{"id":63905,"date":"2018-10-15T01:00:00","date_gmt":"2018-12-07T03:32:49","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/5a136859db\/"},"modified":"2018-12-07T11:32:54","modified_gmt":"2018-12-07T03:32:54","slug":"5a136859db","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/63905\/","title":{"rendered":"\u524d\u6cbf\u8d44\u8baf | \u805a\u7126\u7b2c 22 \u5c4a\u56fd\u9645 MDS \u5927\u4f1a\uff0c\u5171\u4eab\u5e15\u91d1\u68ee\u7814\u7a76\u65b0\u8fdb\u5c55"},"content":{"rendered":"
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\u7b2c 22 \u5c4a\u56fd\u9645\u5e15\u91d1\u68ee\u53ca\u8fd0\u52a8\u969c\u788d\u5927\u4f1a(International Congress of Parkinson\u2019s<\/span> Disease and Movement Disorders\uff0cMDS)\u5df2\u4e8e 2018 \u5e74 10 \u6708 5-9 \u65e5\u5728\u4e2d\u56fd\u9999\u6e2f\u53ec\u5f00\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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<\/span><\/p>\n

\u8ba9\u6211\u4eec\u4e00\u8d77\u8d70\u8fdb\u672c\u6b21\u4f1a\u8bae\uff0c\u9886\u7565\u5e15\u91d1\u68ee\u75c5\u6700\u524d\u6cbf\u7684\u8d44<\/span>\u8baf\u3002<\/span><\/p>\n

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<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f57\u66ff\u9ad8\u6c40\u901a\u8fc7\u9776\u5411\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e0a\u7684 <\/strong><\/p>\n

5-\u7f9f\u8272\u80fa 1A \u53d7\u4f53\u4fdd\u62a4\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
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<\/span><\/p>\n

\u65e2\u5f80<\/span>\u66fe\u62a5\u9053\uff0c\u523a\u6fc0\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e0a 5-\u7f9f\u8272\u80fa 1A\uff085-hydroxytryptamine receptor 1A\uff0c5-HT 1A\uff09\u53d7\u4f53\u53ef\u4fc3\u8fdb\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u589e\u6b96\uff0c\u5e76\u4e0a\u8c03\u6297\u6c27\u5316\u5206\u5b50\u91d1\u5c5e\u786b\u86cb\u767d\uff08Metallothionein\uff0cMT\uff09\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/span><\/p>\n

\u591a\u5df4\u80fa\u53d7\u4f53\u6fc0\u52a8\u5242\u7f57\u66ff\u9ad8\u6c40\u4e5f\u5177\u6709 5-HT 1A \u6fc0\u52a8\u5242\u7279\u6027\u3002\u65e5\u672c\u5b66\u8005 Masato Asanuma \u7b49\u91c7\u7528\u539f\u4ee3\u57f9\u517b\u7ec6\u80de\u548c\u5e15\u91d1\u68ee\u75c5\u5c0f\u9f20\u5206\u6790\u7f57\u66ff\u9ad8\u6c40\u7684\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u53ca\u661f\u5f62\u80f6\u8d28\u7ec6\u80de 5-HT 1A \u53d7\u4f53\u5728\u836f\u7269\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u4e2d\u7684\u53c2\u4e0e\u60c5\u51b5\u3002<\/span><\/p>\n


<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7814\u7a76\u8005\u9996\u5148\u5728 Sprague-Dawey \u5927\u9f20\u598a\u5a20 15 \u5929\u65f6\uff0c\u4ece\u5927\u9f20\u80da\u80ce\u7684\u4e2d\u8111\u548c\u7eb9\u72b6\u4f53\u4e2d\u5236\u5907\u51fa\u539f\u4ee3\u57f9\u517b\u7684\u795e\u7ecf\u5143\u548c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\uff0c\u7136\u540e\u5c06\u57f9\u517b\u7684\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7528\u7f57\u66ff\u9ad8\u6c40\uff081\u03bcM\uff09\u548c\/\u6216 5-HT 1A \u62ee\u6297\u5242 WAY100635\uff0810nM\uff09\u5904\u7406 6 \u5c0f\u65f6\u6216 24 \u5c0f\u65f6\uff0c\u5206\u522b\u8bc4\u4f30 NF-E2 \u76f8\u5173\u56e0\u5b50 2(Nuclear factor E2 related factor-2\uff0cNrf2) \u6838\u8f6c\u4f4d\u6216 MT \u8868\u8fbe\u3002<\/p>\n


<\/p>\n

\u7528\u6765\u81ea\u7f57\u66ff\u9ad8\u6c40\u548c\/\u6216 WAY-100635 \u5904\u7406\u7684\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7684\u6761\u4ef6\u57f9\u517b\u57fa\u5904\u7406\u4e2d\u8111\u795e\u7ecf\u5143 24 \u5c0f\u65f6\uff0c\u518d\u7528 6-\u7f9f\u57fa\u591a\u5df4\u80fa\uff086-hydroxydopamine\uff0c6-OHDA\uff09\u5904\u7406\uff0c\u5e76\u5bf9\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u6570\u91cf\u7684\u53d8\u5316\u8fdb\u884c\u68c0\u67e5\u3002\u7eb9\u72b6\u4f53\u5185\u6ce8\u5c04 6-OHDA \u5355\u4fa7\u635f\u4f24\u7684\u504f\u4fa7\u5e15\u91d1\u68ee\u75c5\u5c0f\u9f20\u6a21\u578b\u7528\u7f57\u66ff\u9ad8\u6c40\u5904\u7406 7 \u5929\u540e\u8fdb\u884c\u7ec4\u7ec7\u5316\u5b66\u5206\u6790\u3002<\/p>\n


