{"id":62640,"date":"2018-11-30T01:00:00","date_gmt":"2018-12-07T03:19:42","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/b7ba4187e5\/"},"modified":"2018-12-07T11:19:45","modified_gmt":"2018-12-07T03:19:45","slug":"b7ba4187e5","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/62640\/","title":{"rendered":"\u836f\u5ba1\u8bba\u575b | \u5bf9\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u6dcb\u5df4\u7ec6\u80de\u6cbb\u7597\u6dcb\u5df4\u9020\u8840\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u8003\u8651"},"content":{"rendered":"
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B\u7ec6\u80de\u6dcb\u5df4\u7624\u662f\u4e00\u7ec4\u8d77\u6e90\u4e8eB\u6dcb\u5df4\u7ec6\u80de\u7684\u5f02\u8d28\u6027\u80bf\u7624\uff0c\u5177\u6709\u4e0d\u540c\u5206\u5b50\u7279\u6027\u548c\u9884\u540e\uff0c\u4e34\u5e8a\u75c5\u7406\u4e9a\u578b\u53ef\u5206\u4e3a\u4fb5\u88ad\u6027\uff08\u751f\u957f\u5feb\u901f\u6216\u9ad8\u7b49\u7ea7\uff0c\u5982\u5f25\u6563\u6027\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\uff09\u548c\u60f0\u6027\uff08\u751f\u957f\u7f13\u6162\u6216\u4f4e\u7b49\u7ea7\uff0c \u5982FL\uff0cCLL\u7b49\uff09\u3002\u4e3a\u4fdd\u62a4\u53d7\u8bd5\u8005\u6743\u76ca\uff0cCAR-T\u7ec6\u80de\u4e34\u5e8a\u7814\u7a76\u5e94\u9009\u62e9\u524d\u671f\u8fdb\u8fc7\u89c4\u8303\u6cbb\u7597\uff0c\u76ee\u524d\u7f3a\u4e4f\u6709\u6548\u6cbb\u7597\u624b\u6bb5\u7684\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u60a3\u8005\u4e2d\u5f00\u5c55\u3002\u7531\u4e8e\u4e0d\u540c\u75c5\u7406\u4e9a\u578b\u60a3\u8005\u53ef\u9009\u62e9\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u548c\u75be\u75c5\u8fdb\u5c55\u7279\u5f81\u4e0d\u540c\uff0c\u9488\u5bf9\u4fb5\u88ad\u6027\u75be\u75c5\u5e94\u8003\u8651\u81f3\u5c11\u4e8c\u7ebf\u6cbb\u7597\u5931\u8d25\u540e\u7684\u60a3\u8005\u3001\u539f\u53d1\u8010\u836f\u3001\u79fb\u690d\u540e\u590d\u53d1\u7684\u60a3\u8005\u3002\u9488\u5bf9\u60f0\u6027\u5165\u9009\u6761\u4ef6\u53ef\u4ee5\u66f4\u4e25\u683c\uff0c\u5e94\u8003\u8651\u5927\u4e8e\u7b49\u4e8e\u4e09\u7ebf\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u3002CD20\u9633\u6027\u60a3\u8005\u5e94\u63a5\u53d7\u8fc7\u76f8\u5e94\u7684\u9776\u5411\u6cbb\u7597\u3002<\/p>\n

            <\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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<\/p>\n

\u6211\u56fd\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u6cbb\u7597\u9009\u62e9\u5728\u8fd1\u671f\u5df2\u6709\u8f83\u5927\u8fdb\u5c55\uff0c\u591a\u79cd\u6cbb\u7597\u836f\u7269\uff0c\u5305\u62ecCD38\u5355\u6297\u76ee\u524d\u5df2\u6279\u51c6\u4e0a\u5e02\u30022017\u4e2d\u56fd\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u8bca\u6cbb\u6307\u5357\u5df2\u5c06\u787c\u66ff\u4f50\u7c73\uff0c\u6c99\u5229\u5ea6\u80fa\u548c\u6765\u90a3\u5ea6\u80fa\u4f5c\u4e3a\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u5173\u952e\u836f\u7269\u3002<\/p>\n

