{"id":57045,"date":"2018-09-28T01:00:00","date_gmt":"2018-09-30T02:22:13","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e9%aa%84%e5%82%b2%ef%bc%81%e5%8e%86%e6%97%b640%e5%b9%b4%ef%bc%8c%e8%b7%a8%e5%9b%bd%e5%b7%a8%e5%a4%b4%e6%94%be%e5%bc%83%ef%bc%8c%e8%bf%99%e5%ae%b6%e4%b8%ad%e5%9b%bd%e8%8d%af%e4%bc%81%e5%9d%9a%e6%8c%81\/"},"modified":"2018-09-30T10:22:19","modified_gmt":"2018-09-30T02:22:19","slug":"%e9%aa%84%e5%82%b2%ef%bc%81%e5%8e%86%e6%97%b640%e5%b9%b4%ef%bc%8c%e8%b7%a8%e5%9b%bd%e5%b7%a8%e5%a4%b4%e6%94%be%e5%bc%83%ef%bc%8c%e8%bf%99%e5%ae%b6%e4%b8%ad%e5%9b%bd%e8%8d%af%e4%bc%81%e5%9d%9a%e6%8c%81","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/57045\/","title":{"rendered":"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e"},"content":{"rendered":"
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\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"<\/p>\n

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\u535a\u96c5\u5929\u4e0b\u65d7\u4e0b\u4ea7\u54c1<\/span><\/strong><\/span><\/p>\n

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\u4e0d\u53ef\u5426\u8ba4\uff0c\u539f\u521b\u65b0\u836f\u7814\u53d1\u662f\u4e00\u4e2a\u5904\u5904\u58c1\u5792\u7684\u95ef\u5173\u6e38\u620f\uff0c\u6bcf\u4e2a\u53c2\u4e0e\u7684\u201c\u73a9\u5bb6\u201d\u65e0\u4e0d\u63d0\u5fc3\u540a\u80c6\u3001\u5982\u5c65\u8584\u51b0\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u56e0\u5176\u6295\u5165\u5927\u3001\u5468\u671f\u957f\uff0c\u5e38\u5e38\u88ab\u4eba\u79f0\u4e4b\u4e3a\u201c\u767e\u6b7b\u4e00\u751f\u201d \u7684\u4e8b\u4e1a\u3002<\/p>\n


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\u4e0b\u9762\uff0c\u6211\u4eec\u4e00\u8d77\u6765\u91cd\u6e29\u8fd9\u6bb5\u7cbe\u5f69\u7684\u5386\u53f2\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f5c\u8005 <\/span>| <\/span>\u5065\u8bc6\u5c40\u6574\u7406<\/span><\/p>\n

\u6765\u6e90 | <\/span>Dr.Why<\/span>
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\u5168\u6587<\/span>2688<\/span><\/strong>\u5b57<\/span><\/strong>\uff0c\u9605\u8bfb\u9700<\/span>5<\/span><\/strong><\/span>\u5206\u949f<\/span><\/strong><\/p>\n


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\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"<\/p>\n


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\u4e0d\u8fc7\u8bdd\u8bf4\u56de\u6765\uff0c\u522b\u770b\u8840\u5c0f\u677f\u957f\u5f97\u5c0f\uff0c\u4f46\u4e5f\u662f\u6211\u4eec\u4eba\u4f53\u8840\u6db2\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u638c\u7ba1\u7740\u4eba\u4f53\u8840\u6db2\u7684\u6b62\u8840\u548c\u51dd\u8840\u529f\u80fd<\/strong>\u3002\u6240\u4ee5\u4e00\u65e6\u8840\u5c0f\u677f\u51cf\u5c11\uff0c\u5c31\u4f1a\u7ed9\u6211\u4eec\u5e26\u6765\u4e00\u7cfb\u5217\u7684\u95ee\u9898\uff0c\u4e25\u91cd\u65f6\u8fd8\u4f1a\u5371\u53ca\u751f\u547d\u3002<\/span><\/p>\n


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\u5982\u679c\u8fd9\u79cd\u60c5\u51b5\u53d1\u751f\u5728\u767e\u5e74\u524d\uff0c\u6216\u8bb8\u6211\u4eec\u53ea\u80fd\u5b89\u9759\u5730\u7b49\u6b7b\u4e86\uff0c\u4f46\u751f\u6d3b\u572821\u4e16\u7eaa\u7684\u6211\u4eec\u5f88\u5e78\u8fd0\uff0c\u56e0\u4e3a\u6211\u4eec\u9047\u5230\u4e86\u91cd\u7ec4\u4eba\u8840\u5c0f\u677f\u751f\u6210\u7d20\uff08rhTPO\uff09\uff0c\u800c\u5b83\u7684\u51fa\u73b0\u4e5f\u7ed9\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u7684\u60a3\u8005\u5e26\u6765\u4e86\u8bb8\u591a\u798f\u97f3\u3002<\/span><\/p>\n


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\u636e\u4e09\u751f\u5236\u836f\u96c6\u56e22018\u5e74\u534a\u5e74\u62a5\u663e\u793a\uff0c\u7279\u6bd4\u6fb3\u7684\u5e02\u573a\u4efd\u989d\u8fbe\u523063.2%\uff0c\u5e76\u53d6\u5f9710.1%\u7684\u9500\u552e\u589e\u957f\uff0c\u7eb3\u51652017\u5e74\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u4e59\u7c7b\u836f\u7269\uff0c\u88ab\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u4f20\u7edf\u6027\u9aa8\u8089\u7624\u8bca\u7597\u6307\u5357\u5217\u5165\u5316\u7597\u5f15\u8d77\u7684\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff08CIT\uff09\u7684\u4e3b\u8981\u7597\u6cd5\u4e4b\u4e00\u3002<\/span><\/p>\n


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\u636e\u4e0d\u5b8c\u5168\u7edf\u8ba1\uff0c\u7279\u6bd4\u6fb3\u5df2\u6551\u6cbb\u4e86\u6210\u5343\u4e0a\u4e07\u540d\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u60a3\u8005\u7684\u751f\u547d\u3002\u6709\u4eba\u4e0d\u7981\u8981\u95ee\uff0c\u8fd9\u5230\u5e95\u662f\u4e00\u6b3e\u4ec0\u4e48\u6837\u7684\u521b\u65b0\u836f\u5462\uff1f<\/span><\/p>\n


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\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u5c31\u6765\u8bb2\u4e00\u8bb2\u7279\u6bd4\u6fb3\u7684\u7814\u53d1\u6545\u4e8b\u3002<\/span><\/p>\n


