{"id":59057,"date":"2018-11-12T01:00:00","date_gmt":"2018-12-07T02:42:02","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/648ae0ef04\/"},"modified":"2018-12-07T10:42:02","modified_gmt":"2018-12-07T02:42:02","slug":"648ae0ef04","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/59057\/","title":{"rendered":"\u3010\u63a8\u8350\u3011\u836f\u54c1\u6ce8\u518c\u4e13\u5458\u5de5\u4f5c\u8be5\u600e\u4e48\u505a\uff1f\u8fd9\u4e9b\u6280\u80fd\u9700\u8981\u5f3a\u5316\u57f9\u517b"},"content":{"rendered":"
\n

\u836f\u54c1\u6ce8\u518c\u4e13\u5458\u7684\u804c\u80fd<\/span><\/strong><\/span>
<\/p>\n

\u00972016\u5e747\u670822\u65e5\u53d1\u5e03\u7684\u300a\u836f\u54c1\u6ce8\u518c\u7ba1\u7406\u529e\u6cd5\uff08\u4fee\u8ba2\u7a3f\uff09\u300b<\/strong>\u89c4\u5b9a\u5982\u4e0b\uff1a<\/span><\/p>\n

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\u0097\u836f\u54c1\u6ce8\u518c\u4e13\u5458\u5e94\u5f53\u5177\u6709\u76f8\u5e94\u7684\u4e13\u4e1a\u77e5\u8bc6\uff0c\u719f\u6089\u836f\u54c1\u6ce8\u518c\u7684\u6cd5\u5f8b\u3001\u6cd5\u89c4\u53ca\u6280\u672f\u8981\u6c42\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u836f\u54c1\u6ce8\u518c\u4e13\u5458\u5728\u4f01\u4e1a\u4e2d\u7684\u4f5c\u7528<\/span><\/strong><\/span><\/p>\n

\u00971\u3001\u836f\u54c1\u6ce8\u518c\u662f\u5236\u836f\u4f01\u4e1a\u548c\u836f\u76d1\u90e8\u95e8\u6c9f\u901a\u7684\u6865\u6881\u548c\u7ebd\u5e26\u3002\u836f\u54c1\u6ce8\u518c\u4e13\u5458\u5e94\u8be5\u5c3d\u53ef\u80fd\u7684\u5c06\u4f01\u4e1a\u7684\u7814\u7a76\u65b9\u6848\u4e0e\u8fc7\u7a0b\u5411\u5ba1\u8bc4\u4eba\u5458\u9610\u8ff0\uff0c\u5bf9\u5176\u63d0\u51fa\u7684\u95ee\u9898\u8981\u51c6\u786e\u8be6\u5c3d\u7684\u89e3\u7b54\uff0c\u540c\u65f6\u5bf9\u6ce8\u518c\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u7684\u95ee\u9898\u5e94\u53ca\u65f6\u8be2\u95ee\u76f8\u5173\u90e8\u95e8\uff0c\u4ee5\u5bfb\u6c42\u6700\u5408\u9002\u7684\u89e3\u51b3\u65b9\u6848\u3002\u0097\u0097<\/p>\n

2\u3001\u836f\u54c1\u6ce8\u518c\u662f\u5236\u836f\u4f01\u4e1a\u5185\u90e8\u5404\u804c\u80fd\u90e8\u95e8\u95f4\u7684\u6c9f\u901a\u6865\u6881\u3002\u836f\u54c1\u6ce8\u518c\u4e13\u5458\u9700\u8981\u5728\u836f\u54c1\u7814\u53d1\u8fc7\u7a0b\u4e2d\u4e0e\u5404\u90e8\u95e8\u8fdb\u884c\u826f\u597d\u7684\u534f\u8c03\u4e0e\u6c9f\u901a\uff0c\u4f7f\u4f01\u4e1a\u5185\u90e8\u5f97\u5230\u826f\u597d\u7684\u76d1\u7ba1\u3002<\/p>\n

