{"id":60925,"date":"2018-11-09T01:00:00","date_gmt":"2018-12-07T03:02:55","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/921da06be8\/"},"modified":"2018-12-07T11:02:58","modified_gmt":"2018-12-07T03:02:58","slug":"921da06be8","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/60925\/","title":{"rendered":"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.09.15~10.14\uff09"},"content":{"rendered":"
\n

\u672c\u6587\u5bf9Clarivate Analytics Integrity\u6570\u636e\u5e93\u6536\u5f55\u7684\u4e8e2018.09.15~2018.10.14\u671f\u95f4\u516c\u5f00\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u8fdb\u884c\u4e86\u68b3\u7406\uff0c\u5e76\u91cd\u70b9\u5206\u6790\u4e86\u51e0\u5bb6\u5236\u836f\u5de8\u5934\u548c\u4e2d\u56fd\u672c\u571f\u5236\u836f\u4f01\u4e1a\/\u673a\u6784\u516c\u5e03\u7684\u4e13\u5229\u3002\u764c\u75c7\u4f9d\u7136\u662f\u4e13\u5229\u6700\u591a\u7684\u9002\u5e94\u75c7\uff0c\u5176\u4e2d\uff0c\u7f8e\u56fdMetacrine\u516c\u53f8\u81f4\u529b\u4e8e\u5f00\u53d1\u809d\u810f\u3001\u80c3\u80a0\u548c\u4ee3\u8c22\u75be\u75c5\u521b\u65b0\u7597\u6cd5\uff0c\u5176\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u4e13\u5229\u662f\u8fd1\u671f\u7684\u4eae\u70b9\u3002<\/p>\n

\u603b\u89c8<\/span><\/strong><\/p>\n

\u636eClarivate Analytics Integrity\u6570\u636e\uff08\u68c0\u7d22\u65e5\u671f\uff1a2018\u5e7410\u670817\u65e5\uff09\uff0c2018\u5e749\u670815\u65e5\u81f32018\u5e7410\u670814\u65e5\u671f\u95f4\uff0c\u5168\u7403\u516c\u5f00\u7684\u751f\u7269\u533b\u836f\u76f8\u5173\u57fa\u7840\u4e13\u5229\u5171\u8ba12248\u4ef6\uff0c\u5176\u4e2d\u5316\u5408\u7269\uff08drug substances\uff09\u4e13\u5229\u5171\u8ba1140\u4ef6\u3002<\/p>\n

\u672c\u9636\u6bb5\u516c\u5e03\u7684140\u4ef6\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\uff0c\u6d89\u53ca\u6cbb\u7597\u9886\u57df\u6700\u591a\u7684\u4e3a\u764c\u75c7\uff0c\u5176\u6b21\u4e3a\u708e\u75c7\uff0c\u4e13\u5229\u6570\u76ee\u8d85\u8fc77\u4ef6\u7684\u9002\u5e94\u75c7\u5305\u62ec\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u75bc\u75db\u3001\u4ee3\u8c22\u6027\u75be\u75c5\u3001\u80a5\u80d6\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7ec6\u83cc\u611f\u67d3\u3001\u591a\u53d1\u6027\u786c\u5316\u3001\u6291\u90c1\u3001\u773c\u90e8\u75be\u75c5\u3001\u809d\u7ea4\u7ef4\u5316\u3001\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08\u56fe1\uff0c\u6709\u4e9b\u4e13\u5229\u6d89\u53ca\u7684\u4e0d\u6b62\u4e00\u9879\u9002\u5e94\u75c7\uff0c\u7edf\u8ba1\u6709\u91cd\u590d\uff09\u3002<\/p>\n

\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.09.15~10.14\uff09\"<\/p>\n

\u56fe1\uff1a\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u6d89\u53ca\u7684\u9002\u5e94\u75c7\u5206\u5e03\uff08\u4ec5\u5c55\u793a\u4e13\u5229\u4ef6\u6570\u22657\u4ef6\u7684\u9002\u5e94\u75c7\uff09<\/p>\n

\u5168\u7403\u77e5\u540d\u836f\u4f01\u4e13\u5229\u7533\u8bf7\u5206\u6790<\/strong><\/span><\/p>\n

