{"id":60872,"date":"2018-11-26T01:00:00","date_gmt":"2018-12-07T03:02:17","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/ef3337492b\/"},"modified":"2018-12-07T11:02:18","modified_gmt":"2018-12-07T03:02:18","slug":"ef3337492b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/60872\/","title":{"rendered":"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c41\u671f\uff09"},"content":{"rendered":"
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\u56fd\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/section>\n<\/section>\n
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1. \u897f\u73ed\u7259\u5236\u836f\u516c\u53f8Almirall\u8fd1\u65e5\u5ba3\u5e03\uff0c\u5728\u5fb7\u56fd\u63a8\u51fa\u65b0\u6297\u708e\u836fIlumetri\uff08tildrakizumab\uff09\uff0c\u8be5\u836f\u7528\u4e8e\u9002\u5408\u7cfb\u7edf\u7597\u6cd5\u7684\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u6591\u5757\u578b\u94f6\u5c51\u75c5\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span>
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2. \u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u4eba\u7528\u533b\u836f\u4ea7\u54c1\u59d4\u5458\u4f1a\uff08CHMP\uff09\u5df2\u53d1\u5e03\u79ef\u6781\u610f\u89c1\uff0c\u63a8\u8350\u6279\u51c6\u6768\u68ee\u5236\u836fErleada\uff08apalutamide\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u5b58\u5728\u9ad8\u8f6c\u79fb\u98ce\u9669\u7684\u975e\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\uff08nmCRPC\uff09\u6210\u4eba\u60a3\u8005\u3002<\/span><\/p>\n

3. \u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6279\u51c6\u897f\u96c5\u56fe\u9057\u4f20\u5b66\u516c\u53f8\uff08Seattle Genetics\uff09\u6297\u4f53\u836f\u7269\u5076\u8054\u7269Adcetris\uff08brentuximab vedotin\uff09\u8054\u5408\u5316\u7597\u65b9\u6848CHP\uff08\u73af\u78f7\u9170\u80fa+\u963f\u9709\u7d20+\u5f3a\u7684\u677e\uff09\u4e00\u7ebf\u6cbb\u7597\u7cfb\u7edf\u6027\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\uff08sALCL\uff09\u6216\u5176\u4ed6CD30\u9633\u6027\u5916\u5468T\u7ec6\u80de\u6dcb\u5df4\u7624\uff08PTCL\uff0c\u5305\u62ec\u8840\u7ba1\u514d\u75ab\u6bcd\u7ec6\u80de\u6027T\u7ec6\u80de\u6dcb\u5df4\u7624[AITL]\u4ee5\u53ca\u672a\u53e6\u884c\u7279\u522b\u8bf4\u660e\u7684PTCL\uff09\u6210\u4eba\u60a3\u8005\u3002<\/span><\/p>\n

4. \u827e\u4f2f\u7ef4\uff08AbbVie\uff09\u4e0eNeurocrine Biosciences\u8054\u5408\u516c\u5e03\u4e86\u65b0\u836felagolix\u5728\u4e24\u9879\u5173\u952e3\u671f\u8bd5\u9a8cELARIS UF-1\uff08M12-815\uff09\u548cELARIS UF-2\uff08M12-817\uff09\u4e2d\uff0c\u7528\u4e8e\u6cbb\u7597\u5b50\u5bab\u808c\u7624\u76f8\u5173\u7684\u91cd\u5ea6\u6708\u7ecf\u51fa\u8840\u7684\u8fdb\u4e00\u6b65\u6570\u636e\u7ed3\u679c\u3002<\/span><\/p>\n

5. FDA\u5df2\u6279\u51c6\u6269\u5927\u514d\u75ab\u836f\u7269Promacta\uff08eltrombopag\uff0c\u827e\u66f2\u6ce2\u5e15\uff09\u7684\u9002\u5e94\u75c7\u6807\u7b7e\uff0c\u8054\u5408\u6807\u51c6\u514d\u75ab\u6291\u5236\u7597\u6cd5\uff08IST\uff09\u7528\u4e8e2\u5c81\u53ca\u4ee5\u4e0a\u513f\u7ae5\u548c\u6210\u4eba\u91cd\u5ea6\u518d\u751f\u969c\u788d\u6027\u8d2b\u8840\uff08SAA\uff09\u7684\u4e00\u7ebf\u6cbb\u7597\u6cbb\u7597\u3002\u6b64\u6b21\u6279\u51c6\uff0c\u4f7fPromacta\u6210\u4e3a\u7f8e\u56fd\u5e02\u573a\u5341\u591a\u5e74\u6765\u6279\u51c6\u7528\u4e8e\u65b0\u8bcaSAA\u60a3\u8005\u7684\u9996\u4e2a\u65b0\u836f\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c41\u671f\uff09\"<\/p>\n

