{"id":57855,"date":"2018-11-15T01:00:00","date_gmt":"2018-12-07T02:27:55","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/5c0e6b11a9\/"},"modified":"2018-12-07T10:27:58","modified_gmt":"2018-12-07T02:27:58","slug":"5c0e6b11a9","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/57855\/","title":{"rendered":"\u672a\u67655\u5e74\u6700\u7545\u9500\u7684\u80bf\u7624\u836f\u7269TOP10\u9884\u6d4b\u53ca\u8d8b\u52bf\u8d70\u5411"},"content":{"rendered":"
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\u80bf\u7624\uff0c\u4f9d\u9760\u4e0d\u540c\u9002\u5e94\u75c7\u8fe5\u5f02\u7684\u53d1\u75c5\u673a\u5236\uff0c\u5e9e\u5927\u7684\u60a3\u8005\u4eba\u7fa4\uff0c\u6b7b\u4ea1\u7387\u4ec5\u6b21\u4e8e\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u6210\u4e3a\u4e86\u533b\u53d1\u7684\u65b0\u5ba0\uff0c\u5e02\u573a\u7684\u98ce\u53e3\uff0c\u5173\u6ce8\u7684\u7126\u70b9\u3002\u80bf\u7624\u5e02\u573a\u5e74\u5e73\u574712.2%\u7684\u589e\u957f\u7387\uff0c\u8fdc\u9ad8\u4e8e\u5904\u65b9\u836f6%\u7684\u589e\u957f\uff0c\u6210\u4e3a\u4e86\u5e02\u573a\u6700\u5927\u7684\u63a8\u52a8\u529b\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

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2001\u5e74\u4f0a\u9a6c\u66ff\u5c3c\u95ee\u4e16\u540e\uff0c\u5f00\u542f\u4e86\u80bf\u7624\u9776\u5411\u65f6\u4ee3\u7684\u6d6a\u6f6e\uff0c2011\u5e74\u4e4b\u540eCTLA-4\u5355\u6297\u3001PD-1\u6291\u5236\u5242\u3001CAR-T\u76f8\u7ee7\u4e0a\u5e02\uff0c\u80bf\u7624\u514d\u75ab\u65f6\u4ee3\u6eda\u6eda\u800c\u6765\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u80bf\u7624\u7684TOP10\u738b\u8005\u4e4b\u4f4d\uff0c\u72b9\u5982\u534e\u5c71\u8bba\u5251\u7684\u5929\u4e0b\u4e94\u7edd\uff0c\u7535\u5f71\u5c4a\u7684\u5965\u65af\u5361\u5c0f\u91d1\u4eba\uff0c\u5411\u6765\u5145\u6ee1\u4e86\u5200\u5149\u5251\u5f71\uff0c\u6697\u6f6e\u6d8c\u52a8\u3002<\/span><\/p>\n

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\u66fe\u7ecf\u699c\u4e0a\u8d6b\u8d6b\u6709\u540d\u7684\u4f0a\u9a6c\u66ff\u5c3c\u3001\u66f2\u59a5\u73e0\u5355\u6297\u3001\u8d1d\u4f10\u73e0\u5355\u6297\u3001\u5229\u59a5\u6614\u5355\u6297\u548c\u975e\u683c\u53f8\u4ead\u5728\u65f6\u95f4\u9762\u524d\u4e5f\u5f00\u59cb\u670d\u8001\uff0c\u611f\u53f9\u5915\u9633\u65e0\u9650\u597d\uff0c\u8bd5\u95ee\u4e13\u5229\u9976\u8fc7\u8c01\uff01\u672a\u6765\u53c8\u4f1a\u54ea\u4e9b\u836f\u7269\u80fd\u591f\u8131\u9896\u800c\u51fa\uff0c\u6210\u4e3a\u4e86\u80bf\u7624\u836f\u7269\u4e2d\u7684\u7fd8\u695a\u4e86\uff0c\u54ea\u4e9b\u80bf\u7624\u9002\u5e94\u75c7\u53c8\u5c06\u6210\u4e3a\u5175\u5bb6\u5fc5\u4e89\u4e4b\u5730\u4e86\uff1f<\/span><\/p>\n

 <\/span><\/p>\n

\u672c\u6392\u540d\u6309\u7167\u7f8e\u56fdEvaluatePharma\u516c\u53f8\u7684\u6392\u540d\u4e3a\u51c6\uff0c\u53c2\u716717\u5e74\u836f\u4f01\u7684\u516c\u53f8\u5e74\u62a5\uff0c\u52a0\u5165\u4e86\u4e2a\u4eba\u5bf9\u4e8e\u7814\u53d1\u8d8b\u52bf\u548c\u5e02\u573a\u8d70\u5411\u7684\u5206\u6790\uff0c\u6392\u540d\u5206\u5148\u540e\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\"\u672a\u67655\u5e74\u6700\u7545\u9500\u7684\u80bf\u7624\u836f\u7269TOP10\u9884\u6d4b\u53ca\u8d8b\u52bf\u8d70\u5411\"<\/p>\n


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 <\/span>Keytruda<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u80bf\u7624\u8981\u60f3\u53d1\u5c55\u6210\u6076\u6027\uff0c\u9996\u5148\u8981\u5177\u5907\u4e24\u4e2a\u6761\u4ef6\uff1a\u57fa\u56e0\u7a81\u53d8\uff0c\u89e3\u9664\u4eba\u4f53\u5bf9\u4e8e\u751f\u957f\u7684\u63a7\u5236\uff1b\u80bf\u7624\u9003\u9038\uff0c\u6446\u8131\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u7684\u6740\u4f24\u3002<\/span><\/p>\n