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19\u4e16\u7eaa60\u5e74\u4ee3\uff0cBizzozero\u7528\u663e\u5fae\u955c\u5728\u8840\u6db2\u4e2d\u89c2\u5bdf\u5230\u4e86\u4e00\u79cd\u5947\u7279\u7684\u5fae\u5c0f\u201c\u7c92\u5b50\u201d[1]\u3002<\/span><\/p>\n


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\u4e3a\u4ec0\u4e48\u8bf4\u5b83\u5947\u7279\u5462\uff1f<\/span><\/p>\n


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\u9996\u5148\u662f\u56e0\u4e3a\u8fd9\u79cd\u201c\u7c92\u5b50\u201d\u7684\u201c\u4f53\u578b\u201d\u4e0e\u666e\u901a\u7684\u7ea2\u3001\u767d\u7ec6\u80de\u4e0d\u4e00\u6837\uff0c\u9664\u4e86\u957f\u5f97\u5947\u5947\u602a\u602a\u5f62\u72b6\u4e0d\u89c4\u5219<\/strong>\u4e4b\u5916\uff0c\u201c\u7c92\u5b50\u201d\u7684\u4e2a\u5934\u4e5f\u6bd4\u8f83\u5c0f\uff0c\u4e00\u822c\u76f4\u5f84\u57282-4\u03bcm<\/strong>\u3002\u56e0\u4e3a\u5728\u663e\u5fae\u955c\u4e0b\u5f88\u96be\u5206\u8fa8\uff0c\u6240\u4ee5\u53c8\u88ab\u79f0\u4e3a\u201c\u8840\u7684\u5c18\u57c3\u201d\u3002<\/span><\/p>\n


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\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"<\/span><\/p>\n


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\u806a\u660e\u7684Bizzozero\u81ea\u7136\u77e5\u9053\u8fd9\u662f\u6b62\u8840\u8fc7\u7a0b\u4e86\uff0c\u53ef\u662f\u8fd9\u5fae\u5c0f\u7684\u201c\u7c92\u5b50\u201d\u7a76\u7adf\u662f\u4f55\u65b9\u795e\u5723\u5462\uff0c\u5c45\u7136\u80fd\u6709\u8fd9\u4e48\u5927\u7684\u672c\u4e8b\u53ef\u4ee5\u8d77\u5230\u6b62\u8840\u7684\u4f5c\u7528\uff1f\u867d\u7136\u6700\u540eBizzozero\u6ca1\u6316\u6e05\u695a\u201c\u7c92\u5b50\u201d\u7684\u7956\u5b97\u4e09\u4ee3\uff0c\u4f46Bizzozero\u5374\u7ed9\u5b83\u8d77\u4e86\u4e00\u4e2a\u540d\u5b57\uff0c\u53eb\u8840\u5c0f\u677f\uff08platelet\uff09<\/strong>[2]\u3002<\/span><\/p>\n


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1906\u5e74\uff0c\u4e00\u4e2a\u53eb\u540dJames Homer Wright\u7684\u7f8e\u56fd\u75c5\u7406\u5b66\u5bb6\u63a5\u624b\u4e86\u201c\u5228\u575f\u201d\u7684\u5de5\u4f5c\uff0c\u67e5\u6e05\u4e86\u8840\u5c0f\u677f\u7684\u8eab\u4e16\u3002<\/span><\/p>\n


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Wright\u5728\u663e\u5fae\u955c\u4e0b\u89c2\u5bdf\u5230\u8840\u5c0f\u677f\u4e0e\u9aa8\u9ad3\u91cc\u5de8\u6838\u7ec6\u80de\u6709\u7740\u76f8\u540c\u7684\u7740\u8272\u6027\u8d28\uff0c\u8fd9\u4e0d\u5c31\u662f\u8bf4\u8840\u5c0f\u677f\u8ddf\u9aa8\u9ad3\u5de8\u6838\u7ec6\u80de\u672c\u662f\u4e00\u5bb6\u4eba\u561b\uff0c\u53e6\u5916\u8840\u6db2\u53c8\u6765\u6e90\u4e8e\u9aa8\u9ad3\uff0c\u770b\u6765\u8840\u5c0f\u677f\u6765\u6e90\u4e8e\u5de8\u6838\u7ec6\u80de<\/strong>\u662f\u65e0\u7591\u7684\u4e86\u3002\u4e0d\u4ec5\u5982\u6b64\uff0cWright\u8fd8\u7528\u5b9e\u9a8c\u8bc1\u660e\u4e86\u8840\u5c0f\u677f\u51cf\u5c11\u4e0e\u51fa\u8840\u6709\u5173<\/strong>[3-5]\u3002<\/span><\/p>\n


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\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"<\/span><\/p>\n

\u25b2 Wright\u53c2\u7167\u76f8\u673a\u7167\u7247\u6240\u7ed8\u7684\u753b<\/span><\/p>\n


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\u4e0e\u6b64\u540c\u65f6\uff0c\u4e0eWright\u540c\u5728\u9a6c\u585e\u8bf8\u8428\u5dde\u7efc\u5408\u533b\u9662\u7684\u53e6\u4e00\u540d\u5e74\u8f7b\u533b\u751fWilliam Duke\u4e5f\u6ca1\u95f2\u7740\uff0cDuke\u5728\u533b\u9662\u5f00\u5c55\u4e86\u4e00\u9879\u5c0f\u578b\u4eba\u4f53\u8bd5\u9a8c[6]\u3002<\/span><\/p>\n


