{"id":60917,"date":"2018-11-11T01:00:00","date_gmt":"2018-12-07T03:02:50","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/d3958e1850\/"},"modified":"2018-12-07T11:02:53","modified_gmt":"2018-12-07T03:02:53","slug":"d3958e1850","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/60917\/","title":{"rendered":"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c39\u671f\uff09"},"content":{"rendered":"
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\u56fd\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/section>\n<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n

1. \u65b0\u57fa\u516c\u53f8\uff08Celgene\uff09\u5728\u7f8e\u56fd\u8840\u6db2\u534f\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u65b0\u836fRevlimid\uff08lenalidomide\uff0c\u6765\u90a3\u5ea6\u80fa\uff09\u57283\u671f\u4e34\u5e8a\u8bd5\u9a8cAUGMENT\u4e2d\u7684\u79ef\u6781\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u663e\u793a\uff0cRevlimid\u4e0e\u7f57\u6c0f\uff08Roche\uff09\u7684Rituxan\uff08rituximab\uff0c\u5229\u59a5\u6614\u5355\u6297\uff09\u8054\u5408\uff08\u7b80\u79f0R2\uff09\uff0c\u5728\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff08FL\uff09\u548c\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08MZL\uff09\u60a3\u8005\u7684\u4e8c\u7ebf\u6cbb\u7597\u4e2d\uff0c\u4e0e\u5355\u7528Rituxan\u76f8\u6bd4\u5177\u6709\u663e\u8457\u4f18\u52bf\u3002<\/span>
<\/p>\n

2. \u4e13\u6ce8\u4e8e\u5f00\u53d1\u521b\u65b0\u764c\u75c7\u7597\u6cd5\u548c\u836f\u7269\u9012\u9001\u6280\u672f\u7684\u751f\u7269\u6280\u672f\u516c\u53f8Halozyme Therapeutics\u5ba3\u5e03\u4e0e\u7f57\u6c0f\uff08Roche\uff09\u8fbe\u6210\u4e86\u4e00\u9879\u6388\u6743\u534f\u8bae\u3002Halozyme\u5c06\u6388\u6743\u7f57\u6c0f\u4f7f\u7528\u5176ENHANZE\u836f\u7269\u9012\u9001\u6280\u672f\uff0c\u72ec\u5bb6\u5f00\u53d1\u4e00\u79cd\u65b0\u7684\u3001\u5c1a\u672a\u516c\u5f00\u7684\u4e34\u5e8a\u9636\u6bb5\u7597\u6cd5\u3002\u7f57\u6c0f\u53ef\u9009\u62e9\u5728\u672a\u67654\u5e74\u4e4b\u5185\u518d\u6dfb\u52a0\u4e24\u4e2a\u7597\u6cd5\u76ee\u6807\u3002\u4f9d\u636e\u534f\u8bae\uff0cHalozyme\u5c06\u83b7\u5f972500\u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u5e76\u5c06\u5bf9\u6bcf\u4e2a\u7597\u6cd5\u76ee\u6807\u53ef\u5f97\u5230\u6700\u9ad8\u91d1\u989d\u4e3a1.65\u4ebf\u7f8e\u5143\u7684\u672a\u6765\u91cc\u7a0b\u7891\u548c\u9500\u552e\u5206\u6210\u4ed8\u6b3e\u3002<\/span><\/p>\n

3. \u65e5\u524d\uff0c\u7f8e\u56fdFDA\u6279\u51c6\u8f89\u745e\u7814\u53d1\u7684\u7b2c\u4e09\u4ee3ALK\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09Lorbrena\uff08lorlatinib\uff09\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597ALK\u9633\u6027\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u3002\u8fd9\u4e9b\u60a3\u8005\u5728\u63a5\u53d7crizotinib\u6216\u8005\u81f3\u5c11\u4e00\u79cd\u5176\u5b83ALK\u6291\u5236\u5242\u6cbb\u7597\u540e\u75be\u75c5\u7ee7\u7eed\u6076\u5316\uff0c\u6216\u8005\u63a5\u53d7alectinib\u6216ceritinib\u4f5c\u4e3a\u7b2c\u4e00\u79cdALK\u6291\u5236\u5242\u7597\u6cd5\u540e\u75be\u75c5\u7ee7\u7eed\u6076\u5316\u3002\u8fd9\u662f\u8f89\u745e\u516c\u53f8\u5728\u6700\u8fd1\u4e24\u4e2a\u6708\u5185\u83b7\u5f97FDA\u6279\u51c6\u7684\u7b2c\u4e09\u9879\u80bf\u7624\u7597\u6cd5\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c39\u671f\uff09\"<\/p>\n

\u56fe\uff1aLorbrena<\/strong><\/span><\/p>\n

4. Urovant Sciences\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u7814\u53d1\u7684\u53e3\u670d\u03b2-3\u80be\u4e0a\u817a\u7d20\u53d7\u4f53\u6fc0\u52a8\u5242vibegron\uff0c\u5728\u6cbb\u7597\u8180\u80f1\u8fc7\u5ea6\u6d3b\u52a8\u75c7\uff08OAB\uff09\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u83b7\u5f97\u79ef\u6781\u7ed3\u679c\u3002\u8fd9\u9879\u7814\u7a76\u7ed3\u679c\u540c\u65f6\u5728\u300aEuropean Urology\u300b\u6742\u5fd7\u4e0a\u83b7\u5f97\u53d1\u8868\u3002<\/span><\/p>\n

