{"id":5944,"date":"2018-06-12T01:00:00","date_gmt":"2018-07-27T08:47:48","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e3%80%90%e8%8d%af%e7%89%a9%e7%ae%80%e8%ae%af%e3%80%91%e5%ae%89%e7%bd%97%e6%9b%bf%e5%b0%bc%e6%ad%a3%e5%bc%8f%e4%b8%8a%e5%b8%82%e5%bd%93%e5%a4%a9%e5%8f%91%e8%b4%a7%e8%bf%87%e4%ba%bf%e5%85%83\/"},"modified":"2018-07-27T16:47:49","modified_gmt":"2018-07-27T08:47:49","slug":"%e3%80%90%e8%8d%af%e7%89%a9%e7%ae%80%e8%ae%af%e3%80%91%e5%ae%89%e7%bd%97%e6%9b%bf%e5%b0%bc%e6%ad%a3%e5%bc%8f%e4%b8%8a%e5%b8%82%e5%bd%93%e5%a4%a9%e5%8f%91%e8%b4%a7%e8%bf%87%e4%ba%bf%e5%85%83","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/5944\/","title":{"rendered":"\u3010\u836f\u7269\u7b80\u8baf\u3011\u5b89\u7f57\u66ff\u5c3c\u6b63\u5f0f\u4e0a\u5e02\u5f53\u5929\u53d1\u8d27\u8fc7\u4ebf\u5143"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p>&nbsp; &nbsp; <strong><span style=\"color: rgb(120, 172, 254);\">\u636e\u8def\u8fb9\u793e\u62a5\u9053\uff0c\u5b89\u7f57\u66ff\u5c3c\u6b63\u5f0f\u4e0a\u5e02\u5f53\u5929\u53d1\u8d27\u8fc7\u4ebf\u5143\u3002\u5728\u4eca\u5e745\u6708\u4efd\u4e09\u7ebf\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9002\u5e94\u75c7\u83b7\u6279\u3002<\/span><\/strong><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532681269.jpg\" alt=\"\u3010\u836f\u7269\u7b80\u8baf\u3011\u5b89\u7f57\u66ff\u5c3c\u6b63\u5f0f\u4e0a\u5e02\u5f53\u5929\u53d1\u8d27\u8fc7\u4ebf\u5143\" title=\"\u3010\u836f\u7269\u7b80\u8baf\u3011\u5b89\u7f57\u66ff\u5c3c\u6b63\u5f0f\u4e0a\u5e02\u5f53\u5929\u53d1\u8d27\u8fc7\u4ebf\u5143\"  \/><\/p>\n<p><br  \/><\/p>\n<h3 class=\"results-list__indication-heading show-tooltip\" style=\"font-size: 1.3rem;font-weight: bold;margin-top: 7px;margin-bottom: 5px;margin-left: 40px;display: inline-block;color: rgb(102, 102, 102);\"><span style=\"border-bottom: 1px dotted rgb(0, 0, 0);cursor: help;\">Active Indications (Highest Phase)<\/span><\/h3>\n<p><span style=\"color: rgb(102, 102, 102);\"><\/span><\/p>\n<p><br  \/><\/p>\n<ul class=\"data-list__content list-paddingleft-2\" style=\"list-style-type: none;\">\n<li>\n<p><span class=\"data-list__property-key\" style=\"margin-right: 10px;line-height: 19px;float: left;display: inline;width: 272.422px;text-align: right;\">Marketed&nbsp;<\/span><span class=\"data-list__property-value\" style=\"line-height: 19px;float: left;word-break: break-word;width: 654.859px;\">Non-small cell lung cancer<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"color: rgb(120, 172, 254);\"><span class=\"data-list__property-key\" style=\"margin-right: 10px;line-height: 19px;float: left;display: inline;width: 272.422px;text-align: right;\">Phase III&nbsp;<\/span><span class=\"data-list__property-value\" style=\"line-height: 19px;float: left;word-break: break-word;width: 654.859px;\">Alveolar soft part sarcoma; Colorectal cancer; Gastric cancer; Leiomyosarcoma; Synovial sarcoma; Thyroid cancer<\/span><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"color: rgb(120, 172, 254);\"><span class=\"data-list__property-key\" style=\"color: rgb(120, 172, 254);margin-right: 10px;line-height: 19px;float: left;display: inline;width: 272.422px;text-align: right;\">Phase II&nbsp;<\/span><span class=\"data-list__property-value\" style=\"color: rgb(120, 172, 254);line-height: 19px;float: left;word-break: break-word;width: 654.859px;\">Ewing&#8217;s sarcoma; Hepatocellular carcinoma; Neuroendocrine tumours; Oesophageal cancer; Renal cell carcinoma; Small cell lung cancer; Soft tissue sarcoma<\/span><\/span><span class=\"data-list__property-value\" style=\"line-height: 19px;float: left;word-break: break-word;width: 654.859px;\"><\/span><\/p>\n<\/li>\n<li>\n<p><span class=\"data-list__property-key\" style=\"margin-right: 10px;line-height: 19px;float: left;display: inline;width: 272.422px;text-align: right;\">Phase I\/II&nbsp;<\/span><span class=\"data-list__property-value\" style=\"line-height: 19px;float: left;word-break: break-word;width: 654.859px;\">Cervical cancer; Endometrial cancer; Fallopian tube cancer; Ovarian cancer; Peritoneal cancer<\/span><\/p>\n<\/li>\n<\/ul>\n<p><br  \/><\/p>\n<p><img