3\u3001\u836f\u54c1\u6ce8\u518c\u4eba\u5458\u8d1f\u8d23\u5ba1\u6838\u62a5\u9001\u836f\u54c1\u6ce8\u518c\u8d44\u6599\uff0c\u4f7f\u6ce8\u518c\u7533\u8bf7\u987a\u5229\u5f97\u5230\u6279\u51c6\u3002\u5728\u5bf9\u7533\u62a5\u8d44\u6599\u8fdb\u884c\u5ba1\u6838\u65f6\uff0c\u8981\u6c42\u5bf9\u7533\u62a5\u8d44\u6599\u4e2d\u7684\u7efc\u8ff0\uff0c\u836f\u5b66\uff0c\u836f\u7406\u6bd2\u7406\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u8d44\u6599\u5747\u6709\u6240\u4e86\u89e3\uff1b\u8fd8\u8981\u53ca\u65f6\u8ddf\u8e2a\u836f\u54c1\u6ce8\u518c\u8fdb\u5ea6\uff0c\u4e0e\u836f\u76d1\u90e8\u95e8\u4fdd\u6301\u826f\u597d\u7684\u8054\u7cfb\u548c\u6c9f\u901a\u3002\u0097\u0097<\/p>\n

4\u3001\u638c\u63e1\u836f\u54c1\u6ce8\u518c\u4fe1\u606f\uff0c\u7ef4\u62a4\u4f01\u4e1a\u5229\u76ca\u3002\u836f\u54c1\u6ce8\u518c\u4e13\u5458\u5e94\u901a\u8fc7\u591a\u79cd\u9014\u5f84\uff0c\u638c\u63e1\u5173\u4e8e\u6ce8\u518c\u7684\u6700\u65b0\u52a8\u6001\uff0c\u53ca\u65f6\u529e\u7406\u836f\u54c1\u6ce8\u518c\uff0c\u907f\u514d\u56e0\u653f\u7b56\u53d8\u5316\u6216\u6ede\u540e\u6ce8\u518c\u7ed9\u4f01\u4e1a\u9020\u6210\u635f\u5931\u3002<\/p>\n


<\/p>\n

\u5de5\u4f5c\u4e2d\u9700\u5177\u5907\u7684\u6280\u80fd<\/span><\/strong><\/span><\/p>\n

1\u3001\u57fa\u672c\u8981\u6c42<\/strong>
<\/p>\n

\u9010\u5b57\u9010\u53e5\u719f\u8bfb\u300a\u836f\u54c1\u6ce8\u518c\u7ba1\u7406\u529e\u6cd5\u300b\u0097\u719f\u6089CFDA\u548cCDE\u5b98\u65b9\u7f51\u7ad9\uff0c\u5bf9\u91cc\u9762\u7684\u5404\u79cd\u6cd5\u89c4\uff0c\u7535\u5b50\u520a\u7269\uff0c\u6700\u65b0\u901a\u77e5\uff0c\u6587\u4ef6\u7b49\uff0c\u90fd\u80fd\u5feb\u901f\u53d1\u73b0\uff1b<\/p>\n

\u4e0d\u65ad\u7684\u5b66\u4e60\u6700\u65b0\u7684\u77e5\u8bc6\uff0c\u6cd5\u89c4\uff0c\u53ca\u65f6\u66f4\u65b0\u81ea\u5df1\u7684\u77e5\u8bc6\u4f53\u7cfb\uff1b<\/p>\n

\u0097\u591a\u591a\u53c2\u52a0CDE\u4e3e\u529e\u7684\u836f\u54c1\u6ce8\u518c\u76f8\u5173\u7684\u57f9\u8bad\u73ed\uff0c\u4e86\u89e3\u56fd\u5bb6\u6700\u65b0\u52a8\u6001\u53ca\u8981\u6c42\uff1b<\/p>\n