5. \u8fd1\u65e5\uff0cFDA\u6279\u51c6\u4e86AcelRx\u516c\u53f8\u7684\u963f\u7247\u7c7b\u836f\u7269Dsuvia\uff0c\u9002\u7528\u4e8e\u5728\u7ecf\u8ba4\u8bc1\u7684\u533b\u7597\u76d1\u7763\u533b\u7597\u673a\u6784\u5185\uff08\u5982\u533b\u9662\u3001\u5916\u79d1\u4e2d\u5fc3\u548c\u6025\u8bca\u79d1\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u5176\u4ed6\u66ff\u4ee3\u6cbb\u7597\u6548\u679c\u4e0d\u7406\u60f3\u7684\uff0c\u4e25\u91cd\u5230\u9700\u8981\u4f7f\u7528\u963f\u7247\u7c7b\u9547\u75db\u836f\u7684\u6025\u6027\u75bc\u75db\u3002Dsuvia\u662f\u4e00\u79cd\u820c\u4e0b\u542b\u7247\uff0c\u542b\u670930\u5fae\u514b\u7684\u6d3b\u6027\u836f\u7269\u6210\u5206sufentanil\uff08\u8212\u82ac\u592a\u5c3c\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u963f\u7247\u7c7b\u836f\u7269\uff0c\u901a\u8fc7\u4f5c\u7528\u4e8e\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u5185\u7684\u03bc\u963f\u7247\u53d7\u4f53\u4ea7\u751f\u9547\u75db\u4f5c\u7528\uff0c\u51cf\u8f7b\u75bc\u75db\u53cd\u5e94\u3002<\/span><\/p>\n

6. \u5b89\u65af\u6cf0\u6765\u65b0\u578b\u8d2b\u8840\u836f\u7269roxadustat\uff08\u7f57\u6c99\u53f8\u4ed6\uff092\u4e2a\u65e5\u672cIII\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u79ef\u6781\u6570\u636e\u3002Roxadustat\u662f\u4e00\u79cd\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u812f\u6c28\u9170\u7f9f\u5316\u9176\uff08HIF-PH\uff09\u6291\u5236\u5242\uff0c\u53ef\u6291\u5236HIF\u7684\u6cdb\u7d20\u5316\u964d\u89e3\uff0c\u5e2e\u52a9\u673a\u4f53\u4ea7\u751f\u66f4\u591a\u7684\u7ea2\u8840\u7403\u3002\u8be5\u836f\u5df2\u5728\u4e2d\u56fd\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\uff0c\u5e76\u5df2\u88abCDE\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002<\/span><\/p>\n

7. \u827e\u4f2f\u7ef4\uff08AbbVie\uff09\u4e0e\u7f57\u6c0f\uff08Roche\uff09\u8fd1\u65e5\u8054\u5408\u5ba3\u5e03\u8bc4\u4f30Venclexta\/Venclyxto\uff08venetoclax\uff09\u4e0eGazyva\/Gazyvaro\uff08obinutuzumab\uff09\u7ec4\u5408\u7597\u6cd5\u4e00\u7ebf\u6cbb\u7597\u4f34\u5408\u5e76\u75c7\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u7814\u7a76CLL14\u83b7\u5f97\u4e86\u79ef\u6781\u7ed3\u679c\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c39\u671f\uff09\"<\/p>\n

8. \u4e13\u79d1\u836f\u5f00\u53d1\u5546Aquestive Therapeutics\u8fd1\u65e5\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u5df2\u6279\u51c6Sympazan\uff08clobazam\uff0c\u6c2f\u5df4\u5360\uff09\u53e3\u8154\u819c\uff0c\u7528\u4e8e2\u5c81\u53ca\u4ee5\u4e0a\u60a3\u8005\u6cbb\u7597Lennox-Gastaut\u7efc\u5408\u5f81\uff08LGS\uff09\u76f8\u5173\u7684\u766b\u75eb\u53d1\u4f5c\u3002\u8be5\u516c\u53f8\u5df2\u8ba1\u5212\u4e8e\u8fd1\u671f\u5c06Sympazan\u63a8\u5411\u5e02\u573a\u3002\u6b64\u6b21\u6279\u51c6\uff0c\u4f7fSympazan\u6210\u4e3a\u9996\u4e2a\u4e5f\u662f\u552f\u4e00\u4e00\u4e2a\u83b7FDA\u6279\u51c6\u6cbb\u7597LGS\u76f8\u5173\u766b\u75eb\u53d1\u4f5c\u7684\u53e3\u8154\u819c\u5242\u3002\u4e4b\u524d\uff0c\u6c2f\u5df4\u5360\u5df2\u4ee5\u54c1\u724c\u540dOnfi\u4e0a\u5e02\uff0c\u5e76\u53ef\u63d0\u4f9b\u53e3\u670d\u7247\u5242\u548c\u53e3\u670d\u6df7\u60ac\u6db22\u79cd\u5242\u578b\u3002<\/span><\/p>\n

9. \u8fd1\u65e5\uff0cAlkermes\u7684\u91cd\u5ea6\u6291\u90c1\u75c7\uff08MDD\uff09\u65b0\u836fALKS5461\u5728\u7f8e\u56fd\u76d1\u7ba1\u65b9\u9762\u4f20\u6765\u4e0d\u5229\u6d88\u606f\u3002\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u7cbe\u795e\u836f\u7406\u5b66\u836f\u7269\u54a8\u8be2\u59d4\u5458\u4f1a\uff08PDAC\uff09\u53ca\u836f\u7269\u5b89\u5168\u548c\u98ce\u9669\u7ba1\u7406\u54a8\u8be2\u59d4\u5458\u4f1a\uff08DSaRM\uff09\u5df2\u53ec\u5f00\u4f1a\u8bae\u5bf9ALKS5461\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\u8fdb\u884c\u4e86\u5ba1\u67e5\u53ca\u8054\u5408\u8868\u51b3\uff0c\u4ee52\u7968\u8d5e\u6210\u300121\u7968\u53cd\u5bf9\u7684\u610f\u89c1\u8ba4\u4e3aALKS5461\u7684\u6548\u76ca\u98ce\u9669\u6570\u636e\u4e0d\u8db3\u4ee5\u652f\u6301\u8be5\u836f\u7684\u6279\u51c6\u3002<\/span><\/p>\n