<\/p>\n

\u7ed3\u679c\u53d1\u73b0\uff0c\u7f57\u66ff\u9ad8\u6c40\u6cbb\u7597\u8bf1\u5bfc\u661f\u5f62\u80f6\u8d28\u7ec6\u80de Nrf2 \u6838\u8f6c\u4f4d\u548c MT \u4e0a\u8c03\u3002\u7528\u6765\u81ea\u7f57\u66ff\u9ad8\u6c40\u5904\u7406\u7684\u661f\u5f62\u7ec6\u80de\u7684\u5bf9\u7167\u57f9\u517b\u57fa\u9884\u5904\u7406\u663e\u8457\u964d\u4f4e\u4e86 6-OHDA \u8bf1\u5bfc\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u6bd2\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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WAY100635 \u548c MT \u6297\u4f53\u5b8c\u5168\u963b\u65ad\u4e86\u8fd9\u4e9b\u4f5c\u7528\u3002\u7f57\u66ff\u9ad8\u6c40\uff080.5 mg\/kg\uff09\u589e\u52a0\u4e86\u7eb9\u72b6\u4f53\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e2d\u7684 MT \u8868\u8fbe\uff0c\u5e76\u4e14\u660e\u663e\u963b\u6b62\u4e86\u5e15\u91d1\u68ee\u75c5\u5c0f\u9f20\u9ed1\u8d28\u4e2d\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u51cf\u5c11\u3002\u7528 WAY00635\uff080.5 mg\/kg\uff09\u5171\u540c\u5904\u7406\u62b5\u6d88\u4e86\u7f57\u66ff\u9ad8\u6c40\u7684\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u3002<\/span>
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<\/p>\n

\u603b\u4e4b\uff0c\u8be5\u7814\u7a76\u8868\u660e\uff0c\u7f57\u66ff\u9ad8\u6c40\u901a\u8fc7\u9776\u5411\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e0a\u7684 5-HT 1A \u53d7\u4f53\u91ca\u653e MT\uff0c\u4ece\u800c\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\uff0c\u62ee\u6297\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u53d8\u6027\u3002<\/strong><\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u524d\u6cbf\u8d44\u8baf<\/section>\n<\/section>\n<\/section>\n
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\uff08\u6765\u81ea\u73b0\u573a\u4e13\u5bb6\u5e7b\u706f\uff09<\/span><\/p>\n


<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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PD \u836f\u7269\u8054\u5408\u6cbb\u7597\u8fdb\u5c55<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5e15\u91d1\u68ee\u75c5\uff08Parkinson\u2019s disease\uff0cPD\uff09\u6cbb\u7597\u65b9\u6cd5\u6709\u5f88\u591a\u79cd\uff0c\u836f\u7269\u6cbb\u7597\u662f\u5176\u4e2d\u4e00\u79cd\u3002PD \u6cbb\u7597\u836f\u7269\u5305\u62ec\uff1a\u5de6\u65cb\u591a\u5df4\u3001DA \u6fc0\u52a8\u5242\u3001MAO-B \u6291\u5236\u5242\u7b49\u3002\u836f\u7269\u6cbb\u7597\u5305\u62ec\u5355\u836f\u6cbb\u7597\u548c\u8054\u5408\u7528\u836f\uff0c\u5176\u4e2d\u5355\u836f\u6cbb\u7597\u9700\u8981\u589e\u5927\u7528\u836f\u5242\u91cf\uff0c\u4ece\u800c\u5bfc\u81f4\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u589e\u52a0\u3002\u5404\u79cd\u836f\u7269\u8054\u5408\u6cbb\u7597\uff0c\u540c\u65f6\u964d\u4f4e\u7528\u836f\u5242\u91cf\u6216\u8bb8\u662f\u4e00\u79cd\u597d\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n


<\/p>\n

Olivier \u5bf9 PD \u60a3\u8005\u8054\u5408\u7528\u836f\u8fdb\u884c\u4e86\u63a2\u7d22\uff0c\u76ee\u524d\u53ef\u80fd\u7684\u8054\u5408\u7528\u836f\u7b56\u7565\u5305\u62ec\uff1a<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u2460\u4e24\u8054\u836f\u7269\u6cbb\u7597\uff1a\u5de6\u65cb\u591a\u5df4+DA \u6fc0\u52a8\u5242\uff1b<\/p>\n


<\/p>\n

\u2461\u4e09\u8054\u836f\u7269\u6cbb\u7597\uff1a\u5de6\u65cb\u591a\u5df4+DA \u6fc0\u52a8\u5242+MAO-B \u6291\u5236\u5242\uff1b<\/p>\n


<\/p>\n

\u2462\u56db\u8054\u836f\u7269\u6cbb\u7597\uff1a\u5de6\u65cb\u591a\u5df4+DA \u6fc0\u52a8\u5242+MAO-B \u6291\u5236\u5242+\u91d1\u521a\u70f7\u80fa\uff1b<\/p>\n


<\/p>\n

\u2463\u4e94\u8054\u836f\u7269\u6cbb\u7597\uff1a\u5de6\u65cb\u591a\u5df4+DA \u6fc0\u52a8\u5242+MAO-B \u6291\u5236\u5242+\u91d1\u521a\u70f7\u80fa+\u8eab\u4f53\u953b\u70bc\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u6700\u4f73\u8054\u5408\u7528\u836f\u7b56\u7565\u4e3a\u75be\u75c5\u8c03\u8282\u6cbb\u7597\u836f\u7269\u548c\u75c7\u72b6\u63a7\u5236\u836f\u7269\u76f8\u8054\u5408\u3002<\/span>
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<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u524d\u6cbf\u8d44\u8baf<\/section>\n<\/section>\n<\/section>\n
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\uff08\u6765\u81ea\u73b0\u573a\u4e13\u5bb6\u5e7b\u706f\uff09<\/span>
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<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u808c\u5f20\u529b\u969c\u788d\u548c\u9707\u98a4\u836f\u7269\u7814\u7a76<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
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<\/p>\n

