{"id":60137,"date":"2018-12-04T01:00:00","date_gmt":"2018-12-07T02:54:06","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/258a9ff0b4\/"},"modified":"2018-12-07T10:54:08","modified_gmt":"2018-12-07T02:54:08","slug":"258a9ff0b4","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/60137\/","title":{"rendered":"\u5357\u4eac\u4f20\u5947\u751f\u7269\u5728ASH\u4f1a\u8bae\u4e0a\u516c\u5e03CAR-T\u7ec6\u80de\u7597\u6cd5\u4e34\u5e8a\u6570\u636e"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/0-1544151247.png\" alt=\"\u5357\u4eac\u4f20\u5947\u751f\u7269\u5728ASH\u4f1a\u8bae\u4e0a\u516c\u5e03CAR-T\u7ec6\u80de\u7597\u6cd5\u4e34\u5e8a\u6570\u636e\" title=\"\u5357\u4eac\u4f20\u5947\u751f\u7269\u5728ASH\u4f1a\u8bae\u4e0a\u516c\u5e03CAR-T\u7ec6\u80de\u7597\u6cd5\u4e34\u5e8a\u6570\u636e\"><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/9-1544151247.jpg\" alt=\"\u5357\u4eac\u4f20\u5947\u751f\u7269\u5728ASH\u4f1a\u8bae\u4e0a\u516c\u5e03CAR-T\u7ec6\u80de\u7597\u6cd5\u4e34\u5e8a\u6570\u636e\" title=\"\u5357\u4eac\u4f20\u5947\u751f\u7269\u5728ASH\u4f1a\u8bae\u4e0a\u516c\u5e03CAR-T\u7ec6\u80de\u7597\u6cd5\u4e34\u5e8a\u6570\u636e\"><\/p>\n<p style=\"text-align: justify;\">LCAR-B38M \u662f\u4e00\u79cd\u9776\u5411BCMA\uff08\u6210\u719fB\u7ec6\u80de\u6297\u539f\uff09\u7684\u53cc\u7279\u5f02\u6027CAR-T\uff08\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff09\u7597\u6cd5\u3002LCAR-B38M\u6240\u7528\u7684\u4e0eBCMA\u53cc\u8868\u4f4d\u7ed3\u5408\u7684\u57fa\u56e2\u5177\u6709\u9ad8\u5ea6\u4eb2\u548c\u529b\uff0c\u5728\u7ed3\u6784\u4e0a\u4e0d\u540c\u4e8e\u5176\u4ed6\u9776\u5411BCMA\u7684CAR\u3002LCAR-B38M\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u7684\u4e34\u5e8a\u7814\u7a76\u7684\u521d\u6b65\u7ed3\u679c\u663e\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\u4ee5\u53ca\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff08Fan et al. JCO 2017; 35:18_suppl LBA3001\uff09\u3002\u4ee5\u4e0b\u662f\u6211\u4eec\u4e34\u5e8a\u8bd5\u9a8c\u5728\u5b89\u5168\u6027\u548c\u7597\u6548\u4e0a\u7684\u6700\u65b0\u6210\u679c\u3002<br  \/><\/p>\n<p style=\"text-align: justify;\">Legend-2\u7814\u7a76\uff08Clinical Trial\u7f16\u53f7NCT03090659\uff09\u662f\u4e00\u9879\u6b63\u5728\u8fdb\u884c\u4e2d\u7684\uff0c\u5355\u81c2\u5f00\u653e\u5f0f\u591a\u4e2d\u5fc3\u7684\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30LCAR-B38M\u5728\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\uff0818-80\u5c81\uff09\u4e2d\u7684\u7597\u6548\u3002\u5728\u6cbb\u7597\u5f00\u59cb\u524d5\u5929\u3001\u524d4\u5929\u548c\u524d3\u5929\uff0c\u5206\u522b\u7ed9\u60a3\u8005\u6ce8\u5c04300mg\/m2\u7684\u73af\u78f7\u9170\u80fa\u4ee5\u6e05\u9664\u5176\u6dcb\u5df4\u7ec6\u80de\u3002\u6e05\u9664\u6dcb\u5df4\u7ec6\u80de5\u5929\u540e\uff0c\u52063\u6b21\u7ed9\u60a3\u8005\u56de\u8f93LCAR-B38M CAR-T\u7ec6\u80de\uff08CAR\u9633\u6027\u7ec6\u80de \u5242\u91cf\u4e2d\u4f4d\u6570=0.5\u00d7106 cell\/kg\uff0c[\u8303\u56f4\uff1a0.07-2\u00d7106]\uff09\uff0c\u5242\u91cf\u5206\u522b\u4e3a\u603b\u8f93\u6ce8\u91cf\u768420%\uff0c30%\u548c50%\u3002<strong>\u7814\u7a76\u7684\u9996\u8981\u76ee\u6807\u662f\u8bc4\u4f30LCAR-B38M