10. Zion Medical\u662f\u4e00\u5bb6\u4ee5\u8272\u5217\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u6cbb\u7597\u827e\u6ecb\u75c5\u548c\u764c\u75c7\u7684\u521b\u65b0\u7597\u6cd5\u3002\u8fd1\u65e5\uff0c\u8be5\u516c\u53f8\u516c\u5e03\u4e86\u5b9e\u9a8c\u6027HIV\u836f\u7269Gammora\u7684\u9996\u6279\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u3002\u6570\u636e\u663e\u793a\uff0c\u8be5\u836f\u5728\u6cbb\u75974\u5468\u5185\u6e05\u9664\u4e86\u60a3\u8005\u4f53\u5185\u591a\u8fbe99%\u7684HIV\u75c5\u6bd2\u3002<\/span><\/p>\n

11. \u6cd5\u56fd\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u79d1\u6280\u516c\u53f8Onxeo\u8868\u793a\uff0c\u516c\u53f8\u5168\u7403\u9996\u521b\uff08first-in-class\uff09DNA\u635f\u4f24\u5e94\u7b54\u6291\u5236\u5242AsiDNA\u2122\u7684\u4e34\u5e8a1\u671f\u7814\u7a76DRIIV-1\u516c\u5e03\u6700\u65b0\u7ed3\u679c\u3002\u5728\u8be5\u7814\u7a76\u7684\u516d\u79cd\u5242\u91cf\u6c34\u5e73\u4e2d\uff0c\u5df2\u6709\u4e09\u79cd\u5242\u91cf\u6c34\u5e73\u5f97\u5230\u4e86\u521d\u6b65\u8bc4\u4f30\uff0c\u5e76\u4e14\u83b7\u5f97\u4e86\u79ef\u6781\u7684\u4e2d\u671f\u7ed3\u679c\u3002<\/span><\/p>\n

12. AVEO Oncology\u516c\u53f8\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u7684tivozanib\u5728\u6cbb\u7597\u9ad8\u5ea6\u96be\u6cbb\u6027\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u7684\u5173\u952e\u60273\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fbe\u5230\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\uff0c\u4e0e\u73b0\u6709\u6807\u51c6\u7597\u6cd5\u76f8\u6bd4\u663e\u8457\u6539\u5584\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002<\/span><\/p>\n

13. \u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u6280\u672f\u516c\u53f8Sorrento Therapeutics\u516c\u5e03\u79f0\uff0c\u5176\u5229\u7528TriSalus\u2122\u751f\u547d\u79d1\u5b66\u516c\u53f8Pressure-enabled Drug Delivery\u2122\uff08PEDD\uff09\u6280\u672f\u751f\u4ea7\u7684\u6297CEA CAR-T\u7597\u6cd5\u4e34\u5e8a1b\u8bd5\u9a8c\u83b7\u5f97\u4e86\u79ef\u6781\u6570\u636e\u3002\u4e34\u5e8a\u8bd5\u9a8c\u7684\u521d\u6b65\u6570\u636e\u5c06\u572811\u67087-11\u65e5\u4e3e\u884c\u7684\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u5b66\u4f1a\u5e74\u4f1a\uff08SITC\uff09\u4e0a\u5c55\u793a\u3002<\/span><\/p>\n

14. \u5409\u5229\u5fb7\u8fd1\u65e5\u5ba3\u5e03\uff0c\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6279\u51c6\u4e24\u6b3eHIV\u836f\u7269Odefsey\u548cComplera\u6807\u7b7e\u66f4\u65b0\uff0c\u7eb3\u5165\u5728\u611f\u67d3HIV-1\u7684\u5b55\u5987\u4e2d\u7684\u5b89\u5168\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u6570\u636e\u3002\u8fd9\u4e5f\u662f\u7ee7\u4eca\u5e742\u6708Edurant\u6807\u7b7e\u66f4\u65b0\u540e\uff0c\u53e6\u4e24\u6b3e\u542b\u5229\u5339\u97e6\u6797HIV\u836f\u7269\u6807\u7b7e\u66f4\u65b0\u3002<\/span><\/p>\n

15. \u65e5\u672c\u5236\u836f\u5de8\u5934\u6b66\u7530\uff08Takeda\uff09\u8fd1\u65e5\u5ba3\u5e03\u5df2\u5728\u65e5\u672c\u5e02\u573a\u63a8\u51faEntyvio\uff08vedolizumab\uff09\uff0c\u7528\u4e8e\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u6d3b\u52a8\u6027\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\uff08UC\uff09\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

16. Enyo Pharma\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u6cbb\u7597\u809d\u810f\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u3002\u8fd1\u65e5\uff0c\u8be5\u516c\u53f8\u5ba3\u5e03\u5df2\u6210\u529f\u5b8c\u6210\u5b9e\u9a8c\u6027FXR\u6fc0\u52a8\u5242EYP001\u6cbb\u7597\u6162\u6027\u4e59\u578b\u809d\u708e\uff08CHBV\uff0c\u4e59\u809d\uff09\u7684Ib\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u8be5\u516c\u53f8\u5df2\u8ba1\u5212\u57282019\u5e74\u7b2c\u4e00\u5b63\u5ea6\u542f\u52a8EYP001\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u548c\u4e59\u809d\u76842\u4e2aII\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/span><\/p>\n

