{"id":64397,"date":"2018-12-05T01:00:00","date_gmt":"2018-12-07T03:38:28","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/a2ca9ce14b\/"},"modified":"2018-12-07T11:38:32","modified_gmt":"2018-12-07T03:38:32","slug":"a2ca9ce14b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/64397\/","title":{"rendered":"Semaglutide\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"
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\u8bfa\u548c\u8bfa\u5fb7\u4e8e\u5f53\u5730\u65f6\u95f42018\u5e7411\u670823\u65e5\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u65d7\u4e0b\u53e3\u670dGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242Semaglutide\u7684\u6700\u540e\u4e00\u9879\u5168\u7403\u6027\u2162a\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08PIONEER 6\uff09\u5230\u8fbe\u5176\u975e\u52a3\u6027\u7ec8\u70b9\u6307\u6807\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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 \u5168\u65876973\u5b57\uff0c\u7528\u65f614\u5206\u949f<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u4f5c\u8005\uff1a\u5411\u98de
<\/span><\/p>\n

\u603b\u90e8\u4f4d\u4e8e\u4e39\u9ea6\u54e5\u672c\u54c8\u6839\u7684\u5168\u7403\u7cd6\u5c3f\u75c5\u5de8\u5934\u8bfa\u548c\u8bfa\u5fb7\u516c\u53f8\u4e8e\u5f53\u5730\u65f6\u95f42018\u5e7411\u670823\u65e5\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u65d7\u4e0b\u53e3\u670dGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242Semaglutide\u7684\u6700\u540e\u4e00\u9879\u5168\u7403\u6027\u2162a\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08PIONEER 6\uff09\u5230\u8fbe\u5176\u975e\u52a3\u6027\u7ec8\u70b9\u6307\u6807\u3002\u8be5\u9879\u53cc\u76f2\u8bd5\u9a8c\u5171\u7eb3\u5165\u4e863183\u540d\u6613\u53d1\u751f\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\uff0c\u5e76\u8003\u5bdf\u4e86\u53d7\u8bd5\u8005\u5728\u6807\u51c6\u62a4\u7406\u7684\u57fa\u7840\u4e0a\u5206\u522b\u6dfb\u52a0\u53e3\u670dSemaglutide 14 mg\u6216\u5b89\u6170\u5242\u6cbb\u7597\u7684\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u3002\u5728\u4e2d\u4f4d16\u4e2a\u6708\u7684\u968f\u8bbf\u671f\u5185\uff0c\u5171\u53d1\u751f\u4e86137\u4f8b\u91cd\u5927\u4e0d\u826f\u5fc3\u8840\u7ba1\u4e8b\u4ef6\uff08MACE\uff09\u3002\u8be5\u9879\u8bd5\u9a8c\u4ee5\u9996\u6b21\u53d1\u751f\u7684\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u808c\u6897\u585e\u4e0e\u975e\u81f4\u6b7b\u6027\u5352\u4e2d\u6240\u6784\u6210\u4e86MACE\u590d\u5408\u7ed3\u5c40\u4f5c\u4e3a\u5176\u4e3b\u8981\u7684\u7ec8\u70b9\u6307\u6807\uff0c\u800c\u53e3\u670dSemaglutide\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u7684\u5371\u9669\u6bd4\u4e3a0.79\uff0c\u4ee3\u8868\u7740\u53e3\u670dsemaglutide\u7ec4\u7684MACE\u53d1\u751f\u7387\u6bd4\u5b89\u6170\u5242\u7ec4\u4f4e21%\uff0c\u4f46\u8fd9\u4e00\u5dee\u5f02\u672a\u8fbe\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u3002<\/span><\/p>\n

Semaglutide\u662f\u7531\u8bfa\u548c\u8bfa\u5fb7\u516c\u53f8\u5f00\u653e\u7684\u65b0\u578b\u957f\u6548GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u4e8e\u53bb\u5e74\u5e74\u5e95\u83b7\u5f97FDA\u6279\u51c6\uff0c\u4ee5\u6bcf\u5468\u76ae\u4e0b\u6ce8\u5c041\u6b21\u7684\u5242\u91cf\u7528\u4e8e2\u578b\u7cd6\u5c3f\u75c5\u7684\u6cbb\u7597\u3002FDA\u7684Drug Labelling\u4e2d\u6536\u5f55\u7684SUSTAIN \u7cfb\u5217\u8bd5\u9a8c\u8bc1\u5b9eSemaglutide\u7684\u964d\u7cd6\u4e0e\u51cf\u91cd\u6548\u679c\u4f18\u4e8e\u5b89\u6170\u5242\u3001\u897f\u683c\u5217\u6c40\u3001\u7f13\u91ca\u827e\u585e\u90a3\u80bd\u4e0e\u80f0\u5c9b\u7d20\u7b49\u5bf9\u7167\u836f\uff0c\u4ece\u800c\u66fe\u7ecf\u4e00\u5ea6\u88ab\u8a89\u4e3a\u53f2\u4e0a\u6700\u597d\u7684\u964d\u7cd6\u836f\u3002\u9664\u4e86\u76ae\u4e0b\u6ce8\u5c04\u5242\u578b\uff0c\u8bfa\u548c\u8bfa\u5fb7\u8fd8\u91c7\u7528N-(8-[2-\u7f9f\u57fa\u82ef\u7532\u9170\u57fa]\u6c28\u57fa)\u8f9b\u9178\u94a0\uff08SNAC\uff09\u4f5c\u4e3a\u5438\u6536\u4fc3\u8fdb\u5242\uff0c\u5f00\u53d1\u4e86Semaglutide\u53e3\u670d\u5242\u578b\uff0c\u5e76\u5728PIONEER\u7cfb\u5217\u8bd5\u9a8c\u4e2d\u8bc1\u5b9e\u4e86\u53e3\u670d\u5242\u578b\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u3002<\/span><\/p>\n

\u672c\u6587\u5bf92018\u5e746\u6708\u4ee5\u6765PUBMED\u6570\u636e\u5e93\u4e2d\u6536\u5f55\u7684Semaglutide\u4e34\u5e8a\u53ca\u5176\u76f8\u5173\u7814\u7a76\u8fdb\u884c\u4e86\u603b\u7ed3\u5206\u6790\u3002<\/span><\/p>\n

\n

1<\/strong><\/span>\u7279\u6b8a\u4eba\u7fa4\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u5b89\u5168\u6027\u4e0e\/\u6216\u8010\u53d7\u6027\u7814\u7a76<\/span><\/span><\/strong><\/p>\n

\uff081\uff09\u8003<\/span>\u5bdf\u80be\u529f\u80fd\u72b6\u6001\u5bf9\u53e3\u670dSemaglutide\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\u7684\u5f71\u54cd\u7684\u8bd5\u9a8c<\/span><\/strong>
<\/span><\/p>\n<\/section>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u8bfa\u548c\u8bfa\u5fb7\u7684\u7814\u7a76\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Clinical Pharmacokinetics \u6742\u5fd72018\u5e74\u7b2c57\u5377\u7b2c12\u671f\u3002<\/span><\/p>\n

\u3010\u8bd5\u9a8c\u8bbe\u8ba1\u3011\u5355\u7ec4\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u3010\u53d7\u8bd5\u8005\u57fa\u672c\u4fe1\u606f\u301124\u540d\u80be\u529f\u80fd\u6b63\u5e38\u8005\u300112\u540d\u8f7b\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u300112\u540d\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u300112\u540d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u8005\u4e0e11\u540d\u9700\u8981\u8840\u6db2\u900f\u6790\u7684\u665a\u671f\u80be\u75c5\uff08ESRD\uff09\u60a3\u8005\u3002<\/span><\/p>\n