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Duke\u7528\u52a8\u9759\u8109\u63d2\u7ba1\u6280\u672f\u5bf93\u540d\u60a3\u6709\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u7684\u53d7\u8bd5\u8005\u7ed9\u4e88\u5168\u8840\u8f93\u8840\u6cbb\u7597\uff0c\u7b80\u5355\u6765\u8bf4\u5c31\u662f\u628a\u5065\u5eb7\u8005\u8eab\u4e0a\u7684\u8840\u6db2\u8f93\u5230\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u7684\u60a3\u8005\u8eab\u4e0a\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8bd5\u9a8c\u7ed3\u679c\u5982\u4f55\u5462\uff1f\u6ca1\u60f3\u5230\u8fd8\u633a\u51fa\u4eba\u610f\u6599\uff0c3\u4f4d\u53d7\u8bd5\u8005\u7684\u8840\u5c0f\u677f\u6570\u91cf\u5728\u8f93\u8840\u540e\u90fd\u51fa\u73b0\u4e86\u4e0d\u540c\u7a0b\u5ea6\u7684\u77ed\u6682\u56de\u5347\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4e0d\u8fc7\u56de\u5347\u7684\u539f\u56e0\u662f\u4ec0\u4e48\u5462\uff0cDuke\u5e76\u4e0d\u77e5\u9053\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u51e0\u5e74\u4e4b\u540e\uff0c\u4e5f\u5c31\u662f1919\u5e74\uff0c\u4e00\u4e2a\u540d\u53ebGeorge Minot\uff081934\u5e74\u56e0\u53d1\u73b0\u7ef4\u751f\u7d20B12\u800c\u83b7\u5f97\u8bfa\u8d1d\u5c14\u5956\uff09\u7684\u5e74\u8f7b\u533b\u751f\u5728\u8fdb\u884c\u4e86\u5927\u91cf\u7d2b\u765c\u6027\u51fa\u8840\u7684\u7814\u7a76\u540e\uff0c\u63d0\u51fa\u4e86\u8840\u5c0f\u677f\u51cf\u5c11\u7684\u4e24\u79cd\u5047\u8bbe[7]\uff1a\u4e00\u662f\u4f53\u5185\u5b58\u5728\u7279\u5b9a\u7684\u6bd2\u7269\uff0c\u4e00\u65e6\u8840\u5c0f\u677f\u5f62\u6210\uff0c\u6bd2\u7269\u5c31\u4f1a\u4ee5\u6700\u5feb\u7684\u901f\u5ea6\u5c06\u8840\u5c0f\u677f\u7834\u574f\u6389\uff1b\u4e8c\u662f\u5de8\u6838\u7ec6\u80de\u5728\u5f62\u6210\u8840\u5c0f\u677f\u7684\u8fc7\u7a0b\u4e2d\u7531\u4e8e\u53d7\u5230\u6bd2\u6027\u53cd\u5e94\u800c\u9020\u6210\u8840\u5c0f\u677f\u53d1\u80b2\u4e0d\u826f\u3002<\/strong><\/span><\/p>\n


<\/span><\/p>\n

\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"<\/span><\/p>\n

\u25b2 \u63d2\u753b\uff1a\u5947\u70b9\u63d2\u753b\u5e08\u738b\u723d<\/span><\/p>\n


<\/span><\/p>\n

Minot\u7684\u5047\u8bbe\u5927\u5927\u6fc0\u53d1\u4e86\u5176\u4ed6\u79d1\u5b66\u5bb6\u5bf9\u8840\u5c0f\u677f\u7684\u7814\u7a76\uff0c\u4eba\u4eec\u4e5f\u7eb7\u7eb7\u63d0\u51fa\u8d28\u7591\uff0c\u4f1a\u4e0d\u4f1a\u8fd8\u6709\u5176\u4ed6\u7684\u539f\u56e0\u5462\uff1f\u5f53\u7136\u8fd9\u9700\u8981\u65f6\u95f4\u7684\u8003\u8bc1\u3002<\/span><\/p>\n


<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

TPO\u4ece\u6982\u5ff5\u53d8\u6210\u73b0\u5b9e<\/span><\/p>\n<\/section>\n<\/section>\n


<\/p>\n<\/section>\n

\n
\n
\n

\u4ece1910\u5e74\u5f00\u59cb\uff0c\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u5927\u91cf\u7684\u4eba\u4f53\u751f\u7406\u5b66\u89c2\u5bdf\u53d1\u73b0\u4e86\u8840\u5c0f\u677f\u7684\u4e00\u4e9b\u79d8\u5bc6\u3002\u6bd4\u5982\uff0c\u5728\u6ca1\u6709\u4efb\u4f55\u75be\u75c5\u7684\u60c5\u51b5\u4e0b\uff0c\u8840\u5c0f\u677f\u7684\u6570\u91cf\u5728\u4efb\u4f55\u4e2a\u4f53\u4e2d\u90fd\u662f\u4fdd\u6301\u76f8\u5bf9\u7a33\u5b9a\u7684[8,9]\uff1b\u518d\u6bd4\u5982\uff0c\u5065\u5eb7\u7684\u4e2a\u4f53\u4e4b\u95f4\u8840\u5c0f\u677f\u7684\u6570\u91cf\u4e5f\u5e76\u4e0d\u662f\u5b8c\u5168\u76f8\u540c\u800c\u662f\u53d8\u5316\u5f88\u5927\uff08140\u00d7109\/L -450\u00d7109\/L\uff09[10]\u2026\u2026<\/span><\/p>\n


<\/span><\/p>\n

\u800c\u8fd9\u4e9b\u79cd\u79cd\u7ed3\u679c\u4e5f\u90fd\u5728\u8868\u660e\u7740\u4e00\u79cd\u53ef\u80fd\uff1a\u8840\u5c0f\u677f\u7684\u751f\u6210\u6216\u8bb8\u662f\u53d7\u67d0\u4e9b\u56e0\u7d20\u8c03\u8282\u7684<\/strong>\u3002\u4e0d\u8fc7\u201c\u53ef\u80fd\u201d\u7ec8\u5f52\u53ea\u662f\u4e00\u79cd\u731c\u6d4b\u800c\u5df2\uff0c\u600e\u4e48\u627e\u5230\u5b83\uff0c\u5374\u662f\u4e00\u4e2a\u503c\u5f97\u601d\u8003\u7684\u95ee\u9898\u3002<\/span><\/p>\n


<\/span><\/p>\n

1948\u5e74\uff0c\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\uff08EPO\uff09\u7684\u53d1\u73b0\u7ed9\u8bd5\u56fe\u5bfb\u627e\u8c03\u8282\u8840\u5c0f\u677f\u751f\u6210\u7684\u79d1\u5b66\u5bb6\u4eec\u5e26\u6765\u4e86\u4e00\u4e1d\u5e0c\u671b<\/span><\/strong>\u3002\u65e2\u7136\u8840\u6db2\u4e2d\u5b58\u5728\u4e00\u79cd\u8c03\u8282\u7ea2\u7ec6\u80de\u751f\u6210\u7684EPO\uff0c\u90a3\u662f\u4e0d\u662f\u540c\u6837\u4e5f\u5b58\u5728\u4e00\u79cd\u8c03\u8282\u8840\u5c0f\u677f\u751f\u6210\u7684\u56e0\u5b50\u5462\uff1f<\/span><\/p>\n


<\/p>\n

\u5c31\u5728\u5927\u5bb6\u5f88\u4e0d\u786e\u5b9a\u7684\u65f6\u5019\uff0c1958\u5e74\u4e00\u4f4d\u53ebEndre Kelemen\u7684\u5308\u7259\u5229\u8840\u6db2\u5b66\u5bb6\u7ad9\u4e86\u51fa\u6765\uff0c\u4fe1\u8a93\u65e6\u65e6\u5730\u5ba3\u5e03\u4e86\u8840\u6db2\u4e2d\u4e00\u5b9a\u5b58\u5728\u4e00\u79cd\u8c03\u8282\u8840\u5c0f\u677f\u751f\u6210\u7684\u4fc3\u8840\u5c0f\u677f\u751f\u6210\u7d20\uff08TPO\uff09<\/strong>[11]\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"<\/span><\/p>\n

