{"id":56941,"date":"2018-09-27T01:00:00","date_gmt":"2018-09-30T02:21:04","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e3%80%90%e5%bb%ba%e6%a8%a1%e6%96%87%e7%ab%a0%e8%a7%a3%e8%af%bb%e3%80%91%e7%bb%93%e5%90%88bottom-up%e5%92%8ctop-down%e7%9a%84%e6%96%b9%e6%b3%95%e8%af%84%e4%bc%b0\/"},"modified":"2018-09-30T10:21:07","modified_gmt":"2018-09-30T02:21:07","slug":"%e3%80%90%e5%bb%ba%e6%a8%a1%e6%96%87%e7%ab%a0%e8%a7%a3%e8%af%bb%e3%80%91%e7%bb%93%e5%90%88bottom-up%e5%92%8ctop-down%e7%9a%84%e6%96%b9%e6%b3%95%e8%af%84%e4%bc%b0","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/56941\/","title":{"rendered":"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section style=\"box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;text-align: center;box-sizing: border-box;\">\n<section style=\"padding: 1em;width: 100%;background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1538274067.png');background-repeat: no-repeat;background-size: 100% 100%;background-color: rgb(255, 129, 36);box-sizing: border-box;\">\n<section style=\"padding: 8px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"color: rgb(255, 255, 255);font-size: 20px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9<strong style=\"color: rgb(255, 255, 255);font-size: 20px;text-align: center;white-space: normal;background-color: rgb(255, 129, 36);box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u5339\u66ff\u5229\u53f8<\/span><\/strong>Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: left;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\u89e3\u8bfb\u4eba\uff1a\u51e1\u9ed8\u8c37&nbsp; \u4f55\u7ea2\u6885<br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"width: 5px;height: 2px;border-radius: 3px 3px 0px 0px;float: left;background-color: rgb(218, 203, 158);box-sizing: border-box;\"><\/section>\n<section style=\"width: 5px;height: 2px;border-radius: 3px 3px 0px 0px;float: right;background-color: rgb(218, 203, 158);box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"border-left: 5px solid rgb(218, 203, 158);border-right: 5px solid rgb(218, 203, 158);border-top-color: rgb(218, 203, 158);border-bottom-color: rgb(218, 203, 158);background-color: rgb(255, 129, 36);padding: 2px 10px;color: rgb(255, 255, 255);font-size: 18px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u63a8\u8350\u7406\u7531<\/strong><\/p>\n<\/section>\n<section style=\"box-sizing: border-box;\">\n<section style=\"width: 5px;height: 2px;border-radius: 0px 0px 3px 3px;float: left;background-color: rgb(218, 203, 158);box-sizing: border-box;\"><\/section>\n<section style=\"width: 5px;height: 2px;border-radius: 0px 0px 3px 3px;float: right;background-color: rgb(218, 203, 158);box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;line-height: 1.75em;\"><span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\">Genentech<\/span>\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u7ed3\u5408PopPK\u548cPBPK\u7684\u65b9\u6cd5\uff0c\u63ed\u793a\u5f31\u78b1\u6027\u5316\u5408\u7269<span style=\"text-align: justify;\">Pictilisib<\/span>\u5728\u4f53\u5185\u7684\u5438\u6536\u60c5\u51b5\uff0c\u63a2\u8ba8\u5f71\u54cd\u5f31\u78b1\u6027\u5316\u5408\u7269\u4f53\u5185\u6eb6\u51fa\u548c\u5438\u6536\u7684\u5173\u952e\u6027\u56e0\u7d20\uff0c\u4e3a\u5f31\u78b1\u6027\u5316\u5408\u7269\u7684\u4e34\u5e8a\u7528\u836f\u65b9\u6848\u7684\u5408\u7406\u8bbe\u8ba1\u63d0\u4f9b\u6307\u5bfc\u5efa\u8bae\u3002<\/p>\n<section class=\"V5\"  style=\"white-space: normal;box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"width: 5px;height: 2px;border-radius: 3px 3px 0px 0px;float: right;background-color: rgb(218, 203, 158);box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"padding: 2px 10px;border-left: 5px solid rgb(218, 203, 158);border-right: 5px solid rgb(218, 203, 158);border-top-color: rgb(218, 203, 158);border-bottom-color: rgb(218, 203, 158);background-color: rgb(255, 129, 36);color: rgb(255, 255, 255);font-size: 18px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong>\u539f\u6587\u4f5c\u8005<\/strong><\/p>\n<\/section>\n<section style=\"box-sizing: border-box;\">\n<section style=\"width: 5px;height: 2px;border-radius: 0px 0px 3px 3px;float: left;background-color: rgb(218, 