\u0097\u57f9\u517b\u826f\u597d\u7684\u6c9f\u901a\u4e0e\u534f\u8c03\u80fd\u529b\uff0c\u641e\u597d\u4e0e\u836f\u76d1\u5c40\u7684\u4eba\u9645\u5173\u7cfb\u3002<\/p>\n


<\/p>\n

2\u3001\u50a8\u5907\u5de5\u5177<\/strong>\u0097<\/p>\n

\u4e2d\u56fd\u836f\u5178\u0097\u90e8\u9881\u6807\u51c6\uff0c\u5730\u6807\u5347\u56fd\u6807\uff0c\u5730\u65b9\u6807\u51c6\uff0c\u8f6c\u6b63\u6807\u51c6\u7b49\u0097\u5404\u56fd\u836f\u5178\uff1a\u5982\u7f8e\u56fd\u836f\u5178\uff0c\u82f1\u56fd\u836f\u5178\uff0c\u6b27\u6d32\u836f\u5178\uff0c\u65e5\u672c\u836f\u5178\u7b49\uff0c\u53ef\u5728\u836f\u7269\u5728\u7ebf\u4e0a\u68c0\u7d22\uff1b<\/p>\n

\u0097\u5e38\u7528\u5de5\u5177\u4e66\uff1a\u5982\u300a\u5de5\u4e1a\u836f\u5242\u5b66\u300b\u300a\u836f\u7528\u8f85\u6599\u624b\u518c\u300b\u300a\u836f\u7406\u5b9e\u9a8c\u65b9\u6cd5\u5b66\u300b\u7b49\uff1b<\/p>\n

\u0097\u719f\u6089CNKI\uff0c\u7ef4\u666e\uff0c\u4e07\u65b9\u7b49\u6570\u636e\u5e93\u7684\u68c0\u7d22\u3002<\/p>\n


<\/p>\n

3\u3001\u6df1\u5c42\u6280\u80fd<\/strong><\/p>\n

\u52aa\u529b\u5b66\u4e60\u4e13\u4e1a\u82f1\u8bed\u548c\u65e5\u8bed\u0097\u0097 \uff1b<\/span><\/p>\n

\u719f\u6089FDA\uff0cEDQM\uff0cPMDA\u7b49\u5404\u56fd\u5b98\u65b9\u7f51\u7ad9\u0097\u0097\u719f\u6089\u5404\u56fd\u4e13\u5229\u7684\u68c0\u7d22\u4e0e\u4e0b\u8f7d\u0097\u0097\uff1b<\/p>\n

\u80fd\u4f7f\u7528\u6570\u636e\u5e93\u5feb\u901f\u627e\u5230\u67d0\u836f\u54c1\u7684\u9500\u552e\u6570\u636e\u53ca\u5e02\u573a\u5206\u6790\u62a5\u544a\u3002<\/p>\n


<\/p>\n

\u9700\u8981\u953b\u70bc\u7684\u80fd\u529b<\/span><\/strong><\/span><\/p>\n

\u201c\u4fe1\u606f\u68c0\u7d22\u80fd\u529b<\/span>\u201d<\/span><\/p>\n

\u201c\u8d44\u6599\u6574\u5408\u3001\u5f52\u7eb3\u80fd\u529b<\/span>\u201d<\/span><\/p>\n

\u201c\u5206\u6790\u89e3\u51b3\u95ee\u9898\u7684\u80fd\u529b\u0097\u0097<\/span>\u201d<\/span><\/p>\n

\u201c\u6c9f\u901a\u534f\u8c03\u7684\u80fd\u529b<\/span>\u201d<\/span><\/p>\n


<\/p>\n

\u96be\u70b9\u5206\u6790\u53ca\u6307\u5bfc\u4e00<\/span><\/strong><\/span><\/p>\n

\u96be\u70b9\uff1a\u5bf9\u653f\u7b56\u53ca\u7533\u62a5\u8981\u6c42\u7684\u628a\u63e1<\/strong><\/p>\n