6. \u65e5\u524d\uff0cIonis Pharmaceuticals\u53ca\u5176\u5b50\u516c\u53f8Akcea Therapeutics\u5ba3\u5e03\u4e86AKCEA-APO(a)-LRx\u76842\u671f\u4e34\u5e8a\u7814\u7a76\u5728\u5df2\u786e\u8bca\u5fc3\u8840\u7ba1\u75be\u75c5\uff08CVD\uff09\u548c\u8102\u86cb\u767d(a)\u2014\u2014Lp(a)\u6c34\u5e73\u5347\u9ad8\u60a3\u8005\u4e2d\u7684\u6570\u636e\u3002\u8be5\u7814\u7a76\u57286\u4e2a\u6708\u65f6\u62b5\u8fbe\u6240\u6709\u4e3b\u8981\u7ec8\u70b9\u548c\u6b21\u8981\u7ec8\u70b9\u3002\u8be5\u7814\u7a76\u663e\u793a\uff0cLp(a)\u6c34\u5e73\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u548c\u5242\u91cf\u4f9d\u8d56\u6027\u964d\u4f4e\u3002\u7ea6\u670998%\u7684\u63a5\u53d7\u6700\u9ad8\u5242\u91cf\u6cbb\u7597\u60a3\u8005\u7684Lp(a)\u6c34\u5e73\u964d\u4f4e\u81f3CVD\u4e8b\u4ef6\u98ce\u9669\u9608\u503c\u4ee5\u4e0b\u3002<\/span><\/p>\n

7. \u9ed8\u514b\u548c\u8f89\u745e11\u670819\u65e5\u5ba3\u5e03\uff0c\u4e0e\u805a\u4e59\u4e8c\u9187\u5316\u591a\u67d4\u6bd4\u661f\u8102\u8d28\u4f53\uff08PLD\uff0c\u4e00\u79cd\u5316\u7597\u7c7b\u578b\uff09\u76f8\u6bd4\uff0cBavencio\uff08avelumab\uff09\u5355\u836f\u6216\u8054\u5408PLD\u7528\u4e8e\u94c2\u7c7b\u8010\u836f\u6216\u96be\u6cbb\u6027\u5375\u5de2\u764c\u60a3\u8005\u6cbb\u7597\u7684\u4e34\u5e8aIII\u671fJAVELIN Ovarian 200\u7814\u7a76\u6ca1\u6709\u8fbe\u5230\u603b\u751f\u5b58\u671f\uff08OS\uff09\u6216\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u7684\u9884\u5b9a\u4e3b\u8981\u7ec8\u70b9\u3002<\/span><\/p>\n

8. \u81f4\u529b\u4e8e\u63d0\u4f9b\u5177\u6709\u6539\u53d8\u4e25\u91cd\u75be\u75c5\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\u7684\u5168\u7403\u9996\u521b\u7597\u6cd5\u7684\u82f1\u56fd\u751f\u7269\u79d1\u6280\u516c\u53f8Immunocore\u8868\u793a\uff0c\u516c\u53f8\u5df2\u4e0e\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u8fbe\u6210\u4e86\u4e00\u9879\u65b0\u7684\u7814\u53d1\u5408\u4f5c\u534f\u8bae\uff0c\u53cc\u65b9\u5c06\u5bf9Immunocore\u7684\u5019\u9009\u836f\u7269IMC-C103C\u8fdb\u884c\u5171\u540c\u5f00\u53d1\u3002\u8be5\u5019\u9009\u836f\u7269\u662f\u4e00\u6b3e\u9776\u5411\u80bf\u7624\u8868\u8fbe\u7684MAGE-A4\u86cb\u767d\u7684ImmTAC\u00ae\u5206\u5b50\u3002<\/span><\/p>\n