       <\/p>\n

\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u75c5\u60c5\u8fdb\u5c55\u901a\u5e38\u8f83\u6162\uff0cCAR-T\u4f5c\u4e3a\u4e00\u79cd\u6f5c\u5728\u98ce\u9669\u8f83\u9ad8\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7597\u6cd5\uff0c\u5728\u65e0\u5145\u5206\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u652f\u6301\u524d\uff0c\u5e94\u653e\u5728\u7ecf\u8fc7\u6807\u51c6\u6cbb\u7597\u540e\u7684\u672b\u7ebf\u6cbb\u7597\u66f4\u4e3a\u5408\u9002\uff0c\u5373\u5728\u86cb\u767d\u9176\u6291\u5236\u5242\u53ca\u514d\u75ab\u8c03\u8282\u5242\u6cbb\u7597\u65e0\u6548\u3001\u5728\u63a5\u53d7\u8fc7\u4e09\u7ebf\u4ee5\u4e0a\u6b63\u89c4\u7684\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1\u96be\u6cbb\u60a3\u8005\u3002<\/p>\n

       <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8bd5\u9a8c\u8bbe\u8ba1<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n

\u9f13\u52b1\u7533\u8bf7\u4eba\u5728\u5173\u952e\u7684\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u91c7\u7528\u968f\u673a\u5bf9\u7167\u8bbe\u8ba1\uff0c\u5982\u679c\u968f\u673a\u5bf9\u7167\u7814\u7a76\u4e0d\u53ef\u884c\uff0c\u7533\u8bf7\u4eba\u5e94\u8bf4\u660e\u7406\u7531\u5e76\u89e3\u91ca\u62df\u91c7\u7528\u7684\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u5408\u7406\u6027\u3002<\/p>\n

       <\/p>\n

\u5f53\u5173\u952e\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u4e3a\u975e\u968f\u673a\u5bf9\u7167\u7814\u7a76\uff0c\u4e14\u7edf\u8ba1\u5b66\u8bbe\u8ba1\u91c7\u7528\u76ee\u6807\u503c\u6cd5\u65f6\uff0c\u4e3b\u8981\u7597\u6548\u6307\u6807\u7684\u53ef\u4fe1\u533a\u95f4\u4e0b\u9650\uff08\u4f8b\u598295%\u53ef\u4fe1\u533a\u95f4\u4e0b\u9650\uff09\u4e0d\u5e94\u4f4e\u4e8e\u73b0\u6709\u6cbb\u7597\u65b9\u6cd5\u5728\u76ee\u6807\u9002\u5e94\u75c7\u4eba\u7fa4\u4e2d\u7684\u6709\u6548\u7387\uff0c\u5e76\u63d0\u4f9b\u76ee\u6807\u503c\u8bbe\u5b9a\u7684\u4e34\u5e8a\u4f9d\u636e\u548c\u76f8\u5173\u7814\u7a76\u8d44\u6599\u3002\u9776\u503c\uff08target\uff09\u7684\u8bbe\u5b9a\u5e94\u6839\u636e\u63a2\u7d22\u6027\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7814\u7a76\u7ed3\u679c\u3001\u56fd\u5185\u5916\u540c\u7c7b\u4ea7\u54c1\u53ca\u5176\u5b83\u6cbb\u7597\u4ea7\u54c1\u5df2\u7ecf\u53d6\u5f97\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u3001\u73b0\u6709\u6cbb\u7597\u7684\u4e34\u5e8a\u7597\u6548\u7b49\u7efc\u5408\u8003\u8651\u3002<\/p>\n

       <\/p>\n

CAR-T\u7ec6\u80de\u662f\u7ecf\u8fc7\u57fa\u56e0\u4fee\u9970\u7684\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\uff0c\u53ef\u80fd\u5bfc\u81f4\u60a3\u8005\u51fa\u73b0\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\uff08CRS\uff09\u3001\u795e\u7ecf\u6bd2\u6027\u7b49\u591a\u79cd\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff0c\u56e0\u6b64\uff0c\u5173\u952e\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u7684\u53d7\u8bd5\u8005\u89c4\u6a21\u5728\u6ee1\u8db3\u57fa\u4e8e\u7597\u6548\u7684\u7edf\u8ba1\u5b66\u5047\u8bbe\u7684\u524d\u63d0\u4e0b\uff0c\u8fd8\u5e94\u63d0\u4f9b\u66b4\u9732CAR-T\u7ec6\u80de\u4ea7\u54c1\u5728\u53d7\u8bd5\u8005\u4e2d\u7684\u5b89\u5168\u6027\u98ce\u9669\u7684\u8f83\u5145\u5206\u7684\u6570\u636e\u3002<\/p>\n