\u8be5\u9636\u6bb5\u516c\u5f00\u7684\u4e13\u5229\uff0c\u7f57\u6c0f\u516c\u53f8\u67098\u4ef6\u3001Metacrine\u516c\u53f8\u67095\u4ef6\uff0c\u6b66\u7530\u516c\u53f8\u67094\u4ef6\uff0c\u5176\u4ed6\u77e5\u540d\u836f\u4f01\u4e5f\u5747\u6709\u4e13\u5229\u88ab\u516c\u5e03\u3002<\/p>\n

\u7f57\u6c0f<\/span><\/p>\n

\u5728\u68c0\u7d22\u65f6\u95f4\u5185\uff0c\u7f57\u6c0f\u53ca\u5176\u5b50\u516c\u53f8\u57fa\u56e0\u6cf0\u514b\u516c\u5e038\u4ef6\u4e13\u5229\uff08\u88681\uff09\uff0cWO 2018183964\u3001WO 2018183956\u53caWO 2018167147\u4e09\u4ef6\u4e13\u5229\u5747\u662f\u7528\u4e8e\u80bf\u7624\u7684\u6cbb\u7597\u7684\u9020\u8840\u6fc0\u91761\uff08HPK1\uff09\u6291\u5236\u5242\uff0c\u7ed3\u6784\u5206\u522b\u4e3a\u5f02\u55b9\u5549\u7c7b\u3001\u8418\u5576\u7c7b\u3001\u6c2e\u6742\u5432\u54da\u7c7b\u5316\u5408\u7269\uff1bWO 2018167113\u548cWO 2018167001\u662f\u5185\u6bd2\u7d20\u7c7b\u6291\u5236\u5242\u7528\u4e8e\u773c\u90e8\u75be\u75c5\u7684\u6cbb\u7597\uff1bWO 2018166528\u662f\u4e00\u7c7b\u5627\u5576\u57fa\u5421\u5576\u6c27\u57fa\u8418\u57fa\u5316\u5408\u7269\uff0c\u4f5c\u7528\u4e8e\u808c\u9187\u9700\u6c42\u91761\uff08IRE1\uff09\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\uff1bWO 2018175707\u662f\u4e00\u7c7b\u53ef\u7528\u4e8e\u80bf\u7624\u6cbb\u7597\u76844-\u54cc\u5576-N-\uff08\u5627\u5576-4-\u57fa\uff09-7-\u78fa\u9170\u80fa\u82ef\u5e76\u4e8c\u6c22\u5421\u5583\u884d\u751f\u7269\u94a0\u901a\u9053\u6291\u5236\u5242\uff1bWO 2018166993\u662f\u5421\u5511\u6c2f\u82ef\u57fa\u5316\u5408\u7269\uff0c\u4f5c\u7528\u4e8eJauns\u6fc0\u9176\uff08JAK\uff09\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597\u54ee\u5598\u53ca\u708e\u75c7\u6027\u75be\u75c5\u3002<\/p>\n

\u88681\uff1a\u57fa\u56e0\u6cf0\u514b\u516c\u5f00\u7684\u836f\u7269\u5316\u5408\u7269\u4e13\u5229<\/p>\n

\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.09.15~10.14\uff09\"<\/p>\n

Metacrine<\/strong><\/span><\/p>\n

Metacrine\u516c\u53f8\u6210\u7acb\u4e8e2015\u5e74\uff0c\u662f\u4e00\u5bb6\u4ee5\u5f00\u53d1\u809d\u810f\u3001\u80c3\u80a0\u548c\u4ee3\u8c22\u75be\u75c5\u521b\u65b0\u7597\u6cd5\u7684\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u5728\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u548c\u5176\u4ed6\u80c3\u80a0\u7c7b\u75be\u75c5\u65b9\u9762\u5177\u6709\u7a81\u7834\u6027\u8fdb\u5c55\u3002\u68c0\u7d22\u65f6\u95f4\u5185\uff0cMetacrine\u516c\u53f8\u516c\u5f00\u7684\u4e13\u5229WO 2018170165\u3001WO 2018170166\u3001WO 2018170167\u3001WO 2018170173\u3001WO 2018170182\u5747\u4e3a\u6cd5\u5c3c\u916fX\u53d7\u4f53\uff08FXR\uff09\u6fc0\u52a8\u5242\uff0c\u7528\u4e8e\u809d\u810f\u3001\u80c3\u80a0\u548c\u4ee3\u8c22\u75be\u75c5\u7b49\u7c7b\u75be\u75c5\u7684\u6cbb\u7597\u3002<\/p>\n

