{"id":58292,"date":"2018-10-29T01:00:00","date_gmt":"2018-12-07T02:32:57","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/60e971ecc3\/"},"modified":"2018-12-07T10:32:59","modified_gmt":"2018-12-07T02:32:59","slug":"60e971ecc3","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/58292\/","title":{"rendered":"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img class=\"__bg_gif\"     style=\"width: 677px !important;height: auto !important;visibility: visible !important;\"  src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/1-1544149978.gif\" alt=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\" title=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\"  \/><\/p>\n<p><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<section label=\"Copyright \u00a9 2016 playhudong All Rights Reserved.\" style=\"max-width: 100%;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"padding: 1em;max-width: 100%;box-sizing: border-box;width: 643.191px;height: auto;box-shadow: rgb(165, 165, 165) 0em 0em 0.8em;overflow: hidden;word-wrap: break-word !important;\">\n<section style=\"padding: 0.1em 0.1em 0em;max-width: 100%;display: inline-block;text-align: center;background: rgb(84, 156, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"padding: 0.5em 0.8em;max-width: 100%;color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;\u5bfc \u8bfb<\/strong>&nbsp;&nbsp;<\/p>\n<\/section>\n<\/section>\n<section style=\"margin-top: -1em;margin-right: auto;margin-left: auto;padding: 1em 0.5em;max-width: 100%;width: auto;height: auto;overflow: hidden;border-top: 0.1em dashed rgb(84, 156, 255);font-size: 1em;line-height: 1.4em;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"margin-top: 15px;max-width: 100%;min-height: 1em;line-height: 1.5em;margin-bottom: 15px;box-sizing: border-box !important;word-wrap: break-word !important;text-align: justify;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;line-height: 21px;font-family: \u5b8b\u4f53;\">\u957f\u671f\u4ee5<span style=\"max-width: 100%;line-height: 21px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6765<\/span>\uff0c\u4eba\u4eec\u8ba4\u4e3a<\/span><span style=\"max-width: 100%;line-height: 21px;\"><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8f85\u6599\u662f\u975e\u6d3b\u6027\u7269\u8d28\u3002\u4f46\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8868\u660e\uff0c\u8f85\u6599\u4e0d\u4ec5\u5bf9<\/span>API<span style=\"max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7684\u6eb6\u89e3\u5ea6\u548c\u6eb6\u51fa\u6709\u5f71\u54cd\uff0c\u5bf9<\/span>API<span style=\"max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7684\u6e17\u900f\u6027<\/span><\/span><span style=\"max-width: 100%;line-height: 21px;font-family: \u5b8b\u4f53;\">\u3001\u5438\u6536\u7b49\u6027\u8d28\u4e5f\u6709\u663e\u8457\u5f71<\/span><span style=\"line-height: 21px;max-width: 100%;font-family: \u5b8b\u4f53;\">\u54cd\u3002\u5982\u4f55\u8003\u5bdf\u8f85\u6599\u5bf9\u6eb6\u89e3\u5ea6\u548c\u6e17\u900f\u6027\u7684\u5f71\u54cd\u4e5f\u662f\u7814\u7a76\u4e2d\u9700\u8981\u91cd\u70b9\u8003\u8651\u7684\u95ee\u9898\u3002<\/span><\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI5ODI5NDE2OA==&amp;mid=2247489014&amp;idx=1&amp;sn=631c397e2d981aa01b3d6547c33a4096&amp;scene=21#wechat_redirect\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;line-height: 21px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u300a\u5c71\u68a8\u9187\u3001SLS\u5f71\u54cd\u836f\u7269\u5438\u6536\uff1f\u4e0d\u4e00\u5b9a\uff01\u300b<\/span><\/a><span style=\"font-size: 15px;line-height: 21px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e00\u6587\u62a5<\/span><span style=\"font-size: 15px;max-width: 100%;line-height: 21px;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;\">\u9053\u4e86<\/span>FDA<span style=\"font-size: 15px;max-width: 100%;\">\u5bf9<\/span><span style=\"font-size: 15px;max-width: 100%;word-wrap: break-word !important;\">14<\/span><span style=\"font-size: 15px;max-width: 100%;\">\u79cd\u5e38\u7528\u8f85\u6599\u5f71\u54cd\u836f\u7269\u5438\u6536\u7684\u7814\u7a76\u7ed3\u679c\u3002<\/span>\u5c0f\u7f16\u7ffb\u8bd1\u4e86\u4ee5\u4e0b\u76f8\u5173\u5185\u5bb9\uff0c\u4e8c\u8005\u7ed3\u5408\u8d77\u6765\u770b\u6216<span style=\"font-size: 15px;max-width: 