{"id":60856,"date":"2018-11-30T01:00:00","date_gmt":"2018-12-07T03:02:06","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/a035d70634\/"},"modified":"2018-12-07T11:02:08","modified_gmt":"2018-12-07T03:02:08","slug":"a035d70634","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/60856\/","title":{"rendered":"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c42\u671f\uff09"},"content":{"rendered":"
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\u56fd\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/section>\n<\/section>\n
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1. \u6b27\u76df\u59d4\u5458\u4f1a\uff08EC\uff09\u5df2\u6279\u51c6Oasmia\u516c\u53f8\u7684Apealea\uff08paclitaxel micellar\uff0c\u7d2b\u6749\u9187\u80f6\u675f\uff09\uff0c\u8054\u5408\u5361\u94c2\u7528\u4e8e\u9996\u6b21\u590d\u53d1\u7684\u94c2\u654f\u611f\u6027\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u539f\u53d1\u6027\u8179\u819c\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002\u6b64\u6b21\u6279\u51c6\u9002\u7528\u4e8e28\u4e2a\u6b27\u76df\u6210\u5458\u56fd\u53ca\u6b27\u6d32\u7ecf\u6d4e\u533a\u6210\u5458\u56fd\u51b0\u5c9b\u3001\u5217\u652f\u6566\u58eb\u767b\u548c\u632a\u5a01\u3002<\/span><\/p>\n

2. Northwest Biotherapeutics\u5728\u7f8e\u56fd\u65b0\u5965\u5c14\u826f\u4e3e\u884c\u76842018\u7f8e\u56fd\u795e\u7ecf\u80bf\u7624\u5b66\u4f1a\uff08SNO\uff09\u7b2c23\u5c4a\u5e74\u4f1a\u4e0a\uff0c\u516c\u5e03\u4e86\u5176\u5148\u5bfc\u7597\u6cd5DCVax\u00ae-L\uff08\u75ab\u82d7\uff09\u6cbb\u7597\u65b0\u8bca\u591a\u5f62\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff08GBM\uff09\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u66f4\u65b0\u8bbe\u76f2\u4e2d\u671f\u8bd5\u9a8c\u6570\u636e\u3002<\/span><\/p>\n

3. Loxo Oncology\u548c\u62dc\u8033\uff08Bayer\uff09\u516c\u53f8\u8054\u5408\u5ba3\u5e03\uff0cFDA\u52a0\u901f\u6279\u51c6\u53cc\u65b9\u5171\u540c\u5f00\u53d1\u7684Vitrakvi\uff08larotrectinib\uff09\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u643a\u5e26NTRK\u57fa\u56e0\u878d\u5408\u7684\u6210\u5e74\u548c\u513f\u7ae5\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\uff0c\u4e0d\u9700\u8003\u8651\u764c\u75c7\u7684\u53d1\u751f\u533a\u57df\u3002\u8fd9\u4e00\u836f\u7269\u7684\u6279\u51c6\uff0c\u662f\u764c\u75c7\u7597\u6cd5\u4ece\u201c\u57fa\u4e8e\u764c\u75c7\u5728\u4f53\u5185\u7684\u8d77\u6e90\u201d\u8f6c\u5411\u201c\u57fa\u4e8e\u80bf\u7624\u7684\u9057\u4f20\u7279\u5f81\u201d\u8fd9\u4e00\u6f14\u53d8\u8fc7\u7a0b\u4e2d\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c42\u671f\uff09\"<\/p>\n

4. RNAi\u7597\u6cd5\u5f00\u53d1\u9886\u57df\u7684\u9886\u519b\u4f01\u4e1aAlnylam\u4e0e\u7f8e\u56fd\u52a0\u5dde\u521d\u521b\u751f\u7269\u6280\u672f\u516c\u53f8Vir\u8fd1\u65e5\u8054\u5408\u5ba3\u5e03\u542f\u52a8\u4e00\u9879I\/II\u671f\u4e34\u5e8a\u7814\u7a76\uff08NCT03672188\uff09\uff0c\u8bc4\u4f30\u4e00\u79cd\u65b0\u7684\u5b9e\u9a8c\u6027RNAi\u836f\u7269VIR-2218\u6cbb\u7597\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u3002VIR-2218\u9996\u4e2a\u4eba\u4f53\u7ed9\u7a76\u7684\u542f\u52a8\uff0c\u4e5f\u6807\u5fd7\u7740Alnylam\u516c\u53f8ESC+GalNAc\u5171\u8f6d\u9012\u9001\u5e73\u53f0\u7684\u9996\u6b21\u4e34\u5e8a\u5e94\u7528\u3002<\/span><\/p>\n