\u7279\u53d1\u6027\u9707\u98a4\uff08Essential tremor syndrome\uff0cET\uff09\u548c\u808c\u5f20\u529b\u969c\u788d\u90fd\u662f PD \u60a3\u8005\u5e38\u89c1\u7684\u8fd0\u52a8\u75c7\u72b6\uff0c\u7ed9\u60a3\u8005\u7684\u65e5\u5e38\u751f\u6d3b\u548c\u5de5\u4f5c\u5e26\u6765\u4e86\u5f88\u591a\u4e0d\u4fbf\u3002Tiago \u7814\u7a76\u8005\u5bf9\u808c\u5f20\u529b\u969c\u788d\u548c\u9707\u98a4\u7684\u836f\u7269\u8fdb\u884c\u4e86\u7efc\u8ff0\uff0c\u603b\u7ed3\u5982\u4e0b\uff1a<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Ø \u76ee\u524d\uff0c\u5c1a\u7f3a\u4e4f\u6709\u6548\u7684\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u4e3a\u808c\u5f20\u529b\u969c\u788d\u7684\u836f\u7269\u6cbb\u7597\u7b56\u7565\u63d0\u4f9b\u4f9d\u636e\uff1b<\/p>\n


<\/p>\n

Ø \u5df2\u63a8\u8350\u7684\u7b56\u7565\u90fd\u662f\u57fa\u4e8e\u4e13\u5bb6\u5171\u8bc6\u6216\u597d\u7684\u4e34\u5e8a\u5b9e\u8df5\u539f\u5219\uff1b<\/p>\n


<\/p>\n

Ø \u4e2a\u6027\u5316\u6cbb\u7597\u548c\u7075\u6d3b\u7684\u6cbb\u7597\u65b9\u6cd5\u5728 ET \u548c\u808c\u5f20\u529b\u969c\u788d\u7684\u6cbb\u7597\u4e2d\u663e\u5f97\u81f3\u5173\u91cd\u8981\uff1b<\/p>\n


<\/p>\n

Ø ET \u548c\u808c\u5f20\u529b\u969c\u788d\u7684\u53e3\u670d\u6cbb\u7597\uff0c\u4e3b\u8981\u9650\u5236\u56e0\u7d20\u662f\u526f\u4f5c\u7528\uff1b<\/p>\n


<\/p>\n

Ø  \u4e0d\u540c\u808c\u5f20\u529b\u969c\u788d\u75c5\u75c7\u7684\u75c5\u7406\u751f\u7406\u5b66\u77e5\u8bc6\u4f1a\u5bfc\u81f4\u66f4\u591a\u75be\u75c5\u7279\u5f02\u6027\u53e3\u670d\u6cbb\u7597\u65b9\u6cd5\u7684\u53d1\u73b0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u524d\u6cbf\u8d44\u8baf<\/section>\n<\/section>\n<\/section>\n
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\uff08\u6765\u81ea\u73b0\u573a\u4e13\u5bb6\u5e7b\u706f\uff09<\/span>
<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8089\u6bd2\u6746\u83cc\u6cbb\u7597\u808c\u5f20\u529b\u969c\u788d\u548c\u9707\u98a4\u7814\u7a76<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
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<\/p>\n

Raymond \u7814\u7a76\u8005\u5bf9\u8089\u6bd2\u6746\u83cc\u5728\u6cbb\u7597\u808c\u5f20\u529b\u969c\u788d\u548c\u9707\u98a4\u65b9\u9762\u8fdb\u884c\u4e86\u62a5\u9053\uff0c\u7ed3\u679c\u603b\u7ed3\u5982\u4e0b\uff1a<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n
\n

Ø  \u8089\u6bd2\u7d20\uff08Botulinum neurotoxin\uff0cBoNT\uff09\u7684\u5916\u5468\u6548\u5e94\u53ef\u80fd\u4f1a\u88ab\u808c\u5f20\u529b\u969c\u788d\u76f8\u5173\u673a\u5236\u8fdb\u884c\u4fee\u6539\uff1b<\/p>\n


<\/p>\n

Ø  BoNT \u662f\u5c40\u7076\u6027\u808c\u5f20\u529b\u969c\u788d\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\uff0c\u5bf9\u53e3\u4e0b\u988c\u808c\u5f20\u529b\u969c\u788d\u4e5f\u53ef\u80fd\u6709\u4e00\u5b9a\u7684\u7597\u6548\uff1b<\/p>\n


<\/p>\n

Ø  BoNT \u808c\u8089\u6ce8\u5c04\u80fd\u7f13\u89e3\u76f8\u5173\u75bc\u75db\uff0c\u5982\u795e\u7ecf\u6027\u75bc\u75db\uff1b<\/p>\n


<\/p>\n

Ø  BoNT \u5728\u7279\u53d1\u6027\u9707\u98a4\u65b9\u9762\u7684\u6548\u679c\u4e5f\u53ef\u80fd\u540c\u6837\u9002\u7528\u4e8e PD \u60a3\u8005\u7684\u9707\u98a4\uff1b<\/p>\n


<\/p>\n

Ø  BoNT \u7684\u7597\u6548\u53ef\u80fd\u901a\u8fc7\u808c\u7535\u63cf\u8bb0\u672f\uff08Electromyography\uff0cEMG\uff09\u7b49\u8fdb\u884c\u4f18\u5316\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\"\u524d\u6cbf\u8d44\u8baf<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