       <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7597\u6548\u7ec8\u70b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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<\/p>\n

\u751f\u5b58\u65f6\u95f4\u662f\u8bc4\u4ef7\u6076\u6027\u80bf\u7624\u6cbb\u7597\u836f\u7269\u7597\u6548\u7684\u91d1\u6807\u51c6\uff0c\u800c\u5bf9\u4e8e\u751f\u5b58\u671f\u8f83\u957f\u7684\u7624\u79cd\u6216\u540e\u7eed\u6cbb\u7597\u5e72\u9884\u8f83\u591a\u7684\u60c5\u51b5\uff0c\u9009\u62e9\u5408\u7406\u7684\u66ff\u4ee3\u7ec8\u70b9\u4e5f\u5177\u6709\u5176\u53ef\u884c\u6027\u3002<\/p>\n

       <\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u6025\u6027B\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08B-ALL\uff09<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ee\u524d\uff0c\u5bf9\u4e8e\u590d\u53d1\u96be\u6cbb\u7684B-ALL\u7684CAR-T\u7ec6\u80de\u6cbb\u7597\uff0c\u56fd\u9645\u4e0a\u901a\u5e38\u91c7\u7528\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4f5c\u4e3a\u7597\u6548\u7684\u8bc4\u4f30\u6807\u51c6\uff0c\u8fd9\u4e00\u65b9\u9762\u662f\u56e0\u4e3aCAR-T\u7ec6\u80de\u6cbb\u7597\u7684\u76ee\u6807\u662f\u957f\u671f\u6301\u7eed\u7f13\u89e3\uff0c\u53e6\u4e00\u65b9\u9762\u5219\u662f\u80bf\u7624\u7f13\u89e3\u4e0e\u751f\u5b58\u65f6\u95f4\u7684\u76f8\u5173\u6027\u3002\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53ef\u4ee5\u5728\u82e5\u5e72\u4e0d\u540c\u65f6\u95f4\u70b9\u5bf9\u53d7\u8bd5\u8005\u7684\u7597\u6548\u6307\u6807\u8fdb\u884c\u8bc4\u4ef7\u3002\u4e3a\u4e86\u66f4\u5ba2\u89c2\u5730\u53cd\u5e94CAR-T\u7ec6\u80de\u4ea7\u54c1\u7684\u7597\u6548\u53ca\u53d7\u8bd5\u8005\u7684\u9884\u540e\uff0c\u4e3b\u8981\u7597\u6548\u6307\u6807\u7684\u8bc4\u4ef7\u65f6\u95f4\u4e0d\u5e94\u77ed\u4e8e\u4e09\u4e2a\u6708\uff0c\u540c\u65f6\u5e94\u5bf9CAR-T\u7ec6\u80de\u4ea7\u54c1\u5728\u53d7\u8bd5\u8005\u4e2d\u7684\u957f\u671f\u7597\u6548\u548c\u5b89\u5168\u6027\u8fdb\u884c\u6301\u7eed\u968f\u8bbf\u3002\u6b64\u5916\uff0c\u9664ORR\u5916\uff0c\u5efa\u8bae\u540c\u65f6\u89c2\u5bdf\u53d7\u8bd5\u8005\u7684\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DOR\uff09\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\uff08PFS\uff09\u548c\u603b\u751f\u5b58\u65f6\u95f4\uff08OS\uff09\u7b49\u7597\u6548\u6307\u6807\uff0c\u4ee5\u5168\u9762\u8bc4\u4ef7\u53d7\u8bd5\u8005\u63a5\u53d7CAR-T\u7ec6\u80de\u6cbb\u7597\u540e\u7684\u4e34\u5e8a\u83b7\u76ca\u60c5\u51b5\u3002<\/p>\n

