{"id":60479,"date":"2018-11-13T01:00:00","date_gmt":"2018-12-07T02:57:09","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/6cc35ea858\/"},"modified":"2018-12-07T10:57:10","modified_gmt":"2018-12-07T02:57:10","slug":"6cc35ea858","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/60479\/","title":{"rendered":"\u7206\u6b3e\uff1a\u9ed8\u514bPD-L1\/TGF-\u03b2\u53cc\u6297\u706b\u901f\u8fdb\u5165\u4e2d\u56fd"},"content":{"rendered":"
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1.2018\u5e7411\u670812\u65e5\uff0c\u83b7\u5f97\u6211\u56fdCDE\u53d7\u7406\u516c\u793a\uff1a<\/span><\/strong><\/p>\n


<\/span><\/strong><\/p>\n

Merck \u81ea\u4e3b\u5f00\u53d1\u7684\u53cc\u6297M7824 (MSB0011359C)<\/span><\/strong><\/h1>\n


<\/span><\/strong><\/p>\n

\"\u7206\u6b3e\uff1a\u9ed8\u514bPD-L1\/TGF-\u03b2\u53cc\u6297\u706b\u901f\u8fdb\u5165\u4e2d\u56fd\"<\/p>\n


<\/p>\n

\u672c\u54c1\u4e3a\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u7684 PD-L1 \/TGF\u03b2 \u6297\u4f53\u878d\u5408\u86cb\u767d\u836f\u7269\u3002M7824\u4e00\u7aef\u8bc6\u522b\u7ed3\u5408PD-L1\u7684\u6297\u4f53\uff0c\u53e6\u4e00\u7aef\u7528\u4e8etrap TGF-\u03b2\u7684\u53d7\u4f53\uff0c\u540c\u65f6\u963b\u65ad\u76f8\u4e92\u72ec\u7acb\u53c8\u5f7c\u6b64\u4e92\u8865\u7684PD-L1\u901a\u8def\u548cTGF-\u03b2\u901a\u8def\u80fd\u591f\u4fc3\u8fdb\u514d\u75ab\u7ec6\u80de\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u3002<\/span><\/strong><\/h1>\n


<\/p>\n

\"\u7206\u6b3e\uff1a\u9ed8\u514bPD-L1\/TGF-\u03b2\u53cc\u6297\u706b\u901f\u8fdb\u5165\u4e2d\u56fd\"<\/span><\/p>\n


<\/p>\n

CLIN CANCER RES\u66fe\u57282018\u5e743\u6708\u53d1\u8868\u4e86\u4e00\u7bc7\u6587\u7ae0\uff0c\u62a5\u9053\u4e86M7824\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u80bf\u7624\u7684\u521d\u6b65\u4e34\u5e8a\u7ed3\u679c\u3002<\/span><\/p>\n


<\/p>\n

\u57282018\u5e74\u7684ASCO\u4e0aMerck\u4e5f\u5c55\u793a\u4e86\u672c\u6b3e\u836f\u7269\u3002\u9488\u5bf9\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff0c\u5728PD-L1\u9633\u6027\u60a3\u8005\u7fa4\u4f53\uff08PD-L1\u4e0d\u5c0f\u4e8e1%\uff09\uff0cM7824 (MSB0011359C)\u7684ORR\u8fbe40.7%\u3002\u5728PD-L1\u9ad8\u8868\u8fbe\u7684\u60a3\u8005\u7fa4\u4f53\uff08PD-L1\u4e0d\u5c0f\u4e8e80%\uff09\u4e2d\uff0cM7824\u7684ORR\u8fbe71.4%\u3002\u6570\u636e\u76f8\u5bf9\u5f88\u60ca\u8273\u4e86\u3002<\/span><\/h1>\n

2.\u56fd\u5185\u6052\u745e\u533b\u836f\u8dd1\u7684\u6700\u5feb\uff1aSHR-1701\u6ce8\u5c04\u6db2<\/span><\/strong><\/p>\n