\u25b2 Endre Kelemen<\/span><\/p>\n


<\/span><\/p>\n

\u4e0d\u8fc7\u8981\u600e\u4e48\u627e\u5230\u5b83\u5462\uff1f<\/span><\/p>\n


<\/span><\/p>\n

\u8fd9\u5728\u79d1\u5b66\u5bb6\u4eec\u770b\u6765\u5e76\u4e0d\u662f\u4ec0\u4e48\u4e16\u7eaa\u5927\u96be\u9898\uff0c\u6bd5\u7adfEPO\u7684\u63d0\u7eaf\u65b9\u6cd5\u5df2\u7ecf\u6446\u5728\u90a3\u91cc\u4e86\u561b\u3002\u65e2\u7136\u4e24\u8005\u540c\u6837\u5b58\u5728\u4e8e\u8840\u6db2\u91cc\uff0c\u53c8\u540c\u6837\u4e3a\u4fc3\u8840\u751f\u6210\u56e0\u5b50\uff0c\u90a3\u6309\u7167\u63d0\u7eafEPO\u65b9\u6cd5\u6765\u63d0\u7eafTPO\u4e0d\u5c31\u884c\u4e86\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u53ef\u60dc\u5929\u4e0d\u5982\u4eba\u613f\uff0c\u63d0\u7eafTPO\u7684\u5de5\u4f5c\u5e76\u6ca1\u6709\u4ed6\u4eec\u60f3\u50cf\u7684\u90a3\u4e48\u7b80\u5355\uff01\u4ece\u52a8\u7269\u7684\u5c3f\u6db2\u91cc\u63d0\u53d6\u4e86\u591a\u6b21\u4e4b\u540e\uff0c\u79d1\u5b66\u5bb6\u4eec\u6700\u7ec8\u90fd\u5931\u8d25\u4e86[12]\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8fd9\u5230\u5e95\u662f\u600e\u4e48\u56de\u4e8b\u5462\uff1f\u96be\u9053\u79d1\u5b66\u5bb6\u4eec\u7684\u60f3\u6cd5\u9519\u4e86\uff1f\u8fd9\u5bf9\u4e8e\u4ed6\u4eec\u6765\u8bf4\u4e5f\u662f\u767e\u601d\u4e0d\u5f97\u5176\u89e3\u7684\u95ee\u9898\u3002\u4e0d\u8fc7\u73b0\u5728\u770b\u6765\uff0c\u8fd9\u4e9b\u73b0\u8c61\u5e76\u4e0d\u96be\u89e3\u91ca\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u9996\u5148\uff0c\u809d\u810f\u624d\u662f\u4ea7\u751fTPO\u7684\u4e3b\u8981\u90e8\u4f4d<\/strong>\uff0c\u867d\u7136\u80be\u810f\u4e5f\u80fd\u4ea7\u751f\uff0c\u4f46\u662f\u6bd5\u7adf\u91cf\u5c11\uff1b\u5176\u6b21\u5c31\u662fEPO\u548cTPO\u4e24\u8005\u7684\u5206\u5b50\u5927\u5c0f\u4e86\uff0cEPO\u7684\u5206\u5b50\u91cf\u662f18kD\uff0cTPO\u662f94kD<\/strong>\uff0c\u6240\u4ee5EPO\u80fd\u7b80\u5355\u5730\u901a\u8fc7\u80be\u810f\u8fc7\u6ee4\uff0c\u800cTPO\u5374\u4e0d\u884c[13]\uff1b\u6700\u540e\uff0c\u518d\u6765\u8bf4\u4e00\u8bf4\u4e24\u8005\u7684\u6d53\u5ea6\uff0c\u6b63\u5e38\u60c5\u51b5\u4e0bTPO\u7684\u6d53\u5ea6\u662fEPO\u6d53\u5ea6\u7684\u5343\u5206\u4e4b\u4e00<\/strong>[14,15]\uff0c\u5c31\u7b97\u524d\u9762\u4e24\u70b9\u90fd\u884c\u5f97\u901a\uff0c\u90a3\u4ece\u7b49\u91cf\u7684\u5c3f\u6db2\u91cc\u63d0\u53d6\u51faTPO\u6765\u4e5f\u662f\u96be\u4e0a\u52a0\u96be\u7684\u4e8b\u5440\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4ece\u5c3f\u6db2\u91cc\u63d0\u7eafTPO\u7684\u65b9\u6cd5\u5931\u8d25\u4e86\uff0c\u90a3\u8fd8\u6709\u4ec0\u4e48\u5176\u4ed6\u529e\u6cd5\u5417\uff1f\u79d1\u5b66\u5bb6\u4eec\u4e5f\u662f\u4e00\u7b79\u83ab\u5c55\u3002\u63d0\u7eafTPO\u7684\u5de5\u4f5c\u50cf\u662f\u88ab\u4eba\u70b9\u4e86\u7a74\u4e00\u6837\uff0c\u518d\u4e5f\u6ca1\u4e86\u4ec0\u4e48\u52a8\u9759\u3002<\/span><\/p>\n


<\/span><\/p>\n

30\u5e74\u540e\uff0c\u76f4\u52301992\u5e74\uff0c\u79d1\u5b66\u5bb6\u5728\u4e00\u53ea\u60a3\u6709\u9aa8\u9ad3\u589e\u751f\u6027\u767d\u8840\u75c5\u7684\u5c0f\u9f20\u8eab\u4e0a\u53d1\u73b0\u4e86\u539f\u764c\u57fa\u56e0c-mpl\u540e\uff0cTPO\u7684\u7814\u7a76\u624d\u53d6\u5f97\u4e86\u5de8\u5927\u7684\u8fdb\u5c55\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u6709\u65f6\u5019\u79d1\u5b66\u8fd8\u633a\u5947\u5999\u7684\uff0c\u770b\u4f3c\u4e00\u4e2a\u4e0d\u76f8\u5173\u7684\u53d1\u73b0\u5374\u80fd\u5bf9\u53e6\u4e00\u4e2a\u9886\u57df\u4ea7\u751f\u50ac\u5316\u4f5c\u7528\u3002\u800c\u8fd9\u4e00\u5207\u7684\u4e00\u5207\u90fd\u8981\u611f\u8c22\u4e00\u53ea\u8001\u9f20\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"<\/span><\/p>\n


<\/span><\/p>\n

1992\u5e74\uff0c\u7814\u7a76\u4eba\u5458\u5728\u4e00\u53ea\u611f\u67d3\u4e86\u9aa8\u9ad3\u589e\u751f\u6027\u767d\u8840\u75c5\u75c5\u6bd2\uff08MPLV\uff09<\/strong>\u7684\u5c0f\u9f20\u8eab\u4e0a\u53d1\u73b0\u4e86\u4e00\u4e2a\u539f\u764c\u57fa\u56e0c-mpl[16,17]\u3002\u539f\u764c\u57fa\u56e0\u591a\u4e86\u53bb\u4e86\uff0c\u8fd9\u4e2a\u539f\u764c\u57fa\u56e0\u6709\u4ec0\u4e48\u7279\u522b\u4e4b\u5904\u5462\uff1f<\/span><\/p>\n