5. ViiV Healthcare\u662f\u7531\u845b\u5170\u7d20\u53f2\u514b\uff08GSK\uff09\u3001\u8f89\u745e\uff08Pfizer\uff09\u3001\u76d0\u91ce\u4e49\uff08Shionogi\uff09\u5171\u540c\u6301\u80a1\u7684HIV\/AIDS\u836f\u7269\u7814\u53d1\u516c\u53f8\u3002\u8fd1\u65e5\uff0c\u8be5\u516c\u53f8\u5ba3\u5e03\u4e8c\u5408\u4e00HIV\u590d\u65b9\u65b0\u836fJuluca\uff08dolutegravir\/rilpivirine\uff0c\u591a\u66ff\u62c9\u97e6\/\u5229\u5339\u97e6\u6797\uff0c50mg\/25mg\u7247\u5242\uff09\u5df2\u83b7\u65e5\u672c\u536b\u751f\u52b3\u52a8\u798f\u5229\u90e8\uff08MHLW\uff09\u6279\u51c6\uff0c\u4f5c\u4e3a\u4e00\u79cd\u7ef4\u6301\u6cbb\u7597\u836f\u7269\uff0c\u7528\u4e8e\u5df2\u5b9e\u73b0\u75c5\u6bd2\u6291\u5236\u7684HIV-1\u6210\u4eba\u611f\u67d3\u8005\u7684\u957f\u671f\u6cbb\u7597\u3002<\/span><\/p>\n

6. Vertex Pharmaceuticals\u5ba3\u5e03\u5176\u5728\u7814\u4e0b\u4e00\u4ee3\u77eb\u6b63\u5242VX-659\uff0c\u4e0etezacaftor\u548civacaftor\u6784\u6210\u7684\u4e09\u8054\u7ec4\u5408\u7597\u6cd5\uff0c\u5728\u4e24\u9879\u6cbb\u7597\u56ca\u6027\u7ea4\u7ef4\u5316\uff08CF\uff09\u60a3\u8005\u76843\u671f\u8bd5\u9a8c\u4e2d\uff0c\u7686\u53d6\u5f97\u4e86\u79ef\u6781\u9876\u7ebf\u7ed3\u679c\u3002\u8be5\u4e09\u8054\u7ec4\u5408\u7597\u6cd5\u7edf\u8ba1\u663e\u8457\u5730\u6539\u5584\u4e86CF\u60a3\u8005\u7684\u80ba\u529f\u80fd\uff08\u68c0\u6d4b\u6807\u51c6\u4e3a\u4e00\u79d2\u7528\u529b\u547c\u6c14\u5bb9\u79ef\u5360\u9884\u8ba1\u503c\u7684\u767e\u5206\u6bd4\uff0cppFEV1\uff09\u3002<\/span><\/p>\n

7. \u5fb7\u56fd\u5236\u836f\u5de8\u5934\u62dc\u8033\uff08Bayer\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u6b27\u76df\u59d4\u5458\u4f1a\uff08EC\uff09\u5df2\u6279\u51c6Jivi\uff08BAY94-9027\uff09\uff0c\u7528\u4e8e\u65e2\u5f80\u5df2\u63a5\u53d7\u6cbb\u7597\u768412\u5c81\u53ca\u4ee5\u4e0a\u9752\u5c11\u5e74\u53ca\u6210\u4ebaA\u578b\u8840\u53cb\u75c5\u60a3\u8005\uff0c\u6cbb\u7597\u548c\u9884\u9632\u51fa\u8840\u3002Jivi\u63a8\u8350\u7684\u9884\u9632\u6027\u6cbb\u7597\u65b9\u6848\u4e3a\u6bcf5\u5929\u4e00\u6b21\uff0c\u6216\u6839\u636e\u60a3\u8005\u7684\u4e34\u5e8a\u7279\u5f81\uff0c\u4e5f\u53ef\u8c03\u6574\u4e3a\u6bcf7\u5929\u4e00\u6b21\u6216\u6bcf\u54682\u6b21\u3002<\/span><\/p>\n

