{"id":5784,"date":"2018-06-10T01:00:00","date_gmt":"2018-07-27T08:45:00","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e5%8e%9f%e8%be%85%e5%8c%85-6-7%e6%97%a5cde%e6%89%bf%e5%8a%9e1%e4%b8%aaapi\/"},"modified":"2018-07-27T16:45:01","modified_gmt":"2018-07-27T08:45:01","slug":"%e5%8e%9f%e8%be%85%e5%8c%85-6-7%e6%97%a5cde%e6%89%bf%e5%8a%9e1%e4%b8%aaapi","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/5784\/","title":{"rendered":"\u539f\u8f85\u5305 | 6.7\u65e5CDE\u627f\u529e1\u4e2aAPI"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;color: rgb(0, 0, 0);clear: both;background-color: transparent;\"><strong style=\"margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"><span style=\"box-sizing: border-box;font-size: 15px;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;word-wrap: break-word;\"><span style=\"box-sizing: border-box;font-size: 15px;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;word-wrap: break-word;\">\u7f6e\u9876\u201c<\/span><\/span><strong style=\"background-color: rgb(255, 255, 255);box-sizing: border-box;color: rgb(62, 62, 62);font-size: 16px;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;word-wrap: break-word;\"><span style=\"box-sizing: border-box;font-size: 15px;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;word-wrap: break-word;\"><span style=\"box-sizing: border-box;font-size: 15px;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;word-wrap: break-word;\"><span style=\"box-sizing: border-box;color: rgb(0, 82, 255);margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;word-wrap: break-word;\"><\/span><\/span><\/span><\/strong><span style=\"box-sizing: border-box;font-size: 15px;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;word-wrap: break-word;\"><span style=\"box-sizing: border-box;font-size: 15px;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;max-width: 100%;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;word-wrap: break-word;\">\u201d\uff0c\u83b7\u53d6\u6700\u65b0\u8d44\u8baf<\/span>\uff01<\/span><\/strong><\/p>\n<p style=\"text-align: center;color: rgb(0, 0, 0);clear: both;background-color: transparent;\"><span style=\"font-size: 12px;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\">\u672c\u6587\u7531\u516c\u4f17\u53f7\u539f\u521b\u6574\u7406\uff0c\u5982\u9700\u8f6c\u8f7d\u8bf7\u6ce8\u660e\u51fa\u5904\u3002<\/span><\/p>\n<p style=\"background-color: transparent;clear: both;color: rgb(0, 0, 0);\"><br style=\"margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"  \/><\/p>\n<p style=\"color: rgb(0, 0, 0);text-indent: 2em;clear: both;background-color: transparent;\"><span style=\"font-size: 15px;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"><strong style=\"margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"><strong style=\"margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\">2018\u5e746\u67087\u65e5\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u627f\u529e 1 \u4e2a\u5173\u8054\u5ba1\u8bc4\u5ba1\u6279\u7684\u539f\u6599\u836f<\/strong><\/strong>\uff1a<span style=\"background-color: transparent;color: rgb(0, 0, 0);display: inline;float: none;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\" sans=\"sans\" helvetica=\"helvetica\" px=\"px\" none=\"none\" normal=\"normal\" yahei=\"yahei\" gb=\"gb\" neue=\"neue\" left=\"left\">\u8fde\u4e91\u6e2f\u6da6\u7eb5\u5236\u836f\u6709\u9650\u516c\u53f8<span style=\"background-color: transparent;color: rgb(0, 0, 0);display: inline;float: none;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\" sans=\"sans\" helvetica=\"helvetica\" px=\"px\" none=\"none\" normal=\"normal\" yahei=\"yahei\" gb=\"gb\" neue=\"neue\" left=\"left\"><span style=\"background-color: transparent;color: rgb(0, 0, 0);display: inline;float: none;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\" sans=\"sans\" helvetica=\"helvetica\" px=\"px\" none=\"none\" normal=\"normal\" yahei=\"yahei\" gb=\"gb\" neue=\"neue\" left=\"left\">\uff08<span style=\"background-color: transparent;color: rgb(0, 0, 0);display: inline;float: none;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\" sans=\"sans\" helvetica=\"helvetica\" px=\"px\" none=\"none\" normal=\"normal\" yahei=\"yahei\" gb=\"gb\" neue=\"neue\" left=\"left\">\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c<\/span>\uff09\u3002<\/span><\/span><\/span><\/span><\/p>\n<p style=\"background-color: transparent;clear: both;color: rgb(0, 0, 0);\"><strong style=\"margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"><\/strong><\/p>\n<p><img style=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1532681101.png\" alt=\"\u539f\u8f85\u5305 | 6.7\u65e5CDE\u627f\u529e1\u4e2aAPI\" title=\"\u539f\u8f85\u5305 | 6.7\u65e5CDE\u627f\u529e1\u4e2aAPI\"  \/><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 15px;\">Imatinib mesylate is a white to off-white to brownish or yellowish tinged crystalline powder.