\u836f\u54c1\u6ce8\u518c\u8fc7\u7a0b\u4e2d\uff0c\u9996\u5148\u9700\u8981\u5bf9\u56fd\u5bb6\u653f\u7b56\u3001\u7533\u62a5\u8981\u6c42\u6709\u8be6\u7ec6\u7684\u4e86\u89e3\uff0c\u4f46\u6b64\u8fc7\u7a0b\u4e2d\uff0c\u7ecf\u5e38\u4f1a\u51fa\u73b0\u4fe1\u606f\u7684\u6ede\u540e\u3001\u7406\u89e3\u6027\u7684\u504f\u5dee\u7b49\u95ee\u9898\u3002\u6545\u6ce8\u518c\u4e13\u5458\u9700\u65f6\u523b\u5173\u6ce8\u653f\u7b56\u53d8\u52a8\uff0c\u9605\u8bfb\u76f8\u5173\u6587\u732e\uff0c\u5e76\u4fdd\u6301\u654f\u9510\u7684\u6d1e\u5bdf\u529b\uff0c\u80fd\u591f\u51c6\u786e\u5730\u83b7\u53d6\u4fe1\u606f\u8981\u6c42\uff0c\u53ef\u7ecf\u5e38\u4e0e\u540c\u884c\u4e4b\u95f4\u8fdb\u884c\u4ea4\u6d41\uff0c\u52a0\u5f3a\u7406\u89e3\u3002<\/p>\n


<\/p>\n

\u96be\u70b9\u5206\u6790\u53ca\u6307\u5bfc\u4e8c<\/span><\/strong><\/span><\/p>\n

\u96be\u70b9\uff1a\u6ce8\u518c\u4fe1\u606f\u53ca\u6587\u732e\u7684\u67e5\u8be2\u83b7\u53d6<\/strong><\/p>\n

\u7814\u7a76\u5b9e\u9a8c\u7684\u8fdb\u884c\u3001\u6ce8\u518c\u6587\u4ef6\u7684\u64b0\u5199\u5747\u5efa\u7acb\u5728\u524d\u671f\u6587\u732e\u8c03\u7814\u57fa\u7840\u4e0a\u7684\uff0c\u8c03\u7814\u4fe1\u606f\u8d8a\u8be6\u7ec6\uff0c\u5b9e\u9a8c\u8fdb\u884c\u3001\u6587\u4ef6\u64b0\u5199\u8d8a\u987a\u5229\uff0c\u5185\u5bb9\u8d8a\u8be6\u5b9e\u3002\u8fd9\u5c31\u9700\u8981\u6ce8\u518c\u4e13\u5458\u6709\u8db3\u591f\u7684\u4fe1\u606f\u68c0\u7d22\u80fd\u529b\u53ca\u8d44\u6599\u5f52\u7eb3\u603b\u7ed3\u80fd\u529b\u3002\u5e38\u7528\u7f51\u7ad9\u5982FDA\u3001\u4e13\u5229\u5c40\u3001\u6570\u636e\u5e93\u7b49\u5e94\u8db3\u591f\u4e86\u89e3\u6570\u91cf\u8fd0\u7528\uff0c\u5b9e\u8df5\u4e2d\u4e0d\u65ad\u79ef\u7d2f\u65b0\u7684\u4fe1\u606f\u83b7\u53d6\u7f51\u7ad9\u3002<\/p>\n


<\/p>\n

\u96be\u70b9\u5206\u6790\u53ca\u6307\u5bfc\u4e09<\/span><\/strong><\/span><\/p>\n

