8d25\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n
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1.3.2 Fc \u53d7\u4f53\u4ecb\u5bfc\u7684\u6d88\u9664<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

Fc\u03b3Rs \u901a\u5e38\u8868\u8fbe\u4e8e\u5355\u6838\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u7b49\u5404\u79cd\u514d\u75ab\u7ec6\u80de\u8868\u9762\uff0c\u53ef\u8bc6\u522b\u751f\u7269\u5206\u5b50<\/span>Fc \u533a\u57df\uff0c\u5e76\u4ecb\u5bfc\u5176\u5185\u5316\u53ca\u968f\u540e\u7684\u7ec6\u80de\u5185\u5206\u89e3\u4ee3\u8c22\u3002<\/span><\/p>\n

Fc \u53d7\u4f53\u4e0d<\/span>\u4ec5\u53ef\u4ecb\u5bfc\u5185\u6e90\u6027IgG \u7684\u6d88\u9664\uff0c\u4e5f\u53ef\u4ee5\u4ecb\u5bfc\u5916\u6e90\u6027\u6cbb\u7597\u6027\u86cb\u767d<\/span>\u7684\u6d88\u9664\uff0c \u56e0\u6b64\u8be5\u9014\u5f84\u4e3a\u975e\u7279\u5f02\u6027\u6d88\u9664\u9014\u5f84\u3002<\/span><\/p>\n

Fc \u53d7\u4f53\u53c2\u4e0eFc<\/span>\u878d\u5408\u86cb\u767d\u3001\u6297\u4f53\u7c7b\u836f\u7269\u548c\u53ef\u6eb6\u6027\u836f\u7269-\u9776\u590d\u5408\u7269\u7684\u80de\u541e\u6d88\u9664<\/span>\u8fc7\u7a0b\u3002\u76ee\u524d\uff0c\u5bf9Fc\u03b3Rs \u4ecb\u5bfc\u7684\u6d88\u9664\u7684\u610f\u4e49\u548c\u786e\u5207\u673a\u5236\u5c1a\u672a\u7814<\/span>\u7a76\u900f\u5f7b\u3002<\/span><\/p>\n

Kasturirangan S \u7b49\u8bbe\u8ba1\u7684\u9776\u5411\u53ef\u6eb6\u6027IL-6 \u4e0a\u4e0d\u540c<\/span>\u8868\u4f4d\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u4ee5\u963b\u65adIL-6 \u4ecb\u5bfc\u7684\u4fe1\u53f7\u3002<\/span><\/p>\n

\u8be5\u6297\u4f53\u7531\u4e8e<\/span>\u53ef\u4ee5\u7ed3\u5408\u6297\u539f\u4e0d\u540c\u8868\u4f4d\uff0c\u5f62\u6210\u66f4\u590d\u6742\u514d\u75ab\u590d\u5408\u7269\uff0c\u76f8\u8f83\u4e8e\u542b<\/span>\u6709\u5355\u4e2a\u6297\u539f\u6297\u4f53\u7684\u514d\u75ab\u590d\u5408\u7269\uff0c \u8fd9\u4e9b\u590d\u5408\u7269\u80fd\u66f4\u5feb\u901f\u7ed3\u5408<\/span>Fc\u03b3Rs \u5e76\u8bf1\u5bfc\u541e\u566c\u548c\u964d\u89e3\uff0c \u4fc3\u4f7f\u6297\u539f\u88ab\u8fc5\u901f\u4e2d\u548c\u6d88\u9664\u7684\u540c<\/span>\u65f6\uff0c\u4e0d\u53ef\u907f\u514d\u4e5f\u4f1a\u5f71\u54cd\u6297\u4f53\u7684PK\u3002\u4f46\u662f\uff0c\u6709\u7814\u7a76\u8868\u660e\uff0cFc\u03b3R<\/span>\u4ecb\u5bfc\u7684\u6d88\u9664\u5bf9\u4e8emAb \u53ef\u80fd\u4ec5\u8d77\u5f88\u5c0f\u7684\u4f5c\u7528\u3002<\/span><\/p>\n

\u7efc\u4e0a\uff0cFc\u03b3Rs<\/span>\u4ecb\u5bfc\u7684\u6d88\u9664\u4f5c\u7528\u5bf9\u4e8e\u9776\u5411\u53ef\u6eb6\u6027\u6297\u539f\u548c\u7ec6\u80de\u8868\u9762\u6297\u539f\u7684\u5f71<\/span>\u54cd\u6709\u6240\u533a\u522b\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n
\n

1.3.3 \u7cd6\u53d7\u4f53\u4ecb\u5bfc\u7684\u6d88\u9664<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u7cd6\u86cb\u767d\u53d7\u4f53\u4ecb\u5bfc\u7684\u751f\u7269\u5927\u5206\u5b50\u6d88\u9664\u4e3b\u8981\u6709\u4e24\u6761\u9014\u5f84\uff1a\u53bb\u553e\u6db2\u9178\u7cd6\u86cb\u767d\u53d7\u4f53\uff08Asialoglycoprotein <\/span>Receptor\uff0cASGPR\uff09 \u4ecb\u5bfc\u7684\u6d88\u9664\u548c\u7518\u9732\u7cd6\u53d7\u4f53\uff08Mannose <\/span>Receptor\uff0cMR\uff09 \u4ecb\u5bfc\u7684\u6d88\u9664\u3002<\/span><\/p>\n

ASGPR \u4e3b\u8981\u8868\u8fbe\u5728\u809d\u7aa6\u72b6\u95f4\u9699<\/span>\u7684\u809d\u5b9e\u8d28\u7ec6\u80de\u8868\u9762\uff0c \u53ef\u8bc6\u522b\u7cd6\u94fe\u672b\u7aef\u7684\u534a\u4e73\u7cd6\u6216N-\u4e59\u9170\u534a<\/span>\u4e73\u7cd6\u80fa\u6b8b\u57fa\u800c\u4ecb\u5bfc\u7cd6\u86cb\u767d\u88ab\u809d\u7ec6\u80de\u5185\u541e\u964d\u89e3\uff0c\u5728\u7cd6\u86cb\u767d\u4ee3\u8c22<\/span>\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002<\/span><\/p>\n

