{"id":6393,"date":"2018-06-08T01:00:00","date_gmt":"2018-07-27T09:14:18","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/mcao%e6%a8%a1%e5%9e%8b%e4%b8%96%e7%95%8c%e9%a6%96%e5%88%9b%e8%80%85%e5%9c%a8%e7%ba%bf%e5%8f%91%e8%a1%a8%e4%b8%81%e8%8b%af%e9%85%9estroke%e7%a0%94%e7%a9%b6%e9%a2%86%e5%9f%9f%e7%9a%84%e9%87%8d%e7%a3%85\/"},"modified":"2018-07-27T17:14:21","modified_gmt":"2018-07-27T09:14:21","slug":"mcao%e6%a8%a1%e5%9e%8b%e4%b8%96%e7%95%8c%e9%a6%96%e5%88%9b%e8%80%85%e5%9c%a8%e7%ba%bf%e5%8f%91%e8%a1%a8%e4%b8%81%e8%8b%af%e9%85%9estroke%e7%a0%94%e7%a9%b6%e9%a2%86%e5%9f%9f%e7%9a%84%e9%87%8d%e7%a3%85","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/6393\/","title":{"rendered":"MCAO\u6a21\u578b\u4e16\u754c\u9996\u521b\u8005\u5728\u7ebf\u53d1\u8868\u4e01\u82ef\u915eStroke\u7814\u7a76\u9886\u57df\u7684\u91cd\u78c5\u7ed3\u679c"},"content":{"rendered":"
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\u8fd1\u65e5\uff0c\u300aJournal of Cerebral Blood Flow & Metabolism\u300b\u671f\u520a\uff08IF\uff1a5.081\u5206\uff09\u5728\u7ebf\u53d1\u8868\u4e86\u4e00\u7bc7\u6765\u81ea\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66Med-X\u7814\u7a76\u9662\u6768\u56fd\u6e90\u6559\u6388\u56e2\u961f\u7684\u7814\u7a76\u6210\u679c\uff0c\u7814\u7a76\u8005\u53d1\u73b0\u4e01\u82ef\u915e\uff08NBP\uff09\u53ef\u4ee5\u901a\u8fc7\u589e\u52a0\u5c40\u90e8\u8840\u6d41\u3001\u51cf\u5c11\u8840\u6813\u5f62\u6210\u548c\u6062\u590d\u53d7\u635f\u90e8\u4f4d\u8840\u7ba1\u7ba1\u5f84\u51cf\u8f7b\u8111\u635f\u4f24[1]<\/sup>\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

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\"MCAO\u6a21\u578b\u4e16\u754c\u9996\u521b\u8005\u5728\u7ebf\u53d1\u8868\u4e01\u82ef\u915eStroke\u7814\u7a76\u9886\u57df\u7684\u91cd\u78c5\u7ed3\u679c\"<\/p>\n

Figure 1. The effect of NBP on the reduction of brain injury.<\/span><\/p>\n


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\"MCAO\u6a21\u578b\u4e16\u754c\u9996\u521b\u8005\u5728\u7ebf\u53d1\u8868\u4e01\u82ef\u915eStroke\u7814\u7a76\u9886\u57df\u7684\u91cd\u78c5\u7ed3\u679c\" Figure 2. The effect of NBP on mRNA expression of thrombosis and vascular contraction system.<\/span><\/p>\n


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\"MCAO\u6a21\u578b\u4e16\u754c\u9996\u521b\u8005\u5728\u7ebf\u53d1\u8868\u4e01\u82ef\u915eStroke\u7814\u7a76\u9886\u57df\u7684\u91cd\u78c5\u7ed3\u679c\"<\/p>\n

Figure 3. Continuous treatment with NBP for seven days attenuated the thrombosis in the ischemic artery.<\/span><\/p>\n


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Figure 4. Vasodilation effect of NBP on the MCA in the acute phase of tMCAO.<\/span><\/p>\n