9. Sobi\u548cNovimmune SA\u516c\u53f8\u8054\u5408\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u6279\u51c6\u53cc\u65b9\u5171\u540c\u5f00\u53d1\u7684\u5e72\u6270\u7d20\u03b3\uff08IFN\u03b3\uff09\u6297\u4f53Gamifant\uff08emapalumab-lzsg\uff09\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u513f\u7ae5\u6216\u6210\u5e74\u539f\u53d1\u6027\u566c\u8840\u7ec6\u80de\u6dcb\u5df4\u7ec4\u7ec7\u7ec6\u80de\u589e\u591a\u75c7\uff08HLH\uff09\u60a3\u8005\u3002\u8fd9\u4e9b\u60a3\u8005\u60a3\u6709\u590d\u53d1\/\u96be\u6cbb\u6027\u75be\u75c5\uff0c\u5728\u63a5\u53d7\u5e38\u89c4HLH\u7597\u6cd5\u540e\u75be\u75c5\u7ee7\u7eed\u6076\u5316\uff0c\u6216\u5bf9\u5e38\u89c4\u7597\u6cd5\u4e0d\u8010\u53d7\u3002Gamifant\u662fFDA\u6279\u51c6\u7684\u9996\u4f8b\u9488\u5bf9HLH\u7684\u7597\u6cd5\uff0c\u8fd9\u4ee3\u8868\u7740\u6cbb\u7597\u539f\u53d1\u6027HLH\u9886\u57df24\u5e74\u6765\u7684\u9996\u4e2a\u91cd\u5927\u7a81\u7834\u3002<\/span><\/p>\n

10. \u7f8e\u56fdFDA\u5ba3\u5e03\u6279\u51c6\u8f89\u745e\uff08Pfizer\uff09\u516c\u53f8\u5f00\u53d1\u7684Daurismo\uff08glasdegib\uff09\u4e0a\u5e02\uff0c\u4e0e\u4f4e\u5242\u91cf\u963f\u7cd6\u80de\u82f7\uff08LDAC\uff09\u5316\u7597\u8054\u7528\uff0c\u6cbb\u7597\u65b0\u786e\u8bca\u768475\u5c81\u4ee5\u4e0a\uff0c\u6216\u56e0\u6162\u6027\u5065\u5eb7\u95ee\u9898\u548c\u75be\u75c5\u65e0\u6cd5\u4f7f\u7528\u9ad8\u5f3a\u5ea6\u5316\u7597\uff08intensive chemotherapy\uff09\u7684\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff08AML\uff09\u60a3\u8005\u3002<\/span><\/p>\n

11. \u827e\u4f2f\u7ef4\uff08AbbVie\uff09\u548c\u7f57\u6c0f\uff08Roche\uff09\u65d7\u4e0b\u57fa\u56e0\u6cf0\u514b\uff08Genentech\uff09\u516c\u53f8\u5171\u540c\u5ba3\u5e03\uff0cFDA\u52a0\u901f\u6279\u51c6\u53cc\u65b9\u5171\u540c\u5f00\u53d1\u7684Venclexta\uff08venetoclax\uff09\uff0c\u4e0e\u4f4e\u7532\u57fa\u5316\u5242\uff08azacitidine\u6216decitabine\uff09\uff0c\u6216\u4f4e\u5242\u91cf\u963f\u7cd6\u80de\u82f7\uff08LDAC\uff09\u5316\u7597\u8054\u7528\uff0c\u6cbb\u7597\u65b0\u786e\u8bca75\u5c81\u4ee5\u4e0a\uff0c\u6216\u56e0\u4e3a\u6162\u6027\u5065\u5eb7\u95ee\u9898\u548c\u75be\u75c5\u65e0\u6cd5\u4f7f\u7528\u9ad8\u5f3a\u5ea6\u5316\u7597\uff08intensive chemotherapy\uff09\u7684\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff08AML\uff09\u60a3\u8005\u3002<\/span><\/p>\n