\u3010\u5e72\u9884\u65b9\u6cd5\u3011\u7a7a\u8179\u72b6\u6001\u4e0b\u53e3\u670dSemaglutide\uff08\u4ee5SNAC\u4f5c\u4e3a\u5438\u6536\u4fc3\u8fdb\u5242\uff0c5 mg qd\u00d75\u5929\uff0c\u800c\u540e10mg qd\u00d75\u5929\uff09\uff0c\u800c\u540e\u7ee7\u7eed\u7a7a\u817930\u5206\u949f\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u53d7\u8bd5\u8005\u80be\u529f\u80fd\u72b6\u6001\u5bf9\u5176\u4f53\u5185\u7684Semaglutide\u66b4\u9732\u6c34\u5e73\u4e0e\u534a\u8870\u671f\uff08\u51e0\u4f55\u5747\u6570\u8303\u56f4\u5728\u5728152~165h\u4e4b\u95f4\uff09\u65e0\u663e\u8457\u5f71\u54cd\u3002\u9664\u4e861\u540dESRD\u60a3\u8005\u4ee5\u5916\u7684\u5176\u4ed6\u53d7\u8bd5\u8005\u5c3f\u6db2\u5185\u5747\u672a\u68c0\u51faSemaglutide\u3002\u8840\u6db2\u900f\u6790\u4e5f\u4e0d\u5f71\u54cdSemaglutide\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u3002\u8be5\u9879\u8bd5\u9a8c\u4e2d\u7684\u4e0d\u826f\u53cd\u5e94\u4e0e\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u76f8\u4f3c\uff0c\u800c\u4e14\u672a\u89c1\u65b0\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u8bba\u3011\u80be\u529f\u80fd\u635f\u4f24\u8005\u53e3\u670dSemaglutide\u65e0\u987b\u8c03\u6574\u5242\u91cf\u3002<\/span><\/p>\n

\uff082\uff09\u8003\u5bdf\u809d\u529f\u80fd\u72b6\u6001\u5bf9\u53e3\u670dSemaglutide\u4f53\u5185\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\u7684\u5f71\u54cd\u7684\u7814\u7a76(NCT02016911)<\/span><\/strong><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u8bfa\u548c\u8bfa\u5fb7\uff1b\u65af\u6d1b\u4f10\u514bD\u00e9rer’s\u533b\u9662\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Journal of Clinical Pharmacology. 2018, 58 (10): 1314~1323<\/span><\/p>\n

\u3010\u8bd5\u9a8c\u8bbe\u8ba1\u3011\u5355\u7ec4\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u3010\u53d7\u8bd5\u8005\u57fa\u672c\u4fe1\u606f\u301124\u540d\u809d\u529f\u80fd\u6b63\u5e38\u8005\u300112\u540d\u8f7b\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u8005\u300112\u540d\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u4e0e8\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u8005\u3002<\/span><\/p>\n

\u3010\u5e72\u9884\u65b9\u6cd5\u3011\u7a7a\u8179\u72b6\u6001\u53e3\u670dSemaglutide\u5236\u5242\uff08\u51485 mg qd\u00d75\u5929\uff0c\u518d10 mg\u00d75\u5929\uff09\uff0c\u6240\u8ff0Semaglutide\u5236\u5242\u4e2d\u542b\u6709SNAC\u4f5c\u4e3a\u5438\u6536\u4fc3\u8fdb\u5242\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u5404\u809d\u529f\u80fd\u72b6\u6001\u7ec4\u7b2c10\u6b21\u7ed9\u836f\u540e0~24h\u7684SemaglutideAUC\u4e0e\u7b2c10\u6b21\u7ed9\u836f\u540e\u7684Cmax\u5747\u65e0\u663e\u8457\u7684\u7ec4\u95f4\u5dee\u5f02\uff0c\u6b64\u5916\u809d\u529f\u80fd\u72b6\u6001\u5bf9Semaglutide\u7684Tmax\uff081.0~1.5\u5c0f\u65f6\uff09\u6216\u534a\u8870\u671f\uff08\u51e0\u4f55\u5747\u6570\u8303\u56f4142~156\u5c0f\u65f6\uff09\u3002\u8be5\u9879\u8bd5\u9a8c\u4e2d\u672a\u89c1\u65b0\u7684\u5b89\u5168\u6027\u95ee\u9898\uff0c\u6240\u89c2\u5bdf\u5230\u7684\u4e0d\u826f\u53cd\u5e94\u4e0e\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u76f8\u4f3c\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u8bba\u3011\u809d\u529f\u80fd\u635f\u4f24\u8005\u53e3\u670dSemaglutide\u65e0\u987b\u8c03\u6574\u5242\u91cf\u3002<\/span><\/p>\n

\uff083\uff09\u8003\u5bdf\u5965\u7f8e\u62c9\u5511\u5bf9\u53e3\u670dSemaglutide\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\u7684\u8bd5\u9a8c<\/span><\/strong><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u8bfa\u548c\u8bfa\u5fb7\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Expert Opinion on Drug Metabolism and Toxicology. 2018, 14(8): 869~877\u3002<\/span><\/p>\n

\u3010\u8bd5\u9a8c\u8bbe\u8ba1\u3011\u5355\u4e2d\u5fc3\u3001\u968f\u673a\u5316\u3001\u5f00\u653e\u6807\u7b7e\u3001\u5e73\u884c\u7ec4\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u3010\u53d7\u8bd5\u8005\u57fa\u672c\u4fe1\u606f\u301154\u540d\u5065\u5eb7\u53d7\u8bd5\u8005\u3002<\/span><\/p>\n

\u3010\u5206\u7ec4\u4e0e\u5e72\u9884\u65b9\u6cd5\u3011\u53d7\u8bd5\u8005\u968f\u673a\u5206\u4e3a\u4e24\u7ec4\uff0c1\u7ec4\u5355\u72ec\u53e3\u670dSemaglutide\u56fa\u4f53\u5236\u5242\uff1b\u53e6\u4e00\u7ec4\u540c\u65f6\u53e3\u670dSemaglutide\u56fa\u4f53\u5236\u5242\u4e0e\u5965\u7f8e\u62c9\u5511\uff0840 mg qd\uff09\u3002\u6240\u8ff0Semaglutide\u56fa\u4f53\u5236\u5242\u4e2dSNAC\u4f5c\u4e3a\u5438\u6536\u4fc3\u8fdb\u5242\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011Semaglutide\u4e0e\u5965\u7f8e\u62c9\u5511\u540c\u65f6\u53e3\u670d\u4f1a\u4f7f\u524d\u8005\u7684\u4f53\u5185\u66b4\u9732\u6c34\u5e73\u51fa\u73b0\u4e0a\u5347\uff0c\u7136\u5176\u4e0a\u5347\u5e45\u5ea6\u65e0\u7edf\u8ba1\u5b66\u663e\u8457\u6027\uff0c\u800c\u4e14\u8054\u5408\u7528\u836f\u8005\u7684\u80c3\u5185pH\u503c\u9ad8\u4e8e\u5355\u72ec\u7528\u836f\u8005\u3002\u4e0d\u826f\u53cd\u5e94\u5747\u5448\u8f7b\u5ea6\u6216\u4e2d\u5ea6\uff0c\u800c\u4e14\u4ee5\u6d88\u5316\u9053\u75c7\u72b6\u6700\u4e3a\u5e38\u89c1\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u8bba\u3011\u53e3\u670dSemaglutide\u4e0e\u5965\u7f8e\u62c9\u5511\u8054\u5408\u7528\u836f\u65e0\u987b\u5bf9\u524d\u8005\u7684\u5242\u91cf\u8fdb\u884c\u8c03\u6574\u3002<\/span><\/p>\n

\n

2<\/strong><\/span>\u5bf9\u7279\u6b8a\u6709\u6548\u6027\u53c2\u6570\u7684\u5f71\u54cd<\/span><\/span><\/strong><\/p>\n

\uff081\uff09\u8bc4\u4ef7Semaglutide\u5bf92\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5904\u4e8e\u4f4e\u8840\u7cd6\u72b6\u6001\u65f6\u80f0\u9ad8\u8840\u7cd6\u7d20\u53ca\u5176\u4ed6\u53cd\u8c03\u8282\u6fc0\u7d20\u7684\u5f71\u54cd\u7684\u7814\u7a76<\/span><\/strong>
<\/span><\/p>\n<\/section>\n

\u3010\u7814\u7a76\u8005\u3011\u5965\u5730\u5229\u683c\u62c9\u8328\u533b\u79d1\u5927\u5b66\u4e0e\u8bfa\u548c\u8bfa\u5fb7\u7684\u7814\u7a76\u4eba\u5458\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Diabetes, Obesity and Metabolism \u6742\u5fd72018\u5e74\u7b2c20\u5377\u7b2c11\u671f\u3002<\/span><\/p>\n