\u88682\uff1aMetacrine\u516c\u53f8\u516c\u5f00\u7684\u836f\u7269\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7<\/p>\n

\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.09.15~10.14\uff09\"<\/p>\n

\u6b66\u7530<\/strong><\/span><\/p>\n

\u6b66\u7530\u516c\u53f8\u6700\u8fd1\u516c\u5f00\u4e866\u4ef6\u4e13\u5229\uff0c\u5206\u522b\u4e3aWO 2018182050\u6d89\u53ca\u7684\u662f\u4e00\u7c7b\u7528\u4e8e\u6cbb\u7597\u4ee3\u8c22\u7d0a\u4e71\u7684\u53d6\u4ee3\u7684\u73af\u4e59\u9178\u884d\u751f\u7269\uff0c\u4f5c\u7528\u4e8e\u6e38\u79bb\u8102\u80aa\u9178\u53d7\u4f531\uff1bWO 2018182051\u662f\u4e00\u7c7b\u7528\u4e8e\u7cd6\u5c3f\u75c5\u548c\u5fc3\u810f\u75c5\u7684\u808c\u9187\u516d\u78f7\u9178\u6fc0\u9176\uff08IP6K\uff09\u6291\u5236\u5242\uff1bWO 2018181345\u53caWO 2018181820\u5747\u662f\u4e00\u7c7b\u6742\u73af\u5316\u5408\u7269\uff0c\u524d\u8005\u4e3a\u6838\u7ea2\u7ec6\u80de\u76f8\u5173\u56e0\u5b502\u8c03\u8282\u5242\u3001Kelch\u6837ECH\u76f8\u5173\u86cb\u767d1\u6291\u5236\u5242\uff0c\u540e\u8005\u4e3a\u78f7\u9178\u4e8c\u916f\u9176\uff08PDE\uff09\u7c7b\u6291\u5236\u5242\uff0c\u4e24\u7c7b\u6742\u73af\u5316\u5408\u7269\u5747\u53ef\u7528\u4e8e\u591a\u79cd\u75be\u75c5\u7684\u6cbb\u7597\uff1bWO 2018181847\u662f\u4e00\u7c7b\u7528\u4e8e\u7cd6\u5c3f\u75c5\u548c\u80a5\u80d6\u6cbb\u7597\u7684\u82b3\u9999\u65cf\u5316\u5408\u7269\uff0c\u4f5c\u7528\u4e8e\u6e38\u79bb\u8102\u80aa\u9178\u53d7\u4f531\uff1bWO 2018183145\u662f\u4e00\u7c7b\u54cc\u5576\u57fa\u548c\u54cc\u55ea\u57fa\u53d6\u4ee3\u82b3\u9999\u65cf\u7fa7\u9170\u80fa\uff0c\u5c5ecAMP\u62ee\u6297\u5242\u548cG\u86cb\u767d\u5076\u8054\u53d7\u4f53-6\u8c03\u8282\u5242\uff0c\u7528\u4e8e\u795e\u7ecf\u7cbe\u795e\u7c7b\u75be\u75c5\u7684\u6cbb\u7597\u3002<\/p>\n

\u88683\uff1a\u6b66\u7530\u516c\u53f8\u516c\u5f00\u7684\u836f\u7269\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7<\/p>\n

\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.09.15~10.14\uff09\"<\/p>\n

\u5176\u4ed6\u56fd\u9645\u5236\u836f\u516c\u53f8\uff08\u8282\u9009\uff09<\/strong><\/span><\/p>\n

\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u8fd1\u671f\u516c\u5e03\u4e86\u4e24\u4ef6\u4e13\u5229\uff0c\u5747\u4e3a\u53d8\u6001\u53cd\u5e94\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u764c\u75c7\u3001\u611f\u67d3\u6027\u75be\u75c5\u3001\u708e\u75c7\u6027\u75be\u75c5\u6cbb\u7597\u7684\u76f8\u5173\u4e13\u5229\uff0c\u5176\u4e2dWO 2018167019\u4e3a\u4e00\u7c7b\u7532\u82ef\u78fa\u9170\u4e59\u9178\u57fa\u5316\u5408\u7269\u4f5c\u4e3aD3\u78f7\u9178\u7518\u6cb9\u9178\u8131\u6c22\u9176\uff08PHGDH\uff09\u6291\u5236\u5242\uff0cWO 2018172206\u4e3a\u4e00\u7c7b\u4fee\u9970\u73af\u4e8c\u6838\u82f7\u9178\u5316\u5408\u7269\u4f5c\u4e3a\u975e\u7279\u5f02\u6027\u7ec6\u80de\u56e0\u5b50\u53d7\u4f53\u8c03\u8282\u5242\u548c\u5e72\u6270\u7d20\u57fa\u56e0\u86cb\u767d\u6291\u5236\u5242\u523a\u6fc0\u7269\u3002<\/p>\n