12. Sage Therapeutics\u516c\u53f8\u53d1\u51fa\u516c\u544a\u79f0\uff1aFDA\u5ef6\u957f\u4e86\u5176\u7528\u4e8e\u6cbb\u7597\u4ea7\u540e\u6291\u90c1\u75c7\u7684\u65b0\u836fZulress\uff08brexanolone\uff09\u6ce8\u5c04\u5242\u7684\u65b0\u836f\u7533\u8bf7\u4f18\u5148\u5ba1\u67e5\u7684PDUFA\u65e5\u671f\u3002\u8fd9\u610f\u5473\u7740\uff0c\u5148\u524d\u62ab\u9732\u76842018\u5e7412\u670819\u65e5PDUFA\u5c06\u5ef6\u957f\u4e09\u4e2a\u6708\u81f32019\u5e743\u670819\u65e5\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c41\u671f\uff09\"<\/p>\n

13. \u5728\u7b2c30\u5c4aEORTC-NCI-AACR\u5206\u5b50\u9776\u70b9\u548c\u764c\u75c7\u6cbb\u7597\u7814\u8ba8\u4f1a\u4e0a\uff0cZymeworks\u516c\u53f8\u66f4\u65b0\u5176\u65b0\u578b\u6297HER2\u65b0\u836f–ZW25\uff0c\u5728\u98df\u9053\u764c\u3001\u80c3\u764c\u3001\u80a0\u764c\u548cHER2\u9a71\u52a8\u7684\u5176\u4ed6\u51e0\u79cd\u764c\u75c7\u4e0a\u7684\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u3002ZW25\u5728\u591a\u79cd\u8868\u8fbeHER2\u7684\u80bf\u7624\u7c7b\u578b\u4e2d\u5177\u6709\u6d3b\u6027\u548c\u826f\u597d\u7684\u8010\u53d7\u6027\uff1b\u5728\u786e\u8ba4\u7684\u90e8\u5206\u53cd\u5e94\u4e2d\u5177\u6709\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u5927\u4e8e\u516d\u4e2a\u6708\uff1b82%\u7684\u91cd\u5ea6\u9884\u5904\u7406\u60a3\u8005\u7684\u75be\u75c5\u5f97\u5230\u63a7\u5236\u3002<\/span><\/p>\n

14. \u745e\u58eb\u5236\u836f\u5de8\u5934\u8bfa\u534e\uff08Novartis\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u6b27\u76df\u59d4\u5458\u4f1a\uff08EC\uff09\u5df2\u6279\u51c6Luxturna\uff08voretigene neparvovec\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u4e00\u6b21\u6027\u57fa\u56e0\u7597\u6cd5\uff0c\u7528\u4e8e\u6cbb\u7597\u56e0\u53cc\u62f7\u8d1dRPE65\u57fa\u56e0\u7a81\u53d8\u6240\u81f4\u89c6\u529b\u4e27\u5931\u4f46\u4fdd\u7559\u6709\u8db3\u591f\u6570\u91cf\u7684\u5b58\u6d3b\u89c6\u7f51\u819c\u7ec6\u80de\u7684\u513f\u7ae5\u548c\u6210\u4eba\u60a3\u8005\uff0c\u6062\u590d\u548c\u6539\u5584\u89c6\u529b\u3002\u6b64\u6b21\u6279\u51c6\uff0c\u4f7fLuxturna\u6210\u4e3a\u6b27\u6d32\u83b7\u6279\u6cbb\u7597\u9057\u4f20\u6027\u89c6\u7f51\u819c\u75be\u75c5\uff08IRD\uff09\u7684\u9996\u4e2a\u57fa\u56e0\u7597\u6cd5\u3002<\/span><\/p>\n

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\u56fd\u5185\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/section>\n<\/section>\n
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1. \u5409\u5229\u5fb7\u4e59\u809d\u65b0\u836f\u78f7\u4e19\u66ff\u8bfa\u798f\u97e6\u7247\uff08TAF\uff09 \u7684\u65b0\u836f\u7533\u8bf7\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u7684\u6ce8\u518c\u6279\u4ef6\uff0c\u83b7\u51c6\u901a\u8fc7\u65e5\u670d\u4e00\u6b21\u7684\u65b9\u5f0f\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u548c\u9752\u5c11\u5e74\uff0812\u5c81\u4ee5\u4e0a\uff0c\u4f53\u91cd\u8d85\u8fc735kg\uff09\u6162\u6027\u4e59\u578b\u809d\u708e\u3002<\/span>
<\/p>\n