203, 158);box-sizing: border-box;\"><\/section>\n<section style=\"width: 5px;height: 2px;border-radius: 0px 0px 3px 3px;float: right;background-color: rgb(218, 203, 158);box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"white-space: normal;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"margin:0cm;margin-bottom:.0001pt;\"><span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\">Tong Lu <sup>1<\/sup>, Grazyna Fraczkiewicz <sup>2<\/sup>, Laurent Salphati<sup> 3<\/sup>, Nageshwar Budha <sup>1<\/sup>, Gena Dalziel <sup>4<\/sup>, Gillian S. Smelick<sup>1<\/sup>, Kari M. Morrissey <sup>1<\/sup>,John D. Davis <sup>1<\/sup>, Jin Y. Jin <sup>1<\/sup>&nbsp;<o:p><\/o:p><\/span><\/p>\n<p style=\"margin: 0cm 0cm 0.0001pt;\"><span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\">1<\/span>\uff1a<span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\">Genentech<\/span>\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\uff0c\u4e34\u5e8a\u836f\u7406\u90e8\u95e8<span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\"><o:p><\/o:p><\/span><\/p>\n<p style=\"margin: 0cm 0cm 0.0001pt;\"><span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\">2<\/span>\uff1a\u7f8e\u56fd<span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\">Simulations Plus<\/span>\u516c\u53f8<span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\"><o:p><\/o:p><\/span><\/p>\n<p style=\"margin: 0cm 0cm 0.0001pt;\"><span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\">3<\/span>\uff1a<span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\">Genentech<\/span>\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\uff0c<span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\">DMPK<\/span>\u90e8\u95e8<span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\"><o:p><\/o:p><\/span><\/p>\n<p style=\"margin: 0cm 0cm 0.0001pt;\"><span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\">4<\/span>\uff1a<span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\">Genentech<\/span>\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\uff0c\u5c0f\u5206\u5b50\u836f\u7269\u79d1\u5b66\u90e8\u95e8<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"width: 5px;height: 2px;border-radius: 3px 3px 0px 0px;float: left;background-color: rgb(218, 203, 158);box-sizing: border-box;\"><\/section>\n<section style=\"width: 5px;height: 2px;border-radius: 3px 3px 0px 0px;float: right;background-color: rgb(218, 203, 158);box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"border-left: 5px solid rgb(218, 203, 158);border-right: 5px solid rgb(218, 203, 158);border-top-color: rgb(218, 203, 158);border-bottom-color: rgb(218, 203, 158);background-color: rgb(255, 129, 36);padding: 2px 10px;color: rgb(255, 255, 255);font-size: 18px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u6587\u732e\u6458\u8981<\/strong><\/p>\n<\/section>\n<section style=\"box-sizing: border-box;\">\n<section style=\"width: 5px;height: 2px;border-radius: 0px 0px 3px 3px;float: left;background-color: rgb(218, 203, 158);box-sizing: border-box;\"><\/section>\n<section style=\"width: 5px;height: 2px;border-radius: 0px 0px 3px 3px;float: right;background-color: rgb(218, 203, 158);box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;margin-bottom: 10px;line-height: 1.75em;\"><span lang=\"EN-US\" style=\"font-family: &quot;Times New Roman&quot;, serif;\">Genentech<\/span>\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u7814\u7a76\u4eba\u5458\u7ed3\u5408\u201cBottom-up\u201d\uff08PBPK\uff09\u548c\u201cTop-down\u201d\uff08PopPK\uff09\u7684\u5efa\u6a21\u65b9\u6cd5\uff0c\u6a21\u62df\u98df\u7269\u548c\u8d28\u5b50\u6cf5\u6291\u5236\u5242PPI\u5bf9\u5f31\u78b1\u6027\u5316\u5408\u7269Pictilisib\u4f53\u5185\u6eb6\u51fa\u548c\u5438\u6536\u7684\u5f71\u54cd\u3002\u901a\u8fc7PopPK\u53d1\u73b0\uff1a\u98df\u7269\u548c<span style=\"text-align: justify;\">\u8d28\u5b50\u6cf5\u6291\u5236\u5242<\/span>PPI\u662f\u5173\u952e\u7684\u534f\u53d8\u91cf\uff1b\u901a\u8fc7PBPK\u6a21\u578b\u53d1\u73b0\uff1aPictilisib\u5728\u4f53\u5185\u51fa\u73b0\u8fc7\u9971\u548c\u8d8b\u52bf\uff0c\u5e76\u4e14\u91c7\u7528\u80c3\u6392\u7a7a\u751f\u7406\u6a21\u578b\u53ef\u6210\u529f\u9884\u6d4b\u98df\u7269\u548c<span