{"id":6031,"date":"2018-06-11T01:00:00","date_gmt":"2018-07-27T09:11:09","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e6%af%8f%e5%91%a8%e8%8d%af%e8%ae%af-2018%e5%b9%b4%e7%ac%ac21%e6%9c%9f\/"},"modified":"2018-07-27T17:11:11","modified_gmt":"2018-07-27T09:11:11","slug":"%e6%af%8f%e5%91%a8%e8%8d%af%e8%ae%af-2018%e5%b9%b4%e7%ac%ac21%e6%9c%9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/6031\/","title":{"rendered":"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c21\u671f"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img class=\"\"           style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532682670-1.jpeg\" alt=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c21\u671f\" title=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c21\u671f\"  \/><\/p>\n<section class=\"_editor\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: 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SimSun;\">7\u3001\u5b89\u8fdb\u8fd1\u65e5\u57282018\u5e74ASCO\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u9776\u5411\u836f\u7269Kyprolis\uff08carfilzomib\uff0c\u5361\u975e\u4f50\u7c73\uff09\u2162\u671f\u4e34\u5e8a\u7814\u7a76ARROW\uff08NCT02412878\uff09\u7684\u6570\u636e\u3002Kyprolis\u4e34\u5e8a\u9879\u76ee\u7ee7\u7eed\u4e13\u6ce8\u4e8e\u5728\u6cbb\u7597\u9891\u7e41\u590d\u53d1\u548c\u96be\u4ee5\u6cbb\u7597\u7684MM\u65b9\u9762\u4e3a\u60a3\u8005\u53ca\u533b\u751f\u63d0\u4f9b\u66f4\u597d\u7684\u89e3\u51b3\u65b9\u6848\u3002\u7279\u522b\u662f\uff0cARROW\u7814\u7a76\u662f\u6bd4\u8f832\u79cd\u4e0d\u540c\u7684Kyprolis\u7ed9\u836f\u65b9\u6848\u7684\u9996\u4e2a\u4e5f\u662f\u552f\u4e00\u4e00\u4e2a\u968f\u673a\u2162\u671f\u7814\u7a76\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">8\u3001\u963f\u65af\u5229\u5eb7\u8fd1\u65e5\u5728\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u5ea6\u4f1a\u8bae\uff08ASCO2018\uff09\u4e0a\u516c\u5e03\u4e86\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09moxetumomab pasudotox\u6cbb\u7597\u6bdb\u7ec6\u80de\u767d\u7ec6\u80de\uff08HCL\uff09\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff08Study 1053\uff09\u7684\u6570\u636e\u3002moxetumomab pasudotox\u6cbb\u7597\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08OR\uff09\u4e3a75%\uff0c\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u4e3a41%\uff0c\u6301\u4e45\u7684CR\u7387\uff08\u4e3b\u8981\u7ec8\u70b9\uff09\u4e3a30%\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">9\u3001\u827e\u4f2f\u7ef4\u8fd1\u65e5\u516c\u5e03\u4e86\u65b0\u578b\u6297\u708e\u836fupadacitinib\uff08ABT-494\uff09\u2162\u671f\u4e34\u5e8a\u7814\u7a76SELECT-EARLY\u7684\u79ef\u6781\u9876\u7ebf\u6570\u636e\u3002\u6570\u636e\u663e\u793a\uff0c\u8be5\u7814\u7a76\u8fbe\u5230\u4e86\u5168\u90e8\u4e3b\u8981\u7ec8\u70b9\u548c\u6b21\u8981\u7ec8\u70b9\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">10\u3001Gilead