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\"\u7206\u6b3e\uff1a\u9ed8\u514bPD-L1\/TGF-\u03b2\u53cc\u6297\u706b\u901f\u8fdb\u5165\u4e2d\u56fd\"<\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u6052\u745e\u533b\u836f\u57282018\u5e747\u670812\u65e5\uff0c\u516c\u544a\u672c\u6b3e\u836f\u54c1\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6838\u51c6\u7b7e\u53d1\u7684\u300a\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\u300b\uff0c\u5e76\u5c06\u4e8e\u8fd1\u671f\u5f00\u5c55I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n


<\/p>\n

2018\u5e741\u670831\u65e5\uff0c\u9012\u4ea4\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7\u53d7\u7406\u3002\u4ece\u7533\u62a5\u5230\u83b7\u6279\u4e34\u5e8a\u4e0d\u8db36\u4e2a\u6708\u3002\u5728\u8be5\u4ea7\u54c1\u7814\u53d1\u9879\u76ee\u4e0a\u5df2\u6295\u5165\u7814\u53d1\u8d39\u7528\u7ea6\u4e3a1800\u4e07\u5143\u4eba\u6c11\u5e01\u3002<\/span><\/p>\n<\/section>\n<\/section>\n


<\/p>\n

\u4e34\u5e8a\u767b\u8bb0\uff1a\u9996\u6b21\u516c\u793a\u4fe1\u606f\u65e5\u671f\uff0c2018-10-09\u3002<\/span><\/strong><\/p>\n


<\/p>\n\n\n\n\n\n\n\n\n\n\n
\u767b\u8bb0\u53f7\uff1a<\/td>\nCTR20181823<\/td>\n<\/tr>\n
 \u9002\u5e94\u75c7\uff1a<\/td>\n\u665a\u671f\u6076\u6027\u5b9e\u4f53\u7624<\/td>\n<\/tr>\n
 \u8bd5\u9a8c\u901a\u4fd7\u9898\u76ee\uff1a<\/td>\nSHR-1701\u5728\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u7684 I \u671f\u4e34\u5e8a\u7814\u7a76<\/td>\n<\/tr>\n
 \u8bd5\u9a8c\u4e13\u4e1a\u9898\u76ee\uff1a<\/td>\n\u8bc4\u4f30SHR-1701\u5728\u665a\u671f\u6076\u6027\u5b9e\u4f53\u80bf\u7624\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7684I\u671f\u4e34\u5e8a\u7814\u7a76<\/td>\n<\/tr>\n
 \u8bd5\u9a8c\u65b9\u6848\u7f16\u53f7\uff1a<\/td>\nSHR-1701-I-101;1.0<\/td>\n<\/tr>\n
 \u4e34\u5e8a\u7533\u8bf7\u53d7\u7406\u53f7\uff1a<\/td>\n\u4f01\u4e1a\u9009\u62e9\u4e0d\u516c\u793a<\/td>\n<\/tr>\n
 \u836f\u7269\u540d\u79f0\uff1a<\/td>\nSHR-1701\u6ce8\u5c04\u6db2<\/td>\n<\/tr>\n
 \u836f\u7269\u7c7b\u578b\uff1a<\/td>\n\u751f\u7269\u5236\u54c1<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u53c2\u8003\uff1a<\/span><\/h1>\n

\u516c\u53f8\u516c\u5f00\u62ab\u9732;<\/span><\/h1>\n

NMPA\/CDE\uff1b<\/span><\/h1>\n

\u836f\u878d\u6570\u636e\uff0cPharnex  Datamonitor\uff1b<\/span><\/h1>\n

Julius Strauss,Christopher R.Heery,et al.Phase \u2160Trial of M7824(MSB0011359C),a Bifucntional Fusion Protein Targeting PD-L1 and TGF\u03b2,in Advanced Soli Tumor.CLIN CANCER RES.March 2018 doi:10.1158\/1078-0432.CCR-17-2653\uff1b<\/span><\/h1>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

1.2018\u5e7411\u670812\u65e5\uff0c\u83b7\u5f97\u6211\u56fdCDE\u53d7\u7406\u516c\u793a\uff1a Merck \u81ea\u4e3b\u5f00\u53d1\u7684\u53cc\u6297M7824 (MSB00113 […]<\/p>\n","protected":false},"author":1,"featured_media":60480,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60479"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=60479"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60479\/revisions"}],"predecessor-version":[{"id":60484,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60479\/revisions\/60484"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/60480"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=60479"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=60479"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=60479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}