class=\"\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532681269.jpeg\" alt=\"\u3010\u836f\u7269\u7b80\u8baf\u3011\u5b89\u7f57\u66ff\u5c3c\u6b63\u5f0f\u4e0a\u5e02\u5f53\u5929\u53d1\u8d27\u8fc7\u4ebf\u5143\" title=\"\u3010\u836f\u7269\u7b80\u8baf\u3011\u5b89\u7f57\u66ff\u5c3c\u6b63\u5f0f\u4e0a\u5e02\u5f53\u5929\u53d1\u8d27\u8fc7\u4ebf\u5143\"  \/><br  \/><\/p>\n<p>&nbsp; &nbsp; \u80ba\u764c\u662f\u5168\u7403\u548c\u4e2d\u56fd\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u6700\u9ad8\u7684\u6076\u6027\u80bf\u7624\u3002\u80ba\u764c\u60a3\u8005\u4e2d\u7ea6 85%\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002\u5927\u90e8\u5206\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u521d\u8bca\u65f6\u5df2\u4e3a\u665a\u671f\u3002\u5f53\u524d\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6cbb\u7597\u65b9\u6cd5\u4e3a\u4f9d\u636e\u4e34\u5e8a\u5206\u671f\u3001\u7ec4\u7ec7\u75c5\u7406\u5b66\u7c7b\u578b\u548c\u57fa\u56e0\u7a81\u53d8\u7b49\u56e0\u7d20\u7efc\u5408\u9009\u62e9\uff0c\u5176\u4e2d\u9776\u5411\u6cbb\u7597\u5df2\u7ecf\u6210\u4e3a\u6709\u7279\u5b9a\u57fa\u56e0\u7a81\u53d8\u7c7b\u578b\u60a3\u8005\u7684\u9996\u9009\u548c\u4e3b\u8981\u7684\u6cbb\u7597\u836f\u7269\uff0c\u6211\u56fd\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\uff0c\u5177\u6709\u9a71\u52a8\u57fa\u56e0\u7a81\u53d8\u7684\u60a3\u8005\u9ad8\u4e8e\u6b27\u7f8e\uff0c\u7ea6\u536030%\u5de6\u53f3\uff0c\u4f46\u5927\u90e8\u5206\uff0870%\uff09\u7684\u91ce\u751f\u578b\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4ecd\u9700\u63a5\u53d7\u4f20\u7edf\u5316\u7597\uff0c\u63a5\u53d7\u8fc7\u4e24\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u7684\u60a3\u8005\u5df2\u65e0\u6807\u51c6\u6cbb\u7597\uff0c\u4e9f\u5f85\u65b0\u836f\u7a81\u7834\u3002<br  \/><\/p>\n<p>&nbsp;&nbsp;&nbsp; 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\u7efc\u4e0a\uff0c\u9488\u5bf9\u63a5\u53d7\u8fc7\u4e24\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\/\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u672c\u54c1\u53ef\u4ee5\u964d\u4f4e\u75be\u75c5\u8fdb\u5c55\u4e0e\u6b7b\u4ea1\u98ce\u9669\uff0c\u5ef6\u957f\u603b\u751f\u5b58\u671f\uff0c\u5b89\u5168\u6027\u53ef\u63a5\u53d7\u3002\u73b0\u6709\u7814\u7a76\u6570\u636e\u652f\u6301\u672c\u54c1\u5728\u6211\u56fd\u6279\u51c6\u4e0a\u5e02\uff0c\u4ee5\u6ee1\u8db3\u4e24\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\/\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u8feb\u5207\u7684\u4e34\u5e8a\u9700\u6c42\u3002<\/p>\n<p><br  \/><\/p>\n<p>\u53c2\u8003\uff1a<\/p>\n<p>\u3000\u30101\u3011Binyan Lin, Xiuming Song, Dawei Yang, et al. Anlotinib inhibits angiogenesis via suppressing the activation of VEGFR2, PDGFR\u03b2 and FGFR1. Gene,654(2018), 77-86.<br  style=\"box-sizing: border-box;\"  \/><\/p>\n<p>\u3000\u30102\u3011Chengying Xie, Xiaozhe Wan, Haitian Quan, et al. Preclinical characterization of anlotinib, a highly potent and selective vascular endothelial growth factor receptor-2 inhibitor. Cancer Science, 2018:1-13.<\/p>\n<p>&nbsp; &nbsp; &nbsp; CDE\/CFDA\u3002<\/p>\n<\/p>\n<p><br  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u7269\u7b80\u8baf                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; \u636e\u8def\u8fb9\u793e\u62a5\u9053\uff0c\u5b89\u7f57\u66ff\u5c3c\u6b63\u5f0f\u4e0a\u5e02\u5f53\u5929\u53d1\u8d27\u8fc7\u4ebf\u5143\u3002\u5728\u4eca\u5e745\u6708\u4efd\u4e09\u7ebf\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9002\u5e94\u75c7\u83b7 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5945,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/5944"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=5944"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/5944\/revisions"}],"predecessor-version":[{"id":5948,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/5944\/revisions\/5948"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/5945"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=5944"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=5944"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=5944"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}