100%;line-height: 21px;\">\u8bb8\u80fd\u7ed9\u5236\u5242<\/span>\u4eba\u4e00\u4e9b\u66f4\u591a\u601d\u8003\u3002\u672c\u6587\u4e2d\u6d89\u53ca\u4e86\u4e00\u4e9b\u6848\u4f8b\u5bf9\u6eb6\u89e3\u3001\u5438\u6536\u7684\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 25.5px;text-indent: 0pt;margin-bottom: 15px;box-sizing: border-box !important;word-wrap: break-word !important;text-align: justify;\"><span style=\"line-height: 21px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u805a\u4e59\u4e8c\u9187\uff08PEG\uff09\u3001\u805a\u7ef4\u916e\uff08PVP\uff09\u548c\u7518\u9732\u9187\u53ef\u4ee5\u589e\u52a0\u8418\u666e\u751f\u548c\u5432\u54da\u7f8e\u8f9b\u7684\u6eb6\u89e3\u5ea6\uff0c\u4f46\u662f\u5176\u6eb6\u89e3\u901f\u7387\u5374\u4e0b\u964d\uff08\u5982PEG\uff0c\u4f46\u662f\u4e0ePEG\u7684\u5206\u5b50\u91cf\u76f8\u5173\uff09\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 25.5px;text-indent: 0pt;margin-bottom: 15px;box-sizing: border-box !important;word-wrap: break-word !important;text-align: justify;\"><span style=\"line-height: 21px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">PEG   400\u5bf9\u4ee3\u8c22\u9176\uff08\u7ec6\u80de\u8272\u7d20P450\uff09\u5bf9\u8f6c\u8fd0\u5b50\u6709\u6291\u5236\u4f5c\u7528\uff0c\u5982P-\u7cd6\u86cb\u767d&nbsp;ABCB1\uff0c\u591a\u91cd\u8010\u836f\u6027\u76f8\u5173\u7684\u86cb\u767d2\uff08ABCC2\uff09\uff0c\u663e\u8457\u964d\u4f4e\u55b9\u8bfa\u916e\u7c7b\u836f\u7269\u7684\u751f\u7269\u5229\u7528\u5ea6\u3002PEG  400\u662fOATP1A2\u7684\u9009\u62e9\u6027\u5f3a\u529b\u6291\u5236\u5242\u3002\u5f71\u54cdOATP1B3\u548cOATP2B1\uff0c\u51cf\u5c0f\u80be\u5bf9\u4ed6\u6c40\u7c7b\u836f\u7269\u7684\u91cd\u5438\u6536\uff0c\u964d\u4f4e\u8fd9\u7c7b\u836f\u7269\u7684\u6d3b\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 25.5px;margin-bottom: 15px;box-sizing: border-box !important;word-wrap: break-word !important;text-align: justify;\"><span style=\"line-height: 21px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6709\u6587\u732e\u62a5\u9053\u4e8623\u79cd\u5e38\u7528\u8f85\u6599\uff0813\u79cd\u8868\u9762\u6d3b\u6027\u5242\u548c10\u79cd\u9ad8\u5206\u5b50\u6750\u6599\uff09\u5bf957%\u7684\u7ec6\u80de\u8272\u7d20P450\u9176\u6709\u6291\u5236\u6216\u589e\u5f3a\u4f5c\u7528\u3002\u8fd9\u79cd\u60c5\u51b5\u4e0b\u8fd8\u8bf4\u8f85\u6599\u662f\u60f0\u6027\u7684\uff0c\u503c\u5f97\u5546\u69b7\uff01<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 25.5px;margin-bottom: 15px;box-sizing: border-box !important;word-wrap: break-word !important;text-align: justify;\"><span style=\"font-size: 15px;line-height: 25.5px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u51e0\u4e4e\u6240\u6709\u7684\u836f\u7269\u5236\u5242\u90fd\u542b\u6709\u8f85\u6599\uff0c\u6dfb\u52a0\u8f85\u6599\u7684\u76ee\u7684\u6709\u589e\u52a0\u751f\u4ea7\u53ef\u884c\u6027\u3001\u60a3\u8005\u53ef\u63a5\u53d7\u6027\u3001\u6539\u5584\u7a33\u5b9a\u6027\u3001\u63a7\u5236\u91ca\u653e\u7b49\u3002\u8f85\u6599\u901a\u5e38\u79f0\u4e3a\u975e\u6d3b\u6027\u6210\u5206\u3002\u4f46\u662f\uff0c\u8f85\u6599\u53ef\u4ee5\u5f71\u54cd\u836f\u7269\u7684\u5438\u6536\u3001\u5206\u5e03\u3001\u4ee3\u8c22\u548c\u6d88\u9664\uff08ADME\uff09\uff0c\u8fd9\u65b9\u9762\u7684\u4fe1\u606f\u5374\u5341\u5206\u6709\u9650\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;white-space: normal;widows: 1;color: rgb(62, 62, 62);font-family: &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;line-height: 25.6px;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-left: 0.8em;max-width: 100%;box-sizing: border-box;float: left;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 2.5em;display: inline-block;vertical-align: bottom;word-wrap: break-word !important;overflow: hidden !important;\"><img    class=\"\" style=\"box-sizing: border-box;vertical-align: middle;overflow-wrap: break-word !important;visibility: visible !important;width: auto !important;height: auto !important;\"  width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/5-1544149978.png\" alt=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\" title=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\"  \/><\/section>\n<section style=\"margin-top: 0.5em;max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;font-size: 24px;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;clear: