{"id":61045,"date":"2018-09-30T01:00:00","date_gmt":"2018-12-07T03:04:07","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/03d314696b\/"},"modified":"2018-12-07T11:04:15","modified_gmt":"2018-12-07T03:04:15","slug":"03d314696b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/61045\/","title":{"rendered":"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.08.15-2018.09.14\uff09"},"content":{"rendered":"
\n

\u636eClarivate Analytics Cortellis\u6570\u636e\uff08\u68c0\u7d22\u65e5\u671f\uff1a2018\u5e749\u670817\u65e5\uff09\uff0c2018\u5e748\u670815\u65e5\u81f32018\u5e749\u670814\u65e5\u671f\u95f4\uff0c\u5168\u7403\u9996\u6b21\u516c\u5f00\u7684\u4e13\u5229\u5171\u8ba118810\u4ef6\uff0c\u6d89\u53ca\u751f\u7269\u5236\u836f\u884c\u4e1a\u7684\u67091826\u4ef6\uff0c\u5176\u4e2d\u516c\u5f00\u6700\u591a\u7684\u4e3a\u5236\u5242\u4e13\u5229\uff0c\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4ea7\u54c1\u4e13\u5229\u5171\u8ba1160\u4ef6\u3002<\/span><\/p>\n

\u672c\u9636\u6bb5\u516c\u5e03\u7684160\u4ef6\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\uff0c\u6d89\u53ca\u6cbb\u7597\u9886\u57df\u6700\u591a\u7684\u4e3a\u80bf\u7624\uff0c\u5176\u6b21\u4e3a\u80c3\u80a0\u75be\u75c5\u3001\u514d\u75ab\u6027\u75be\u75c5\u3001\u708e\u6027\u75be\u75c5\u3001\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff1b\u6d89\u53ca\u7684\u5177\u4f53\u9002\u5e94\u75c7\u4e2d\uff0c\u4e73\u817a\u764c\u3001\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3001\u524d\u5217\u817a\u764c\u3001\u725b\u76ae\u7663\u548c\u8111\u80bf\u7624\u4f4d\u5217\u524d\u4e94\uff0c\u4e13\u5229\u6570\u76ee\u8d85\u8fc77\u4ef6\u7684\u9002\u5e94\u75c7\u5982\u56fe1\u6240\u793a\u3002\uff08\u6709\u4e9b\u4e13\u5229\u6d89\u53ca\u7684\u4e0d\u53ea\u4e00\u9879\u9002\u5e94\u75c7\uff0c\u7edf\u8ba1\u6709\u91cd\u590d\uff09\u3002<\/span><\/p>\n

\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.08.15-2018.09.14\uff09\"<\/p>\n

\u56fe1\uff1a\u5316\u5408\u7269\u4e13\u5229\u6d89\u53ca\u7684\u9002\u5e94\u75c7\u5206\u5e03\uff08\u4ec5\u5c55\u793a\u4e13\u5229\u4ef6\u6570\u8d85\u8fc77\u4ef6\u7684\u9002\u5e94\u75c7\uff09<\/span><\/p>\n

\n
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\u56fd\u5916\u77e5\u540d\u836f\u4f01\u4e13\u5229\u516c\u5e03\u5206\u6790<\/section>\n<\/section>\n
<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n