\uff08\u6765\u81ea\u73b0\u573a\u4e13\u5bb6\u5e7b\u706f\uff09<\/span>
<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
<\/section>\n
\n
\n
\n
\n

PD \u60a3\u8005\u5eb7\u590d\u8bad\u7ec3\u65b9\u6cd5\u7814\u7a76<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n

\u5eb7\u590d\u8bad\u7ec3\u662f PD \u7684\u4e00\u79cd\u6cbb\u7597\u65b9\u6cd5\uff0c\u5eb7\u590d\u8bad\u7ec3\u5305\u62ec\uff1a\u7269\u7406\u7597\u6cd5\u3001\u804c\u4e1a\u7597\u6cd5\u548c\u8bed\u97f3\u6cbb\u7597\u3002Colleen \u5bf9\u5eb7\u590d\u6cbb\u7597\u7684\u4f5c\u7528\u548c\u5eb7\u590d\u8bad\u7ec3\u65b9\u5f0f\u8fdb\u884c\u4e86\u7814\u7a76\uff1a<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n

\u2460\u7269\u7406\u7597\u6cd5\uff1a\u6e10\u8fdb\u5f0f\u963b\u529b\u8bad\u7ec3\u80fd\u591f\u964d\u4f4e\u60a3\u8005\u300c\u836f\u7269\u5173\u671f\u300dUPDRS \u8fd0\u52a8\u75c7\u72b6\u8bc4\u5206\uff0c\u589e\u52a0\u300c\u836f\u7269\u5173\u671f\u300d\u60a3\u8005\u7684\u808c\u8089\u529b\u91cf\u3002\u9ad8\u5f3a\u5ea6\u5e73\u677f\u8fd0\u52a8\u80fd\u591f\u964d\u4f4e\u590d\u53d1\u8fd0\u52a8\u75c7\u72b6\u60a3\u8005\u7684 UPDRS \u8fd0\u52a8\u75c7\u72b6\u8bc4\u5206\uff0c\u5e76\u589e\u5f3a\u60a3\u8005\u7684\u953b\u70bc\u80fd\u529b\u3002\u53e6\u5916\uff0c\u7269\u7406\u7597\u6cd5\u8fd8\u80fd\u589e\u5f3a\u60a3\u8005\u7684\u5e73\u8861\u548c\u8fd0\u52a8\u529f\u80fd\uff0c\u964d\u4f4e\u8dcc\u5012\u6b21\u6570\uff1b<\/p>\n


<\/p>\n

\u2461\u804c\u4e1a\u7597\u6cd5\uff1a\u53ef\u4ee5\u63d0\u9ad8\u60a3\u8005\u7684\u81ea\u6211\u611f\u77e5\uff0c\u6ee1\u8db3\u60a3\u8005\u65e5\u5e38\u6d3b\u52a8\u9700\u8981\uff1b<\/p>\n


<\/p>\n

\u2462\u8bed\u97f3\u7597\u6cd5\uff1a\u80fd\u591f\u63d0\u9ad8\u60a3\u8005\u7684\u58f0\u538b\u6c34\u5e73\u3001\u51cf\u5c11\u54bd\u90e8\u98df\u7269\u6b8b\u6e23\u3001\u7f13\u89e3\u541e\u54bd\u969c\u788d\u3001\u63d0\u9ad8\u4e0e\u541e\u54bd\u969c\u788d\u76f8\u5173\u7684\u751f\u6d3b\u8d28\u91cf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\"\u524d\u6cbf\u8d44\u8baf<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

\uff08\u6765\u81ea\u73b0\u573a\u4e13\u5bb6\u5e7b\u706f\uff09<\/span>
<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
<\/section>\n
\n
\n
\n
\n

\u57fa\u56e0\u7f16\u8f91\u7814\u7a76\u8fdb\u5c55<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

\u57fa\u56e0\u7f16\u8f91\u8fd1\u5e74\u6765\u53d1\u5c55\u5f97\u5982\u706b\u5982\u837c\uff0cTomas \u5bf9\u57fa\u56e0\u7f16\u8f91\u5728\u8fd0\u52a8\u969c\u788d\u4e2d\u7684\u7814\u7a76\u8fdb\u884c\u4e86\u62a5\u9053\uff1a<\/span>
<\/p>\n


<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n

Ø  CRISPR \/ Cas9 \u662f\u4e00\u79cd\u975e\u5e38\u901a\u7528\u7684\u5de5\u5177\uff1b<\/p>\n


<\/p>\n

Ø  \u5df2\u77e5\u7684 CRISPR \/ Cas9 \u57fa\u56e0\u7f16\u8f91\u53ea\u662f\u51b0\u5c71\u4e00\u89d2\uff1b<\/p>\n


<\/p>\n

Ø  \u8fd9\u4e9b CRISPR \/ Cas9 \u57fa\u56e0\u7f16\u8f91\u5de5\u5177\u73b0\u5df2\u6210\u719f\uff0c\u9002\u7528\u4e8e\u4f53\u5185\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08Central nervous system\uff0cCNS\uff09\u5e94\u7528\u548c\u8f6c\u5316\u7814\u7a76\uff1b<\/p>\n


<\/p>\n

Ø  \u4f46\u662f\uff0cCRISPR \/ Cas9 \u57fa\u56e0\u7f16\u8f91\u6280\u672f\u8fd8\u6709\u5f88\u5927\u7684\u6539\u8fdb\u7a7a\u95f4\u3002\u6bd4\u5982\uff1a\u5173\u4e8e CNS \u7684\u4f53\u5185\u6548\u7387\uff0c\u5728\u4f53\u5185\u7f16\u8f91\u548c\u53bb\u9664\u8131\u9776\u6548\u5e94\u3002\u76ee\u524d\uff0c\u8fd9\u65b9\u9762\u7684\u6539\u8fdb\u6b63\u5728\u8fdb\u884c\u4e2d\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
<\/section>\n
\n
\n
\n
\n