\u3010\u8bd5\u9a8c\u8bbe\u8ba1\u3011\u968f\u673a\u5316\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u4ea4\u53c9\u3001\u5355\u4e2d\u5fc3\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u3010\u53d7\u8bd5\u8005\u57fa\u672c\u4fe1\u606f\u301138\u540d\u4ec5\u91c7\u7528\u4e8c\u7532\u53cc\u80cd\u6cbb\u7597\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3002<\/span><\/p>\n

\u3010\u5e72\u9884\u65b9\u6cd5\u3011\u968f\u673a\u5206\u7ec4\u540e\u5206\u522b\u91c7\u7528Semaglutideqw \u76ae\u4e0b\u6ce8\u5c04\u6216\u5b89\u6170\u5242\u76ae\u4e0b\u6ce8\u5c0412\u5468\uff0c\u800c\u540e\u4ea4\u53c9\u7528\u836f\uff0c\u7ee7\u7eed\u6cbb\u759712\u5468\u3002\u6bcf\u4e2a\u6cbb\u7597\u671f\u7ed3\u675f\u540e\u5747\u8fdb\u884c\u4f4e\u8840\u7cd6\u94b3\u5939\u672f\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u91c7\u7528\u4f4e\u8840\u7cd6\u94b3\u5939\u4f7f\u53d7\u8bd5\u8005\u8840\u7cd6\u4ece5.5 mmol\/L\u964d\u4f4e\u81f32.5 mmol\/L\u7684\u8fc7\u7a0b\u4e2d\uff0cSemaglutide\u4e0e\u5b89\u6170\u5242\u7ec4\u7ec4\u80f0\u9ad8\u8840\u7cd6\u7d20\u7684\u53d8\u5316\u60c5\u51b5\u5f7c\u6b64\u76f8\u4f3c\uff0888.3 vs 83.1 pg\/mL\uff09\uff0c\u800c\u4e24\u7ec4\u5176\u4ed6\u53cd\u8c03\u8282\u6fc0\u7d20\u6d53\u5ea6\u5747\u6709\u6240\u4e0a\u5347\uff0c\u5176\u4e2d\uff0cSemaglutide\u7ec4\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u4e0e\u76ae\u753e\u9187\u7684\u4e0a\u5347\u503c\u9ad8\u4e8e\u5b89\u6170\u5242\u5bf9\u7167\u3002\u4e24\u7ec4\u5b9e\u73b0\u6052\u5b9a\u94b3\u5939\u6c34\u5e73\u6240\u9700\u7684\u8461\u8404\u7cd6\u704c\u6ce8\u901f\u7387\u5f7c\u6b64\u76f8\u4f3c\uff0c\u63d0\u793a\u53cd\u8c03\u8282\u5e94\u7b54\u6c34\u5e73\u6574\u4f53\u76f8\u4f3c\u3002\u5f53\u8840\u7cd6\u964d\u81f32.5 mmol\/L\u65f6\uff0cSemaglutide\u7ec4\u7684\u5e73\u5747\u4f4e\u8840\u7cd6\u75c7\u72b6\u8bc4\u5206\u4e0e\u8ba4\u4e3a\u53d1\u751f\u4f4e\u8840\u7cd6\u53cd\u5e94\u7684\u53d7\u4f53\u6240\u5360\u6bd4\u4f8b\u5747\u4f4e\u4e8e\u5b89\u6170\u5242\u5bf9\u7167\uff0c\u4f46\u4e24\u7ec4\u7684\u8ba4\u77e5\u529f\u80fd\u6d4b\u8bd5\u7ed3\u679c\u5f7c\u6b64\u76f8\u4f3c\u3002Semaglutide\u672a\u89c1\u65b0\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u8bba\u3011Semaglutide\u6cbb\u7597\u4e0d\u4f1a\u635f\u5bb32\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5728\u8bd5\u9a8c\u578b\u4f4e\u8840\u7cd6\u8fc7\u7a0b\u4e2d\u7684\u53cd\u8c03\u8282\u5e94\u7b54\u6c34\u5e73\u3002<\/span><\/p>\n

\n

3<\/strong><\/span>\u4e0e\u5176\u4ed6\u964d\u7cd6\u836f\u6bd4\u8f83\u7684\u7814\u7a76<\/span><\/span><\/strong><\/p>\n

\uff081\uff09\u5728\u91c7\u7528\u81b3\u98df\u5e72\u9884\u4e0e\u589e\u52a0\u8fd0\u52a8\uff08\u00b1\u4e8c\u7532\u53cc\u80cd\uff09\u6cbb\u7597\u6548\u679c\u6b20\u4f73\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\u6bd4\u8f83Semaglutideqd\u4e0e\u5229\u62c9\u9c81\u80bd\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u7684\u7814\u7a76\uff08NCT02461589\uff09<\/span><\/strong>
<\/span><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u5fb7\u514b\u8428\u65af\u5927\u5b66\u897f\u5357\u533b\u5b66\u4e2d\u5fc3\uff1b\u5185\u5e03\u62c9\u65af\u52a0\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\u7b49\uff1b\u8bfa\u548c\u8bfa\u5fb7\u53c2\u4e0e\u3002<\/span><\/p>\n<\/section>\n

\u3010\u51fa\u5904\u3011Diabetes Care. 2018 Sep;41(9):1926-1937.<\/span><\/p>\n

\u3010\u8bd5\u9a8c\u8bbe\u8ba1\u3011\u4e3a\u671f26\u5468\u7684\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u968f\u673a\u5316\u3001\u8de8\u56fd\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u3010\u53d7\u8bd5\u8005\u57fa\u672c\u4fe1\u606f\u3011\u5728\u81b3\u98df\u5e72\u9884\u4e0e\u589e\u52a0\u8fd0\u52a8\u7684\u57fa\u7840\u4e0a\u6dfb\u52a0\u6216\u4e0d\u6dfb\u52a0\u4e8c\u7532\u53cc\u80cd\u6cbb\u7597\u4f46\u6548\u679c\u6b20\u4f73\uff08HbA1c\u57287.0~10.0%\u4e4b\u95f4\uff09\u3002\u5171\u5165\u7ec4705\u4eba\u3002<\/span><\/p>\n

\u3010\u5206\u7ec4\u4e0e\u5e72\u9884\u65b9\u6cd5\u3011\u53d7\u8bd5\u8005\u4ee52:2:1\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u5165Semaglutide qd\uff080.05 mg\u30010.1 mg\u30010.2 mg\u4e0e0.3mg\uff09\u7ec4\u3001\u5229\u62c9\u9c81\u80bd qd\uff080.3 mg\u30010.6 mg\u30011.2 mg\u4e0e1.8 mg\uff09\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u6cbb\u759726\u5468\uff0cSemaglutide\u7ec4\u7684HbA1c\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u7684\u4e0b\u964d\uff0c\u5176\u4e0b\u964d\u503c\u4f9d\u6b21\u4e3a-1.1%\uff080.05 mg\uff09~-1.9%\uff080.3 mg\uff09\u4e4b\u95f4\uff0c\u5747\u5747\u663e\u8457\u9ad8\u4e8e\u4f53\u79ef\u5339\u914d\u7684\u5229\u62c9\u9c81\u80bd\u7ec4[-0.5%\uff080.3 mg\uff09~-1.3%\uff081.8 mg\uff09\uff0cP<0.001]\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u6c47\u603b\u540e\u4e0b\u964d\u503c\u4e3a-0.02%\uff08\u4e0eSemaglutide\u76f8\u6bd4P<0.0001\uff09\u3002Semaglutide\u7ec4\u4e0e\u5229\u62c9\u9c81\u80bd\u7ec4\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u6d88\u5316\u9053\u4e0d\u826f\u53cd\u5e94\uff0c\u5176\u53d1\u751f\u7387\u5206\u522b\u662f32.8~54.0%\u4e0e21.9~41.5%\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u8bba\u3011Semaglutideqd\uff08\u6700\u9ad8\u5242\u91cf0.3 mg qd\uff09\u7684\u964dHbA1c\u6548\u679c\u663e\u8457\u4f18\u4e8e\u5229\u62c9\u9c81\u80bdqd\uff0c\u4f46\u5176\u6d88\u5316\u9053\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u4e5f\u9ad8\u4e8e\u540e\u8005\u3002<\/span><\/p>\n

