{"id":60978,"date":"2018-10-24T01:00:00","date_gmt":"2018-12-07T03:03:25","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/9fc1449ffa\/"},"modified":"2018-12-07T11:03:26","modified_gmt":"2018-12-07T03:03:26","slug":"9fc1449ffa","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/60978\/","title":{"rendered":"\u6eb6\u7624\u75c5\u6bd2\u884c\u4e1a\u62a5\u544a"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word;\"><span style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word;color: rgb(0, 128, 255);font-size: 15px;\">\u4f5c\u8005 l \u558b\u558b\u558b\u558b &nbsp;<\/span><\/strong><strong style=\"letter-spacing: 0.544px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word;\"><span style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word;color: rgb(0, 128, 255);font-size: 15px;\">\u7f16\u8f91&nbsp;l \u7ec6\u80de\u623f\u95f4<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><span style=\"color:#0080ff;\"><span style=\"font-size: 15px;\"><strong>\u8f6c\u8f7d\u81ea\uff1a<\/strong><\/span><\/span><span style=\"color:#0080ff;\"><span style=\"font-size: 15px;\"><strong><\/strong><\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u6eb6\u7624\u75c5\u6bd2\u7597\u6cd5\u662f\u4e00\u79cd\u901a\u8fc7\u75c5\u6bd2\u9009\u62e9\u6027\u611f\u67d3\u80bf\u7624\u7ec6\u80de\u6765\u6740\u4f24\u80bf\u7624\u7684\u65b0\u578b\u80bf\u7624\u6cbb\u7597\u65b9\u6cd5\u3002\u6eb6\u7624\u75c5\u6bd2\u662f\u4e00\u7c7b\u5177\u6709\u590d\u5236\u80fd\u529b\u7684\u80bf\u7624\u6740\u4f24\u578b\u75c5\u6bd2\uff0c\u80fd\u9009\u62e9\u6027\u611f\u67d3\u80bf\u7624\u7ec6\u80de\u5e76\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u590d\u5236\u7ee7\u800c\u6740\u4f24\u80bf\u7624\u7ec6\u80de\uff0c\u5e76\u523a\u6fc0\u673a\u4f53\u4ea7\u751f\u7279\u5f02\u6027\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u4e3b\u8981\u5206\u4e3a\u4e24\u5927\u7c7b\uff0c\u4e00\u7c7b\u662f\u5929\u7136\u5bf9\u4e8e\u80bf\u7624\u7ec6\u80de\u5177\u6709\u7279\u5f02\u6027\u611f\u67d3\u6216\u6740\u4f24\u80fd\u529b\u7684\u75c5\u6bd2\uff0c\u6bd4\u5982\u547c\u80a0\u5b64\u75c5\u6bd2\u3001\u65b0\u57ce\u75ab\u75c5\u6bd2\u7b49\uff1b\u53e6\u4e00\u7c7b\u662f\u7ecf\u8fc7\u4eba\u4e3a\u6539\u9020\u8fc7\uff0c\u5bf9\u4e8e\u80bf\u7624\u7ec6\u80de\u5177\u6709\u7279\u5f02\u6740\u4f24\u80fd\u529b\u7684\u75c5\u6bd2\uff0c\u6bd4\u5982\u817a\u75c5\u6bd2\u3001\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2\u7b49\u3002\u81ea\u7136\u754c\u4e2d\u53ea\u6709\u5c11\u6570\u75c5\u6bd2\u53ef\u4ee5\u81ea\u7136\u5730\u53d1\u751f\u6eb6\u7624\uff0c\u5927\u591a\u6570\u9700\u8981\u8fdb\u884c\u57fa\u56e0\u6539\u9020\u540e\u624d\u80fd\u5b9e\u73b0\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u9776\u5411\u611f\u67d3\u548c\u6cbb\u7597\u7684\u4f5c\u7528\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u6eb6\u7624\u75c5\u6bd2\u4e3b\u8981\u5206\u4e3a\u4e24\u7c7b\uff1a<strong>\u5929\u7136\u75c5\u6bd2\u682a\u4e0e\u57fa\u56e0\u6