2. \u5065\u5eb7\u5143\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u516c\u53f8\u53ca\u5168\u8d44\u5b50\u516c\u53f8\u592a\u592a\u836f\u4e1a\u6536\u5230\u56fd\u5bb6\u836f\u76d1\u5c40\u6838\u51c6\u7b7e\u53d1\u7684\u5173\u4e8e\u5bcc\u9a6c\u9178\u798f\u83ab\u7279\u7f57\u5438\u5165\u6eb6\u6db2\u4ee5\u53ca\u5e03\u5730\u5948\u5fb7\u5438\u5165\u6df7\u60ac\u6db2\u7684\u300a\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u901a\u77e5\u4e66\u300b\u3002\u636e\u6089\uff0c\u5bcc\u9a6c\u9178\u798f\u83ab\u7279\u7f57\u5438\u5165\u6eb6\u6db2\u4e3a\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u4ea7\u54c1\uff0c\u56fd\u5185\u5e02\u573a\u76ee\u524d\u4ec5\u6709\u7247\u5242\u53ca\u7c89\u5438\u5165\u5242\uff1b\u5438\u5165\u7528\u5e03\u5730\u5948\u5fb7\u6df7\u60ac\u6db2\u6700\u65e9\u7531\u963f\u65af\u5229\u5eb7\u7814\u5236\u751f\u4ea7\uff0c2017\u5e74\u5728\u4e2d\u56fd\u516c\u7acb\u533b\u7597\u673a\u6784\u7ec8\u7aef\u9500\u552e\u989d\u63a5\u8fd166\u4ebf\u5143\u3002<\/span><\/p>\n

3. \u4e0a\u6d77\u7f57\u6c0f\u5236\u836f\u6709\u9650\u516c\u53f8\uff08\u7f57\u6c0f\uff09\u4e0e\u6b4c\u793c\u751f\u7269\u79d1\u6280\uff08\u676d\u5dde\uff09\u6709\u9650\u516c\u53f8\u4eca\u65e5\u5171\u540c\u5ba3\u5e03\uff0c\u81ea2018\u5e7412\u67081\u65e5\u8d77\uff0c\u53cc\u65b9\u5c06\u8fdb\u4e00\u6b65\u62d3\u5c55\u5728\u75c5\u6bd2\u6027\u809d\u708e\u9886\u57df\u7684\u5408\u4f5c\u3002\u7ee7\u9996\u8f6e\u6210\u529f\u5408\u4f5c\u548c\u6208\u8bfa\u536b\uff08\u8fbe\u8bfa\u745e\u97e6\uff09\u6210\u529f\u4e0a\u5e02\u540e\uff0c\u6b4c\u793c\u548c\u7f57\u6c0f\u51b3\u5b9a\u5c31\u6d3e\u7f57\u6b23\u5f00\u5c55\u65b0\u7684\u5408\u4f5c\u3002\u7f57\u6c0f\u5c06\u5176\u5177\u6709\u5e02\u573a\u9886\u5148\u5730\u4f4d\u7684\u3001\u7528\u4e8e\u4e59\u809d\u548c\u4e19\u809d\u6cbb\u7597\u7684\u957f\u6548\u5e72\u6270\u7d20–\u6d3e\u7f57\u6b23\u4e2d\u56fd\u5927\u9646\u5730\u533a\u7684\u72ec\u5bb6\u9500\u552e\u3001\u5e02\u573a\u63a8\u5e7f\u6743\u5229\u6388\u4e88\u6b4c\u793c\u3002<\/span><\/p>\n

4. CDE\u627f\u529e\u53d7\u7406\u7eff\u8c37\u5236\u836f\u91cd\u78c5\u963f\u5c14\u5179\u6d77\u9ed8\u75c71\u7c7b\u65b0\u836f\u7518\u9732\u5be1\u7cd6\u4e8c\u9178\uff08GV-971\uff09\u4e0a\u5e02\u7533\u8bf7\uff0c\u6b64\u6b21\u7533\u8bf7\u9002\u5e94\u75c7\u4e3a\u8f7b\u4e2d\u5ea6\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u3002\u7518\u9732\u5be1\u7cd6\u4e8c\u9178\uff08GV-971\uff09\u662f\u8fd1\u5e74\u4e2d\u56fd\u56fd\u5185\u81ea\u4e3b\u5f00\u53d1\u7684\u91cd\u78c5\u521b\u65b0\u836f\u3002\u8fd9\u6807\u5fd7\u7740\u4e2d\u56fd1\u7c7b\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u836f\u7269\u6b63\u5f0f\u8fdb\u5165\u4e0a\u5e02\u5ba1\u8bc4\u9636\u6bb5\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c41\u671f\uff09\"<\/p>\n