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\u4f5c\u4e3a\u66f4\u4e3a\u53e4\u8001\u7684\u751f\u7269\uff0c\u80bf\u7624\u4e5f\u6f14\u5316\u51fa\u5bf9\u5e94\u7684\u9003\u9038\u673a\u5236\uff1a\u964d\u4f4e\u80bf\u7624\u6297\u539f\u7684\u8868\u8fbe\u3001\u8868\u8fbe\u51fa\u80bf\u7624\u514d\u75ab\u5171\u6291\u5236\u7684\u86cb\u767d\u3002\u6839\u636e\u540e\u8005\u7814\u53d1\u7684\u6291\u5236\u5242\u53eb\u505a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u5305\u62ecCTLA-4\u5355\u6297\u3001PD-1\u5355\u6297\u3001PD-L1\u5355\u6297\u3001LAG-3\u5355\u6297\u7b49\u3002\u800cPD-1\u6291\u5236\u5242\u56e0\u4e3a\u5176\u4e34\u5e8a\u4e0a\u7684\u663e\u8457\u7597\u6548\u3001\u76f8\u5bf9\u8f83\u8f7b\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u6210\u4e3a\u4e86\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6700\u4e3a\u706b\u70ed\u7684\u9886\u57df\u3002<\/span><\/p>\n

 <\/span><\/p>\n

BMS\u516c\u53f8\u7684O\u836f\u4f5c\u4e3aPD-1\u6291\u5236\u5242\u7684\u201cfirst in class\u201d\uff0c\u4f9d\u9760\u4f17\u591a\u9002\u5e94\u75c7\u7684\u6279\u51c6\uff0c\u5728\u5e02\u573a\u9500\u552e\u65b9\u9762\u5904\u5904\u538b\u5236\u4e86\u9ed8\u6c99\u4e1c\u516c\u53f8\u7684K\u836f\u3002\u540c\u65f6BMS\u516c\u53f8\u53c8\u51ed\u501f\u4e13\u5229\u8bc9\u8bbc\u7684\u80dc\u5229\u83b7\u5f97\u9ed8\u6c99\u4e1c6.25\u4ebf\u7f8e\u91d1\u9996\u4ed8\u6b3e\uff0c\u53caK\u836f\u5e74\u9500\u552e\u989d2.5%-6.5%\u9500\u552e\u5206\u6210\uff0c\u8fd9\u4e5f\u5bfc\u81f4\u4e8615\u300116\u5e74K\u836f\u589e\u957f\u76f8\u6bd4\u4e8eO\u836f\u663e\u5f97\u76f8\u5f62\u89c1\u7ecc\u3002<\/span><\/p>\n

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2016\u5e7410\u670824\u65e5\u4f9d\u9760\u5927\u89c4\u6a21\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8ckeynote-024\u7684\u6210\u529f\uff0c\u62ff\u4e0b\u4e86PD-L1\u9633\u6027\uff08TPS\u226550%\uff09\uff0cEGFR-\u3001ALK-\uff0cNSCLC\u4e00\u7ebf\u7528\u836f\uff0c\u5f00\u59cb\u4e86\u81ea\u5df1\u7684\u9006\u88ad\u4e4b\u8def\u3002<\/span><\/p>\n

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2017\u5e7405\u670810\u65e5\uff0c\u8054\u5408\u5316\u7597\u836f\u7269\uff0c\u4e00\u7ebfNSCLC\u7528\u836f\u88abFDA\u83b7\u6279\uff0c\u8fdb\u4e00\u6b65\u5de9\u56fa\u4e86Keytruda\u7684\u9738\u4e3b\u5730\u4f4d\u3002<\/span><\/p>\n

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2018\u5e746\u6708\u4efd ASCO\uff0c\u9ed8\u6c99\u4e1c\u516c\u53f8\u53c8\u5ba3\u5e03\u4e86K\u836f\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8ckeynote-042\u7684\u6377\u62a5\uff0c\u5bf9\u4e8ePD-L1\u8868\u8fbe\u9633\u6027\uff08\u4e0d\u9700\u8981\u5f3a\u9633\u6027\uff0c\u53ea\u8981PD-L1\u8868\u8fbe\u8d85\u8fc71%\u5373\u53ef\uff09\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0cK\u836f\u6218\u80dc\u4e86\u6807\u51c6\u65b9\u6848\u5316\u7597\u3002\u57fa\u672c\u4e0aK\u836f\u6db5\u76d6\u4e8680%\u5de6\u53f3\u7684NSCLC\u60a3\u8005\uff0c\u8fdc\u8fdc\u7529\u5f00\u4e86O\u836f\u548c\u7f57\u6c0f\u7684T\u836f\u3002<\/span><\/p>\n

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2017\u5e745\u670813\u65e5\uff0cK\u836f\u53c8\u5728MSI-H\/dMMR\u4e9a\u578b\uff08\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u9ad8\uff09\u5b9e\u4f53\u7624\u83b7\u6279\u3002\u4ee5\u524d\u6297\u764c\u836f\u7684\u4e0a\u5e02\uff0c\u662f\u8981\u6309\u7167\u6765\u6e90\u6307\u660e\u80bf\u7624\u7c7b\u578b\uff0c\u6bd4\u5982\u7528\u4e8e\u6cbb\u7597\u201c\u80ba\u764c\u201d\u201c\u4e73\u817a\u764c\u201d\u201c\u809d\u764c\u201d\u7b49\u7b49\u3002\u800c\u8fd9\u4e00\u6b21\uff0cK\u836f\u7684\u83b7\u6279\u53d6\u51b3\u4e8e\u80bf\u7624\u7684\u57fa\u56e0\u7a81\u53d8\u7c7b\u578b\uff08\u4e5f\u53eb\u751f\u7269\u6807\u8bb0\u7269\uff09\uff0c\u6210\u4e3a\u4e86\u5927\u5bb6\u53e3\u4e2d\u7684\u201c\u5e7f\u8c31\u6297\u764c\u836f\u201d\uff0c\u5728\u80bf\u7624\u6cbb\u7597\u4e2d\u5177\u6709\u5212\u65f6\u4ee3\u7684\u610f\u4e49\u3002<\/span><\/p>\n

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\u80bf\u7624\u514d\u75ab\u5df2\u7ecf\u88ab\u8a89\u4e3a\u662f\u672a\u6765\u8054\u5408\u7528\u836f\u7684\u57fa\u77f3\uff0c\u800cKeytruday\u51ed\u501f\u8fd1\u4e24\u5e74\u7684\u8868\u73b0\uff0c\u5df2\u7ecf\u521d\u5177\u201cbest in class\u201d\u6c14\u8d28\uff0c\u66f4\u662f\u572818\u5e74Q2\u53cd\u8d85\u4e86O\u836f\uff0c\u6210\u4e3a\u4e86\u5f53\u4e4b\u65e0\u6127\u7684\u80bf\u7624NO.1\u3002<\/span><\/p>\n

