{"id":64853,"date":"2018-11-22T01:00:00","date_gmt":"2018-12-07T03:43:25","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/1ea96efbc5\/"},"modified":"2018-12-07T11:43:26","modified_gmt":"2018-12-07T03:43:26","slug":"1ea96efbc5","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/64853\/","title":{"rendered":"2024\u5e74\u5341\u5927\u80bf\u7624\u836f\u5236\u9020\u5546\u5927\u9884\u6d4b"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  class=\"_135editor\" style=\"font-size: 16px;white-space: normal;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-color: currentcolor;border-style: none;border-width: 0px;box-sizing: border-box;\">\n<section class=\"_135editor\"     style=\"border-color: currentcolor;border-style: none;border-width: 0px;box-sizing: border-box;\">\n<section class=\"135brush\"  placeholder=\"\u6df1\u8272\u8fb9\u6846\u6807\u9898\" style=\"margin-top: 10px;margin-bottom: 10px;padding: 10px;line-height: 25px;color: rgb(109, 4, 14);border-top-left-radius: 4px;border-top-right-radius: 4px;border-bottom-right-radius: 4px;border-bottom-left-radius: 4px;box-shadow: rgb(153, 153, 153) 2px 2px 4px 0px;border-left-width: 10px;border-left-style: solid;border-color: rgb(21, 59, 143);background-color: rgb(225, 227, 226);box-sizing: border-box;\">\n<p style=\"margin-top: 5px;margin-bottom: 5px;padding-right: 10px;padding-left: 10px;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"text-align: justify;color: rgb(0, 0, 0);text-indent: 0em;font-size: 15px;\">\u7ec6\u8bfb\u5168\u7403\u836f\u54c1\u5e02\u573a\u8c03\u67e5\u673a\u6784EvaluatePharma\uff08\u4ee5\u4e0b\u7b80\u79f0EP\uff09\u7684\u9884\u8ba1\u62a5\u544a\uff0c2024\u5e74\u6297\u764c\u836f\u5236\u9020\u5546Top10\u4e0e2017\u5e74\u7684\u699c\u5355\u4f3c\u4e4e\u65e0\u591a\u5927\u53d8\u5316\uff0c\u6392\u540d\u524d\u4e09\u7684\u7f57\u6c0f\uff0c\u65b0\u57fa\u548c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u5730\u4f4d\u4e0d\u4f1a\u52a8\u6447\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"font-size: 16px;white-space: normal;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-color: currentcolor;border-style: none;border-width: 0px;box-sizing: border-box;\">\n<section  style=\"padding-right: 5px;display: inline-block;width: 558px;border-width: 0px 10px 1px 0px;border-style: solid;border-bottom-color: rgb(27, 58, 149);border-left-color: rgb(27, 58, 149);border-right-color: rgb(27, 58, 149);border-bottom-left-radius: 0px;border-top-right-radius: 0px;box-sizing: border-box;\">\n<section style=\"text-align: right;transform: translate3d(0px, 0px, 0px);\">\n<p class=\"135brush\" >&nbsp;\u5168\u65875942\u5b57\uff0c\u7528\u65f612\u5206\u949f<\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;text-align: justify;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4f5c\u8005\uff1a\u8bb8\u5173\u715c\u3001\u674e\u654f\u534e<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u7ec6\u8bfb\u5168\u7403\u836f\u54c1\u5e02\u573a\u8c03\u67e5\u673a\u6784EvaluatePharma\uff08\u4ee5\u4e0b\u7b80\u79f0EP\uff09\u7684\u9884\u8ba1\u62a5\u544a\uff0c2024\u5e74\u6297\u764c\u836f\u5236\u9020\u5546Top10\u4e0e2017\u5e74\u7684\u699c\u5355\u4f3c\u4e4e\u65e0\u591a\u5927\u53d8\u5316\uff0c\u6392\u540d\u524d\u4e09\u7684\u7f57\u6c0f\uff0c\u65b0\u57fa\u548c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u5730\u4f4d\u4e0d\u4f1a\u52a8\u6447\u3002\u4f46\u6392\u540d\u4e0d\u80fd\u8bf4\u660e\u672a\u6765\u53d1\u5c55\uff0c\u56e0\u4e3a\u867d\u7136\u8fd9\u4e09\u5bb6\u516c\u53f8\u6ca1\u6709\u906d\u9047\u5927\u4f4d\u4e0d\u4fdd\u7684\u5883\u5730\uff0c\u4f46\u5b83\u4eec\u7684\u5e02\u573a\u4efd\u989d\u5e76\u4e0d\u80fd\u7ee7\u7eed\u7ef4\u6301\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u56de\u987e2017\u5e74\u62a5\u544a\uff0c\u8fd9\u4e09\u5bb6\u5de8\u5934\u5171\u540c\u5360\u636e\u4e86\u80bf\u7624\u836f45.8\uff05\u5e02\u573a\u4efd\u989d\uff0c\u957f\u671f\u7684\u9886\u5bfc\u8005\u7f57\u6c0f\u72ec\u5360\u4e8626.4\uff05\u3002\u7136\u800c\u52302024\u5e74\uff0cEP\u9884\u8ba1\u4f1a\u6709\u201c\u5747\u52bf\u201d\u51fa\u73b0\u3002\u6392\u540d\u524d\u4e09\u7684\u4efd\u989d\u5c06\u840e\u7f29\u81f326.2\uff05\uff0c\u7f57\u