17. \u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u4e0e\u5408\u4f5c\u4f19\u4f34\u827e\u4f2f\u7ef4\uff08AbbVie\uff09\u8fd1\u65e5\u8054\u5408\u5ba3\u5e03\uff0c\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6279\u51c6\u514d\u75ab\u523a\u6fc0\u7597\u6cd5Empliciti\uff08elotuzumab\uff09\u8054\u5408Pomalyst\uff08pomalidomide\uff0c\u6cca\u9a6c\u5ea6\u80fa\uff09\u53ca\u4f4e\u5242\u91cf\u5730\u585e\u7c73\u677e\u65b9\u6848\uff08EPd\uff09\uff0c\u7528\u4e8e\u5148\u524d\u5df2\u63a5\u53d7\u81f3\u5c112\u79cd\u7597\u6cd5\uff08\u5305\u62ec\u6765\u90a3\u5ea6\u80fa[lenalidomide]\u548c\u4e00\u79cd\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242[PI]\uff09\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u6210\u4eba\u60a3\u8005\u3002\u4e4b\u524d\uff0cFDA\u5df2\u6388\u4e88\u8be5\u4e09\u836f\u65b9\u6848EPd\u7684\u4f18\u5148\u5ba1\u67e5\u8d44\u683c\u3002<\/span><\/p>\n

18. \u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5de8\u5934\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u4e0eInfinity\u5236\u836f\u516c\u53f8\u8fd1\u65e5\u5ba3\u5e03\uff0c\u53cc\u65b9\u5df2\u8fbe\u6210\u4e00\u9879\u4e34\u5e8a\u7814\u7a76\u5408\u4f5c\uff0c\u8bc4\u4f30PD-1\u80bf\u7624\u514d\u75ab\u7597\u6cd5Opdivo\uff08\u4e2d\u6587\u5546\u54c1\u540d\uff1a\u6b27\u72c4\u6c83\uff0c\u901a\u7528\u540d\uff1a\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff0cnivolumab\uff09\u8054\u5408Infinity\u516c\u53f8\u7684IPI-549\u7528\u4e8e\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\uff08UC\uff09\u60a3\u8005\u7684\u6cbb\u7597\u3002IPI-549\u662f\u4e00\u79cd\u53e3\u670d\u514d\u75ab\u80bf\u7624\u5b66\u836f\u7269\uff0c\u65e8\u5728\u9009\u62e9\u6027\u5730\u6291\u5236\u78f7\u8102\u9170\u808c\u9187-3-\u6fc0\u9176\uff08PI3K\uff09-\u03b3\uff0c\u8be5\u836f\u4e5f\u662f\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684\u552f\u4e00\u4e00\u4e2aPI3K-\u03b3\u6291\u5236\u5242\u3002<\/span><\/p>\n

19. \u65e5\u524d\uff0c\u793c\u6765\u516c\u53f8\u7ec8\u6b62\u4e86\u4e00\u9879\u6b63\u5728\u8fdb\u884c\u963f\u5c14\u8328\u6d77\u9ed8\u6cbb\u7597\u7684BACE\u6291\u5236\u5242\u4e34\u5e8a\u7814\u7a76\uff0c\u8be5\u7814\u7a76\u5c06BACE\u6291\u5236\u5242\u4e0e\u80fd\u591f\u548c\u5927\u8111\u6dc0\u7c89\u6837\u6c89\u79ef\u7269\u7ed3\u5408\u7684\u5355\u514b\u9686\u6297\u4f53\u8054\u7528\uff0c\u8bc4\u4f30\u6cbb\u7597\u6548\u679c\u3002\u793c\u6765\u6ca1\u6709\u516c\u5e03\u5177\u4f53\u7ec6\u8282\uff0c\u4ec5\u6307\u51fa\u836f\u7269\u4e3aLY3202626\uff08BACE IV\uff09\uff0c\u5355\u514b\u9686\u6297\u4f53\u836f\u7269\u4e3aLY3002813\uff08N3pG mAb\uff09\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c39\u671f\uff09\"<\/p>\n

20. Bausch Health\u516c\u53f8\u53ca\u65d7\u4e0b\u76ae\u80a4\u79d1\u516c\u53f8Ortho Dermatologics\u8fd1\u65e5\u5ba3\u5e03\uff0c\u5728\u7f8e\u56fd\u63a8\u51faBryhali\uff08halobetasol propionate\uff0c\u5364\u500d\u4ed6\u7d22\u4e19\u9178\u916f\uff0c0.01%\uff09\u4e73\u6db2\uff0c\u8be5\u836f\u662f\u4e00\u79cd\u5c40\u90e8\u6cbb\u7597\u836f\u7269\uff0c\u7528\u4e8e\u6210\u4eba\u60a3\u8005\u6591\u5757\u578b\u94f6\u5c51\u75c5\u7684\u6cbb\u7597\u3002Bryhali\u4e8e2018\u5e7410\u670812\u65e5\u83b7\u5f97\u7f8e\u56fdFDA\u4e34\u65f6\u6279\u51c6\uff0c\u5e76\u4e8e11\u67086\u65e5\u83b7\u5f97\u6700\u7ec8\u6279\u51c6\u3002<\/span><\/p>\n

21. \u7814\u7a76\u8005\u5728\u4e00\u79cd\u540d\u4e3aezogabine\u7684\u6297\u75c9\u631b\u836f\u7269\u4e2d\u53d1\u73b0\u4e86\u6cbb\u7597\u91cd\u5ea6\u6291\u90c1\u75c7\u7684\u5e0c\u671b\u3002\u8fd1\u65e5\uff0c\u6765\u81ea\u7ebd\u7ea6\u897f\u5948\u5c71\u4f0a\u574e\u533b\u5b66\u9662\u7684\u79d1\u5b66\u5bb6\u5bf918\u540d\u60a3\u6709\u4e25\u91cd\u6291\u90c1\u75c7\u4f46\u6ca1\u6709\u670d\u7528\u4efb\u4f55\u836f\u7269\u7684\u53c2\u4e0e\u8005\u8fdb\u884c\u4e86ezogabine\u7684\u836f\u7269\u6d4b\u8bd5\u3002\u7814\u7a76\u6210\u679c\u76ee\u524d\u53d1\u8868\u572811\u67081\u65e5\u7684\u300a\u5206\u5b50\u7cbe\u795e\u75c5\u5b66\u300b(Molecular Psychiatry)\u6742\u5fd7\u4e0a\u3002<\/span><\/p>\n