539\u9020\u75c5\u6bd2\u682a\u3002<\/strong>\uff081\uff09\u5929\u7136\u75c5\u6bd2\u682a\u6307\u81ea\u7136\u72b6\u6001\u4e0b\u672a\u7ecf\u4fee\u9970\u6216\u8fde\u7eed\u4f20\u4ee3\u540e\u6bd2\u529b\u8870\u51cf\u7684\u75c5\u6bd2\u682a\uff0c\u5305\u62ec\u91ce\u751f\u578b\u53ca\u81ea\u7136\u53d8\u5f02\u7684\u5f31\u75c5\u6bd2\u682a\u3002\u5982\u547c\u80a0\u5f27\u75c5\u6bd2\u3001\u65b0\u57ce\u75ab\u75c5\u6bd2\u3001\u6d41\u884c\u6027\u816e\u817a\u708e\u75c5\u6bd2\u3001\u897f\u5c3c\u7f57\u6cb3\u75c5\u6bd2\u3001\u817a\u75c5\u6bd2\u3001\u725b\u75d8\u75c5\u6bd2\u3002\uff082\uff09\u57fa\u56e0\u6539\u9020\u75c5\u6bd2\u682a\uff1a\u5220\u9664\u75c5\u6bd2\u67d0\u4e9b\u5173\u952e\u57fa\u56e0\u3001\u52a0\u8f7d\u5916\u6e90\u6cbb\u7597\u57fa\u56e0\u3001\u75c5\u6bd2\u5fc5\u987b\u57fa\u56e0\u524d\u63d2\u5165\u7ec4\u7ec7\u6216\u80bf\u7624\u7279\u5f02\u6027\u542f\u52a8\u5b50\u6765\u63a7\u5236\u6eb6\u7624\u75c5\u6bd2\u5728\u80bf\u7624\u7ec6\u80de\u5185\u590d\u5236\u3002\u5982\uff1a\u52a0\u8f7d\u7c92\u7ec6\u80de\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\uff08GM-CSF\uff09\u7684JX-594\u3001T-vec\u3001DNX-2401\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/0-1544151806.jpg\" alt=\"\u6eb6\u7624\u75c5\u6bd2\u884c\u4e1a\u62a5\u544a\" title=\"\u6eb6\u7624\u75c5\u6bd2\u884c\u4e1a\u62a5\u544a\"  \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u6eb6\u7624\u75c5\u6bd2\u4e3b\u8981\u901a\u8fc7\u4ee5\u4e0b\u4e09\u79cd\u673a\u5236\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528<\/span><strong><span style=\"font-size: 15px;color: rgb(255, 169, 0);\">[1]<\/span><\/strong><span style=\"font-size: 15px;\">\u3002 <\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 15px;\">1\uff09\u80bf\u7624\u9009\u62e9\u7279\u5f02\u6027\u673a\u5236\uff1a<\/span><\/strong><span style=\"font-size: 15px;\">\u901a\u8fc7\u5bf9\u75c5\u6bd2\u611f\u67d3\u5bbf\u4e3b\u6240\u9700\u7684\u5173\u952e\u86cb\u767d\u8fdb\u884c\u4fee\u9970\uff0c\u964d\u4f4e\u75c5\u6bd2\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u7684\u611f\u67d3\uff0c\u4ece\u800c\u5b9e\u73b0\u75c5\u6bd2\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u7279\u5f02\u6027\u611f\u67d3\uff0c\u540c\u65f6\u75c5\u6bd2\u53ea\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u590d\u5236\uff0c\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\u4e0d\u590d\u5236\uff0c\u7ee7\u800c\u5b9e\u73b0\u5bf9\u80bf\u7624\u7684\u9776\u5411\u51fb\u6740\uff1b <\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 15px;\">2\uff09\u75c5\u6bd2\u4ecb\u5bfc\u7684\u80bf\u7624\u6740\u4f24\u673a\u5236\uff1a<\/span><\/strong><span style=\"font-size: 15px;\">\u6eb6\u7624\u75c5\u6bd2\u6210\u529f\u9776\u5411\u5e76\u611f\u67d3\u80bf\u7624\u7ec6\u80de\u540e\uff0c\u75c5\u6bd2\u4ee5\u7ec6\u80de\u4f5c\u4e3a\u52a0\u5de5\u5382\u8fdb\u884c\u5927\u91cf\u590d\u5236\uff0c\u6700\u7ec8\u8fbe\u5230\u88c2\u89e3\u80bf\u7624\u7ec6\u80de\u7684\u76ee\u7684\uff0c\u80bf\u7624\u7ec6\u80de\u88c2\u89e3\u540e\u91ca\u653e\u7684\u5b50\u4ee3\u75c5\u6bd2\u53c8\u7ee7\u7eed\u611f\u67d3\u90bb\u8fd1\u7684\u80bf\u7624\u7ec6\u80de\uff1b <\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 15px;\">3\uff09\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u673a\u5236\uff1a<\/span><\/strong><span style=\"font-size: 15px;\">\u75c5\u6bd2\u8fdb\u5165\u673a\u4f53\u540e\u4f1a\u5f15\u53d1\u514d\u75ab\u7cfb\u7edf\u7684\u6e05\u9664\uff0c\u8bf1\u5bfc\u6dcb\u5df4\u7ec6\u80de\u548c\u6297\u539f\u9012\u5448\u7ec6\u80de\uff08<\/span><span style=\"font-size: 15px;\">APCs<\/span><span style=\"font-size: 15px;\">\uff09<\/span><span style=\"font-size: 15px;\">\u6d78\u6da6\u80bf\u7624\u611f\u67d3\u4f4d\u70b9\uff0c\u540c\u65f6\u75c5\u6bd2\u88c2\u89e3\u80bf\u7624\u7ec6\u80de\u540e\u91ca\u653e\u7684\u80bf\u7624\u6297\u539f\u53ef\u589e\u5f3a<\/span><span style=\"font-size: 15px;\"> APCs <\/span><span style=\"font-size: 15px;\">\u7684\u6297\u539f\u9012\u5448\u80fd\u529b\uff0c\u4ece\u800c\u4ea7\u751f\u9488\u5bf9\u80bf\u7624\u6297\u539f\u7684\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\uff0c\u6700\u7ec8\u5f62\u6210\u957f\u6548\u7684\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\uff0c\u53ef\u6709\u6548\u9632\u6b62\u80bf\u7624\u7684\u590d\u53d1\u548c\u8f6c\u79fb\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u6eb6\u7624\u75c5\u6bd2\u76f8\u6bd4\u5176\u4ed6\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u5177\u6709\u660e\u663e\u4f18\u52bf\uff0c\u6f5c\u529b\u5de8\u5927\uff0c\u5177\u6709\u5b89\u5168\u6027\u53ef\u9760\u3001\u7597\u6548\u597d\u7b49\u4f18\u52bf\uff0c\u5982\u4e0b\u56fe\uff1a<\/span><\/p>\n<p style=\"text-align: center;\">\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 15px;\">\u76ee\u524d\u5168\u7403\u6709\u4e09\u6b3e\u836f\u7269\u6210\u529f\u83b7\u6279\u4e0a\u5e02\uff0c<\/span><\/strong><span style=\"font-size: 15px;\">\u6eb6\u7624\u75c5\u6bd2\u6280\u672f\u57fa\u672c\u6210\u719f\u3002\u5168\u7403\u8303\u56f4\u5185\u9996\u4e2a\u88ab\u8ba4\u53ef\u7684\u662f 2015\u5e74FDA\u6279\u51c6\u7684T-vec\uff0c\u88ab\u6279\u51c6\u7528\u4e8e\u9996\u6b21\u624b\u672f\u540e\u590d\u53d1\u7684\u4e0d\u53ef\u5207\u9664\u7684\u4fb5\u72af\u76ae\u80a4\u3001\u76ae\u4e0b\u548c\u6dcb\u5df4\u7ed3\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u5c40\u90e8\u6cbb\u7597\u3002\u9664\u6b64\u4e4b\u5916\uff0c 2004 \u5e74 <span style=\"font-size: 15px;text-align: justify;\">Rigvir<\/span>\u5728\u62c9\u8131\u7ef4\u4e9a\u83b7\u6279\u6cbb\u7597\u591a\u79cd\u764c\u75c7\uff0c\u4e3b\u8981\u662f\u9ed1\u8272\u7d20\u7624\uff0c\u6839\u636e\u8d44\u6599\u663e\u793a\uff0c75\uff05\u7684\u62c9\u8131\u7ef4\u4e9a\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5df2\u7ecf\u63a5\u53d7\u4e86Rigvir\u7597\u6cd5\uff1b 2005 \u5e74\u5b89\u67ef\u745e\u5728\u6211\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u539f\u53d1\u7076\u3001\u4e34\u5e8a\u665a\u671f\u3001\u590d\u53d1\u7684\u5934\u9888\u90e8\u80bf\u7624\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">CFDA\u83b7\u6279\u65b9\u9762\uff0c<strong>\u6211\u56fd\u7b2c\u4e00\u4e2a\u6279\u51c6\u7684\u6eb6\u7624\u75c5\u6bd2\u662f\u4e0a\u6d77\u4e09\u7ef4\uff08S<\/strong><\/span><strong style=\"font-size: 15px;\">unway<\/strong><strong style=\"font-size: 15px;\">\uff09\u751f\u7269\u6280\u672f\u516c\u53f8\u7814\u53d1\u7684H101\u57fa\u56e0\u4fee\u9970\u6eb6\u7624\u817a\u75c5\u6bd2\uff0c<\/strong><span style=\"font-size: 15px;\">\u5176\u5728<\/span><span style=\"font-size: 15px;\">2005<\/span><span style=\"font-size: 15px;\">\u5e74\u83b7\u5f97<\/span><span style=\"font-size: 15px;\">CFDA<\/span><span style=\"font-size: 15px;\">\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u5934\u9888\u90e8\u80bf\u7624\u3002<\/span><span style=\"font-size: 15px;\">Oncolytics<\/span><span style=\"font-size: 15px;\">\u751f\u7269\u6280\u672f\u516c\u53f8\u7684<\/span><span style=\"font-size: 15px;\">Reolysin<\/span><span style=\"font-size: 15px;\">\u6b63\u5904\u4e8e\u6cbb\u7597\u5934\u9888\u764c\u7684<\/span><span style=\"font-size: 15px;\">III<\/span><span style=\"font-size: 15px;\">\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u4e34\u5e8a\u8d44\u6599\u663e\u793a\uff0c\u8fd9\u4e2a<\/span><span style=\"font-size: 15px;\">III<\/span><span style=\"font-size: 15px;\">\u671f\u4e34\u5e8a\u8bd5\u9a8c\u663e\u793a\u83b7\u5f97\u4e86\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u80bf\u7624\u7f29\u5c0f\uff1b\u6b64\u5916\uff0c\u7ed3\u80a0\u3001\u76f4\u80a0\u764c\u7684\u65e9\u671f\u7ed3\u679c\u603b\u5171\u6709<\/span><span style=\"font-size: 15px;\">31<\/span><span style=\"font-size: 15px;\">\u9879\u4e34\u5e8a\u7814\u7a76\u5df2\u7ecf\u5b8c\u6210\u6216\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u5176\u4e2d\u5305\u62ec\u8bb8\u591a<\/span><span style=\"font-size: 15px;\">Reolysin<\/span><span style=\"font-size: 15px;\">\u8bd5\u9a8c\u4ee5\u53ca\u5404\u79cd\u5b9e\u4f53\u80bf\u7624\u7684\u6807\u51c6\u5316\u7597\u65b9\u6848\u7b49\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 15px;\">\u76ee\u524d\u5904\u4e8e\u4e34\u5e8aII\u671f\u7684\u4ea7\u54c1\u5305\u62ec\uff1a<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">&nbsp;1\uff09 Jennerex\u516c\u53f8\u7684JX-594\u76ee\u524d\u6b63\u5904\u4e8e\u809d\u7ec6\u80de\u764c\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0cJX-594\u662f\u80f8\u82f7\u6fc0\u9176\u7f3a\u5931\u7684\u75d8\u82d7\u75c5\u6bd2\u5e76\u878d\u5408\u4e86GM-CSF\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">&nbsp;2\uff09Seneca Valley\u75c5\u6bd2\uff08<\/span><span style=\"font-size: 15px;\">NTX-010<\/span><span style=\"font-size: 15px;\">\uff09\u548c\uff08<\/span><span style=\"font-size: 15px;\">SVV-001<\/span><span style=\"font-size: 