       <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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B\u7ec6\u80de\u6dcb\u5df4\u7624<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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B\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u4e3b\u8981\u77ed\u671f\u7597\u6548\u8bc4\u4f30\u6307\u6807\u53ef\u91c7\u7528ORR\uff0c\u8bc4\u4ef7\u65f6\u95f4\u4e0d\u5e94\u77ed\u4e8e\u4e09\u4e2a\u6708\u3002\u5176\u4ed6\u7597\u6548\u6307\u6807\u5e94\u5305\u62ec\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DOR\uff09\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\uff08PFS\uff09\u548c\u603b\u751f\u5b58\u65f6\u95f4\uff08OS\uff09\u7b49\u3002<\/p>\n

       <\/p>\n

\u6b64\u5916\uff0c\u57fa\u4e8e\u76ee\u524d\u5df2\u7ecf\u83b7\u6279\u4e0a\u5e02\u7684CAR-T\u7ec6\u80de\u6cbb\u7597B\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u6548\u679c\uff0c\u7ed3\u5408\u4e0d\u540c\u75c5\u7406\u4e9a\u578b\u4e0d\u5c3d\u76f8\u540c\u7684\u6cbb\u7597\u76ee\u6807\uff0c\u53ef\u4ee5\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u8fdb\u4e00\u6b65\u6536\u96c6\u5bf9\u4e34\u5e8a\u8bc4\u4ef7\u66f4\u6709\u610f\u4e49\u7684\u77ed\u671f\u7597\u6548\u6307\u6807\u3002\u5176\u4e2d\uff0c\u4fb5\u88ad\u6027\u75be\u75c5\u8fdb\u5c55\u5feb\uff0c\u5982\u7ecf\u6cbb\u7597\u540e\u672a\u80fd\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u5219\u53ef\u80fd\u4e8e\u77ed\u671f\u5185\u590d\u53d1\uff0c\u60a3\u8005\u6700\u7ec8\u7684\u751f\u5b58\u83b7\u76ca\u4e0d\u663e\u8457\u3002\u56e0\u6b64\uff0c\u5bf9\u4e8e\u5982\u5f25\u6563\u6027\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\u7b49\u4fb5\u88ad\u6027\u75be\u75c5\u4e9a\u578b\uff0c\u5e94\u91cd\u70b9\u5173\u6ce8\u5b8c\u5168\u7f13\u89e3\u7387\uff0c\u8bc4\u4ef7\u65f6\u95f4\u81f3\u5c11\u4e3a3\u4e2a\u6708\u3002<\/p>\n

       <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n

\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u76ee\u524d\u5e38\u7528\u7684\u77ed\u671f\u7597\u6548\u8bc4\u4ef7\u6307\u6807\u4e3a\u6839\u636e\u56fd\u9645\u9aa8\u9ad3\u7624\u5de5\u4f5c\u7ec4\uff08IMWG\uff09\u7684\u7597\u6548\u6807\u51c6\u8bc4\u4f30\u7684ORR\u3002\u8003\u8651\u5230\u8be5\u75be\u75c5\u8fdb\u5c55\u53ef\u80fd\u8f83\u6162\uff0cCAR-T\u7ec6\u80de\u6cbb\u7597\u7684\u77ed\u671f\u7597\u6548\u8bc4\u4ef7\u65f6\u95f4\u81f3\u5c11\u4e3a3\u4e2a\u6708\u4ee5\u4e0a\u3002\u5176\u4ed6\u7684\u7597\u6548\u6307\u6807\u53ef\u5305\u62ecMRD\u9634\u6027\u7684\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u603b\u751f\u5b58\u671f\uff08OS\uff09\u7b49\u3002<\/p>\n