\u6768\u68ee\uff08Janssen\uff09\u5236\u836f<\/span><\/strong><\/span><\/p>\n

\u6768\u68ee\u5236\u836f\u662f\u5f3a\u751f\u5236\u836f\u7684\u5b50\u516c\u53f8\uff0c\u4ea7\u54c1\u8986\u76d6\u4e86\u7cbe\u795e\u75be\u75c5\u3001\u795e\u7ecf\u75be\u75c5\u3001\u80bf\u7624\u75be\u75c5\u3001\u514d\u75ab\u75be\u75c5\u3001\u80c3\u80a0\u9053\u75be\u75c5\u3001\u771f\u83cc\u7c7b\u75be\u75c5\u4ee5\u53ca\u4f20\u67d3\u6027\u75be\u75c5\u7b49\u9886\u57df\u3002\u8fd1\u671f\u516c\u5e035\u4ef6\u4e13\u5229\uff0cWO 2018145620\u6d89\u53ca\u65b0\u578b\u82ef\u78fa\u9170\u80fa\u7c7b5-HT 2b\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u7528\u4e8e\u809d\u7ea4\u7ef4\u5316\u6216\u809d\u786c\u5316\u7684\u6f5c\u5728\u6cbb\u7597\uff1bWO 2018154133\u8981\u6c42\u4fdd\u62a4\u54cc\u5576\u3001\u5417\u5549\u6216\u54cc\u55ea\u53d6\u4ee3\u7684\u65b0\u578b\u6742\u73af\u7c7b\u5316\u5408\u7269\uff0c\u4f5c\u4e3aO-GlcNAc\u6c34\u89e3\u9176\u6291\u5236\u5242\uff0c\u7528\u4e8eTau\u86cb\u767d\u75c5\u53d8\u6216\u4f34\u6709C90RF72\u7a81\u53d8\u5f15\u8d77\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u5305\u62ec\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u3001\u8fdb\u884c\u6027\u6838\u4e0a\u6027\u9ebb\u75f9\u3001\u808c\u840e\u7f29\u6027\u810a\u9ad3\u4fa7\u7d22\u786c\u5316\u75c7\u548c\u989d\u989e\u53f6\u75f4\u5446\u7b49\uff1bWO 2018162443\u3001WO 2018162444\u548cWO 2018162445\u5747\u8981\u6c42\u4fdd\u62a4\u65b0\u578b\u4e09\u73af\u7c7b\u03b2\u5206\u6ccc\u9176\u6291\u5236\u5242\uff0c\u7528\u4e8e\u03b2\u5206\u6ccc\u9176\u5f02\u5e38\u5f15\u53d1\u7684\u76f8\u5173\u75be\u75c5\u6cbb\u7597\uff0c\u5982AD\u3001\u8870\u8001\u3001\u75f4\u5446\u3001\u5e74\u9f84\u76f8\u5173\u7684\u9ec4\u6591\u53d8\u6027\u3001\u2161\u578b\u7cd6\u5c3f\u75c5\u548c\u5176\u4ed6\u4ee3\u8c22\u6027\u75be\u75c5\u3002<\/span><\/p>\n

\u88681\uff1a\u6768\u68ee\u5236\u836f\u516c\u5f00\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7<\/span><\/strong><\/p>\n

\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.08.15-2018.09.14\uff09\" <\/span>\u793c\u6765<\/span><\/strong><\/p>\n

\u4e13\u5229WO 2018148856\u6d89\u53ca2,8-\u4e8c\u6c2e\u6742\u87ba[4,5]\u7678\u70f7-1-\u916e\u7c7b\u5316\u5408\u7269\u53ca\u5176\u76d0\u3001\u7ec4\u5408\u7269\uff0c\u4f5c\u4e3a\u6c28\u57fa\u8132\u654f\u611f\u6027\u6c28\u57fa\u6c27\u5316\u9176\/\u8840\u7ba1\u7c98\u9644\u86cb\u767d-1\uff08SSAO\/VAP-1\uff09\u6291\u5236\u5242\uff0c\u7528\u4e8e\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u7684\u6cbb\u7597\u3002\u4e13\u5229WO 2018157277\u8981\u6c42\u4fdd\u62a4\u5f02\u55b9\u5549\u7c7b\u51cb\u4ea1\u4fe1\u53f7\u8c03\u8282\u6fc0\u91761\uff08ASK1\uff09\u6291\u5236\u5242\uff0c\u540c\u6837\u7528\u4e8eNASH\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