none;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;line-height: 24px;box-sizing: border-box !important;word-wrap: break-word !important;\">6.1&nbsp;<span style=\"max-width: 100%;font-family: \u5b8b\u4f53;\">\u6eb6\u89e3\u5ea6<\/span><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<p><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><img    class=\"\" style=\"box-sizing: border-box;float: left;display: inline-block;vertical-align: middle;background-color: rgb(84, 156, 255);overflow-wrap: break-word !important;visibility: visible !important;width: 670px !important;height: auto !important;\"  width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/3-1544149978.png\" alt=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\" title=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\"  \/><\/strong><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;clear: both;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;line-height: 25.5px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4f4e\u6eb6\u89e3\u5ea6\u836f\u7269\u7684\u6570\u91cf\u8d8a\u6765\u8d8a\u591a\uff0c\u9009\u62e9\u5408\u9002\u7684\u8f85\u6599\u8d8a\u6765\u8d8a\u91cd\u8981\u3002\u5177\u6709\u589e\u6eb6\u4f5c\u7528\u7684\u8f85\u6599\u7684\u5e94\u7528\u66f4\u4e3a\u5e7f\u6cdb\uff0c\u5982\u589e\u6eb6\u5242\u3001\u8868\u9762\u6d3b\u6027\u5242\u3001\u73af\u7cca\u7cbe\u3001\u78f7\u8102\u548c\u4e00\u4e9b\u9ad8\u5206\u5b50\u6750\u6599\u7b49\u3002\u5bf9\u4e8e\u5904\u65b9\u8bbe\u8ba1\u8005\u6765\u8bf4\uff0c\u9009\u62e9\u6700\u4f73\u7684\u8f85\u6599\u7ec4\u5408\u53ef\u4ee5\u89e3\u51b3\u751f\u7269\u5229\u7528\u5ea6\u3001\u7a33\u5b9a\u6027\u3001\u751f\u4ea7\u53ef\u884c\u6027\u7684\u95ee\u9898\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;line-height: 25.5px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4f46\u662f\u7ecf\u5e38\u9700\u8981\u5728\u8fd9\u4e09\u4e2a\u65b9\u9762\u505a\u4e00\u4e9b\u5e73\u8861\uff0c\u4f8b\u5982\uff0c\u8f85\u6599\u7684\u52a0\u5165\u5f80\u5f80\u53ef\u4ee5\u63d0\u9ad8\u751f\u7269\u5229\u7528\u5ea6\uff0c\u4f46\u662f\u5728\u5f88\u591a\u65f6\u5019\u4f1a\u964d\u4f4e\u5236\u5242\u7684\u7a33\u5b9a\u6027\u3002\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u9700\u8981\u91c7\u53d6\u4e00\u5b9a\u7684\u63a7\u5236\u7b56\u7565\u4ee5\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;line-height: 25.5px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u836f\u7269\u7814\u53d1\u65e9\u671f\uff0c\u8bc4\u4ef7\u8f85\u6599\u5bf9\u5019\u9009\u836f\u7269\u6eb6\u51fa\u7684\u5f71\u54cd\u662f\u6700\u4e3a\u91cd\u8981\u7684\u3002\u8fd9\u4e9b\u8f85\u6599\u5f80\u5f80\u5f71\u54cd\u591a\u6676\u578b\u6216\u6eb6\u5242\u5316\u7269\u7684\u8f6c\u53d8\u3002\u5728\u6eb6\u89e3\u5ea6\u6216\u836f\u7269\u6eb6\u51fa\u6d4b\u8bd5\u7684\u8fc7\u7a0b\u4e2d\u8fdb\u884c\u5b9e\u65f6\u5206\u6790\uff0c\u53ef\u4ee5\u66f4\u597d\u5730\u7406\u89e3\u836f\u7269\u548c\u8f85\u6599\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u8f85\u6599\u5bf9\u6eb6\u89e3\u5ea6\u7684\u5f71\u54cd\u5e38\u5e38\u5341\u5206\u590d\u6742\u3002\u8bc4\u4ef7\u53ef\u79bb\u5b50\u5316\u836f\u7269\u5728\u591a\u4e2apH\u7684\u6eb6\u89e3\u5ea6\u662f\u5fc5\u8981\u7684\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;line-height: 25.5px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">Avdeef\u7684\u7b49\u4eba\u5efa\u8bae\u6839\u636e\u8fd9\u4e9b\u6570\u636e\u5efa\u7acb\u6eb6\u89e3\u5ea6-\u8f85\u6599\u5206\u7ea7\u56fe<\/span><span style=\"font-size: 15px;\"><span style=\"font-size: 15px;max-width: 100%;line-height: 25.5px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;\">\u3002\u5bf9\u4e8e\u7ed9\u5b9a\u7684\u5316\u5408\u7269\uff0c\u5206\u7ea7\u56fe\u6709\u52a9\u4e8e\u5bf9\u8f85\u6599\u8fdb\u884c\u6392\u5e8f\u3002\u5728\u67d0\u4e9b<\/span>pH<span style=\"font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;\">\u4e0b\uff0c<\/span><\/span><span style=\"font-size: 15px;line-height: 24px;font-family: \u5b8b\u4f53;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4f1a\u51fa\u73b0\u836f\u7269\u805a\u96c6\u4f53\uff0c\u5bf9\u6eb6\u51fa\u6709\u663e\u8457\u5f71\u54cd\u3002<\/span><span style=\"font-size: 15px;max-width: 100%;line-height: 