\u672c\u8bfe\u9898\u7ec4\u524d\u671f\u7814\u7a76\u8868\u660e\uff0c\u76f8\u8f83\u4e8e\u553e\u6db2\u9178\u542b<\/span>\u91cf\u9ad8\u7684\u5bf9\u7167\u7cd6\u86cb\u767d\u836f\u7269\uff0c\u4f4e\u553e\u6db2\u9178\u542b\u91cf\u7684\u51dd\u8840\u56e0\u5b50VII \u548c\u5e15<\/span>\u59a5\u73e0\u5355\u514b\u9686\u6297\u4f53\u5747\u7531\u4e8eASGPR \u4eb2\u548c\u529b\u66f4\u9ad8\uff0c \u800c\u88ab\u809d\u7ec6\u80de\u5185<\/span>\u541e\u6d88\u9664\u66f4\u660e\u663e\uff0c\u4f53\u5185\u534a\u8870\u671f\u4e5f\u76f8\u5e94\u8f83\u77ed\u3002<\/span><\/p>\n

\u7518\u9732\u7cd6\u53d7\u4f53\u4e3b\u8981<\/span>\u8868\u8fbe\u5728\u5de8\u566c\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u7ec6\u80de\u819c\u8868\u9762\uff0c\u53ef\u8bc6\u522b\u7cd6\u94fe\u672b<\/span>\u7aef\u7684\u7518\u9732\u7cd6\u548cN-\u4e59\u9170\u8461\u8404\u7cd6\u80fa\u6b8b\u57fa\u800c\u4ecb\u5bfc\u7cd6\u86cb\u767d\u6d88\u9664\u3002\u672b<\/span>\u7aef\u4e3aMan5 \u805a\u7cd6\u7684IgG \u6d88\u9664\u7387\u660e\u663e\u5feb\u4e8e\u5177\u6709\u66f4\u590d\u6742\u7cd6\u57fa\u5316\u7684<\/span>\u86cb\u767d\u836f\u7269\u3002<\/span><\/p>\n

Liu L \u7b49\u7684\u7814\u7a76\u8868\u660e\uff0c\u6bd5\u8d64\u9175\u6bcd\u8868\u8fbe\u7684\u878d\u5408\u86cb<\/span>\u767d\u503e\u5411\u4ea7\u751f\u9ad8\u7518\u9732\u7cd6\u578b\uff0c \u4e14\u8be5\u7cd6\u578b\u7684Fc \u878d\u5408\u86cb\u767d\u4f1a\u88ab\u9ad8\u8868<\/span>\u8fbe\u7518\u9732\u7cd6\u53d7\u4f53\u7684\u809d\u810f\u7aa6\u5185\u76ae\u7ec6\u80de\u7ed3\u5408\u800c\u5feb\u901f\u6d88\u9664\u3002<\/span><\/p>\n

\u5c3d\u7ba1\u76ee\u524d<\/span>\u5df2\u7814\u7a76\u4e86\u5f88\u591a\u7cd6\u57fa\u5316\u5bf9\u4e8e\u7cd6\u86cb\u767d\u4ee3\u8c22\u7684\u5f71\u54cd\uff0c\u4f46\u5e76\u6ca1\u6709\u5f62\u6210<\/span>\u5b8c\u5168\u4e00\u81f4\u7684\u7ed3\u8bba\u3002\u7814\u7a76\u8005\u53ef\u4ee5\u53c2\u8003\u73b0\u6709\u7684\u7814\u7a76\u6210\u679c\uff0c\u5728\u65b0\u836f<\/span>\u7814\u53d1\u4e2d\uff0c\u5bf9\u7cd6\u57fa\u5316\u52a0\u4ee5\u91cd\u89c6\uff0c\u5e76\u5efa\u7acb\u76f8\u5e94\u7684\u7814\u7a76\u65b9\u6cd5\u8bc4\u4f30\u7cd6\u53d7<\/span>\u4f53\u5bf9\u76ee\u7684\u5206\u5b50\u4ee3\u8c22\u5f71\u54cd\uff0c\u4e8e\u7814\u53d1\u65e9\u671f\u89c4\u907f\u4ee3\u8c22\u6027\u8d28\u5dee\u7684\u5206\u5b50\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n
<\/section>\n
\n

1.3.4 \u65b0\u751f\u513fFc \u53d7\u4f53\uff08FcRn\uff09\u4ecb\u5bfc\u7684\u8f6c\u80de\u541e\u4f5c\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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FcRn \u53d7\u4f53\u4e3b\u8981\u8868\u8fbe\u5728\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u4e0a\uff0c\u5728\u7279\u5b9a\u86cb\u767d\u836f\u7269\u6d88\u9664\u4e2d\u53d1\u6325<\/span>\u4fdd\u62a4\u4f5c\u7528\u3002\u7ec6\u80de\u901a\u8fc7\u80de\u996e\u4f5c\u7528\u6444\u53d6\u6cbb\u7597\u6027\u86cb\u767d\u8d28\uff08\u5982IgG\u3001Fc<\/span>\u878d\u5408\u86cb\u767d\u548c\u4eba\u8840\u6e05\u767d\u86cb\u767d\u878d\u5408\u86cb\u767d\uff09\uff0c\u5f62\u6210\u5305\u542bFcRn \u7684\u5185\u4f53<\/span>\u5c0f\u6ce1\u3002<\/span><\/p>\n

