{"id":5882,"date":"2018-06-17T01:00:00","date_gmt":"2018-07-27T08:47:16","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e3%80%90%e7%8b%ac%e5%ae%b6%e3%80%91%e5%9b%bd%e5%86%85%e9%a6%96%e4%b8%aa%e4%b9%99%e8%82%9d%e6%8a%97%e4%bd%93%e6%96%b0%e8%8d%af%e7%94%b3%e6%8a%a5%e4%b8%b4%e5%ba%8a\/"},"modified":"2018-07-27T16:47:18","modified_gmt":"2018-07-27T08:47:18","slug":"%e3%80%90%e7%8b%ac%e5%ae%b6%e3%80%91%e5%9b%bd%e5%86%85%e9%a6%96%e4%b8%aa%e4%b9%99%e8%82%9d%e6%8a%97%e4%bd%93%e6%96%b0%e8%8d%af%e7%94%b3%e6%8a%a5%e4%b8%b4%e5%ba%8a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/5882\/","title":{"rendered":"\u3010\u72ec\u5bb6\u3011\u56fd\u5185\u9996\u4e2a\u4e59\u809d\u6297\u4f53\u65b0\u836f\u7533\u62a5\u4e34\u5e8a"},"content":{"rendered":"
\n

\"\u3010\u72ec\u5bb6\u3011\u56fd\u5185\u9996\u4e2a\u4e59\u809d\u6297\u4f53\u65b0\u836f\u7533\u62a5\u4e34\u5e8a\"<\/p>\n

\u534e\u8f89\u5b89\u5065\uff08\u5317\u4eac\uff09\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08<\/span>Huahui Health<\/span>\uff09\u662f\u4e3a\u5bf9\u63a5\u5317\u4eac\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u52a0\u5feb\u5b9e\u65bd\u56fd\u5bb6\u521b\u65b0\u9a71\u52a8\u53d1\u5c55\u6218\u7565\uff0c\u9075\u5faa\u5e02\u573a\u5316\u539f\u5219\u8fd0\u4f5c\u800c\u521b\u5efa\u7684\u65b0\u578b\u5e02\u573a\u4e3b\u4f53\u3002\u516c\u53f8\u4ee5\u5317\u4eac\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u5728\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u53ca\u76f8\u5173\u9886\u57df\u5185\u7684\u7cfb\u5217\u539f\u59cb\u79d1\u5b66\u521b\u65b0\u4e3a\u57fa\u7840\uff0c\u4ee5\u76f8\u5173\u6cbb\u7597\u836f\u7269\u7814\u53d1\u4e3a\u6838\u5fc3\u3002<\/span><\/span><\/p>\n

\"\u3010\u72ec\u5bb6\u3011\u56fd\u5185\u9996\u4e2a\u4e59\u809d\u6297\u4f53\u65b0\u836f\u7533\u62a5\u4e34\u5e8a\"<\/p>\n

\u4e0d\u96be\u770b\u51fa\u6295\u8d44\u4eba\u6709\u836f\u660e\u5eb7\u5fb7\u6295\u8d44\u57fa\u91d1\u548c\u5efa\u4fe1\u8d44\u672c\u3002<\/strong><\/p>\n

\"\u3010\u72ec\u5bb6\u3011\u56fd\u5185\u9996\u4e2a\u4e59\u809d\u6297\u4f53\u65b0\u836f\u7533\u62a5\u4e34\u5e8a\"<\/p>\n

\"\u3010\u72ec\u5bb6\u3011\u56fd\u5185\u9996\u4e2a\u4e59\u809d\u6297\u4f53\u65b0\u836f\u7533\u62a5\u4e34\u5e8a\"<\/p>\n

CRO\u57fa\u672c\u662f\u59d4\u6258\u836f\u660e\u751f\u7269\u505a\u7684\u524d\u540e\u9884\u8ba1\u5f00\u53d1\u8d39\u7528\u5927\u69822200\u4e07\u5143\uff0c\u4e0d\u5305\u542b\u5176\u4ed6\u8d39\u7528\u3002<\/strong><\/p>\n

\"\u3010\u72ec\u5bb6\u3011\u56fd\u5185\u9996\u4e2a\u4e59\u809d\u6297\u4f53\u65b0\u836f\u7533\u62a5\u4e34\u5e8a\"<\/p>\n

\"\u3010\u72ec\u5bb6\u3011\u56fd\u5185\u9996\u4e2a\u4e59\u809d\u6297\u4f53\u65b0\u836f\u7533\u62a5\u4e34\u5e8a\"<\/p>\n

\"\u3010\u72ec\u5bb6\u3011\u56fd\u5185\u9996\u4e2a\u4e59\u809d\u6297\u4f53\u65b0\u836f\u7533\u62a5\u4e34\u5e8a\"<\/p>\n

