{"id":57412,"date":"2018-11-05T01:00:00","date_gmt":"2018-12-07T02:22:37","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/226f060a2b\/"},"modified":"2018-12-07T10:22:38","modified_gmt":"2018-12-07T02:22:38","slug":"226f060a2b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/57412\/","title":{"rendered":"\u7814\u7a76\u4eba\u5458\u5229\u7528\u6838\u9178\u81ea\u7ec4\u88c5\u7ed3\u6784\u5b9e\u73b0\u57fa\u56e0\u836f\u7269\u9012\u9001"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><span style=\"font-size: 15px;\">\u57fa\u56e0\u6cbb\u7597\u662f\u4e00\u7c7b\u5728\u75be\u75c5\u53d1\u751f\u7684\u6700\u6839\u672c\u5c42\u9762\u4e0a\u5b9e\u73b0\u76f8\u5173\u6cbb\u7597\u7684\u7814\u7a76\u7b56\u7565\u3002\u73b0\u5df2\u4e0a\u5e02\u7684\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u5927\u591a\u662f\u4ee5\u75c5\u6bd2\u4e3a\u8f7d\u4f53\u5b9e\u73b0\u57fa\u56e0\u9012\u9001\u7684\u3002\u75c5\u6bd2\u8f7d\u4f53\u7684\u5f15\u5165\u65e0\u7591\u4f1a\u5f15\u8d77\u4eba\u4eec\u5bf9\u8be5\u7c7b\u6cbb\u7597\u4f53\u7cfb\u7684\u751f\u7269\u5b89\u5168\u6027\u4ea7\u751f\u987e\u8651\u3002\u56e0\u6b64\uff0c\u53d1\u5c55\u751f\u7269\u76f8\u5bb9\u7684\u57fa\u56e0\u9012\u9001\u8f7d\u4f53\u5c31\u663e\u5f97\u8d8a\u6765\u8d8a\u91cd\u8981\uff0c\u5e76\u4e14\u6210\u4e3a\u5177\u6709\u6311\u6218\u6027\u7684\u524d\u6cbf\u8bfe\u9898\u4e4b\u4e00\u3002\u8fd1\u5e74\u6765\u53d1\u5c55\u8d77\u6765\u7684DNA\u6298\u7eb8\u7eb3\u7c73\u6280\u672f\u662f\u4e00\u79cd\u72ec\u7279\u7684\u81ea\u4e0b\u800c\u4e0a\u7684\u81ea\u7ec4\u88c5\u7eb3\u7c73\u6280\u672f\uff0c\u53ef\u88ab\u7528\u4e8e\u8bbe\u8ba1\u548c\u5236\u5907\u5177\u6709\u5404\u7c7b\u5c3a\u5bf8\u548c\u5f62\u8c8c\u53ef\u63a7\u7684\u81ea\u7ec4\u88c5\u7eb3\u7c73\u7ed3\u6784\u3002DNA\u7eb3\u7c73\u7ed3\u6784\u548c\u57fa\u56e0\u836f\u7269\u5177\u6709\u5316\u5b66\u7ec4\u6210\u4e0a\u7684\u4e00\u81f4\u6027\uff0c\u5728\u5177\u6709\u751f\u7269\u76f8\u5bb9\u6027\u7684\u57fa\u56e0\u9012\u9001\u8f7d\u4f53\u7684\u8bbe\u8ba1\u4e0a\u8868\u73b0\u51fa\u663e\u7740\u7684\u4f18\u52bf\u3002<\/span><\/p>\n<p><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p><span style=\"font-size: 15px;\">2012\u5e74\u4ee5\u6765\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u4e01\u5b9d\u5168\u8bfe\u9898\u7ec4\u4ee5\u81ea\u7ec4\u88c5\u7684\u591a\u529f\u80fd\u6838\u9178\u7eb3\u7c73\u7ed3\u6784\u4e3a\u57fa\u7840\uff0c\u6784\u5efa\u4e86\u4e00\u7cfb\u5217\u836f\u7269\u9012\u9001\u8f7d\u4f53\u3002\u6240\u9012\u9001\u7684\u836f\u7269\u7ec4\u5206\u6d89\u53ca\u5316\u7597\u5c0f\u5206\u5b50\u836f\u7269\uff08J. Am. Chem. Soc. 2012\uff0c 134\uff0c 13396\uff1b ACS Nano 2014\uff0c 8\uff0c 6633\uff09\u3001\u5149\u70ed\u6cbb\u7597\u7eb3\u7c73\u9897\u7c92\u836f\u7269\uff08Small 2015\uff0c 11\uff0c 5134\uff1b Adv. Mater. 2016\uff0c 28\uff0c 10000\uff09\u3001\u529f\u80fd\u6027\u86cb\u767d\u7c7b\u836f\u7269\uff08Nat. Biotechnol. 