8. \u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u7684\u514d\u75ab\u7ec4\u5408\u7597\u6cd5Opdivo+Yervoy\uff08\u7b80\u79f0\u201cOY\u201d\uff09\u57282018\u5e74\u6b27\u6d32\u80bf\u7624\u533b\u5b66\u534f\u4f1a\u4f1a\u8bae\uff08ESMO2018\uff09\u4e0a\u516c\u5e03\u7684\u6570\u636e\u663e\u793a\uff0cOY\u7ec4\u5408\u5728\u80be\u7ec6\u80de\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u8180\u80f1\u764c\u6cbb\u7597\u65b9\u9762\u5747\u8868\u73b0\u51fa\u663e\u8457\u7597\u6548\u3002\u8fd1\u65e5\uff0c\u8be5\u516c\u53f8\u516c\u5e03\u4e86OY\u7ec4\u5408\u6cbb\u7597\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\uff08ES-SCLC\uff09III\u671f\u4e34\u5e8a\u7814\u7a76\uff08CheckMate-451\uff09\u7684\u6570\u636e\u3002\u7136\u800c\uff0c\u8fd9\u4e00\u6b21\uff0cOY\u7ec4\u5408\u7684\u8868\u73b0\u5374\u975e\u5e38\u4ee4\u4eba\u5931\u671b\u3002<\/span><\/p>\n

8. \u7f57\u6c0f\u96c6\u56e2\u65d7\u4e0bGenentech\uff08\u57fa\u56e0\u6cf0\u514b\uff09\u5ba3\u5e03\u5bf9Jecure Therapeutics\u8fdb\u884c\u6536\u8d2d\u3002Jecure\u662f\u4e00\u5bb6\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u62e5\u6709\u9488\u5bf9\u4e25\u91cd\u708e\u75c7\u6027\u75be\u75c5\u7684\u65b0\u578b\u836f\u7269\u7684\u7814\u53d1\u8ba1\u5212\u3002\u901a\u8fc7\u6b64\u6b21\u6536\u8d2d\uff0c\u57fa\u56e0\u6cf0\u514b\u5c06\u83b7\u5f97Jecure\u516c\u53f8\u6574\u4e2aNLRP3\u6291\u5236\u5242\u4e34\u5e8a\u524d\u7ec4\u5408\u4ea7\u54c1\u7ebf\u7684\u5168\u90e8\u6743\u5229\u3002<\/span><\/p>\n

9. FDA\uff0c\u6279\u51c6\u5b89\u65af\u6cf0\u6765\uff08Astellas Pharma\uff09\u516c\u53f8\u7684Xospata\uff08gilteritinib\uff09\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u643a\u5e26FLT3\u57fa\u56e0\u7a81\u53d8\u7684\u590d\u53d1\/\u96be\u6cbb\u6027\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff08AML\uff09\u6210\u4eba\u60a3\u8005\uff08\u7ea6\u5360\u60a3\u8005\u603b\u6570\u7684\u4e09\u5206\u4e4b\u4e00\uff09\u3002\u8fd9\u4e9b\u60a3\u8005\u7684\u57fa\u56e0\u7a81\u53d8\u9700\u8981\u88abFDA\u6279\u51c6\u7684\u4f34\u968f\u8bca\u65ad\u786e\u8ba4\u3002<\/span><\/p>\n