25.5px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;\">\u805a\u96c6\u4f53\u7531\u4e0d\u5e26\u7535\u7684\u5316\u5408\u7269\u5f62\u6210\uff0c\u6709\u4e9b\u60c5\u51b5\u4e0b\u5219\u7531\u9633\u79bb\u5b50\u6216\u9634\u79bb\u5b50\u5f62\u6210\u3002\u8fd8\u6709\u4e9b<\/span>API<span style=\"font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;\">\u53ef\u4ee5\u5728\u5f88\u5e7f\u5bbd\u7684<\/span><span style=\"font-size: 15px;max-width: 100%;word-wrap: break-word !important;\">pH<\/span><span style=\"font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;\">\u8303\u56f4\u5185\u5f62\u6210\u6df7\u5408\u7684\u836f\u7269\u805a\u96c6\u4f53\u3002\u7814\u7a76\u53d1\u73b0\u5404\u79cd\u4e0d\u540c\u7684\u8f85\u6599\u4f7f\u5f97\u8fd9\u4e9b\u836f\u7269\u805a\u96c6\u4f53\u7684\u5f62\u6210\u66f4\u4e3a\u6df7\u4e71\uff0c\u8fd9\u4e5f\u8fdb\u4e00\u6b65\u8bf4\u660e\u8f85\u6599\u5bf9\u836f\u7269\u6eb6\u89e3\u5ea6\u7684\u5f71\u54cd\u5341\u5206\u590d\u6742\u3002<\/span><\/span><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd9\u79cd\u590d\u6742\u6027\u4f7f\u5f97\u5bf9\u836f\u7269\u6eb6\u89e3\u5ea6\u7684\u9884\u6d4b\u9762\u4e34\u5de8\u5927\u7684\u6311\u6218\u3002\u91c7\u7528\u8ba1\u7b97\u673a\u6a21\u62df\u7684\u65b9\u5f0f\u53ef\u4ee5\u9884\u6d4b\u836f\u7269\u5728\u6c34\u4e2d\u7684\u6eb6\u89e3\u5ea6\uff0c\u4f46\u6a21\u62df\u8f85\u6599\u7684\u5f71\u54cd\u5e38\u5e38\u9700\u6309\u7167\u8f85\u6599\u7684\u7c7b\u522b\u8fdb\u884c\u5206\u7c7b\u3002\u4f8b\u5982\u52a9\u6eb6\u5242\u7b49\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u91c7\u7528\u70ed\u529b\u5b66\u6a21\u578b\uff0c\u901a\u8fc7\u8ba1\u7b97\u56fa-\u6db2\u5e73\u8861\u6001\u53ef\u4ee5\u9884\u6d4b\u4e00\u822c\u836f\u7269\u5728\u8f85\u6599\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\u7684\u6eb6\u89e3\u5ea6\u3002\u7ecf\u5178\u7684Scatchard-Hildrand\u65b9\u6cd5\u5728\u5236\u836f\u5b66\u4e2d\u7ecf\u5e38\u8fd0\u7528\uff0c\u540c\u65f6\u4e5f\u88ab\u8fdb\u4e00\u6b65\u53d1\u5c55\uff0c\u4ee5\u4fbf\u5728\u6781\u6027\u6eb6\u5242\u4e2d\u505a\u51fa\u66f4\u597d\u5730\u9884\u6d4b\u3002\u5728\u8f85\u6599\u5bf9\u5171\u6eb6\u6027\u548c\u6eb6\u89e3\u5ea6\u5f71\u54cd\u7684\u8ba1\u7b97\u673a\u6a21\u62df\u7b5b\u9009\u8fc7\u7a0b\u4e2d\uff0c\u5e38\u5e38\u91c7\u7528\u6eb6\u89e3\u5ea6\u53c2\u6570\u3002\u6700\u8fd1\uff0c\u771f\u6eb6\u5242\u7c7b\u5bfc\u4f53\u5c4f\u853d\u6a21\u578b\uff08Conductor-like  Screening Model for Real Solvents, COSMO-RS\uff09\u88ab\u7528\u4e8e\u5904\u7406\u65e9\u671f\u5904\u65b9\u7b5b\u9009\u7684\u8f85\u6599\u9009\u62e9\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">Paus\u7b49\u4eba\u91c7\u7528\u65e0\u89c4\u94fe\u7edf\u8ba1\u76f8\u5173\u7684\u6d41\u4f53\u539f\u7406\uff08PC-SAFT\uff09\u6cd5\u7814\u7a76\u4e86\u8f85\u6599\u5bf9\u5236\u5242\u6eb6\u51fa\u548c\u6eb6\u89e3\u5ea6\u7684\u5f71\u54cd\u3002\u4ed6\u4eec\u9009\u62e9\u4e86\u4e24\u4e2a\u9634\u79bb\u5b50\u836f\u7269\u4f5c\u4e3a\u6a21\u578b\uff08\u8418\u666e\u751f\u548c\u5432\u54da\u7f8e\u8f9b\uff09\uff0c\u6d4b\u5b9a\u4e86\u5176\u5728\u805a\u4e59\u4e8c\u9187\uff08PEG\uff09\u3001\u805a\u7ef4\u916e\uff08PVP\uff09\u548c\u7518\u9732\u9187\u5b58\u5728\u4e0b\u7684\u6eb6\u89e3\u5ea6\u3002\u91c7\u7528PC-SAFT\u539f\u7406\u8fdb\u884c\u9884\u6d4b\uff0c\u5728\u8fd9\u4e9b\u8f85\u6599\u7684\u5b58\u5728\u4e0b\uff0c\u53ef\u80fd\u589e\u52a0\u6eb6\u89e3\u5ea6\u3002\u6709\u8da3\u5730\u662f\uff0c\u5c3d\u7ba1\u5728\u8f85\u6599\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\uff0c\u4e24\u79cdAPI\u7684\u6eb6\u89e3\u5ea6\u589e\u52a0\uff0c\u4f46\u662f\u5176\u6eb6\u89e3\u901f\u7387\u5374\u4e0b\u964d\uff08\u5982PEG\uff0c\u4f46\u662f\u4e0ePEG\u7684\u5206\u5b50\u91cf\u76f8\u5173\uff09\u3002\u4f5c\u8005\u8ba4\u4e3a\u8fd9\u4e9b\u4e0d\u540c\u662f\u56e0\u4e3a\u9ad8\u5206\u5b50\u6750\u6599\u4e2d\u7684\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u4ee5\u53ca\u8f85\u6599\u5bf9\u53cd\u5e94\u901f\u7387\u5f71\u54cd\u7684\u5171\u540c\u4f5c\u7528\uff0c\u5373\u8868\u9762\u53cd\u5e94\u7684\u901f\u7387\u548cAPI\u7684\u6eb6\u51fa\u901f\u7387\u7684\u5171\u540c\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd9\u4e2a\u4f8b\u5b50\u5c55\u793a\u4e86\u73b0\u4ee3\u70ed\u529b\u5b66\u6a21\u578b\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u66f4\u597d\u5730\u7406\u89e3\u8f85\u6599\u5bf9\u836f\u7269\u6eb6\u89e3\u5ea6\u548c\u6eb6\u51fa\u7684\u5f71\u54cd\u3002\u867d\u7136\u5bf9\u836f\u7269\u6eb6\u51fa\u7684\u975e\u5e73\u8861\u6a21\u62df\u4ecd\u7136\u662f\u5341\u5