{"id":60594,"date":"2018-10-26T01:00:00","date_gmt":"2018-12-07T02:58:35","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/dc4f9188fe\/"},"modified":"2018-12-07T10:58:37","modified_gmt":"2018-12-07T02:58:37","slug":"dc4f9188fe","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/60594\/","title":{"rendered":"\u7eff\u8c37\u5236\u836f\u53bb\u5e74\u9500\u552e\u4e1a\u7ee9\u7ea650\u4ebf ; \u963f\u5c14\u5179\u6d77\u9ed8\u65b0\u836f971\u6570\u636e\u62ab\u9732"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><strong>1.\u7eff\u8c37\u5236\u836f,<\/strong>1500\u591a\u540d\u5458\u5de5\uff0c\u5176\u5728\u4e2d\u56fd\u7684\u4e1a\u52a1\u904d\u53ca31\u4e2a\u7701\/\u5e02\uff0c<span style=\"color: rgb(216, 79, 169);\">\u4e0a\u4e00\u8d22\u5e74\u5b9e\u73b0\u8425\u65367\u4ebf\u591a\u7f8e\u5143<\/span>\u3002\u4e3b\u8981\u4ea7\u54c1\u4e39\u53c2\u591a\u915a\u9178\u76d0\u662f\u4e2d\u56fd\u5fc3\u8840\u7ba1\u75be\u75c5\u5355\u54c1\u9500\u552e\u524d10\u5f3a\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/7-1544151516.jpg\" alt=\"\u7eff\u8c37\u5236\u836f\u53bb\u5e74\u9500\u552e\u4e1a\u7ee9\u7ea650\u4ebf ; \u963f\u5c14\u5179\u6d77\u9ed8\u65b0\u836f971\u6570\u636e\u62ab\u9732\" title=\"\u7eff\u8c37\u5236\u836f\u53bb\u5e74\u9500\u552e\u4e1a\u7ee9\u7ea650\u4ebf ; \u963f\u5c14\u5179\u6d77\u9ed8\u65b0\u836f971\u6570\u636e\u62ab\u9732\"  \/><\/p>\n<p><span style=\"color: rgb(216, 79, 169);\">2017M5\u5728\u7b2c\u516b\u4f4d\uff0c2018M5\u5728\u7b2c\u5341\u4f4d\u3002<\/span><\/p>\n<p><span style=\"color: rgb(216, 79, 169);\"><br  \/><\/span><\/p>\n<p><img   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/1-1544151516.jpg\" alt=\"\u7eff\u8c37\u5236\u836f\u53bb\u5e74\u9500\u552e\u4e1a\u7ee9\u7ea650\u4ebf ; \u963f\u5c14\u5179\u6d77\u9ed8\u65b0\u836f971\u6570\u636e\u62ab\u9732\" title=\"\u7eff\u8c37\u5236\u836f\u53bb\u5e74\u9500\u552e\u4e1a\u7ee9\u7ea650\u4ebf ; \u963f\u5c14\u5179\u6d77\u9ed8\u65b0\u836f971\u6570\u636e\u62ab\u9732\"  \/><\/p>\n<p><strong><br  \/><\/strong><\/p>\n<p><strong>2.GV-971\u7684\u65b0\u836f\u6ce8\u518c\u548c\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\u6700\u8fd1\u5df2\u63d0\u4ea4\u7ed9NMPA\uff0c\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u3002<\/strong><span style=\"color: rgb(216, 79, 169);\">\u5e76\u8ba1\u5212\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u8fdb\u884c\u5168\u7403\u8bd5\u9a8c\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u8fd1\u65e5\uff0c\u7eff\u8c37\u5236\u836f\u5728\u897f\u73ed\u7259\u5df4\u585e\u7f57\u90a3\u4e3e\u884c\u7684\u7b2c11\u5c4a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e34\u5e8a\u8bd5\u9a8c\u5927\u4f1a(CTAD)\u4e0a\u5ba3\u5e03\u4e86\u591a\u9776\u70b9\u7cd6\u7c7b\u836f\u7269\u7518\u9732\u5be1\u7cd6\u4e8c\u9178(GV-971)\u5728\u4e2d\u56fd34\u4e2a\u5730\u70b9\u62db\u52df\u7684818\u540d\u60a3\u8005\u4e2d\u6cbb\u7597\u8f7b\u3001\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u91cd\u8981\u53d1\u73b0\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u5728\u8fd9\u9879\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u8bd5\u9a8c\u4e2d\uff0c818\u540d\u60a3\u8005\u88ab\u968f\u673a\u5206\u4e3a\u53e3\u670dGV-971\u836f\u7269450\u6beb\u514b\/\u6b21\uff0c\u6bcf\u65e5\u4e24\u6b21\uff0c\u6216\u5b89\u6170\u5242\u6cbb\u759736\u5468\u3002\u8bd5\u9a8c\u53c2\u4e0e\u8005\u5e74\u9f84\u572850-85\u5c81\u4e4b\u95f4\uff0c\u7b26\u5408\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4e34\u5e8a\u6807\u51c6\uff0cMMSE\u8bc4\u5206\u572811-26\u5206\u4e4b\u95f4\uff0c\u78c1\u5171\u632f\u663e\u793a\u5185\u4fa7\u989e\u53f6\u840e\u7f29\u89c6\u89c9\u8bc4\u5b9a\u91cf\u8868\u22652\u7ea7\u3001Fazekas\u8111\u767d\u8d28\u635f\u5bb3\u8bc4\u5b9a\u91cf\u8868&lt;3\u7ea7\u3001\u8111\u8154\u9699\u6027\u6897\u6b7b\u75c5\u7076\u4e0d\u8d85\u8fc72\u4e2a\u548c\u8111\u5173\u952e\u533a\u57df\u65e0\u8154\u9699\u6027\u6897\u6b7b\u75c5\u7076\u3002\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u662fADAS-Cog 12(\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8bc4\u5b9a\u91cf\u8868-\u8ba4\u77e5\u91cf\u8868)\u81ea\u57fa\u7ebf\u81f336\u5468\u7684\u53d8\u5316\uff0c\u6b21\u8981\u7597\u6548\u7ec8\u70b9\u5305\u62ecCIBIC