       <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u514d\u75ab\u539f\u6027\u548c\u63a2\u7d22\u6027\u7814\u7a76<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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CAR-T\u7ec6\u80de\u4ea7\u54c1\u662f\u4e00\u7c7b\u6d3b\u7ec6\u80de\u4ea7\u54c1\uff0c\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u70b9\u4e0e\u4f20\u7edf\u7684\u5316\u5b66\u6216\u751f\u7269\u836f\u7269\u6709\u660e\u663e\u5dee\u5f02\uff0c\u56de\u8f93\u4f53\u5185\u540e\u53ef\u80fd\u589e\u6b96\u5e76\u5b58\u6d3b\u8f83\u957f\u65f6\u95f4\u3002\u7533\u8bf7\u4eba\u5e94\u6839\u636eCAR-T\u7ec6\u80de\u4ea7\u54c1\u7684\u7c7b\u578b\uff0c\u5728\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u4e2d\u5236\u5b9a\u79d1\u5b66\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u68c0\u6d4b\u65b9\u6cd5\u3002\u5982\u679c\u4e00\u79cd\u65b9\u6cd5\u4e0d\u80fd\u5b8c\u5168\u53cd\u6620\u7ec6\u80de\u5728\u4f53\u5185\u7684PK\u7279\u6027\uff0c\u5efa\u8bae\u7533\u8bf7\u4eba\u91c7\u7528\u591a\u79cd\u68c0\u6d4b\u6280\u672f\uff08\u5982qPCR\u548c\u6d41\u5f0f\u7ec6\u80de\u6cd5\uff09\u5145\u5206\u7814\u7a76\u7ec6\u80de\u5728\u4f53\u5185\u7684\u589e\u6b96\u548c\u5b58\u6d3b\u60c5\u51b5\u3002<\/p>\n

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\u56fd\u5185\u5916\u4e34\u5e8a\u8bd5\u9a8c\u7ecf\u9a8c\u663e\u793a\uff0cCAR-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\uff0c\u662f\u7ecf\u57fa\u56e0\u4fee\u9970\u7684\uff0c\u53ef\u80fd\u5bfc\u81f4\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u3001\u795e\u7ecf\u6bd2\u6027\u3001\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\uff08TLS\uff09\u3001\u5de8\u566c\u7ec6\u80de\u6fc0\u6d3b\u7efc\u5408\u5f81\u7b49\u4e0d\u826f\u53cd\u5e94\u3002\u8fd1\u5e74\u6765\uff0c\u968f\u7740CRISPR\/Cas9\u7b49\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5728\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u7684\u5e94\u7528\uff0c\u65b0\u4ea7\u54c1\u548c\u65b0\u6280\u672f\u4e5f\u7ed9\u60a3\u8005\u5e26\u6765\u5f88\u591a\u6f5c\u5728\u7684\u5b89\u5168\u6027\u98ce\u9669\uff0c\u4f8b\u5982\u8131\u9776\u6548\u5e94\u3001\u81f4\u7624\u6027\u7b49\u3002\u56e0\u6b64\uff0c\u5b89\u5168\u6027\u98ce\u9669\u7684\u63a7\u5236\u65b9\u6848\u662f\u8861\u91cfCAR-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u548c\u5b9e\u65bd\u80fd\u529b\u6700\u5173\u952e\u7684\u8003\u8651\u56e0\u7d20\u4e4b\u4e00\u3002<\/p>\n


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[1] Tang J, Hubbard-Lucey VM, Pearce L, et al. The global landscape of cancer cell therapy[J]. Nat Rev Drug Discov 2018;17(7):465-466. <\/span><\/strong><\/p>\n

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[2] Gou L, Gao J, Yang H, et al. The landscape of CAR T-cell therapy in the United States and China: a comparative analysis[J]. Int J Cancer 2018; 10.1002\/ijc.31924. <\/span><\/strong><\/p>\n

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[3] \u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u8840\u6db2\u80bf\u7624\u4e13\u4e1a\u59d4\u5458\u4f1a. \u4e2d\u56fd\u6210\u4eba\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u8bca\u65ad\u4e0e\u6cbb\u7597\u6307\u5357(2016\u5e74\u7248)[J]. \u4e2d\u534e\u8840\u6db2\u5b66\u6742\u5fd7, 2016, 37(10):837-845.<\/span><\/strong><\/p>\n