5. 11\u670823\u65e5\uff0c\u62dc\u8033\u524d\u5217\u817a\u764c\u65b0\u836fXofigo\uff08\u6c2f\u5316\u956d[223Ra]\u6ce8\u5c04\u6db2\uff09\u7684\u4e0a\u5e02\u7533\u8bf7\u83b7\u5f97CDE\u6b63\u5f0f\u627f\u529e\u53d7\u7406\u3002<\/span><\/p>\n

6. 11\u670823\u65e5\uff0c\u897f\u5b89\u6768\u68ee\u5ba3\u5e03\u65d7\u4e0b\u4ebf\u73c2\uff08\u4f0a\u5e03\u66ff\u5c3c\u80f6\u56ca\uff09\u65b0\u9002\u5e94\u75c7\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\uff0c\u53ef\u5355\u836f\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u60a3\u8005\u7684\u6cbb\u7597\uff0c\u6216\u8005\u4e0d\u9002\u5408\u63a5\u53d7\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u7684\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0e\u5229\u59a5\u6614\u5355\u6297\u8054\u7528\uff0c\u7528\u4e8e\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u60a3\u8005\u7684\u6cbb\u7597\u3002\u4ebf\u73c2\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u9002\u5e94\u75c7\u7684\u7533\u8bf7\u88ab\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6388\u4e88\u201c\u4f18\u5148\u5ba1\u8bc4\u201d\u8d44\u683c\u3002\u968f\u7740\u6b64\u6b21\u83b7\u6279\uff0c\u4ebf\u73c2\u6210\u4e3a\u56fd\u5185\u9996\u4e2a\u4e5f\u662f\u76ee\u524d\u552f\u4e00\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u7684\u9776\u5411\u53e3\u670d\u836f\u7269\u3002\u6b64\u524d\uff0c\u4ebf\u73c2\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u9002\u5e94\u75c7\u83b7\u5f97\u7f8e\u56fdFDA\u6388\u4e88\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u4e5f\u662f\u76ee\u524d\u7f8e\u56fd\u548c\u6b27\u6d32\u552f\u4e00\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u60a3\u8005\u7684\u836f\u7269\u3002<\/span><\/p>\n

\n
\n
\n
\n
\u673a\u5236\u9776\u70b9\u7814\u7a76\u8fdb\u5c55<\/section>\n<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n

1. \u6700\u8fd1\u6765\u81ea\u65e5\u672c\u4e1c\u4eac\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5bf9SERM\u7684\u4f5c\u7528\u673a\u5236\u8fdb\u884c\u4e86\u66f4\u6df1\u5165\u7684\u63a2\u8ba8\uff0c\u76f8\u5173\u7ed3\u679c\u53d1\u8868\u5728\u56fd\u9645\u5b66\u672f\u671f\u520aJCI\u4e0a\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u4e00\u7cfb\u5217\u63a7\u5236ER\u548c\u5171\u56e0\u5b50\u52a8\u6001\u6027\u4ee5\u53caSERM\u529f\u80fd\u7684\u8c03\u63a7\u673a\u5236\uff0c\u4ed6\u4eec\u8fd8\u53d1\u73b0SERM\u6d3b\u6027\u53d1\u6325\u9700\u8981Fbxo22\u7684\u53c2\u4e0e\u3002SCF Fbxo22\u80fd\u591f\u5bf9\u8d56\u6c28\u9178\u53bb\u7532\u57fa\u91764B\uff08KDM4B\uff09\u8fdb\u884c\u6cdb\u7d20\u5316\uff0c\u800c\u5728\u53d1\u751f\u6cdb\u7d20\u5316\u4e4b\u524dKDM4B\u4e0e\u7ed3\u5408\u4e86\u4ed6\u83ab\u6614\u82ac\u7684ER\u5f62\u6210\u590d\u5408\u4f53\u7684\uff0cKDM4B\u7684\u964d\u89e3\u80fd\u591f\u4eceER\u590d\u5408\u4f53\u4e0a\u91ca\u653e\u9664\u7c7b\u56fa\u9187\u53d7\u4f53\u5171\u6fc0\u6d3b\u56e0\u5b50\uff08SRC\uff09\u3002<\/span>
<\/p>\n