FcRn \u4e0e\u86cb\u767d\u7ed3\u5408\u5448pH \u4f9d\u8d56\u6027\uff0c\u5185\u5316\u7684\u86cb\u767d\u5728\u9178\u6027<\/span>\u5185\u4f53\u4e2d\u4e0eFcRn \u7ed3\u5408\u5e76\u5faa\u73af\u81f3\u7ec6\u80de\u8868\u9762\uff0c\u901a\u8fc7\u80de\u5410\u4f5c\u7528\u91cd\u65b0<\/span>\u91ca\u653e\u81f3\u7ec6\u80de\u5916\uff0c\u5728\u751f\u7406pH \u4e0b\u86cb\u767d\u4e0eFcRn \u89e3\u79bb\uff0c\u7ee7\u7eed\u53d1\u6325\u4f5c<\/span>\u7528\u3002<\/span><\/p>\n

IgG \u4e0eFcRn \u4e4b\u95f4\u7ed3\u5408\u4eb2\u548c\u529b\u4f1a\u5f71\u54cdIgG \u7684\u534a\u8870\u671f\uff0c\u4f8b\u5982IgG1\uff0cIgG2 \u548cIgG4 \u7684\u6d88\u9664\u534a\u8870\u671f\u4e3a18~21 \u5929\uff0c \u663e\u8457\u957f\u4e8e<\/span>\u76f8\u4f3c\u5206\u5b50\u91cf\u7684\u5176\u4ed6\u86cb\u767d\u8d28\u3002<\/span><\/p>\n

\u7814\u7a76\u8005\u5e94\u7528\u8be5\u4ee3\u8c22\u9003\u9038\u673a\u5236\u5bf9\u51e0<\/span>\u79cd\u6297\u4f53\u7684FcRn \u7ed3\u5408\u4f4d\u70b9\u8fdb\u884c\u7279\u5f02\u6027\u7a81\u53d8\u4ee5\u589e\u52a0\u5176\u4ee3\u8c22\u7a33<\/span>\u5b9a\u6027\uff0c\u5ef6\u957f\u5faa\u73af\u534a\u8870\u671f\u3002<\/span>\u5bf9\u86cb\u767d\u878d\u5408Fc \u6216\u767d\u86cb\u767d\u7ed3\u6784\u57df\u662f<\/span>\u5ef6\u957f\u76ee\u6807\u5206\u5b50\u534a\u8870\u671f\u7684\u6709\u6548\u4f18\u5316\u7b56\u7565\u4e4b\u4e00\u3002<\/span><\/p>\n

\u5206\u5b50\u91cf\u4e3a19<\/span>kDa \u7684FGF21 \u5177\u6709\u589e\u52a0\u8102\u80aa\u7ec6\u80de\u5bf9\u8461\u8404\u7cd6\u6444\u53d6\uff0c \u6539\u5584\u80f0\u5c9b<\/span>\u7d20\u654f\u611f\u6027\u548c\u8461\u8404\u7cd6\u8010\u91cf\u7b49\u6d3b\u6027\uff0c\u800c\u6210\u4e3a\u6cbb\u7597\u4ee3\u8c22\u6027\u75be\u75c5\u7684\u4f18<\/span>\u826f\u9776\u70b9\uff0c \u4f46\u662f\u4f53\u5185\u534a\u8870\u671f\u7ea60.5~2 h\uff0c \u5927\u5927\u9650\u5236\u4e86\u5176\u4e34\u5e8a\u5e94<\/span>\u7528\u3002<\/span><\/p>\n

Yan \u7b49\u901a\u8fc7\u539f\u578bFGF21 \u8fdb\u884c\u7cd6\u57fa\u5316\u6539\u9020\u548cFc \u878d\u5408\u800c<\/span>\u6539\u5584\u5176\u9176\u7a33\u5b9a\u6027\u548cFcRn \u4f9d\u8d56\u7684\u4ee3\u8c22\u9003\u9038\uff0c\u83b7\u5f97\u957f\u6548FGF21<\/span>\u7c7b\u4f3c\u7269Fc-FGF21[R19V][N171]\uff0c\u8be5\u7c7b\u4f3c\u7269\u5728\u98df\u87f9\u7334\u4f53\u5185\u534a\u8870<\/span>\u671f\u957f\u8fbe\u7ea6200 h\uff0c\u5927\u5927\u589e\u52a0\u4e86FGF21 \u7528\u4e8e\u4e34\u5e8a\u4ee3\u8c22\u6027\u75be\u75c5\u7684<\/span>\u6162\u6027\u6cbb\u7597\u7684\u6f5c\u529b\u3002<\/span><\/p>\n