22.\u963f\u65af\u5229\u5eb7\u5bf9\u7814\u53d1\u7ba1\u7ebf\u8fdb\u884c\u4e86\u66f4\u65b0\u3002\u66f4\u65b0\u540e\u7684\u7ba1\u7ebf\u663e\u793a\uff0c\u963f\u65af\u5229\u5eb7\u5df2\u7ec8\u6b62\u4e86vistusertib\u4f5c\u4e3a\u5355\u836f\u7597\u6cd5\u6cbb\u7597\u5b9e\u4f53\u80bf\u7624\u4ee5\u53ca\u4e0e\u8be5\u516c\u53f8\u6700\u8fd1\u6279\u51c6\u7684BTK\u6291\u5236\u5242Calquence\uff08acalabrutinib\uff09\u8054\u5408\u7528\u836f\u6cbb\u7597\u8840\u6db2\u764c\u75c7\u7684\u6240\u6709\u7814\u7a76\u3002\u9664\u4e86vistusertib\u4e4b\u5916\uff0c\u8be5\u516c\u53f8\u4e5f\u5df2\u7ec8\u6b62\u4e86\u547c\u5438\u7ec4\u5408\u7597\u6cd5AZD7594\/abediterol\u6cbb\u7597\u54ee\u5598\u548c\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\uff08COPD\uff09\u7684\u4e34\u5e8a\u9879\u76ee\u3002<\/span><\/p>\n

\n
\n
\n
\n
\u56fd\u5185\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/section>\n<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n

1. \u534e\u6d77\u836f\u4e1a\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u516c\u53f8\u8fd1\u65e5\u6536\u5230\u7f8e\u56fdFDA\u5173\u4e8e\u683c\u9686\u6eb4\u94f5\u6ce8\u5c04\u6db2\u7684\u65b0\u836f\u7b80\u7565\u7533\u8bf7(ANDA)\u5df2\u83b7\u5f97\u6279\u51c6\u7684\u901a\u77e5\u3002\u76ee\u524d\u8be5\u4ea7\u54c1\u5c1a\u672a\u5728\u56fd\u5185\u4e0a\u5e02\u9500\u552e\u3002<\/span>
<\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c39\u671f\uff09\"<\/p>\n

2. \u56fd\u5bb6\u836f\u76d1\u5c40\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u4e3a\u8fdb\u4e00\u6b65\u4fdd\u969c\u516c\u4f17\u7528\u836f\u5b89\u5168\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u51b3\u5b9a\u5bf9\u84b2\u5730\u84dd\u6d88\u708e\u7247\uff08\u80f6\u56ca\uff09\u975e\u5904\u65b9\u836f\u8bf4\u660e\u4e66\u8303\u672c\u8fdb\u884c\u4fee\u8ba2\u3002<\/span><\/p>\n

3. \u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u5b98\u7f51\u4e3b\u9875\u70ed\u70b9\u680f\u76ee\u4e2d\uff0c\u51fa\u73b0\u201c\u4e34\u5e8a\u8bd5\u9a8c\u9ed8\u793a\u8bb8\u53ef\u516c\u793a\u201d\u4e00\u680f\uff0c\u8fd9\u610f\u5473\u7740\u4e2d\u56fd\u6b63\u5f0f\u5bf9\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7531\u8fc7\u53bb\u7684\u5ba1\u6279\u5236\u6539\u9769\u4e3a\u9ed8\u793a\u8bb8\u53ef\u3002<\/span><\/p>\n

4. \u6839\u636eCDE\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u4fe1\u606f\u516c\u793a\u5e73\u53f0\u6700\u65b0\u6570\u636e\u663e\u793a\uff0c\u6052\u745e\u65d7\u4e0bCD47\u5355\u6297SHR-1603\u57282018\u5e7411\u67085\u65e5\u516c\u5e03\u4e86\u8bd5\u9a8c\u65b9\u6848\uff0c\u6b63\u5f0f\u6807\u5fd7\u7740\u4e34\u5e8aI\u671f\u8bd5\u9a8c\u7684\u5f00\u5c55\u3002\u6052\u745e\u57282018\u5e742\u6708\u521d\u5bf9\u8be5\u836f\u7533\u62a5\u4e34\u5e8a\uff0c\u4e8e6\u67088\u65e5\u83b7\u5f97\u4e34\u5e8a\u6279\u4ef6\uff0c\u79ef\u6781\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u662f\u770b\u91cdCD47\u9776\u70b9\u7684\u91cd\u5927\u6f5c\u529b\u3002<\/span><\/p>\n

5. 11\u67087\u65e5\uff0c\u4e0a\u6d77\u5e02\u59d4\u529e\u516c\u5385\u3001\u5e02\u653f\u5e9c\u529e\u516c\u5385\u8054\u5408\u5370\u53d1\u4e86\u300a\u5173\u4e8e\u6df1\u5316\u5ba1\u8bc4\u5ba1\u6279\u5236\u5ea6\u6539\u9769\u9f13\u52b1\u836f\u54c1\u533b\u7597\u5668\u68b0\u521b\u65b0\u7684\u5b9e\u65bd\u610f\u89c1\u300b\u3002\u8be5\u300a\u5b9e\u65bd\u610f\u89c1\u300b\u7531\u6539\u9769\u4e34\u5e8a\u8bd5\u9a8c\u7ba1\u7406\u3001\u52a0\u5feb\u836f\u54c1\u533b\u7597\u5668\u68b0\u4e0a\u5e02\u3001\u5efa\u8bbe\u5168\u7403\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u521b\u65b0\u7814\u53d1\u9ad8\u5730\u3001\u52a0\u5f3a\u836f\u54c1\u533b\u7597\u5668\u68b0\u5168\u751f\u547d\u5468\u671f\u7ba1\u7406\u548c\u670d\u52a1\u3001\u63d0\u5347\u6280\u672f\u652f\u6491\u80fd\u529b\u3001\u5f3a\u5316\u4fdd\u969c\u63aa\u65bd\u7b49\u516d\u65b9\u976232\u6761\u6539\u9769\u4efb\u52a1\u6784\u6210\uff0c\u7b80\u79f0\u201c\u9f13\u52b1\u836f\u68b0\u521b\u65b032\u6761\u201d\u3002<\/span><\/p>\n