15px;\">\uff09\u662f\u6eb6\u7624\u578b\u5c0f\u6838\u7cd6\u6838\u9178\u75c5\u6bd2\uff0c\u7528\u4e8e\u6cbb\u7597\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u795e\u7ecf\u6bcd\u7ec6\u80de\u7624\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">&nbsp;3\uff09ColoAd1\u7531Psioxus Therapeutics\u516c\u53f8\u4f7f\u7528\u5b9a\u5411\u8fdb\u5316\u7684\u65b9\u6cd5\u5f00\u53d1\u7684\u6eb6\u7624\u75c5\u6bd2\uff0c\u5df2\u6210\u529f\u5b8c\u6210\u4e86\u4e34\u5e8aI\u671f\u8bd5\u9a8c\u3002\u8fd9\u4e9b\u60a3\u8005\u4f7f\u7528\u7684\u75c5\u6bd2\u6837\u54c1\u7ecf\u8fc7\u9759\u8109\u5185\u9012\u9001\u540e\u663e\u793a\u5728\u80bf\u7624\u90e8\u4f4d\u5185\u75c5\u6bd2\u5927\u91cf\u590d\u5236\u800c\u6b63\u5e38\u7ec4\u7ec7\u5f71\u54cd\u751a\u5c0f\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">&nbsp;4\uff09Cavatak \u662f\u4e00\u79cd\u67ef\u8428\u5947\u75c5\u6bd2\uff0c\u6b63\u5904\u4e8e\u6076\u6027\u9ed1\u8272\u7d20\u7624\u6cbb\u7597\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">&nbsp;5\uff09ONCOS-102\u662f\u7f16\u7801\u4ebaGM-CSF\u7684\u4eba\u8840\u6e05\u578b5\/3\u817a\u75c5\u6bd2\uff0c\u5176\u7ecf\u8fc7\u4f18\u5316\u4ee5\u8bf1\u5bfc\u764c\u75c7\u60a3\u8005\u7684\u5168\u8eab\u6027\u6297\u80bf\u7624T\u7ec6\u80de\u5e94\u7b54\u3002\u5bf9\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u7684\u6cbb\u7597\u5df2\u7ecf\u8fdb\u5165II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 15px;\">\u5904\u4e8e\u4e34\u5e8aI\u671f\u7684\u4ea7\u54c1\u5305\u62ec\uff1a<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">&nbsp;1\uff09Virttu Biologics\u7684SEPREHVIR\uff08<\/span><span style=\"font-size: 15px;\">HSV-1716<\/span><span style=\"font-size: 15px;\">\uff09\u5b8c\u6210\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3001\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u548c\u9ed1\u7d20\u7624\u7684I\u671f\u4e34\u5e8a\u5b9e\u9a8c\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">&nbsp;2\uff09Oncos Therapeutics\u516c\u53f8\u7684CGTG-102\uff08<\/span><span style=\"font-size: 15px;\">Ad5\/3-D24-GMCSF<\/span><span style=\"font-size: 15px;\">\uff09\u5df2\u7ecf\u5728\u516c\u53f8Advanced Therapy Access Program\u4e2d\u7528\u4e8e\u6cbb\u7597200\u540d\u665a\u671f\u764c\u75c7\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">&nbsp;3\uff09\u7531Genelux\u5f00\u53d1\u7684GL-ONC1\u5904\u4e8e\u9759\u8109\u7ed9\u836f\u7528\u4e8e\u5b9e\u4f53\u7624\u7684\u4e34\u5e8a\u5b9e\u9a8cIb\u9636\u6bb5\u3002\u6b63\u5728\u8fdb\u884c\u5176\u4ed6\u8bd5\u9a8c\uff0c\u5305\u62ec\u6076\u6027\u80f8\u8154\u79ef\u6db2\u60a3\u8005\u7684\u80f8\u8154\u5185\u7ed9\u836f\uff0c\u665a\u671f\u8179\u819c\u764c\u75c5\u4eba\u8179\u8154\u6ce8\u5c04\uff0c\u8179\u8154\u5185\u6ce8\u5c04\u590d\u53d1\u5375\u5de2\u764c\u5728\u5934\u9888\u90e8\u764c\u75c7\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u622a\u81f32018\u5e749\u6708\uff0c\u6709\u591a\u9879\u5173\u4e8e\u6eb6\u7624\u75c5\u6bd2\u7684\u4ea4\u6613\u4e0e\u5408\u4f5c\u9879\u76ee\u5728\u4e2d\u56fd\u836f\u4f01\u4e2d\u5c55\u5f00\u3002\u5305\u62ec\u6cd5\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8Transgen\u4e0e\u5929\u58eb\u529b\u7684\u5408\u4f5c\u3001Jennerex