10. \u65e5\u672c\u836f\u4f01\u536b\u6750\uff08Eisai\uff09\u8fd1\u65e5\u5ba3\u5e03\u6297\u766b\u75eb\u836fFycompa\uff08perampanel\uff0c\u5421\u4ed1\u5e15\u5948\uff09\u7684\u4e00\u9879\u65e5\u672cIII\u671f\u4e34\u5e8a\u7814\u7a76\uff08Study 342\uff09\u8fbe\u5230\u4e86\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u3002\u57fa\u4e8e\u8be5\u7814\u7a76\u6570\u636e\uff0c\u536b\u6750\u8ba1\u5212\u57282018\u8d22\u5e74\u5411\u65e5\u672c\u76d1\u7ba1\u673a\u6784\u63d0\u4ea4Fycompa\u5355\u836f\u6cbb\u7597\u90e8\u5206\u53d1\u4f5c\u6027\u766b\u75eb\u7684\u7533\u8bf7\u6587\u4ef6\u3002<\/span><\/p>\n

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\u56fd\u5185\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/section>\n<\/section>\n
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1. \u793c\u6765\u4e2d\u56fd\u5ba3\u5e03\uff0c\u65b0\u578b\u6cbb\u7597\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u9776\u5411\u836f\u7269\u7231\u4f18\u7279\u00ae\uff08\u544b\u55b9\u66ff\u5c3c\u80f6\u56ca\uff09\u6b63\u5f0f\u5728\u4e2d\u56fd\u4e0a\u5e02\u3002\u7231\u4f18\u7279\u00ae\uff08\u544b\u55b9\u66ff\u5c3c\u80f6\u56ca\uff09\u4e8e9\u67084\u65e5\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u7c7b\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u4e3a\u57fa\u7840\u7684\u5316\u7597\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u8fc7\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50 (VEGF\uff09\u6cbb\u7597\u3001\u6297\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53( EGFR\uff09\u6cbb\u7597 (RAS\u91ce\u751f\u578b\uff09\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c (mCRC\uff09\u60a3\u8005\u3002<\/span><\/p>\n

2. \u590d\u661f\u533b\u836f\u516c\u544a\u79f0\u5176\u63a7\u80a1\u5b50\u516c\u53f8\u590d\u5b8f\u6c49\u9716\u53ca\u6c49\u9716\u5236\u836f\u6536\u5230\u300a\u53d7\u7406\u901a\u77e5\u4e66\u300b\uff08\u53d7\u7406\u53f7\uff1aCXSL1800118\u56fd\uff09\uff0c\u5176\u7814\u5236\u7684HLX22 \u5355\u6297\u6ce8\u5c04\u6db2\u7528\u4e8e\u80c3\u764c\u548c\u4e73\u817a\u764c\u6cbb\u7597\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u5ba1\u8bc4\u53d7\u7406\u3002\u516c\u544a\u663e\u793a\uff0c\u5728\u5168\u7403\u8303\u56f4\u5185\u5c1a\u65e0\u4e0eHLX22\u5355\u6297\u6ce8\u5c04\u6db2\u540c\u7c7b\u4ea7\u54c1\u4e0a\u5e02\uff0c\u622a\u81f32018\u5e7410\u6708\uff0c\u590d\u661f\u533b\u836f\u73b0\u9636\u6bb5\u9488\u5bf9\u8be5\u836f\u5df2\u6295\u5165\u7814\u53d1\u8d39\u7528\u4e3a\u4eba\u6c11\u5e01\u7ea6 4520\u4e07\u5143\u3002<\/span><\/p>\n

3. \u6d77\u6b63\u836f\u4e1a\u516c\u544a\u79f0\uff0c\u5176\u63a7\u80a1\u5b50\u516c\u53f8\u6d77\u6b63\u836f\u4e1a\uff08\u676d\u5dde\uff09\u7684\u666e\u4f10\u4ed6\u6c40\u94a0\u7247\u7684\u65b0\u836f\u7b80\u7565\u7533\u8bf7\uff08ANDA\uff0c\u5373\u7f8e\u56fd\u4eff\u5236\u836f\u7533\u8bf7\u5df2\u83b7\u5f97\u6279\u51c6\u3002<\/span><\/p>\n