<\/span><\/p>\n

\u539f\u6765\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u8fd9\u4e2a\u539f\u764c\u57fa\u56e0\u7f16\u7801\u7684c-Mpl\u86cb\u767d\u5177\u6709\u4e0eTPO\u53d7\u4f53\u76f8\u540c\u7684\u6240\u6709\u7279\u5f81<\/strong>[18]\u3002\u65e2\u7136\u4e00\u628a\u9501\u53ea\u80fd\u914d\u4e00\u628a\u94a5\u5319\uff0c\u90a3\u627e\u5230c- Mpl\u7684\u914d\u4f53\u662f\u4e0d\u662f\u5c31\u80fd\u627e\u5230\u76f8\u5e94\u7684TPO\u4e86\uff1f<\/span><\/p>\n


<\/span><\/p>\n

\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"<\/span><\/p>\n

\u25b2 \u63d2\u753b\uff1a\u5947\u70b9\u63d2\u753b\u5e08\u738b\u723d<\/span><\/p>\n


<\/span><\/p>\n

\u4e8e\u662f\u987a\u7740\u8fd9\u4e2a\u601d\u8def\uff0c\u7814\u7a76\u4eba\u5458\u731c\u60f3c-Mpl\u914d\u4f53\u5e94\u8be5\u5c31\u662fTPO\u4e86\u3002\u8fd9\u4e0b\u597d\u8bf4\u4e86\uff0c\u90a3\u5c31\u76f4\u63a5\u627ec-Mpl\u914d\u4f53\u5457\u3002\u77e5\u9053\u4e86c-mpl\u57fa\u56e0\uff0c\u60f3\u8981\u627e\u5230c-Mpl\u914d\u4f53\u8fd8\u4e0d\u662f\u987a\u85e4\u6478\u74dc\u7684\u4e8b\u561b\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u7814\u7a76\u4eba\u5458\u9996\u5148\u901a\u8fc7\u57fa\u56e0\u514b\u9686\u6280\u672f\u514b\u9686\u51fa\u4e86\u5927\u91cf\u7684c-mpl\u57fa\u56e0\uff0c\u7136\u540e\u8ba9\u5176\u8868\u8fbe\u51fac-Mpl\u86cb\u767d\uff0c\u8fd9\u6837\u4e00\u6765\u4e0d\u5c31\u80fd\u627e\u5230\u5927\u91cf\u7684c-Mpl\u914d\u4f53\u4e86\u561b\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u770b\u4f3c\u7b80\u5355\u7684\u4e8b\u60c5\uff0c\u5f53\u771f\u505a\u8d77\u6765\u5374\u6ca1\u90a3\u4e48\u5bb9\u6613\u3002\u4ece\u5f00\u59cb\u514b\u9686c-mpl\u57fa\u56e0\u5230\u6700\u540e\u627e\u5230c-Mpl\u914d\u4f53\uff0c\u79d1\u5b66\u5bb6\u4eec\u7528\u4e86\u6574\u6574\u4e24\u5e74\u7684\u65f6\u95f4\u3002<\/span><\/p>\n


<\/span><\/p>\n

c-Mpl\u914d\u4f53\u662f\u627e\u5230\u4e86\uff0c\u90a3\u5b83\u5230\u5e95\u662f\u4e0d\u662fTPO\u5462\uff1f\u79d1\u5b66\u5bb6\u53c8\u8fdb\u884c\u4e86\u4e00\u9879\u8bd5\u9a8c\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u7814\u7a76\u4eba\u5458\u5c06c-Mpl\u914d\u4f53\u52a0\u5165\u5230\u5254\u9664\u4e86\u5de8\u6838\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\uff08MEG-CSF\uff09\uff08\u4e00\u79cd\u53ef\u4ee5\u8c03\u8282\u5de8\u6838\u7cfb\u7956\u7ec6\u80de\u7684\u751f\u957f\u7684\u56e0\u5b50\uff09\u7684\u8840\u5c0f\u677f\u51cf\u5c11\u7684\u8840\u6d46\u4e2d\uff0c\u7ed3\u679c\u53d1\u73b0\u8840\u5c0f\u677f\u7684\u6570\u91cf\u786e\u5b9e\u5347\u9ad8\u4e86\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u6ca1\u9519\uff0cc-Mpl\u914d\u4f53\u5c31\u662fTPO\u4e86<\/strong>\uff01<\/span><\/p>\n


<\/span><\/p>\n

TPO\u63d0\u53d6\u7684\u6210\u529f\uff0c\u5438\u5f15\u4e86\u8bb8\u591a\u5b9e\u9a8c\u5ba4\u524d\u6765\u7814\u7a76\u5e76\u5206\u79bb\u3001\u63d0\u7eafTPO\uff0c\u4f46\u5927\u591a\u6570\u5b9e\u9a8c\u5ba4\u90fd\u5931\u8d25\u4e86\uff0c\u6700\u7ec8\u53ea\u67095\u5bb6\u72ec\u7acb\u7684\u5b9e\u9a8c\u5ba4\u53d6\u5f97\u4e86\u6210\u529f[19-21]\uff0c\u5176\u4e2d\u6709\u7f8e\u56fd\u7684\u5b89\u8fdb\u516c\u53f8<\/strong>\uff08\u5168\u7403\u6700\u5927\u751f\u7269\u5236\u836f\u4f01\u4e1a\u4e4b\u4e00\uff09\u548c\u57fa\u56e0\u6cf0\u514b\u516c\u53f8<\/strong>\uff08\u751f\u7269\u533b\u836f\u9886\u57df\u7684\u5f00\u521b\u8005\uff09\u3002<\/span><\/p>\n


<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

rhTPO\u73b0\u950b\u8292<\/span><\/p>\n<\/section>\n<\/section>\n


<\/p>\n<\/section>\n

\n
\n
\n

\u4ece\u8840\u6d46\u4e2d\u5206\u79bb\u63d0\u7eaf\u51faTPO\u786e\u5b9e\u662f\u4e00\u4ef6\u53ef\u559c\u53ef\u8d3a\u7684\u4e8b\uff0c\u4f46\u6bd5\u7adf\u8840\u6d46\u4e2d\u7684TPO\u975e\u5e38\u5c11\uff0c\u60f3\u8981\u5927\u91cf\u63d0\u7eafTPO\u8fd8\u771f\u662f\u4e00\u4ef6\u9ebb\u70e6\u4e8b\uff0c\u600e\u4e48\u529e\u5462\uff1f\u57fa\u56e0\u91cd\u7ec4\u5427\u3002<\/span><\/p>\n