Sciences\u65d7\u4e0b\u7684Kite\u516c\u53f8\u5728ASCO\u5e74\u4f1a\u4e0a\u53d1\u5e03\u4e86\u8be5\u516c\u53f8\u7684\u5728\u7814T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u7597\u6cd5\u6cbb\u7597HPV\u9633\u6027\u5b9e\u4f53\u7624\u7684\u4e34\u5e8a\u2160\u671f\u8bd5\u9a8c\u7684\u65e9\u671f\u6570\u636e\u3002\u8be5\u7814\u7a76\u8868\u660e\uff0c\u9776\u541116\u578bHPV(HPV-16)\u7684E7\u86cb\u767d\u7684TCR\u7597\u6cd5\u80fd\u591f\u5728\u90e8\u5206HPV-16\u9633\u6027\u764c\u75c7\u60a3\u8005\u8eab\u4e0a\u5b9e\u73b0\u80bf\u7624\u90e8\u5206\u7f13\u89e3\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">11\u3001\u793c\u6765\u516c\u53f8\u4e0eIncyte\u516c\u53f8\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u6279\u51c6\u4e86\u5176\u65b0\u836fOlumiant\uff08baricitinib\uff09\u4e0a\u5e02\uff0c\u6cbb\u7597\u7f79\u60a3\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff0c\u5374\u65e0\u6cd5\u4eceTNF\u6291\u5236\u5242\u6cbb\u7597\u4e2d\u53d7\u76ca\u7684\u6210\u4eba\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">12\u3001\u521b\u65b0\u578b\u751f\u7269\u533b\u836f\u516c\u53f8Kitov Pharma\u5ba3\u5e03\u7f8e\u56fdFDA\u6279\u51c6\u5176\u65d7\u8230\u7ec4\u5408\u836f\u7269Consensi\uff08\u6c28\u6c2f\u5730\u5e73[amlodipine]\u548c\u585e\u6765\u6614\u5e03[celecoxib]\uff09\u53e3\u670d\u7247\u5242\u4e0a\u5e02\uff0c\u6cbb\u7597\u9aa8\u5173\u8282\u708e\u75bc\u75db\u548c\u9ad8\u8840\u538b\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">13\u3001\u536b\u6750\u516c\u53f8\u5ba3\u5e03FDA\u5df2\u63a5\u53d7\u5ba1\u67e5\u65d7\u4e0b\u6297\u766b\u75eb\u836f\u7269Fycompa\uff08perampanel\uff09\u7684\u8865\u5145\u65b0\u836f\u7533\u8bf7\uff08sNDA\uff09\u3002\u672c\u6b21\u7533\u8bf7\u5bfb\u6c42\u4e3a\u8be5\u836f\u7269\u65b0\u589e\u513f\u79d1\u9002\u5e94\u75c7\uff0c\u4ee5\u6db5\u76d6\u90e8\u5206\u53d1\u4f5c\u6027\u766b\u75eb\u53d1\u4f5c\u548c\u539f\u53d1\u6027\u5168\u8eab\u6027\u5f3a\u76f4\u9635\u631b\u6027\u53d1\u4f5c\uff08PGTC\uff09\u53ca\u766b\u75eb\u53d1\u4f5c\u7684\u513f\u79d1\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">14\u3001\u7b2c\u4e00\u4e09\u5171\u682a\u5f0f\u4f1a\u793e\uff08Daiichi Sankyo\uff09\u5ba3\u5e03\u4e86\u5176\u9776\u5411HER2\u7684\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09DS-8201\uff0c\u5728241\u4f4d\u63a5\u53d7\u8fc7\u591a\u6b21\u6cbb\u7597\u7684HER2\u9633\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u7684\u957f\u671f1\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\uff0c\u7f13\u89e3\u7387\u8d8550%\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">15\u3001\u65b0\u57fa\u516c\u53f8\u4e0ebluebird bio\u57282018\u5e74ASCO\u5927\u4f1a\u4e0a\u5ba3\u5e03\u4e86\u5176CAR-T\u7597\u6cd5bb2121\u7684\u6700\u65b0\u6570\u636e\u3002\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u8fd9\u6b3eCAR-T\u7597\u6cd5\u4e3a\u665a\u671f\u590d\u53d1\u6027\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u5e26\u6765\u4e86\u6df1\u5ea6\u7684\u6301\u4e45\u7f13\u89e3\uff0c\u60a3\u8005\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u957f\u8fbe1\u5e74\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">16\u3001\u5b89\u8fdb\u516c\u53f8\u5728ASCO\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u5176\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8cA.R.R.O.W.