\uff082\uff09\u6bd4\u8f83Semaglutide\u4e0e\u5229\u62c9\u9c81\u80bd\u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u7684\u7814\u7a76NCT02453711<\/span><\/strong><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u7f8e\u56fd\u5357\u5361\u7f57\u6765\u90a3\u533b\u79d1\u5927\u5b66\uff1b\u5fb7\u56fd\u5361\u9c81\u53e4\u65af\u5854\u592b\u5361\u9c81\u65af\u5927\u5b66\u533b\u9662\u7b49\uff1b\u8bfa\u548c\u8bfa\u5fb7\u53c2\u4e0e\u5e76\u8d44\u52a9\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Lancet. 2018, 392(10148): 637~648<\/span><\/p>\n

\u3010\u8bd5\u9a8c\u8bbe\u8ba1\u3011\u8de8\u56fd\uff08\u7f8e\u56fd\u3001\u5fb7\u56fd\u3001\u82f1\u56fd\u3001\u4ee5\u8272\u5217\u3001\u52a0\u62ff\u5927\u7b49\uff09\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u5316\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684\u5e73\u884c\u7ec4\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u3010\u53d7\u8bd5\u8005\u57fa\u672c\u4fe1\u606f\u3011\u5e74\u9f84\u226518\u5c81\uff0c\u672a\u5408\u5e76\u7cd6\u5c3f\u75c5\u7684\u80a5\u80d6\u75c7\u60a3\u8005\uff08BMI\u226530kg\/m2\uff09\u3002\u5171\u5904\u7ec4957\u4eba\u3002<\/span><\/p>\n

\u3010\u5206\u7ec4\u4e0e\u5e72\u9884\u65b9\u6cd5\u3011\u53d7\u8bd5\u8005\u4ee51:1:1:1:1:1:1\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u5165Semaglutide0.05 mg qd\u30010.1 mg qd\u30010.2 mg qd\u30010.3 mg qd\u4e0e0.4 mg qd\u7ec4\u3001\u5229\u62c9\u9c81\u80bd3.0 mg qd\u7ec4\u6216\u5339\u914d\u7684\u5b89\u6170\u5242\u7ec4\uff0c\u6240\u6709\u836f\u7269\u5747\u6bcf\u5929\u76ae\u4e0b\u6ce8\u5c041\u6b21\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u4e3b\u8981\u7684\u6709\u6548\u6027\u7ed3\u679c\u5982\u4e0b\u8868\u6240\u793a\u3002<\/span><\/p>\n

\"Semaglutide\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

<\/span>\u6b64\u5916\uff0cSemaglutide0.1~0.4mg\u7ec4\u4f53\u91cd\u4e0b\u964d\u226510%\u7684\u53d7\u8bd5\u8005\u6240\u5360\u6bd4\u4f8b\uff0837~65%\uff09\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff0810%\uff09\uff08P<0.0001\uff09\u3002<\/span><\/p>\n

\u5c31\u5b89\u5168\u6027\u7ed3\u679c\u800c\u8a00\uff0cSemaglutide\u5404\u5242\u91cf\u7ec4\u5747\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u7279\u5f81\uff0c\u672a\u89c1\u65b0\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u4ee5\u6076\u5fc3\u4e3a\u4e3b\u7684GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u6240\u5171\u6709\u7684\u6d88\u5316\u9053\u75c7\u72b6\uff0c\u4e14\u5177\u6709\u5242\u91cf\u4f9d\u8d56\u6027\u3002<\/span><\/p>\n

\n

4<\/strong><\/span>\u836f\u7269\u7ecf\u6d4e\u5b66\u7814\u7a76<\/span><\/span><\/strong><\/p>\n

\uff081\uff09\u6bd4\u8f83Semaglutideqw\u4e0e\u5ea6\u62c9\u9c81\u80bdqw\u5728\u82f1\u56fd\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u7684\u957f\u671f\u6210\u672c-\u6548\u76ca\u7279\u5f81\u7684\u7814\u7a76<\/span><\/strong>
<\/span><\/p>\n<\/section>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u82f1\u56fdLister\u533b\u9662\uff1b\u8bfa\u548c\u8bfa\u5fb7\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Diabetes, Obesity and Metabolism\uff0c2018\u5e7410\u670825\u65e5\u63d0\u524d\u53d1\u8868\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u4e0e\u5ea6\u62c9\u9c81\u80bd1.5 mg qw\u76f8\u6bd4\uff0cSemaglutide0.5 mg qw\u4e0e1 mg qw\u80fd\u4f7f\u82f1\u56fd2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u9884\u671f\u5bff\u547d\u5206\u522b\u6539\u55840.04\u4e0e0.10\u8d28\u91cf\u8c03\u6574\u7684\u5bff\u547d\u5e74\u3002\u7531\u4e8eSemaglutide\u7684\u964d\u7cd6\u6548\u679c\u4f18\u4e8e\u5ea6\u62c9\u9c81\u80bd\uff0c\u56e0\u6b64\u5728\u964d\u4f4e\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\u7684\u57fa\u7840\u4e0a\u83b7\u5f97\u4e34\u5e8a\u6548\u76ca\u65f6\u7684\u6210\u672c\u76f8\u5bf9\u8f83\u4f4e\uff0c\u5176\u4e2d\uff0c0.5 mg qw\u5242\u91cf\u4e0e1.0 mg qw\u5242\u91cf\u80fd\u4f7f\u60a3\u8005\u7684\u5bff\u547d\u6210\u672c\u5206\u522b\u964d\u4f4e35\u82f1\u9551\u4e0e106\u82f1\u9551\uff0c\u56e0\u6b64\u8ba4\u4e3a\uff0cSemaglutide0.5 mg qw\u4e0e1.0 mg qw\u7684\u6210\u672c\u6548\u76ca\u7279\u5f81\u4f18\u4e8e\u5ea6\u62c9\u9c81\u80bd1.5mg qw\u3002<\/span><\/p>\n

\uff082\uff09\u6bd4\u8f83Semaglutideqw\u4e0e\u5ea6\u62c9\u9c81\u80bd\u5728\u7f8e\u56fd\u5b9e\u73b0HbA1c\u4e0e\u4f53\u91cd\u63a7\u5236\u6548\u679c\u6240\u9700\u6210\u672c\u7684\u7814\u7a76<\/span><\/strong><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u8bfa\u548c\u8bfa\u5fb7\uff1b\u745e\u58eb\u5965\u897f\u65af\u5065\u5eb7\u7ecf\u6d4e\u4e0e\u901a\u8baf\u6709\u9650\u516c\u53f8\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Diabetes Therapy. 2018, 9(3): 951~961\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011Semaglutideqw\u6cbb\u7597\u540e\u5b9e\u73b0HbA1c\u63a7\u5236\u76ee\u6807\u7684\u60a3\u8005\u663e\u8457\u591a\u4e8e\u5ea6\u62c9\u9c81\u80bd\uff0c\u800cSemaglutideqw\u6240\u6709\u6a21\u62df\u7ec8\u70b9\u6307\u6807\u7684\u63a7\u5236\u6210\u672c\u5747\u4f4e\u4e8e\u5ea6\u62c9\u9c81\u80bd\uff0c\u5176\u4e2dSemaglutide1.0 mg qw\u4e0e\u5ea6\u62c9\u9c81\u80bd1.5 mg qw\u7528\u836f\u540e\u6bcf\u60a3\u8005\u5b9e\u73b0\u4e09\u79cd\u590d\u5408\u7ec8\u70b9\u6307\u6807\u7684\u6210\u672c\u5206\u522b\u4e3a11,916\u7f8e\u5143\u4e0e15,204\u7f8e\u5143\uff0c\u5373\u540e\u8005\u7684\u6210\u672c\u6bd4\u524d\u8005\u9ad828%\u3002\u800c\u4e3a\u4e86\u5b9e\u73b0\u76f8\u540c\u7684\u6307\u6807\uff0c\u5ea6\u62c9\u9c81\u80bd0.75 mg qw\u7684\u6210\u672c\u6bd4Semaglutide0.5 mg \u9ad868%\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u8bba\u3011\u5728\u7f8e\u56fd\uff0cSemaglutideqw\u7684\u6210\u672c-\u6548\u76ca\u7279\u5f81\u4f18\u4e8e\u5ea6\u62c9\u9c81\u80bdqw\u3002<\/span><\/p>\n

5<\/strong><\/span>\u6570\u636e\u518d\u8bc4\u4ef7\u5206\u6790<\/span><\/span><\/strong><\/p>\n