\u7531\u4ee5\u4e0a\u4e13\u5229\u53ef\u4ee5\u731c\u6d4b\u6b64\u6b21\u7533\u62a5\u4e34\u5e8a\u7684\u751f\u7269\u836f\u6297\u4f53\u4e3a\u6297\u524d<\/span>-S1 HBV\u6297\u4f53\u3002<\/span><\/span><\/strong><\/p>\n

\u800c\u53e6\u4e00\u7bc7\u4e13\u5229\u662f<\/span>hNTCP\uff08\u725b\u78fa\u80c6\u9178\u94a0\u5171\u8f6c\u8fd0\u591a\u80bd\uff09\u6291\u5236\u5242\u4e3a\u5316\u5b66\u836f\uff0c\u56fd\u5916\u4e5f\u6709\u7814\u7a76\u5982<\/span>MYR\u6709\u9650\u516c\u53f8\u7684<\/span>CN201580054357.0 HBV\u548c<\/span>HDV\u611f\u67d3\u7684\u8054\u5408\u6cbb\u7597\u3002\u56fd\u5185\u76ee\u524d\u4e5f\u6709\u4e0a\u6d77\u8d3a\u666e\u836f\u4e1a\u7684\u4e59\u809d\u6cbb\u7597\u65b0\u836f\u8d3a\u666e\u62c9\u80bd\u901a\u8fc7\u4e0e<\/span>HBV\u809d\u7ec6\u80de\u611f\u67d3\u53d7\u4f53<\/span>NTCP\u7ed3\u5408\uff0c\u963b\u65ad<\/span>HBV\u611f\u67d3\uff0c\u6253\u65ad\u73b0\u6709\u4e59\u809d\u6cbb\u7597\u4e2d\u75c5\u6bd2\u6e05\u9664\u2192\u518d\u611f\u67d3\u7684\u7ef5\u957f\u5faa\u73af\u3002\u4f7f\u5065\u5eb7\u809d\u7ec6\u80de\u9010\u6e10\u5b8c\u6210\u5bf9<\/span>HBV\u53d7\u67d3\u809d\u7ec6\u80de\u7684\u66ff\u6362\uff0c\u8fdb\u800c\u63d0\u9ad8\u6162\u6027\u4e59\u809d\u7684\u6cbb\u7597\u6548\u7387\uff0c\u751a\u81f3\u6709\u53ef\u80fd\u4f7f\u6162\u6027\u4e59\u809d\u83b7\u5f97\u5b8c\u5168\u6cbb\u6108\u3002\u8be5\u54c1\u79cd\u5df2\u4e8e<\/span>2014\u5e74<\/span>11\u6708\u53d6\u5f97\u4e86\u5316\u5b66\u836f\u54c1\u7b2c<\/span>1.1\u7c7b\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\uff0c\u76ee\u524d\u5728\u5317\u4eac<\/span>302\u533b\u9662\u5df2\u5b8c\u6210<\/span>I\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u674e\u6587\u8f89<\/span> \u535a\u58eb<\/span>: <\/strong>\u672c\u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u5174\u8da3\u96c6\u4e2d\u4e8e\u91cd\u8981\u75c5\u6bd2\u611f\u67d3\u7684\u5206\u5b50\u673a\u5236\u53ca\u5176\u9632\u6cbb\u3002\u8fd1\u5e74\u6765\uff0c\u4e3b\u8981\u81f4\u529b\u4e8e\u4e59\u809d\u75c5\u6bd2\uff08<\/span>HBV\uff09\u7814\u7a76\u3002\u4e59\u578b\u809d\u708e\u662f\u5371\u5bb3\u4eba\u7c7b\u5065\u5eb7\u7684\u4e25\u91cd\u4f20\u67d3\u75c5\u3002\u5168\u7403\u4f30\u8ba1\u6709<\/span>HBV\u611f\u67d3\u8005<\/span>2.4\u4ebf\u4eba\uff0c\u5176\u4e2d\u6211\u56fd\u7ea6\u6709<\/span>9300\u4e07\u4eba\u3002\u6162\u6027<\/span>HBV\u611f\u67d3\u662f\u5bfc\u81f4\u809d\u786c\u5316\u3001\u809d\u764c\u7684\u91cd\u8981\u75c5\u56e0\u3002\u4e01\u578b\u809d\u708e\u75c5\u6bd2\uff08<\/span>HDV\uff09\u662f<\/span>HBV\u7684\u536b\u661f\u75c5\u6bd2<\/span>,\u5728\u6240\u6709<\/span>HBV\u611f\u67d3\u8005\u4e2d\uff0c\u7ea6\u6709<\/span>1500\u4e07\u4eba\u540c\u65f6\u611f\u67d3<\/span>HDV\u3002\u6211\u4eec\u53d1\u73b0<\/span>HBV\u53ca<\/span>HDV\u611f\u67d3\u809d\u7ec6\u80de\u7684\u5173\u952e\u53d7\u4f53\u662f\u94a0\u79bb\u5b50<\/span>–\u725b\u78fa\u80c6\u9178\u5171\u8f6c\u8fd0\u86cb\u767d\uff08<\/span>NTCP\uff09\uff1b\u7a33\u5b9a\u8868\u8fbe\u4eba<\/span>NTCP\u7684<\/span>HepG2\u7ec6\u80de\u7cfb<\/span>(HepG2-NTCP)\u5df2\u6210\u4e3a<\/span>HBV\u76f8\u5173\u57fa\u7840\u75c5\u6bd2\u5b66\u7814\u7a76\u548c\u6297\u75c5\u6bd2\u836f\u7269\u7814\u53d1\u7684\u91cd\u8981\u5e73\u53f0\u3002\u76ee\u524d\uff0c\u5bf9\u4e59\u809d\u611f\u67d3\u7684\u79d1\u5b66\u7814\u7a76\u53ca\u836f\u7269\u5f00\u53d1\u5df2\u8fdb\u5165\u4e00\u4e2a\u5145\u6ee1\u751f\u673a\u7684\u65b0\u65f6\u4ee3\u3002\u672c\u5b9e\u9a8c\u5ba4\u7efc\u5408\u8fd0\u7528\u75c5\u6bd2\u5b66\uff0c\u751f\u7269\u5316\u5b66\uff0c\u514d\u75ab\u5b66\uff0c\u5316\u5b66\u751f\u7269\u5b66\u7b49\u591a\u5b66\u79d1\u65b9\u6cd5\u6df1\u5165\u5256\u6790<\/span>HBV\u53ca<\/span>HDV\u611f\u67d3\u8fc7\u7a0b\u7684\u5206\u5b50\u57fa\u7840\uff0c\u4ee5\u5e2e\u52a9\u7406\u89e3\u5176\u75c5\u7406\u673a\u5236\u3002\u6211\u4eec\u4e5f\u5e0c\u671b\u7814\u53d1\u65b0\u7684\u6297\u75c5\u6bd2\u836f\u7269\uff0c\u4e3a\u6700\u7ec8\u6709\u6548\u89e3\u9664\u60a3\u8005\u7684\u75c5\u75db\u800c\u52aa\u529b\u3002\u6b64\u5916\uff0c\u6211\u4eec\u4e5f\u4e0e\u76f8\u5173\u5b9e\u9a8c\u5ba4\u5408\u4f5c\u7814\u7a76<\/span>NTCP\/\u80c6\u9178\u7b49\u5206\u5b50\u5728\u611f\u67d3\u53ca\u673a\u4f53\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u7684\u76f8\u5173\u4f5c\u7528\u3002\uff08\u6765\u6e90\u4e8e<\/span>NIBS\u7f51\u7ad9\uff09<\/span><\/p>\n