206\u5b66\u672f\u5316\uff0c\u4f46\u662f\u4e00\u4e9b\u5236\u836f\u516c\u53f8\u5df2\u7ecf\u5f00\u59cb\u91c7\u7528\u73b0\u4ee3\u70ed\u529b\u5b66\u6a21\u578b\u65b9\u6cd5\u7528\u4e8e\u8f85\u6599\u7684\u9009\u62e9\u3002\u53ef\u4ee5\u9884\u89c1\u7684\u662f\uff0c\u70ed\u529b\u5b66\u6a21\u578b\u548c\u9ad8\u901a\u91cf\u7684\u6eb6\u89e3\u5ea6\u6d4b\u8bd5\u5728\u5236\u836f\u5de5\u4e1a\u65b9\u9762\u4f1a\u8d8a\u53d1\u91cd\u8981\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u9ad8\u901a\u91cf\u6eb6\u89e3\u5ea6\u5b9e\u9a8c\u5305\u62ec\u5728\u751f\u7269\u76f8\u5173\u7684\u4ecb\u8d28\u4e2d\u7684\u6eb6\u89e3\u5ea6\uff0c\u4f8b\u5982\u7981\u98df\u72b6\u6001\u4e0b\u6a21\u62df\u80a0\u6db2\uff08FaSSIF\uff09\u3002\u8fd9\u4e9b\u4ecb\u8d28\u4e2d\u6709\u80c6\u6c41\u548c\u78f7\u8102\u3002\u5b83\u4eec\u53ef\u4ee5\u4e0e\u8f85\u6599\u76f8\u4e92\u4f5c\u7528\uff0c\u589e\u52a0\u836f\u7269\u7684\u6eb6\u89e3\u5ea6\u3002\u53e6\u4e00\u4e2a\u9700\u8981\u8003\u8651\u7684\u662f\u6eb6\u6db2\u4e2d\u7684\u836f\u7269\u5728\u8f85\u6599\u5b58\u5728\u60c5\u51b5\u4e0b\u7684\u8fc7\u9971\u548c\u4e0e\u6c89\u6dc0\u3002\u4e00\u4e9b\u7cfb\u7edf\u53ef\u4ee5\u5728\u80c3\u80a0\u9053\u5185\u5448\u836f\u7269\u7684\u8fc7\u9971\u548c\u72b6\u6001\uff0c\u4fc3\u8fdb\u5438\u6536\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u76ee\u524d\u5df2\u7ecf\u53d1\u8868\u4e86\u4e00\u4e9b\u5173\u4e8e\u836f\u7269\u8fc7\u9971\u548c\u8f85\u6599\u5982\u4f55\u5f71\u54cd\u836f\u7269\u6eb6\u89e3\u5ea6\u7684\u7efc\u8ff0\u3002\u5728\u7814\u53d1\u65e9\u671f\u6d4b\u5b9a\u8f85\u6599\u5bf9\u8fc7\u9971\u548c\u6001\u7684\u5f71\u54cd\uff0c\u6709\u5229\u4e8e\u8f85\u6599\u9009\u62e9\u548c\u5904\u65b9\u5f00\u53d1\u3002<\/span><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;white-space: normal;widows: 1;color: rgb(62, 62, 62);font-family: &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;line-height: 25.6px;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-left: 0.8em;max-width: 100%;box-sizing: border-box;float: left;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 2.5em;display: inline-block;vertical-align: bottom;word-wrap: break-word !important;overflow: hidden !important;\"><img    class=\"\" style=\"box-sizing: border-box;vertical-align: middle;overflow-wrap: break-word !important;visibility: visible !important;width: auto !important;height: auto !important;\"  width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/1-1544149978.png\" alt=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\" title=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\"  \/><\/section>\n<section style=\"margin-top: 0.5em;max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;font-size: 24px;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;clear: none;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">6.2.&nbsp;<span style=\"max-width: 100%;font-family: \u5b8b\u4f53;\">\u6e17\u900f\u6027<\/span><\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<p><img    class=\"\" style=\"box-sizing: border-box;float: left;display: inline-block;vertical-align: middle;background-color: rgb(84, 156, 255);overflow-wrap: break-word !important;visibility: visible !important;width: 670px !important;height: auto !important;\"  width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/6-1544149979.png\" alt=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\" title=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\"  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;clear: both;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e00\u4e9b\u590d\u6742\u7684\u836f\u7269\u6e17\u900f\u6027\u6a21\u578b\uff0c\u4f8b\u5982\u4e4c\u8f9b\u6269\u6563\u5ba4\u6a21\u578b\uff08Ussing  diffusion chamber&nbsp;\uff09\u6216\u8005\u662f\u539f\u4f4d\u704c\u6ce8\u7814\u7a76\uff08in situ perfusion  