5.1 Meta\u5206\u6790<\/span><\/strong>
<\/span><\/p>\n

\uff081\uff09\u8bc4\u4ef7Semaglutide\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u6574\u4f53\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u7684\u7cfb\u7edf\u6027\u6587\u732e\u8bc4\u4ef7\u4e0eMeta\u5206\u6790<\/span><\/strong><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u6211\u56fd\u6cb3\u5317\u533b\u79d1\u5927\u5b66\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Endocrine. 2018, 62(3):535-545<\/span><\/p>\n

\u3010\u8bd5\u9a8c\u4e0e\/\u6216\u53d7\u8bd5\u8005\u57fa\u672c\u4fe1\u606f\u3011\u7eb3\u5165\u4e8611\u9879Semaglutide\u4e34\u5e8a\u8bd5\u9a8c\uff08N=9519\uff09\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011<\/span><\/p>\n

\u4e0e\u5b89\u6170\u5242\u53ca\u5176\u4ed6\u964d\u7cd6\u836f\u76f8\u6bd4\uff0cSemaglutide\u80fd\u8fdb\u4e00\u6b65\u6539\u5584\u53d7\u8bd5\u8005\u7684HbA1c\u3001\u81ea\u6d4b\u8840\u7cd6\uff08SMPG\uff09\u3001\u7a7a\u8179\u8840\u7cd6\uff08FPG\uff09\u4e0e\u4f53\u91cd\u7b49\u6709\u6548\u6027\u53c2\u6570\uff0c\u5176\u5e73\u5747\u5dee\u503c\uff08Semaglutide-\u5b89\u6170\u5242\u6216\u5176\u4ed6\u964d\u7cd6\u836f\uff09\u5982\u4e0b\u8868\u6240\u793a\u3002<\/span><\/p>\n

\"Semaglutide\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

<\/span>\u6b64\u5916\uff0cSemaglutide\u7ec4\u5b9e\u73b0HbA1c<7.0%\u7684\u8840\u7cd6\u63a7\u5236\u76ee\u6807\u7684\u53d7\u8bd5\u8005\u6240\u5360\u6bd4\u4f8b\u4e5f\u663e\u8457\u9ad8\u4e8e\u5b89\u6170\u5242\u6216\u5176\u4ed6\u964d\u7cd6\u836f\uff08\u98ce\u9669\u6bd4RR=2.26\uff0c95% CI\uff1a1.89~2.70\uff0cP<0.00001\uff09\u3002\u5c31\u5b89\u5168\u6027\u7ed3\u679c\u800c\u8a00\uff0cSemaglutide\u7ec4\u4e0d\u826f\u53cd\u5e94\u4e8b\u4ef6\u3001\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u4e8b\u4ef6\u4e0e\u4f4e\u8840\u7cd6\u4e8b\u4ef6\u53d1\u751f\u7387\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\u7684\u98ce\u9669\u6bd4\uff08RR\uff09\u5982\u4e0b\u8868\u6240\u793a\u3002<\/span><\/p>\n

\"Semaglutide\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

<\/span>\u3010\u4e3b\u8981\u7ed3\u8bba\u3011Semaglutide\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u65f6\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u7279\u5f81\uff0c\u540c\u65f6\u5408\u5e76\u80a5\u80d6\u75c7\u6216\u5bf9\u5176\u4ed6\u964d\u7cd6\u836f\u4f9d\u4ece\u6027\u4e0d\u4f73\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u53ef\u4ee5\u4f18\u5148\u8003\u8651Semaglutide.<\/span><\/p>\n

\uff082\uff09\u6bd4\u8f83Semaglutide qw\u4e0e\u5176\u4ed6\u80a0\u4fc3\u80f0\u7d20\u76f8\u5173\u6027\u964d\u7cd6\u836f\u57282\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u7684\u7cfb\u7edf\u6027\u8bc4\u4ef7\u4e0emeta\u5206\u6790<\/span><\/strong><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u4e1c\u5361\u7f57\u6765\u90a3\u5dde\u5927\u5b66\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Diabetes and Metabolism. 2018 Sep 20. pii: S1262-3636(18)30173-3\u3002<\/span><\/p>\n

\u3010\u7814\u7a76\u4e0e\/\u6216\u53d7\u8bd5\u8005\u7279\u5f81\u3011\u5171\u7eb3\u51655\u9879\u5bf9Semaglutide\u4e0e\u5176\u4ed6\u80a0\u4fc3\u80f0\u7d20\u76f8\u5173\u6027\u964d\u7cd6\u836f\uff08\u5305\u62ec\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u4e0eDPP-4\u6291\u5236\u5242\uff09\u8fdb\u884c\u6bd4\u8f83\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011<\/span><\/p>\n

Semaglutide\u964d\u4f4eHbA1c\u4e0e\u4f53\u91cd\u7684\u6548\u679c\u5747\u663e\u8457\u4f18\u4e8e\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u4e0eDPP-4\u6291\u5236\u5242\uff0c\u5177\u4f53\u7ed3\u679c\u5982\u4e0b\u8868\u6240\u793a\u3002<\/span><\/p>\n

\"Semaglutide\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

<\/span>Semaglutide\u7ec4\u5b9e\u73b0\u4e34\u5e8a\u663e\u8457\u6027\u8840\u7cd6\u63a7\u5236\u6548\u679c\u4e0e\u51cf\u91cd\u6548\u679c\u7684\u53d7\u8bd5\u8005\u6240\u5360\u6bd4\u4f8b\u5747\u663e\u8457\u9ad8\u4e8e\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u4e0eDPP-4\u6291\u5236\u5242\u3002\u7136\u800cSemaglutide\u7ec4\u5185\u6d88\u5316\u9053\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u7387\u5374\u9ad8\u4e8e\u5176\u4ed6\u4e24\u7ec4\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u8bba\u3011\u867d\u7136\u4e34\u5e8a\u8bd5\u9a8c\u4e2dSemaglutideqw\u4e0e\u5176\u4ed6\u80a0\u4fc3\u80f0\u7d20\u7c7b\u964d\u7cd6\u836f\u5747\u80fd\u663e\u8457\u964d\u4f4e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684HbA1c\uff0c\u7136\u800cSemaglutide\u7684\u964dHbA1c\u4e0e\u51cf\u91cd\u6548\u679c\u5747\u663e\u8457\u4f18\u4e8e\u5176\u4ed6\u80a0\u4fc3\u80f0\u7d20\u7c7b\u964d\u7cd6\u836f\u3002\u4e0e\u6b64\u540c\u65f6\uff0cSemaglutide\u7684\u6d88\u5316\u9053\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u4e5f\u6709\u6240\u5347\u9ad8\u3002<\/span><\/p>\n

\uff083\uff09\u6bd4\u8f83Semaglutideqw\u4e0eSGLT-2\u6291\u5236\u5242\u5728\u91c7\u7528\u4e8c\u7532\u53cc\u80cd\u5355\u836f\u6cbb\u7597\u8840\u7cd6\u63a7\u5236\u6548\u679c\u6b20\u4f73\u8005\u4e2d\u7684\u6709\u6548\u6027\u7684\u7cfb\u7edf\u6027\u8bc4\u4ef7\u4e0eMeta\u5206\u6790<\/span><\/strong><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u52a0\u62ff\u5927Precision Xtract\uff08\u5e02\u573a\u7814\u7a76\u673a\u6784\uff09\uff1b\u8bfa\u548c\u8bfa\u5fb7\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Current Medical Research and Opinion. 2018, 34(9):1595-1603.<\/span><\/p>\n