&nbsp; Its molecular formula is C<\/span><span style=\"font-size: 12px;\">29<\/span><span style=\"font-size: 15px;\">H<\/span><span style=\"font-size: 12px;\">31<\/span><span style=\"font-size: 15px;\">N<\/span><span style=\"font-size: 12px;\">7<\/span><span style=\"font-size: 15px;\">O \u00b7 CH<\/span><span style=\"font-size: 12px;\">4<\/span><span style=\"font-size: 15px;\">SO<\/span><span style=\"font-size: 12px;\">3<\/span><span style=\"font-size: 15px;\"> and its relative molecular mass is 589.7.&nbsp; Imatinib mesylate is very soluble in water and soluble in aqueous buffers \u2264 pH 5.5 but is very slightly soluble to insoluble in neutral\/alkaline aqueous buffers. In non-aqueous solvents, the drug substance is freely soluble to very slightly soluble in dimethyl sulfoxide, methanol and ethanol, but is insoluble in&nbsp; n-octanol, acetone and&nbsp; acetonitrile.<\/span><\/p>\n<p style=\"text-indent: 2em;\"><br  \/><\/p>\n<p style=\"text-align: center;color: rgb(0, 0, 0);clear: both;background-color: transparent;\"><span style=\"font-size: 15px;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"><span style=\"color: rgb(123, 12, 0);font-size: 12px;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"><span style=\"color: rgb(123, 12, 0);font-size: 12px;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\"><span style=\"background-color: transparent;color: rgb(123, 12, 0);display: inline;float: none;margin-bottom: 0px;margin-left: 0px;margin-right: 0px;margin-top: 0px;padding-bottom: 0px;padding-left: 0px;padding-right: 0px;padding-top: 0px;\" sans=\"sans\" helvetica=\"helvetica\" px=\"px\" none=\"none\" normal=\"normal\" yahei=\"yahei\" gb=\"gb\" neue=\"neue\" center=\"center\">\u672c\u6587\u5185\u5bb9\u7531\u516c\u4f17\u53f7\u539f\u521b\u7f16\u8f91\/\u6392\u7248\uff0c\u8bfb\u8005\u53ef\u7528\u4e8e\u4e2a\u4eba\u5b66\u4e60\u3001\u7814\u7a76\uff0c\u4ee5\u53ca\u5176\u4ed6\u975e\u5546\u4e1a\u6027\u6216\u975e\u76c8\u5229\u6027\u7528\u9014\uff0c\u4f46\u5c06\u672c\u6587\u4efb\u4f55\u5185\u5bb9\u7528\u4e8e\u4efb\u610f\u7528\u9014\u65f6\uff0c\u987b\u5f81\u5f97\u516c\u4f17\u53f7\u53ca\u76f8\u5173\u6743\u5229\u4eba\u7684\u6388\u6743\u8bb8\u53ef\u3002\u6b22\u8fce\u4e2a\u4eba\u8bfb\u8005\u5206\u4eab\/\u4f20\u64ad\u76f8\u5173\u8d44\u8baf\uff0c\u5982\u679c\u559c\u6b22\u6211\u4eec\u5e73\u53f0\u7684\u5185\u5bb9\uff0c\u8bf7\u7f6e\u9876\u516c\u4f17\u53f7\uff0c\u5e76\u4e3a\u6211\u4eec\u70b9\u8d5e\u3002<\/span><\/span><\/span><\/span><\/p>\n<p style=\"margin: 0px;padding: 0px;text-align: left;color: rgb(0, 0, 0);text-transform: none;text-indent: 0px;letter-spacing: normal;font-size: 16px;font-style: normal;font-variant: normal;font-weight: 400;text-decoration: none;word-spacing: 0px;white-space: normal;orphans: 2;-webkit-text-stroke-width: 0px;background-color: transparent;\"><br  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                                               <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7f6e\u9876\u201c\u201d\uff0c\u83b7\u53d6\u6700\u65b0\u8d44\u8baf\uff01 \u672c\u6587\u7531\u516c\u4f17\u53f7\u539f\u521b\u6574\u7406\uff0c\u5982\u9700\u8f6c\u8f7d\u8bf7\u6ce8\u660e\u51fa\u5904\u3002 2018\u5e746\u67087\u65e5\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u627f\u529e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5785,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/5784"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=5784"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/5784\/revisions"}],"predecessor-version":[{"id":5787,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/5784\/revisions\/5787"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/5785"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=5784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=5784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=5784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}