Biotherapeutics\u7684JX-594\u3001Tocagen\u7684Toca-511\u4ee5\u53caOncolytics Biotech\u7684Reolysin\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"font-size: 15px;\">\u6eb6\u7624\u75c5\u6bd2\u8054\u5408\u514d\u75ab\u7597\u6cd5\u6f5c\u529b\u5de8\u5927<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u6eb6\u7624\u75c5\u6bd2\u8054\u5408\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53ef\u4ee5\u589e\u5f3a\u539f\u6709\u7597\u6548<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">1\u3001\u4e24\u9879\u91cd\u78c5\u7814\u7a76\u5c55\u793a\u4e86\u6eb6\u7624\u75c5\u6bd2\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8054\u5408\u7597\u6cd5\u7684\u5f3a\u5927\u7597\u6548\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">2017 \u5e74 9 \u6708\uff0c\u56fd\u9645\u8457\u540d\u671f\u520a\u300a\u300b\u53d1\u8868\u4e86 PD-1 \u6297\u4f53 Keytruda \u4e0e\u6eb6\u7624\u75c5\u6bd2\u7597\u6cd5 Lmlygic\uff08<\/span><span style=\"font-size: 15px;\">T-vec<\/span><span style=\"font-size: 15px;\">\uff09\u8054\u5408\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u4e00\u9879\u91cd\u78c5\u4e34\u5e8a\u6570\u636e\u3002\u7ed3\u679c\u8868\u660e\uff0c\u8054\u5408\u6cbb\u7597\u53ef\u4ee5\u4f7f\u60a3\u8005\u7684\u5e94\u7b54\u7387\u63d0\u5347\u81f362%\uff0c\u8fdc\u8fdc\u9ad8\u4e8e\u5355\u72ec\u4f7f\u7528Keytruda\u6216T-vec\u6cbb\u7597\u7684\u9884\u671f\u7f13\u89e3\u7387\uff08<\/span><span style=\"font-size: 15px;\">\u901a\u5e38\u7ea6\u4e3a 35%-40%<\/span><span style=\"font-size: 15px;\">\uff09\u3002\u540c\u5e7410\u6708\u5168\u7403\u751f\u7269\u5236\u836f\u5de8\u5934Amgen\uff08<\/span><span style=\"font-size: 15px;\">\u5b89\u8fdb<\/span><span style=\"font-size: 15px;\">\uff09\u4e5f\u516c\u5e03\u4e86\u4e00\u9879\u6eb6\u7624\u75c5\u6bd2Lmlygic\uff08<\/span><span style=\"font-size: 15px;\">T-vec<\/span><span style=\"font-size: 15px;\">\uff09\u8054\u5408\u68c0\u67e5\u70b9\u6291\u5236\u5242CTLA-4\u6297\u4f53\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u7684\u6700\u65b0\u4e34\u5e8a\u6570\u636e\u3002\u7ed3\u679c\u8868\u660e\uff0c\u8054\u5408\u7597\u6cd5\u4f7f\u60a3\u8005\u7684\u603b\u4f53\u53cd\u5e94\u7387\u6bd4CTLA-4\u6297\u4f53 Yervoy\uff08L<\/span><span style=\"font-size: 15px;\">pilimumab<\/span><span style=\"font-size: 15px;\">\uff09\u5355\u836f\u6cbb\u7597\u7ffb\u4e86\u4e00\u756a\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">2\u3001\u6eb6\u7624\u75c5\u6bd2\u8054\u5408\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53ef\u4ee5\u6cbb\u7597\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7597\u6548\u751a\u5fae\u7684\u201c\u51b7\u80bf\u7624\u201d\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5bf9\u4e8e\u4e09\u9634\u6027\u4e73\u817a\u764c\u548c\u8111\u80bf\u7624\u60a3\u8005\u7597\u6548\u751a\u5fae\uff0c\u4f46\u662f 2018 \u5e741\u6708\u53d1\u8868\u5728\u300aScience