GBA-PD \u53ca\u5176\u4e2a\u4f53\u5316\u6cbb\u7597\u7814\u7a76<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

Nir \u5bf9\u5e15\u91d1\u68ee\u75c5\u8461\u8404\u7cd6\u8111\u82f7\u8102\u9176\u57fa\u56e0(Glucocerebrosidase-associated <\/span>Parkinson\u2019s<\/span>\uff0cGBA-PD)\u548c\u5176\u4e2a\u4f53\u5316\u6cbb\u7597\u8fdb\u884c\u4e86\u62a5\u9053\uff0c\u73b0\u603b\u7ed3\u5982\u4e0b\uff1a<\/span>
<\/p>\n


<\/p>\n

GBA-PD \u662f PD \u60a3\u8005\u4e2d\u4e00\u79cd\u66f4\u4e25\u91cd\u7684\u75be\u75c5\uff0c\u5177\u6709\u4ee5\u4e0b\u7279\u70b9\uff1a<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n

Ø  \u53d1\u75c5\u5e74\u9f84\u65e9\uff1b<\/p>\n


<\/p>\n

Ø  \u5feb\u901f\u8fdb\u5c55\uff1a\u59ff\u52bf\u4e0d\u7a33\u3001\u6b65\u6001\u7d0a\u4e71\uff1b\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u3001\u75f4\u5446\u75c7\uff1b\u5e7b\u89c9\uff1b\u5feb\u52a8\u773c\u7761\u7720\u884c\u4e3a\u969c\u788d\uff1b\u81ea\u4e3b\u795e\u7ecf\u7d0a\u4e71\u3002<\/p>\n


<\/p>\n

Ø  \u65e9\u671f\u8fd0\u52a8\u53cd\u5e94\u6ce2\u52a8<\/p>\n


<\/p>\n

Ø  \u9891\u7e41\u8fd0\u52a8\u969c\u788d\u3001<\/p>\n


<\/p>\n

Ø  \u9884\u671f\u5bff\u547d\u7f29\u77ed\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n

\u4e2a\u4f53\u5316\u6cbb\u7597\u662f GBA-PD \u7684\u4e00\u79cd\u6cbb\u7597\u65b9\u6cd5\u3002\u600e\u4e48\u5224\u65ad\u4e2a\u4f53\u5316\u6cbb\u7597\u662f\u5426\u5408\u7406\uff1f\u7814\u7a76\u8005\u8ba4\u4e3a\u8981\u5177\u5907\u4ee5\u4e0b\u6761\u4ef6\uff1a<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n

1. \u5982\u679c\u8be5\u6cbb\u7597\u65b9\u6cd5\u80fd\u51cf\u5c11\u526f\u4f5c\u7528\uff1b<\/p>\n


<\/p>\n

2. \u5ef6\u8fdf\u75f4\u5446\u548c\u7b2c\u4e00\u6b21\u8dcc\u5012\u7684\u53d1\u751f\uff1b<\/p>\n


<\/p>\n

3. \u6539\u5584\u6cbb\u7597\u6548\u679c\uff1b<\/p>\n


<\/p>\n

4. \u51cf\u5c11\u526f\u4f5c\u7528\u548c\u5e76\u53d1\u75c7\u7684\u53d1\u751f\u7387\uff1b<\/p>\n


<\/p>\n

5. \u5f71\u54cd\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
<\/section>\n
\n
\n
\n
\n

\u8bf1\u5bfc\u591a\u80fd\u5728 PD \u60a3\u8005\u4e2d\u7684\u5e94\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

Ryosuke \u5bf9\u8bf1\u5bfc\u591a\u529f\u80fd\uff08Induced pluripotent stem cells\uff0ciPS cells\uff09\u6cbb\u7597 PD \u60a3\u8005\u8fdb\u884c\u4e86\u62a5\u9053\u3002<\/p>\n


<\/p>\n

iPS \u7ec6\u80de\u5728 PD \u60a3\u8005\u79fb\u690d\u6cbb\u7597\u4e2d\u7684\u4f18\u52bf\u5305\u62ec<\/strong>\uff1a1. \u4e0e\u795e\u7ecf\u76f8\u6bd4\uff0c\u6ca1\u6709\u6216\u51e0\u4e4e\u6ca1\u6709\u4f26\u7406\u95ee\u9898\u30022. iPS \u7ec6\u80de\u6765\u6e90\u662f\u65e0\u9650\u7684 3. \u81ea\u4f53\u79fb\u690d\u7406\u8bba\u4e0a\u4e0d\u4f1a\u8bf1\u5bfc\u514d\u75ab\u53cd\u5e94\uff0c\u4e5f\u4e0d\u4f1a\u88ab\u6392\u65a5\u3002<\/p>\n


<\/p>\n

iPS \u7ec6\u80de\u5728 PD \u60a3\u8005\u79fb\u690d\u6cbb\u7597\u4e2d\u7684\u7f3a\u70b9\u5305\u62ec<\/strong>\uff1a1. \u53ef\u80fd\u4e0d\u4f1a\u53d1\u5c55\u6210\u4e3a\u6210\u719f\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u30022. \u53ef\u4ee5\u91cd\u73b0\u75be\u75c5\u8868\u578b\uff0c\u4f8b\u5982\u8def\u6613\u4f53\u5f62\u6210\u30023. \u6709\u6f5c\u5728\u7684\u81f4\u7624\u6027\u3002<\/p>\n