CAR-T\u7ec6\u80de\u7684\u5b89\u5168\u6027\uff1b\u6b21\u8981\u76ee\u6807\u662f\u8bc4\u4f30\u8be5\u7597\u6cd5\u5728\u9aa8\u9ad3\u7624\u6cbb\u7597\u4e2d\u7684\u7597\u6548\u3002<\/strong>\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u4f7f\u7528\u4e0d\u826f\u4e8b\u4ef6\u901a\u7528\u672f\u8bed\u6807\u51c6\uff08CTCAE\uff09v.4.03\u8fdb\u884c\u8bc4\u7ea7\uff0c\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u4ee5Lee\u5728Blood\u53d1\u8868\u7684\u6587\u732e\uff08Blood 2014; 124:188-95\uff09\u6240\u8ff0\u7684\u6807\u51c6\u8bc4\u4f30\u3002\u7597\u6548\u4ee5\u56fd\u9645\u9aa8\u9ad3\u7624\u5de5\u4f5c\u7ec4\uff08IMWG\uff09\u7684\u6807\u51c6\u8fdb\u884c\u8bc4\u4f30\u3002\u8be5\u5206\u6790\u6240\u7528\u6570\u636e\u5747\u6765\u81ea\u540c\u4e00\u5bb6\u4e34\u5e8a\u4e2d\u5fc3\u3002<\/p>\n<p style=\"text-align: justify;\">\u622a\u81f32018\u5e746\u670825\u65e5\uff0c57\u540d\u60a3\u8005\u63a5\u53d7\u4e86LCAR-B38M CAR-T\u7ec6\u80de\u56de\u8f93\u3002\u4e2d\u4f4d\u5e74\u9f84\u4e3a54\u5c81\uff08\u8303\u56f427-72\u5c81\uff09\uff0c\u8fd9\u4e9b\u60a3\u8005\u6b64\u524d\u63a5\u53d7\u8fc7\u7684\u6cbb\u7597\u7684\u4e2d\u4f4d\u7ebf\u6570\u4e3a3\uff08\u8303\u56f41-9\uff09\uff0c74%\u7684\u60a3\u8005\u5165\u7ec4\u65f6\u4e3aDurie-Salmon\u5206\u671f\u2162\u671f\u3002\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a12\u4e2a\u6708\uff08\u8303\u56f4\uff1a0.7-25\u4e2a\u6708\uff09\u3002<\/p>\n<p style=\"text-align: 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style=\"text-align: justify;\"><span style=\"color: rgb(0, 82, 255);\"><em>\u603b\u7f13\u89e3\u7387\uff08\u90e8\u5206\u7f13\u89e3\u7387PR\u6216\u66f4\u597d\u6548\u679c\uff09\u4e3a88%\uff0895%\u7f6e\u4fe1\u533a\u95f4[CI]\uff0c76-95\uff09\u300242\u540d\u60a3\u8005\u8fbe\u5230\u4e86\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\uff0874%\uff1b95%\u7f6e\u4fe1\u533a\u95f4\uff0c60-85\uff09\uff0c2\u540d\u60a3\u8005\u8fbe\u5230\u4e86\u5f88\u597d\u7684\u90e8\u5206\u7f13\u89e3\uff08VGPR\uff09\uff084%\uff1b95%\u7f6e\u4fe1\u533a\u95f4\uff0c0.4-12\uff09\uff0c6\u540d\u60a3\u8005\u8fbe\u5230\u4e86\u90e8\u5206\u7f13\u89e3\uff0811%\uff1b95%\u7f6e\u4fe1\u533a\u95f4\uff0c4-22\uff1b\u56fe1B\uff09\u3002<\/em><\/span>\u6d41\u5f0f\u7ec6\u80de\u68c0\u6d4b\u663e\u793a\uff0c42\u540d\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u7684\u60a3\u8005\u4e2d\uff0c 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style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/6-1544151248.jpg\" alt=\"\u5357\u4eac\u4f20\u5947\u751f\u7269\u5728ASH\u4f1a\u8bae\u4e0a\u516c\u5e03CAR-T\u7ec6\u80de\u7597\u6cd5\u4e34\u5e8a\u6570\u636e\" title=\"\u5357\u4eac\u4f20\u5947\u751f\u7269\u5728ASH\u4f1a\u8bae\u4e0a\u516c\u5e03CAR-T\u7ec6\u80de\u7597\u6cd5\u4e34\u5e8a\u6570\u636e\"><\/p>\n<p style=\"text-align: center;\">\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>LCAR-B38M \u662f\u4e00\u79cd\u9776\u5411BCMA\uff08\u6210\u719fB\u7ec6\u80de\u6297\u539f\uff09\u7684\u53cc\u7279\u5f02\u6027CAR-T\uff08\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff09\u7597\u6cd5\u3002LCA 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