\u3010\u8bd5\u9a8c\u4e0e\/\u6216\u53d7\u8bd5\u8005\u57fa\u672c\u4fe1\u606f\u3011\u5171\u7eb3\u51658\u9879\u65f6\u957f\u226520\u5468\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011Semaglutide0.5 mg qw\u4e0e1.0 mg qw\u6539\u5584HbA1c\u7684\u6548\u679c\u663e\u8457\u4f18\u4e8eSGLT-2\u6291\u5236\u5242\uff0c\u5176\u4e2d\uff0cSemaglutide1.0 mg qw \u964d\u4f4eHbA1c\u7684\u6548\u679c\u4e0e\u5361\u683c\u5217\u51c0300 mg\u4e0e\u8fbe\u683c\u5217\u51c05 mg\u76f8\u6bd4\u7684MD\uff0895% CI\uff09\u5206\u522b\u4e3a-0.66%\uff08-0.82%~-0.50%\uff09\u4e0e-1.11%\uff08-1.37%~0.85%\uff09\u3002\u6b64\u5916\uff0cSemaglutide1.0 mg qw\u964d\u4f4e\u4f53\u91cd\u4e0e\u6539\u5584\u7a7a\u8179\u8840\u7cd6\u7684\u6548\u679c\u4e5f\u663e\u8457\u4f18\u4e8eSGLT-2\u6291\u5236\u5242\uff0c\u7136\u800c\u4e24\u8005\u964d\u4f4e\u6536\u7f29\u538b\u7684\u6548\u679c\u65e0\u663e\u8457\u7684\u5dee\u5f02\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u8bba\u3011\u5bf9\u4e8e\u5355\u72ec\u91c7\u7528\u4e8c\u7532\u53cc\u80cd\u6cbb\u7597\u6548\u679c\u6b20\u4f73\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u800c\u8a00\uff0cSemaglutideqw\u7684\u8840\u7cd6\u63a7\u5236\u6548\u679c\u663e\u8457\u4f18\u4e8eSGLT-2\u6291\u5236\u5242\u3002<\/span><\/p>\n

\uff084\uff09\u6bd4\u8f83\u65e2\u5f80\u91c7\u7528\u57fa\u7840\u80f0\u5c9b\u7d20\u6cbb\u7597\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5728\u57fa\u7840\u80f0\u5c9b\u7d20\u7684\u57fa\u7840\u4e0a\u6dfb\u52a0Semaglutide\u4e0e\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u6cbb\u7597\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u7684\u7cfb\u7edf\u6027\u6587\u732e\u8bc4\u4ef7\u4e0e\u7f51\u7edcMeta\u5206\u6790<\/span><\/strong><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u82f1\u56fdDRG Abacus\uff1b\u8bfa\u548c\u8bfa\u548c\u53c2\u4e0e\u5e76\u8d44\u52a9\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Diabetes Therapy. 2018, 9(3): 1233~1251\u3002<\/span><\/p>\n

\u3010\u8bd5\u9a8c\u4e0e\/\u6216\u53d7\u8bd5\u8005\u57fa\u672c\u4fe1\u606f\u3011\u5171\u7eb3\u5165\u4e868\u9879\u8bc4\u4ef7\u5728\u57fa\u7840\u80f0\u5c9b\u7d20\u7684\u57fa\u7840\u4e0a\u6dfb\u52a0Semaglutide\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u7684\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u63d0\u53d6\u6cbb\u7597\u540e24\u00b14\u5468\u7684\u6570\u636e\u8fdb\u884c\u5206\u6790\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011Semaglutide1.0 mg qw\u964dHbA1c\u4e0e\u51cf\u91cd\u7684\u6548\u679c\u5747\u663e\u8457\u4f18\u4e8e\u5bf9\u7167\uff0c\u5176MD\u5206\u522b\u4e3a-0.88%~1.39%\u4e0e-1.49kg~-4.69kg\u3002Semaglutide\u7ec4\u53d1\u751f\u6076\u5fc3\u3001\u5455\u5410\u6216\u8179\u6cfb\u4e0d\u826f\u53cd\u5e94\u7684\u6982\u7387\u4e0e\u6240\u6709\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u76f8\u4f3c\u3002\u4e0e\u5229\u62c9\u9c81\u80bd1.8 mg\u76f8\u6bd4\uff0cSemaglutide1.0 mg qw\u8fd8\u80fd\u6709\u6548\u5730\u964d\u4f4e\u7231\u624d\u7684\u6536\u7f29\u538b\u3002\u4f4e\u5242\u91cfSemaglutide\uff080.5 mg qw\uff09\u7684\u964dHbA1c\u6548\u679c\u663e\u8457\u4f18\u4e8e\u9664\u4e86\u5229\u62c9\u9c81\u80bd1.8 mg qd\u4ee5\u5916\u7684\u5176\u4ed6\u6240\u6709GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u5bf9\u7167\uff0c\u800c\u4e14\u4f4e\u5242\u91cfSemaglutide\u7ec4\u6076\u5fc3\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u7387\u4e5f\u663e\u8457\u4f4e\u4e8e\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u5bf9\u7167\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u8bba\u3011\u5728\u6240\u6709\u7684GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u4e2d\uff0cSemaglutide1.0 mg qw\u7528\u4f5c\u57fa\u7840\u80f0\u5c9b\u7d20\u7684\u6dfb\u52a0\u7597\u6cd5\u65f6\u964d\u4f4eHbA1c\u4e0e\u51cf\u91cd\u6548\u679c\u6700\u4f73\uff0c\u800c\u4e14\u5176\u6d88\u5316\u9053\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u7387\u4e5f\u4e0d\u9ad8\u4e8e\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u3002<\/span><\/p>\n

\uff085\uff09\u5728\u65e2\u5f80\u91c7\u75281~2\u79cd\u53e3\u670d\u964d\u7cd6\u836f\u6cbb\u7597\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\u6bd4\u8f83Semaglutide\u4e0e\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u7684\u7cfb\u7edf\u6027\u6587\u732e\u8bc4\u4ef7\u4e0e\u7f51\u7edcMeta\u5206\u6790<\/span><\/strong><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u82f1\u56fdDRG Abacus\uff1b\u8bfa\u548c\u8bfa\u548c\u53c2\u4e0e\u5e76\u8d44\u52a9\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Diabetes Therapy. 2018, 9(3): 1149~1167\u3002<\/span><\/p>\n

\u3010\u8bd5\u9a8c\u4e0e\/\u6216\u53d7\u8bd5\u8005\u57fa\u672c\u4fe1\u606f\u3011\u5171\u7eb3\u516526\u9879\u5728\u65e2\u5f80\u91c7\u75281~2\u79cd\u53e3\u670d\u964d\u7cd6\u836f\u6cbb\u7597\u4f46\u6548\u679c\u6b20\u4f73\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\u8bc4\u4ef7GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011Semaglutide1.0 mg qd\u964dHbA1c\u7684\u6548\u679c\u4e0e\u51cf\u91cd\u6548\u679c\u5747\u663e\u8457\u4f18\u4e8e\u6240\u6709\u7684GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u5bf9\u7167\uff0c\u800cSemaglutide0.5 mg qd\u7684\u4e0a\u8ff0\u6548\u679c\u5219\u4f18\u4e8e\u5927\u90e8\u5206\u7684GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u5bf9\u7167\u3002Semaglutide\u4e24\u4e2a\u5242\u91cf\u7ec4\u56e0\u4e0d\u826f\u53cd\u5e94\u800c\u9000\u51fa\u7814\u7a76\u7684\u53d7\u8bd5\u8005\u6240\u5360\u6bd4\u4f8b\u4e0e\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u76f8\u4f3c\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u5c31\u4f5c\u4e3a1~2\u79cd\u53e3\u670d\u964d\u7cd6\u836f\u7684\u6dfb\u52a0\u7597\u6cd5\u65f6\u4ece\u57fa\u7ebf\u81f3\u6cbb\u75976\u4e2a\u7684\u964dHbA1c\u6548\u679c\u4e0e\u51cf\u91cd\u6548\u679c\u800c\u8a00\uff0cSemaglutide1.0 mg qw\u662f\u6240\u6709GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u4e2d\u7684\u6700\u4f18\u8005\uff0c\u800c\u4e141.0 mg qw\u4e0e0.5 mg qw\u5747\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u7279\u5f81\uff0c\u4e14\u4e0d\u4f1a\u5347\u9ad8\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u800c\u5bfc\u81f4\u7684\u505c\u836f\u7387\u3002<\/span><\/p>\n

5.2 \u4e8b\u540e\u5206\u6790<\/span><\/strong><\/p>\n

\uff081\uff09SUSTAIN\u7cfb\u5217\u4e34\u5e8a\u8bd5\u9a8c\u4e2d2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4f7f\u7528Semaglutide\u6cbb\u7597\u5728\u907f\u514d\u589e\u91cd\u3001\u4f4e\u8840\u7cd6\u6216\u6d88\u5316\u9053\u4e0d\u826f\u53cd\u5e94\u4e8b\u4ef6\u800c\u5b9e\u73b0\u8840\u7cd6\u63a7\u5236\u6548\u679c\u7684\u4e8b\u540e\u5206\u6790<\/span><\/strong><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u8377\u5170\u5b66\u672f\u533b\u7597\u4e2d\u5fc3\uff1b\u5fb7\u56fdProfil\u4ee3\u8c22\u7814\u7a76\u6240\uff1b\u5185\u5e03\u62c9\u65af\u52a0\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\u7b49\u3002\u8bfa\u548c\u8bfa\u5fb7\u53c2\u4e0e\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Diabetes Obesity and Metabolism. 2018, 20(10): 2426~2434\u3002<\/span><\/p>\n