\u7684\u6700\u65b0\u6570\u636e\u3002\u7814\u7a76\u8868\u660e\uff0c\u5176\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u65b0\u836fKYPROLIS\u00ae\uff08carfilzomib\uff09\u4e0e\u5730\u585e\u7c73\u677e\uff08dexamethasone\uff09\u7684\u7ec4\u5408\u7597\u6cd5\u6bcf\u5468\u4e00\u6b21\u7684\u6cbb\u7597\u65b9\u6848\u76f8\u8f83\u6bcf\u5468\u4e24\u6b21\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u80fd\u663e\u8457\u5ef6\u957f\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u63d0\u9ad8\u603b\u4f53\u7f13\u89e3\u7387\uff08ORR\uff09\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">17\u3001\u827e\u4f2f\u7ef4\u57282018\u5e74ASCO\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86\u4e00\u9879\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e2d\u671f\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u8868\u660e\u5176\u91cd\u78c5\u836f\u7269Imbruvica\uff08ibrutinib\uff09\u4e0eRituxan\uff08rituximab\uff09\u8054\u5408\u4f7f\u7528\uff0c\u53ef\u4ee5\u663e\u8457\u5ef6\u957f\u590d\u53d1\/\u96be\u6cbb\u6027\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08Waldenstr\u00f6m&#8217;s macroglobulinemia\uff0cWM\uff09\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u8fbe\u5230\u4e86\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">18\u3001Loxo Oncology\u57282018\u5e74ASCO\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u5176\u521b\u65b0\u7cbe\u51c6\u7597\u6cd5LOXO-292\u7684\u6700\u65b0\u4e34\u5e8a\u7ed3\u679c\u3002\u6570\u636e\u8868\u660e\uff0c\u5728\u5177\u6709\u7279\u5b9a\u9057\u4f20\u7279\u5f81\u7684\u764c\u75c7\u60a3\u8005\u4e2d\uff0c\u8fd9\u6b3e\u7597\u6cd5\u53d6\u5f97\u4e8677%\u7684\u603b\u4f53\u7f13\u89e3\u7387\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">19\u3001\u5728\u4e00\u9879\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u91cc\uff0c\u7f57\u6c0f\u7684\u5728\u7814\u65b0\u836ftaselisib\u8054\u5408\u5e38\u89c4\u7684\u6fc0\u7d20\u7597\u6cd5\uff0c\u80fd\u5ef6\u7f13\u665a\u671f\u4e73\u817a\u764c\u7684\u589e\u957f\uff0c\u5e76\u5c06\u764c\u75c7\u6076\u5316\u98ce\u9669\u51cf\u5c1130%\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">20\u3001\u9ed8\u6c99\u4e1c\u57282018\u5e74ASCO\u5e74\u4f1a\u4e0a\u8fde\u7eed\u516c\u5e03\u4e86\u591a\u9879\u5173\u4e8eKeytruda\u7684\u79ef\u6781\u6210\u679c\u3002\u7b2c\u4e00\u9879\u7814\u7a76KEYNOTE-042\u662f\u56fd\u9645\u3001\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u76843\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30Keytruda\u5355\u836f\u4e0e\u94c2\u7c7b\u5316\u7597\uff08\u5361\u94c2\u52a0\u7d2b\u6749\u9187\u6216\u5361\u94c2\u52a0\u57f9\u7f8e\u66f2\u585e\uff09\u76f8\u6bd4\uff0c\u4e00\u7ebf\u6cbb\u7597PD-L1\u9633\u6027\uff08TPS\u22651\uff05\uff09\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u7597\u6548\u3002\u7b2c\u4e8c\u9879\u7814\u7a76KEYNOTE-407\u8bc4\u4f30\u4e86Keytruda\u8054\u5408\u5361\u94c2\u7d2b\u6749\u9187\u6216\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\uff0c\u4e00\u7ebf\u6cbb\u7597\u8f6c\u79fb\u6027\u9cde\u72b6NSCLC\u7684\u7597\u6548\u3002\u7b2c\u4e09\u9879\u7814\u7a76KEYNOTE-427\uff08\u961f\u5217A\uff09\u8bc4\u4f30\u4e86Keytruda\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u900f\u660e\u7ec6\u80de\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u7684\u7597\u6548\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><img