<\/p>\n

\u9664\u6b64\u4e4b\u5916\uff0c\u8bb2\u8005\u8fd8\u5c06\u81ea\u4f53 iPS \u79fb\u690d\u548c\u5f02\u4f53 iPS \u79fb\u690d\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u7ed3\u679c\u5982\u4e0b\uff1a<\/p>\n


<\/p>\n

\u81ea\u4f53 iPS \u79fb\u690d\u7684\u7279\u70b9\u6709<\/strong>\uff1a1. \u4e0d\u9700\u8981\u8fdb\u884c\u514d\u75ab\u6291\u5236\uff1b2. \u6bcf\u4e2a iPSC \u7684\u8d28\u91cf\u63a7\u5236\u5bf9\u4e8e\u786e\u4fdd\u5f88\u60a3\u8005\u5b89\u5168\u662f\u975e\u5e38\u5fc5\u8981\u7684\uff1b3. \u5e94\u68c0\u67e5 DA \u5206\u5316\u6548\u7387\u3002<\/p>\n


<\/p>\n

\u5f02\u4f53 iPS \u79fb\u690d\u7684\u7279\u70b9\u6709<\/strong>\uff1a1. \u514d\u75ab\u6291\u5236\u662f\u5fc5\u8981\u7684\uff1b2. \u9700\u8981\u8d28\u91cf\u63a7\u5236\uff1b3. DA \u5206\u5316\u6548\u7387\u5f97\u5230\u786e\u8ba4\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\"\u524d\u6cbf\u8d44\u8baf<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

\uff08\u6765\u81ea\u73b0\u573a\u4e13\u5bb6\u5e7b\u706f\uff09<\/span>
<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
<\/section>\n
\n
\n
\n
\n

\u4e0b\u4e00\u4ee3\u6d4b\u5e8f\u53ef\u4f5c\u4e3a\u808c\u5f20\u529b\u969c\u788d\u60a3\u8005<\/strong><\/p>\n

\u7b5b\u9009\u591a\u4e2a\u5019\u9009\u57fa\u56e0\u7684\u6709\u6548\u65b9\u6cd5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n

\u808c\u5f20\u529b\u969c\u788d\u662f\u4e00\u79cd\u5177\u6709\u9ad8\u5ea6\u4e34\u5e8a\u548c\u9057\u4f20\u5f02\u8d28\u6027\u7684\u8fd0\u52a8\u65b9\u5f0f\u3002\u5206\u5b50\u8bca\u65ad\u5bf9\u4e8e\u51c6\u786e\u8bca\u65ad\u808c\u5f20\u529b\u969c\u788d\u5f88\u91cd\u8981\u3002\u9776\u5411\u4e0b\u4e00\u4ee3\u6d4b\u5e8f\u5df2\u7ecf\u6210\u4e3a\u540c\u65f6\u7b5b\u9009\u591a\u4e2a\u5019\u9009\u57fa\u56e0\u7684\u6709\u6548\u65b9\u6cd5\u3002\u4f46\u662f\u8be5\u65b9\u6cd5\u5374\u5f88\u5c11\u88ab\u62a5\u9053\u7528\u4e8e\u808c\u5f20\u529b\u969c\u788d\u60a3\u8005\u3002<\/p>\n


<\/p>\n

\u57fa\u4e8e\u6b64\uff0cJun Ma \u7b49\u7814\u7a76\u8005\u5bf9 65 \u540d\u8bca\u65ad\u808c\u5f20\u529b\u969c\u788d\u7684\u4e2d\u56fd\u6c49\u65cf\u60a3\u8005\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u60a3\u8005\u5e73\u5747\u53d1\u75c5\u5e74\u9f84 22.7 \u5c81\u3002<\/p>\n


<\/p>\n

\u7814\u7a76\u8005\u9996\u5148\u5728\u7ebf\u5b5f\u5fb7\u5c14\u9057\u4f20\uff08Online Mendelian Inheritance in Man\uff0cOMIM\uff09\u6570\u636e\u5e93\u548c\u4eba\u7c7b\u57fa\u56e0\u7a81\u53d8\u6570\u636e\u5e93\uff08Human Gene Mutation Database\uff0cHGMD\uff09\u6570\u636e\u5e93\u4e2d\u68c0\u7d22\u4e86\u4e0e\u62a5\u9053\u4e0e\u808c\u5f20\u529b\u969c\u788d\u76f8\u5173\u7684\u6570\u636e\u5e93\uff0c\u5e76\u901a\u8fc7\u8bbe\u8ba1\u6355\u83b7 panel \u7528\u4e8e\u6355\u83b7\u6240\u6709\u5916\u663e\u5b50\u3001\u526a\u63a5\u4f4d\u70b9\u548c 148 \u4e2a\u57fa\u56e0\u7684\u7d27\u90bb\u5185\u542b\u5b50\u5e8f\u5217\u3002<\/p>\n


<\/p>\n

\u5728\u5bcc\u96c6\u9776\u57fa\u56e0\u540e\uff0c\u8fdb\u884c\u4e0b\u4e00\u4ee3\u6d4b\u5e8f\u548c\u751f\u7269\u4fe1\u606f\u5206\u6790\u3002\u4f7f\u7528 sanger \u6d4b\u5e8f\u6765\u8bc1\u5b9e\u8fd9\u4e9b\u53d1\u73b0\u3002<\/p>\n