\u4e13\u5229WO 2018160550\u548cWO 2018160547\u5747\u6d89\u53ca\u4e00\u7c7b\u65b0\u578b\u87ba\u73af\u53d6\u4ee3\u5316\u5408\u7269\u53ca\u5176\u76d0\u3001\u7ec4\u5408\u7269\uff0c\u4f5c\u4e3a\u89c6\u9ec4\u9178\u76f8\u5173\u7684\u5b64\u513f\u53d7\u4f53gamma-t\uff08ROR\u03b3t\uff09\u6291\u5236\u5242\uff0c\u7528\u4e8e\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u3001\u94f6\u5c51\u75c5\u6027\u5173\u8282\u708e\u3001\u8f74\u6027\u810a\u67f1\u5173\u8282\u708e\u548c\u8840\u6e05\u9634\u6027\u810a\u67f1\u5173\u8282\u75c5\u7684\u6f5c\u5728\u6cbb\u7597\u3002<\/span><\/p>\n

\u88682\uff1a\u793c\u6765\u516c\u5f00\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7<\/span><\/strong><\/p>\n

\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.08.15-2018.09.14\uff09\"<\/p>\n

Oblique Therapeutics<\/span><\/strong><\/span><\/p>\n

\u8be5\u516c\u53f8\u6700\u8fd1\u516c\u5f00\u4e864\u4ef6\u4e13\u5229\uff0c\u5206\u522b\u4e3aWO 2018146471\u3001WO 2018146472\u3001WO 2018146469\u548cWO 2018146468\uff0c\u5747\u6d89\u53ca\u53d6\u4ee3\u5421\u5576\u7c7b\u5316\u5408\u7269\uff0c\u4f5c\u4e3a\u786b\u6c27\u8fd8\u86cb\u767d\u8fd8\u539f\u91761\uff08TrxR1\uff09\u548c\u8c37\u80f1\u7518\u80bd\u8fd8\u539f\u9176\u6291\u5236\u5242\uff0c\u7528\u4e8e\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3001\u8111\u764c\u3001\u524d\u5217\u817a\u764c\u3001\u8840\u6db2\u80bf\u7624\u3001\u5c24\u6587\u8089\u7624\u3001\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3001\u80be\u764c\u3001\u8180\u80f1\u764c\u3001\u809d\u6bcd\u7ec6\u80de\u7624\u548c\u80c3\u764c\u7b49\u764c\u75c7\u7684\u6f5c\u5728\u6cbb\u7597\u3002<\/span><\/p>\n

\u88683\uff1aOblique Therapeutics\u516c\u5f00\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7<\/span><\/strong><\/p>\n

\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.08.15-2018.09.14\uff09\" <\/span>\u5176\u4ed6\u77e5\u540d\u836f\u4f01<\/span><\/strong><\/strong><\/span><\/p>\n

\u65e5\u672c\u7b2c\u4e00\u4e09\u5171\u5236\u836f\u4e13\u5229WO 2018155398\u6d89\u53ca\u65b0\u578b\u82ef\u7532\u9170\u80fa\u7c7b\u884d\u751f\u7269\u4f5c\u4e3a\u8272\u6c28\u9178\u9176\u6291\u5236\u5242\uff0c\u7528\u4e8e\u964d\u4f4e\u8840\u6db2\u4e2d\u5432\u54da\u786b\u9178\u76d0\u548c\u6291\u5236\u80be\u529f\u80fd\u7684\u6076\u5316\uff0c\u5e76\u5ef6\u7f13\u6162\u6027\u80be\u75c5\u4fdd\u5b88\u6cbb\u7597\u60a3\u8005\u7684\u80be\u66ff\u4ee3\u6cbb\u7597\u7684\u8f6c\u53d8\u3002\u4e13\u5229WO 2018151239\u6d89\u53ca\u65b0\u578b3,6-\u4e8c\u6c22-2H-\u544b\u5583[2,3-e]\u5432\u54da\u884d\u751f\u7269\uff0c\u4e13\u5229WO 2018151240\u6d89\u53ca\u65b0\u578b\u53d6\u4ee3\u7684\u56db\u6c22\u73af\u620a\u57fa[e]\u5432\u54da\u884d\u751f\u7269\uff0c\u5747\u4f5c\u4e3a\u9178\u654f\u611f\u79bb\u5b50\u901a\u9053(ASIC\uff0c\u516c\u5f00\u4e3aASIC1a\u3001ASIC2a\u548cASIC3)\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u5fc3\u529b\u8870\u7aed\u3001\u9ad8\u8840\u538b\u3001\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u708e\u6027\u80a0\u75c5\u3001\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u3001\u76ae\u708e\u3001\u504f\u5934\u75db\u3001\u9752\u5149\u773c\u3001\u764c\u75c7\u548c\u7cd6\u5c3f\u75c5\u7b49\u75be\u75c5\u3002<\/span><\/p>\n