4. \u7ff0\u5b87\u836f\u4e1a\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u516c\u53f8\u63d0\u4ea4\u7684\u6ce8\u5c04\u7528\u918b\u9178\u897f\u66f2\u745e\u514b\uff08\u53d7\u7406\u53f7\uff1aCYHS1200781\uff09\u6ce8\u518c\u7533\u8bf7\u5728\u56fd\u5bb6\u836f\u76d1\u5c40\u7f51\u7ad9\u7684\u529e\u7406\u72b6\u6001\u53d8\u66f4\u4e3a\u201c\u5ba1\u6279\u5b8c\u6bd5-\u5f85\u5236\u8bc1\u201d\u3002\u7ff0\u5b87\u836f\u4e1a\u82e5\u80fd\u987a\u5229\u62ff\u5230\u6b63\u5f0f\u6279\u4ef6\uff0c\u5c06\u6210\u4e3a\u56fd\u5185\u9996\u4e2a\u83b7\u5f97\u6ce8\u5c04\u7528\u918b\u9178\u897f\u66f2\u745e\u6279\u51c6\u751f\u4ea7\u7684\u4f01\u4e1a\u3002<\/span><\/p>\n

5.\u6052\u745e\u533b\u836f\u65d7\u4e0b\u4e24\u6b3e\u5728\u7814\u65b0\u836fSHR0302\u7247\u548cSHR2285\u7247\u83b7\u6279\u4e34\u5e8a\uff0cSHR0302\u4e3a\u9ad8\u9009\u62e9\u6027\u7684JAK1\u6291\u5236\u5242\uff0cSHR2285\u7247\u7cfb\u6052\u745e\u533b\u836f2018\u5e74\u7533\u62a5\u4e34\u5e8a\u7684\u7b2c\u4e00\u4e2a1.1\u7c7b\u5316\u5b66\u65b0\u836f\uff0c\u6b64\u6b21\u83b7\u6279\u4e34\u5e8a\u7684\u9002\u5e94\u75c7\u52a8\u4e3a\u9759\u8109\u8840\u6813\u7684\u9884\u9632\u548c\u6cbb\u7597\uff0c\u964d\u4f4e\u4ecb\u5165\u6cbb\u7597\u6216\u4f53\u5916\u5faa\u73af\u5f15\u8d77\u7684\u8840\u6813\u6813\u585e\u98ce\u9669\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c42\u671f\uff09\"<\/p>\n

6. \u767e\u6d4e\u795e\u5dde\u4e0eZymeworks\u516c\u53f8\u5171\u540c\u5ba3\u5e03\uff0c\u53cc\u65b9\u5c31\u4e24\u6b3e\u5728\u7814HER2\u9776\u5411\u53cc\u7279\u5f02\u6027\u6297\u4f53\u836f\u7269ZW25\u548cZW49\u7684\u4e34\u5e8a\u5f00\u53d1\u548c\u63a8\u5e7f\u8fbe\u6210\u4e86\u6218\u7565\u5408\u4f5c\u3002\u767e\u6d4e\u795e\u5dde\u83b7\u5f97\u8fd9\u4e24\u6b3e\u5019\u9009\u836f\u7269\u5728\u4e9a\u6d32\uff08\u65e5\u672c\u9664\u5916\uff09\u3001\u6fb3\u5927\u5229\u4e9a\u548c\u65b0\u897f\u5170\u7684\u5f00\u53d1\u548c\u63a8\u5e7f\u7684\u72ec\u5bb6\u6388\u6743\u3002\u6b64\u5916\uff0c\u767e\u6d4e\u795e\u5dde\u8fd8\u83b7\u5f97\u6388\u6743\u53ef\u5229\u7528\u540e\u8005\u4e13\u5229\u4fdd\u62a4\u7684Azymetic\u2122\u548cEFECT\u2122\u5e73\u53f0\u9488\u5bf9\u81f3\u591a\u4e09\u79cd\u5176\u4ed6\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5728\u5168\u7403\u8303\u56f4\u5185\u8fdb\u884c\u7814\u53d1\u53ca\u63a8\u5e7f\u3002<\/span><\/p>\n