6c0f\u7684\u4efd\u989d\u8dcc\u81f311.9\uff05\u3002\u6392\u540d\u7b2c\u4e8c\u5230\u7b2c\u4e94\u7684\u516c\u53f8\u4f9d\u6b21\u4e3a\uff1a\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff0c\u5f3a\u751f\uff0c\u8f89\u745e\uff0c\u963f\u65af\u5229\u5eb7\u548c\u9ed8\u514b\uff0c\u76f8\u4e92\u7684\u5dee\u522b\u5c06\u5728\u4e0d\u5230\u4e00\u4e2a\u767e\u5206\u70b9\u7684\u8303\u56f4\u5185\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u5e76\u4e14\u5e76\u975e\u662f\u201c\u5c40\u5916\u201d\u7684\u5236\u836f\u5546\u4f5c\u4e3a\u201c\u7b28\u62d9\u201d\u7684\u7403\u624b\u5076\u7136\u6293\u4f4f\u4e00\u5757\u201c\u9985\u997c\u201d\u3002\u53bb\u5e74\uff0c\u6392\u540d\u524d10\u4f4d\u4e4b\u5916\u7684\u516c\u53f8\u4ec5\u5360\u636e\u4e8621.5\uff05\u5e02\u573a\u4efd\u989d\u3002\u52302024\u5e74\uff0c\u8fd9\u4e2a\u6570\u5b57\u5c06\u589e\u52a0\u8fd1\u4e00\u500d\uff0c\u589e\u957f\u81f339.7\uff05\uff0c\u8fd9\u5f52\u56e0\u4e8e\u8fd1\u5e74\u5409\u5229\u5fb7\u79d1\u5b66\uff0c\u5229\u6765\uff0cTesaro\uff0cClovis\uff08\u514b\u6d1b\u7ef4\u65af\uff09\u7b49\u516c\u53f8\u52a0\u5165\u3002\u8fd9\u5bf9\u4e8e\u5df2\u7ecf\u662f\u8d85\u7ea7\u7ade\u4e89\u7684\u80ba\u764c\u9886\u57df\u6765\u8bf4\u610f\u5473\u7740\u7ade\u4e89\u5c06\u53d8\u5f97\u66f4\u52a0\u6fc0\u70c8\u3002<\/span><\/p>\n<section  class=\"_135editor\" style=\"white-space: normal;border-color: currentcolor;border-style: none;border-width: 0px;box-sizing: border-box;\">\n<p style=\"margin-top: 8px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: #003472;color: #003472;\"><span class=\"autonum\" style=\"margin-right: 8px;padding: 4px 10px;background-color: #003472;color: #fefefe;display: block;float: left;line-height: 20px;\"><strong>1<\/strong><\/span><strong>\u7f57\u6c0f<\/strong><\/p>\n<\/section>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u6297\u764c\u836f\u9500\u552e\u989d\uff1a2017-274.5\u4ebf\u7f8e\u5143\uff1b2024\u9884\u8ba1-278.2\u4ebf\u7f8e\u5143\uff08\u540d\u6b21\u4e0d\u53d8\uff09<br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u6839\u636eEP\u7684\u9884\u6d4b\uff0c\u7f57\u6c0f\u5728\u6297\u764c\u836f\u5e02\u573a\u4e4b\u9996\u7684\u5730\u4f4d\u73b0\u5728\u548c2024\u5e74\u4e4b\u95f4\u4e0d\u4f1a\u51fa\u73b0\u4efb\u4f55\u5f71\u54cd\uff0c\u5176\u9500\u552e\u6570\u636e\u4e5f\u4e0d\u4f1a\u5728\u6b64\u671f\u95f4\u53d1\u751f\u592a\u5927\u53d8\u5316\u3002\u4f46\u5b83\u7684\u5e02\u573a\u4efd\u989d\u5c06\u4e0b\u6ed1\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u591a\u5e74\u6765\u4e00\u76f4\u4e3b\u5bfc\u764c\u75c7\u6cbb\u7597\u9886\u57df\u7684\u8fd9\u5bb6\u745e\u58eb\u5236\u836f\u5546\u7684\u9886\u5148\u5730\u4f4d\u5373\u5c06\u6d88\u8680\u30022017\u5e74\uff0c\u5176\u5e02\u573a\u4efd\u989d\u5df2\u4ece26.4\uff05\u4e0b\u964d\u81f311.9\uff05\uff0c\u56e0\u4e3a\u6765\u81eaTop10\u4e2d\u7684\u524d6\u5bb6\u7ade\u4e89\u5bf9\u624b\uff09\u5f3a\u751f\uff0c\u8f89\u745e\uff0c\u963f\u65af\u5229\u5eb7\uff0c\u9ed8\u514b\uff0c\u827e\u4f2f\u7ef4\u548c\u5b89\u65af\u6cf0\u6765\u7684\u9500\u552e\u989d\u5448\u73b0\u4e24\u4f4d\u6570\u589e\u957f\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u7f57\u6c0f\u5373\u5c06\u906d\u9047\u7684\u9500\u552e\u505c\u6ede\u7684\u4e00\u5927\u90e8\u5206\u662f\u751f\u7269\u4eff\u5236\u836f\u7ade\u4e89\u5bf9\u624b\uff0cRituxan\uff08Rituximab\uff0c\u5229\u59a5\u6614\u5355\u6297\uff09\uff0cHerceptin\uff08Trastuzumab\uff0c\u66f2\u59a5\u73e0\u5355\u6297\/\u8d6b\u8d5b\u6c40\uff09\u548cAvastin\uff08Bevacizumab\uff0c\u8d1d\u4f10\u73e0\u5355\u6297\/\u5b89\u7ef4\u6c40\uff09\u7684\u62f7\u8d1d\u4ea7\u54c1\u5c06\u5728\u672a\u6765\u51e0\u5e74\u8fdb\u5165\u5e02\u573a\uff0c\u5176\u4e2d\u67d0\u4e9b\u5df2\u7ecf\u5728\u6d77\u5916\u4e0a\u5e02\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4e3a\u4e86\u586b\u8865\u6536\u5165\u7684\u635f\u5931\uff0c\u7f57\u6c0f\u6b63\u5728\u5bfb\u7403\u4ee5\u514d\u75ab\u80bf\u7624\u4ea7\u54c1Tecentriq\uff08Atezolizumab\uff09\u66ff\u8865\uff0c\u8be5\u836f\u76ee\u524d\u5728\u80ba\u764c\u548c\u8180\u80f1\u764c\u6cbb\u7597\u65b9\u9762\u83b7\u5f97\u6279\u51c6\u3002\u6709\u4e00\u4e2a\u95ee\u9898\uff1a\u5b83\u7684\u7ade\u4e89\u5bf9\u624b\u4e5f\u5728\u8fd9\u6837\u505a\uff0c\u