\u62dc\u8033\u516c\u53f8\u4e13\u5229WO 2018146010\u6d89\u53ca2-\u6742\u82b3\u57fa-3-\u6c27\u4ee3-2\uff0c3-\u4e8c\u6c22\u54d2\u55ea-4-\u7532\u9170\u80fa\u7c7b\u5316\u5408\u7269\u4f5c\u4e3a\u82b3\u70c3\u53d7\u4f53\uff08AHR\uff09\u62ee\u6297\u5242\uff0c\u7528\u4e8e\u80bf\u7624\u53ca\u5176\u4ed6AHR\u4fe1\u53f7\u5f02\u5e38\u76f8\u5173\u7684\u75be\u75c5\u6cbb\u7597\u3002<\/span><\/p>\n

\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u4e13\u5229WO 2018148626\u8981\u6c42\u4fdd\u62a4\u65b0\u7684[1,2,4]\u4e09\u5511[1,5-a]\u5421\u5576\u884d\u751f\u7269\uff08\u901a\u5f0f\u2160\uff5e\u2168\uff09\u4f5c\u4e3a\u916a\u86cb\u767d\u6fc0\u9176RIPK1\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u708e\u6027\u80a0\u75c5\u3001\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u3001\u514b\u7f57\u6069\u75c5\u3001\u94f6\u5c51\u75c5\u3001\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001NASH\u548c\u5fc3\u529b\u8870\u7aed\u7b49\u3002<\/span><\/p>\n

\u57fa\u56e0\u6cf0\u514b\u548cRQx Pharmaceuticals\u8054\u5408\u7533\u8bf7\u7684\u4e13\u5229WO 2018149419\u8981\u6c42\u4fdd\u62a4\u4e0e\u82b3\u9709\u7d20\u7c7b\u4f3c\u7684\u65b0\u578b\u5927\u73af\u7c7b\u5316\u5408\u7269\uff0c\u7528\u4f5c\u7ec6\u83cc1\u578b\u4fe1\u53f7\u80bd\u9176\uff08SpsB\uff09\u6291\u5236\u5242\u6cbb\u7597\u7ec6\u83cc\u611f\u67d3\uff0c\u7279\u522b\u662f\u7531lepB\u4ecb\u5bfc\u7684\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u3001\u6dcb\u7403\u83cc\u3001\u94dc\u7eff\u5047\u5355\u80de\u83cc\u3001\u5927\u80a0\u6746\u83cc\u3001\u4f24\u5bd2\u6c99\u95e8\u83cc\u3001\u798f\u6c0f\u5fd7\u8d3a\u83cc\u3001\u9c8d\u66fc\u4e0d\u52a8\u6746\u83cc\u3001\u5e7d\u95e8\u87ba\u6746\u83cc\u548c\u8270\u96be\u68ad\u83cc\u5f15\u8d77\u7684\u9769\u5170\u6c0f\u9634\u6027\u7ec6\u83cc\u611f\u67d3\u3002<\/span><\/p>\n