Jenny \u7b49\u7814\u7a76\u4e86FcRn \u4ecb\u5bfc\u91cd\u7ec4\u51dd\u8840\u56e0\u5b50<\/span>IX \u767d\u86cb\u767d\u878d\u5408\u86cb\u767d\uff08rIX-FP\uff09\u518d\u5faa\u73af\uff0c\u7ed3\u679c\u663e\u793a\uff0crIX-FP \u53ef\u4ee5<\/span>\u5728\u9178\u6027\u6761\u4ef6\u4e0b\u88abFcRn \u4ecb\u5bfc\u5185\u5316\uff0c \u901a\u8fc7\u65e9\u671f\u5185\u4f53-\u5faa\u73af\u5185\u4f53<\/span>\u9014\u5f84\u907f\u514d\u5176\u88ab\u6eb6\u9176\u4f53\u964d\u89e3\uff0c\u5927\u5927\u5ef6\u957f\u5176\u534a\u8870\u671f\uff084~5 \u500d\uff09\uff0c\u5e76<\/span>\u4e14\u8be5\u56e2\u961f\u8fd8\u5efa\u7acb\u4e86\u57fa\u4e8e\u7ec6\u80de\u8bc4\u4f30\u6cbb\u7597\u6027\u86cb\u767d\u5faa\u73af\u80fd\u529b\u7684\u65b9<\/span>\u6cd5\u3002<\/span><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0cFcRn \u5bf9mAb \u7b49\u751f\u7269\u836f\u7269PK \u6027\u8d28\u5f71\u54cd\u5de8\u5927\uff0c<\/span>\u5728\u836f\u7269\u5206\u5b50\u8bbe\u8ba1\u65f6\u53ef\u5408\u7406\u5e94\u7528FcRn \u4ecb\u5bfc\u7684\u6d88\u9664\u9003\u9038\uff0c\u6539\u5584<\/span>\u5206\u5b50PK \u6027\u8d28\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/span> <\/span> <\/section>\n
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1.4 \u6297\u836f\u7269\u6297\u4f53\u4ecb\u5bfc\u7684\u6d88\u9664<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5411\u60a3\u8005\u65bd\u7528\u6cbb\u7597\u6027\u86cb\u767d\u53ef\u5f15\u53d1\u514d\u75ab\u5e94\u7b54\uff0c\u5bfc\u81f4\u6297\u836f\u7269\u6297\u4f53\uff08Anti Drug Antibody\uff0cADA\uff09\u5f62\u6210\uff0c\u8fdb\u800c\u6539\u53d8\u86cb\u767d\u8d28\u6cbb\u7597\u5242<\/span>\u7684\u6d88\u9664\u7387\u3002\u6240\u6709\u86cb\u767d\u8d28\u6cbb\u7597\u5242\u90fd\u5177\u6709\u6f5c\u5728\u7684\u514d\u75ab\u539f\u6027\uff0c\u5176\u514d<\/span>\u75ab\u539f\u6027\u6f5c\u529b\u4e0e\u86cb\u767d\u8d28\u5206\u5b50\u4e2d\u975e\u4eba\u6e90\u5e8f\u5217\u7684\u90e8\u5206\u3001\u7ed9\u836f\u9014\u5f84\u4ee5<\/span>\u53ca\u6cbb\u7597\u7684\u5242\u91cf\u548c\u6301\u7eed\u65f6\u95f4\u7b49\u56e0\u7d20\u6709\u5173\u3002<\/span><\/p>\n

\u4e00\u822c\u800c\u8a00\uff0c\u5bf9\u514d\u75ab\u5e94<\/span>\u7b54\u7684\u5f71\u54cd\u4e0e\u6297\u4f53\u7684\u4eba\u6e90\u5316\u7a0b\u5ea6\u6210\u53cd\u6bd4\uff0c\u4f46\u5168\u4eba\u6e90\u6297\u4f53\u53ca\u5176\u884d<\/span>\u751f\u7269\u4f9d\u7136\u53ef\u80fd\u5b58\u5728\u8f83\u9ad8\u7684\u514d\u75ab\u539f\u6027\u3002\u76f8\u8f83\u4e8e\u808c\u6ce8\u548c\u9759\u8109\u6ce8<\/span>\u5c04\uff0c\u86cb\u767d\u836f\u7269\u76ae\u4e0b\u6ce8\u5c04\u66f4\u5bb9\u6613\u5f15\u8d77\u514d\u75ab\u539f\u6027\u3002<\/span><\/p>\n

mAb \u7684\u5242\u91cf\u53ef<\/span>\u80fd\u4e0e\u514d\u75ab\u539f\u6027\u6210\u53cd\u6bd4\u5173\u7cfb\uff0c\u6709\u7814\u7a76\u8868\u660e\uff0c\u4f4e\u5242\u91cf\u7684mAb \u7ecf<\/span>\u5e38\u5f15\u8d77\u66f4\u5927\u7684\u514d\u75ab\u5e94\u7b54\uff0c\u5e76\u4e14\u4ea7\u751f\u514d\u75ab\u539f\u6027\u7684\u6982\u7387\u4e00\u822c\u968f\u6cbb<\/span>\u7597\u65f6\u95f4\u7684\u5ef6\u957f\u800c\u589e\u52a0\u3002<\/span><\/p>\n

ADA \u4ecb\u5bfc\u836f\u7269\u6d88\u9664\u9014\u5f84\u7684\u5f3a\u5f31\u53d6\u51b3\u4e8e\u5927\u5206\u5b50\u836f\u7269\u4e0a\u53ef\u88abADA \u8bc6\u522b\u7684\u4f4d\u70b9\u6570\u76ee\u3002ADA \u548c\u836f\u7269\u7ed3\u5408\u540e\u5f62\u6210\u4e2d\u548c\u6297\u4f53<\/span>\u548c\u514d\u75ab\u590d\u5408\u7269\uff0c\u8fdb\u800c\u89e6\u53d1\u7f51\u72b6\u5185\u76ae\u7cfb\u7edf\uff08RES\uff09\u4e2d\u7684\u86cb\u767d\u6c34\u89e3<\/span>\u6d88\u9664\uff0c\u9020\u6210\u836f\u7269\u7684\u6d88\u9664\u7387\u589e\u52a0\u3002<\/span><\/p>\n

\u82f1\u592b\u5229\u6614\u5355\u6297\u7279\u5f02\u6027\u9776\u5411\u4eba<\/span>\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u03b1\uff08TNF-\u03b1\uff09\uff0c\u5728\u5bf9\u5176\u7814\u7a76\u4e2d\u53d1\u73b0\uff0c\u5f53\u60a3\u8005\u4f53\u5185<\/span>\u5f62\u6210ADA \u540e\uff0c\u4f1a\u52a0\u901f\u82f1\u592b\u5229\u6614\u5355\u6297\u7684\u6d88\u9664\u3002<\/span><\/p>\n