\u96be\u70b9\uff1a\u5916\u9001\u9879\u76ee\u7684\u68c0\u9a8c<\/strong><\/p>\n

\u7531\u4e8e\u8bbe\u5907\u53ca\u8d44\u8d28\u7684\u9650\u5236\uff0c\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\u7ecf\u5e38\u6709\u4e00\u4e9b\u9879\u76ee\u9700\u8981\u9001\u81f3\u4e13\u4e1a\u673a\u6784\u8fdb\u884c\u68c0\u9a8c\uff0c\u5982\u7ed3\u6784\u786e\u8bc1\u7684\u786e\u7acb\u3002\u7ed3\u6784\u786e\u8bc1\u68c0\u6d4b\u5185\u5bb9\u9700\u6839\u636e\u7533\u62a5\u8981\u6c42\u8fdb\u884c\uff0c\u5b9e\u9645\u68c0\u6d4b\u9700\u9001\u81f3\u8d44\u8d28\u9f50\u5168\u7684\u5355\u4f4d\u8fdb\u884c\uff0c\u6ce8\u518c\u4e13\u5458\u9700\u5bf9\u7533\u62a5\u8981\u6c42\u3001\u5355\u4f4d\u8d44\u8d28\u6709\u8db3\u591f\u7684\u4e86\u89e3\uff0c\u5e76\u4e14\u6709\u826f\u597d\u7684\u6c9f\u901a\u80fd\u529b\uff0c\u4e0e\u76f8\u5173\u5355\u4f4d\u76f8\u5173\u4eba\u5458\u51c6\u786e\u7684\u6c9f\u901a\u3002<\/p>\n


<\/p>\n

\u96be\u70b9\u5206\u6790\u53ca\u6307\u5bfc\u56db<\/span><\/strong><\/span><\/p>\n

\u96be\u70b9\uff1a\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\u65e0\u6cd5\u786e\u5b9a\u7684\u5185\u5bb9<\/strong><\/p>\n

\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\u7ecf\u5e38\u4f1a\u6709\u8bb8\u591a\u95ee\u9898\u6ca1\u6709\u660e\u786e\u7684\u653f\u7b56\u8bf4\u660e\uff0c\u5982\u6742\u8d28\u9650\u5ea6\u7684\u786e\u5b9a\uff0c\u9700\u67e5\u9605\u591a\u4e2a\u76f8\u5173\u6587\u732e\u5e76\u7ed3\u5408\u5b9e\u9645\u60c5\u51b5\u8fdb\u884c\u786e\u5b9a\u3002<\/p>\n

<\/span>
<\/p>\n

\u4f8b\uff1a\u539f\u6599\u836f\u5408\u6210\u4e2d\u7ecf\u5e38\u7528\u5230\u4e09\u4e59\u80fa\uff0c\u4f46\u4e2d\u56fd\u836f\u5178\u6ca1\u6709\u89c4\u5b9a\u5b83\u7684\u6b8b\u7559\u9650\u5ea6\u3002<\/span><\/p>\n

\u56fd\u5916\u6807\u51c6\u4e2d\u627e\u5230\u4e24\u4e2a\u4f9d\u636e\uff1a<\/em><\/p>\n

1. EDQM Europe (2007) PA\/PH\/CEP(04)14R\u4e2d\u63d0\u5230Concerning residual triethylamine, a permitted daily exposure (PDE) of 3.2mg\/day giving a limit of 320 ppm (for a  10g daily dose) was calculated from repeated Dose Toxicity and Reproductive Toxicity data. This limit of 320 ppm should there for be used as a reference limit; <\/em><\/p>\n

2. 2015\u5e74\u53d1\u5e03\u7684ICH Q3C (R6)\u6307\u5bfc\u539f\u5219\uff0c\u5c06\u4e09\u4e59\u80fa\u8ba2\u5165\u4e09\u7c7b\u6eb6\u5242\uff0c\u5373\u9650\u5ea6\u4e3a0.5%\u3002\u7efc\u5408\u8fd92\u4e2a\u4f9d\u636e\uff0c\u518d\u7ed3\u5408\u5382\u5bb6\u7684\u751f\u4ea7\u5de5\u827a\uff0c\u8fdb\u884c\u591a\u6279\u68c0\u6d4b\uff0c\u6700\u7ec8\u786e\u5b9a\u662f\u5426\u5c06\u4e09\u4e59\u80fa\u8ba2\u5165\u6807\u51c6\uff0c\u9650\u5ea6\u5b9a\u591a\u5c11\u3002<\/span><\/em><\/p>\n