6709\u5206\u6790\u5e08\u8ba4\u4e3a\u7f57\u6c0f\u7684\u6570\u636e\u4f3c\u4e4e\u5e76\u4e0d\u80fd\u4e0e\u7ade\u4e89\u5bf9\u624b\u9ed8\u514b\u516c\u53f8\u5728\u6700\u91cd\u8981\u7684\u4e00\u7ebf\u80ba\u764c\u5e02\u573a\u4e0a\u5e73\u8d77\u5e73\u5750\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4e0d\u8fc7\uff0c\u8fd9\u5e76\u4e0d\u662f\u8bf4\u8be5\u836f\u65e0\u6cd5\u627e\u5230\u5176\u5b83\u5e02\u573a\uff0c\u6700\u8fd1\u7684\u8bd5\u9a8c\u7ed3\u679c\u663e\u793aTecentriq\u53ef\u80fd\u83b7\u5f97\u4e00\u4e9b\u91cd\u8981\u5546\u673a\u3002\u7f57\u6c0f\u8868\u793a\uff0c9\u6708\u4efd\uff0cTecentriq\u4f7f\u60a3\u6709\u5e7f\u6cdb\u671f\uff08extensive-stage\uff09\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u60a3\u8005\u7684\u751f\u547d\u5e73\u5747\u5ef6\u957f\u4e8612.3\u4e2a\u6708\uff0c\u800c\u5355\u72ec\u5316\u7597\u5219\u4e3a10.3\u4e2a\u6708\uff1b\u5206\u6790\u5e08\u8ba4\u4e3a\uff0c\u6cbb\u7597\u8be5\u60a3\u8005\u4eba\u7fa4\u7684\u6279\u51c6\u53ef\u80fd\u9500\u552e\u989d\u4f1a\u8fbe\u523015\u4ebf\u7f8e\u5143\u3002\u4eca\u5e747\u6708\u62a5\u9053\uff0cTecentriq\u5728\u96be\u4ee5\u6cbb\u7597\u7684\u4e09\u9634\u6027\u4e73\u817a\u764c\u8bd5\u9a8c\u4e2d\u83b7\u5f97\u6210\u529f\uff0c\u53ef\u80fd\u6210\u4e3a\u540c\u7c7b\u4e2d\u7b2c\u4e00\u4e2a\u83b7\u51c6\u8be5\u9002\u5e94\u75c7\u7684\u4ea7\u54c1\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u7f57\u6c0f\u8fd8\u5e0c\u671b\u901a\u8fc7\u7ec4\u5408\u4e3a\u5176\u539f\u6709\u4ea7\u54c1\u5bfb\u627e\u65b0\u7684\u9500\u552e\u9014\u5f84\u3002\u4f8b\u5982\u5728\u80ba\u764c\u548c\u809d\u764c\u7b49\u9886\u57df\u5c06Tecentriq\u548cAvastin\u201c\u914d\u5bf9\u201d\u3002\u53bb\u5e74\u5b83\u7684Herceptin\u548c\u65b0\u4e73\u817a\u764c\u6cbb\u7597Perjeta\u7ec4\u5408\u7528\u4e8e\u624b\u672f\u540e\u60a3\u8005\u83b7\u5f97FDA\u6279\u51c6\u3002<\/span><\/p>\n<section  class=\"_135editor\" style=\"white-space: normal;border-color: currentcolor;border-style: none;border-width: 0px;box-sizing: border-box;\">\n<p style=\"margin-top: 8px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: #003472;color: #003472;\"><span class=\"autonum\" style=\"margin-right: 8px;padding: 4px 10px;background-color: #003472;color: #fefefe;display: block;float: left;line-height: 20px;\"><strong>2<\/strong><\/span><strong>\u65b0\u57fa<\/strong><\/p>\n<\/section>\n<p style=\"text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u6297\u764c\u836f\u9500\u552e\u989d\uff1a2017-116.5\u4ebf\u7f8e\u5143\uff1b2024\u9884\u8ba1-185.5\u4ebf\u7f8e\u5143\uff08\u540d\u6b21\u4e0d\u53d8\uff09<br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u8c08\u5230\u65b0\u57fa\u7684\u6297\u764c\u836f\u7ec4\u5408\u53ca\u5176\u4ea7\u54c1\u6574\u4f53\u7ec4\u5408\uff0cRevlimid\uff08Lenalidomide\uff0c\u6765\u90a3\u5ea6\u80fa\/\u745e\u590d\u7f8e\uff09\u662f\u8be5\u516c\u53f8\u7684\u4e00\u5f20\u738b\u724c\u3002\u53bb\u5e74\uff0c\u8fd9\u4e2a\u8d85\u7ea7\u91cd\u78c5\u836f\u54c1\u83b7\u5f97\u4e8682\u4ebf\u7f8e\u5143\u7684\u9500\u552e\u989d\uff0c\u5e76\u4e142018\u5e74\u6709\u671b\u8d85\u8fc7\u8fd9\u4e00\u6570\u5b57\uff0c\u4eca\u5e74\u524d9\u4e2a\u6708\u5df2\u7ecf\u8fbe\u523071.4\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u5f53\u7136\uff0c\u8be5\u836f\u5e76\u975e\u4e8b\u4e8b\u5982\u610f\u3002\u53bb\u5e7412\u6708\uff0c\u8be5\u516c\u53f8\u62ab\u9732\uff0c\u5728\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u8bd5\u9a8c\u4e2d\uff0c\u5b83\u6ca1\u6709\u8fbe\u5230\u76ee\u6807\uff0c\u539f\u5148\u9884\u8ba1\u81f32022\u5e74\u9760\u8fd9\u4e2a\u65b0\u9002\u5e94\u75c7\u5e26\u67655\u4ebf\u7f8e\u5143\u7684\u5e74\u5ea6\u9500\u552e\u989d\u7684\u8ba1\u5212\u81ea\u7136\u4ed8\u4e4b\u4e1c\u6d41\u3002\u6295\u8d44\u8005\u5df2\u7ecf\u5f00\u59cb\u5173\u6ce8\u751f\u7269\u4eff\u5236\u836f\u5c06\u5bf9Revlimid\u7684\u9500\u552e\u6307\u51fa\u4ec0\u4e48\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u7136\u800c\uff0c\u65b0\u57fa\u6b63\u5728\u7269\u8272\u201c\u540e\u8d77\u4e4b\u79c0\u201d\u6765\u586b\u8865\u8fd9\u4e00\u635f\u5931\uff0c\u5728\u6b64\u671f\u95f4\uff0c\u522b\u7684\u65b0\u836f\u4e5f\u6b63\u5728\u8695\u98dfRevlimid\u7684\u5e02\u573a\u3002\u53bb\u5e74\u590f\u5929\uff0c\u8fd9\u5bb6\u4f4d\u4e8e\u65b0\u6cfd\u897f\u5dde\u7684\u5236\u836f\u5546\u548c\u5408\u4f5c\u4f19\u4f34Agios\u7684Idhifa\uff08Enasidenib\uff0c\u6069\u897f\u5730\u5e73\uff09\u83b7FDA \u6279\u51c6\uff0c\u7528\u4e8e\u590d\u53d1\/\u96be\u6cbb\u6027IDH2\u7a81\u53d8\u96be\u6cbb\u6027\u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff08AML\uff09\u60a3\u8005\u3002\u8be5\u60a3\u8005\u7fa4\u4f53\u5360\u6240\u6709AML\u60a3\u8005\u4eba\u6570\u76848\uff05\u81f319\uff05\uff0c\u800cIdhifa\u662f\u7b2c\u4e00\u4e2a\u6cbb\u7597\u6b64\u7c7b\u60a3\u8005\u7684\u53e3\u670d\u9776\u5411\u6291\u5236\u5242\u3002\u65b0\u57fa\u516c\u53f8\u9884\u8ba1\u5c06\u7531\u6b64\u83b7\u5f975\u4ebf\u7f8e\u5143\u6536\u5165\u3002Vidaza\uff08Azacitidine\uff0c\u963f\u624e\u80de\u82f7\uff09\uff0c\u4e5f\u5728AML\u9886\u57df\u53d1\u6325\u4f5c\u7528\uff0c\u4eca\u5e74\u524d9\u4e2a\u6708\u4e3a\u5176\u5e26\u6765\u4e864.58\u4ebf\u7f8e\u5143\u6536\u5165\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">Pomalyst\uff08Pomalidomide\uff0c\u6cca\u9a6c\u5ea6\u80fa\uff09\u662f\u65b0\u57fa\u516c\u53f8\u53e6\u4e00\u4e2a\u91cd\u78c5\u4ea7\u54c1\uff0c\u5b83\u4e0e\u5176\u201c\u5927\u54e5\u201dRevlimid\u4e00\u8d77\u5728\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7ade\u6280\u573a\u53d1\u529b\u3002\u4eca\u5e74\u524d9\u4e2a\u6708\uff0c\u5b83\u7684\u9500\u552e\u989d\u5df2\u8fbe14.7\u4ebf\u7f8e\u5143\u3002\u65b0\u57fa\u4e5f\u6709CAR-T\u7597\u6cd5\u5728\u9aa8\u9ad3\u7624\u9886\u57df\u8fdb\u884c\u4e34\u5e8a\uff0c\u6700\u7ec8\u53ef\u671b\u5f25\u8865Pomalyst\u7684\u8870\u843d\u3002<\/span><\/p>\n<section  class=\"_135editor\" style=\"white-space: normal;border-color: currentcolor;border-style: none;border-width: 0px;box-sizing: border-box;\">\n<p style=\"margin-top: 8px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: #003472;color: #003472;\"><span class=\"autonum\" style=\"margin-right: 8px;padding: 4px 10px;background-color: #003472;color: #fefefe;display: block;float: left;line-height: 20px;\"><strong>3<\/strong><\/span><strong>\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d<\/strong><\/p>\n<\/section>\n<p style=\"text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u6297\u764c\u836f\u9500\u552e\u989d\uff1a2017-85.2\u4ebf\u7f8e\u5143\uff1b2024\u9884\u8ba1-147.1\u4ebf\u7f8e\u5143\uff08\u540d\u6b21\u4e0d\u53d8\uff09<br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u66fe\u51e0\u4f55\u65f6\uff0c\u884c\u4e1a\u89c2\u5bdf\u4eba\u58eb\u9884\u6d4b\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u516c\u53f8\u7684Opdivo\uff08Nivolumab\uff0c\u5c3c\u9c81\u5355\u6297\uff09\u5c06\u53d6\u4ee3\u9ed8\u514b\uff08\u9ed8\u6c99\u4e1c\uff09\u7684Keytruda\uff08Pembrolizumab\uff0c\u6d3e\u59c6\u5355\u6297\uff09\u6210\u4e3aPD-1 \/ PD-L1\u514d\u75ab\u80bf\u7624\u836f\u7269\u7684\u9886\u5934\u7f8a\u3002\u7136\u800c\uff0c\u73b0\u4eca\uff0c\u90a3\u65f6\u7684\u611f\u89c9\u5c31\u50cf\u9065\u8fdc\u7684\u8bb0\u5fc6\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u7531\u4e8e\u5728\u4e4b\u524d\u672a\u7ecf\u6cbb\u7597\u7684\u80ba\u764c\u9886\u57df\u53d1\u751f\u4e86\u4e00\u7cfb\u5217\u8bd5\u9a8c\u6027\u4e8b\u6545\uff0cOpdivo\u5df2\u7ecf\u843d\u540e\u4e8e\u5176\u7ade\u4e89\u5bf9\u624b\uff0c\u800cKeytruda\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4e00\u518d\u53d6\u5f97\u6210\u529f\u7684\u4e8b\u5b9e\u4e5f\u6ca1\u80fd\u5bf9\u8be5\u516c\u53f8\u6709\u591a\u5927\u5e2e\u52a9\u3002\u5728\u5229\u6da6\u4e30\u539a\u7684\u4e00\u7ebf\u5e02\u573aKeytruda\u5df2\u7ecf\u83b7\u5f97\u4e86\u4e24\u9879\u6279\u51c6\uff0c\u4f46\u4e00\u4e9b\u5206\u6790\u5e08\u6700\u8fd1\u8868\u793a\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u53ef\u80fd\u8fd8\u9700\u8981\u4e00\u5e74\u6216\u66f4\u957f\u7684\u65f6\u95f4\u624d\u80fd\u8fbe\u5230\u5176\u4e2d\u4e00\u4e2a\u76ee\u6807\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u5f53\u7136\uff0c\u8fd9\u5e76\u975e\u8bf4\u8be5\u836f\u5728\u5176\u5b83\u8bb8\u591a\u4e3b\u8981\u5e02\u573a\u90fd\u6ca1\u6709\u4f5c\u4e3a\u3002\u5b83\u4e0e\u65bd\u8d35\u5b9d\u539f\u6709\u7684\u68c0\u6d4b\u70b9\u6291\u5236\u5242CTLA4\u836f\u7269Yervoy\uff08Ipilimumab,\uff0c\u4f0a\u5339\u5355\u6297\uff09\u7ec4\u5408