\u76f8\u53cd\uff0c\u82e5ADA \u4e0e\u836f\u7269\u5f62\u6210\u7684\u514d\u75ab\u590d\u5408\u7269\u4e0d\u89e6\u53d1RES \u6d88\u9664\u7cfb\u7edf\uff0c\u5219\u53ef\u4ee5\u4f5c\u4e3a\u8f7d\u4f53\u86cb\u767d\uff0c\u5ef6\u957f\u86cb\u767d\u8d28\u6cbb\u7597\u5242\u5982\u7ec6\u80de\u56e0<\/span>\u5b50\u548c\u5404\u79cd\u6fc0\u7d20\u7c7b\u836f\u7269\u7684\u5faa\u73af\u534a\u8870\u671f\u3002\u7136\u800c\uff0c\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u514d<\/span>\u75ab\u539f\u6027\u6297\u4f53\u5bfc\u81f4\u6cbb\u7597\u6027\u86cb\u767d\u8d28\u7684\u589e\u5f3a\u6d88\u9664\u3002<\/span><\/p>\n

\u56e0\u6b64\uff0c\u4e3a\u4e86\u5c3d\u53ef<\/span>\u80fd\u907f\u514d\u514d\u75ab\u539f\u6027\u5f15\u8d77\u7684\u836f\u7269\u589e\u5f3a\u6d88\u9664\u7684\u98ce\u9669\uff0c\u7814\u5236\u4e0b\u4e00\u4ee3\u86cb<\/span>\u767d\u6cbb\u7597\u5242\u65f6\uff0c\u5e94\u91c7\u7528\u5404\u79cd\u8ba1\u7b97\u673a\uff0c\u4f53\u5916\u548c\u4e34\u5e8a\u524d\u5de5\u5177\u5728\u65e9\u671f<\/span>\u7814\u53d1\u9636\u6bb5\u5bf9\u5019\u9009\u836f\u7269\u8fdb\u884c\u514d\u75ab\u539f\u6027\u9884\u6d4b\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2<\/strong><\/p>\n<\/section>\n

\n
<\/section>\n
<\/section>\n<\/section>\n
<\/section>\n<\/section>\n<\/section>\n
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\u751f\u7269\u5927\u5206\u5b50\u836f\u7269\u4ee3\u8c22\u4f53\u5916\u9884\u6d4b\u6a21\u578b\u7814\u7a76\u8fdb\u5c55<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ee\u524d\u5e38\u7528\u7684\u751f\u7269\u5927\u5206\u5b50\u836f\u7269\u4ee3\u8c22\u9884\u6d4b\u6a21\u578b\u6709\u9776\u4ecb\u5bfc\u7684\u836f\u7269\u5904\u7f6e\uff08Target Mediated Drug Disposition\uff0cTMDD\uff09\u6a21\u578b\u548c<\/span>\u751f\u7406\u836f\u4ee3\u52a8\u529b\u5b66\uff08Physiologically Based Pharmacokinetic\uff0c<\/span>PBPK\uff09\u6a21\u578b\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.1 TMDD \u6a21\u578b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TMDD \u63cf\u8ff0\u836f\u7269\u4e0e\u5176\u836f\u7406\u9776\u70b9\uff08\u5982\u53d7\u4f53\u3001\u9176\u6216\u8f6c\u8fd0\u86cb\u767d\uff09\u7684\u9ad8\u4eb2\u548c\u529b\u7ed3\u5408\u800c\u5f71\u54cd\u5176PK \u7279\u5f81\u7684\u7684\u73b0\u8c61\u3002TMDD \u6700\u663e\u8457<\/span>\u7684\u7279\u5f81\u4e3a\u751f\u7269\u5236\u5242\u7684\u53ef\u9971\u548c\u6d88\u9664\u673a\u5236\uff0c\u7279\u522b\u662f\u80bd\u3001\u86cb\u767d\u8d28\u548c<\/span>\u5355\u514b\u9686\u6297\u4f53\u3002\u5f53\u836f\u7269\u6d53\u5ea6\u4f4e\u4e8e\u67d0\u4e00\u9608\u503c\u65f6\uff0c\u6781\u6709\u53ef\u80fd\u8868\u73b0\u51fa<\/span>\u975e\u7ebf\u6027PK \u7279\u5f81\uff0c \u8fd9\u4e0e\u9776\u5bb9\u91cf\u5bf9\u836f\u7269\u7684\u6d88\u9664\u5f71\u54cd\u5bc6\u5207\u76f8\u5173\u3002<\/span><\/p>\n

TMDD \u6a21\u578b\u6700\u65e9\u7531Yan X \u7b49\u4e8e2001 \u5e74\u5efa\u7acb\uff0c \u800c\u5177\u6709TMDD \u7279\u5f81\u7684\u836f\u7269\u4e3b\u8981\u662f\u751f\u7269\u5236\u5242\uff0c\u5305\u62ec\u5355\u514b\u9686\u6297\u4f53\u3001\u7ec6\u80de<\/span>\u56e0\u5b50\u548c\u751f\u957f\u56e0\u5b50\u3002<\/span><\/p>\n

TMDD \u6a21\u578b\u5982\u56fe1 \u6240\u793a\uff0c\u7b80\u800c\u8a00\u4e4b\uff0c\u4e2d\u592e<\/span>\u9694\u5ba4\u4e2d\u7684\u6e38\u79bb\u836f\u7269\uff08C\uff09\u4ee5\u4e8c\u7ea7\u901f\u7387\u5e38\u6570\uff08Kon\uff09\u4e0e\u5176\u9776\u53d7\u4f53\uff08R\uff09\u7ed3\u5408\uff0c\u5f62\u6210\u836f\u7269-\u9776\u53d7\u4f53\u590d\u5408\u7269\uff08RC\uff09\u3002<\/span><\/p>\n

\"\u751f\u7269\u5927\u5206\u5b50\u836f\u7269\u4ee3\u8c22\u6d88\u9664\u9014\u5f84\u53ca\u4f53\u5916\u4ee3\u8c22\u7814\u7a76\u65b9\u6cd5\u8fdb\u5c55\"<\/p>\n