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\u76ee\u524dK\u836f\u56ca\u62ec\u4e869\u4e2a\u80bf\u7624\u768412\u4e2a\u4ee5\u4e0a\u9002\u5e94\u75c7\uff0c\u5305\u62ec\u9ed1\u8272\u7d20\u7624\uff0c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u5934\u9888\u764c\uff0c\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u5c3f\u8def\u4e0a\u76ae\u764c\uff0c\u5bab\u9888\u764c\uff0c\u80c3\u764c\uff0cB\u7ec6\u80de\u6dcb\u5df4\u7624\u7b49\uff0c\u4e5f\u529b\u538bO\u836f\u6210\u4e3a\u4e86\u4e34\u5e8a\u4f7f\u7528\u6700\u4e3a\u5e7f\u6cdb\u7684PD-1\u6291\u5236\u5242\u3002<\/span><\/p>\n


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\"\u672a\u67655\u5e74\u6700\u7545\u9500\u7684\u80bf\u7624\u836f\u7269TOP10\u9884\u6d4b\u53ca\u8d8b\u52bf\u8d70\u5411\"<\/p>\n


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\u6765\u90a3\u5ea6\u80fa<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u6765\u90a3\u5ea6\u80fa\uff08\u6c99\u5229\u5ea6\u80fa\u7684\u6539\u9020\u836f\u7269\uff09\u662f\u7f8e\u56fd\u65b0\u57fa\u516c\u53f8\u5f00\u53d1\u7684\u6297\u80bf\u7624\u5316\u5b66\u836f\uff0c\u5177\u6709\u4e24\u4e2a\u4f5c\u7528\u673a\u7406\u3002<\/span>\u6700<\/span>\u5f00\u59cb\u662f\u4f5c\u4e3a\u5316\u7597\u836f\u7269\uff0c\u6740\u4f24\u80bf\u7624\u7ec6\u80de\uff0c\u540c\u65f6\u8fd8\u53ef\u4ee5\u4f5c\u4e3a\u514d\u75ab\u8c03\u8282\u5242\uff0c\u523a\u6fc0\u514d\u75ab\u7ec6\u80de\u7684\u6d3b\u5316\u3002<\/span><\/p>\n

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2005\u5e74\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81(MDS)\uff1b2006\u5e74\uff0cFDA\u6279\u51c6\u4e86\u4e00\u4e2a\u65b0\u9002\u5e94\u75c7\uff0c\u5373\u5408\u7528\u5730\u585e\u7c73\u677e\u6cbb\u7597\u5df2\u7ecf\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u7597\u6cd5\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\uff1b2013\u5e74\uff0cFDA\u6279\u51c6\u6765\u90a3\u5ea6\u80fa\u7528\u4e8e\u6cbb\u7597\u7ecf\u4e24\u79cd\u836f\u7269\u6cbb\u7597\u540e\u4ecd\u7136\u590d\u53d1\u6216\u8fdb\u5c55\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624(MCL)\u60a3\u8005\u7684\u8865\u5145\u65b0\u836f\u7533\u8bf7\u3002\u4e0d\u8fc7\u6765\u90a3\u5ea6\u80fa\u6700\u5927\u7684\u5e02\u573a\u6765\u6e90\u662f\u6765\u81ea\u4e8e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u3002MM\u662f\u4e00\u79cd\u65e0\u6cd5\u6cbb\u6108\u7684\u75be\u75c5\uff0c\u4e34\u5e8a\u6cbb\u7597\u7684\u4e3b\u8981\u76ee\u6807\u662f\u5c3d\u53ef\u80fd\u5ef6\u957f\u60a3\u8005\u751f\u5b58\u671f\u3002<\/span><\/p>\n

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\u5f97\u76ca\u4e8e\u5e02\u573a\u6269\u5bb9\u548c\u7528\u836f\u65f6\u7a0b\u7684\u589e\u52a0\uff08\u5df2\u664b\u5347\u4e3aMM\u4e00\u7ebf\u7528\u836f\uff09\uff0c\u6765\u90a3\u5ea6\u80fa2017\u5e74\u589e\u957f17%\uff0c\u9500\u552e\u989d\u8fbe\u523081.87\u4ebf\u7f8e\u5143\u3002\u4e0d\u8fc7\uff0c\u6700\u5927\u7ade\u4e89\u5bf9\u624b\u5f3a\u751f15\u5e74\u63a8\u51fa\u7684CD38\u5355\u6297\u7ed9\u6765\u90a3\u5ea6\u80fa\u5e26\u6765\u4e0d\u5c0f\u7684\u538b\u529b\uff0c\u6765\u90a3\u5ea6\u80fa\u589e\u957f\u901f\u5ea6\u4e5f\u5f00\u59cb\u653e\u6162\u3002<\/span><\/p>\n

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Opdivo<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