study\uff09\uff0c\u90fd\u662f\u201c\u52b3\u52a8\u5bc6\u96c6\u578b\u201d\u7684\uff0c\u4e0d\u592a\u9002\u7528\u4e8e\u7814\u7a76\u8f85\u6599\u7684\u5f71\u54cd\u3002\u5236\u836f\u516c\u53f8\u901a\u5e38\u91c7\u7528\u5e73\u884c\u4eba\u5de5\u819c\u6e17\u900f\u5206\u6790\uff08PAMPA\uff09\u6cd5\u3002\u4e0d\u540c\u7684PAMPA\u6cd5\u5e94\u7528\u5e7f\u6cdb\uff0c\u5176\u6e17\u900f\u6027\u7ed3\u679c\u4e0e\u4eba\u4f53\u5185\u6570\u636e\u5448\u76f8\u5173\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4f46\u662f\uff0c\u819c\u6e17\u900f\u4ec5\u80fd\u6d4b\u8bd5\u88ab\u52a8\u6269\u6563\u3002\u88ab\u52a8\u6269\u6563\u5bf9\u4e8e\u5927\u591a\u6570\u836f\u7269\u5438\u6536\u7684\u5f71\u54cd\u662f\u503c\u5f97\u63a2\u8ba8\u7684\u3002\u4e3a\u4e86\u8bc4\u4ef7\u836f\u7269\u7684\u4e3b\u52a8\u8fd0\u8f93\uff0c\u4e00\u4e9b\u5236\u836f\u516c\u53f8\u91c7\u7528\u57fa\u4e8e\u7ec6\u80de\u5206\u6790\uff08\u4f8b\u5982Caco-2\uff0cMDCK\uff09\u7684\u9ad8\u901a\u91cf\u7b5b\u9009\u3002\u8fd9\u4e9b\u201c\u8d44\u6e90\u5bc6\u96c6\u201d\u7684\u6d4b\u8bd5\u5206\u6790\u901a\u5e38\u4e0d\u53ef\u66ff\u4ee3\uff0c\u4f46\u8fd9\u5bf9\u4eba\u5de5\u819c\u6269\u6563\u662f\u91cd\u8981\u8865\u5145\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">Bendels\u7b49\u4eba\u7814\u7a76pH\u503c\u548c\u6c34\u6eb6\u6db2\u8fb9\u754c\u5c42\u5982\u4f55\u5f71\u54cd\u7279\u5b9a\u836f\u7269\u7684\u6eb6\u89e3\u5ea6\u548c\u6e17\u900f\u6027\uff0c\u8bc4\u4ef7\u4e86\u51e0\u79cd\u8f85\u6599\u5982\u4f55\u5f71\u54cd\u88ab\u52a8\u6269\u6563\u3002\u4ed6\u4eec\u8bc4\u4ef7\u4e86\u51e0\u79cd\u5173\u952e\u8f85\u6599\uff08\u5982\u725b\u78fa\u80c6\u9178\u94a0\uff0c\u7f9f\u4e19\u57fa-\u03b2-\u73af\u7cca\u7cbe\uff0c\u6c2f\u5316\u94be\uff0c\u805a\u4e59\u4e8c\u9187\uff0cN-\u7532\u57fa\u5421\u54af\u70f7\u916e\uff0c\u805a\u4e59\u4e8c\u9187400\uff09\u5bf9\u8fd9\u4e24\u4e2a\u53c2\u6570\u7684\u5f71\u54cd\uff0c\u5e76\u7ed8\u5236\u4e86\u5206\u7ea7\u793a\u610f\u56fe\u3002\u5178\u578b\u7684\u60c5\u51b5\u662f\uff0c\u8f85\u6599\u4f1a\u964d\u4f4e\u6e17\u900f\u6027\uff0c\u4f46\u662f\u8fd9\u79cd\u964d\u4f4e\u4e0e\u589e\u52a0\u6eb6\u89e3\u5ea6\u5e76\u4e0d\u6210\u7edd\u5bf9\u7684\u76f8\u53cd\u8d8b\u52bf\u3002API\u663e\u793a\u51fa\u4e0d\u540c\u7684\u201c\u5438\u6536\u6f5c\u80fd\u201d\uff08\u88ab\u8fd9\u4e9b\u8f85\u6599\u4fc3\u8fdb\u5438\u6536\uff09\u5982\u4e0b\u987a\u5e8f\uff1a\u514b\u9709\u5511&gt;\u7070\u9ec4\u9709\u7d20&gt;\u5b55\u916e&gt;\u53cc\u5627\u8fbe\u83ab&gt;\u683c\u5217\u672c\u8132&gt;\u7532\u706d\u9178&gt;\u5e03\u5927\u5361\u56e0&gt;\u963f\u53f8\u54aa\u5511\u3002\u6709\u8da3\u5730\u662f\uff0c\u963f\u82ef\u8fbe\u5511\u4e0e\u683c\u5217\u672c\u8132\u4e4b\u4e8e\u7f9f\u4e19\u57fa-\u03b2-\u73af\u7cca\u7cbe\u7684\u6570\u636e\u4e0e\u4f53\u5185\u7684Cmax\u6570\u636e\u4e00\u81f4\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5176\u4ed6\u4e00\u4e9b\u6587\u732e\u62a5\u9053\u4e86\u8bb8\u591a\u8868\u9762\u6d3b\u6027\u5242\u5bf9\u6e17\u900f\u6027\u6709\u5f71\u54cd\uff1a\u5410\u6e2920\uff0c\u5410\u6e2980\uff0c\u666e\u6717\u5c3c\u514bP85\uff0c\u666e\u6717\u5c3c\u514bL61\uff0c\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0\uff0c\u751f\u80b2\u915a\u805a\u4e59\u4e8c\u9187\u7425\u73c0\u9178\u916f\uff08TPGS\uff09\uff0c\u73af\u7cca\u7cbe\uff0c\u58f3\u805a\u7cd6\u548c\u4e59\u9187\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e0a\u8ff0\u8f85\u6599\u7684\u4f5c\u7528\u673a\u5236\uff0c\u5728\u5f88\u591a\u60c5\u51b5\u4e0b\uff0c\u662f\u5bf9\u836f\u7269\u8f6c\u8fd0\u4f53\u7684\u5f71\u54cd\u3002\u5982\u679c\u8bf4\u8f85\u6599\u662f\u60f0\u6027\u7684\uff0c\u8fd9\u65f6\u5019\u662f\u503c\u5f97\u5546\u69b7\u7684\u3002\u8fd9\u4e9b\u751f\u7269\u5b66\u6548\u5e94\u5e76\u4e0d\u4ec5\u9650\u4e8e\u5bf9\u836f\u7269\u5438\u6536\u7684\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5728\u4eba\u4f53\u5185\u6709\u5927\u91cf\u7684\u836f\u7269\u8f6c\u8fd0\u4f53\uff0c\u5b83\u4eec\u4e0e\u65b0\u9648\u4ee3\u8c22\u9176\u76f8\u4e92\u4f5c\u7528\uff0c\u4f7f\u5f97\u8f85\u6599\u5bf9\u8f6c\u8fd0\u5b50\u4f5c\u7528\u5b9e\u9645\u4e0a\u4f1a\u5f71\u54cd\u836f\u7269\u4ee3\u8c22\u7684\u6240\u6709\u8fc7\u7a0b\uff08ADMET\uff0c\u5438\u6536\uff0c\u5206\u5e03\uff0c\u4ee3\u8c22\uff0c\u6d88\u9664\u548c\u6bd2\u6027\uff09\u3002<\/span><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;white-space: normal;widows: 1;color: rgb(62, 62, 62);font-family: &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;line-height: 25.6px;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-left: 0.8em;max-width: 100%;box-sizing: border-box;float: left;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 2.5em;display: inline-block;vertical-align: bottom;word-wrap: break-word !important;overflow: hidden !important;\"><img    class=\"\" style=\"box-sizing: border-box;vertical-align: middle;overflow-wrap: break-word !important;visibility: visible !important;width: 