6. \u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u516c\u5e03\u4e86\u5173\u4e8e\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u81ea\u67e5\u6838\u67e5\u6ce8\u518c\u7533\u8bf7\u60c5\u51b5\u7684\u516c\u544a\uff082018\u5e74\u7b2c86\u53f7\uff09\u3002\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u51b3\u5b9a\u5bf9\u65b0\u6536\u5230\u76847\u4e2a\u5df2\u5b8c\u6210\u4e34\u5e8a\u8bd5\u9a8c\u7533\u62a5\u751f\u4ea7\u7684\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\uff08\u89c1\u9644\u4ef6\uff09\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u6838\u67e5\uff0c\u836f\u7269\u6d89\u53ca\u6c5f\u82cf\u6052\u745e\u533b\u836f\u7684\u76d0\u9178\u827e\u53f8\u6c2f\u80fa\u916e\u6ce8\u5c04\u6db2\u3001\u5357\u4eac\u6d77\u7eb3\u5236\u836f\u7684\u5965\u7f8e\u62c9\u5511\u5e72\u6df7\u60ac\u5242\uff08\u2160\u3001\u2161\uff09\u3001\u5b89\u5fbd\u8d1d\u514b\u751f\u7269\u7684\u4f9d\u975e\u97e6\u4f26\u7247\u4ee5\u53ca\u5170\u5dde\u751f\u7269\u5236\u54c1\u7814\u7a76\u6240\u7684\u6ce8\u5c04\u7528A\u578b\u8089\u6bd2\u6bd2\u7d20\uff0c\u591a\u6570\u7533\u8bf7\u5747\u4e3a\u4eff\u5236\u836f\u3002<\/span><\/p>\n

7. \u4e3a\u6307\u5bfc\u548c\u89c4\u8303\u6297\u7cbe\u795e\u75c5\u836f\u7269\u548c\u53cc\u76f8\u969c\u788d\u6cbb\u7597\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7ec4\u7ec7\u5236\u5b9a\u4e86\u300a\u6297\u7cbe\u795e\u75c5\u836f\u7269\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\u3001\u300a\u53cc\u76f8\u969c\u788d\u6cbb\u7597\u836f\u7269\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c39\u671f\uff09\"<\/p>\n

8. \u4e3d\u73e0\u533b\u836f\u96c6\u56e2\u53d1\u5e03\u516c\u544a\u79f0\u5176\u63a7\u80a1\u5b50\u516c\u53f8\u73e0\u6d77\u5e02\u4e3d\u73e0\u5355\u6297\u751f\u7269\u6280\u672f\u6709\u9650\u516c\u53f8\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6838\u51c6\u7b7e\u53d1\u7684\u91cd\u7ec4\u4eba\u6e90\u5316\u6297\u4eba IL-6R \u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\u300a\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\u300b\uff08\u6279\u4ef6\u53f7\uff1a2018L03177\uff09\u3002<\/span><\/p>\n

9. \u76ee\u524d\u590d\u661f\u51ef\u7279\u4e0e\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u745e\uf90a\u533b\u9662\u3001\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u534f\u548c\u533b\u9662\u548c\u82cf\u5dde\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u6b63\u5f0f\u542f\u52a8\u5173\u4e8e\u201c\u8bc4\u4ef7CAR-T\u4ea7\u54c1FKC876\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u4fb5\u88ad\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u7684\u5f00\u653e\u6027\u4e34\u5e8a\u7814\u7a76\u201d\uff0c\u5f00\u5c55\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n

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\u673a\u5236\u9776\u70b9\u7814\u7a76\u8fdb\u5c55<\/section>\n<\/section>\n
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1. \u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Nature Immunology\u4e0a\u9898\u4e3a\u201cActivated \u03b2-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity\u201d\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u8036\u9c81\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff0c\u9ad8\u76d0\u73af\u5883\u6216\u8bb8\u662f\u8bf1\u53d1\u591a\u53d1\u6027\u786c\u5316\u75c7\uff08MS\uff0cmultiple sclerosis\uff09\u7684\u539f\u56e0\u4e4b\u4e00\u3002\u7814\u7a76\u8005\u9610\u660e\u4e86\u76d0\u5206\u8bf1\u5bfc\u673a\u4f53\u6f5c\u5728\u81f4\u6b8b\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u5206\u5b50\u673a\u5236\uff0c\u5728\u9ad8\u76d0\u5206\u73af\u5883\u4e2d\uff0c\u7ec6\u80de\u6216\u8bb8\u4f1a\u6fc0\u6d3b\u4e00\u79cd\u540d\u4e3a\u03b2-\u8fde\u73af\u86cb\u767d\/Wnt\u4fe1\u53f7\u901a\u8def\u7684\u5206\u5b50\u901a\u8def\u3002<\/span>
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2. \u6765\u81ea\u7f8e\u56fd\u51ef\u65af\u897f\u50a8\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff0c\u4e00\u79cd\u7279\u6b8a\u7684\u5355\u4e00\u86cb\u767d\u6216\u80fd\u8c03\u8282\u53d1\u80b2\u4e2d\u7cbe\u5b50\u5185\u90e8\u4e00\u8fde\u4e32\u5173\u952e\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u8fd9\u79cd\u540d\u4e3aDazl\u7684\u7279\u6b8a\u86cb\u767d\u80fd\u591f\u63a7\u5236\u5bf9\u53d1\u80b2\u4e2d\u5730\u7cbe\u5b50\u590d\u5236\u53ca\u751f\u5b58\u975e\u5e38\u5fc5\u8981\u7684\u591a\u4e2a\u57fa\u56e0\u7684\u529f\u80fd\uff0c\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u520a\u767b\u4e8e\u56fd\u9645\u6742\u5fd7 Reports\u4e0a\uff0c\u8be5\u7814\u7a76\u6709\u671b\u5e2e\u52a9\u5f00\u53d1\u6cbb\u7597\u7537\u6027\u4e0d\u80b2\u7684\u65b0\u578b\u7597\u6cd5\u3002<\/span><\/p>\n