Opdivo\u7531BMS\u548c\u65e5\u672c\u5c0f\u91ce\u516c\u53f8\u5171\u540c\u5f00\u53d1\uff0c\u662fPD-1\u6291\u5236\u5242\u91cc\u9762\u7684\u201cfirst in class\u201d\uff0c\u7387\u5148\u5728\u65e5\u672c\u4e0a\u5e02\uff0c2014\u5e7412\u6708\uff0c\u7f8e\u56fdFDA\u52a0\u901f\u6279\u51c6Opdivo\u7528\u4e8e\u6cbb\u7597\u65e0\u6cd5\u624b\u672f\u5207\u9664\u6216\u5df2\u7ecf\u51fa\u73b0\u8f6c\u79fb\u4e14\u5bf9\u5176\u5b83\u836f\u7269\u65e0\u5e94\u7b54\u7684\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002\u540c\u65f6BMS\u516c\u53f8\u4e5f\u62e5\u6709\u4e86\u7b2c\u4e00\u4e2a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242CTLA-4\u5355\u6297\uff0c\u4e24\u8005\u8054\u5408\u7528\u836f\u4e8e\u9ed1\u8272\u7624\uff0c\u60a3\u8005\u7684\u4e24\u5e74\u751f\u5b58\u7387\u66f4\u662f\u9ad8\u8fbe75%\uff0c\u6bd4PD-1\u5355\u6297\u3001CTLA-4\u5355\u6297\u5355\u836f\u4f7f\u7528\u90fd\u6709\u663e\u8457\u7684\u4f18\u52bf\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u5728\u6700\u5f00\u59cb\u9002\u5e94\u75c7\u6269\u5c55\u65b9\u9762\uff0cO\u836f\u66f4\u662f\u9065\u9065\u9886\u5148\u4e8e\u6700\u5927\u7ade\u4e89\u5bf9\u624bK\u836f\uff0c\u5728\u9ed1\u8272\u7d20\u7624\u3001\u5934\u9888\u764c\u3001\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3001\u80be\u764c\u3001\u8180\u80f1\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08\u4e8c\u7ebf\uff09\u90fd\u6709\u9886\u5148\u534a\u5e74\u7684\u4f18\u52bf\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4e0d\u8fc7\uff0c16\u5e74\u5927\u89c4\u6a21\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848checkmate-026\u7684\u5931\u8d25\u7ed9K\u836f\u6709\u4e86\u8ffd\u8d76\u7684\u673a\u4f1a\u3002O\u836f\u9009\u53d6\u7684\u662fPD-L1\uff08TPS\uff1e5%\uff09\u9633\u6027\u7684NSCLC\u60a3\u8005\uff0c\u7ed3\u679c\u548c\u6807\u51c6\u5316\u7597\u65b9\u6848\u76f8\u6bd4\u5e76\u6ca1\u6709\u660e\u663e\u7684\u4f18\u52bf\uff0c\u6700\u540e\u80a1\u5e02\u52a8\u8361\uff0cBMS\u516c\u53f8\u5f53\u65e5\u80a1\u4ef7\u66b4\u8dcc\uff0c\u77ed\u77ed\u51e0\u5929\u65f6\u95f4\u8dcc\u5e45\u9ad8\u8fbe20%\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5728\u540e\u9762NSCLC\u9002\u5e94\u75c7\u6269\u5c55\u65b9\u9762\uff0cBMS\u4f30\u8ba1\u662f\u6709\u5fc3\u7406\u9634\u5f71\u4e86\uff0c\u5f00\u59cb\u4ecePD-L1\u9633\u6027\u8868\u8fbe\u8f6c\u6362\u5230\u4e86\u80bf\u7624\u57fa\u56e0\u7a81\u53d8\u8d1f\u8377TMB\u4e0a\u4e86\u3002<\/span><\/p>\n

 <\/span><\/p>\n

18\u5e74ASCO\u4f1a\u8bae\u4e0a\uff0cO\u836f\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\uff0c\u5bf9\u4e8e\u80bf\u7624\u57fa\u56e0\u7a81\u53d8\u8d1f\u8377\u5927\u4e8e10\u7684\u75c5\u53cb\uff0c\u5bf9\u6bd4\u6807\u51c6\u65b9\u6848\u5316\u7597\uff0c\u7528\u4e8e\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e00\u7ebf\u6cbb\u7597\uff0c\u4e0d\u533a\u5206PD-L1\u9633\u6027\u3001\u9634\u6027\uff0c\u4e0d\u533a\u5206\u817a\u764c\u3001\u9cde\u764c\uff0c\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0ccheckmate-227\uff0c\u5df2\u7ecf\u83b7\u5f97\u6210\u529f\uff0c\u8fdb\u5165\u4e00\u7ebfNSCLC\u4e5f\u53ea\u662f\u65e9\u665a\u95ee\u9898\u3002<\/span><\/p>\n


<\/span><\/p>\n

17\u5e74O\u836f\u5df2\u7ecf\u9ad8\u8fbe57.4\u4ebf\u7f8e\u5143\uff0c\u5df2\u7ecf\u662f\u5f53\u4e4b\u65e0\u6127\u7684\u8d85\u7ea7\u91cd\u78c5\u836f\u7269\uff0c2024\u5e74\u6709\u671b\u8fbe\u5230112.47\u4ebf\u7f8e\u5143\u7684\u4f73\u7ee9\uff0c\u548cK\u836f\u5171\u9886\u80bf\u7624\u514d\u75ab\u98ce\u9a9a\u6570\u5341\u5e74\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
<\/section>\n
\n
\n
\u56db<\/section>\n
\u4f9d\u9c81\u66ff\u5c3c<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u4f9d\u9c81\u66ff\u5c3c\u4e8e2013\u5e7411\u670813\u65e5\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u4e0a\u5e02\uff0c\u5546\u54c1\u540d\u4e3aImbruvica\u00ae\uff0c\u4e4b\u540e\u4e8e2014\u5e7410\u670821\u65e5\u83b7\u5f97\u6b27\u6d32\u836f\u7269\u7ba1\u7406\u5c40\uff08EMA\uff09\u6279\u51c6\u4e0a\u5e02\uff0c\u540e\u53c8\u4e8e2016\u5e743\u670828\u65e5\u83b7\u65e5\u672c\u533b\u836f\u54c1\u533b\u7597\u5668\u68b0\u7efc\u5408\u673a\u6784\uff08PMDA\uff09\u6279\u51c6\u4e0a\u5e02\u3002\u827e\u4f2f\u7ef4\u516c\u53f8\u8d1f\u8d23\u7f8e\u56fd\u7684\u9500\u552e\uff0c\u800c\u7f8e\u56fd\u4e4b\u5916\u7684\u9500\u552e\u5219\u7531\u5f3a\u751f\u516c\u53f8\u8d1f\u8d23\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u662fB\u7ec6\u80de\u53d7\u4f53\uff08BCR\uff09\u4fe1\u53f7\u901a\u8def\u7684\u5173\u952e\u8c03\u8282\u56e0\u5b50,\u5728\u4e0d\u540c\u7c7b\u578b\u6076\u6027\u8840\u6db2\u75c5\u4e2d\u5e7f\u6cdb\u8868\u8fbe,\u53c2\u4e0eB\u7ec6\u80de\u7684\u589e\u6b96\u3001\u5206\u5316\u4e0e\u51cb\u4ea1\u8fc7\u7a0b\u3002<\/span><\/p>\n

