{"id":60896,"date":"2018-11-19T01:00:00","date_gmt":"2018-12-07T03:02:34","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/d79dfedf8d\/"},"modified":"2018-12-07T11:02:39","modified_gmt":"2018-12-07T03:02:39","slug":"d79dfedf8d","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/60896\/","title":{"rendered":"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;text-align: left;text-indent: 0em;\"><br  \/><\/p>\n<section style=\"display:flex;justify-content:center;\">\n<section>\n<section style=\"display:flex;justify-content:center;\">\u8f6c\u81ea\uff1aCPhI\u5236\u836f\u5728\u7ebf<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"display:none;\"><br  \/><\/p>\n<section style=\"box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(95, 156, 239);padding: 10px;background-color: rgb(239, 239, 239);box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"font-size: 14px;text-align: justify;padding-right: 6px;padding-left: 6px;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">10\u670819\u65e5\uff0c\u7ebd\u7ea6\u764c\u75c7\u7814\u7a76\u6240\uff08CRI\uff0cCancer Research Institute\uff09\u518d\u6b21\u516c\u5e03\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\u8c03\u67e5\u62a5\u544a\uff0c\u53d1\u8868\u4e8e\u300aNature Reviews Drug Discovery\u300b\u671f\u520a\u3002\u57281\u5e74\u5185\uff0c\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5168\u7403\u9879\u76ee\u6570\u589e\u52a067\uff05\uff0c\u9776\u70b9\u6570\u589e\u52a050\uff05\uff0c\u6709\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\u7684\u4f01\u4e1a\u4e0e\u673a\u6784\u6570\u589e\u52a042%\uff0c\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u84ec\u52c3\u53d1\u5c55\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">2011\u5e74ipilimumab\u83b7\u6279\u7528\u4e8e\u9ed1\u8272\u7d20\u7624\u6cbb\u7597\uff0c\u6807\u5fd7\u7740\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9769\u547d\u7684\u5f00\u59cb\uff0c\u5e76\u9010\u6e10\u6539\u53d8\u7740\u764c\u75c7\u6cbb\u7597\u8303\u5f0f\u3002\u76ee\u524d\u4e3a\u6b62\uff0c\u5df2\u670911\u79cd\u65b0\u7684\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u83b7\u6279\uff0c\u5e76\u6210\u4e3a\u591a\u79cd\u764c\u75c7\u7684\u6cbb\u7597\u6807\u51c6\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7ebd\u7ea6\u764c\u75c7\u7814\u7a76\u6240\u4f5c\u4e3a\u4e00\u5bb6\u81f4\u529b\u4e8e\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7814\u7a76\u8d85\u8fc765\u5e74\u7684\u975e\u8425\u5229\u7ec4\u7ec7\uff0c\u66fe\u57282017\u5e74\u5728\u5bf9\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u73b0\u72b6\u8fdb\u884c\u4e86\u5168\u9762\u8c03\u67e5\uff08Ann.Oncol.29,84-89\uff1b2017\uff09\u3002\u65f6\u9694\u4e00\u5e74\uff0c\u518d\u6b21\u5f00\u5c55\u4e86\u5927\u89c4\u6a21\u8c03\u67e5\u3002\u5728\u672c\u62a5\u544a\u4e2d\uff0c\u7814\u7a76\u5c0f\u7ec4\u5bf9\u8fd9\u4e24\u9879\u8c03\u67e5\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u5e76\u5bf9\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u8d8b\u52bf\u8fdb\u884c\u4e86\u7eb5\u5411\u5206\u6790\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"border-width: 3px;border-style: solid;border-color: rgb(95, 156, 