7. \u79d1\u4f26\u836f\u4e1a\u53d1\u5e03\u516c\u544a\u79f0\u5176\u7814\u53d1\u7684\u795e\u7ecf\u808c\u8089\u963b\u6ede\u5242\u62ee\u6297\u836f\u7269\u8212\u66f4\u8461\u7cd6\u94a0\u6ce8\u5c04\u6db2\u4e8e\u8fd1\u65e5\u5411\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u5e76\u83b7\u53d7\u7406\u3002\u8212\u66f4\u8461\u7cd6\u94a0\u6ce8\u5c04\u6db2\u662f\u5168\u7403\u9996\u4e2a\u7528\u4e8e\u9006\u8f6c\u795e\u7ecf\u808c\u8089\u963b\u6ede\u5242\u7684\u9009\u62e9\u6027\u677e\u5f1b\u62ee\u6297\u5242\uff0c\u9002\u7528\u4e8e\u62ee\u6297\u7f57\u5e93\u6eb4\u94f5\u6216\u7ef4\u5e93\u6eb4\u94f5\u8bf1\u5bfc\u7684\u795e\u7ecf\u808c\u8089\u963b\u6ede\u3002\u4e3a\u56fd\u5185\u9996\u5bb6\u7533\u62a5\u751f\u4ea7\u7684\u4f01\u4e1a\u3002<\/span><\/p>\n

8. \u8d35\u5dde\u767e\u7075\u4f01\u4e1a\u96c6\u56e2\u5236\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u516c\u53f8\u201d\uff092018\u5e7410\u67089\u65e5\u62ab\u9732\u4e86\u300a\u5173\u4e8e\u201c\u7532\u78fa\u9178\u666e\u4f9d\u53f8\u4ed6\u201d\u9879\u76ee\u65b0\u836f\u7533\u8bf7\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u53d7\u7406\u7684\u516c\u544a\u300b\uff08\u516c\u544a\u7f16\u53f7\uff1a2018-134\uff09\uff0c\u516c\u53f8\u4e0e\u56db\u5ddd\u5927\u5b66\u534e\u897f\u533b\u9662\u5171\u540c\u5f00\u53d1\u7684\u201c\u6cbb\u7597\u8840\u6db2\u7624\u5316\u836f1.1\u7c7b\u65b0\u836f\u7532\u78fa\u9178\u666e\u4f9d\u53f8\u4ed6\u201d\u9879\u76ee\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u7533\u8bf7\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u53d7\u7406\u3002\u8fd1\u65e5\uff0c\u8be5\u516c\u53f8\u79f0\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u4e0b\u53d1\u7684\u5173\u4e8e\u201c\u7532\u78fa\u9178\u666e\u4f9d\u53f8\u4ed6\u201d\u9879\u76ee\u7684\u300a\u4e34\u5e8a\u8bd5\u9a8c\u901a\u77e5\u4e66\u300b\u3002<\/span><\/p>\n

9. \u4f18\u65f6\u6bd4\u516c\u53f8\uff08UCB\uff09\u5f00\u53d1\u7684\u6297\u766b\u75eb\u836f\u7269\u300c\u62c9\u79d1\u9170\u80fa\u7247\u300d\u7684\u4e0a\u5e02\u7533\u8bf7\uff08JXHS1500077)\u7684\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6b63\u5f0f\u6279\u51c6\u3002<\/span><\/p>\n

10. \u622a\u81f311\u670828\u65e5\uff0cCDE\u6709\u5173\u4eff\u5236\u836f\u4e00\u81f4\u6027\u8bc4\u4ef7\u7d2f\u8ba1\u53d7\u7406\u53f7\u5df2\u8fbe598\u4e2a\uff0c\u6d89\u53ca218\u5bb6\u4f01\u4e1a\u7684185\u4e2a\u54c1\u79cd\uff0c\u603b\u8ba1\u901a\u8fc7\u54c1\u89c4121\u4e2a\u3002\u5176\u4e2d9\u6708\u300110\u6708\u4eff\u5236\u836f\u4e00\u81f4\u6027\u8bc4\u4ef7\u53d7\u7406\u53f7\u5747\u8fbe81\u4e2a\uff0c\u622a\u81f328\u65e5\uff0c11\u6708\u4efd\u53d7\u7406\u53f7\u6570\u91cf\u5df2\u8fbe71\u4e2a\u3002<\/span><\/p>\n