plus, ADCS-ADL\u548cNPI\u81ea\u57fa\u7ebf\u81f336\u5468\u7684\u53d8\u5316\u3002\u5b89\u5168\u6027\u8bc4\u4f30\u5305\u62ecAE\u3001\u5b9e\u9a8c\u5ba4\u8bc4\u4f30\u3001\u751f\u547d\u4f53\u5f81\u3001\u5fc3\u7535\u56fe\u3001\u4f53\u683c\u68c0\u67e5\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 14px;\">GV-971\u5728\u4e3b\u8981\u7597\u6548\u7ec8\u70b9ADAS-Cog12\u65b9\u9762\u663e\u793a\u51fa\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u6539\u5584(<em>p<\/em>&lt;0.0001)\u3002GV-971\u4e0e\u5b89\u6170\u5242\u572836\u5468\u65f6ADAS-Cog12\u8bc4\u5206\u7684\u5e73\u5747\u5dee\u503c\u4e3a2.54\u3002GV-971\u4e0e\u5b89\u6170\u5242\u4e4b\u95f4\u7684\u8fd9\u4e00\u7edf\u8ba1\u5b66\u5dee\u5f02\u65e9\u5728\u7b2c4\u5468\u5c31\u88ab\u89c2\u5bdf\u5230\uff0c\u5e76\u5728\u6bcf\u6b21\u540e\u7eed\u8bc4\u4f30\u65f6\u6301\u7eed\u5b58\u5728\u3002\u836f\u7269\u5b89\u6170\u5242\u7684\u5dee\u5f02\u5728MMSE\u8bc4\u5206\u8303\u56f4\u5206\u522b\u4e3a11-14\u300115-19\u548c20-26\u5206\u7684\u4e09\u4e2a\u5b50\u7ec4\u4e2d\u4e5f\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u5728CIBIC-plus (P=0.059)\u65b9\u9762\u6ca1\u89c2\u5bdf\u5230\u663e\u8457\u7684\u6539\u5584\u8d8b\u52bf\u3002ADCS-ADL\u548cNPI\u65b9\u9762\u4e5f\u6ca1\u6709\u89c2\u5bdf\u5230\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u5dee\u5f02\u3002\u6bcf\u65e5\u4e24\u6b21\u53e3\u670d\u836f\u7269\u6cbb\u7597\u62e5\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u5b58\u5728\u4e0d\u826f\u6216\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u7684\u53c2\u4e0e\u8005\u767e\u5206\u6bd4\u6ca1\u6709\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u7ec4\u95f4\u5dee\u5f02\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><strong>3.\u7814\u7a76\u9886\u57df\uff1a<\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/10-1544151517.jpg\" alt=\"\u7eff\u8c37\u5236\u836f\u53bb\u5e74\u9500\u552e\u4e1a\u7ee9\u7ea650\u4ebf ; \u963f\u5c14\u5179\u6d77\u9ed8\u65b0\u836f971\u6570\u636e\u62ab\u9732\" title=\"\u7eff\u8c37\u5236\u836f\u53bb\u5e74\u9500\u552e\u4e1a\u7ee9\u7ea650\u4ebf ; \u963f\u5c14\u5179\u6d77\u9ed8\u65b0\u836f971\u6570\u636e\u62ab\u9732\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;letter-spacing: 0.483556px;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(51, 51, 51);font-size: 14px;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u53c2\u8003\uff1a<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;background: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;letter-spacing: 2px;color: rgb(89, 89, 89);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">NMPA\/CDE\uff1b<\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;background: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;letter-spacing: 2px;color: rgb(89, 89, 89);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u836f\u878d\u6570\u636e\uff0cPharnex &nbsp;Datamonitor\uff1b<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;background: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;letter-spacing: 2px;color: rgb(89, 89, 89);box-sizing: border-box !important;word-wrap: break-word !important;\">\u76f8\u5173\u516c\u53f8\u516c\u5f00\u62ab\u9732\u7b49\u3002<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>1.\u7eff\u8c37\u5236\u836f,1500\u591a\u540d\u5458\u5de5\uff0c\u5176\u5728\u4e2d\u56fd\u7684\u4e1a\u52a1\u904d\u53ca31\u4e2a\u7701\/\u5e02\uff0c\u4e0a\u4e00\u8d22\u5e74\u5b9e\u73b0\u8425\u65367\u4ebf\u591a\u7f8e\u5143\u3002\u4e3b\u8981\u4ea7\u54c1\u4e39\u53c2\u591a\u915a\u9178 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":60595,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60594"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=60594"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60594\/revisions"}],"predecessor-version":[{"id":60599,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60594\/revisions\/60599"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/60595"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=60594"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=60594"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=60594"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}