style=\"text-align: justify;\">\u8d28\u5b50\u6cf5\u6291\u5236\u5242<\/span>PPI\u5bf9Pictilisib\u5438\u6536\u7684\u5f71\u54cd\u3002\u8be5\u7814\u7a76\u7a81\u51fa\u4e86\u5e94\u7528\u4e24\u79cd\u5b9a\u91cf\u65b9\u6cd5\u89e3\u51b3\u5236\u836f\u4f01\u4e1a\u5728\u836f\u7269\u5f00\u53d1\u4e2d\u7684\u5173\u952e\u95ee\u9898\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;overflow: hidden;text-align: center;box-sizing: border-box;\">\n<section style=\"width: 2em;height: 2em;margin-right: auto;margin-left: auto;border-radius: 100%;background-color: rgb(255, 129, 36);line-height: 2em;color: rgb(255, 255, 255);font-size: 20px;box-sizing: border-box;max-width: 20% !important;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">1<\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -1em;margin-bottom: 1em;box-sizing: border-box;\">\n<section style=\"border-top: 1px solid rgb(255, 129, 36);width: 35%;float: left;box-sizing: border-box;\"><\/section>\n<section style=\"border-top: 1px solid rgb(255, 129, 36);width: 35%;float: right;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: center;font-size: 20px;color: rgb(255, 129, 36);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;margin-bottom: 10px;line-height: 1.75em;\">Pictilisib\u5c5e\u4e8e\u5f3a\u6548\u3001\u9009\u62e9\u6027PI3K\u6291\u5236\u5242\uff0c\u7528\u4e8e\u80bf\u7624\u75be\u75c5\u7684\u6cbb\u7597\uff1b\u8be5\u836f\u4e3a\u5f31\u78b1\u6027\u5316\u5408\u7269\uff0c\u6eb6\u89e3\u5ea6\u5177\u6709pH\u503c\u4f9d\u8d56\u6027\u3002\u5982\u8be5\u7c7b\u836f\u7269\u4e0e\u6539\u53d8\u80c3pH\u7684\u5316\u5408\u7269\uff08\u5982\u9178\u6027\u8fd8\u539f\u5242ARAs\u3001<span style=\"text-align: justify;\">\u8d28\u5b50\u6cf5\u6291\u5236\u5242<\/span>PPI\uff09\u8054\u5408\u7ed9\u836f\uff0c\u5219\u5f88\u53ef\u80fd\u4f1a\u53d1\u751f\u6f5c\u5728\u7684DDI\u98ce\u9669\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;margin-bottom: 10px;line-height: 1.75em;\">Pictilisib\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\u5177\u6709\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5728I\u671f\u8bd5\u9a8c\u60a3\u8005\u4f53\u5185\u5177\u6709\u5f88\u597d\u7684\u8010\u53d7\u6027\u3002\u672c\u7814\u7a76\u5c06\u57fa\u4e8ePictilisib\u7684\u4f53\u5916\u3001\u4e34\u5e8a\u524d\u3001\u4e34\u5e8a\u6570\u636e\uff0c\u5229\u7528PBPK\u6a21\u578b\u7814\u7a76\u98df\u7269\u548c\u8d28\u5b50\u6cf5\u6291\u5236\u5242PPI\u662f\u5982\u4f55\u5f71\u54cd\u5f31\u78b1\u6027\u5316\u5408\u7269\u7684\u4f53\u5185PK\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;overflow: hidden;text-align: center;box-sizing: border-box;\">\n<section style=\"width: 2em;height: 2em;margin-right: auto;margin-left: auto;border-radius: 100%;background-color: rgb(255, 129, 36);line-height: 2em;color: rgb(255, 255, 255);font-size: 20px;box-sizing: border-box;max-width: 20% !important;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">2<\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -1em;margin-bottom: 1em;box-sizing: border-box;\">\n<section style=\"border-top: 1px solid rgb(255, 129, 36);width: 35%;float: left;box-sizing: border-box;\"><\/section>\n<section style=\"border-top: 1px solid rgb(255, 129, 36);width: 35%;float: right;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: center;font-size: 20px;color: rgb(255, 129, 36);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5efa\u6a21\u6570\u636e\u4e0e\u5904\u7406<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 1;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\"><span style=\"width: 0px;display: inline-block;opacity: 0.6;border-left: 0.6em solid rgb(255, 129, 36);border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;box-sizing: border-box;\"> <\/span><span style=\"width: 0px;display: inline-block;border-left: 0.6em solid rgb(255, 129, 36);border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;box-sizing: border-box;\"> <\/span> <\/section>\n<section style=\"display: inline-block;vertical-align: top;line-height: 1.2;padding-left: 3px;font-size: 18px;color: rgb(255, 129, 36);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">2.1 Pictilisib\u5efa\u6a21\u76f8\u5173\u6570\u636e<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1538274065.