2. \u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u65d7\u4e0b\u7684\u300aCancer Research\u300b\u671f\u520a\u5728\u7ebf\u53d1\u8868\u4e86\u4e00\u7bc7\u5f15\u8d77\u5e7f\u6cdb\u5173\u6ce8\u7684\u8bba\u6587\u3002\u7531\u82f1\u56fd\u725b\u6d25\u5927\u5b66\u9886\u5bfc\u7684\u4e00\u652f\u79d1\u7814\u56e2\u961f\u5c06\u4e00\u79cd\u6eb6\u7624\u75c5\u6bd2\u6539\u9020\u6210\u4e86\u523a\u5411\u80bf\u7624\u7684\u5229\u77db\uff0c\u80fd\u6345\u7834\u4fdd\u62a4\u764c\u7ec6\u80de\u7684\u62a4\u76fe\u3002\u5728\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u4eec\u6210\u529f\u6539\u9020\u4e86\u4e00\u79cd\u53eb\u505aenadenotucirev\u7684\u6eb6\u7624\u75c5\u6bd2\u3002\u7ecf\u8fc7\u6539\u9020\uff0c\u8fd9\u79cd\u75c5\u6bd2\u80fd\u8868\u8fbe\u4e00\u7c7b\u7279\u6b8a\u7684\u86cb\u767d\u8d28\u3002\u5b83\u7684\u4e00\u7aef\u80fd\u7ed3\u5408\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u8868\u9762\u7684FAP\u86cb\u767d\uff0c\u53e6\u4e00\u7aef\u80fd\u7ed3\u5408\u514d\u75abT\u7ec6\u80de\u8868\u9762\u7684CD3\u03b5\u3002<\/span><\/p>\n

3. \u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u82f1\u56fd\u725b\u6d25\u5927\u5b66\u548c\u4f26\u6566\u5e1d\u56fd\u7406\u5de5\u5b66\u9662\u7b49\u7814\u7a76\u673a\u6784\u7684\u7814\u7a76\u4eba\u5458\u8bc1\u5b9e\u5229\u7528\u8d28\u8c31\u65b9\u6cd5\u80fd\u591f\u5206\u6790\u819c\u5185\u4f5c\u4e3a\u4e00\u4e2a\u6574\u4f53\u5b58\u5728\u7684\u5b8c\u6574\u86cb\u767d\u673a\u5668\u7684\u7ed3\u6784\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u57282018\u5e7411\u670816\u65e5\u7684Science\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cProtein assemblies ejected directly from native membranes yield complexes for mass spectrometry\u201d\u3002<\/span><\/p>\n

4. \u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u7684\u7814\u7a76\u4eba\u5458\u8bbe\u8ba1\u51fa\u4e00\u79cd\u57fa\u4e8eCRISPR\u7684\u79f0\u4e3aSLICE\uff08single guide RNA lentiviral infection with Cas9 protein electroporation, \u5373\u5229\u7528Cas9\u86cb\u767d\u7535\u7a7f\u5b54\u8fdb\u884c\u5355\u5411\u5bfcRNA\u6162\u75c5\u6bd2\u611f\u67d3\uff09\u7684\u7cfb\u7edf\uff0c\u8fd9\u79cd\u7cfb\u7edf\u5c06\u4f7f\u5f97\u79d1\u5b66\u5bb6\u4eec\u80fd\u591f\u5feb\u901f\u8bc4\u4f30\u76f4\u63a5\u4ece\u60a3\u8005\u4f53\u5185\u63d0\u53d6\u51fa\u7684\u201c\u539f\u4ee3\u201d\u514d\u75ab\u7ec6\u80de\u4e2d\u6bcf\u4e2a\u57fa\u56e0\u7684\u529f\u80fd\u3002\u8fd9\u79cd\u65b0\u65b9\u6cd5\u4e3a\u79d1\u5b66\u5bb6\u4eec\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5f3a\u5927\u7684\u5de5\u5177\uff0c\u80fd\u591f\u5728\u786e\u5b9a\u5982\u4f55\u6700\u597d\u5730\u6539\u9020\u514d\u75ab\u7ec6\u80de\u6765\u5bf9\u6297\u764c\u75c7\u548c\u4e00\u7cfb\u5217\u5176\u4ed6\u75be\u75c5\u65f6\u6307\u5bfc\u4ed6\u4eec\u4f5c\u51fa\u51b3\u7b56\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e7411\u670815\u65e5\u5728\u7ebf\u53d1\u8868\u5728\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cGenome-wide CRISPR Screens in Primary Human T s Reveal Key Regulators of Immune Function\u201d\u3002<\/span><\/p>\n