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\u8be5\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4e01\u82ef\u915e\uff08NBP\uff09\u5bf9\u8111\u90e8\u8840\u6d41\u91cf\u7684\u8c03\u8282\u4f5c\u7528\uff0c\u53ef\u80fd\u662f\u901a\u8fc7\u5bf9\u7f3a\u8840\u533a\u57df\u7684\u8840\u7ba1\u8fdb\u884c\u529f\u80fd\u6539\u5584\u6765\u5b9e\u73b0\u8840\u6d41\u589e\u52a0\u3002\u800c\u4e01\u82ef\u915e\u5bf9\u7f3a\u8840\u533a\u57df\u8111\u8840\u7ba1\u529f\u80fd\u4f5c\u7528\u5206\u5b50\u8868\u8fbe\u6c34\u5e73\u7684\u6539\u53d8\uff0c\u5f88\u53ef\u80fd\u80fd\u591f\u6539\u5584\u8111\u8840\u7ba1\u7684\u529f\u80fd\uff0c\u4ece\u800c\u5bf9\u8111\u8840\u7ba1\u7684\u5f62\u6001\u548c\u529f\u80fd\u4ea7\u751f\u5f71\u54cd\u3002\u4e01\u82ef\u915e\u9664\u4e86\u80fd\u591f\u6062\u590d\u53d7\u635f\u90e8\u4f4d\u7684\u8840\u7ba1\u7ba1\u5f84\uff0c\u5bf9\u8840\u6813\u7684\u5f62\u6210\u4ea7\u751f\u6291\u5236\u4f5c\u7528\uff0c\u8fd8\u53ef\u80fd\u4f1a\u5bf9\u8840\u8111\u5c4f\u969c\u548c\u5185\u76ae\u7ec6\u80de\u529f\u80fd\u8d77\u5230\u8c03\u8282\u4f5c\u7528\uff0c\u8be5\u9879\u7814\u7a76\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u51af\u4ea6\u749e\u7814\u7a76\u5458\u4e01\u82ef\u915e\u53ef\u6291\u5236\u8840\u6813\u5f62\u6210\u7684\u7ed3\u8bba[2]<\/sup>\uff0c\u8fd8\u4e30\u5bcc\u4e86\u9ec4\u5982\u8bad[3]<\/sup>\u3001Hari Shanker Sharma[4]<\/sup>\u7b49\u56fd\u5185\u5916\u591a\u4f4d\u6559\u6388\u5728\u4e01\u82ef\u915e\u4fdd\u62a4\u8840\u8111\u5c4f\u969c\u53ca\u5185\u76ae\u7ec6\u80de\u529f\u80fd\u65b9\u9762\u7684\u7814\u7a76\u8bc1\u636e\u3002\u540e\u7eed\u6768\u56fd\u6e90\u6559\u6388\u56e2\u961f\u8ba1\u5212\u5728\u4e01\u82ef\u915e\u5bf9\u8840\u7ba1\u529f\u80fd\u8c03\u8282\u7684\u673a\u5236\u65b9\u9762\u8fdb\u884c\u6df1\u5165\u7814\u7a76\uff0c\u671f\u5f85\u4e0b\u4e00\u4e2a\u7814\u7a76\u6210\u679c\u7684\u53d1\u5e03\u3002<\/span><\/p>\n<\/section>\n<\/blockquote>\n<\/section>\n<\/section>\n


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\u4e0a\u6d77\u5149\u6e90 (Shanghai Synchrotron Radiation Facility\uff0cSSRF)\uff0c\u662f\u4e16\u754c\u4e0a\u7b2c\u56db\u4e2a\u62e5\u6709\u7b2c\u4e09\u4ee3\u540c\u6b65\u8f90\u5c04\u5149\u6e90\u7535\u5b50\u675f\u7684\u88c5\u7f6e\uff08\u5176\u4ed6\u4e09\u4e2a\u4e3a\u65e5\u672c\uff1aSPring-8\uff1b\u6fb3\u5927\u5229\u4e9a\uff1aAPS\uff1b\u6b27\u6d32\u5149\u6e90\uff08\u6cd5\u56fd\uff09\uff1aESRF\uff09\uff0c\u662f\u4e2d\u56fd\u91cd\u5927\u79d1\u5b66\u5de5\u7a0b\uff0c\u6295\u8d44\u903e12\u4ebf\u4eba\u6c11\u5e01\uff0c\u8fd9\u662f\u4e2d\u56fd\u81f32010\u5e741\u670820\u65e5\u524d\u89c4\u6a21\u6700\u5927\u7684\u79d1\u5b66\u88c5\u7f6e\u3002\u8fd9\u4e2a\u79d1\u5b66\u88c5\u7f6e\u5efa\u6210\u540e\uff0c\u5bf9\u63a8\u52a8\u4e2d\u56fd\u591a\u5b66\u79d1\u9886\u57df\u7684\u79d1\u6280\u521b\u65b0\u548c\u4ea7\u4e1a\u5347\u7ea7\u4ea7\u751f\u4e86\u91cd\u5927\u4f5c\u7528\u3002<\/p>\n

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\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n

[1] dl-3-N-butylphthalide attenuates ischemic reperfusion injury by improving the function of cerebral artery and circulation.<\/span><\/p>\n

[2] Peng Y, Zeng X, Feng Y, et al. Antiplatelet and antithrombotic activity of L-3-n-butylphthalide in rats.[J]. Journal of Cardiovascular Pharmacology, 2004, 43(6):876.<\/span><\/p>\n

[3] Li L, Zhang B, Tao Y, et al. DL-3-n-butylphthalide protects endothelial cells against oxidative\/nitrosative stress, mitochondrial damage and subsequent cell death after oxygen glucose deprivation in vitro[J]. Brain Research, 2009, 1290(1290):91-101.<\/span><\/p>\n

[4] Feng L, Sharma A, Niu F, et al. TiO2-Nanowired Delivery of DL-3-n-butylphthalide (DL-NBP) Attenuates Blood-Brain Barrier Disruption, Brain Edema Formation, and Neuronal Damages Following Concussive Head Injury.[J]. Molecular Neurobiology, 2017, 1625:1-9.<\/span><\/p>\n<\/section>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u795e\u7ecf\u65f6\u95f4 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u8fd1\u65e5\uff0c\u300aJournal of Cerebral Blood Flow & Metabolism\u300b\u671f\u520a\uff08 […]<\/p>\n","protected":false},"author":1,"featured_media":6394,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/6393"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=6393"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/6393\/revisions"}],"predecessor-version":[{"id":6401,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/6393\/revisions\/6401"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/6394"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=6393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=6393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=6393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}