2018\uff0c 36\uff0c 258\uff09\uff0c\u4ee5\u53ca\u6838\u9178\u7c7b\u836f\u7269\uff08ACS&nbsp;appl. Mater. Interfaces 2017\uff0c 9\uff0c 20324\uff1b Nano Lett. 2018\uff0c 18\uff0c 3328\uff09\u3002\u8be5\u7c7b\u591a\u529f\u80fd\u6838\u9178\u7eb3\u7c73\u836f\u7269\u9012\u9001\u4f53\u7cfb\u8868\u73b0\u51fa\u975e\u5e38\u597d\u7684\u80bf\u7624\u9776\u5411\u6027\u548c\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u53ef\u4f5c\u4e3a\u5168\u65b0\u7684\u75be\u75c5\u8bca\u65ad\u548c\u6cbb\u7597\u5e73\u53f0\u3002\u5728\u6700\u8fd1\u53d1\u8868\u7684\u7814\u7a76\u5de5\u4f5c\u4e2d\uff0c\u4e01\u5b9d\u5168\u8bfe\u9898\u7ec4\u9996\u6b21\u5229\u7528DNA\u6298\u7eb8\u7ed3\u6784\u4e3a\u8f7d\u4f53\u9ad8\u6548\u4e14\u53ef\u63a7\u5730\u5b9e\u73b0\u4e86\u5316\u7597\u836f\u7269\u963f\u9709\u7d20\u548c\u7ebf\u6027\u5c0f\u53d1\u5361RNA\u8f6c\u5f55\u6a21\u677f\u7684\u5171\u9012\u9001\uff0c\u5b8c\u6210\u4e86\u5316\u7597\u548c\u57fa\u56e0\u6cbb\u7597\u7684\u8054\u5408\u7ed9\u836f\u3002\u8be5\u7814\u7a76\u6210\u679c\u4ee5A Tailored DNA Nanoplatform for Synergistic RNAi-\/Chemo- Therapy of Multidrug-Resistant Tumors \u4e3a\u9898\u88ab\u300a\u5fb7\u56fd\u5e94\u7528\u5316\u5b66\u300b\u6742\u5fd7\u5728\u7ebf\u53d1\u8868\uff08Angew. Chem. Int. Ed. 2018\uff0c DOI\uff1a 10.1002\/anie.201809452\uff09\u3002<\/span><\/p>\n<p><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p><span style=\"font-size: 15px;\">\u57fa\u56e0\u6cbb\u7597\u5728\u764c\u75c7\u6cbb\u7597\u9886\u57df\u7684\u7814\u7a76\u5df2\u7ecf\u88ab\u5e7f\u6cdb\u62a5\u9053\uff0c\u5927\u591a\u662f\u901a\u8fc7\u5404\u7c7b\u9633\u79bb\u5b50\u8102\u8d28\u4f53\u3001\u9ad8\u5206\u5b50\u805a\u5408\u7269\u548c\u65e0\u673a\u7eb3\u7c73\u9897\u7c92\u7b49\u4e3a\u8f7d\u4f53\u5b9e\u73b0\u57fa\u56e0\u9012\u9001\u3002\u591a\u529f\u80fdDNA\u7eb3\u7c73\u7ed3\u6784\u4f5c\u4e3a\u4e00\u79cd\u751f\u7269\u76f8\u5bb9\u7684\u7eb3\u7c73\u8f7d\u4f53\u53ef\u4ee5\u5f88\u597d\u5730\u5e94\u7528\u4e8e\u57fa\u56e0\u7c7b\u836f\u7269\u7684\u9012\u9001\u7814\u7a76\u3002\u4ee5\u9776\u5411\u4fee\u9970\u7684\u4e09\u89d2\u5f62DNA\u6298\u7eb8\u7ed3\u6784\u4e3a\u8f7d\u4f53\uff0c\u9996\u5148\u901a\u8fc7\u78b1\u57fa\u95f4\u5d4c\u63d2\u7684\u65b9\u5f0f\u5b9e\u73b0\u5316\u7597\u836f\u7269\u963f\u9709\u7d20\u7684\u9ad8\u6548\u8d1f\u8f7d\u3002\u968f\u540e\uff0c\u5229\u7528\u6838\u9178\u94fe\u95f4\u7684\u78b1\u57fa\u4e92\u8865\u914d\u5bf9\u7b56\u7565\u5b9a\u70b9\u8fde\u63a5\u4e0a\u9776\u5411\u591a\u836f\u8010\u836f\u76f8\u5173\u57fa\u56e0\uff08P\u7cd6\u86cb\u767d\u548c\u751f\u5b58\u7d20\uff09\u7684\u7ebf\u6027\u5c0f\u53d1\u5361RNA\u8f6c\u5f55\u6a21\u677f\u3002\u8be5\u7c7b\u5316\u7597\u836f\u7269\u548c\u57fa\u56e0\u836f\u7269\u5171\u8d1f\u8f7d\u7684DNA\u7eb3\u7c73\u7ed9\u836f\u4f53\u7cfb\u53ef\u901a\u8fc7\u4fee\u9970\u7684\u6838\u9178\u9002\u914d\u4f53\u5b9e\u73b0\u5bf9\u5177\u6709\u963f\u9709\u7d20\u8010\u836f\u6027\u7684\u4e73\u817a\u764c\u80bf\u7624\u7ec6\u80de\u9776\u5411\u9012\u9001\u3002