 <\/span><\/p>\n

BTK\u5c0f\u5206\u5b50\u6291\u5236\u5242\u7279\u5f02\u6027\u975e\u5e38\u597d\uff0c\u5728B\u7ec6\u80de\u7c7b\u6076\u6027\u80bf\u7624\u53ca\u4e00\u4e9bB\u7ec6\u80de\u514d\u75ab\u7c7b\u75be\u75c5\u7684\u6cbb\u7597\u663e\u73b0\u51fa\u975e\u5e38\u597d\u7684\u4f18\u52bf\uff0cBTK\u6291\u5236\u5242\u4e5f\u56e0\u6b64\u6210\u4e3a\u4e86\u8840\u6db2\u7624\u5e02\u573a\u524d\u666f\u6700\u597d\u7684\u836f\u7269\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u77ed\u77ed\u4e09\u5e74\u65f6\u95f4\uff0c\u4f9d\u9c81\u66ff\u5c3c\u5e74\u9500\u552e\u989d\u5c31\u5df2\u7ecf\u8fc8\u5165\u8d85\u7ea7\u91cd\u78c5\u836f\u7269\u884c\u5217\uff0c17\u5e74\u9ad8\u8fbe44.66\u4ebf\u7f8e\u5143\uff0c\u672a\u6765\u4e94\u5e74\u4f9d\u65e7\u4fdd\u630117%\u9ad8\u901f\u589e\u957f\u7684\u901f\u5ea6\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
<\/section>\n
\n
\n
\u4e94<\/section>\n
Ibrance<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

Ibrance\u662f\u4e00\u79cd\u53e3\u670d\u7684\u7ec6\u80de\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u6fc0\u9176\uff08CDK4\/ CDK6\uff09\u5c0f\u5206\u5b50\u6291\u5236\u5242\u3002\u8be5\u836f\u57282015\u5e742\u67083\u65e5\u88ab\u83b7\u6279\u4e0e\u6765\u66f2\u5511\u8054\u5408\u7528\u836f\uff0c\u7528\u4e8e\u6cbb\u7597\u7edd\u7ecf\u540e\u5973\u6027\u60a3\u8005\u7684\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08ER+\uff09\u53ca\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u9634\u6027\uff08HER2-\uff09\u7684\u665a\u671f\u4e73\u817a\u764c\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u4e73\u817a\u764c\u662f\u5973\u6027\u53d1\u75c5\u7387\u6700\u9ad8\u7684\u80bf\u7624\uff0c\u60a3\u8005\u4f53\u5185\u7684\u96cc\u6fc0\u7d20\uff08ER\uff09\u53d7\u4f53\u3001\u5b55\u6fc0\u7d20\u53d7\u4f53\uff08PR\uff09\u548c\u4eba\u7c7b\u8868\u76ae\u751f\u957f\u56e0\u5b50\uff08HER2\uff09\u53d7\u4f53\u5f80\u5f80\u4f1a\u8fc7\u5ea6\u8868\u8fbe\u3002\u96cc\u6fc0\u7d20\u548c\u5b55\u6fc0\u7d20\u53d7\u4f53\u7edf\u79f0\u4e3a\u6fc0\u7d20\u53d7\u4f53HR\u3002\u4e34\u5e8a\u4e0a\u4f1a\u6839\u636e\u80bf\u7624\u7ec4\u7ec7\u4e2d\u57fa\u56e0\u8868\u8fbe\u53ca\u86cb\u767d\u6c34\u5e73\u5c06\u4e73\u817a\u764c\u5206\u6210\u56db\u7c7b\uff08+\u8868\u793a\u9633\u6027\uff0c-\u8868\u793a\u9634\u6027\uff09\uff1a<\/span><\/p>\n

Luminal A\u578b\uff0c\uff08HR+\/HER2-\uff09\u4e73\u817a\u764c\uff1b<\/span><\/p>\n

Luminal B\u578b\uff0c\uff08HR+\/HER2+\uff09\u4e73\u817a\u764c\uff1b<\/span><\/p>\n

HER2\u9ad8\u8868\u8fbe\u578b\uff0c\uff08HR-\/HER2+\uff09\u4e73\u817a\u764c\uff1b<\/span><\/p>\n

Basal like,\uff08HR-\/HER2-\uff09\u4e73\u817a\u764c\uff0c\u4e5f\u5c31\u662f\u6211\u4eec\u5e38\u8bf4\u7684\u4e09\u9634\u6027\u4e73\u817a\u764c\uff1b<\/span><\/p>\n

 <\/span><\/p>\n

Luminal A\u578b\uff0c\uff08HR+\/HER2-\uff09\u4e73\u817a\u764c\u662f\u53d1\u75c5\u7387\u6700\u9ad8\u7684\u4e9a\u578b\uff0c\u5360\u6bd4\u7ea6\u4e3a60%\u3002\u4e4b\u524d\uff0c\u4e34\u5e8a\u4e00\u7ebf\u7528\u836f\u6765\u66f2\u5511\uff08\u53ef\u4ee5\u964d\u4f4e\u96cc\u6fc0\u7d20\u6c34\u5e73\uff09\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u53ea\u670914.5\u4e2a\u6708\uff0c\u800cIbrance\u8054\u5408\u6765\u66f2\u5511\u4e4b\u540e\u4e2d\u4f4dPFS\u9ad8\u8fbe24.8\u4e2a\u6708\u3002Ibrance\u51ed\u501f\u5982\u6b64\u6709\u6548\u7684\u7597\u6548\uff0c\u6beb\u65e0\u7591\u95ee\u6210\u4e3a\u4e86\u4e73\u817a\u764c\u5e02\u573a\u7684\u5934\u724c\u3002\u4e0a\u5e02\u7b2c\u4e00\u5e74\u9500\u552e\u989d\u5c31\u5df2\u7ecf\u8fbe\u5230\u4e867.23\u4ebf\u7f8e\u5143\u7684\u6210\u7ee9\uff0c\u662f\u540d\u526f\u5176\u5b9e\u7684\u8d85\u7ea7\u91cd\u78c5\u836f\u7269\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
<\/section>\n
\n
\n
\u516d<\/section>\n
Darzalex<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