Translational Medicine\u300b\u7684\u4e24\u7bc7\u8bba\u6587\u53d1\u73b0\uff0c\u514d\u75ab\u7597\u6cd5\u8054\u5408\u6eb6\u7624\u75c5\u6bd2\u53ef\u4ee5\u6cbb\u7597\u4fb5\u88ad\u6027\u4e73\u817a\u764c\u548c\u81f4\u547d\u8111\u7624\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u65e9\u671f\u7ed9\u4e88\u7684\u6eb6\u7624\u75c5\u6bd2\u6cbb\u7597\uff08<\/span><span style=\"font-size: 15px;\">\u5728\u624b\u672f\u5207\u9664\u4e4b\u524d<\/span><span style=\"font-size: 15px;\">\uff09\u6539\u53d8\u4e86\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\uff0c\u5e76\u4e14\u589e\u5f3a\u4e86\u968f\u540e\u63a5\u53d7\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u7684\u6548\u679c\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">3\u3001\u4e0e CTLA-4 \u548c IDO \u6291\u5236\u5242\u7ec4\u5408\u76f8\u6bd4\uff0c\u6eb6\u7624\u75c5\u6bd2\u8054\u5408\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7ec4\u5408\u6548\u679c\u66f4\u4f18\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\">\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u6eb6\u7624\u75c5\u6bd2T-vec\u4e0ePD-1\u6291\u5236\u5242Keytruda\u7684\u8054\u7528\u4e0d\u4ec5\u6709\u6548\u7387\u66f4\u9ad8\uff0c\u800c\u4e143-4\u7ea7\u526f\u4f5c\u7528\u7684\u53d1\u751f\u7387\u4e5f\u663e\u8457\u4f4e\u4e8eCTLA-4\u548cIDO\u6291\u5236\u5242\u7ec4\u5408\uff0c\u7531\u6b64\u53ef\u89c1\uff0c\u6eb6\u7624\u75c5\u6bd2\u8054\u5408\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7ec4\u5408\u672a\u6765\u6f5c\u529b\u5de8\u5927\uff0c\u6709\u671b\u8d85\u8d8a\u539f\u6709\u8054\u5408\u514d\u75ab\u7597\u6cd5\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 15px;\"><\/span><br  \/><strong><span style=\"font-size: 12px;color: rgb(255, 169, 0);\">\u53c2\u8003\u6587\u732e<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12px;\">1. Kaufman H L, Kohlhapp F J, Zloza A. Oncolytic viruses: a new class of immunotherapy drugs[J]. Nature reviews Drug discovery, 2015, 14(9): 642.<\/span><\/p>\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4f5c\u8005 l \u558b\u558b\u558b\u558b &nbsp;\u7f16\u8f91&nbsp;l \u7ec6\u80de\u623f\u95f4 \u8f6c\u8f7d\u81ea\uff1a \u6eb6\u7624\u75c5\u6bd2\u7597\u6cd5\u662f\u4e00\u79cd\u901a\u8fc7\u75c5\u6bd2\u9009\u62e9\u6027\u611f\u67d3\u80bf [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":60979,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60978"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=60978"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60978\/revisions"}],"predecessor-version":[{"id":60981,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/60978\/revisions\/60981"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/60979"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=60978"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=60978"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=60978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}