239);padding: 3px;box-sizing: border-box;\">\n<section style=\"border-color: rgb(128, 128, 128);border-width: 1px;border-style: solid;padding: 10px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 16px;color: rgb(95, 156, 239);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u8d8b\u52bf\u4e00\uff1a\u5168\u7403\u80bf\u7624\u514d\u75ab\u7814\u53d1\u9879\u76ee\u589e\u957f\u8fc5\u901f\uff0c\u8fbe67\uff05<\/strong><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8fc7\u53bb\u4e00\u5e74\uff082017\u5e749\u6708&#8211;2018\u5e749\u6708\uff09\uff0c\u5168\u7403\u514d\u75ab\u6cbb\u7597\u7684\u7814\u53d1\u9879\u76ee\u589e\u52a0\u4e8667\uff05\uff082031\u9879\uff082017\u5e74\uff09vs 3394\u9879\uff082018\u5e74\uff09\uff09\u3002\u6839\u636e\u4e0d\u540c\u7684\u4f5c\u7528\u673a\u5236\u53ef\u5c06\u514d\u75ab\u6cbb\u7597\u836f\u7269\u5206\u4e3a\u516d\u7c7b\uff1a<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u2022 \u9776\u5411T\u7ec6\u80de\u514d\u75ab\u8c03\u8282\u5242\uff08\u4f8b\u5982\uff0cPD1\u6216CTLA4\u7684\u5355\u514b\u9686\u6297\u4f53\uff09\uff1b<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u2022 \u5176\u4ed6\u514d\u75ab\u8c03\u8282\u5242\uff08\u4f8b\u5982\uff0cTLR\u6216\u5e72\u6270\u7d20-\u03b1\/\u03b2\u53d7\u4f531\uff08IFNAR1\uff09\u7684\u6fc0\u52a8\u5242\uff09\uff1b<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u2022 \u80bf\u7624\u75ab\u82d7\uff08\u4f8b\u5982\uff0c\u5361\u4ecb\u82d7\uff08BCG\uff09\u75ab\u82d7\uff09\uff1b<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u2022 \u7ec6\u80de\u7597\u6cd5\uff08\u4f8b\u5982\uff0c\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09\u6216T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09T\u7ec6\u80de\u7597\u6cd5\uff09\uff1b<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u2022 \u6eb6\u7624\u75c5\u6bd2\uff08\u4f8b\u5982\uff0cT-vec\uff09\uff1b<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u2022 CD3\u9776\u5411\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff08\u4f8b\u5982\uff0cblinatumomab\uff09\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u516d\u5927\u4e0d\u540c\u7c7b\u522b\u514d\u75ab\u7597\u6cd5\u4e2d\uff0c\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u589e\u901f\u6700\u5feb\uff0c\u8fbe\u5230113\uff05\uff0c\u800c\u6eb6\u7624\u75c5\u6bd2\u53ea\u589e\u52a0\u4e8616\uff05\uff0c\u589e\u957f\u7f13\u6162\u3002\u540c\u65f6\uff0c\u7ec6\u80de\u7597\u6cd5\u5df2\u8d85\u8fc7\u80bf\u7624\u75ab\u82d7\uff0c\u6210\u4e3a\u6700\u5927\u7684\u80bf\u7624\u514d\u75ab\u6cd5\uff0c\u5728\u7814\u9879\u76ee\u6570\u8fbe\u5230864\u4e2a\uff0c\u5360\u6240\u6709\u80bf\u7624\u514d\u75ab\u9879\u76ee\u768425\uff05\u3002\u6b64\u5916\uff0c\u4e34\u5e8a\u524d\u836f\u7269\u589e\u52a097\uff05\uff081067 vs 2107\uff09\uff0c\u4e34\u5e8a\u9636\u6bb5\u836f\u7269\u589e\u957f34\uff05\uff08964 vs 1287\uff09\uff0c\u8868\u660e\u57fa\u7840\u548c\u4e34\u5e8a\u524d\u521b\u65b0\u7814\u7a76\u4e0d\u65ad\u589e\u52a0\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/4-1544151755.jpg\" alt=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\" title=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: center;\">\u56fe1 \u514d\u75ab\u7597\u6cd5\u9879\u76ee\u8d8b\u52bf\uff08\u622a\u6b622018\u5e749\u6708\uff09<br  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"color: rgb(95, 156, 239);font-size: 16px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u8d8b\u52bf\u4e8c\uff1a417\u4e2a\u9776\u70b9\uff0c\u9776\u70b9\u66f4\u591a\uff0c\u7814\u53d1\u96c6\u4e2d\u5ea6\u6709\u6240\u964d\u4f4e<\/strong><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u76ee\u524d\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9879\u76ee\u4e2d\u6709417\u4e2a\u9776\u70b9\u3002\u8fc7\u53bb\u4e00\u5e74\uff0c\u514d\u75ab\u6cbb\u7597\u9776\u70b9\u6570\u589e\u52a050\uff05\uff08\u9644\u8868\uff09\u3002\u6709\u8da3\u7684\u662f\uff0c2017\u5e74\u4e00\u534a\u7684\u7814\u53d1\u9879\u76ee\u96c6\u4e2d\u5728\u524d23\u4e2a\u9776\u70b9\uff0c\u4f462018\u5e74\uff0c\u4e00\u534a\u7684\u7814\u53d1\u9879\u76ee\u96c6\u4e2d\u5728\u524d48\u4e2a\u70ed\u95e8\u9776\u70b9\uff08\u9644\u8868\uff09\u3002\u901a\u5e38\uff0c\u4e00\u4e2a\u9776\u70b9\u6709\u836f\u7269\u83b7\u6279\uff0c\u76f8\u5e94\u7684\u7814\u53d1\u9879\u76ee\u6570\u5c06\u4f1a\u51cf\u5c11\uff08\u56fe2\uff09\u3002\u4f8b\u5982\uff0c\u5c3d\u7ba12018\u5e74\u7ec6\u80de\u7597\u6cd5\u6570\u91cf\u589e\u52a0\u4e86113\uff05\uff0c\u4f46CD19\u9776\u5411\u7ec6\u80de\u7597\u6cd5\u4ec5\u589e\u52a0\u4e8637\uff05\u3002\u76f8\u53cd\uff0c\u9776\u5411\u65b0\u6297\u539f\u7684\u836f\u7269\uff08\u901a\u8fc7\u4e2a\u4f53\u60a3\u8005\u80bf\u7624\u7684\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u786e\u5b9a\u7684\u9776\u6807\uff09\u7684\u5728\u7814\u6570\u91cf\u57281\u5e74\u5185\u589e\u52a0\u4e86133\uff05\u3002\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9776\u70b9\u6570\u91cf\u7684\u589e\u52a0\u53ef\u80fd\u5bfc\u81f4\u672a\u6765\u66f4\u591a\u514d\u75ab\u7597\u6cd5\u83b7\u6279\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u975e\u7279\u5f02\u6027\u80bf\u7624\u76f8\u5173\u6297\u539f\uff08TAA\uff09\u836f\u7269\u5b9e\u9645\u6570\u91cf\u662f\u51cf\u5c11\u7684\uff0c\u8fd9\u8868\u660e\u8be5\u9886\u57df\u6b63\u671d\u7740\u66f4\u7cbe\u786e\u7684\u65b9\u5411\u53d1\u5c55\uff08\u56fe3\uff09\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/10-1544151755.jpg\" alt=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\" title=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: center;\">\u56fe2 \u514d\u75ab\u7597\u6cd5top15\u9776\u70b9<br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/10-1544151756.png\" alt=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\" title=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: center;\">&nbsp; &nbsp; &nbsp; &nbsp;<span style=\"text-align: center;\">\u56fe3 \u975e\u7279\u5f02\u6027\u80bf\u7624\u76f8\u5173\u6297\u539f\u9879\u76ee\u8d8b\u52bf<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"color: rgb(95, 156, 239);font-size: 