\u3010\u7814\u7a76\u4e0e\/\u6216\u53d7\u8bd5\u8005\u7279\u5f81\u3011SUSTAIN 1~5\u8bd5\u9a8c\u7684\u53d7\u8bd5\u8005\uff0c\u5176\u4e2d\uff0cSUSTAIN\u8bd5\u9a8c\u53d7\u8bd5\u8005\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u964d\u7cd6\u6cbb\u7597\uff0c\u800cSUSTAIN 2~5\u8bd5\u9a8c\u7684\u53d7\u8bd5\u8005\u5747\u6709\u964d\u7cd6\u836f\u7528\u836f\u53f2\uff0c\u5e76\u5c06\u5176\u65e2\u5f80\u7528\u836f\u4f5c\u4e3a\u8bd5\u9a8c\u4e2d\u7684\u80cc\u666f\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011SUSTAIN 1~5\u5404\u9879\u8bd5\u9a8c\u4e2d\uff0c\u5171\u67093918\u540d2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u968f\u673a\u5206\u5165Semaglutide0.5 mg qw\u30011.0 mg qw\uff08\u5747\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\uff09\u6216\u5bf9\u7167\u7ec4\uff08\u5305\u62ec\u5b89\u6170\u5242\u3001\u897f\u683c\u5217\u6c40100 mg\u3001\u7f13\u91ca\u827e\u585e\u90a3\u80bd2.0 mg\u7ec4\u6216\u7518\u7cbe\u80f0\u5c9b\u7d20\u7ec4\uff09\u3002Semaglutide0.5 mg qw\u7ec4\u3001Semaglutide1.0 mg qw\u7ec4\u3001\u5b89\u6170\u5242\u7ec4\u4e0e\u6d3b\u6027\u5bf9\u7167\u7ec4\u5b9e\u73b0HbA1c<7.0\u7684\u8840\u7cd6\u63a7\u5236\u76ee\u6807\u800c\u4e14\u672a\u53d1\u751f\u589e\u91cd\u6216\u75c7\u72b6\u6027\u4f4e\u8840\u7cd6\u7684\u53d7\u8bd5\u8005\u6240\u5360\u6bd4\u4f8b\u4f9d\u6b21\u4e3a47~66%\u300157~74%\u30017~19%\u4e0e16~29%\uff08\u5747P<0.0001\uff09\uff0c\u800c\u4e14Semaglutide\u4e24\u4e2a\u5242\u91cf\u7ec4\u5b9e\u73b0\u8840\u7cd6\u76ee\u6807\u800c\u4e14\u672a\u53d1\u751f\u4e2d\u5ea6\u6216\u91cd\u5ea6\u6d88\u5316\u9053\u4e0d\u826f\u53cd\u5e94\u7684\u53d7\u8bd5\u8005\u6240\u5360\u6bd4\u4f8b\u4e5f\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff08P<0.0001\uff09\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u8bba\u3011SUSTAIN 1~5\u8bd5\u9a8c\u4e2d\uff0cSemaglutide\u4e24\u4e2a\u5242\u91cf\u7ec4\u5185\u5b9e\u73b0HbA1c\u63a7\u5236\u76ee\u6807\u800c\u4e14\u672a\u53d1\u751f\u589e\u91cd\u3001\u4f4e\u8840\u7cd6\u6216\u6d88\u5316\u9053\u4e0d\u826f\u53cd\u5e94\u7684\u53d7\u8bd5\u8005\u6240\u5360\u6bd4\u4f8b\u5747\u9ad8\u4e8e\u5bf9\u7167\u3002<\/span><\/p>\n

\uff082\uff09SUSTAIN\u7cfb\u5217\u8bd5\u9a8c\u4e2dSemaglutide\u8001\u5e742\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7528\u836f\u7684\u4e8b\u540e\u5206\u6790<\/span><\/strong><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u5317\u5361\u7f57\u6765\u90a3\u533b\u5e08\u8054\u5408\u4f1a\uff1b\u4f5b\u7f57\u91cc\u8fbeMeridien\u7814\u7a76\u6240\u7b49\uff1b\u8bfa\u548c\u8bfa\u5fb7\u53c2\u4e0e\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Diabetes, Obesity and Metabolism. 2018, 20(9):2291~2297\u3002<\/span><\/p>\n

\u3010\u8bd5\u9a8c\u4e0e\/\u6216\u53d7\u8bd5\u8005\u57fa\u672c\u4fe1\u606f\u3011SUSTAIN 1~5\u8bd5\u9a8c\uff0c\u6309\u5e74\u9f84\u8fdb\u884c\u5206\u5c42\uff0c\u5305\u62ec\u975e\u8001\u5e74\u60a3\u80053045\u4eba\u4e0e\u8001\u5e74\u60a3\u8005854\u4eba<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011HbA1c\u7684\u6539\u5584\u6548\u679c\u5982\u4e0b\u8868\u6240\u793a\u3002<\/span><\/p>\n

\"Semaglutide\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

<\/span>Semaglutide\u5728\u5404\u5e74\u9f84\u7ec4\u7684\u51cf\u91cd\u4f5c\u7528\u76f8\u4f3c\u3002\u975e\u8001\u5e74\u60a3\u8005\u4e0e\u8001\u5e74\u60a3\u8005\u7684\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u76f8\u4f3c\uff0c\u8001\u5e74\u60a3\u8005\u4e2d\u56e0\u4e0d\u826f\u53cd\u5e94\u800c\u63d0\u524d\u9000\u51fa\u7814\u7a76\u7684\u53d7\u8bd5\u8005\u6240\u5360\u6bd4\u4f8b\u9ad8\u4e8e\u975e\u8001\u5e74\u60a3\u8005\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u8bba\u3011SUSTAIN 1~5\u8bd5\u9a8c\u4e2d\uff0cSemaglutide\u5728\u8001\u5e74\u60a3\u8005\u4e0e\u975e\u8001\u5e74\u60a3\u8005\u4e2d\u5177\u6709\u76f8\u4f3c\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\uff0c\u4f7f\u5f97\u8be5\u836f\u80fd\u7528\u4e8e\u8001\u5e742\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

\uff083\uff09SUSTAIN\u7cfb\u5217\u8bd5\u9a8c\u4e2dSemaglutide\u51cf\u91cd\u6548\u679c\u7684\u4e8b\u540e\u5206\u6790\uff08\u53d7\u8bd5\u8005\u6309\u57fa\u7ebfBMI\u6c34\u5e73\u4e0e\u662f\u5426\u53d1\u751f\u6d88\u5316\u9053\u4e0d\u826f\u53cd\u5e94\u8fdb\u884c\u5206\u5c42\uff09<\/span><\/strong><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u745e\u5178\u9686\u5fb7\u5927\u5b66\uff1b\u5a01\u5c14\u00b7\u5eb7\u5948\u5c14\u533b\u5b66\uff1b\u8bfa\u548c\u8bfa\u5fb7\u53c2\u4e0e\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Diabetes, Obesity and Metabolism. 2018, 20(9): 2010~2019<\/span><\/p>\n