GSK\u4e13\u5229WO 2018154466\u6d89\u53ca\u4e00\u7cfb\u5217\u4e8c\u6c22\u55b9\u5549\u916e\u7c7b\u5316\u5408\u7269\u4f5c\u4e3aHBe\u6216HBs\u6297\u539f\u6291\u5236\u5242\u7528\u4e8e\u4e59\u809d\u75c5\u6bd2\u611f\u67d3\u6cbb\u7597\uff0c\u8fd9\u4e9b\u5316\u5408\u7269\u53ef\u6291\u5236HBe\u6216HBs\u6297\u539f\u4ece\u611f\u67d3\u7684\u809d\u7ec6\u80de\u4e2d\u91ca\u653e\u3002\u4e13\u5229WO 2018154520\u6d89\u53ca\u65b0\u578b\u6742\u73af\u7c7b\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u86cb\u767d\u6fc0\u91761\uff08RIP1\uff09\u6291\u5236\u5242\uff0c\u5e76\u8981\u6c42\u4fdd\u62a4\u8be5\u7c7b\u5316\u5408\u7269\u4e0e\u514d\u75ab\u8c03\u8282\u5242\u5c24\u5176\u662f\u6297CTLA4\u6297\u4f53\u6216\u6297PD-1\u6297\u4f53\u7684\u8054\u5408\u5e94\u7528\uff0c\u7528\u4e8e\u5305\u542b\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u3001\u80f0\u817a\u764c\u3001\u80f0\u817a\u8f6c\u79fb\u817a\u764c\u3001\u809d\u764c\u3001\u95f4\u76ae\u7624\u3001\u9ed1\u8272\u7d20\u7624\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u548c\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7b49\u764c\u75c7\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

\u536b\u624d\u5236\u836f\u4e13\u5229WO 2018152450\u8981\u6c42\u4fdd\u62a4\u65b0\u578b\u73af\u72b6\u4e8c\u6838\u82f7\u9178\u884d\u751f\u7269\uff0c\u4f5c\u4e3a\u5e72\u6270\u7d20\u57fa\u56e0\u523a\u6fc0\u86cb\u767d\uff08STING\uff09\u523a\u6fc0\u5242\u6cbb\u7597\u542b\u6709REF\u3001HAQ\u6216WT STING\u7b49\u4f4d\u57fa\u56e0\u7684\u8f6c\u79fb\u6027\u764c\u75c7\uff0c\u5305\u62ec\u9ed1\u8272\u7d20\u7624\u3001\u5927\u80a0\u764c\u3001\u4e73\u817a\u764c\u3001\u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\u3001\u7ed3\u80a0\u764c\u3001\u809d\u764c\u548c\u80f6\u8d28\u7624\u3002<\/span><\/p>\n

\u88684\uff1a\u5176\u4ed6\u77e5\u540d\u836f\u4f01\u516c\u5f00\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7<\/span><\/strong><\/p>\n

\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.08.15-2018.09.14\uff09\"<\/p>\n

\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.08.15-2018.09.14\uff09\"<\/span><\/p>\n

\n
\n
\n
 \u6211\u56fd\u5236\u836f\u516c\u53f8\u53ca\u7814\u7a76\u673a\u6784\u4e13\u5229\u516c\u5e03\u5206\u6790<\/section>\n<\/section>\n
<\/section>\n<\/section>\n<\/section>\n