\uff0c\u4f7f\u8fd9\u4e24\u79cd\u836f\u5728\u521d\u6cbb\u7684\u9ed1\u8272\u7d20\u7624\u3001\u4ee5\u524d\u672a\u4f5c\u6cbb\u7597\u7684\u80be\u764c\u7b49\u9886\u57df\u83b7\u5f97\u6279\u51c6\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u5728\u514d\u75ab\u80bf\u7624\u5b66\u9886\u57df\u4e4b\u5916\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u62e5\u6709\u767d\u8840\u75c5\u836f\u7269Sprycel\uff08Dasatinib\uff0c\u8fbe\u6c99\u66ff\u5c3c\uff09\u548c\u66f4\u65b0\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7ade\u4e89\u836f\u54c1Empliciti\uff08Elotuzumab\uff0c\u57c3\u7f57\u59a5\u73e0\u5355\u6297\uff09\u3002\u867d\u7136\u9aa8\u9ad3\u7624\u7684\u7a7a\u95f4\u7279\u522b\u62e5\u6324\u2014\u2014\u5f3a\u751f\u516c\u53f8\u7684Darzalex\uff08Daratumumab\uff0c\u8fbe\u96f7\u6728\u5355\u6297\uff09\u548c\u6b66\u7530\u7684Ninlaro\uff08Ninlaro\uff0c\u827e\u6c99\u4f50\u7c73\uff09\u4e0eEmpliciti\u5dee\u4e0d\u591a\u65f6\u95f4\u83b7\u51c6\uff0c\u4f46\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u548c\u5408\u4f5c\u4f19\u4f34\u827e\u4f2f\u7ef4\u8d70\u5728\u524d\u9762\u30028\u6708\uff0c\u7f8e\u56fdFDA\u7ed9\u4e88\u8be5\u836f\u4f5c\u4e3a\u9e21\u5c3e\u9152\u7684\u7ec4\u5206\u4ee5\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u8be5\u9e21\u5c3e\u9152\u7684\u5176\u5b83\u7ec4\u5206\u6709\u65b0\u57fa\u7684Pomalyst\uff08pomalidomide\uff0c\u6cca\u9a6c\u5ea6\u80fa\uff09\u548c\u4f4e\u5242\u91cf\u5730\u585e\u7c73\u677e\uff08dexamethasone\uff09\uff0c\u7528\u4e8e\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e24\u6b21\u6cbb\u7597\u7684\u590d\u53d1\u548c\u96be\u6cbb\u6027\u60a3\u8005\u3002<\/span><\/p>\n<section  class=\"_135editor\" style=\"white-space: normal;border-color: currentcolor;border-style: none;border-width: 0px;box-sizing: border-box;\">\n<p style=\"margin-top: 8px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: #003472;color: #003472;\"><span class=\"autonum\" style=\"margin-right: 8px;padding: 4px 10px;background-color: #003472;color: #fefefe;display: block;float: left;line-height: 20px;\"><strong>4<\/strong><\/span><strong>\u5f3a\u751f<\/strong><\/p>\n<\/section>\n<p style=\"text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u6297\u764c\u836f\u9500\u552e\u989d\uff1a2017-61.5\u4ebf\u7f8e\u5143\uff1b2024\u9884\u8ba1-143.1\u4ebf\u7f8e\u5143\uff08\u540d\u6b21\u63d0\u53471\u4f4d\uff09<br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u5f3a\u751f\u516c\u53f8\u53ef\u80fd\u6ca1\u6709\u50cf\u5176\u7ade\u4e89\u5bf9\u624b\u90a3\u6837\u6709\u5e7f\u6cdb\u7684\u80bf\u7624\u5b66\u4ea7\u54c1\u7ec4\u5408\uff0c\u4f46\u5b83\u7684\u4ea7\u54c1\u662f\u575a\u5982\u78d0\u77f3\u30022017\u5e74\uff0c\u5176\u67094\u4e2a\u6297\u764c\u836f\u9500\u552e\u989d\u8d85\u8fc7\u91cd\u78c5\u836f\u54c1\u95e8\u69db\uff0810\u4ebf\u7f8e\u5143\u4ee5\u4e0a\uff09\uff0c\u5206\u6790\u5e08\u9884\u8ba1\uff0c\u4eca\u5e74\u4e00\u9879\u65b0\u6279\u51c6\u4e5f\u5c06\u624e\u6839\u4e8e\u8fd9\u7247\u571f\u5730\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u8fd9\u5c06\u662f\u5f3a\u751f\u7684\u4e3b\u8981\u764c\u75c7\u836f\u54c1Zytiga\uff08abiraterone\uff0c\u963f\u6bd4\u7279\u9f99\uff09\u7684\u540e\u7eed\u8005Erleada\uff08Apalutamide\uff09\u3002\u5c3d\u7ba1\u6709\u6765\u81ea\u5b89\u817e\u7279\u516c\u53f8\u548c\u8f89\u745e\u516c\u53f8Xtandi\uff08Enzalutamide\uff0c\u6069\u624e\u9c81\u80fa\uff09\u7684\u6fc0\u70c8\u7ade\u4e89\uff0c\u53bb\u5e74Zytiga\u7684\u9500\u552e\u989d\u4ecd\u8fbe25.1\u4ebf\u7f8e\u5143\u3002Erleada\u7528\u4e8e\u975e\u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c\u6cbb\u7597\u5728\u4eca\u5e742\u6708\u4efd\u63d0\u524d\u6570\u6708\u83b7\u5f97\u6279\u51c6\uff0c\u4ece\u800c\u53d6\u5f97\u4e86\u5148\u673a\u3002\u534e\u5c14\u8857\u8457\u540d\u6295\u8d44\u94f6\u884cLeerink