16px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u8d8b\u52bf\u4e09\uff1a\u66f4\u591a\u7ec4\u7ec7\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u836f\u7269\u8fdb\u5165\u5f00\u53d1<\/strong><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">2017\u5e749\u6708\uff0c461\u4e2a\u7ec4\u7ec7\uff08\u5305\u62ec\u836f\u4f01\u548c\u673a\u6784\uff09\u7684964\u4e2a\u80bf\u7624\u514d\u75ab\u836f\u7269\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\uff08\u542b\u5df2\u5b8c\u6210\u4e34\u5e8a\uff09\uff1b\u4e00\u5e74\u540e\uff0c655\u4e2a\u7ec4\u7ec7\u5728\u8fdb\u884c1287\u4e2a\u4e34\u5e8a\u836f\u7269\u5f00\u53d1\uff0c\u610f\u5473\u7740\u4e34\u5e8a\u9636\u6bb5\u836f\u7269\u6570\u91cf\u589e\u52a034\uff05\u60c5\u51b5\u4e0b\uff0c\u6b63\u5728\u5f00\u5c55\u836f\u7269\u4e34\u5e8a\u5f00\u53d1\u7684\u4f01\u4e1a\u4e0e\u673a\u6784\u6570\u589e\u52a042\uff05\uff08\u56fe4\uff09\u3002\u5bf9\u7167\u4e34\u5e8a\u9879\u76ee\u6392\u540d\u524d15\u7684\u4f01\u4e1a\u673a\u6784\uff0c\u53d1\u73b01\u5e74\u5185\u65b0\u589e36\u79cd\u65b0\u836f\uff0c\u589e\u52a020\uff05\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0cBig Pharma\u4ecd\u5360\u636e\u7740\u4e34\u5e8a\u9879\u76ee\u7684\u4e3b\u5bfc\u5730\u4f4d\uff0c\u9879\u76ee\u6570\u524d8\u4f4d\u5747\u7531\u5176\u4e3b\u5bfc\u30024\u4e2a\u79d1\u7814\u673a\u6784\u8fdb\u5165\u4e34\u5e8a\u9879\u76ee\u6392\u540d\u524d15\uff0c\u5176\u4e2d\u4e09\u5bb6\u662f\u4e2d\u56fd\u673a\u6784\uff0c\u5206\u522b\u662f\u5206\u522b\u4e3a\u6df1\u5733\u5e02\u514d\u75ab\u57fa\u56e0\u6cbb\u7597\u7814\u7a76\u9662\u3001301\u533b\u9662\u548c\u7b2c\u4e09\u519b\u533b\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\uff0c<span style=\"color: rgb(0, 128, 255);\"><strong>\u4e2d\u56fd\u673a\u6784\u8868\u73b0\u4e0d\u4fd7\uff0c\u5f97\u76ca\u4e8e\u56fd\u5185\u7ec6\u80de\u6cbb\u7597\u84ec\u52c3\u53d1\u5c55\u3010\u8bd1\u8005\u6ce8\u3011\u3002<\/strong><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/9-1544151756.jpg\" alt=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\" title=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;text-align: center;\">\u56fe4 Top15\u514d\u75ab\u7597\u6cd5\u4f01\u4e1a\u4e0e\u673a\u6784<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u901a\u8fc7\u65b0\u7684\u8c03\u67e5\u5206\u6790\uff0c\u57281\u5e74\u5185\uff0c\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5168\u7403\u9879\u76ee\u6570\u91cf\u589e\u52a0\u4e8667\uff05\uff0c\u9776\u70b9\u589e\u52a0\u4e8650\uff05\uff0c\u6b63\u5728\u5f00\u5c55\u836f\u7269\u4e34\u5e8a\u5f00\u53d1\u7684\u4f01\u4e1a\u4e0e\u673a\u6784\u6570\u589e\u52a042%\u3002\u8fd9\u79cd\u5de8\u5927\u7684\u589e\u957f\u8868\u660e\u4e86\u6211\u4eec\u5bf9\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u836f\u7269\u5f00\u53d1\u7684\u5f3a\u70c8\u70ed\u60c5\u548c\u4fe1\u5fc3\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7814\u7a76\u5c0f\u7ec4\u8ba4\u4e3a\u8fd9\u79cd\u4e50\u89c2\u6001\u5ea6\u662f\u5408\u7406\u7684\u3002\u9996\u5148\uff0c\u81ea\u524d\u4e00\u6b21\u8c03\u67e5\u4ee5\u6765\uff082017\u5e74\uff09\uff0c\u4e00\u5e74\u5185\u5171\u670910\u4e2a\u9879\u76ee\u83b7\u5f97FDA\u6279\u51c6\uff0c\u5305\u542b\u4e24\u9879CART\u7597\u6cd5\uff0c8\u9879PD1\u548cPDL1\u6297\u4f53\u836f\u7269\uff0c\u4ee5\u53ca\u4e00\u9879CD3\u9776\u5411\u53cc\u7279\u5f02\u6027\u6297\u4f53\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5176\u6b21\uff0c\u81ea2011\u5e74\u4ee5\u6765\uff0c\u65b0\u7684\u514d\u75ab\u7597\u6cd5\u4e0d\u4ec5\u6210\u4e3a15\u79cd\