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1538274065.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\"  \/><\/p>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 1;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\"><span style=\"width: 0px;display: inline-block;opacity: 0.6;border-left: 0.6em solid rgb(255, 129, 36);border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;box-sizing: border-box;\"> <\/span><span style=\"width: 0px;display: inline-block;border-left: 0.6em solid rgb(255, 129, 36);border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;box-sizing: border-box;\"> <\/span> <\/section>\n<section style=\"display: inline-block;vertical-align: top;line-height: 1.2;padding-left: 3px;font-size: 18px;color: rgb(255, 129, 36);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">2.2 \u5efa\u6a21\u53c2\u6570\u7684\u83b7\u53d6\u4e0e\u5904\u7406<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;margin-bottom: 10px;line-height: 1.75em;\">\u4eba\u4f53PK\u6570\u636e\u6765\u6e90\u4e8eI\u671f\u4e34\u5e8a\u5b9e\u6d4b\u6570\u503c\uff1b\u7406\u5316\u53c2\u6570\u90e8\u5206\u91c7\u7528\u5b9e\u6d4b\u6570\u636e\uff0c\u90e8\u5206\u57fa\u4e8eADMET Predictor\u8f6f\u4ef6\u8fdb\u884c\u9884\u6d4b\uff1b<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;margin-bottom: 10px;line-height: 1.75em;\">\u91c7\u7528PopPK\u5206\u6790\u65b9\u6cd5\u5bf9\u4e34\u5e8a\u4e2d31\u4f8b\u53d7\u8bd5\u8005\u7684\u836f\u65f6\u6570\u636e\u8fdb\u884c\u5206\u6790\uff0c\u53d1\u73b0\u98df\u7269\u548c<span style=\"text-align: justify;\">\u8d28\u5b50\u6cf5\u6291\u5236\u5242<\/span>PPI\u4e3a\u5173\u952e\u534f\u53d8\u91cf\u56e0\u7d20\uff1b<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;margin-bottom: 10px;line-height: 1.75em;\">\u91c7\u7528PBPK\u6a21\u578b\u8003\u5bdf<span style=\"text-align: justify;\">\u8d28\u5b50\u6cf5\u6291\u5236\u5242<\/span>PPI\u548c\u98df\u7269\u5bf9Pictilisib\u4eba\u4f53\u5185PK\u7684\u5f71\u54cd\uff0c\u5e76\u91c7\u7528\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u8fdb\u884c\u6a21\u578b\u7684\u9a8c\u8bc1\u4e0e\u4f18\u5316\uff1b<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;margin-bottom: 10px;line-height: 1.75em;\">\u5728PBPK\u6a21\u578b\u9a8c\u8bc1\u8fc7\u7a0b\u4e2d\uff0c\u8003\u8651Pictilisib\u5c5e\u4e8e\u5f31\u78b1\u6027\u5316\u5408\u7269\uff0c\u5f53\u4ece\u80c3\u8fdb\u5165\u5341\u4e8c\u6307\u80a0\u8fc7\u7a0b\u4e2d\uff0c\u7531\u4e8epH\u7684\u7a81\u53d8\uff0c\u836f\u7269\u4f1a\u51fa\u73b0\u8fc7\u9971\u548c\u73b0\u8c61\uff0c\u56e0\u6b64\u6c89\u6dc0\u65f6\u95f4\uff08\u9ed8\u8ba4900s\uff09\u91c7\u7528\u62df\u5408\u503c\uff08\u957f\u4e8e900s\uff09\uff1b\u540c\u65f6\u91c7\u7528Johnson\u6a21\u578b\u65b9\u7a0b\u63cf\u8ff0\u836f\u7269\u5728\u5404\u4e2a\u80a0\u6bb5\u7684\u6eb6\u51fa\u8fc7\u7a0b\uff0c\u540c\u65f6\u8c03\u6574\u7a7a\u8179\u548c\u9971\u8179\u72b6\u6001\u4e0b\u7684\u80c3\u4f20\u8f93\u65f6\u95f4\uff1b\u6839\u636e\u6587\u732e\u62a5\u9053\u6570\u636e\u8c03\u6574\u8d28\u5b50<span style=\"text-align: justify;\">\u6cf5\u6291\u5236\u5242<\/span>PPI\u7684\u5f71\u54cd\uff1b<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;margin-bottom: 10px;line-height: 1.75em;\">PBPK\u6a21\u578b\u5404\u7ec4\u7ec7\u7c7b\u578b\u4e3a\u8840\u6d41\u704c\u6ce8\u578b\uff0c\u809d\u6e05\u9664\u7387\uff085ml\/min\uff09\u662f\u57fa\u4e8e\u4f53\u5916\u5fae\u7c92\u4f53\u6570\u636e\u8f6c\u5316\u800c\u6765\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;overflow: hidden;text-align: center;box-sizing: border-box;\">\n<section style=\"width: 2em;height: 2em;margin-right: auto;margin-left: auto;border-radius: 100%;background-color: rgb(255, 129, 36);line-height: 2em;color: rgb(255, 255, 255);font-size: 20px;box-sizing: border-box;max-width: 20% !important;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">3<\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -1em;margin-bottom: 1em;box-sizing: border-box;\">\n<section style=\"border-top: 1px solid rgb(255, 129, 36);width: 35%;float: left;box-sizing: border-box;\"><\/section>\n<section style=\"border-top: 1px solid rgb(255, 129, 36);width: 35%;float: right;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: center;font-size: 20px;color: rgb(255, 129, 