loading=\"lazy\" class=\"\"     height=\"160\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" width=\"431\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress4-1532682670.jpeg\" alt=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c21\u671f\" title=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c21\u671f\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">21\u3001Seattle Genetics\u4e0e\u5b89\u65af\u6cf0\u6765\uff08Astellas\uff09\u5728ASCO\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u5176\u5728\u7814\u65b0\u836fenfortumab vedotin\u57281\u671f\u4e34\u5e8a\u4e2d\u7684\u6700\u65b0\u6570\u636e\u3002\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u6b3e\u521b\u65b0\u7597\u6cd5\u5728\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u6cbb\u7597\u4e2d\uff0c\u5c55\u73b0\u51fa\u4e86\u53ef\u559c\u7684\u6210\u679c\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">22\u3001\u8bfa\u534e\u516c\u53f8\u5728ASCO\u5e74\u4f1a\u4e0a\u516c\u5e03\uff0c\u5728HR\u9633\u6027\u3001HER2\u9634\u6027\u7684\u4e73\u817a\u764c\u60a3\u8005\u4e2d\uff0cKisqali\u8054\u5408fulvestrant\u53ef\u4ee5\u8fbe\u5230\u7684\u75c5\u60c5\u7a33\u5b9a\u671f\u6bd4\u5355\u72ec\u4f7f\u7528fulvestrant\u8981\u957f\u7ea68\u4e2a\u6708\u7684\u65f6\u95f4\u3002\u8bd5\u9a8c\u4e2d\u5305\u62ec\u4ee5\u524d\u6ca1\u6709\u63a5\u53d7\u8fc7\u6cbb\u7597\u548c\u63a5\u53d7\u8fc7\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u5987\u5973\u3002<\/span><\/p>\n<section class=\"_editor\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"max-width: 100%;display: inline-block;vertical-align: bottom;width: 2em;overflow: hidden !important;box-sizing: border-box;\"><img  style=\"vertical-align: middle;box-sizing: border-box;width: 100%;\" width=\"100%\"   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532682671.png\" alt=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c21\u671f\" title=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c21\u671f\"  \/><\/section>\n<section style=\"display: inline-block;vertical-align: middle;border-top: 1px dashed rgb(219, 193, 164);border-bottom: 1px dashed rgb(219, 193, 164);border-right-color: rgb(219, 193, 164);border-left-color: rgb(219, 193, 164);margin: 0.9em 2px 0.6em;padding-top: 2px;padding-bottom: 2px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u56fd\u5185\u836f\u7269\u7814\u53d1\u52a8\u6001<\/p>\n<\/section>\n<section style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 2em;overflow: hidden !important;box-sizing: border-box;\"><img  style=\"vertical-align: middle;box-sizing: border-box;width: 100%;\" title=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c21\u671f\" width=\"100%\"   