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\u6839\u636e\u7f8e\u56fd\u533b\u5b66\u9057\u4f20\u5b66\u5b66\u4f1a\uff08American College of Medical Genetics and Genomics\uff0cACMG\uff09\u6807\u51c6\u548c\u6307\u5357\u5bf9\u5df2\u9274\u5b9a\u53d8\u4f53\u7684\u5f71\u54cd\u8fdb\u884c\u5206\u7c7b\u3002<\/p>\n


<\/p>\n

\u7ed3\u679c\u53d1\u73b0\uff0c\u6839\u636e ACMG \u6807\u51c6\u548c\u6307\u5357\uff0c\u5728 65 \u540d\u60a3\u8005\u4e2d\uff0c12 \u540d\uff0818.5%\uff09\u88ab\u9274\u5b9a\u4e3a TOR1A\uff0cPANK2 \u6216 IATP1A3 \u7684\u81f4\u75c5\u57fa\u56e0\u7a81\u53d8\uff0c\u53e6\u5916 4 \u540d\uff0846.2%\uff09\u88ab\u9274\u5b9a\u4e3a\u53ef\u80fd\u81f4\u75c5\u7684\u57fa\u56e0\u7a81\u53d8 PRRT2\uff0cGCH1 \u6216 THAP1\uff0c\u603b\u5171\u6709 24.6% \u7684\u60a3\u8005\u88ab\u53d1\u73b0\u6709\u808c\u5f20\u529b\u969c\u788d\u9057\u4f20\u56e0\u7d20\u3002\u6700\u5e38\u89c1\u7684\u68c0\u6d4b\u57fa\u56e0\u662f TOR1A\uff0c\u5df2\u77e5\u662f dYT1 \u7684\u81f4\u75c5\u56e0\u5b50\uff0812.3%\uff09\u3002<\/p>\n


<\/p>\n

\u603b\u4e4b\uff0c\u8be5\u7814\u7a76\u8868\u660e\uff0c\u9776\u5411\u4e0b\u4e00\u4ee3\u6d4b\u5e8f\u53ef\u4ee5\u6210\u4e3a\u808c\u5f20\u529b\u969c\u788d\u60a3\u8005\u7b5b\u9009\u591a\u4e2a\u5019\u9009\u57fa\u56e0\u7684\u6709\u6548\u65b9\u6cd5\u3002<\/strong><\/p>\n


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\u5149\u9057\u4f20\u5b66\u548c\u5316\u5b66\u9057\u4f20\u5b66\u7814\u7a76<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Alexandra \u5bf9\u4e86\u89e3\u8fd0\u52a8\u969c\u788d\u7684\u5de5\u5177-\u5149\u9057\u4f20\u5b66\u548c\u5316\u5b66\u9057\u4f20\u5b66\u8fdb\u884c\u4e86\u7efc\u8ff0\uff0c\u603b\u7ed3\u5982\u4e0b\uff1a<\/span>
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Ø  \u52a8\u7269\u6a21\u578b\u5e76\u4e0d\u603b\u80fd\u53cd\u6620\u4eba\u7c7b\u60a3\u8005\u7684\u60c5\u51b5\uff1a\u5c3d\u53ef\u80fd\u4f7f\u7528\u4eba\u7c7b\u6570\u636e\u8fdb\u884c\u6d4b\u8bd5\u81f3\u5173\u91cd\u8981\uff1b<\/span>
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Ø  \u91cd\u8981\u7684\u95ee\u9898\u5e76\u4e0d\u603b\u662f\u9700\u8981\u8fb9\u7f18\u6280\u672f\uff1a\u771f\u6b63\u7684\u65b9\u6cd5\u7ecf\u5e38\u4f1a\u5f97\u5230\u66f4\u597d\u7684\u9a8c\u8bc1\uff0c\u4e5f\u4f1a\u66f4\u52a0\u6709\u8bf4\u670d\u529b\uff0c\u4fbf\u4e8e\u89e3\u91ca\uff1b<\/p>\n


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Ø  \u5149\u9057\u4f20\u5b66\u548c\u5316\u5b66\u9057\u4f20\u5b66\u662f\u5f3a\u5927\u7684\u6280\u672f\uff0c\u5fc5\u987b\u4e86\u89e3\u5b83\u4eec\u662f\u5982\u4f55\u5de5\u4f5c\u7684\uff0c\u5e76\u9009\u62e9\u53ef\u4ee5\u53cd\u6620\u5178\u578b\u751f\u7406\u5b66\u7684\u5b9e\u9a8c\u53c2\u6570\uff1b<\/p>\n


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Ø  \u5149\u9057\u4f20\u5b66\u548c\u5316\u5b66\u9057\u4f20\u5b66\u53ef\u4ee5\u626d\u66f2\u6b63\u5e38\u7684\u795e\u7ecf\u6d3b\u52a8\u5e76\u4ea7\u751f\u4f2a\u5f71\uff0c\u5b83\u5bf9\u4e8e\u8865\u5145\u89c2\u5bdf\u548c\u64cd\u4f5c\uff08\u6fc0\u6d3b\/\u6291\u5236\uff09\u975e\u5e38\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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LRRK2 \u9176\u6291\u5236\u5242<\/strong>\u53ef\u4f5c\u4e3a PD \u6cbb\u7597\u7684\u9776\u70b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5bcc\u542b\u4eae\u6c28\u9178\u7684\u91cd\u590d\u6fc0\u9176 2\uff08Leucine-rich repeat kinase 2\uff0cLRRK2\uff09\u57fa\u56e0\u662f PD \u60a3\u8005\u548c\u4e9a\u6d32\u4eba\u4e2d\u6700\u5e38\u89c1\u7684\u57fa\u56e0\u7a81\u53d8\uff0c\u5b83\u5177\u6709\u4ee5\u4e0b\u7279\u70b9\uff1a<\/span>
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1. \u6709\u79cd\u65cf\u7279\u5f02\u6027\u98ce\u9669\u591a\u6001\u6027\uff1b<\/p>\n