<\/span><\/p>\n

1994\u5e74\uff0c\u79d1\u5b66\u5bb6\u5f00\u59cb\u5bf9\u4e24\u79cd\u91cd\u7ec4\u8840\u5c0f\u677f\u751f\u6210\u7d20\u8fdb\u884c\u4e34\u5e8a\u7814\u7a76\uff0c\u4e00\u4e2a\u662f\u7531\u5b89\u8fdb\u9886\u5bfc\u7684\u805a\u4e59\u4e8c\u9187\u5316\u4eba\u5de8\u6838\u7ec6\u80de\u751f\u957f\u53d1\u80b2\u56e0\u5b50<\/strong>(PEG-rhMGDF)\uff0c\u4e00\u4e2a\u662f\u7531\u56fd\u5185\u79d1\u7814\u4eba\u5458\u9886\u5bfc\u7684\u91cd\u7ec4\u4eba\u8840\u5c0f\u677f\u751f\u6210\u7d20<\/strong>(rhTPO)[22]\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u867d\u7136\u4e24\u79cd\u56e0\u5b50\u5728\u52a8\u7269\u6a21\u578b\u548c\u4eba\u7c7b\u8bd5\u9a8c\u4e2d\u90fd\u8868\u73b0\u51fa\u4e86\u5bf9\u8840\u5c0f\u677f\u7684\u751f\u957f\u6709\u5f3a\u6709\u529b\u7684\u523a\u6fc0\u4f5c\u7528\uff0c\u4f46\u53ef\u60dc\u7684\u662f\uff0c\u5b89\u8fdb\u7684PEG-rhMGDF\u5728\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u65f6\u51fa\u73b0\u4e86\u4e00\u4e9b\u95ee\u9898\u800c\u6700\u7ec8\u505c\u6b62\u4e86\u8bd5\u9a8c\u3002\u8fd9\u662f\u600e\u4e48\u56de\u4e8b\u5462\uff1f<\/span><\/p>\n


<\/span><\/p>\n

\u539f\u6765\u5b89\u8fdb\u516c\u53f8\u4e3a\u4e86\u52a0\u5feb\u7814\u53d1\u901f\u5ea6\u8d70\u4e86\u6377\u5f84\uff0c\u628a\u539f\u672c\u5168\u957f332\u4e2a\u6c28\u57fa\u9178\u7684\u4eba\u7c7bTPO\u622a\u65ad\uff0c\u53ea\u4fdd\u7559\u4e86\u524d\u9762\u7684153\u4e2a\u6c28\u57fa\u9178\uff0c\u7136\u540e\u5c06PEG\u5305\u57cb\uff0c\u53d8\u6210\u4e86\u53e6\u4e00\u4e2a\u622a\u65ad\u7684\u3001\u975e\u7cd6\u57fa\u5316\u7684TPO<\/strong>[23]\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"<\/span><\/p>\n

\u25b2 \u4e24\u79cd\u91cd\u7ec4\u8840\u5c0f\u677f\u751f\u6210\u7d20\u7684\u7ed3\u6784<\/span><\/p>\n


<\/span><\/p>\n

\u5374\u4e0d\u6599\u8fd9\u79cd\u8bd5\u56fe\u62a2\u5360\u5148\u673a\u7684\u884c\u4e3a\u7ed3\u679c\u5374\u9002\u5f97\u5176\u53cd\uff0c\u4ee5\u81f4\u4e8e\u5728\u4e4b\u540e\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u4e0d\u5c11\u60a3\u8005\u4ea7\u751f\u4e86\u5927\u91cf\u7684\u4e2d\u548c\u6027\u6297\u4f53<\/strong>[24,25]\uff0c\u6700\u7ec8\u5bfc\u81f4\u8bd5\u9a8c\u505c\u6b62\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5b89\u8fdb\u7684PEG-rhMGDF\u5012\u4e0b\u4e86\uff0c\u90a3\u56fd\u5185\u4f01\u4e1a\u7684\u91cd\u7ec4\u4eba\u8840\u5c0f\u677f\u751f\u6210\u7d20(rhTPO)\u5462\uff1f<\/span><\/p>\n


<\/span><\/p>\n

\u4e0e\u5b89\u8fdb\u7684PEG-rhMGDF\u76f8\u6bd4\uff0crhTPO\u5219\u662f\u5728\u4e2d\u56fd\u4ed3\u9f20\u5375\u5de2\u7ec6\u80de\u4e2d\u8868\u8fbe\u7684\u5168\u957f\u91cd\u7ec4\u3001\u9ad8\u5ea6\u7cd6\u57fa\u5316\u7684\u4ebaTPO<\/strong>[22]\u3002\u6240\u4ee5\u4ece\u7ed3\u6784\u4e0a\u8bb2\uff0crhTPO\u6bd4\u5b89\u8fdbPEG-rhMGDF\u5df2\u7ecf\u7565\u80dc\u4e00\u7b79\u4e86\uff0c\u90a3\u6548\u679c\u600e\u4e48\u6837\u5462\uff1f\u662f\u9aa1\u5b50\u662f\u9a6c\u8fd8\u662f\u5f97\u62ff\u51fa\u6765\u905b\u905b\u624d\u77e5\u9053\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u7814\u7a76\u4eba\u5458\u5728\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u7684\u60a3\u8005\u4e2d\u8fdb\u884c\u4e86\u4e00\u9879\u8bd5\u9a8c\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u5728\u7ed9\u4e88\u5355\u5242\u91cfrhTPO\u540e\uff0c\u60a3\u8005\u7684\u8840\u5c0f\u677f\u6570\u91cf\u5728\u7b2c4-5\u5929\u65f6\u5c31\u51fa\u73b0\u4e86\u5347\u9ad8\u8d8b\u52bf\uff0c\u5e76\u5728\u7b2c10-14\u5929\u65f6\uff0c\u8840\u5c0f\u677f\u6570\u91cf\u8fbe\u5230\u4e86\u4e2d\u4f4d\u5cf0\u503c<\/strong>[26]\uff0c\u5e76\u4e14\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\u6ca1\u6709\u51fa\u73b0\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u770b\u6765rhTPO\u7684\u8bd5\u9a8c\u7ed3\u679c\u8fd8\u662f\u76f8\u5f53\u53ef\u89c2\u7684\uff01<\/span><\/p>\n