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532682671.png\" alt=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c21\u671f\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">1\u3001\u79d1\u4f26\u836f\u4e1a\u8fde\u53d1\u4e24\u5219\u516c\u544a\u79f0\uff0c\u4e8e\u8fd1\u65e5\u83b7\u5f97\u4e86\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6838\u51c6\u7b7e\u53d1\u7684\u5511\u6765\u81a6\u9178\u6ce8\u5c04\u6db2\u548c\u76d0\u9178\u53f3\u7f8e\u6258\u54aa\u5b9a\u6ce8\u5c04\u6db2\u7684\u300a\u836f\u54c1\u6ce8\u518c\u6279\u4ef6\u300b\u3002<\/span><span style=\"font-family: \u5b8b\u4f53, SimSun;\"><\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">2\u3001\u524d\u6cbf\u751f\u7269\u836f\u4e1a\uff08\u5357\u4eac\uff09\u80a1\u4efd\u6709\u9650\u516c\u53f8\u8fd1\u65e5\u5ba3\u5e03\uff0c\u5176\u81ea\u4e3b\u7814\u53d1\u7684\u56fd\u5bb6\u4e00\u7c7b\u65b0\u836f\u827e\u53ef\u5b81\u00ae\uff08\u6ce8\u5c04\u7528\u827e\u535a\u97e6\u6cf0\uff09\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u4e0a\u5e02\u3002\u827e\u53ef\u5b81\u00ae\u662f\u5168\u7403\u7b2c\u4e00\u4e2a\u957f\u6548HIV-1\u878d\u5408\u6291\u5236\u5242\u3001\u4e2d\u56fd\u7b2c\u4e00\u4e2a\u539f\u521b\u6297\u827e\u65b0\u836f\uff0c\u7531\u524d\u6cbf\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u6210\u529f\uff0c\u62e5\u6709\u5168\u7403\u77e5\u8bc6\u4ea7\u6743\u3002<\/span><\/p>\n<p style=\"text-align: center;line-height: 2em;margin-bottom: 10px;\"><img loading=\"lazy\" class=\"\"     height=\"217\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" width=\"385\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1532682671.jpeg\" alt=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c21\u671f\" title=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c21\u671f\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">3\u30016\u67088\u65e5\uff0c\u6d59\u6c5f\u6d77\u6b63\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6838\u51c6\u7b7e\u53d1\u7684\u6ce8\u5c04\u7528\u76d0\u9178\u8868\u67d4\u6bd4\u661f\u7684\u300a\u836f\u54c1\u6ce8\u518c\u6279\u4ef6\u300b\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">4\u3001\u7279\u745e\u601d\u81ea\u4e3b\u7814\u53d1\u7684\u5355\u6297\u5076\u8054\u836f\u7269\u201c\u6ce8\u5c04\u7528TRS005\u201d\u5728\u65b0\u836f\u7279\u6b8a\u5ba1\u6279\u5236\u5ea6\u7684\u652f\u6301\u4e0b\uff0c\u987a\u5229\u83b7\u5f97\u4e34\u5e8a\u6279\u4ef6\uff0c\u5e76\u5df2\u542f\u52a8\u2160\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">5\u3001\u4e9a\u76db\u533b\u836f\u4ee5\u58c1\u62a5\u7684\u62a5\u544a\u65b9\u5f0f\u7cbe\u5f69\u4eae\u76f82018\u5e74ASCO\u4f1a\u573a\uff0c\u5c55\u793a\u4e86\u4e24\u9879\u5206\u522b\u9488\u5bf9BCL-2\/BCL-xL\u53cc\u9776\u70b9\u6291\u5236\u5242APG-1252\u3001\u65b0\u9776\u70b9IAP\u6291\u5236\u5242APG-1387\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u5f15\u53d1\u4e1a\u754c\u9ad8\u5ea6\u5173\u6ce8\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">6\u3001\u8fc8\u535a\u65af\u751f\u7269\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u5168\u7403\u9996\u4e2a\u5177\u6