\u68c0\u7d22\u65f6\u95f4\u5185\uff0cLeadiant\u516c\u53f8\u5171\u67094\u4ef6\u516c\u5f00\u7684\u836f\u7269\u5316\u5408\u7269\u4e13\u5229\uff0cWO 2018177863\u3001WO 2018177861\u3001WO 2018177860\u53caWO 2018177857\u5747\u4e3a\u809d\u7d20\u6291\u5236\u5242\uff0c\u6d89\u53ca\u8113\u6bd2\u75c7\u3001\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u6cbb\u7597\u3002<\/p>\n

Janssen\u516c\u53f8\u516c\u5f00\u4e864\u4ef6\u4e13\u5229\uff1aWO 2018187652\u6d89\u53ca\u4e00\u7c7b2,4-\u4e8c\u6c28\u57fa\u5627\u5576\u884d\u751f\u7269\u4f5c\u4e3a\u7ec4\u80faH4\u8c03\u8282\u5242\uff0c\u7528\u4e8e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3001\u771f\u83cc\u611f\u67d3\u548c\u94f6\u5c51\u75c5\u6cbb\u7597\uff1bWO 2018178238\u548cWO 2018178240\u5747\u6d89\u53ca\u6291\u5236\u767b\u9769\u70ed\u75c5\u6bd2\u590d\u5236\u7684\u53d6\u4ee3\u5432\u54da\u5549\u884d\u751f\u7269\uff1bWO 2018178280\u4e3a\u4e00\u7c7b4-\u4e8c\u6c2e\u8418\u548c\u5421\u5576\u5e76\u5421\u55ea\u884d\u751f\u7269\u4f5c\u4e3a\u78f7\u8102\u9170\u808c\u9187-3\u6fc0\u9176\u03b2\uff08PI3K-\u03b2\uff09\u6291\u5236\u5242\u3002<\/p>\n

Bayer\u516c\u53f84\u4ef6\u4e13\u5229\uff1aWO 2018172250\u662f\u4e00\u7c7b2-\u7532\u57fa\u55b9\u5511\u5549\u5316\u5408\u7269\uff0c\u4f5c\u4e3aRas GTPase\u6291\u5236\u5242\u7528\u4e8e\u80bf\u7624\u6cbb\u7597\uff1bWO 2018177899\u548cWO 2018177889\u5747\u4e3a\u4e00\u7c7b\u6291\u5236\u7ec6\u80de\u5468\u671f\u7d20\u4f9d\u8d56\u6027\u6fc0\u91769\u7684\u5927\u73af\u5316\u5408\u7269\uff1bWO 2018184976\u662f\u4e00\u7c7b\u53d6\u4ee3\u54aa\u5511\u5e76[1,2-a]\u5421\u5576\u9170\u80fa\u7c7b\u5316\u5408\u7269\u4f5c\u4e3a\u9e1f\u82f7\u9178\u73af\u5316\u9176\u523a\u6fc0\u7269\uff0c\u7528\u4e8e\u75f4\u5446\u3001\u52c3\u8d77\u529f\u80fd\u969c\u788d\u3001\u9ad8\u8840\u538b\u7684\u6cbb\u7597\u3002<\/p>\n

\u88684\uff1a\u5176\u4ed6\u56fd\u9645\u516c\u53f8\u516c\u5f00\u7684\u836f\u7269\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7<\/p>\n

\"\u68b3\u7406\uff1a\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.09.15~10.14\uff09\"<\/p>\n

\u6211\u56fd\u5236\u836f\u516c\u53f8\u53ca\u7814\u7a76\u673a\u6784\u4e13\u5229\u516c\u5e03\u5217\u4e3e<\/strong><\/span><\/p>\n