<\/span><\/p>\n

2005\u5e745\u6708\uff0c\u8fd9\u9879\u7531\u4e09\u751f\u5236\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u9996\u521b\u65b0\u836f\uff08First in class\uff09rhTPO\u2014\u2014\u7279\u6bd4\u6fb3\uff0c\u987a\u5229\u83b7\u5f97\u65b0\u836f\u8bc1\u4e66\uff0c\u6b63\u5f0f\u4e0a\u5e02\u3002<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\u7136\u800c\u8fd9\u4e2a\u4ee4\u56fd\u4eba\u9a84\u50b2\u7684rhTPO\u5728\u5f53\u5e74\u7814\u53d1\u65f6\uff0c\u53ef\u662f\u9047\u5230\u4e86\u4e0d\u5c11\u96be\u9898\u3002\u9996\u5148\u5f53\u65f6\u56fd\u5185\u7684\u57fa\u56e0\u91cd\u7ec4\u6280\u672f\u5e76\u4e0d\u5b8c\u5584\uff0c\u56fd\u5185\u7684\u79d1\u5b66\u5bb6\u9700\u8981\u5728\u5df2\u77e5\u7684\u5f88\u5c11\u7684\u4fe1\u606f\u91cf\u4e0a\u60f3\u529e\u6cd5\u628a\u4eba\u4f53\u5185\u7f16\u7801TPO\u7684cDNA\u57fa\u56e0\u7ed9\u201c\u9493\u201d\u51fa\u6765\uff0c\u5176\u6b21\u5c31\u662f\u5728\u7cd6\u57fa\u5316\u8d85\u8fc7\u4e8670%\u7684rhTPO\u4e2d\u5b8c\u6210\u7eaf\u5316\u5de5\u4f5c\uff0c\u6700\u540e\u8fd8\u6709\u8868\u8fbe\u7ec6\u80de\u7684\u7b5b\u9009\u7b49\u7b49\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8fd9\u5176\u4e2d\u7684\u6bcf\u4e00\u4e2a\u73af\u8282\u5bf9\u4e8e\u60f3\u8981\u7814\u53d1\u4e00\u4e2a\u5168\u65b0\u751f\u7269\u5236\u5242\u7684\u4f01\u4e1a\u6765\u8bf4\u90fd\u662f\u6781\u5177\u6311\u6218\u7684\uff0c\u7136\u800c\u8fd9\u5e2e\u53ef\u7231\u7684\u56fd\u5185\u79d1\u5b66\u5bb6\u4eec\u5374\u8fce\u96be\u800c\u4e0a\uff0c\u6ca1\u6709\u4e00\u4e1d\u677e\u61c8\uff0c\u79c9\u627f\u7740\u4e0d\u8ba4\u8f93\u7684\u79d1\u7814\u7cbe\u795e\uff0c\u6700\u7ec8\u653b\u514b\u4e86\u4e00\u4e2a\u4e2a\u96be\u5173\uff0c\u7814\u5236\u51fa\u4e86rhTPO\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"<\/span><\/p>\n


<\/span><\/p>\n

\u8bf4\u5230\u8fd9\u91cc\u662f\u4e0d\u662f\u5e94\u8be5\u7ed9\u4ed6\u4eec\u70b9\u4e2a\u8d5e\u5462\uff1f\u5f53\u7136\u4e86\uff0c\u4efb\u4f55\u79d1\u7814\u6210\u679c\u90fd\u662f\u503c\u5f97\u88ab\u5c0a\u656c\u7684\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4f5c\u4e3a\u4e2d\u56fd\u81ea\u4e3b\u7814\u53d1\u7684\u4e16\u754c\u4e0a\u7b2c\u4e00\u4e2a\u5b8c\u6210 rhTPO \u8bd5\u9a8c\u7684\u57fa\u56e0\u5de5\u7a0b\u836f\u7269\uff0c\u201c\u7279\u6bd4\u6fb3\u201d\u76ee\u524d\u5df2\u6210\u4e3a\u539f\u53d1\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7<\/span><\/strong>\uff08ITP\uff09<\/span>\uff08<\/span>\u4ee5\u5f80\u79f0\u4e3a\u7279\u53d1\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u6027\u7d2b\u765c<\/span>\uff09<\/span><\/span>\u548c\u80bf\u7624\u5316\u7597\u6240\u81f4\u7684\u8840\u5c0f\u677f\u51cf\u5c11\uff08CIT\uff09\u7684\u6cbb\u7597\u836f\u7269\u3002<\/strong><\/span><\/p>\n


<\/span><\/p>\n

2017 \u5e74\uff0c\u7279\u6bd4\u6fb3\u88ab\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u6b63\u5f0f\u7eb3\u5165\u4e59\u7c7b\u76ee\u5f55\u8303\u7574\uff0c\u7528\u4e8eCIT\u548cITP\u7684\u6cbb\u7597\u30022018\u5e74\uff0c\u7279\u6bd4\u6fb3\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u8fdb\u5165\u513f\u7ae5\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u7684\u2162\u671f\u4e34\u5e8a\u3002<\/span><\/p>\n


<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

rhTPO\u7684\u6f5c\u5728\u4e34\u5e8a\u5e94\u7528<\/span><\/p>\n<\/section>\n<\/section>\n


<\/p>\n<\/section>\n

\n
\n
\n

\u9664\u4e86\u4e0a\u9762\u8bb2\u7684\u9002\u5e94\u75c7\u4ee5\u5916\uff0crhTPO\u8fd8\u5728\u5176\u4ed6\u5f15\u8d77\u8840\u5c0f\u677f\u51cf\u5c11\u7684\u75be\u75c5\u4e2d\u5177\u6709\u6f5c\u5728\u7684\u4e34\u5e8a\u5e94\u7528\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u25c6 \u598a\u5a20\u5408\u5e76\u539f\u53d1\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff08\u598a\u5a20ITP\uff09<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\u7531\u4e8e\u5b55\u671f\u5185\u73af\u5883\u3001\u6fc0\u7d20\u4e0e\u8425\u517b\u6c34\u5e73\u7684\u53d8\u5316\uff0c\u5b55\u5988\u5988\u7684\u8840\u6db2\u901a\u5e38\u4e5f\u4f1a\u51fa\u73b0\u4e00\u4e9b\u53d8\u5316\uff0c\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u53ef\u4ee5\u8bf4\u662f\u5b55\u671f\u6700\u5e38\u89c1\u7684\u8840\u6db2\u5f02\u5e38\u75be\u75c5\u4e86\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"<\/p>\n

\u25b2 \u5de6\u8fb9\u662f\u6b63\u5e38\u60c5\u51b5\u4e0b\u8840\u5c0f\u677f\u7684\u6570\u91cf\uff0c\u53f3\u8fb9\u662f\u8840\u5c0f\u677f\u51cf\u5c11\u65f6\u8840\u5c0f\u677f\u7684\u6570\u91cf<\/span><\/p>\n