<\/p>\n

\u96be\u70b9\u5206\u6790\u53ca\u6307\u5bfc\u4e94<\/span><\/strong><\/span><\/p>\n

\u96be\u70b9\uff1a\u5382\u5bb6\u671f\u671b\u8981\u6c42\u4e0e\u56fd\u5bb6\u8981\u6c42\u7684\u77db\u76fe<\/strong><\/p>\n

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<\/span>1.\u6b63\u786e\u7406\u89e3\u836f\u54c1\u6ce8\u518c<\/span>\u8d44\u6599<\/span><\/span>\u5206\u7c7b\u7ba1\u7406<\/span>—\u201c\u6211\u4eec\u5360\u636e\u7684\u4f4d\u7f6e\u5e76\u4e0d\u91cd\u8981\uff0c\u91cd\u8981\u7684\u662f\u6211\u4eec\u8981\u53bb\u7684\u65b9\u5411\u201d<\/span>
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<\/span>b\u6ce8\u518c\u5206\u7c7b\u4e4b\u95f4\u7533\u62a5\u8d44\u6599\u9879\u76ee\u95f4\u7684\u5f02\u540c\u70b9<\/span>
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<\/span>3<\/span>\u836f\u54c1\u6ce8\u518c\u7533\u62a5\u7a0b\u5e8f<\/span><\/span><\/p>\n

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a\u4ec0\u4e48\u624d\u662f\u597d\u7684\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\u8d44\u6599<\/span><\/p>\n

b\u6ce8\u518c\u8d44\u6599\u5e38\u89c1\u7684\u95ee\u9898\u5206\u6790<\/span><\/p>\n

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1.MAH\u5236\u5ea6\u8bd5\u70b9\u76f8\u5173\u653f\u7b56\u8ba8\u8bba        2.\u4e00\u81f4\u6027\u8bc4\u4ef7\u76f8\u5173\u653f\u7b56\u8ba8\u8bba<\/span><\/p>\n

3.\u5173\u8054\u5ba1\u8bc4\u5ba1\u6279\u76f8\u5173\u653f\u7b56\u8ba8\u8bba       4.\u672a\u6765\u6cd5\u89c4\u5411ICH\u7684\u53d8\u5316\u8d8b\u52bf<\/span><\/p>\n

5.\u7533\u62a5\u4e0d\u540c\u9636\u6bb5\u7684\u53d8\u66f4\u7ba1\u7406\u653f\u7b56\u53ca\u5b9e\u9645\u8bc4\u4ef7\u64cd\u4f5c\u653f\u7b56\u8981\u70b9\u6307\u5f15<\/span><\/p>\n

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2.\u9879\u76ee\u89c4\u5212\u8981\u70b9\u53ca\u5e02\u573a\u9884\u671f\u8bf4\u660e<\/span><\/strong><\/p>\n

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c\u7814\u53d1\u7ed3\u679c\u3001\u8d44\u6599\u6574\u7406\u3001\u7814\u7a76\u7ed3\u679c\u5bf9\u6bd4\u5206\u6790\u6c47\u603b\u6848\u4f8b\u89e3\u6790–\u4e13\u5bb6\u4e4b\u95f4\u7684\u5bf9\u8bdd<\/span><\/p>\n

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3.\u6ce8\u518c\u7ba1\u7406<\/span><\/strong><\/p>\n