\u68c0\u7d22\u671f\u95f4\u5185\uff0c\u6211\u56fd\u5236\u836f\u516c\u53f8\u53ca\u7814\u7a76\u673a\u6784\u5171\u516c\u5f00\u4e8624\u4ef6\u4e13\u5229\uff0c\u4e0b\u9762\u8282\u9009\u90e8\u5206\u4e13\u5229\u91cd\u70b9\u63cf\u8ff0\u3002<\/p>\n

\u6d77\u6b63\u836f\u4e1a\u65b0\u516c\u5f00\u76842\u4ef6\u4e13\u5229\u4e2d\uff0c\u4e13\u5229WO 2018171698\u548cWO 2018171699\u5206\u522b\u6d89\u53ca\u6c30\u57fa\u53d6\u4ee3\u7684\u6742\u82b3\u57fa\u5627\u5576\u916e\u884d\u751f\u7269\u548c\u6742\u82b3\u57fa\u5627\u5576\u916e\u884d\u751f\u7269\uff0c\u5747\u4f5c\u7528\u4e8e\u4e59\u9170\u8f85\u9176A\u7fa7\u5316\u9176\uff0c\u7528\u4e8e\u6cbb\u7597\u7ec6\u83cc\u611f\u67d3\u3001\u8102\u80aa\u809d\u3001\u809d\u764c\u3001\u8102\u4ee3\u8c22\u7d0a\u4e71\u3001\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u3001\u975e\u80f0\u5c9b\u7d20\u4f9d\u8d56\u578b\u7cd6\u5c3f\u75c5\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u80a5\u80d6\u7b49\u591a\u79cd\u75be\u75c5\u7684\u6cbb\u7597\u3002<\/p>\n

\u6052\u745e\u533b\u836f\u516c\u5f00\u76842\u4ef6\u4e13\u5229WO 2018166493\u6d89\u53ca\u4e00\u7c7b[4,3-c]\u6742\u82b3\u57fa\u5627\u5576-5-\u80fa\u884d\u751f\u7269\uff0c\u4f5c\u4e3a\u817a\u82f7A2a\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u7528\u4e8e\u8111\u635f\u4f24\u3001\u764c\u75c7\u3001\u6291\u90c1\u3001\u8ba4\u77e5\u969c\u788d\u3001\u8102\u80aa\u809d\u75be\u75c5\u3001\u809d\u7ea4\u7ef4\u5316\u3001\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3001\u8111\u5352\u4e2d\u3001\u7761\u7720\u969c\u788d\u7b49\u591a\u79cd\u75be\u75c5\u6cbb\u7597\uff1bWO 2018171611\u662f\u4e00\u7c7b6-\u5421\u5511-[1,2,4]-[1,2,4]\u4e09\u5511[4,3-a]\u5421\u5576-3-\u9170\u80fa\u884d\u751f\u7269\uff0c\u53ef\u6291\u5236ALK-5\u86cb\u767d\u6fc0\u9176\u3001TGF-\u03b2\u53d7\u4f53\u914d\u4f53\u3001p38 MAP\u6fc0\u9176\u3001\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53-2\u53d7\u4f53\u7b49\u591a\u79cd\u673a\u5236\uff0c\u7528\u4e8e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u3001\u764c\u75c7\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u809d\u7ea4\u7ef4\u5316\u3001\u80ba\u75be\u75c5\u3001\u80be\u75be\u75c5\u3001\u9aa8\u8d28\u758f\u677e\u3001\u786c\u76ae\u75c5\u7b49\u7684\u6cbb\u7597\u3002<\/p>\n

WO 2018171602\u662f\u4e00\u7c7b\u8132\u5316\u5408\u7269\u4f5c\u4e3a\u5432\u54da\u9170\u80fa\u5421\u54af\u70f72,3-\u53cc\u52a0\u6c27\u9176\uff08IDO\uff09\u548c\u8272\u6c28\u91782,3-\u53cc\u52a0\u6c27\u9176\uff08TDO\uff09\u53cc\u91cd\u6291\u5236\u5242\uff0c\u7531\u5317\u4eac\u8d5b\u6797\u6cf0\u533b\u836f\u3001\u6b63\u5927\u5929\u6674\u836f\u4e1a\u3001\u8fde\u4e91\u6e2f\u6da6\u4f17\u5236\u836f\u8054\u5408\u7533\u8bf7\u7684\u4e13\u5229\uff0c\u53ef\u7528\u4e8e\u80bf\u7624\u3001\u75c5\u6bd2\u611f\u67d3\u7b49\u75be\u75c5\u7684\u6cbb\u7597\u3002<\/p>\n