\u56fd\u5185\u5916\u4e59\u809d\u65b0\u836f\u8fdb\u5c55<\/span><\/p>\n

<\/span><\/p>\n

\"\u3010\u72ec\u5bb6\u3011\u56fd\u5185\u9996\u4e2a\u4e59\u809d\u6297\u4f53\u65b0\u836f\u7533\u62a5\u4e34\u5e8a\"<\/p>\n

\"\u3010\u72ec\u5bb6\u3011\u56fd\u5185\u9996\u4e2a\u4e59\u809d\u6297\u4f53\u65b0\u836f\u7533\u62a5\u4e34\u5e8a\"<\/p>\n

\u76ee\u524d\u56fd\u5185\u4e5f\u6709\u6bd4\u8f83\u591a\u7684<\/span>TLR7\u6fc0\u52a8\u5242\u6cbb\u7597\u4e59\u809d\u7684\u7814\u7a76\uff0c\u4f8b\u5982\u6052\u745e\u533b\u836f\u3001\u6b63\u5927\u5929\u6674\u3001\u79d1\u4f26\u836f\u4e1a\u3001\u94f6\u674f\u6811\u3001\u793c\u6c83\u533b\u836f\u5747\u6709\u4e13\u5229\u7533\u8bf7\u3002<\/span><\/p>\n<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u7269\u7b80\u8baf <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u534e\u8f89\u5b89\u5065\uff08\u5317\u4eac\uff09\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08Huahui Health\uff09\u662f\u4e3a\u5bf9\u63a5\u5317\u4eac\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u52a0\u5feb\u5b9e\u65bd\u56fd\u5bb6\u521b\u65b0\u9a71\u52a8\u53d1 […]<\/p>\n","protected":false},"author":1,"featured_media":5883,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/5882"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=5882"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/5882\/revisions"}],"predecessor-version":[{"id":5893,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/5882\/revisions\/5893"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/5883"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=5882"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=5882"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=5882"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}