2015\u5e7411\u6708\uff0c\u5f3a\u751f\u516c\u53f8Darzalex\u6ce8\u5c04\u6db2\u83b7\u5f97\u7f8e\u56fdFDA\u52a0\u901f\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e09\u79cd\u6cbb\u7597\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u3002Darzalex\uff08CD38\u5355\u6297\uff09\u662f\u4e00\u79cd\u6297CD38\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u7ed3\u5408\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7ec6\u80de\u4e0a\u7684CD38\u5e76\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\uff0c\u4ece\u800c\u6740\u4f24\u80bf\u7624\u7ec6\u80de\uff0c\u4e5f\u662f\u9996\u4e2a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u5355\u6297\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u6700\u521d2015\u5e74\u5e95\u4e0a\u5e02\u65f6\u662f\u4f5c\u4e3a\u56db\u7ebf\u836f\u7269\u4f7f\u7528\uff0c\u6b64\u540e\u4e24\u5e74\u53c8\u9646\u7eed\u6269\u5927\u5230\u4e8c\u7ebf\u7528\u836f\u548c\u4e09\u7ebf\u7528\u836f\uff0c\u4e0a\u5e022\u5e74\u540e\u4fbf\u6210\u4e3a\u5e74\u9500\u552e\u989d12\u4ebf\u7f8e\u5143\u7684\u91cd\u78c5\u836f\u7269\u3002<\/span><\/p>\n

 <\/span><\/p>\n

Darzalex\u6700\u5927\u7684\u7ade\u4e89\u5bf9\u624b\u662f\u65b0\u57fa\u516c\u53f8\u6765\u90a3\u5ea6\u80fa\uff0c\u4e5f\u662f17\u5e74\u6700\u7545\u9500\u7684\u80bf\u7624\u836f\u7269\uff0c\u4e00\u7ebf\u7528\u4e8e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002<\/span><\/p>\n

 <\/span><\/p>\n

18\u5e748\u67083\u65e5Darzalex\u5df2\u7ecf\u88ab\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u6279\u51c6\u4e00\u7ebf\u7528\u836f\uff0cFDA\u65b9\u9762\u4e5f\u5728\u53bb\u5e74\u5e74\u5e95\u7533\u62a5\u4e00\u7ebf\u7528\u836f\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u9500\u552e\u65b9\u9762\uff0c\u4e0a\u5e022\u5e74\u540e\u4fbf\u6210\u4e3a\u5e74\u9500\u552e\u989d12\u4ebf\u7f8e\u5143\uff0c\u800c\u4e14\u5e74\u589e\u957f\u901f\u5ea6\u66f4\u662f\u9ad8\u8fbe25%\uff0c\u662f\u76ee\u524d\u5f3a\u751f\u516c\u53f8\u6700\u4e3a\u770b\u91cd\u7684\u80bf\u7624\u4ea7\u54c1\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
<\/section>\n
\n
\n
\u4e03<\/section>\n
Tecentriq<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

Tecentriq\u4f5c\u4e3a\u7b2c\u4e00\u4e2aPD-L1\u5355\u6297\uff0c\u4e5f\u662f\u7b2c\u4e09\u4e2aPD-1\u6291\u5236\u5242\uff08\u524d\u9762\u662f14\u5e74\u4e0a\u5e02\u7684O\u836f\u548cK\u836f\uff09\uff0c\u4e0e\u80bf\u7624\u7ec6\u80de\u6216\u80bf\u7624\u6d78\u6da6\u6027\u514d\u75ab\u7ec6\u80de\u4e0a\u7684PD-L1\u53d7\u4f53\u7ed3\u5408\uff0c\u5e76\u963b\u65ad\u5176\u4e0eT\u7ec6\u80de\u53ca\u6297\u539f\u9012\u5448\u7ec6\u80de\u4e2dPD-1\u548cB7.1\u53d7\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u89e3\u9664PD-L1\/PD-1\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\u3002<\/span><\/p>\n

 <\/span><\/p>\n

Tecentriq\u7531\u57fa\u56e0\u6cf0\u514b\uff08\u7f57\u6c0f\u7684\u5b50\u516c\u53f8\uff09\u7814\u53d1\uff0c\u4e8e2016\u5e745\u670818\u65e5\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u7528\u4e8e\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u6cbb\u7597\u6b64\u5916\uff0c Tecentriq\u4e5f\u6279\u51c6\u7528\u4e8e\u94c2\u7c7b\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u4ee5\u53ca\u63a5\u53d7EGFR\u6216ALK\u9776\u5411\u836f\u7269\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002<\/span><\/p>\n