\n
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\u673a\u5236\/\u9776\u70b9\u7814\u7a76\u8fdb\u5c55<\/section>\n<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n

1. \u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u6cd5\u56fd\u548c\u7f8e\u56fd\u7684\u7814\u7a76\u4eba\u5458\u5c55\u793a\u4e86\u5355\u4e2a\u86cb\u767d\u5982\u4f55\u8bf1\u5bfc\u53e6\u4e00\u4e2a\u5206\u5b50\u53d1\u751f\u87ba\u65cb\u8fd0\u52a8\u3002\u901a\u8fc7\u591a\u7c73\u8bfa\u9aa8\u724c\u6548\u5e94\uff0c\u8fd9\u4f1a\u5bfc\u81f4\u7ec6\u80de\u3001\u5668\u5b98\u751a\u81f3\u6574\u4e2a\u8eab\u4f53\u53d1\u751f\u5377\u66f2\uff0c\u4ece\u800c\u89e6\u53d1\u504f\u4fa7\u884c\u4e3a\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u57282018\u5e7411\u670823\u65e5\u7684Science\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cMolecular to organismal chirality is induced by the conserved myosin 1D\u201d\u3002\u5728\u8fd9\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u5728\u679c\u8747\u7684\u6b63\u5e38\u60c5\u5f62\u4e0b\u662f\u4fdd\u6301\u5bf9\u79f0\u72b6\u6001\u7684\u5668\u5b98\uff08\u6bd4\u5982\u547c\u5438\u6c14\u7ba1\uff09\u4e2d\u8bf1\u5bfcMyo1D\u4ea7\u751f\u3002\u4ee4\u4eba\u5403\u60ca\u7684\u662f\uff0c\u8fd9\u8db3\u4ee5\u5f15\u8d77\u5404\u4e2a\u5c42\u9762\u7684\u4e0d\u5bf9\u79f0\u6027\uff1a\u8ba9\u7ec6\u80de\u53d8\u5f62\uff0c\u6c14\u7ba1\u7f20\u7ed5\u5728\u81ea\u8eab\u5468\u56f4\uff0c\u6574\u4e2a\u8eab\u4f53\u53d1\u751f\u626d\u66f2\uff0c\u4ee5\u53ca\u679c\u8747\u5e7c\u866b\u51fa\u73b0\u87ba\u65cb\u8fd0\u52a8\u884c\u4e3a\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u4e9b\u65b0\u7684\u4e0d\u5bf9\u79f0\u6027\u603b\u662f\u671d\u7740\u540c\u4e00\u4e2a\u65b9\u5411\u4ea7\u751f\u3002<\/span>
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2. \u6839\u636e\u82f1\u56fd\u764c\u75c7\u7814\u7a76\u6240\uff08ICR\uff09\u79d1\u5b66\u5bb6\u7684\u4e00\u9879\u6700\u65b0\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u82f1\u56fd\u9500\u552e\u7684\u4e00\u79cd\u975e\u5904\u65b9\u51cf\u80a5\u836f\u5965\u5229\u53f8\u4ed6\uff08Orlistat\uff09\u6709\u671b\u5e2e\u52a9\u5df2\u4ea7\u751f\u5316\u7597\u8010\u836f\u6027\u7684\u5375\u5de2\u764c\u60a3\u8005\u518d\u6b21\u5bf9\u5316\u7597\u4ea7\u751f\u6cbb\u7597\u53cd\u5e94\u3002\u7814\u7a76\u4eba\u5458\u5728\u5316\u7597\u8010\u836f\u5375\u5de2\u764c\u5c0f\u9f20\u6a21\u578b\u4e2d\u5f00\u5c55\u4e86\u8bd5\u9a8c\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u5965\u5229\u53f8\u4ed6\u5e2e\u52a9\u5375\u5de2\u764c\u53d8\u5f97\u5bf9\u5316\u7597\u836f\u7269\u987a\u94c2\uff08cisplatin\uff09\u654f\u611f\uff0c\u540c\u65f6\u5ef6\u7f13\u4e86\u80bf\u7624\u751f\u957f\u3002\u8fd9\u9879\u7814\u7a76\u5df2\u53d1\u8868\u4e8e\u300a\u56fd\u9645\u764c\u75c7\u6742\u5fd7\u300b\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c42\u671f\uff09\"<\/p>\n