<\/strong><\/p>\n

\u68c0\u7d22\u671f\u95f4\u5185\uff0c\u6211\u56fd\u5236\u836f\u516c\u53f8\u53ca\u7814\u7a76\u673a\u6784\u5171\u516c\u5f00\u4e8626\u4ef6\u4e13\u5229\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u65b0\u516c\u5f00\u4e865\u4ef6\u4e13\u5229\u7533\u8bf7\uff0c\u5e7f\u4e1c\u4e1c\u9633\u5149\u836f\u4e1a\u3001\u798f\u5efa\u5e7f\u751f\u5802\u836f\u4e1a\u3001\u5317\u4eac\u8d5b\u7279\u660e\u5f3a\u533b\u836f\u65b0\u516c\u5f00\u4e862\u4ef6\u4e13\u5229\uff0c\u5176\u4ed6\u516c\u53f8\u5982\u56db\u5ddd\u79d1\u4f26\u535a\u6cf0\u751f\u7269\u533b\u836f\u3001\u6c5f\u82cf\u8c6a\u68ee\u5236\u836f\u3001\u4e0a\u6d77\u957f\u68ee\u836f\u4e1a\u3001\u5e7f\u5dde\u6052\u8bfa\u5eb7\u533b\u836f\u7b49\u5206\u522b\u6709\u4e00\u4ef6\u4e13\u5229\u516c\u5f00\u3002\u6211\u4eec\u8282\u9009\u90e8\u5206\u4e13\u5229\u91cd\u70b9\u63cf\u8ff0\u3002<\/span><\/p>\n

\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240<\/span><\/strong><\/p>\n

\u65b0\u516c\u5f00\u76845\u4ef6\u4e13\u5229\u4e2d\uff0c\u4e13\u5229WO 2018161922\u6d89\u53ca\u4e00\u7cfb\u5217\u5177\u6709\u86cb\u767d\u7cbe\u6c28\u9178\u7532\u57fa\u8f6c\u79fb\u91765\uff08PRMT5\uff09\u6291\u5236\u6d3b\u6027\u7684\u5316\u5408\u7269\u53ca\u5176\u5236\u5907\u548c\u5e94\u7528\u3002\u8be5\u7c7b\u5316\u5408\u7269\u5728\u9884\u9632\u548c\/\u6216\u6cbb\u7597\u764c\u75c7\u76f8\u5173\u75be\u75c5\u5177\u6709\u6f5c\u5728\u5e94\u7528\u3002\u7528\u653e\u5c04\u6027\u540c\u4f4d\u7d20\u6cd5\u6d4b\u8bd5\u5316\u5408\u7269\u7684PRMT5\u6291\u5236\u6d3b\u6027\uff0c\u8be5\u7c7b\u5316\u5408\u7269\u7684IC50\u503c\u57280.0085\uff5e2.7\u00b5M\u4e4b\u95f4\uff0c\u9633\u6027\u5bf9\u7167EPZ015666\u7684IC50\u503c\u4e3a0.047\u00b5M\uff0c\u90e8\u5206\u5316\u5408\u7269\u7684\u6d3b\u6027\u5f3a\u4e8e\u9633\u6027\u5bf9\u7167\u7269\u3002\u53e6\u5916\uff0c\u90e8\u5206\u5316\u5408\u7269\u7684\u7ec6\u80de\u589e\u6b96\u6291\u5236\u4f5c\u7528\u4e5f\u4f18\u4e8e\u9633\u6027\u5bf9\u7167\u7269\u3002<\/span><\/p>\n

\u4e13\u5229WO 2018161876\u6d89\u53ca\u4e00\u7c7b\u65b0\u578b\u7ed3\u6784\u7684\u6eb4\u7ed3\u6784\u57df\u8bc6\u522b\u86cb\u767d\uff08BRD\uff09\u6291\u5236\u5242\u53ca\u5176\u5236\u5907\u65b9\u6cd5\uff0c\u8fd8\u6d89\u53ca\u6b64\u7c7b\u5316\u5408\u7269\u5728\u5236\u5907\u7528\u4e8e\u6cbb\u7597\u7531\u6eb4\u7ed3\u6784\u57df\u8bc6\u522b\u86cb\u767d\u4ecb\u5bfc\u7684\u75be\u75c5\u7684\u836f\u7269\u4e2d\u7684\u5e94\u7528\u3002\u4f53\u5916\u6d3b\u6027\u6d4b\u8bd5\u4e2d\uff0c\u8be5\u7c7b\u5316\u5408\u7269\u5bf9BRD4\u86cb\u767d\u3001\u4eba\u9aa8\u9ad3\u7624\u7ec6\u80deMM.1S\u5177\u6709\u8f83\u597d\u7684\u6291\u5236\u6d3b\u6027\uff0c\u5728\u4eba\u548c\u5c0f\u9f20\u7684\u809d\u5fae\u7c92\u4f53\u4e2d\u4ee3\u8c22\u90fd\u6bd4\u8f83\u7a33\u5b9a\u3002<\/span><\/p>\n