u764c\u75c7\u7c7b\u578b\u7684\u6807\u51c6\u7597\u6cd5\uff0c\u4e5f\u6210\u4e3a\u9ed1\u7d20\u7624\uff0c\u80ba\u764c\u548c\u80be\u764c\u7684\u4e00\u7ebf\u7597\u6cd5\uff0c\u514d\u75ab\u7597\u6cd5\u6210\u4e3a\u764c\u75c7\u6cbb\u7597\u7684\u652f\u67f1\u4e4b\u4e00\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7b2c\u4e09\uff0c\u514d\u75ab\u7597\u6cd5\uff0c\u5982\u6297PD1\u548c\u6297PDL1\u5242\uff0c\u4e5f\u6b63\u8fc5\u901f\u8fdb\u5165\u7f8e\u56fd\uff0c\u6b27\u6d32\u548c\u65e5\u672c\u4ee5\u5916\u7684\u4e3b\u8981\u5e02\u573a\uff0c\u4f8b\u5982\uff0c\u4e2d\u56fd\u6700\u8fd1\u6279\u51c6\u4e86nivolumab\u548cpembrolizumab\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6700\u540e\uff0c\u5927\u91cf\u4e34\u5e8a\u7814\u7a76\u8bc1\u660e\uff0c\u514d\u75ab\u7597\u6cd5\u4e3a\u60a3\u8005\u5e26\u6765\u4e86\u6301\u4e45\u7684\u751f\u5b58\u76ca\u5904\uff0c\u5b9e\u73b0\u4e86\u67d0\u4e9b\u764c\u75c7\u60a3\u8005\u6cbb\u6108\u7684\u5e0c\u671b\u3002\u4f46\uff0c\u6211\u4eec\u5728\u5c06\u6f5c\u5728\u764c\u75c7\u514d\u75ab\u5b66\u6210\u529f\u8f6c\u5316\u4e3a\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u65f6\u9700\u8981\u8c28\u614e\u3002\u6700\u8fd1\u8bc4\u4f30\u5432\u54da\u80fa2,3-\u53cc\u52a0\u6c27\u91761\uff08IDO1\uff09\u6291\u5236\u5242\u7684\u591a\u9879III\u671f\u7814\u7a76\u7684\u5931\u8d25\u6216\u7ec8\u6b62\uff0c\u63d0\u9192\u6211\u4eec\uff0c\u836f\u7269\u5f00\u53d1\u662f\u4e00\u9879\u975e\u5e38\u5192\u9669\u7684\u5c1d\u8bd5\u3002\u5c55\u671b\u672a\u6765\uff0c\u79d1\u5b66\u8bc1\u636e\u5e94\u8be5\u4e3b\u5bfc\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u836f\u7269\u5f00\u53d1\u3002\u4f8b\u5982\uff0c\u6240\u6709\u7b26\u5408\u6761\u4ef6\u7684\u764c\u75c7\u8bd5\u9a8c\u90fd\u5e94\u91c7\u7528\u751f\u7269\u6807\u5fd7\u7269\u6765\u7b5b\u9009\u90a3\u4e9b\u6700\u6709\u53ef\u80fd\u4ece\u6b63\u786e\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u4e2d\u83b7\u76ca\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u76f8\u5173\u7814\u7a76\u5e94\u6700\u5927\u7a0b\u5ea6\u5730\u6574\u5408\u5230\u6240\u6709\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u4ee5\u4fbf\u6211\u4eec\u53ef\u4ee5\u4ece\u6210\u529f\u548c\u5931\u8d25\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5b66\u4e60\uff0c\u8fd9\u5c06\u4f7f\u6bcf\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u548c\u6bcf\u4e2a\u60a3\u8005\u5fd7\u613f\u8005\u4e3a\u6211\u4eec\u8ffd\u6c42\u6cbb\u7597\u764c\u75c7\u505a\u51fa\u66f4\u591a\u8d21\u732e\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 16px;color: rgb(95, 156, 239);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u9644\u8868\uff1a\u5728\u7814\u7ba1\u7ebf\u9776\u70b9\u7edf\u8ba1<\/strong><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n<p><img class=\"\"       style=\"float: left;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/2-1544151757.jpg\" alt=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\" title=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\"  \/><\/p>\n<p><img class=\"\"       style=\"float: left;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/5-1544151757.jpg\" alt=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\" title=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\"  \/><\/p>\n<p><img class=\"\"       style=\"float: left;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/3-1544151758.jpg\" alt=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\" title=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\"  \/><\/p>\n<p><img class=\"\"       style=\"float: left;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/5-1544151759.jpg\" alt=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\" title=\"Nature\u836f\u7269\u7efc\u8ff0:\u300a\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\u300b\uff0c\u56f4\u7ed5417\u4e2a\u9776\u70b9\uff0c3394\u4e2a\u9879\u76ee\u5728\u5f00\u5c55\uff08\u542b\u5df2\u4e0a\u5e02\uff09\"  \/><\/p>\n<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;background-position: 0% 0%;background-repeat: repeat;background-size: auto;background-attachment: scroll;border-style: solid;border-width: 1px;border-radius: 6px;border-color: rgb(62, 62, 62);overflow: hidden;background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/9-1544151759.png');box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-right: 0%;margin-bottom: -2px;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;background-color: rgb(255, 255, 255);padding: 5px;border-style: none none solid;border-width: 1px;border-radius: 6px;border-color: rgb(62, 62, 62);overflow: hidden;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;background-color: rgb(216, 98, 34);border-width: 0px;border-radius: 6px;border-style: none;border-color: rgb(62, 62, 62);overflow: hidden;padding: 5px 10px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: left;color: rgb(252, 242, 241);padding-right: 10px;padding-left: 10px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u4f5c\u8005\u7b80\u4ecb<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u60df\u533b\uff0c\u533b\u836f\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5173\u6ce8\u533b\u836f\u653f\u7b56\u3001\u4f01\u4e1a\u548c\u4ea7\u54c1\u52a8\u6001\uff0c\u628a\u63e1\u8d8b\u52bf\uff0c\u53d1\u73b0\u4ef7\u503c\u3002\u64c5\u957f\u836f\u7269\u9012\u9001\u9879\u76ee\u8bc4\u4f30\uff0c\u5df2\u53d1\u8868\u591a\u7bc7\u76f8\u5173\u6587\u7ae0\u3002<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\"><br  \/><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u8f6c\u81ea\uff1aCPhI\u5236\u836f\u5728\u7ebf 10\u670819\u65e5\uff0c\u7ebd\u7ea6\u764c\u75c7\u7814\u7a76\u6240\uff08CRI\uff0cCancer Research Institut [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":60897,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60896"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=60896"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60896\/revisions"}],"predecessor-version":[{"id":60907,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60896\/revisions\/60907"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/60897"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=60896"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=60896"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=60896"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}