RC \u53ef\u4ee5\u4ee5\u4e00\u7ea7\u901f\u7387<\/span>\uff08Koff<\/span><\/sub>\uff09\u89e3\u79bb\u6216\u4ee5\u4e00\u7ea7\u901f\u7387\uff08K<\/span>int<\/span><\/sub><\/span>\uff09\u5185\u5316\u5e76\u964d\u89e3\u3002\u6e38\u79bb\u836f\u7269\u4e5f\u53ef\u4ee5<\/span>\u901a\u8fc7\u4e00\u7ea7\u6d88\u9664\u8fc7\u7a0b\uff08K<\/span>el<\/span><\/sub><\/span>\uff09\u4ece\u4e2d\u592e\u5ba4\u6d88\u9664\u3002\u672a\u7ed3\u5408\u7684\u9776\u53d7\u4f53\u5219\u53ef<\/span>\u4ee5\u4ee5\u96f6\u7ea7\u901f\u7387\uff08K<\/span>syn<\/span><\/sub><\/span>\uff09\u5408\u6210\u5e76\u4ee5\u4e00\u7ea7\u901f\u7387\uff08K<\/span>deg<\/span><\/sub><\/span>\uff09\u964d\u89e3\u3002<\/span><\/p>\n

\u7531\u4e8e\u5b8c\u6574TMDD \u6a21\u578b\u53c2\u6570\u8f83\u591a\uff0c\u4f7f\u7528\u590d\u6742\uff0c\u56e0\u800c\u9664\u4e86\u5b8c<\/span>\u6574TMDD \u6a21\u578b\u5916\uff0c \u7814\u7a76\u8005\u4eec\u8fd8\u5efa\u7acb\u4e86\u5404\u79cd\u5b9e\u7528\u6027\u66f4\u5f3a\u7684\u7b80<\/span>\u5316\u7684TMDD \u6a21\u578b\u3002<\/span><\/p>\n

\u4f8b\u5982\u51c6\u5e73\u8861\u6a21\u578b\uff08QE\uff09\u3001\u51c6\u7a33\u6001\u6a21\u578b\uff08QSS\uff09\u3001<\/span>\u5feb\u901f\u7ed3\u5408\u6a21\u578b\uff08RB\uff09\u3001Wagner \u6a21\u578b\u548c\u7c73\u6c0f\u6a21\u578b\uff08MM\uff09\u3002<\/span><\/p>\n

QE \u6a21<\/span>\u578b\u5047\u5b9a\u836f\u7269-\u9776\u53d7\u4f53\u590d\u5408\u7269\u7684\u7ed3\u5408\u548c\u89e3\u79bb\u4e4b\u95f4\u5df2\u8fbe\u5230\u5e73\u8861\uff0c<\/span>\u8be5\u7b80\u5316\u6a21\u578b\u53ef\u7528\u4e8e\u9884\u6d4b\u836f\u7269\u7684\u7ec8\u672b\u534a\u8870\u671f\u4ee5\u53ca\u9ad8\u5242\u91cf\u65f6\u836f<\/span>\u7269\u7684\u6d88\u9664\u901f\u7387\u3002<\/span><\/p>\n

QSS \u6a21\u578b\u5047\u8bbe\u836f\u7269\u9776\u53d7\u4f53\u7ed3\u5408\u8db3\u591f\u5feb\u4ee5\u81f3<\/span>\u4e8e\u5ffd\u7565\u836f\u7269\u89e3\u79bb\/\u5206\u5e03\/\u6d88\u9664\u548c\u836f\u7269-\u9776\u53d7\u4f53\/\u9776\u53d7\u4f53\u6d88\u9664\u8fc7<\/span>\u7a0b\u3002<\/span><\/p>\n

\u5f53\u836f\u7269-\u9776\u53d7\u4f53\u590d\u5408\u7269\u7684\u5185\u5316\u901f\u7387\u5e38\u6570\uff08K<\/span>int<\/span><\/sub><\/span>\uff09\u8fdc\u5927\u4e8e\u836f\u7269<\/span>\u4e0e\u9776\u53d7\u4f53\u7684\u89e3\u79bb\u901f\u7387\u5e38\u6570\uff08K<\/span>off<\/span><\/sub><\/span>\uff09\u65f6\uff0c\u8be5\u6a21\u578b\u6bd4QE \u6a21\u578b\u7684\u9884\u6d4b<\/span>\u7ed3\u679c\u66f4\u51c6\u786e\u3002<\/span><\/p>\n

QSS \u6a21\u578b\u53ef\u51c6\u786e\u9884\u6d4b\u53d7\u4f53\u6570\u91cf\u63a5\u8fd1\u96f6\u65f6\u7684\u9636<\/span>\u6bb5\uff0c\u800c\u5bf9\u4e8e\u836f\u7269\u800c\u8a00\u5927\u90e8\u5206\u5b9e\u9a8c\u5904\u4e8e\u8be5\u9636\u6bb5\uff0c\u56e0\u4e3a\u4ece\u7406\u8bba\u4e0a\u8bb2\uff0c<\/span>\u836f\u7269\u7684\u76ee\u7684\u662f\u4e0e\u53d7\u4f53\u7ed3\u5408\uff0c \u5e76\u5c3d\u53ef\u80fd\u957f\u65f6\u95f4\u4fdd\u6301\u5176\u7ed3\u5408\u3002<\/span>\u56e0\u6b64QSS \u6a21\u578b\u53ef\u9002\u7528\u4e8e\u591a\u6570\u6570\u636e\u70b9\u5e76\u9884\u6d4b\u51fa\u8f83\u51c6\u786e\u7684\u7ed3<\/span>\u679c\u3002<\/span><\/p>\n