3. \u6839\u636e2018\u5e7411\u6708\u53d1\u8868\u5728\u7f8e\u56fd\u6574\u5f62\u5916\u79d1\u5b66\u4f1a\uff08American Society of Plastic Surgeon\uff09\u5b98\u65b9\u671f\u520aPlastic and Reconstructive Surgery\u4e0a\u7684\u4e00\u7bc7\u6807\u9898\u4e3a\u201cCRISPR Craft: DNA Editing the Reconstructive Ladder\u201d\u7684\u8bba\u6587\uff0c\u6240\u6d89\u53ca\u7684\u533b\u5b66\u9886\u57df\u5305\u62ec\u6574\u5f62\u624b\u672f\uff0c\u8fd9\u79cd\u57fa\u56e0\u7ec4\u7f16\u8f91\u6280\u672f\u6709\u671b\u5728\u4ece\u9884\u9632\u9885\u9762\u7578\u5f62\u5230\u6cbb\u7597\u6027\u76ae\u80a4\u79fb\u690d\u518d\u5230\u65b0\u578b\u65e0\u6392\u65a5\u79fb\u690d\u7b49\u65b9\u9762\u53d6\u5f97\u6f5c\u5728\u7684\u8fdb\u5c55\u3002<\/span><\/p>\n

4. \u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u745e\u5178\u65af\u5fb7\u54e5\u5c14\u6469\u5927\u5b66\u3001\u5361\u7f57\u7433\u65af\u5361\u7814\u7a76\u6240\u3001\u6fb3\u5927\u5229\u4e9a\u56fd\u7acb\u5927\u5b66\u548c\u5fb7\u56fd\u9a6c\u514b\u65af\u666e\u6717\u514b\u5316\u5b66\u80fd\u8f6c\u6362\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u652f\u539f\u4f53\u75c5\u539f\u4f53\u4ee5\u4e00\u79cd\u72ec\u7279\u7684\u53ef\u80fd\u4fdd\u62a4\u5b83\u4eec\u514d\u53d7\u6211\u4eec\u7684\u514d\u75ab\u53cd\u5e94\u7684\u65b9\u5f0f\u5236\u9020DNA\u3002\u8fd9\u4e00\u7ed3\u679c\u53ef\u80fd\u63d0\u4f9b\u65b0\u7684\u9014\u5f84\u6765\u5bf9\u6297\u5229\u7528\u8fd9\u79cd\u7b56\u7565\u7684\u652f\u539f\u4f53\u75c5\u539f\u4f53\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u57282018\u5e7411\u670815\u65e5\u7684Nature\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cMetal-free ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens\u201d\u3002\u8bba\u6587\u901a\u8baf\u4f5c\u8005\u4e3a\u65af\u5fb7\u54e5\u5c14\u6469\u5927\u5b66\u751f\u7269\u5316\u5b66\u4e0e\u751f\u7269\u7269\u7406\u7cfb\u6559\u6388Martin H\u00f6gbom\u3002<\/span><\/p>\n

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\u7248\u6743\u58f0\u660e<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u6b22\u8fce\u4e2a\u4eba\u3001\u7f51\u7ad9\u3001\u516c\u4f17\u53f7\u7b49\u5f15\u7528\u3001\u8f6c\u8f7d\u548c\u5206\u4eab\u3002\u975e\u4e2a\u4eba\u8f6c\u8f7d\u6216\u5f15\u7528\u672c\u7f51\u7248\u6743\u6240\u6709\u5185\u5bb9\u987b\u83b7\u5f97\u6388\u6743\u5e76\u5728\u9192\u76ee\u5904\u6ce8\u660e\u201c\u8f6c\u81ea\uff1a\u201d\u3002\u6b22\u8fce\u5408\u4f5c\uff0c\u8bf7\u8054\u7cfbiddds@simm.ac.cn<\/span><\/strong><\/p>\n


<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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