40px !important;height: auto !important;\"  width=\"40\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/2-1544149979.png\" alt=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\" title=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\"  \/><\/section>\n<section style=\"margin-top: 0.5em;max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;font-size: 24px;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;clear: none;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;line-height: 24px;box-sizing: border-box !important;word-wrap: break-word !important;\">6.3&nbsp;<span style=\"max-width: 100%;font-family: \u5b8b\u4f53;\">\u4ee3\u8c22\u9176\uff08\u7ec6\u80de\u8272\u7d20<\/span><span style=\"max-width: 100%;word-wrap: break-word !important;\">P450<\/span><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;\">\uff09\u548c\u8f6c\u8fd0\u5b50<\/span><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<p><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><img    class=\"\" style=\"box-sizing: border-box;float: left;display: inline-block;vertical-align: middle;background-color: rgb(84, 156, 255);overflow-wrap: break-word !important;visibility: visible !important;width: 670px !important;height: auto !important;\"  width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/8-1544149979.png\" alt=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\" title=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\"  \/><\/strong><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;clear: both;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e00\u4e9b\u666e\u901a\u7684\u589e\u6eb6\u8f85\u6599\uff0c\u5982PEG\uff0c\u805a\u6c27\u4e59\u70ef\u84d6\u9ebb\u6cb9\u7b49\u5bf9\u4ee3\u8c22\u9176\uff08\u7ec6\u80de\u8272\u7d20P450\uff09\u5bf9\u8f6c\u8fd0\u5b50\u6709\u6291\u5236\u4f5c\u7528\uff0c\u5982P-\u7cd6\u86cb\u767d&nbsp;ABCB1\uff0c\u591a\u91cd\u8010\u836f\u6027\u76f8\u5173\u7684\u86cb\u767d2\uff08ABCC2\uff09\u3002Engel\u7b49\u4eba\u62a5\u9053\u4e86\u56db\u79cd\u666e\u901a\u7684\u589e\u6eb6\u8f85\u6599\uff08PEG  400\uff0c\u805a\u6c27\u4e59\u70ef\u84d6\u9ebb\u6cb9\uff08CrEL\uff09\uff0c\u805a\u4e59\u4e8c\u9187\u786c\u8102\u9178\u916f(SOL)\uff0c\u7f9f\u4e19\u57fa-\u03b2-\u73af\u7cca\u7cbe\uff08HPCD\uff09\u5bf9\u6709\u673a\u9634\u79bb\u5b50\u8f6c\u8fd0\u86cb\u767d\u7cfb\u7edf\u7684\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">SOL\u548cCrEL\u5bf9\u4ee5\u4e0a\u6240\u6709\u8def\u5f84\u5747\u6709\u6291\u5236\u4f5c\u7528\uff0c\u5176\u4e2d\u5bf9OATP1A2\uff0cOATP1B3\u548cOATP2B1\u7684\u6291\u5236\u6548\u5e94\u6700\u5f3a\u3002HPCD\u6291\u5236\u6240\u6709\u7684\u8f6c\u8fd0\u86cb\u767d\uff0c\u4f46\u662f\u4ee5\u5e26\u6709\u201c\u753e\u70f7\u4e3b\u94fe\u201d\u7684\u7ed3\u6784\u4e3a\u5e95\u7269\u7684\u86cb\u767d\u9664\u5916\u3002PEG  400\u662fOATP1A2\u7684\u9009\u62e9\u6027\u5f3a\u529b\u6291\u5236\u5242\u3002\u4f7f\u7528\u8fd9\u4e9b\u8f85\u6599\u4f1a\u964d\u4f4e\u53e3\u670d\u836f\u7269\u7684\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5305\u62ec\u55b9\u8bfa\u916e\u7c7b\u836f\u7269\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd9\u4e9b\u8f85\u6599\u901a\u8fc7\u6291\u5236OATP1A2\u51cf\u5c0f\u80a0\u9053\u5438\u6536\uff0c\u964d\u4f4e\u8fd9\u4e9b\u6297\u751f\u7d20\u7684\u6cbb\u7597\u6548\u679c\u3002\u5f71\u54cdOATP1B3\u548cOATP2B1\uff0c\u51cf\u5c0f\u80be\u5bf9\u4ed6\u6c40\u7c7b\u836f\u7269\u7684\u91cd\u5438\u6536\uff0c\u4ece\u800c\u964d\u4f4e\u8fd9\u7c7b\u836f\u7269\u7684\u6d3b\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6700\u8fd1\u6709\u6587\u732e\u62a5\u9053\u4e8623\u79cd\u5e38\u7528\u8f85\u6599\uff0813\u79cd\u8868\u9762\u6d3b\u6027\u5242\u548c10\u79cd\u9ad8\u5206\u5b50\uff09\u5bf923\u79cd\u666e\u901a\u7684\u7ec6\u80de\u8272\u7d20P450\u9176\u7684\u5f71\u54cd\u3002\u7ed3\u679c\u53d1\u73b0\u8fd9\u4e9b\u8f85\u6599\u81f3\u5c11\u5bf957%\u7684\u9176\u6709\u6291\u5236\u6216\u589e\u5f3a\u4f5c\u7528\u3002\u4ea7\u751f\u5f71\u54cd\u7684\u8f85\u6599\u6d53\u5ea6\u901a\u5e38\u9700\u8981\u5927\u4e8e100\u03bcM\uff0c\u8be5\u6d53\u5ea6\u5728\u5b9e\u9645\u7684\u836f\u7269\u6cbb\u7597\u8fc7\u7a0b\u79cd\u4e00\u822c\u65e0\u6cd5\u8fbe\u5230\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4f46\u662f\u4ecd\u7136\u670920%\u7684\u8f85\u6599\u4f4e\u4e8e100\u03bcM\u5373\u53ef\u4ee5\u5bf9\u8fd9\u