3. \u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u8457\u540d\u6742\u5fd7\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u4e2d\u56fd\u9996\u90fd\u533b\u79d1\u5927\u5b66\u3001\u5317\u4eac\u5929\u575b\u533b\u9662\u3001\u9999\u6e2f\u79d1\u6280\u5927\u5b66\u7b49\u673a\u6784\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u5728\u7ee7\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u6cbb\u7597\u4e0a\u53d6\u5f97\u91cd\u5927\u7a81\u7834\u3002\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u9996\u6b21\u7ed8\u5236\u51fa\u4e86188\u4f8b\u7ee7\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\u84dd\u56fe\uff0c\u540c\u65f6\u7814\u7a76\u8005\u6307\u51fa\uff0c\u5927\u7ea614%\u7684\u7ee7\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u90fd\u8868\u73b0\u51fa\u4e86\u4e00\u79cd\u540d\u4e3aMETex14\u7684\u65b0\u578b\u7a81\u53d8\uff0c\u8be5\u7a81\u53d8\u4f1a\u4f7f\u5f97\u80bf\u7624\u51fa\u73b0\u6076\u6027\u751f\u957f\uff0c\u6b64\u524d\u7814\u7a76\u4eba\u5458\u7814\u7a76\u7684\u6837\u672c\u91cf\u8f83\u5c11\uff08\u901a\u5e38\u4e0d\u523020\uff09\uff0c\u56e0\u6b64\u5176\u6240\u5f97\u51fa\u7684\u7814\u7a76\u7ed3\u679c\u5177\u6709\u4e0d\u786e\u5b9a\u6027\u3002\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u9274\u522b\u51fa\u4e86\u4e00\u79cd\u540d\u4e3aPLB-1001\u7684MET\u6291\u5236\u5242\u5206\u5b50\uff0c\u8fd9\u79cd\u6291\u5236\u5242\u80fd\u591f\u900f\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u6f5c\u5728\u9009\u62e9\u6027\u9776\u5411\u4f5c\u7528\u7ee7\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u4ee5\u53caMETex14\u7a81\u53d8\u3002\u76ee\u524d\u5317\u4eac\u5929\u575b\u533b\u9662\u5df2\u7ecf\u83b7\u6279\u8fdb\u884cPLB-1001\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u800c\u4e14\u7814\u7a76\u4eba\u5458\u6240\u62db\u52df\u7684\u7814\u7a76\u5bf9\u8c61\u90fd\u662f\u90a3\u4e9b\u643a\u5e26\u7a81\u53d8\u6216\u6709\u7ee7\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u53f2\u5e76\u5728\u9002\u5f53\u5e74\u9f84\u8303\u56f4\u5185\u3002<\/span><\/p>\n

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4. \u65e5\u524d\uff0c\u5357\u5f00\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u6731\u6b63\u8302\u526f\u6559\u6388\u8bfe\u9898\u7ec4\u7684\u4e00\u9879\u7814\u7a76\uff0c\u63ed\u793a\u4e86\u6838\u819c\u86cb\u767dLEM4\u8bf1\u53d1\u4e73\u817a\u764c\u4ed6\u83ab\u6614\u82ac\u8010\u836f\u7684\u5206\u5b50\u673a\u5236\u3002LEM4\u6709\u671b\u6210\u4e3a\u4e73\u817a\u764c\u8010\u836f\u6cbb\u7597\u7684\u65b0\u9776\u70b9\u3002\u4ecb\u7ecd\u8be5\u7814\u7a76\u7684\u8bba\u6587\u5728\u7ebf\u53d1\u8868\u4e8e\u56fd\u9645\u77e5\u540d\u5b66\u672f\u671f\u520a\u300a\u81ea\u7136\u00b7\u901a\u8baf\u300b(Nature Communications)\u4e0a\u3002<\/span><\/p>\n

5. \u6765\u81ea\u7f8e\u56fd\u8fbe\u7eb3-\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u6240(Dana-Farber Cancer Institute) \u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\u4e86\u4e24\u79cd\u6076\u6027\u764c\u75c7\u7684\u65b0\u578b\u836f\u7269\u9776\u70b9\uff0c\u672a\u6765\u6709\u671b\u5f00\u53d1\u51fa\u65b0\u578b\u7597\u6cd5\u6765\u6cbb\u7597\u6ed1\u819c\u8089\u7624\u548c\u6076\u6027\u6746\u72b6\u80bf\u7624\uff0c\u76f8\u5173\u7814\u7a76\u6210\u679c\u520a\u767b\u4e8e\u56fd\u9645\u6742\u5fd7Nature Biology\u4e0a\u3002\u7814\u7a76\u8005\u8868\u793a\uff0c\u8fd9\u4e24\u79cd\u764c\u75c7\u4f9d\u8d56\u4e8e\u4e00\u79cd\u540d\u4e3ancBAF\u7684\u65b0\u578b\u5206\u5b50\u673a\u5668\uff0cncBAF\u5728\u8c03\u8282\u57fa\u56e0\u6d3b\u6027\u4e0a\u626e\u6f14\u7740\u5173\u952e\u89d2\u8272\uff0c\u5176\u7531\u591a\u79cd\u7279\u5f02\u6027\u7684\u86cb\u767d\u8d28\u4e9a\u5355\u4f4d\u7ec4\u6210\uff0c\u751f\u7269\u6027\u6216\u5316\u5b66\u6027\u5730\u5931\u6d3bncBAF\u7684\u7ec4\u5206\u6216\u80fd\u7279\u5f02\u6027\u5730\u635f\u4f24\u6ed1\u819c\u8089\u7624\u548c\u6076\u6027\u6746\u72b6\u80bf\u7624\u764c\u7ec6\u80de\u7cfb\u7684\u589e\u6b96\u3002Cigall Kadoch\u535a\u58eb\u8bf4\u9053\uff0c\u8fd9\u662f\u6211\u4eec\u5728\u9488\u5bf9\u987d\u56fa\u4fb5\u88ad\u6027\u764c\u75c7\u6cbb\u7597\u4e0a\u53d6\u5f97\u7684\u91cd\u8981\u7814\u7a76\u6210\u679c\uff0c\u672c\u6587\u7814\u7a76\u4e2d\u6211\u4eec\u9274\u522b\u51fa\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u764c\u75c7\u7279\u5f02\u6027\u9776\u70b9\uff0c\u672a\u6765\u6709\u671b\u5229\u7528\u5176\u5f00\u53d1\u65b0\u578b\u7684\u6297\u764c\u7597\u6cd5\u3002<\/span><\/p>\n