RB \u6a21\u578b\u5047\u5b9aKint<\/span>\u53c2\u6570\u53ef\u4ee5\u5ffd\u7565\u4e0d\u8ba1\uff0c \u800cWagner \u6a21\u578b\u5047<\/span>\u5b9a\u9776\u53d7\u4f53\u603b\u6d53\u5ea6\u662f\u4e00\u4e2a\u5e38\u6570\u3002MM \u6a21\u578b\u6e90\u81ea\u9176\u52a8\u529b\u5b66\u4e2d\u7684\u7c73<\/span>\u6c0f\u65b9\u7a0b\uff0c\u8be5\u6a21\u578b\u5c06\u53cd\u5e94\u901f\u7387\u548c\u6d53\u5ea6\u5173\u8054\u8d77\u6765\uff0c\u5176\u6210\u7acb\u7684\u524d\u63d0<\/span>\u662fQE \u6216QSS \u5047\u8bbe\u6210\u7acb\uff0c\u6240\u4ee5MM \u6a21\u578b\u4e8b\u5b9e\u4e0a\u662fQE \u548cQSS<\/span>\u6a21\u578b\u7684\u7279\u4f8b\u3002<\/span><\/p>\n

\u82e5\u6e38\u79bb\u836f\u7269\u6d53\u5ea6\u8d85\u8fc7\u9776\u53d7\u4f53\u603b\u6d53\u5ea6\u6216\u836f\u7269-\u9776<\/span>\u53d7\u4f53\u590d\u5408\u7269\u5728\u836f\u7269\u7ed3\u5408\u9971\u548c\u65f6\u662f\u6052\u5b9a\u7684\uff0c\u5219MM \u6a21\u578b\u4e0eQSS<\/span>\u6a21\u578b\u76f8\u4f3c\uff0c\u4f46\u662f\u5f53\u6e38\u79bb\u836f\u7269\u548c\u603b\u836f\u7269\u6d53\u5ea6\u5dee\u5f02\u5f88\u5927\u65f6\uff0c\u8be5\u6a21<\/span>\u578b\u5219\u4e0d\u9002\u7528\u3002<\/span><\/p>\n

MM \u6a21\u578b\u5047\u5b9a\u9776\u53d7\u4f53\u88ab\u5b8c\u5168\u9971\u548c\uff0c\u56e0\u6b64\uff0c\u5f53\u836f\u7269<\/span>\u7684\u521d\u59cb\u6d53\u5ea6\u8f83\u5927\u65f6\uff08\u5373\u9ad8\u5242\u91cf\u7ed9\u836f\u65f6\uff09\uff0c\u8be5\u6a21\u578b\u9002\u7528\u6027\u8f83\u597d\u3002<\/span>MM \u6a21\u578b\u4e5f\u9002\u7528\u4e8e\u9884\u6d4b\u53d7\u4f53\u6570\u91cf\u63a5\u8fd1\u96f6\u65f6\u7684\u9636\u6bb5\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.2 PBPK\u6a21\u578b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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PBPK \u6a21\u578b\u662f\u7ed3\u5408\u751f\u7406\u5b66\u3001\u751f\u5316\u5b66\u548c\u89e3\u5256\u5b66\u7b49\u6a21\u62df\u673a\u4f53\u5faa\u73af\u7cfb\u7edf\u7684\u8840\u6db2\u6d41\u5411\uff0c\u5c06\u591a\u4e2a\u7ec4\u7ec7\u6216\u5668\u5b98\u7528\u8840\u6d41\u6d41\u5411\u7f51\u7edc\u52a0<\/span>\u4ee5\u8fde\u63a5\uff0c \u5e76\u9075\u5faa\u8d28\u91cf\u5e73\u8861\u539f\u7406\u6a21\u62df\u836f\u7269\u5728\u4f53\u5185\u7684\u4ee3\u8c22\u8fc7\u7a0b\uff0c<\/span>\u5176\u4e2d\u6bcf\u4e00\u4e2a\u623f\u5ba4\u4ee3\u8868\u4e00\u4e2a\u7ec4\u7ec7\u6216\u8005\u5668\u5b98\uff08\u89c1\u56fe2\uff09\u3002<\/span><\/p>\n

\"\u751f\u7269\u5927\u5206\u5b50\u836f\u7269\u4ee3\u8c22\u6d88\u9664\u9014\u5f84\u53ca\u4f53\u5916\u4ee3\u8c22\u7814\u7a76\u65b9\u6cd5\u8fdb\u5c55\"<\/p>\n

\u8be5\u6a21\u578b\u7531<\/span>Li L \u7b49\u4e8e1986 \u5e74\u9996\u6b21\u5efa\u7acb\uff0c\u662f\u7814\u7a76\u751f\u7406\u6761\u4ef6\u548c\u836f\u7269\u7279\u5f02<\/span>\u6027\u53c2\u6570\u5bf9PK \u5f71\u54cd\u7684\u6709\u529b\u5de5\u5177\u3002\u8fd1\u5e74\u6765\uff0cPBPK \u6a21\u578b\u5df2\u88ab\u6210\u529f<\/span>\u7528\u4e8e\u63cf\u8ff0\u4eba\u4f53\u6216\u52a8\u7269\u8840\u6d46\u548c\u5404\u79cd\u5668\u5b98\u4e2d\u6297\u4f53\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u3002<\/span><\/p>\n

Shah DK \u7b49\u5efa\u7acb\u4e86\u4e00\u4e2a\u5305\u542b16 \u4e2a\u7ec4\u7ec7\u533a\u5ba4\u7684\u5b8c\u6574PBPK<\/span>\u6a21\u578b\uff0c \u7528\u4e8e\u8868\u5f81\u5355\u514b\u9686\u6297\u4f53\u5728\u5404\u79cd\u4e34\u5e8a\u524d\u7269\u79cd\u548c\u4eba\u4f53\u5185\u7684<\/span>PK \u6027\u8d28\u3002<\/span><\/p>\n