\u4e13\u5229WO 2018161831\u6d89\u53ca\u4e00\u7c7bG\u86cb\u767d\u5076\u8054\u53d7\u4f5384\uff08GPR84\uff09\u7684\u914d\u4f53\u5206\u5b50\u3002\u8be5\u7c7b\u914d\u4f53\u5206\u5b50\u5177\u6709GPR84\u7684\u62ee\u6297\u6d3b\u6027\uff0c\u53ef\u4ee5\u7ade\u4e89\u6027\u7684\u6291\u5236GPR84\u7684\u6fc0\u52a8\u5242\u5f15\u8d77\u7684\u8be5\u53d7\u4f53\u7684\u6fc0\u6d3b\uff0c\u53ef\u7528\u4e8e\u56e0GPR84\u9ad8\u8868\u8fbe\u6216\u5174\u594b\u6027\u8fc7\u9ad8\u6240\u5bfc\u81f4\u7684\u76f8\u5173\u75be\u75c5\u7684\u6cbb\u7597\uff0c\u5982\u591a\u53d1\u6027\u786c\u5316\u75c7\u3001\u708e\u75c7\u6027\u80a0\u75c5\u3001\u5173\u8282\u708e\u7b49\u3002<\/span><\/p>\n

\u4e13\u5229WO 2018149382\u6d89\u53ca\u4e00\u7cfb\u5217\u542b\u90bb\u6c28\u57fa\u6742\u82b3\u73af\u5feb\u57fa\u7684\u5316\u5408\u7269\u53ca\u5176\u5236\u5907\u65b9\u6cd5\u548c\u7528\u9014\u3002\u5316\u5408\u7269\u5177\u6709FGFR\u548cRET\u53cc\u9776\u70b9\u6291\u5236\u6d3b\u6027\u9ad8\uff0cKDR\u6d3b\u6027\u76f8\u5bf9\u8f83\u4f4e\u7684\u4f18\u70b9\uff0c\u5728\u4eba\u80ba\u764c\u7ec6\u80de\u682aNCI-H1581 \u3001\u80c3\u764c\u7ec6\u80de\u682aSNU16\u53caRET\u4f9d\u8d56\u6027\u654f\u611f\u7ec6\u80de\u682aBaF3-CCDC6-Ret\u53ca\u7a81\u53d8\u578b\u5747\u663e\u793a\u51fa\u4e86\u5f88\u5f3a\u7684\u6291\u5236\u6d3b\u6027\uff0c\u4e14\u836f\u4ee3\u6570\u636e\u8868\u660e\u8be5\u7c7b\u5316\u5408\u7269\u5177\u6709\u6210\u836f\u6027\u3002<\/span><\/p>\n

\u4e13\u5229WO 2018148863\u6d89\u53ca\u4e00\u79cdN-\uff085-\u5417\u7433\u4ee3\u567b\u5511-2-\u57fa\uff09\u7532\u9170\u80fa\u7c7b\u5316\u5408\u7269\u53ca\u5176\u5236\u5907\u65b9\u6cd5\u548c\u7528\u9014\u3002\u8be5\u7c7b\u5316\u5408\u7269\u5177\u6709\u4fc3\u8fdbA\u03b2\u6e05\u9664\u548c\u6291\u5236Tau\u86cb\u767d\u8fc7\u5ea6\u78f7\u9178\u5316\u7684\u4f5c\u7528\uff0c\u5e76\u5177\u6709\u6539\u5584APP\/PS1\u8f6c\u57fa\u56e0AD\u6a21\u578b\u5c0f\u9f20\u7684\u8bb0\u5fc6\u529b\u635f\u4f24\u7684\u4f5c\u7528\uff0c\u6709\u671b\u5f00\u53d1\u4e3a\u65b0\u578b\u6297\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u836f\u7269\u3002<\/span><\/p>\n