36);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u6a21\u578b\u7ed3\u679c\u4e0e\u5206\u6790<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 1;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\"><span style=\"width: 0px;display: inline-block;opacity: 0.6;border-left: 0.6em solid rgb(255, 129, 36);border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;box-sizing: border-box;\"> <\/span><span style=\"width: 0px;display: inline-block;border-left: 0.6em solid rgb(255, 129, 36);border-top: 0.5em solid transparent !important;border-bottom: 0.5em solid transparent !important;box-sizing: border-box;\"> <\/span> <\/section>\n<section style=\"display: inline-block;vertical-align: top;line-height: 1.2;padding-left: 3px;font-size: 18px;color: rgb(255, 129, 36);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">3.1 Pictilisib\u57fa\u7840PBPK\u6a21\u578b\u7684\u642d\u5efa\u4e0e\u9a8c\u8bc1<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1538274065.jpg\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;line-height: 1.75em;\">\u5206\u522b\u5efa\u7acb40mg Pictilisib\u7684Fed\u3001Fed+PPI\u3001Fasted\u3001Fasted+PPI\u56db\u7ec4PBPK\u6a21\u578b\uff0c\u9884\u6d4b\u66f2\u7ebf\u4e0e\u5b9e\u6d4b\u6570\u636e\u70b9\u80fd\u591f\u8f83\u597d\u7684\u543b\u5408\uff0c\u56db\u7ec4\u6a21\u578b\u9884\u6d4b\u7ed3\u679c\u7ed9\u51fa\u4e86\u5404\u81ea\u7684\u836f\u7269\u6eb6\u51fa\u3001\u5438\u6536\u767e\u5206\u6570\u53ca\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5982\u4e0b\u8868\u683c\u6240\u793a\uff1a<\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1538274065.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6a21\u578b\u7ed3\u679c\u63d0\u793a\uff1a\u7a7a\u8179\u72b6\u6001\u4e0b\uff0c<span style=\"text-align: justify;\">\u8d28\u5b50\u6cf5\u6291\u5236\u5242<\/span>PPI\u80fd\u591f\u663e\u8457\u964d\u4f4ePictilisib\u7684AUC\u548c<span style=\"font-size:14px;\">T<sub>max<\/sub><\/span>\uff0c\u800c\u98df\u7269\u53ef\u4ee5\u589e\u52a0Pictilisib\u7684AUC\u548c<span style=\"font-size:14px;\">T<sub>max<\/sub><\/span>\u3002<br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;overflow: hidden;text-align: center;box-sizing: border-box;\">\n<section style=\"width: 2em;height: 2em;margin-right: auto;margin-left: auto;border-radius: 100%;background-color: rgb(255, 129, 36);line-height: 2em;color: rgb(255, 255, 255);font-size: 20px;box-sizing: border-box;max-width: 20% !important;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">4<\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -1em;margin-bottom: 1em;box-sizing: border-box;\">\n<section style=\"border-top: 1px solid rgb(255, 129, 36);width: 35%;float: left;box-sizing: border-box;\"><\/section>\n<section style=\"border-top: 1px solid rgb(255, 129, 36);width: 35%;float: right;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: center;font-size: 20px;color: rgb(255, 129, 36);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u6a21\u578b\u5e94\u7528<br style=\"box-sizing: border-box;\"  \/><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u9884\u6d4b<span style=\"text-align: justify;\">\u8d28\u5b50\u6cf5\u6291\u5236\u5242<\/span>PPI\uff08\u96f7\u8d1d\u62c9\u5511\uff09\u5bf9Pictilisib\uff08340mg\uff09\u5728\u4e73\u817a\u764c\u60a3\u8005\u4f53\u5185\u6eb6\u51fa\u548c\u5438\u6536\u7684\u5f71\u54cd\uff0c\u5c06\u80c3\u4f20\u8f93\u65f6\u95f4\u5206\u522b\u8bbe\u5b9a\u4e3a\u4e0e\u5065\u5eb7\u4eba\u76f8\u540c\u3001\u65f6\u95f4\u4e3a\u5065\u5eb7\u4eba\u76842\u500d\uff0c\u6a21\u578b\u9884\u6d4b\u7ed3\u679c\u5982\u4e0b\uff1a<\/p>\n<\/section>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1538274066.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\"  \/><\/p>\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1538274066.