4e9b\u9176\u4ea7\u751f\u5f71\u54cd\uff0c\u6539\u53d8\u8fd9\u4e9b\u6613\u53d7\u7ec6\u80de\u8272\u7d20P450\u9176\u5f71\u54cd\u7684\u836f\u7269\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff08\u5373\u6cbb\u7597\u5242\u91cf\u4e0d\u8db3\u6216\u4e2d\u6bd2\u98ce\u9669\u589e\u52a0\uff09\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd9\u4e9b\u53d1\u73b0\u4e0e\u65e9\u671fRen\u7b49\u4eba\u7684\u62a5\u9053\u4e00\u81f4\u3002\u4ed6\u4eec\u7814\u7a76\u4e8622\u79cd\u5e38\u7528\u8f85\u6599\uff0c\u7ed3\u679c\u53d1\u73b0\u8d85\u8fc72\/3\u7684\u8f85\u6599\u53ef\u4ee5\u5728\u4f53\u5916\u6291\u5236CYP3A4\u8d85\u8fc750%\u7684\u6d3b\u6027\uff08\u5bf9\u4e8e\u8868\u9762\u6d3b\u6027\u5242\u548c\u9ad8\u5206\u5b50\u6765\u8bf4\uff0c\u8fd9\u4e9b\u53d1\u73b0\u66f4\u4e3a\u53ef\u4fe1\uff09\u3002<\/span><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;white-space: normal;widows: 1;color: rgb(62, 62, 62);font-family: &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;line-height: 25.6px;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-left: 0.8em;max-width: 100%;box-sizing: border-box;float: left;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 2.5em;display: inline-block;vertical-align: bottom;word-wrap: break-word !important;overflow: hidden !important;\"><img    class=\"\" style=\"box-sizing: border-box;vertical-align: middle;overflow-wrap: break-word !important;visibility: visible !important;width: auto !important;height: auto !important;\"  width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/9-1544149979.png\" alt=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\" title=\"\u3010\u5e72\u8d27\u3011\u8f85\u6599\u5bf9API\u7684\u6eb6\u89e3\u5ea6\u3001\u6e17\u900f\u6027\u3001\u5438\u6536\u548c\u9996\u8fc7\u6548\u5e94\u7684\u5f71\u54cd\"  \/><\/section>\n<section style=\"margin-top: 0.5em;max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;font-size: 24px;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;clear: none;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;line-height: 24px;box-sizing: border-box !important;word-wrap: break-word !important;\">6.4.&nbsp;<span style=\"max-width: 100%;font-family: \u5b8b\u4f53;\">\u53e3\u670d\u5438\u6536<\/span><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<p><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/strong><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;clear: both;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;text-indent: 0pt;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);margin-bottom: 15px;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;font-size: 15px;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6839\u636e\u836f\u7269\u7684\u6027\u8d28\uff0c\u5176\u53e3\u670d\u5438\u6536\u7684\u7a0b\u5ea6\u548c\u53d8\u5f02\u6027\u53d6\u51b3\u4e8e\u836f\u7269\u7684\u6eb6\u89e3\u5ea6\u3001\u6eb6\u51fa\u3001\u6e17\u900f\u6027\uff08\u5305\u62ec\u4e3b\u52a8\u8f6c\u8fd0\uff09\u548c\u80c3\u80a0\u9053\u5185\u7684\u9009\u62e9\u6027\u4ee3\u8c22\u3002\u6bcf\u4e2a\u8fc7\u7a0b\u90fd\u53ef\u80fd\u88ab\u836f\u7269\u8f85\u6599\u5f71\u54cd\u3002\u5728\u5927\u591a\u6570\u5236\u836f\u516c\u53f8\uff0c\u91c7\u7528\u4f53\u5916\u8bd5\u9a8c\u83b7\u53d6\u7684\u6eb6\u89e3\u5ea6\u548c\u6e17\u900f\u6027\u6570\u636e\uff0c\u5229\u7528\u4ee5\u751f\u7406\u5b66\u4e3a\u57fa\u7840\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff08PBPK\uff09\u8fdb\u884c\u5efa\u6a21\uff0c\u5bf9\u836f\u7269\u7684\u53e3\u670d\u5438\u6536\u8fdb\u884c\u8bc4\u4ef7\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang 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17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);line-height: normal;margin-bottom: 5px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"line-height: 25.5px;max-width: 100%;font-family: \u5b8b\u4f53;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u672c\u6587\u8282\u9009\u81eaPharmaceutical  excipients-quality, regulatory and&nbsp;biopharmaceutical  considerations\uff0c\u7b2c6\u90e8\u5206Influence of excipients on solubility, permeability,  absorption and pre-systemic metabolism of the API<\/span><\/p>\n<p><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><em><span style=\"font-size: 14px;color: rgb(136, 136, 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