\u7136\u800c\uff0c \u5b8c\u6574PBPK \u6a21\u578b\u975e\u5e38\u590d\u6742\uff0c \u4e14\u7ec4\u7ec7\u6297\u4f53\u6d53\u5ea6\u548cFcRn \u6d53\u5ea6\u7b49\u6570\u636e\u6709\u9650\uff0c \u88ab\u7528\u4e8e\u63cf\u8ff0\u4eba\u4f53\u4e2d\u836f\u7269\u5904\u7f6e\u65f6\u53ef\u80fd<\/span>\u4f1a\u51fa\u73b0\u9519\u8bef\u3002\u8fdb\u800c\u884d\u751f\u51fa\u4e86\u8ff7\u4f60PBPK\uff08mPBPK\uff09\u6a21\u578b\uff0c\u8be5\u6a21<\/span>\u578b\u8003\u8651\u4e86\u5728\u836f\u7269\u5904\u7f6e\u4e2d\u7684\u5173\u952e\u8981\u7d20\uff0c\u800c\u4e0d\u9700\u8981\u5927\u91cf\u7684\u4e0d\u80fd\u53ef<\/span>\u9760\u5730\u88ab\u6d4b\u91cf\u3001\u83b7\u5f97\u6216\u4f30\u8ba1\u7684\u81c6\u6d4b\u53c2\u6570\u3002<\/span><\/p>\n

mPBPK \u6a21\u578b\u6700\u521d\u7531<\/span>Cao Y \u7b49\u5efa\u7acb\uff0c\u5e76\u5c06\u5176\u5e94\u7528\u4e8e\u89e3\u91ca\u4eba\u7c7b\u53d7\u8bd5\u8005\u4e2d\u6cbb\u7597\u6027\u5355<\/span>\u514b\u9686\u6297\u4f53\u7684PK\u3002\u4f46\u8be5\u6a21\u578b\u5e76\u6ca1\u6709\u6db5\u76d6\u5185\u76ae\u7ec6\u80de\u4e2d\u7684FcRn<\/span>\u518d\u5faa\u73af\u673a\u5236\u3002<\/span><\/p>\n

\u968f\u540e\uff0cLi L \u7b49\u5efa\u7acb\u4e86\u5305\u62ecFcRn \u5faa\u73af\u673a\u5236\u7684<\/span>mPBPK \u6a21\u578b\uff0c\u4ee5\u63cf\u8ff0\u4eba\u7c7b\u53d7\u8bd5\u8005\u4e2dIgG \u7684\u4ee3\u8c22\u3002\u7136\u800c\uff0c\u8be5\u6a21<\/span>\u578b\u4ecd\u7136\u5b58\u5728\u5c40\u9650\u6027\uff0c\u4f8b\u5982\uff0c\u7f3a\u4e4f\u975e\u5e73\u8861\u7684FcRn-\u6297\u4f53\u7ed3\u5408\u548c<\/span>\u4ece\u8840\u7ba1\u5230\u95f4\u8d28\u65c1\u7ec6\u80deIgG \u8f93\u9001\u53c2\u6570\u7b49\u3002<\/span><\/p>\n

\u7531\u4e8eIgG \u7559\u5728\u5185\u6db5\u4f53<\/span>\u4e2d\u7684\u65f6\u95f4\u4e0d\u8db3\u4ee5\u8fbe\u5230IgG \u548cFcRn \u4e4b\u95f4\u7684\u5e73\u8861\uff0c\u56e0\u6b64\uff0c\u63cf\u8ff0<\/span>FcRn \u548c\u6297\u4f53\u5728\u5185\u4f53\u4e2d\u7684\u76f8\u4e92\u4f5c\u7528\u65f6\uff0c \u975e\u5e73\u8861\u7ed3\u5408\u6bd4\u5e73\u8861\u7ed3<\/span>\u5408\u66f4\u5408\u7406\u3002<\/span><\/p>\n

Hardiansyah D \u7b49\u5efa\u7acb\u4e86\u4e00\u79cd\u53cc\u5b54\u8ff7\u4f60\u751f\u7406\u836f<\/span>\u4ee3\u52a8\u529b\u5b66\uff08mPBPK\uff09\u6a21\u578b\uff0c\u7528\u4e8e\u63cf\u8ff0\u4eba\u4f53\u4e2d\u6cbb\u7597\u6027IgG \u5355\u514b\u9686<\/span>\u6297\u4f53\u7684\u5904\u7f6e\u3002\u8be5\u6a21\u578b\u514b\u670d\u4e86\u5148\u524dPBPK \u6a21\u578b\u7684\u591a\u79cd\u5c40\u9650\uff0c\u5e76<\/span>\u80fd\u591f\u63cf\u8ff0\u5177\u6709\u4e0d\u540cFcRn \u7ed3\u5408\u7684\u4eb2\u5929\u7136IgG \u548c\u6cbb\u7597\u6027\u5355\u514b\u9686\u6297\u4f53\u5728\u4eba\u53d7\u8bd5\u8005\u4e2d\u7684\u52a8\u529b\u5b66\u6570\u636e\u3002<\/span><\/p>\n

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\u6765\u6e90\uff1a<\/strong>\u836f\u5b66\u4e0e\u4e34\u5e8a\u7814\u7a76 <\/strong>2018 <\/span>Aug;26(4)<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u672c\u6587\u5185\u5bb9\u7531\u51e1\u9ed8\u8c37\u5c0f\u7f16\u67e5\u9605\u6587\u732e\u9009\u53d6\uff0c\u6392\u7248\u4e0e\u7f16\u8f91\u4e3a\u539f\u521b\uff0c\u5982\u8f6c\u8f7d\uff0c\u8bf7\u6ce8\u660e\u6765\u6e90\u3002 \u4f5c\u8005\u89c2\u70b9\u4e0d\u4ee3\u8868\u672c\u516c\u4f17\u53f7\u7684\u89c2\u70b9\uff0c\u5982\u60a8\u5bf9 […]<\/p>\n","protected":false},"author":1,"featured_media":56933,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/56932"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=56932"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/56932\/revisions"}],"predecessor-version":[{"id":56937,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/56932\/revisions\/56937"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/56933"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=56932"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=56932"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=56932"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}