\u3010\u8bd5\u9a8c\u4e0e\/\u6216\u53d7\u8bd5\u8005\u57fa\u672c\u4fe1\u606f\u3011SUSTAIN 1~5\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u5404BMI\u4e9a\u7ec4\u4eba\u7fa4\u7684\u51cf\u91cd\u6548\u679c\u5177\u6709\u4e34\u5e8a\u76f8\u5173\u6027\u7684\u7ec4\u95f4\u5dee\u5f02\uff0c\u5176\u4f53\u91cd\u7edd\u5bf9\u4e0b\u964d\u503c\u5448\u73b0\u51fa\u968f\u7740BMI\u589e\u957f\u800c\u4e0a\u5347\u7684\u8d8b\u52bf\u3002Semaglutide0.5 mg\u30011.0 mg \u7ec4\u4e0e\u5bf9\u7167\u7ec4\uff08\u5305\u62ec\u5b89\u6170\u5242\u3001\u897f\u683c\u5217\u6c40\u3001\u827e\u585e\u90a3\u80bd\u4e0e\u80f0\u5c9b\u7d20\uff09\u6076\u5fc3\u6216\u5455\u5410\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u7387\u4f9d\u6b21\u4e3a15.2~24.0%\u300121.5~27.2%\u4e0e6.0~14.1%\u3002Semaglutide\u4e0e\u5bf9\u7167\u7684\u51cf\u91cd\u6548\u679c\u4ec5\u67090.07~0.5 kg\u7684\u5dee\u503c\u7531\u6076\u5fc3\u6216\u5455\u5410\u6240\u4ecb\u5bfc\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u8bba\u3011\u5404\u57fa\u7ebfBMI\u6c34\u5e73\u7684\u4eba\u7fa4\u4e2d\uff0cSemaglutide\u7684\u51cf\u91cd\u6548\u679c\u5747\u663e\u8457\u4f18\u4e8e\u5bf9\u7167\uff0c\u800c\u6076\u5fc3\u6216\u5455\u5410\u5bf9\u51cf\u91cd\u6548\u679c\u4ec5\u6709\u5f88\u5c0f\u7684\u8d21\u732e\u3002<\/span><\/p>\n

\uff084\uff09SUSTAIN\u7cfb\u7edf\u8bd5\u9a8cSemaglutide\u7684\u7fa4\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u5206\u6790<\/span><\/strong><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u8bfa\u548c\u8bfa\u5fb7\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Diabetes Therapy. 2018, 9(4): 1533~1547\u3002<\/span><\/p>\n

\u3010\u8bd5\u9a8c\u4e0e\/\u6216\u53d7\u8bd5\u8005\u57fa\u672c\u4fe1\u606f\u3011SUSTAIN 1\u30012\u30013\u30016\u8bd5\u9a8c\u4e0eSUSTAIN-JAPAN\u8bd5\u9a8c\uff0c\u5171\u7eb3\u51651612\u540d\u6700\u591a\u63a5\u53d77\u6b21\u836f\u4ee3\u52a8\u529b\u5b66\u8bc4\u4ef7\u7684\u53d7\u8bd5\u8005\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u3011\u6027\u522b\u3001\u5e74\u9f84\u3001\u4eba\u79cd\u3001\u79cd\u65cf\u3001\u80be\u529f\u80fd\u4e0e\u6ce8\u5c04\u90e8\u4f4d\u7b49\u53d8\u91cf\u5bf9Semaglutide\u7684\u66b4\u9732\u6c34\u5e73\u5747\u65e0\u4e34\u5e8a\u76f8\u5173\u6027\u7684\u5f71\u54cd\uff0c\u4ec5\u53d7\u8bd5\u8005\u4f53\u91cd\u5bf9Semaglutide\u7684\u4f53\u91cd\u66b4\u9732\u6c34\u5e73\u5b58\u5728\u4e34\u5e8a\u76f8\u5173\u6027\u7684\u5f71\u54cd\u3002\u5c11\u6570\u60a3\u8005\u4f53\u5185\u4ea7\u751fSemaglutide\u6297\u4f53\uff0c\u800c\u4e14\u8be5\u6297\u4f53\u5bf9Semaglutide\u7684\u66b4\u9732\u6c34\u5e73\u65e0\u5f71\u54cd\u3002Semaglutide\u76840.5 mg\u4e0e1.0 mg\u5b58\u5728\u6709\u5242\u91cf\u6bd4\u4f8b\u5173\u7cfb\u3002<\/span><\/p>\n

\uff085\uff09\u8bc4\u4ef7SUSTAIN\u7cfb\u5217\u8bd5\u9a8c\u4e2d\u53d7\u8bd5\u8005\u4ece\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u6362\u7528Semaglutide\u540e\u5bf9\u5176HbA1c\u4e0e\u4f53\u91cd\u7684\u5f71\u54cd\u7684\u4e8b\u4ef6\u5206\u6790<\/span><\/strong><\/p>\n

\u3010\u7814\u7a76\u673a\u6784\u3011\u8bfa\u548c\u8bfa\u5fb7\u3002<\/span><\/p>\n

\u3010\u51fa\u5904\u3011Diabetes, Obesity and Metabolism. 2018, 7\u670825\u65e5\uff08\u63d0\u524d\u53d1\u8868\uff09\u3002<\/span><\/p>\n

\u3010\u8bd5\u9a8c\/\u53d7\u8bd5\u8005\u57fa\u672c\u4fe1\u606f\u3011SUSTAIN\u7cfb\u5217\u8bd5\u9a8c\u4e2d\u76844\u9879\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u679c\u30112\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4ece\u5176\u4ed6GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u6362\u7528Semaglutide\u540e\uff0c\u6548\u80fd\u8c03\u6574\u540e\u7684GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u603b\u6709\u6548\u6d53\u5ea6\u5c0f\u6709\u6240\u4e0a\u5347\uff0c\u800cSemaglutide1.0 mg\u7ec4\u53d7\u8bd5\u8005HbA1c\u4e0e\u4f53\u91cd\u5206\u522b\u8fdb\u4e00\u6b65\u4e0b\u964d0.3%~0.8%\u4e0e2~4%\u3002\u4ece\u5229\u62c9\u9c81\u80bd1.2 mg\/1.8 mg\u6216\u5ea6\u62c9\u9c81\u80bd1.5 mg\u6362\u7528Semaglutide0.25 mg\u80fd\u4f7fHbA1c\u51fa\u73b0\u6682\u65f6\u6027\u7684\u8f7b\u5fae\u6076\u5316\u3002<\/span><\/p>\n

\u3010\u4e3b\u8981\u7ed3\u8bba\u30112\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4ece\u5229\u62c9\u9c81\u80bd\u3001\u5ea6\u62c9\u9c81\u80bd\u6216\u7f13\u91ca\u827e\u585e\u90a3\u80bd\u6362\u7528Semaglutide\u53ef\u4f7f\u5176HbA1c\u4e0e\u4f53\u91cd\u8fdb\u4e00\u6b65\u964d\u4f4e\u3002\u800c\u91c7\u7528\u8f83\u9ad8\u7684Semaglutide\u8d77\u59cb\u5242\u91cf\u5219\u53ef\u6709\u6548\u5730\u907f\u514d\u6362\u7528Semaglutide0.25mg\u6240\u51fa\u73b0\u7684\u8f7b\u5ea6HbA1c\u6076\u5316\u73b0\u8c61\u3002<\/span><\/p>\n

6<\/strong><\/span>\u603b\u7ed3\u4e0e\u611f\u60f3<\/span><\/span><\/strong><\/p>\n

\u9664\u4e86\u5df2\u7ecf\u6536\u5f55\u4e8eDrug Labelling\u4e2d\u7684SUSTAIN\u7cfb\u5217\u8bd5\u9a8c\u4e0e\u9646\u7eed\u516c\u5e03\u7ed3\u679c\u7684PIONEER\u7cfb\u5217\u8bd5\u9a8c\uff0c\u8bfa\u548c\u8bfa\u5fb7\u8fd8\u9488\u5bf9Semaglutide\u5f00\u5c55\u7684\u4e00\u7cfb\u5217\u7684\u4e0a\u5e02\u540e\u4e34\u5e8a\u8bc4\u4ef7\uff0c\u5e76\u79ef\u6781\u53c2\u4e0e\u8bd5\u9a8c\u6570\u636e\u7684\u518d\u8bc4\u4ef7\u5206\u6790\u53ca\u836f\u7269\u7ecf\u6d4e\u5b66\u7814\u7a76\uff0c\u8fdb\u4e00\u6b65\u5de9\u56faSemaglutide\u5728\u964d\u7cd6\u6548\u679c\u3001\u51cf\u91cd\u6548\u679c\u4ee5\u53ca\u6210\u672c-\u6548\u76ca\u7279\u5f81\u7b49\u65b9\u9762\u4e0e\u5176\u4ed6\u964d\u7cd6\u836f\uff0c\u7279\u522b\u662f\u540c\u7c7b\u7684\u957f\u6548GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u7684\u4f18\u8d8a\u6027\u3002<\/span>
<\/span><\/p>\n

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\"Semaglutide\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

\"Semaglutide\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u8fdb\u5c55\"\"Semaglutide\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

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