\u8fbd\u5b81\u5229\u950b\u79d1\u6280\u5f00\u53d1\u6709\u9650\u516c\u53f8\u4e13\u5229WO 2018177218\u6d89\u53ca\u4e00\u7c7b3\uff0c5-\u4e8c\u53d6\u4ee3\u7532\u57fa\u5421\u5511\u5e76[1,5-a]\u5627\u5576-7-\u915a\u76d0\u7c7b\u4f3c\u7269\u53ca\u5176\u884d\u751f\u7269\uff0c\u4e3b\u8981\u7528\u4e8e\u5404\u7c7b\u611f\u67d3\u75be\u75c5\u7684\u6cbb\u7597\u3002<\/p>\n

\u4e1c\u9633\u5149\u5236\u836f\u516c\u53f8\u548c\u52a0\u62d3\u79d1\u5b66\u516c\u53f8\u7684\u4e13\u5229WO 2018169700\u6d89\u53ca\u4e00\u7c7b\u65b0\u578b\u53d6\u4ee3\u7684\u6742\u82b3\u57fa\u5316\u5408\u7269\uff0c\u4f5c\u4e3aJanus\u6fc0\u9176\uff08Jak\uff09\u3001Flt3\uff08FLK2\/STK1\uff09\u548caurora\uff08ARK\uff09\u6fc0\u9176\u6291\u5236\u5242\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u3001\u8fc7\u654f\u3001\u79fb\u690d\u6392\u65a5\u3001\u708e\u75c7\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7b49\u7684\u6cbb\u7597\u3002<\/p>\n

\u82cf\u5dde\u767e\u6781\u5e03\u5171\u533b\u836f\u79d1\u6280\u6709\u9650\u516c\u53f8\u4e13\u5229WO 2018175512\u662f\u4e00\u7c7b\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5242\uff0c\u7528\u4e8e\u80bf\u7624\u3001\u708e\u75c7\u548c\u514d\u75ab\u6027\u75be\u75c5\u7684\u6cbb\u7597\u3002<\/p>\n

\u88685\uff1a\u56fd\u5185\u65b0\u516c\u5f00\u7684\u836f\u7269\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\u5217\u4e3e<\/p>\n

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\u5c0f\u7ed3<\/span><\/strong><\/p>\n

\u8fd1\u671f\u516c\u5f00\u7684\u4e13\u5229\u4e2d\uff0c\u5728\u9002\u5e94\u75c7\u4e0a\uff0c\u9664\u80bf\u7624\u5916\uff0c\u51fa\u73b0\u4e86\u6d89\u53ca\u773c\u90e8\u75be\u75c5\u3001\u809d\u7ea4\u7ef4\u5316\u3001\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u7b49\u6cbb\u7597\u7684\u836f\u7269\u5316\u5408\u7269\u4e13\u5229\uff1b\u4ece\u7533\u8bf7\u4eba\u89d2\u5ea6\u6765\u770b\uff0c\u7f57\u6c0f\u4f9d\u7136\u662f\u4e13\u6ce8\u80bf\u7624\u836f\u7269\u7814\u53d1\uff0c\u6b66\u7530\u8fd1\u671f\u516c\u5f00\u7684\u4e13\u5229\u591a\u662f\u7cd6\u5c3f\u75c5\u7b49\u4ee3\u8c22\u7c7b\u75be\u75c5\uff0c\u65b0\u664b\u5236\u836f\u516c\u53f8Metacrine\u81f4\u529b\u4e8e\u5f00\u53d1\u809d\u810f\u3001\u80c3\u80a0\u548c\u4ee3\u8c22\u75be\u75c5\u521b\u65b0\u7597\u6cd5\uff0c\u5c24\u5176\u662f\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u836f\u7269\u7684\u5f00\u53d1\u3002<\/p>\n

\u3010\u53c2\u8003\u8d44\u6599\u3011
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1. \u79d1\u777f\u552f\u5b89Integrity\u6570\u636e\u5e93, \u68c0\u7d22\u65e5\u671f: 2018\u5e7410\u670817\u65e5.<\/span><\/p>\n

2. \u4e07\u8c61\u4e91\u6570\u636e\u5e93, \u68c0\u7d22\u65e5\u671f: 2018\u5e7410\u670823\u65e5.<\/span><\/p>\n


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<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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