\u901a\u8fc7\u80de\u5185pH\u54cd\u5e94\u548c\u8fd8\u539f\u6c1b\u56f4\u5b9e\u73b0\u963f\u9709\u7d20\u548c\u57fa\u56e0\u836f\u7269\u7684\u53ef\u63a7\u91ca\u653e\uff0c\u5229\u7528RNA\u5e72\u6270\u7684\u65b9\u6cd5\u5b9e\u73b0P\u7cd6\u86cb\u767d\u548c\u751f\u5b58\u7d20\u7684\u8868\u8fbe\u4e0b\u8c03\uff0c\u8fbe\u5230\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u3002\u5c0f\u9f20\u6d3b\u4f53\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u8be5\u7c7bDNA\u7eb3\u7c73\u7ed9\u836f\u4f53\u7cfb\u8868\u73b0\u51fa\u975e\u5e38\u597d\u7684\u80bf\u7624\u9776\u5411\u6027\u548c\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u80fd\u591f\u5bf9\u8010\u836f\u6027\u4e73\u817a\u764c\u80bf\u7624\u6a21\u578b\u4ea7\u751f\u663e\u7740\u7684\u6cbb\u7597\u6548\u679c\u3002\u8be5\u7814\u7a76\u57fa\u4e8e\u751f\u7269\u7cfb\u7edf\u7684\u5929\u7136\u6838\u9178\u7ed3\u6784\uff0c\u5b9e\u73b0\u4e86\u5316\u7597\u548c\u57fa\u56e0\u6cbb\u7597\u7684\u8054\u5408\u7ed9\u836f\uff0c\u4e3a\u6076\u6027\u80bf\u7624\u7b49\u75be\u75c5\u7684\u6cbb\u7597\u63d0\u4f9b\u65b0\u7684\u7814\u7a76\u7b56\u7565\u3002<\/span><\/p>\n<p><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p><span style=\"font-size: 15px;\">\u8bba\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\u662f\u56fd\u5bb6\u7eb3\u7c73\u4e2d\u5fc3\u52a9\u7406\u7814\u7a76\u5458\u5218\u5efa\u5175\uff0c\u901a\u8baf\u4f5c\u8005\u4e3a\u4e01\u5b9d\u5168\u3002\u8be5\u7814\u7a76\u5f97\u5230\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u59d4\u5458\u4f1a\u548c\u4e2d\u79d1\u9662\u524d\u6cbf\u79d1\u5b66\u91cd\u70b9\u7814\u7a76\u8ba1\u5212\u7b49\u7684\u652f\u6301\u3002<\/span><\/p>\n<p><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 14px;\">\uff08\u6765\u6e90\uff1a\u56fd\u5bb6\u7eb3\u7c73\u4e2d\u5fc3\uff09&nbsp;<\/span><\/p>\n<p style=\"text-align: center;\">\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u57fa\u56e0\u6cbb\u7597\u662f\u4e00\u7c7b\u5728\u75be\u75c5\u53d1\u751f\u7684\u6700\u6839\u672c\u5c42\u9762\u4e0a\u5b9e\u73b0\u76f8\u5173\u6cbb\u7597\u7684\u7814\u7a76\u7b56\u7565\u3002\u73b0\u5df2\u4e0a\u5e02\u7684\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u5927\u591a\u662f\u4ee5\u75c5\u6bd2\u4e3a\u8f7d\u4f53\u5b9e\u73b0\u57fa\u56e0 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":57413,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/57412"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=57412"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/57412\/revisions"}],"predecessor-version":[{"id":57414,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/57412\/revisions\/57414"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/57413"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=57412"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=57412"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=57412"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}