\u88685\uff1a\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u516c\u5f00\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7<\/span><\/strong><\/p>\n

\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.08.15-2018.09.14\uff09\"<\/p>\n

\u5176\u4ed6\u56fd\u5185\u673a\u6784<\/span><\/strong><\/p>\n

\u56db\u5ddd\u79d1\u4f26\u535a\u6cf0\u751f\u7269\u533b\u836f\u4e13\u5229WO 2018149284\u6d89\u53caASK1\u6291\u5236\u5242\u3001\u5305\u542b\u5176\u7684\u836f\u7269\u7ec4\u5408\u7269\u3001\u5176\u5236\u5907\u65b9\u6cd5\u548c\u4e2d\u95f4\u4f53\u53ca\u5176\u7528\u4e8e\u9884\u9632\u6216\u6cbb\u7597ASK1\u4ecb\u5bfc\u7684\u75be\u75c5\u7684\u7528\u9014\uff0c\u5305\u62ec\u6162\u6027\u8102\u80aa\u6027\u548c\u7ea4\u7ef4\u6027\u53d8\u6027\u5f15\u8d77\u7684\u75c5\u75c7\u548c\u75be\u75c5\uff08NAFLD\u6216NASH\uff09\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u547c\u5438\u9053\u75be\u75c5\u3001\u708e\u6027\u75be\u75c5\u3001\u6162\u6027\u80be\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u3001\u4ee3\u8c22\u969c\u788d\u3001\u5fc3\u810f\u3001\u5927\u8111\u4ee5\u53ca\u80be\u810f\u7684\u5c40\u90e8\u7f3a\u8840\u548c\u518d\u704c\u6ce8\u540e\u7684\u5668\u5b98\u635f\u4f24\u4ee5\u53ca\u795e\u7ecf\u53d8\u6027\u75be\u75c5\u7b49\u3002<\/span><\/p>\n

\u4e0a\u6d77\u957f\u68ee\u836f\u4e1a\u4e13\u5229WO 2018153326\u6d89\u53ca\u4e00\u79cd\u78fa\u9170\u80bc\u7c7b\u5316\u5408\u7269\u548c\u5176\u4f5c\u4e3a\u836f\u7269\u7528\u4e8e\u6cbb\u7597\u4e59\u578b\u809d\u708e\u7684\u7528\u9014\u3002<\/span><\/p>\n

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\u6c5f\u82cf\u8c6a\u68ee\u5236\u836f\u4e13\u5229WO 2018157856\u6d89\u53ca\u9170\u80fa\u7c7b\u884d\u751f\u7269\u4f5c\u4e3aASK1\u6291\u5236\u5242\u7528\u4e8e\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u708e\u75c7\u3001\u81ea\u8eab\u514d\u75ab\u548c\u4ee3\u8c22\u6027\u75be\u75c5\u7684\u6f5c\u5728\u6cbb\u7597\u3002<\/span><\/p>\n

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\u53c2\u8003\u8d44\u6599:<\/span><\/p>\n

1. Clarivate Analytics Cortellis\u6570\u636e\u5e93, \u68c0\u7d22\u65e5\u671f: 2018\u5e749\u670817\u65e5.<\/span><\/p>\n

2. \u4e07\u8c61\u4e91\u6570\u636e\u5e93\uff0c\u68c0\u7d22\u65e5\u671f: 2018\u5e749\u670820\u65e5.<\/span><\/p>\n


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