709pH\u4f9d\u8d56\u6027\u7684PD-L1\u6297\u4f53MSB2311\u5df2\u6b63\u5f0f\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u9881\u53d1\u7684\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\uff08\u6279\u4ef6\u53f72018L02471\uff09\u8fd9\u662f\u8fc8\u535a\u65af\u751f\u7269\u7ee7\u8be5\u4ea7\u54c1\u5728\u4eca\u5e742\u6708\u83b7\u5f97FDA\u4e34\u5e8a\u6279\u4ef6\u540e\u7684\u53c8\u4e00\u91cd\u5927\u8fdb\u5c55\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">7\u3001\u8fd1\u65e5\uff0c\u6d77\u5357\u53cc\u6210\u836f\u4e1a\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u516c\u53f82016\u5e7412\u670827\u65e5\u5411\u7f8e\u56fdFDA\u7533\u62a5\u7684\u6ce8\u5c04\u7528\u6bd4\u4f10\u82a6\u5b9a\u7684\u7b80\u5316\u65b0\u836f\u7533\u8bf7\uff08\u4ee5\u4e0b\u7b80\u79f0\u201cANDA\u201d\uff09\u5df2\u83b7\u5f97\u6682\u5b9a\u6279\u51c6\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, 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style=\"vertical-align: middle;box-sizing: border-box;width: 100%;\" title=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c21\u671f\" width=\"100%\"   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress7-1532682671.png\" alt=\"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c21\u671f\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">1\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u751f\u7269\u4e0e\u5316\u5b66\u4ea4\u53c9\u7814\u7a76\u4e2d\u5fc3\uff08\u4f9d\u6258\u4e2d\u79d1\u9662\u4e0a\u6d77\u6709\u673a\u5316\u5b66\u7814\u7a76\u6240\u7b49\u5355\u4f4d\uff09\u5218\u806a\u8bfe\u9898\u7ec4\u8fd1\u5e74\u6765\u4e00\u76f4\u81f4\u529b\u4e8e\u7814\u7a76\u81f4\u75c5\u4ee5\u53ca\u529f\u80fd\u6027\u86cb\u767d\u8d28\u7684\u6dc0\u7c89\u6837\u805a\u96c6(amyloid)\u7684\u539f\u5b50\u7ed3\u6784\u4ee5\u53ca\u57fa\u4e8e\u6dc0\u7c89\u6837\u86cb\u767d\u539f\u5b50\u7ed3\u6784\u7684\u751f\u7269\u7eb3\u7c73\u6750\u6599\u8bbe\u8ba1\u3002\u8fd1\u671f\u8be5\u8bfe\u9898\u7ec4\u4e0e\u6e05\u534e\u5927\u5b66\u674e\u96ea\u660e\u4ee5\u53ca\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u674e\u4e39\u8bfe\u9898\u7ec4\u5408\u4f5c\uff0c\u53d1\u73b0FUS\u86cb\u767d\uff08\u6e10\u52a8\u4eba\u75c7\u4e2d\u5173\u952e\u81f4\u75c5\u86cb\u767d\uff09\u7684amyloid\u5177\u6709\u9ad8\u5ea6\u53ef\u9006\u6027\u548c\u53ef\u8c03\u63a7\u6027\uff08\u5305\u62ec\u78f7\u9178\u5316\u4ee5\u53ca\u6e29\u5ea6\u8c03\u63a7\uff09\uff0c\u8868\u5f81\u4e86FUS\u86cb\u767damyloid\u7684\u539f\u5b50\u7ed3\u6784\uff0c\u8bc1\u5b9e\u9ad8\u5ea6\u53ef\u9006\u7684amyloid\u5728FUS\u86cb\u767d\u7684\u6db2\u6001\u76f8\u5206\u79bb\u4e2d\u8d77\u5230\u91cd\u8981\u7684\u4f5c\u7528\u3002\u76f8\u5173\u5de5\u4f5c\u53d1\u8868\u5728\u300a\u81ea\u7136-\u7ed3\u6784\u4e0e\u5206\u5b50\u751f\u7269\u5b66\u300b\u4e0a\uff08Nature Structural &amp; Molecular Biology\uff0c2018, 25, 341-346\uff09\u3002<\/span><span style=\"font-family: \u5b8b\u4f53, SimSun;\"><\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">2\u3001\u300aNew England Journal of