 <\/span><\/p>\n

2018\u5e745\u6708\uff0cFDA\u6388\u4e88Tecentriq\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\uff0c\u4e0e\u8d1d\u4f10\u73e0\u5355\u6297\u3001\u7d2b\u6749\u9187\u548c\u5361\u94c2\uff08\u5316\u7597\uff09\u8054\u7528\uff0c\u4e00\u7ebf\u6cbb\u7597\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u80bf\u7624\u5e02\u573a\u7d20\u6709\u201c\u6d41\u6c34\u7684\u5de8\u5934\uff0c\u94c1\u6253\u7684\u7f57\u6c0f\u201d\uff0c\u867d\u7136\u66f2\u59a5\u73e0\u5355\u6297\u3001\u8d1d\u4f10\u73e0\u5355\u6297\u3001\u5229\u59a5\u6614\u5355\u6297\u5df2\u7ecf\u9762\u4e34\u4e13\u5229\u5371\u673a\uff0c\u7f57\u6c0f\u516c\u53f8\u4f9d\u65e7\u51ed\u501f\u5e9e\u5927\u7684\u7814\u53d1\u7ba1\u7ebf\uff0c\u662f\u80bf\u7624\u5f53\u4e4b\u65e0\u6127\u7684\u738b\u8005\u3002\u4f9d\u9760\u80bf\u7624\u9886\u57df\u7684\u6df1\u539a\u5e95\u8574\uff0c\u63a8\u51fa\u7684PD-L1\u6291\u5236\u5242Tecentriq\u5728\u4e34\u5e8a\u9002\u5e94\u75c7\u6269\u5c55\u548c\u5e02\u573a\u63a8\u5e7f\u4e0a\u66f4\u52a0\u5f97\u5fc3\u5e94\u624b\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u4ee5PD-1\u6291\u5236\u5242\u76ee\u524d\u6700\u4e3a\u706b\u70ed\u7684\u9886\u57df\u4e2d\u4e3a\u4f8b\uff0cTecentriq\u5728\u843d\u540e\u4e8eO\u3001K\u4e24\u5e74\u65f6\u95f4\uff0c\u5728\u4e00\u7ebfNSCLC\u83b7\u6279\u4e0a\u4f9d\u65e7\u4e0d\u843d\u4e0b\u98ce\uff0c\u548cO\u836f\u57fa\u672c\u4e0a\u5904\u4e8e\u540c\u4e00\u6c34\u5e73\u3002\u51ed\u501f\u6781\u9ad8\u7684\u589e\u957f\u901f\u5ea6\uff0c2024\u5e74\u6709\u671b\u8fbe\u523060\u4ebf\u7f8e\u5143\u7684\u6210\u7ee9\uff0c\u662fPD-1\u6291\u5236\u5242\u6700\u540e\u4e00\u4e2a\u8d85\u7ea7\u91cd\u78c5\u836f\u7269\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
<\/section>\n
\n
\n
\u516b<\/section>\n
\u5e15\u59a5\u73e0\u5355\u6297<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u5e15\u59a5\u73e0\u5355\u6297\u662f\u7f57\u6c0f\u516c\u53f8\u7684\u7b2c\u4e8c\u6b3eHER2\u5355\u6297\uff0c\u5176\u9776\u5411\u4e8e\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\u86cb\u767d\uff08HER2\uff09\uff0c\u963b\u65ad\u7ec6\u80de\u5468\u671f\u5e76\u8bf1\u5bfc\u51cb\u4ea1\uff0c\u57282012\u5e746\u67088\u65e5\u88abFDA\u6279\u51c6\u7528\u4e8eHER2\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u3002 \u6700\u5f00\u59cb\u5e15\u59a5\u73e0\u5355\u6297\u662f\u4e3a\u4e86\u5e94\u5bf9\u66f2\u59a5\u73e0\u5355\u6297\u4e13\u5229\u5230\u671f\u7684\u5371\u673a\uff0c\u5728\u540e\u671f\u4e34\u5e8a\u4f7f\u7528\u4e2d\u6ca1\u60f3\u5230\u6548\u679c\u66f4\u6709\u4f18\u52bf\u3002\uff08\u4e73\u817a\u764c\u5206\u7c7b\u53ef\u4ee5\u5f80\u4e0a\u770bTOP5\uff09<\/span><\/p>\n

 <\/span><\/p>\n

HER2\u9633\u6027\u75c5\u4eba\u670970%\u5de6\u53f3\u54cd\u5e94\u8d6b\u8d5b\u6c40\uff0c\u52a0\u4e0a\u5e15\u59a5\u73e0\u5355\u6297\u4ee5\u540e\uff0c\u5219\u670980%\u75c5\u4eba\u54cd\u5e94\u3002\u4e09\u8054\u7ed9\u836f\u4e2d\uff0c\u75c5\u4eba\u7684\u751f\u5b58\u671f\u663e\u8457\u5ef6\u957f\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f\u5ef6\u957f\u4e8616\u4e2a\u6708\u5de6\u53f3\uff0856.5 vs 40.8\uff09\u3002\u5e15\u59a5\u73e0\u5355\u6297+ \u66f2\u59a5\u73e0\u5355\u6297+\u5316\u7597\u662fHer2+\u4e73\u817a\u764c\u7684\u672f\u524d\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff0c\u800c\u4e14\u5e15\u59a5\u73e0\u5355\u6297\u57282017\/12\/20\u88abFDA\u6279\u51c6\u7528\u4e8eHer2+\u4e73\u817a\u764c\u7684\u8f85\u52a9\u7528\u836f\uff08\u672f\u540e\uff09\uff0c\u53ef\u4ee5\u8986\u76d6Her2+\u4e73\u817a\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u5168\u7a0b\u6cbb\u7597\uff0c\u7528\u836f\u5468\u671f\u663e\u8457\u5ef6\u957f\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
<\/section>\n
\n
\n
\u4e5d<\/section>\n
\u6069\u6742\u9c81\u80fa<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u6069\u6742\u9c81\u80fa\u7531Medivation\u548c\u5b89\u65af\u6cf0\u6765\u5408\u4f5c\u7814\u53d1\uff0c\u4e8e2012\u5e748\u670831\u65e5\u88abFDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u3002\u6069\u6742\u9c81\u80fa\u662f\u96c4\u6fc0\u7d20\u53d7\u4f53\u6291\u5236\u5242\uff0c\u80fd\u591f\u51cf\u5c11\u524d\u5217\u817a\u764c\u7ec6\u80de\u7684\u589e\u503c\u548c\u8bf1\u5bfc\u5176\u6b7b\u4ea1\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u6069\u6742\u9c81\u80fa\u51ed\u501f\u5ef6\u957f\u751f\u5b58\u671f5\u4e2a\u6708\u7684\u4e34\u5e8a\u83b7\u76ca\u8fc5\u901f\u6253\u5f00\u5c40\u9762\uff0c2013\u5e74\u4fbf\u6210\u4e3a\u9500\u552e\u989d\u8fd110\u4ebf\u7f8e\u5143\u7684\u91cd\u78c5\u836f\u7269\uff0c\u662f\u76ee\u524d\u524d\u5217\u817a\u764c\u5e02\u573a\u4e0a\u6700\u4e3a\u7545\u9500\u7684\u836f\u7269\u3002\u8f89\u745e\u516c\u53f8\u6b63\u662f\u770b\u4e2d\u4e86\u6069\u6742\u9c81\u80fa\u7684\u6f5c\u529b\uff0c\u624d\u82b1\u8d39140\u4ebf\u7f8e\u5143\u62ff\u4e0bMedivation\u65d7\u4e0b\u7684\u6069\u6742\u9c81\u80fa\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
<\/section>\n
\n
\n
\u5341<\/section>\n
\u5965\u5e0c\u66ff\u5c3c<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u5965\u5e0c\u66ff\u5c3c\u662f\u7531\u963f\u65af\u5229\u5eb7\u7814\u53d1\u7684\u9776\u5411\u6297\u764c\u836f\u7269\uff0c\u4e8e2015\u5e7411\u670813\u65e5\u88abFDA\u6279\u51c6\u7528\u4e8eEGFR-T790\u7a81\u53d8\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u5c5e\u4e8e\u7b2c\u4e09\u4ee3EGFR\u6291\u5236\u5242\u3002<\/span><\/p>\n