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b\u53d8\u66f4\u7ba1\u7406\u7684\u63d0\u524d\u9884\u5224\u4e0e\u540e\u7eed\u53d8\u66f4\u98ce\u9669\u5206\u6790\u53ca\u5bf9\u6bd4\u7814\u7a76\u6cd5\u5f8b\u8981\u6c42\u6848\u4f8b\u89e3\u6790<\/span><\/p>\n

c\u7edd\u4e0d\u80fd\u89e6\u53d1\u7684\u884c\u4e3a–\u201c\u4f5c\u5047\u201d\u548c\u201c\u5047\u4f5c\u201d<\/span><\/p>\n

dGMP\u7684\u98ce\u9669–\u539f\u8f85\u6599\u7684\u7b26\u5408\u6027\uff08\u968f\u65f6\u51c6\u5907\u8fdb\u884c\u7684\u539f\u6599\u836f\u53d8\u66f4\u7533\u62a5\u4e0e\u4e0d\u80fd\u505c\u6b62\u7684\u8f85\u6599\u63a2\u7a76\u5de5\u4f5c\uff09<\/span><\/p>\n

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a\u5982\u4f55\u6839\u636e\u6700\u65b0\u653f\u7b56\u8c03\u6574\u6ce8\u518c\u5de5\u4f5c<\/span><\/p>\n

b\u6ce8\u518c\u5de5\u4f5c\u5982\u4f55\u53ca\u65f6\u8ddf\u8e2a\u7814\u53d1\u8fdb\u5c55<\/span><\/p>\n

c\u5982\u4f55\u5b9e\u65f6\u8ddf\u8e2a\u8fdb\u5ea6\uff0c\u4ee5\u53ca\u57fa\u4e8e\u53d8\u66f4\u7ea0\u504f\u7ea0\u9519<\/span><\/p>\n

\u4e3b\u8bb2\u4eba\uff1a\u5218\u8001\u5e08<\/span>  <\/span><\/strong>\u56fd\u5bb6\u5c40\u9ad8\u7814\u9662\u5ba2\u5ea7\u8bb2\u5e08<\/span><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u4e00\u3001\u4f1a\u8bae\u65f6\u95f4\u5730\u70b9\uff1a<\/span><\/span><\/strong> <\/span><\/p>\n

\u65f6\u95f4\uff1a<\/span>2018\u5e741<\/span>1<\/span>\u6708<\/span><\/span>30<\/span>–<\/span>12\u67082<\/span>\u65e5<\/span>   (<\/span>30<\/span>\u65e5\u5168\u5929\u62a5\u5230<\/span>)<\/span><\/p>\n

\u5730\u70b9<\/span>: <\/span>\u5357\u4eac<\/span><\/span>\u5e02<\/span> \uff08\u5730\u70b9\u786e\u5b9a\u76f4\u63a5\u901a\u77e5\u62a5\u540d\u8005\uff09<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e8c\u3001\u53c2\u4f1a\u5bf9\u8c61<\/span><\/strong><\/span><\/p>\n

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\u4e09\u3001\u4f1a\u8bae\u8d39\u7528<\/span><\/strong><\/span><\/p>\n

\u4f1a\u8bae\u8d39\uff1a<\/span>2200\u5143<\/span>\/<\/span>\u4eba\u3002\u4f1a\u8bae\u8d39\u5305\u62ec\uff1a\u4f1a\u8bae\u3001\u7814\u8ba8\u3001\u8d44\u6599\u53ca\u8bba\u6587\u96c6\u3002\u98df\u5bbf\u7edf\u4e00\u5b89\u6392\uff0c\u8d39\u7528\u81ea\u7406\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u56db\u3001\u8054\u7cfb\u65b9\u5f0f<\/span> <\/span><\/span><\/strong><\/p>\n

\u8054<\/span> \u7cfb<\/span> \u4eba\uff1a\u6f58\u6613<\/span>      panyi2010@126.com   <\/span><\/span><\/strong><\/p>\n

  \u7535  \u8bdd\uff1a13522766753 \uff08\u5fae\u4fe1\u540c\u53f7\uff09<\/span><\/strong><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

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