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[4] \u4e2d\u534e\u533b\u5b66\u4f1a\u513f\u79d1\u5b66\u5206\u4f1a\u8840\u6db2\u5b66\u7ec4. \u513f\u7ae5\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u8bca\u7597\u5efa\u8bae\uff08\u7b2c\u56db\u6b21\u4fee\u8ba2\uff09[J].\u4e2d\u534e\u513f\u79d1\u6742\u5fd7.2014,52(9):641-644.<\/span><\/strong><\/p>\n

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[5] \u77f3\u8fdc\u51ef,\u5b59\u71d5,\u5218\u5f64\u534e. \u4e2d\u56fd\u6076\u6027\u6dcb\u5df4\u7624\u8bca\u7597\u89c4\u8303(2015\u5e74\u7248)[J] \u4e2d\u534e\u80bf\u7624\u6742\u5fd7.2015,37(2):148-158.<\/span><\/strong><\/p>\n

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[6] \u4e2d\u534e\u533b\u5b66\u4f1a\u513f\u79d1\u5b66\u5206\u4f1a\u8840\u6db2\u5b66\u7ec4,\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u513f\u79d1\u4e13\u4e1a\u59d4\u5458\u4f1a,\u300a\u4e2d\u534e\u513f\u79d1\u6742\u5fd7\u300b\u7f16\u8f91\u59d4\u5458\u4f1a.\u513f\u7ae5\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u8bca\u7597\u5efa\u8bae[J].\u4e2d\u534e\u513f\u79d1\u6742\u5fd7,2011,49(3):186-192.<\/span><\/strong><\/p>\n

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[7] \u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u8840\u6db2\u79d1\u533b\u5e08\u5206\u4f1a,\u4e2d\u534e\u533b\u5b66\u4f1a\u8840\u6db2\u5b66\u5206\u4f1a,\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u4e13\u4e1a\u59d4\u5458\u4f1a.\u4e2d\u56fd\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u8bca\u6cbb\u6307\u5357(2017\u5e74\u4fee\u8ba2)[J].\u4e2d\u534e\u5185\u79d1\u6742\u5fd7,2017,56(11):866-870.<\/span><\/strong><\/p>\n

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[8] Neelapu S.S., Tummala S, Kebriaei P, et al. Chimeric antigen receptor T-cell therapy-assessment and management of toxicities[J]. Nature Reviews Clinical Oncology, 2017, 15(1).<\/span><\/strong><\/p>\n

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[9] Brudno J.N., Kochenderfer J.N.. Toxicities of chimeric antigen receptor T cells: recognition and management.[J]. Blood, 2016, 127(26):3321.<\/span><\/strong><\/p>\n

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[10] Neelapu S.S., Tummala S., Kebriaei P, et al. Toxicity management after chimeric antigen receptor T cell therapy: one size does not fit “ALL”[J]. Nature Reviews Clinical Oncology, 2018, 15(4).<\/span><\/strong><\/p>\n

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[11] Lee DW, Gardner R, Porter DL, et al. Current concepts in the diagnosis and management of cytokine release syndrome[J].Blood.2014;124(2):188-195.<\/span><\/strong><\/p>\n

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[12] Maude, S.L., T.W. Laetsch, J. Buechner, et al., Tisagenlecleucel in Children and Young Adults with B- Lymphoblastic Leukemia[J]. N Engl J Med, 2018. 378(5): 439-448.<\/span><\/strong><\/p>\n

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[13] Neelapu, S.S., F.L. Locke, N.L. Bartlett, et al., Axicabtagene Ciloleucel CAR T- Therapy in Refractory Large B- Lymphoma[J]. N Engl J Med, 2017. 377(26): 2531-2544.<\/span><\/strong><\/p>\n

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[14] FDA. Guidance for Industry Gene Therapy Clinical Trials \u2013 Observing Subjects for Delayed AdverseEvents[EB\/OL].(2006-11)https:\/\/www.fda.gov\/downloads\/biologicsbloodvaccines\/guidancecomplianceregulatoryinformation\/guidances\/cellularandgenetherapy\/ucm078719.pdf<\/span><\/strong><\/p>\n

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[15] EMA. Follow-up of patients administered with gene therapy medicinal products [EB\/OL].(2010-01-05)https:\/\/www.ema.europa.eu\/follow-patients-administered-gene-therapy-medicinal-products<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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