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2. LRRK2 \u7a81\u53d8\u7684\u4e34\u5e8a\u8868\u578b\u7c7b\u4f3c\u4e8e\u7279\u53d1\u6027\u8fdf\u53d1\u6027 PD\uff0c\u4f46\u4e0e\u76ee\u524d\u5176\u4ed6\u57fa\u56e0\u9274\u5b9a\u65b9\u6cd5\u4e0d\u540c\uff1b<\/p>\n


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3. \u75c5\u7406\u7279\u5f81\u662f\u540c\u8d28\u5f02\u5f62\u7684\uff0c\u5305\u62ec\u7a81\u89e6\u6838\u86cb\u767d\u75c5\u548c Tau \u86cb\u767d\u75c5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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LRRK2 \u9176\u6291\u5236\u5242\u53ef\u80fd\u662f\u6cbb\u7597 PD \u7684\u4e00\u79cd\u65b0\u65b9\u6cd5\uff0c\u76ee\u524d LRRK2 \u9176\u6291\u5236\u5242 DNL-201 \u5df2\u7ecf\u5b8c\u6210\u4e86 1 \u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002LRRK2 \u9176\u6291\u5236\u5242-\u6d1b\u4f10\u4ed6\u6c40\u6cbb\u7597\u65e9\u671f PD \u60a3\u8005\u7684 2 \u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u6b63\u5728\u8fdb\u884c\u4e2d\u3002\u5c06\u6765\u50cf LRRK2 \u9176\u6291\u5236\u5242\u8fd9\u79cd\u4e2a\u4f53\u5316\u6cbb\u7597\u65b9\u6cd5\u4f1a\u662f PD \u6cbb\u7597\u7684\u65b0\u9009\u62e9\u3002<\/span>
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\u4e0d\u5b81\u817f\u7efc\u5408\u5f81\u7814\u7a76\u8fdb\u5c55<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0d\u5b81\u817f\u7efc\u5408\u5f81\uff08Restless legs syndrome\uff0cRLS\uff09\u662f PD \u60a3\u8005\u7684\u4e00\u79cd\u8fd0\u52a8\u75c7\u72b6\uff0c\u8be5\u75c7\u72b6\u5e38\u5728\u4f11\u606f\u65f6\u53d1\u4f5c\uff0c\u7ed9\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\u9020\u6210\u4e86\u4e25\u91cd\u5f71\u54cd\u3002Julian \u5bf9\u76ee\u524d\u4e0d\u5b81\u817f\u7efc\u5408\u5f81\u7684\u75c5\u7406\u751f\u7406\u53ca\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\u8fdb\u884c\u4e86\u6c47\u62a5\uff1a<\/p>\n


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1. \u78c1\u5171\u632f\u5bfc\u5411\u7684\u805a\u7126\u8d85\u58f0\uff08Magnetic Resonance-guided Focused Ultrasound\uff0cMRgFUS\uff09\uff1a<\/p>\n


<\/p>\n

\u77e5\u9053\u9776\u5411\u548c\u907f\u514d\u54ea\u4e9b\u795e\u7ecf\u5355\u5143\uff0c\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u5728\u6539\u8fdb\u624b\u672f\u4ee5\u83b7\u5f97\u957f\u671f\u6548\u76ca\u7684\u540c\u65f6\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u7387\u3002<\/p>\n


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2. \u529f\u80fd\u6027\u78c1\u5171\u632f\u6210\u50cf\uff08Functional magnetic resonance imaging\uff0cfMRI\uff09\uff1a<\/p>\n


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fMRI \u53ef\u7528\u4e8e\u7ed8\u5236\u6df1\u90e8\u8111\u523a\u6fc0\uff08Deep brain stimulation\uff0cDBS\uff09\u7684\u7535\u8def\u6548\u5e94\uff0c\u5e76\u53ef\u80fd\u9274\u5b9a\u4e00\u79cd\u80fd\u591f\u9884\u6d4b\u6cbb\u7597\u6210\u529f\u7684\u751f\u7269\u6807\u8bb0\u7269\u3002fMRI \u6709\u52a9\u4e8e\u7406\u89e3 DBS \u7684\u4f5c\u7528\u673a\u5236\uff0c\u4e5f\u53ef\u80fd\u6307\u5bfc\u6cbb\u7597\u7684\u8fdb\u884c\u3002<\/p>\n


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3. \u8d85\u9ad8\u9891\u7535\u523a\u6fc0\uff08Ultra high frequency stimulation\uff0cUHFS\uff09\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u6211\u4eec\u4e0d\u77e5\u9053 UHFS \u662f\u5426\u6709\u7528\uff0c\u4f46\u662f 10 kHz DBS \u4e3a\u53d1\u73b0 DBS \u53ef\u80fd\u7684\u4e00\u79cd\u65b0\u4f5c\u7528\u673a\u5236\u548c DBS \u7684\u65b0\u53c2\u6570\u63d0\u4f9b\u4e86\u673a\u4f1a\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n


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\u7f16\u8f91\uff1aAcheng<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u7b2c 22 \u5c4a\u56fd\u9645\u5e15\u91d1\u68ee\u53ca\u8fd0\u52a8\u969c\u788d\u5927\u4f1a(International Congress of Parkinson\u2019 […]<\/p>\n","protected":false},"author":1,"featured_media":63906,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/63905"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=63905"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/63905\/revisions"}],"predecessor-version":[{"id":63913,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/63905\/revisions\/63913"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/63906"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=63905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=63905"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=63905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}