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;margin-bottom: 10px;line-height: 1.75em;\">\u6a21\u578b\u7ed3\u679c\u63d0\u793a\uff1a\u764c\u75c7\u60a3\u8005\u56e0\u5176\u75be\u75c5\u548c\u6cbb\u7597\u7684\u5f71\u54cd\uff0c\u5e38\u4f1a\u51fa\u73b0\u80c3\u80a0\u9053\u52a8\u529b\u969c\u788d\u3002\u5c06\u4e73\u817a\u764c\u75c5\u4eba\u7684\u80c3\u4f20\u8f93\u65f6\u95f4\u8c03\u6574\u4e3a\u5065\u5eb7\u4eba\u76842\u500d\uff0c\u53ef\u4ee5\u663e\u8457\u6539\u5584\u836f\u7269\u5728\u4f53\u5185\u7684\u5438\u6536\u767e\u5206\u6570\uff0c\u5e76\u4e14\u5bf9\u9971\u8179\u72b6\u6001\u4e0b\u5438\u6536\u6539\u5584\u66f4\u4e3a\u660e\u663e\u3002\u5065\u5eb7\u4eba\u53e3\u670d40mg\u7684Pictilisib\uff0c\u5438\u6536\u53ef\u4ee5\u8fbe\u5230100%\uff0c\u800c\u5c06\u5242\u91cf\u63d0\u9ad8\u4e86340mg\u65f6\uff0c\u5219\u51fa\u73b0\u4f53\u5185\u5438\u6536\u4e0d\u5b8c\u5168\u7684\u73b0\u8c61\uff0c\u5438\u6536\u767e\u5206\u6570\u4e3a78%\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;overflow: hidden;text-align: center;box-sizing: border-box;\">\n<section style=\"width: 2em;height: 2em;margin-right: auto;margin-left: auto;border-radius: 100%;background-color: rgb(255, 129, 36);line-height: 2em;color: rgb(255, 255, 255);font-size: 20px;box-sizing: border-box;max-width: 20% !important;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">5<\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -1em;margin-bottom: 1em;box-sizing: border-box;\">\n<section style=\"border-top: 1px solid rgb(255, 129, 36);width: 35%;float: left;box-sizing: border-box;\"><\/section>\n<section style=\"border-top: 1px solid rgb(255, 129, 36);width: 35%;float: right;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: center;font-size: 20px;color: rgb(255, 129, 36);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u6a21\u578b\u8ba8\u8bba<br style=\"box-sizing: border-box;\"  \/><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;margin-bottom: 10px;line-height: 1.75em;\">\u6c89\u6dc0\u65f6\u95f4\u7684\u8c03\u6574\uff1a\u91c7\u7528PBPK\u6a21\u578b\u8868\u5f81Pictilisib\u5728\u5065\u5eb7\u4eba\u4f53\u5185\u7684PK\u884c\u4e3a\uff08\u5e73\u5747\u503c\uff09\uff0c\u56e0\u836f\u7269\u5c5e\u4e8e\u5f31\u78b1\u6027BCSII\u7c7b\u5316\u5408\u7269\uff0c\u5728\u80c3\u6db2pH\u503c\u8f83\u4f4e\uff08\u5982\u7a7a\u8179\u72b6\u6001\uff09\u65f6\uff0c\u6eb6\u89e3\u5ea6\u8f83\u9ad8\uff0c\u5316\u5408\u7269\u7684\u6eb6\u51fa\u548c\u6eb6\u89e3\u90fd\u6bd4\u8f83\u8fc5\u901f\uff1b\u4ece\u80c3\u8f6c\u79fb\u81f3\u5341\u4e8c\u6307\u80a0\u8fc7\u7a0b\u4e2d\uff0c\u7531\u4e8epH\u503c\u7a81\u53d8\uff0c\u836f\u7269\u4f1a\u51fa\u73b0\u8fc7\u9971\u548c\u72b6\u6001\uff08\u4f53\u5916\u5b9e\u9a8c\u8bc1\u5b9e\u6709\u8fc7\u9971\u548c\u8d8b\u52bf\uff0c\u800c\u975e\u6c89\u6dc0\u4e0b\u6765\uff09\uff0c\u56e0\u6b64\u6c89\u6dc0\u65f6\u95f4\u8c03\u657490000s\uff1b<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;margin-bottom: 10px;line-height: 1.75em;\"><span style=\"background-color: rgb(255, 218, 169);\"><strong><span style=\"background-color: rgb(255, 218, 169);text-align: justify;\">\u8d28\u5b50\u6cf5\u6291\u5236\u5242<\/span>PPI\u5bf9\u80c3\u5185pH\u503c\u7684\u5f71\u54cd\uff1a<\/strong><\/span><span style=\"text-align: justify;\">\u8d28\u5b50\u6cf5\u6291\u5236\u5242<\/span>PPI\u4e00\u822c\u4f1a\u9020\u6210\u7a7a\u8179\u72b6\u6001\u4e0b\u7684\u80c3\u5185pH\u503c\u5347\u9ad82-3\uff0cACAT\u5438\u6536\u6a21\u578b\u4e2d\uff0c\u7a7a\u8179\u4e0b\u7684pH\u4e3a1.5\uff1b\u52a0\u5165<span style=\"text-align: justify;\">\u8d28\u5b50\u6cf5\u6291\u5236\u5242<\/span>PPI\u540e\uff0c\u5c06pH\u503c\u8c03\u6574\u4e3a2.9\uff1b\u9971\u8179\u72b6\u6001\u4e0b\uff0c\u80c3\u5185pH\u503c\u4e3a4.9\uff1b\u52a0\u5165<span style=\"text-align: justify;\">\u8d28\u5b50\u6cf5\u6291\u5236\u5242<\/span>PPI\u540e\uff0cpH\u503c\u8c03\u6574\u4e3a5\uff1b\u4ee5\u4f7f\u5f97\u9884\u6d4b\u66f2\u7ebf\u8ddf\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u66f4\u52a0\u543b\u5408\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;margin-bottom: 10px;line-height: 1.75em;\"><span style=\"background-color: rgb(255, 218, 169);\"><strong>\u98df\u7269\u6548\u5e94\u6a21\u578b\u7684\u8003\u8651\uff1a<\/strong><\/span>\u7ed3\u5408\u65f6\u95f4\u4e0epH\u4f9d\u8d56\u6027\u80c3\u6392\u7a7a\u751f\u7406\u5b66\u7279\u5f81\uff0c\u5f53\u6444\u5165\u56fa\u4f53\u98df\u7269\u4e4b\u540e\uff0c\u80c3\u5185pH\u503c\u5347\u9ad8\u81f34\u5de6\u53f3\uff0c\u80c3\u5e7d\u95e8\u74e3\u5173\u95ed\uff0c\u80c3\u5185\u98df\u7269\u5f00\u59cb\u6d88\u5316\u3002\u5728\u8fd9\u671f\u95f4\uff0c\u6db2\u4f53\u548c\u76f4\u5f84\u5c0f\u4e8e1mm\u7684\u60ac\u6d6e\u5c0f\u9897\u7c92\u6d41\u5165\u5341\u4e8c\u6307\u80a0\uff1b\u800c\u8f83\u5927\u7684\u56fa\u4f53\u548c\u7c98\u6027\u7269\u8d28\u4ecd\u7559\u5728\u80c3\u5185\u4e0e\u80c3\u6db2\u8fdb\u4e00\u6b65\u6df7\u5300\u3002\u80c3\u5185\u98df\u7269\u5b8c\u5168\u6392\u7a7a\u65f6\u95f4\u4e3a4-6h\uff0c\u5728\u6b64\u671f\u95f4\uff0c\u968f\u7740\u98df\u7269\u7684\u9010\u6b65\u6d88\u5316\uff0c\u80c3\u5185pH\u503c\u5f00\u59cb\u4e0b\u964d\u3002\u5f53pH\u503c\u4f4e\u4e8e4\u65f6\uff0c\u80c3\u5e7d\u95e8\u6253\u5f00\uff0c\u98df\u7269\u8fdb\u5165\u5c0f\u80a0\uff0c\u5f00\u59cb\u540e\u7eed\u7684\u5438\u6536\u7b49\u8fc7\u7a0b\u3002\u91c7\u7528PBPK\u8003\u5bdf\u98df\u7269\u6548\u5e94\u5bf9Pictilisib