 <\/span><\/p>\n

EGFR \u7a81\u53d8\u662f \u975e\u5c0f\u7ec6\u80de\u80ba\u764cNSCLC \u6700\u5e38\u89c1\u7684\u9a71\u52a8\u57fa\u56e0\uff0c\u5927\u7ea617%\u7684NSCLC\u60a3\u8005\u53d1\u751fEGFR\u7a81\u53d8\uff0c\u4e2d\u56fd\u7b49\u4e9a\u6d32\u56fd\u5bb6\u7a81\u53d8\u6982\u7387\u66f4\u662f\u9ad8\u8fbe30%\u4ee5\u4e0a\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u6839\u636e\u4f5c\u7528\u9776\u70b9\u3001\u7ed3\u5408\u4f4d\u70b9\u3001\u6291\u5236\u673a\u5236\u4ee5\u53ca\u4e34\u5e8a\u8010\u836f\u6027\u8868\u73b0\uff0c\u4e3b\u8981\u5c06EGFR-TKIs\u5206\u4e3a\u4e09\u4ee3\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u7b2c\u4e00\u4ee3\uff08\u53ef\u9006\u7ed3\u5408\uff09\uff1a\u5409\u975e\u66ff\u5c3c\u3001\u5384\u6d1b\u66ff\u5c3c\u3001\u57c3\u514b\u66ff\u5c3c\uff0c\u4e8c\u4ee3\uff08\u5171\u4ef7\u4e0d\u53ef\u9006\u7ed3\u5408\uff09\uff1a\u963f\u6cd5\u66ff\u5c3c\uff0c\u4e09\u4ee3\uff08\u9488\u5bf9\u4e8e\u4e00\u4ee3T790M\u7a81\u53d8\uff09\uff1a\u5965\u5e0c\u66ff\u5c3c\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u7b2c\u4e00\u4ee3\u9776\u5411\u836f\u7269\u867d\u7136\u7597\u6548\u663e\u8457\uff0c\u4f462\/3\u7684\u60a3\u8005\u90fd\u4f1a\u5728\u4f7f\u7528\u836f\u72691-2\u5e74\u51fa\u73b0\u6297\u836f\u6027\uff0c\u5e38\u89c1\u7684\u662fT790M\u7a81\u53d8\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u5965\u5e0c\u66ff\u5c3c\u80fd\u591f\u9776\u5411T790M\u7a81\u53d8\uff0c\u540c\u65f6\u5965\u5e0c\u66ff\u5c3c\u5177\u6709\u66f4\u597d\u7684\u9009\u62e9\u6027\uff0c\u5bf9\u91ce\u751f\u578b\u7684EGFR\u86cb\u767d\u4f5c\u7528\u5f31\uff0c\u6bd2\u526f\u4f5c\u7528\u66f4\u5c0f\u3002\u800c\u6700\u4e3a\u5173\u952e\u7684\u662f\uff0c\u5b83\u8fd8\u5bf9\u4e8e\u8111\u8f6c\u79fb\u6709\u6548\u300250%\u7684NSCLC\u60a3\u8005\u90fd\u4f1a\u53d1\u751f\u80bf\u7624\u8111\u8f6c\u79fb\uff0c\u4e4b\u524d\u7684EGFR\u6291\u5236\u5242\u90fd\u4e0d\u80fd\u6709\u6548\u901a\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u8fbe\u5230\u6740\u4f24\u80bf\u7624\u7684\u4f5c\u7528\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u5e02\u573a\u65b9\u9762\uff0c\u76ee\u524d\u5965\u5e0c\u66ff\u5c3c\u8fd8\u6ca1\u6709\u5b58\u5728\u7ade\u4e89\u5bf9\u624b\uff0c\u8fdb\u5c55\u6700\u5feb\u7684\u4e34\u5e8a\u836f\u7269\u5728\u7597\u6548\u4e0a\u4e5f\u4e0d\u5982\u5965\u5e0c\u66ff\u5c3c\uff0c\u518d\u52a0\u4e0a\u4e00\u4ee3EGFR\u6291\u5236\u5242\u4e13\u5229\u5230\u671f\u7684\u5f71\u54cd\uff0c\u4e00\u4ee3EGFR\u7684\u666e\u53ca\u4f1a\u5e26\u6765\u66f4\u591aT790M\u7684\u7a81\u53d8\u60a3\u8005\uff0c\u56e0\u6b64\u5965\u5e0c\u66ff\u5c3c\u7684\u5e02\u573a\u6f5c\u529b\u53ef\u8c13\u662f\u975e\u5e38\u5de8\u5927\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u53c2\u8003\u6765\u6e90\uff1aEvaluate Pharma World Preview 2018, Outlook to 2024\u3001\u516c\u53f8\u5e74\u62a5\u3002<\/span><\/p>\n


<\/p>\n

\u57f9\u8bad\u63a8\u8350<\/strong><\/span><\/p>\n

\u4e09\u5e74\u4e86\uff0c\u4e0e\u60a8\u6709\u4e2a\u7ea6\u4f1a<\/a>
<\/strong><\/span><\/p>\n

<\/span><\/a><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u80bf\u7624\uff0c\u4f9d\u9760\u4e0d\u540c\u9002\u5e94\u75c7\u8fe5\u5f02\u7684\u53d1\u75c5\u673a\u5236\uff0c\u5e9e\u5927\u7684\u60a3\u8005\u4eba\u7fa4\uff0c\u6b7b\u4ea1\u7387\u4ec5\u6b21\u4e8e\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u6210\u4e3a\u4e86\u533b\u53d1\u7684\u65b0\u5ba0\uff0c\u5e02\u573a\u7684\u98ce\u53e3\uff0c\u5173\u6ce8 […]<\/p>\n","protected":false},"author":1,"featured_media":57856,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/57855"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=57855"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/57855\/revisions"}],"predecessor-version":[{"id":57859,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/57855\/revisions\/57859"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/57856"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=57855"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=57855"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=57855"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}