\n

5. \u8fd1\u671f\uff0c\u6fb3\u5927\u5229\u4e9a\u513f\u7ae5\u764c\u75c7\u7814\u7a76\u6240\uff08Children\u2019s Cancer Institute Australia for Medical Research\uff09\u7684Murray Norris\u6559\u6388\u5728\u7b2c30\u5c4a\u56fd\u9645\u5206\u5b50\u9776\u6807\u4e0e\u764c\u75c7\u6cbb\u7597\u5b66\u7814\u8ba8\u4f1a\uff08EORTC-NCI-AACR\uff09\u4e0a\u62a5\u544a\u4e86\u4e00\u5f15\u4eba\u6ce8\u76ee\u7684\u5b9e\u9a8c\u7ed3\u679c\u3002\u5728\u8054\u5408\u4f7f\u7528CBL0137\u548c\u5e15\u6bd4\u53f8\u4ed6\u4e24\u79cd\u836f\u7269\u4e4b\u540e\uff0c\u5c0f\u9f20\u4f53\u5185\u7684\u80bf\u7624\u6d88\u5931\uff0c\u5e76\u4e14\u5728\u6574\u4e2a\u5b9e\u9a8c\u89c2\u5bdf\u671f\u95f4\u518d\u672a\u590d\u73b0\uff1b\u5728\u672a\u63a5\u53d7\u6cbb\u7597\u6216\u53ea\u63a5\u53d7\u5355\u4e00\u836f\u7269\u6cbb\u7597\u7684\u5bf9\u7167\u7ec4\u5c0f\u9f20\u4e2d\uff0c\u80bf\u7624\u5219\u6301\u7eed\u751f\u957f\u3002<\/span><\/p>\n

6. \u4e3a\u4e86\u521b\u9020\u5177\u6709\u957f\u671f\u8bb0\u5fc6\u53cd\u5e94\u800c\u4e0d\u4f1a\u6162\u6027\u6d88\u8017B\u7ec6\u80de\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\uff0c\u6765\u81ea\u7f8e\u56fdScripps\u7814\u7a76\u6240\u5206\u652f\u673a\u6784\u52a0\u5229\u798f\u5c3c\u4e9a\u751f\u7269\u533b\u5b66\u7814\u7a76\u6240\uff08Calibr\uff09\u7684\u79d1\u5b66\u5bb6\u5df2\u5f00\u53d1\u51fa\u4e86\u5e26\u6709\u201c\u5f00\u5173\u201d\u7684CAR\uff08sCAR\uff09T\u7ec6\u80de\u5e73\u53f0\uff0c\u8be5\u5e73\u53f0\u5141\u8bb8\u4f7f\u7528\u57fa\u4e8e\u6297\u4f53\u7684\u5f00\u5173\u5bf9sCAR-T\u7ec6\u80de\u6d3b\u6027\u8fdb\u884c\u5242\u91cf\u6ef4\u5b9a\u63a7\u5236\u3002\u5728\u6ca1\u6709\u8fde\u7eed\u7684\u6297\u539f\u523a\u6fc0\u7684\u60c5\u51b5\u4e0b\uff0c\u8fd9\u79cd\u914d\u7f6e\u5c06\u5141\u8bb8sCAR-T\u7ec6\u80de\u201c\u4f11\u606f\u201d\uff0c\u8fd9\u5bf9\u4e8e\u7a33\u5065\u7684\u8bb0\u5fc6\u5f62\u6210\u662f\u5fc5\u987b\u7684\uff0c\u5e76\u7ed9\u4e88B\u7ec6\u80de\u8865\u5145\u7684\u673a\u4f1a\u3002<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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