6. \u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u751f\u7269\u7269\u7406\u7814\u7a76\u6240\u7684\u9976\u5b50\u548c\uff08Zihe Rao\uff09\u9662\u58eb\u3001Quan Wang\u7814\u7a76\u5458\u3001\u5b59\u98de\uff08Fei Sun\uff09\u7814\u7a76\u5458\u53ca\u5176\u540c\u4e8b\u4eec\u5206\u79bb\u51fa\u803b\u57a2\u5206\u679d\u6746\u83cc\uff08Mycobacterium smegmatis\uff09\u7684\u547c\u5438\u94fe\u8d85\u7ea7\u590d\u5408\u7269\uff08respiratory supercomplex\uff09\uff0c\u5e76\u4e14\u5229\u7528\u4f4e\u6e29\u7535\u955c\uff08cryo-EM\uff09\u6280\u672f\u57283.5 \u00c5\u7684\u5206\u8fa8\u7387\u4e0b\u53ef\u89c6\u5316\u89c2\u5bdf\u5b83\u7684\u4e09\u7ef4\u7ed3\u6784\u3002\u8fd9\u79cd\u7ec6\u83cc\u4e0e\u7ed3\u6838\u5206\u679d\u6746\u83cc\u5b58\u5728\u7740\u5bc6\u5207\u7684\u4eb2\u7f18\u5173\u7cfb\uff0c\u800c\u4e14\u662f\u4e00\u79cd\u7528\u4e8e\u7814\u7a76\u8bb8\u591a\u7ec6\u83cc\u7269\u79cd\u7684\u6d41\u884c\u6a21\u578b\u3002\u8fd9\u79cd\u8be6\u7ec6\u7684\u7ed3\u6784\u63ed\u793a\u51fa\u7535\u5b50\u5982\u4f55\u5728\u4e00\u79cd\u8fc4\u4eca\u4e3a\u6b62\u89c2\u5bdf\u4e0d\u5230\u7684\u8fc7\u7a0b\u4e2d\u5728\u7ec6\u80de\u5185\u4f20\u9012\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e7410\u670825\u65e5\u5728\u7ebf\u53d1\u8868\u5728Science\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cAn electron transfer path connects subunits of a mycobacterial respiratory supercomplex\u201d\u3002<\/span><\/p>\n

7. \u6765\u81ea\u5317\u5fb7\u514b\u8428\u65af\u5927\u5b66\u5065\u5eb7\u79d1\u5b66\u4e2d\u5fc3\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u5bf9\u4e00\u79cd\u540d\u4e3aNGLY1\u7f3a\u9677\u7684\u7f55\u89c1\u9057\u4f20\u6027\u969c\u788d\u8fdb\u884c\u7814\u7a76\u53d1\u73b0\u4e86\u4e00\u79cd\u62b5\u5fa1\u9ed1\u8272\u7d20\u7624\u7684\u65b0\u578b\u9776\u5411\u6027\u7597\u6cd5\uff0c\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u520a\u767b\u4e8e\u56fd\u9645\u6742\u5fd7British Journal of Cancer\u4e0a\u3002<\/span><\/p>\n


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\u7248\u6743\u58f0\u660e<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u6587\u4e2d\u6240\u8ff0\u4ec5\u4ee3\u8868\u5176\u4e2a\u4eba\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u672c\u516c\u4f17\u53f7\u89c2\u70b9\u3002<\/span><\/strong>\u6b22\u8fce\u4e2a\u4eba\u3001\u7f51\u7ad9\u3001\u516c\u4f17\u53f7\u7b49\u5f15\u7528\u3001\u8f6c\u8f7d\u548c\u5206\u4eab\u3002\u975e\u4e2a\u4eba\u8f6c\u8f7d\u6216\u5f15\u7528\u672c\u7f51\u7248\u6743\u6240\u6709\u5185\u5bb9\u987b\u83b7\u5f97\u6388\u6743\u5e76\u5728\u9192\u76ee\u5904\u6ce8\u660e\u201c\u8f6c\u81ea\uff1a\u201d\u3002\u6b22\u8fce\u5408\u4f5c\uff0c\u8bf7\u8054\u7cfbiddds@simm.ac.cn\u3002<\/span><\/strong><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u56fd\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001 1. \u65b0\u57fa\u516c\u53f8\uff08Celgene\uff09\u5728\u7f8e\u56fd\u8840\u6db2\u534f\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u65b0\u836fRevlimid\uff08l […]<\/p>\n","protected":false},"author":1,"featured_media":60918,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60917"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=60917"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60917\/revisions"}],"predecessor-version":[{"id":60924,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60917\/revisions\/60924"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/60918"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=60917"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=60917"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=60917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}