<\/p>\n

\u5982\u679c\u5b55\u5988\u5988\u7684\u8840\u5c0f\u677f\u8ba1\u6570<30\u00d7109\/L\uff0c\u5c31\u4f1a\u51fa\u73b0\u51fa\u8840\u75c7\u72b6\uff0c\u4e25\u91cd\u65f6\u8fd8\u6709\u53ef\u80fd\u53d1\u751f\u4ea7\u540e\u51fa\u8840\u3001\u80ce\u76d8\u65e9\u5265\u7684\u5371\u9669\u3002\u5728\u4e00\u9879\u6d89\u53ca31\u540d\u8840\u5c0f\u677f\u51cf\u5c11\u7684\u5b55\u5988\u5988\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u7ed9\u4e88\u4e86\u521d\u59cb\u5242\u91cf300U\/kg\u7684rhTPO\u6cbb\u7597\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u517114\u5929\u3002\u7ed3\u679c\u663e\u793a\u670974.2%\u7684\u60a3\u8005\u4ea7\u751f\u4e86\u4e0d\u540c\u7a0b\u5ea6\u7684\u8840\u5c0f\u677f\u56de\u5347[27]\u3002
<\/span><\/p>\n


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\u25c6 \u809d\u529f\u80fd\u8870\u7aed<\/span><\/strong><\/p>\n


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\u809d\u662f\u4ea7\u751fTPO\u7684\u4e3b\u8981\u90e8\u4f4d\uff0c\u6240\u4ee5\u809d\u529f\u80fd\u8870\u7aed\u7684\u60a3\u8005\u4e5f\u4f1a\u65f6\u5e38\u4f34\u6709\u8840\u5c0f\u677f\u51cf\u5c11\uff0c\u800c\u8fd9\u5927\u90e8\u5206\u539f\u56e0\u53ef\u80fd\u662f\u7531\u4e8e\u809d\u810f\u635f\u4f24\u540eTPO\u4ea7\u751f\u4e0d\u8db3\u9020\u6210\u7684[28]\uff0c\u6240\u4ee5rhTPO\u5728\u809d\u529f\u80fd\u8870\u7aed\u4e2d\u7684\u5e94\u7528\u4e5f\u662f\u5f88\u6709\u524d\u666f\u7684\u3002<\/span><\/p>\n


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\u25c6 \u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u75c7<\/span><\/strong><\/p>\n


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\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u4e5f\u662f\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u6700\u5e38\u51fa\u73b0\u7684\u75c7\u72b6\u4e4b\u4e00\uff0c\u867d\u7136\u8840\u5c0f\u677f\u8f93\u8840\u6cbb\u7597\u53ef\u4ee5\u6682\u65f6\u6709\u6548\u5730\u63a7\u5236\u4e25\u91cd\u7684\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff0c\u4f46\u8fd9\u4e5f\u5b58\u5728\u4e00\u5b9a\u7684\u98ce\u9669\u95ee\u9898\u3002\u4f8b\u5982\uff0c\u91cd\u590d\u514d\u75ab\u548c\u540c\u79cd\u5f02\u4f53\u514d\u75ab\u3001\u4f20\u67d3\u5a92\u4ecb\u7684\u4f20\u64ad\u548c\u8f93\u8840\u53cd\u5e94\u7b49\u7b49[29]\u3002\u56e0\u6b64\u91c7\u7528rhTPO\u6cbb\u7597\u6210\u4e3a\u4e86\u9aa8\u9ad3\u589e\u751f\u6027\u60a3\u8005\u7684\u4e00\u79cd\u53ef\u80fd\u3002<\/span><\/p>\n


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\u4ece\u767e\u5e74\u524d\u53d1\u73b0\u8840\u5c0f\u677f\u5230\u5982\u4ecarhTPO\u88ab\u7528\u4e8e\u4e34\u5e8a\uff0c\u6211\u4eec\u89c1\u8bc1\u4e86\u79d1\u7814\u80cc\u540e\u7684\u6545\u4e8b\uff0c\u4e5f\u88ab\u90a3\u4e9b\u53ef\u7231\u7684\u79d1\u5b66\u5bb6\u4eec\u6240\u611f\u52a8\u3002rhTPO\u7684\u6545\u4e8b\u5199\u5b8c\u4e86\uff0c\u4f46rhTPO\u7684\u4f20\u5947\u8fd8\u5c06\u4f1a\u7ee7\u7eed\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u7f16\u8f91\uff1aleon<\/span><\/p>\n


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\u63a8\u8350\u9605\u8bfb<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"<\/span><\/span><\/a>
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\u540e\u53f0\u56de\u590d<\/span><\/strong>\u201c\u7fa4\u201d<\/span><\/strong><\/span><\/p>\n

\u8fdb\u7fa4\u8ba8\u8bba\u533b\u836f\u884c\u4e1a\u65b0\u653f\u3001\u6fc0\u8fa9\u533b\u836f\u4ea7\u4e1a\u8d8b\u52bf!<\/span><\/strong><\/p>\n


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\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"<\/section>\n

\u5fae\u4fe1\u516c\u4f17\u53f7\u5373\u5c06\u5168\u65b0\u6539\u7248<\/span><\/p>\n

\u5982\u679c\u4e0d\u60f3\u5728\u4fe1\u606f\u6d41\u4e2d\u548c\u5065\u8bc6\u5c40\u201c\u8d70\u5931\u201d<\/span><\/p>\n<\/section>\n<\/section>\n

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\u661f\u6807<\/span>\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"\u8d76\u7d27\u6807\u8d77\u6765~\u9519\u8fc7\u63a8\u9001\u540e\u6094\u4e00\u5e74<\/span><\/strong><\/p>\n


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\"\u9a84\u50b2\uff01\u5386\u65f640\u5e74\uff0c\u8de8\u56fd\u5de8\u5934\u653e\u5f03\uff0c\u8fd9\u5bb6\u4e2d\u56fd\u836f\u4f01\u575a\u6301\u5230\u6700\u540e\"<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u535a\u96c5\u5929\u4e0b\u65d7\u4e0b\u4ea7\u54c1 \u300a\u8d22\u7ecf\u5929\u4e0b\u300b\u300a\u4eba\u7269\u300b\u300a\u535a\u5ba2\u5929\u4e0b\u300b \u6bcf\u65e5\u4eba\u7269\u3001AI\u8d22\u7ecf\u793e\u3001\u5e02\u754c\u3001\u5065\u8bc6\u5c40\u3001\u706b\u661f\u8bd5\u9a8c\u5ba4\u3001\u548b\u6574 \u7f16\u8005 […]<\/p>\n","protected":false},"author":1,"featured_media":57046,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/57045"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=57045"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/57045\/revisions"}],"predecessor-version":[{"id":57062,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/57045\/revisions\/57062"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/57046"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=57045"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=57045"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=57045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}