Medicine\u300b\u671f\u520a\u53d1\u8868\u4e86\u4e00\u9879\u5177\u6709\u91cc\u7a0b\u7891\u610f\u4e49\u7684\u7814\u7a76\uff0c\u8ba9\u5927\u5bb6\u91cd\u65b0\u601d\u8003\u201c\u764c\u75c7\u60a3\u8005\u662f\u5426\u9700\u8981\u63a5\u53d7\u5316\u7597\u201d\u8fd9\u4e00\u9009\u62e9\u9898\u3002\u6570\u636e\u663e\u793a\uff0c\u57fa\u4e8e\u80bf\u7624\u57fa\u56e0\u6d4b\u5e8f\uff0c\u5927\u591a\u6570\u6700\u5e38\u89c1\u7684\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\u53ef\u4ee5\u4e0d\u9700\u8981\u5316\u7597\u8fc7\u7a0b\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, 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Communications\u300b\u3002\u8be5\u7814\u7a76\u7531\u675c\u514b\u5927\u5b66\u8bb2\u5e2d\u6559\u6388\u3001\u6cdb\u751f\u5b50\u8054\u5408\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u79d1\u5b66\u5bb6\u960e\u6d77\u6559\u6388\u4e3b\u5bfc\uff0c\u675c\u514b\u5927\u5b66\u53ca\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\u7814\u7a76\u4eba\u5458\u8054\u540c\u6cdb\u751f\u5b50\u79d1\u5b66\u5bb6\u56e2\u961f\u5171\u540c\u5b8c\u6210\u3002\u7814\u7a76\u9996\u6b21\u53d1\u73b0\u4e86\u4e24\u79cd\u65b0\u7684\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u5206\u5b50\u5206\u578b\uff0c\u4ece\u800c\u5b8c\u6210\u4e86TERTpWT-IDHWT\uff08TERT\u542f\u52a8\u5b50\u91ce\u751f\u578b-IDH\u91ce\u751f\u578b\uff09\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u57fa\u56e0\u56fe\u8c31\u7684\u7ed8\u5236\u3002\u8be5\u7a81\u7834\u6027\u53d1\u73b0\u6709\u671b\u5f00\u53d1\u9488\u5bf9\u81f4\u6b7b\u6027\u8111\u80bf\u7624\u7684\u9776\u5411\u7597\u6cd5\uff0c\u4ee4\u66f4\u591a\u60a3\u8005\u53d7\u76ca\u3002<\/span><\/p>\n<p style=\"text-align: center;line-height: 2em;margin-bottom: 10px;\">\n<p style=\"text-align: justify;line-height: 2em;margin-bottom: 10px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\">4\u3001\u636e\u56fd\u5916\u533b\u7597\u5b66\u672f\u7f51\u7ad9medicalxpress\u62a5\u9053\uff0c\u6765\u81ea\u6885\u5965\u8bca\u6240\uff08Mayo Clinic\uff09\u548cExact Sciences Corporation\u7684\u7814\u7a76\u4eba\u5458\u4e00\u8d77\u5b8c\u6210\u4e86\u4e00\u9879\u2161\u671f\u7814\u7a76\uff0c\u8fd9\u9879\u7814\u7a76\u662f\u5c06\u4e00\u7ec4DNA\u6807\u8bb0\u7269\u4e0e\u7532\u80ce\u86cb\u767d\u4f5c\u4e3a\u68c0\u6d4b\u809d\u764c\u7684\u65b9\u6cd5\u8fdb\u884c\u6bd4\u8f83\u3002\u7814\u7a76\u4eba\u5458\u5728\u534e\u76db\u987f\u7279\u533a\u4e3e\u884c\u76842018\u5e74\u6d88\u5316\u75be\u75c5\u5468\u4f1a\u8bae\u4e0a\u5c55\u793a\u4e86\u4ed6\u4eec\u7684\u53d1\u73b0\uff0c\u6885\u5965\u8bca\u6240\u548cExact Sciences Corporation\u8868\u793a\uff0c\u4ed6\u4eec\u5df2\u7ecf\u5f00\u53d1\u51fa\u4e00\u79cdDNA\u8840\u6db2\u6d4b\u8bd5\uff0c\u80fd\u591f\u6b63\u786e\u8bc6\u522b95%\u7684\u5e38\u89c1\u809d\u764c\u75c5\u4f8b\u3002<\/span><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u521b\u836f\u7f51                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u56fd\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001 1\u3001FDA\u6279\u51c6Mylan\u516c\u53f8Fulphila (pegfilgrastim-jmdb)\u4e0a\u5e02\uff0c 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