PK\u7684\u5f71\u54cd\uff0c\u57fa\u4e8e\u80c3\u6392\u7a7a\u751f\u7406\u5b66\u7279\u5f81\uff0c\u8c03\u6574\u80c3\u6392\u7a7a\u65f6\u95f4\u7684\u80c3\u5185pH\u503c\u548c\u4f20\u8f93\u65f6\u95f4\uff0c\u4ece\u800c\u53ef\u4ee5\u66f4\u597d\u5730\u8868\u5f81Pictilisib\u5728\u4f53\u5185\u6eb6\u51fa\u548c\u5438\u6536\u8fc7\u7a0b\uff0c\u5177\u4f53\u7684\u53c2\u6570\u8c03\u6574\u5982\u4e0b\uff1a<\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1538274066.png\" alt=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\" title=\"\u3010\u5efa\u6a21\u6587\u7ae0\u89e3\u8bfb\u3011\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9Pictilisib\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;line-height: 1.75em;margin-bottom: 10px;\">\u901a\u8fc7\u4f4e\u5242\u91cf\uff0840mg\uff09PK\u6a21\u578b\uff0c\u9884\u6d4b\u9ad8\u5242\u91cf\uff08340mg\uff09\u7684\u4f53\u5185\u5438\u6536\u60c5\u51b5\uff0c\u5e76\u9610\u660e\u9ad8\u5242\u91cf\u4e0b\u836f\u7269\u5b58\u5728\u5438\u6536\u4e0d\u5b8c\u5168\u7684\u73b0\u8c61\uff0c\u4e5f\u4e3a\u4e34\u5e8a\u4e0a\u836f\u7269\u5242\u91cf\u7684\u8bbe\u5b9a\u63d0\u4f9b\u4e00\u5b9a\u7684\u6307\u5bfc\u610f\u4e49\uff1bPBPK\u6a21\u578b\u5728\u8be5\u836f\u7269\u4e0a\u7684\u6210\u529f\u5b9e\u65bd\uff0c\u5e76\u4e14\u53ef\u4ee5\u91c7\u7528\u8be5\u6a21\u578b\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u5e94\u7528\uff0c\u4e3a\u9884\u6d4b\u98df\u7269\u6548\u5e94\u548cPPI\u5bf9\u5f31\u78b1\u6027\u5316\u5408\u7269\u7684\u5438\u6536\u5f71\u54cd\u63d0\u4f9b\u4e00\u79cd\u65b0\u601d\u8def\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;overflow: hidden;text-align: center;box-sizing: border-box;\">\n<section style=\"width: 2em;height: 2em;margin-right: auto;margin-left: auto;border-radius: 100%;background-color: rgb(255, 129, 36);line-height: 2em;color: rgb(255, 255, 255);font-size: 20px;box-sizing: border-box;max-width: 20% !important;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">5<\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -1em;margin-bottom: 1em;box-sizing: border-box;\">\n<section style=\"border-top: 1px solid rgb(255, 129, 36);width: 35%;float: left;box-sizing: border-box;\"><\/section>\n<section style=\"border-top: 1px solid rgb(255, 129, 36);width: 35%;float: right;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: center;font-size: 20px;color: rgb(255, 129, 36);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u603b\u7ed3<br style=\"box-sizing: border-box;\"  \/><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;margin-bottom: 10px;line-height: 2em;\">\u672c\u6b21\u7814\u7a76\u91c7\u7528GastroPlus\u6a21\u62df\u98df\u7269\u548c<span style=\"text-align: justify;\">\u8d28\u5b50\u6cf5\u6291\u5236\u5242<\/span>PPI\u5bf9Pictilisib\u4f53\u5185\u5438\u6536\u7684\u5f71\u54cd\uff0c\u901a\u8fc7\u6a21\u62df\u7684\u624b\u6bb5\uff0c\u63ed\u793a\u98df\u7269\u6548\u5e94\u7684\u5185\u5728\u4f5c\u7528\u673a\u5236\uff0c\u5e76\u4e14\u6a21\u62df\u7ed3\u679c\u4e0e\u4e34\u5e8a\u5b9e\u6d4b\u6570\u636e\u543b\u5408\uff0c\u4e5f\u8fdb\u4e00\u6b65\u589e\u5f3a\u8bbe\u7f6e\u4e34\u5e8a\u7ed9\u836f\u65b9\u6848\u7684\u4fe1\u5fc3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;overflow: hidden;text-align: center;box-sizing: border-box;\">\n<section style=\"width: 2em;height: 2em;margin-right: auto;margin-left: auto;border-radius: 100%;background-color: rgb(255, 129, 36);line-height: 2em;color: rgb(255, 255, 255);font-size: 20px;box-sizing: border-box;max-width: 20% !important;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">6<\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -1em;margin-bottom: 1em;box-sizing: border-box;\">\n<section style=\"border-top: 1px solid rgb(255, 129, 36);width: 35%;float: left;box-sizing: border-box;\"><\/section>\n<section style=\"border-top: 1px solid rgb(255, 129, 36);width: 35%;float: right;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: center;font-size: 20px;color: rgb(255, 129, 36);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5e94\u7528\u8f6f\u4ef6\u4e0e\u6a21\u5757<br style=\"box-sizing: border-box;\"  \/><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;margin-bottom: 10px;line-height: 1.75em;\">\u8be5\u6848\u4f8b\u5e94\u7528\u7684\u8f6f\u4ef6\u662fGastroPlus (version 9.0)\uff0c\u6d89\u53ca\u6a21\u5757\u6709Base, PBPK, Optimization, ADMET Predictor\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"font-size: 18px;color: rgb(255, 129, 36);box-sizing: border-box;\">\u53c2\u8003\u6587\u732e<\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"box-sizing: border-box;\"><\/span><\/p>\n<p style=\"box-sizing: border-box;\">Lu T, Fraczkiewicz G, Salphati L, Budha N, Dalziel G, Smelick GS, Morrissey KM, Davis JD, Jin JY, Ware JA. Combining \u201cBottom-up\u201d and \u201cTop-down\u201d Approaches to Assess the Impact of Food and Gastric pH on Pictilisib (GDC-0941) Pharmacokinetics. CPT Pharmacometrics Syst Pharmacol. 2017 Nov; 6 (11): 747-755.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<span style=\"color: rgb(0, 209, 0);\"> IF=6.544&nbsp; Cite Score: 3.00<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;widows: 1;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;border-width: 8px 1px 1px;border-style: solid;border-color: rgb(255, 129, 36) rgb(204, 204, 204) rgb(204, 204, 204);box-shadow: rgb(204, 204, 204) 0px 0px 8px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"padding: 5px 10px;max-width: 100%;font-size: 24px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5c0f\u8d34\u58eb<\/strong><\/section>\n<section style=\"padding: 10px;max-width: 100%;border-top: 1px solid rgb(204, 204, 204);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"margin-bottom: 10px;max-width: 100%;box-sizing: border-box;min-height: 1em;font-size: 15px;line-height: 1.75em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u51e1\u9ed8\u8c37\u516c\u4f17\u53f7\u5f00\u901a\u5f80\u671f\u6587\u7ae0\u4efb\u610f\u641c\u529f\u80fd\u5566<\/span><\/strong><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-bottom: 10px;max-width: 100%;min-height: 1em;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u516c\u4f17\u53f7\u83dc\u5355\u680f\u4e2d\u8f93\u5165\u201c\u641c\u7d22\u201d\uff0c\u5373\u53ef\u641c\u7d22\u5f80\u671f\u5fae\u4fe1\u5185\u5bb9<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;font-size: 19.2px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;border-bottom: 2px solid rgb(255, 129, 36);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u4e0b\u8f7d\u82f1\u6587\u6587\u732e\u539f\u6587<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 44.625px;margin-left: 44.625px;max-width: 100%;box-sizing: border-box;line-height: 1.1em;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;width: 0px;display: inline-block;vertical-align: top;border-top: 1em solid rgb(255, 129, 36);word-wrap: break-word !important;border-left: 0.8em solid transparent !important;border-right: 0.8em solid transparent !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7ed3\u5408\u201cBottom-up\u201d\u548c\u201cTop-down\u201d\u7684\u65b9\u6cd5\u8bc4\u4f30\u98df\u7269\u548c\u80c3\u5185pH\u503c\u5bf9\u5339\u66ff\u5229\u53f8Pictilisib\u836f\u4ee3\u52a8 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":56942,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/56941"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=56941"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/56941\/revisions"}],"predecessor-version":[{"id":56951,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/56941\/revisions\/56951"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/56942"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=56941"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=56941"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=56941"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}