Partners\u7684\u5206\u6790\u5e08\u9884\u8ba1\uff0cErleada\u5c06\u5b9e\u73b013\u4ebf\u7f8e\u5143\u7684\u5cf0\u503c\u9500\u552e\u989d\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u5f3a\u751f\u516c\u53f8\u4e5f\u662f\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u9886\u57df\u7684\u4e00\u652f\u91cd\u8981\u529b\u91cf\uff0c\u5176\u4e0e\u6b66\u7530\u5408\u4f5c\u7684Velcade\uff08Bortezomib\uff0c\u787c\u66ff\u4f50\u7c73\uff09\u957f\u671f\u4ee5\u6765\u4e00\u76f4\u5360\u636e\u7740\u81f3\u9ad8\u65e0\u4e0a\u7684\u5730\u4f4d\u30022017\u5e74\u5728\u7f8e\u56fd\u4ee5\u5916\u5e02\u573a\u6536\u5165\u4e3a11.1\u4ebf\u7f8e\u5143\uff0c\u7531\u5f3a\u751f\u62f1\u624b\u9500\u552e\u3002\u8be5\u516c\u53f8\u8fd8\u6709\u4e00\u4e2a\u4ea7\u54c1Darzalex\uff08Daratumumab\uff0c\u8fbe\u96f7\u6728\u5355\u6297\uff09\uff0c\u53bb\u5e74\u9500\u552e\u989d12.4\u4ebf\u7f8e\u5143\uff0c\u8d85\u8fc7\u9884\u671f\uff0c\u5b83\u53ef\u80fd\u5f15\u9886\u9886\u5bfc\u65b0\u4e00\u4ee3\u9aa8\u9ad3\u7624\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u7531\u4e8e5\u6708\u4efdFDA\u5f00\u542f\u7eff\u706f\uff0c\u5b83\u88ab\u5141\u8bb8\u4e0eVelcade\u548c\u6cfc\u5c3c\u677e\u8054\u5408\u4f7f\u7528\uff0c\u6cbb\u7597\u4e0d\u9002\u5b9c\u4f5c\u79fb\u690d\u4ee5\u524d\u672a\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u4f7f\u5f97Darzalex\u6210\u4e3a\u9996\u4e2a\u5728\u65b0\u8bca\u65ad\u60a3\u8005\u6cbb\u7597\u4e2d\u83b7\u51c6\u7684\u5355\u514b\u9686\u6297\u4f53\u3002Darzalex\u7684\u9500\u552e\u989d\u53ea\u4f1a\u7ee7\u7eed\u589e\u957f\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u5f3a\u751f\u4e0e\u827e\u4f2f\u7ef4\u5171\u4eab\u7684Imbruvica\uff08Ibrutinib\uff0c\u4f9d\u9c81\u66ff\u5c3c\uff09\uff0c\u53bb\u5e74\u83b7\u5f9718.9\u4ebf\u7f8e\u5143\u6536\u5165\uff0c\u6700\u8fd1\u7528\u4e8eWaldenstr\u00f6m\u5de8\u7403\u86cb\u767d\u8840\u75c7\u60a3\u8005\u83b7\u51c6\uff0c\u5e94\u8be5\u4f1a\u4f7f\u9500\u552e\u989d\u6301\u7eed\u4e0a\u5347\u3002\u7136\u800c\uff0c\u963f\u65af\u5229\u5eb7\u7684Calquence\uff08Acalabrutinib\uff09\u9884\u8ba1\u5c06\u6700\u7ec8\u5728\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u4e2d\u6311\u6218Imbruvica\u3002<\/span><\/p>\n<section  class=\"_135editor\" style=\"white-space: normal;border-color: currentcolor;border-style: none;border-width: 0px;box-sizing: border-box;\">\n<p style=\"margin-top: 8px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: #003472;color: #003472;\"><span class=\"autonum\" style=\"margin-right: 8px;padding: 4px 10px;background-color: #003472;color: #fefefe;display: block;float: left;line-height: 20px;\"><strong>5<\/strong><\/span><strong>\u8f89\u745e<\/strong><\/p>\n<\/section>\n<p style=\"text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u6297\u764c\u836f\u9500\u552e\u989d\uff1a2017-58.6\u4ebf\u7f8e\u5143\uff1b2024\u9884\u8ba1-140.3\u4ebf\u7f8e\u5143\uff08\u540d\u6b21\u63d0\u53471\u4f4d\uff09<br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u8f89\u745e\u516c\u53f8\u5728\u80bf\u7624\u5b66\u9886\u57df\u62e5\u6709\u5927\u91cf\u8d44\u4ea7\uff0c\u5305\u62ec\u4e00\u4e9b\u5168\u65b0\u7684\u836f\u7269\u3002\u8be5\u516c\u53f8\u7684\u95ee\u9898\u5728\u54ea\uff1f\u5728\u67d0\u4e9b\u9886\u57df\uff0c\u5b83\u7684\u65b0\u836f\u5e76\u4e0d\u51fa\u8272\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4f46Ibrance\uff08palbociclib\uff0c\u54cc\u67cf\u897f\u5229\uff09\u5e76\u975e\u5982\u6b64\u3002\u8f89\u745e\u7684\u8fd9\u4e2a\u6297\u764c\u836f\u4e4b\u738b\u662f2015\u5e74\u767b\u5802\u5165\u5ba4\u7684\u7b2c\u4e00\u4e2aCDK 4\/6\u836f\u7269\uff0c\u5e76\u4e14\u5728\u65b0\u7684\u7ade\u4e89\u5bf9\u624b\u8bfa\u534e\u7684Kisqali\uff08Ribociclib\uff09\u548c\u5229\u6765\u7684Verliio\u9762\u4e16\u4e4b\u524d\u5b83\u5df2\u7ecf\u8de8\u5165\u91cd\u78c5\u836f\u54c1\u884c\u5217\u3002\u8be5\u516c\u53f8\u7684\u4e00\u4f4d\u9ad8\u7ba1\u6700\u8fd1\u8868\u793a\uff0cIbrance\u5728\u4e16\u754c\u8303\u56f480\u591a\u4e2a\u56fd\u5bb6\u83b7\u51c6\uff0c\u81ea\u4e0a\u5e02\u4ee5\u6765\uff0c\u7ea6\u670916\u4e07\u540d\u5973\u6027\u63a5\u53d7\u4e86\u8be5\u836f\u7684\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u5bf9\u4e8e\u8f89\u745e\u6765\u8bf4\u4e0d\u5e78\u7684\u662f\uff0c\u5b83\u5728\u7ade\u4e89\u7684\u8bb8\u591a\u9886\u57df\u90fd\u4e0d\u5177\u5907\u8fd9\u79cd\u5e02\u573a\u9886\u5148\u4f18\u52bf\u3002\u4ee5PD-1 \/ PD-L1\u4e3a\u4f8b\uff0c\u5b83\u4e0e\u9ed8\u514b\u5171\u6709\u7684Bavencio\uff08Avelumab\uff09\u662f\u7ee7\u9ed8\u6c99\u4e1c\u7684Keytruda\uff0c\uff08pembrolizumab\uff09\u3001\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u7684Opdivo\u548c\u7f57\u6c0f\u7684Tecentriq\u4e4b\u540e\u7b2c4\u4e2a\u83b7\u51c6\u7684\u6b64\u7c7b\u836f\u7269\u3002\u867d\u7136\u5b83\u9996\u5148\u5728\u8f6c\u79fb\u6027Merkel\u7ec6\u80de\u764c\u6cbb\u7597\u4e2d\u83b7\u5f97\u826f\u597d\u6548\u679c\uff0c\u4f46\u5728\u80ba\u764c\u6cbb\u7597\u5b83\u8fdc\u8fdc\u843d\u540e\u4e8e\u7ade\u4e89\u5bf9\u624b\uff0c\u80ba\u764c\u662f\u514d\u75ab\u836f\u7269\u7684\u6700\u5927\u5e02\u573a\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u8f89\u745e\u7684\u80bf\u7624\u836f\u4e24\u9879\u6700\u65b0\u6279\u51c6\uff0c\u5373Vizimpro\uff08Dacomitinib\uff0c\u8fbe\u514b\u66ff\u5c3c\uff09\u548cTalzenna\uff08Talazoparib\uff0c\u4ed6\u5511\u5e15\u5c3c\uff09\uff0c\u8fd9\u79cd\u843d\u540e\u66f4\u4e3a\u660e\u663e\u3002Vizimpro\u662f\u66fe\u7ecf\u5931\u8d25\u7684\u7528\u4e8eEGFR\u7a81\u53d8\u60a3\u8005\u9776\u5411\u80ba\u764c\u836f\u7269\uff0c\u6b63\u5728\u4e0e\u7f57\u6c0f\u7684Tarceva\uff08Erlotinib\uff09\u3001\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u7684Gilotrif\uff08Afatinib\uff0c\u963f\u6cd5\u66ff\u5c3c\uff09\u548c\u963f\u65af\u5229\u5eb7\u7684Tagrisso\uff08Osimertinib\uff09\u7ade\u4e89\u3002Talzenna\u5fc5\u987b\u5728PARP\u6cbb\u7597\u9886\u57df\u53d6\u5f97\u8fdb\u5c55\uff0c\u8be5\u9886\u57df\u5df2\u7ecf\u6709\u963f\u65af\u5229\u5eb7\u548c\u9ed8\u514b\u7684Lynparza\uff08Olaparib\uff0c\u5965\u62c9\u5e15\u5c3c\uff09\uff0cClovis Oncology\u7684Rubraca\uff08Rucaparib\uff09\u548cTesaro\u7684Zejula\uff08Niraparib\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4e0d\u8fc7\uff0c\u8f89\u745e\u516c\u53f8\u8fd8\u6709\u5176\u5b83\u836f\u7269\u4f5c\u4e3a\u652f\u6491\u3002Xalkori\uff08Crizotinib\uff0c\u514b\u5511\u66ff\u5c3c\uff09\u6700\u8fd1\u5728\u4e00\u7ebfALK\u9633\u6027\u80ba\u764c\u7ade\u4e89\u836f\u54c1\u8bd5\u9a8c\u4e2d\u8868\u73b0\u7a81\u51fa\uff0c\u53bb\u5e74\u5b83\u7684\u9500\u552e\u989d\u8fbe\u5230\u4e865.94\u4ebf\u7f8e\u5143\u3002\u4e0e\u5b89\u65af\u6cf0\u6765\u5171\u6709\u7684\u524d\u5217\u817a\u764c\u836fXtandi\uff08Enzalutamide\uff0c\u6069\u624e\u9c81\u80fa\uff09\u5206\u5f975.9\u4ebf\u7f8e\u5143\u6536\u5165\uff0c\u4e24\u5bb6\u516c\u53f8\u5df2\u8ba1\u5212\u65b0\u7684\u7528\u9014\u3002\u76ee\u524d\u5b83\u4eec\u6b63\u5728\u8fdb\u884c\u6fc0\u7d20\u654f\u611f\u6027\u75be\u75c5\u7684\u4e00\u5bf9\u8bd5\u9a8c\uff0c\u4e00\u9879\u8003\u5bdfXtandi\u5bf9\u764c\u75c7\u5df2\u7ecf\u8f6c\u79fb\u7684\u60a3\u8005\u7684\u4f5c\u7528\uff0c\u53e6\u4e00\u9879\u9488\u5bf9\u764c\u75c7\u5c1a\u672a\u6269\u6563\u7684\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4e0e\u6b64\u540c\u65f6\uff0c\u4e3e\u8db3\u8f7b\u91cd\u7684\u80be\u764c\u836fSutent\uff08sunitinib\uff0c\u8212\u5c3c\u66ff\u5c3c\uff09\u4ecd\u5728\u4ea7\u751f\u91cd\u78c5\u4ea7\u54c1\u9500\u552e\u989d\uff0c\u540e\u7ee7\u8005Inlyta\uff08axitinib\uff0c\u963f\u6614\u66ff\u5c3c\uff09\u53ef\u80fd\u4f1a\u53d1\u6325\u5f97\u66f4\u597d\uff0c\u8fd9\u5f97\u5f52\u529f\u4e8e\u7528\u4e8e\u6b64\u75c7\u7684\u65b0\u578b\u514d\u75ab\u80bf\u7624\u5b66\u7ec4\u5408\u3002<\/span><\/p>\n<section  class=\"_135editor\" style=\"white-space: normal;border-color: currentcolor;border-style: none;border-width: 0px;box-sizing: border-box;\">\n<p style=\"margin-top: 8px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: #003472;color: #003472;\"><span class=\"autonum\" style=\"margin-right: 8px;padding: 4px 10px;background-color: #003472;color: #fefefe;display: block;float: left;line-height: 20px;\"><strong>6<\/strong><\/span><strong>\u963f\u65af\u5229\u5eb7<\/strong><\/p>\n<\/section>\n<p style=\"text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u6297\u764c\u836f\u9500\u552e\u989d\uff1a2017-40.2\u4ebf\u7f8e\u5143\uff1b2024\u9884\u8ba1-137.3\u4ebf\u7f8e\u5143\uff08\u540d\u6b21\u63d0\u53472\u4f4d\uff09<br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u8fd1\u5e74\u6765\uff0c\u4e5f\u8bb8\u6ca1\u6709\u54ea\u5bb6\u516c\u53f8\u6bd4AstraZeneca\u66f4\u79ef\u6781\u6295\u5165\u80bf\u7624\u5b66\u9886\u57df\uff0c\u800c\u8fd9\u80a1\u52a8\u529b\u5c06\u4f7f\u8fd9\u5bb6\u82f1\u56fd\u5236\u836f\u5546\u5728\u6392\u540d\u4e2d\u63d0\u5347\u4e24\u4f4d\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u963f\u65af\u5229\u5eb7\u662fPD-1 \/ PD-L1\u7c7b\u514d\u75ab\u80bf\u7624\u4ea7\u54c1\u7684\u53c2\u4e0e\u8005\uff0c\u5176Imfinzi\uff08Durvalumab\uff09\u80fd\u591f\u6311\u8d77\u5927\u6881\u3002\u4eca\u5e74\u65e9\u4e9b\u65f6\u5019\uff0c\u8be5\u7269\u5728\u5148\u524d\u6cbb\u7597\u8fc7\u76843\u671f\u80ba\u764c\u9886\u57df\u83b7\u5f97\u4e86\u6210\u4e3a\u91cd\u78c5\u4ea7\u54c1\u7684\u6f5c\u529b\uff0c\u8fd9\u662f\u4e00\u4e2a\u76f8\u5f53\u5927\u7684\u5e02\u573a\uff0c\u5206\u6790\u5e08\u8ba4\u4e3a\u5b83\u5c06\u5728\u672a\u6765\u51e0\u5e74\u5185\u5b9e\u73b0\u76ee\u6807\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4e0d\u8fc7\uff0cImfinzi\u80fd\u591f\u8dfb\u8eab\u963f\u65af\u5229\u5eb7\u7684\u9876\u7ea7\u4ea7\u54c1\uff0c\u505a\u51fa\u591a\u5927\u8d21\u732e\u5c1a\u6709\u5f85\u89c2\u5bdf\u3002\u5b83\u7684\u672a\u6765\u53d6\u51b3\u4e8e\u6b63\u5728\u6700\u91cd\u8981\u7684\u4e00\u7ebf\u80ba\u764c\u6cbb\u7597\u8fdb\u884c\u7684\u4e00\u9879\u8bd5\u9a8c\uff0c\u8fc4\u4eca\u4e3a\u6b62\u5c1a\u672a\u83b7\u5f97\u7ed3\u679c\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u963f\u65af\u5229\u5eb7\u5728\u80bf\u7624\u5b66\u90e8\u95e8\u8fd8\u6709\u5f88\u591a\u5de5\u4f5c\u8981\u505a\u3002\u8be5\u516c\u53f8\u62e5\u6709PARP\u6291\u5236\u5242Lynparza\uff08Lynparza\uff0c\u5965\u62c9\u5e15\u5229\uff09\uff0c\u5b83\u5728\u4eca\u5e74\u524d6\u4e2a\u6708\u4ea7\u751f\u4e862.69\u4ebf\u7f8e\u5143\u6536\u5165\uff0c\u5e76\u4e14\u5728\u4e00\u9879\u65b0\u7684\u4e73\u817a\u764c\u6cbb\u7597\u6279\u51c6\u65b9\u9762\u5904\u4e8e\u6709\u5229\u5730\u4f4d\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u8fd8\u6709Tagrisso\uff08Osimertinib\uff09\uff0c\u4e00\u79cd\u9776\u5411\u80ba\u764c\u836f\u7269\uff0c\u5176\u9500\u552e\u989d\u5728\u4eca\u5e74\u9996\u5b63\u5ea6\u589e\u957f\u4e8689\uff05\uff0c\u8fbe\u52307.6\u4ebf\u7f8e\u5143\u3002\u5b83\u53d7\u5230\u4f5c\u4e3a\u4e00\u7ebfEGFR\u7a81\u53d8\u80ba\u764c\u7684\u65b0\u9002\u5e94\u75c7\u7684\u652f\u6301\uff0c\u4eca\u5e74\u53ef\u80fd\u6210\u4e3a\u65b0\u7684\u62a4\u7406\u6807\u51c6\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u963f\u65af\u5229\u5eb7\u8fd8\u5bf9Calquence\uff08Acalabrutinib\uff09\u5bc4\u4e88\u539a\u671b\uff0c\u8be5\u836f\u5728\u53bb\u5e7410\u6708\u83b7\u51c6\uff0c\u9884\u8ba1\u5c06\u5411\u5f3a\u751f\u548c\u827e\u4f2f\u7ef4\u7684\u8840\u764c\u91cd\u91cf\u7ea7\u4ea7\u54c1Imbruvica\uff08(Ibrutinib\uff0c\u4f9d\u9c81\u66ff\u5c3c\uff09\u53d1\u8d77\u6311\u6218\u3002<\/span><\/p>\n<section  class=\"_135editor\" style=\"white-space: normal;border-color: currentcolor;border-style: none;border-width: 0px;box-sizing: border-box;\">\n<p style=\"margin-top: 8px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: #003472;color: #003472;\"><span class=\"autonum\" style=\"margin-right: 8px;padding: 4px 10px;background-color: #003472;color: #fefefe;display: block;float: left;line-height: 20px;\"><strong>7<\/strong><\/span><strong>\u9ed8\u514b<\/strong><\/p>\n<\/section>\n<p style=\"text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u6297\u764c\u836f\u9500\u552e\u989d\uff1a2017-41.1\u4ebf\u7f8e\u5143\uff1b2024\u9884\u8ba1-132.1\u4ebf\u7f8e\u5143\uff08\u540d\u6b21\u65e0\u53d8\u5316\uff09<br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u9ed8\u514b\u7684Keytruda\uff08Pembrolizumab\uff09\u73b0\u5728\u6b63\u5728\u514d\u75ab\u80bf\u7624\u5b66\u9886\u57df\u5d2d\u9732\u5934\u89d2\uff0c\u4f46EP\u8ba4\u4e3a\u8be5\u516c\u53f8\u57282024\u5e74\u5230\u6765\u65f6\u8be5\u516c\u53f8\u5728\u80bf\u7624\u836f\u9500\u552e\u4e2d\u4ecd\u5c06\u6392\u540d\u7b2c7\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u53e6\u4e00\u65b9\u9762\uff0c\u5c4a\u65f6\u8fd9\u5bb6\u5236\u836f\u5de8\u5934\u7684\u6297\u764c\u836f\u9500\u552e\u989d\u5c06\u6bd4\u53bb\u5e74\u589e\u52a090\u591a\u4ebf\u7f8e\u5143\uff0c\u5176\u4e2d\u5927\u90e8\u5206\u5c06\u6765\u81ea\u8be5\u516c\u53f8\u89c6\u4f5c\u201c\u6447\u94b1\u6811\u201d\u7684PD-1\u4ea7\u54c1\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u80ba\u764c\u662f\u65b0\u4e00\u4ee3\u6297\u764c\u836f\u4e2d\u6700\u5177\u7ade\u4e89\u529b\u7684\u9886\u57df\uff0c\u8fd9\u662f\u56e0\u4e3a\u5b83\u4ee3\u8868\u7740\u5de8\u5927\u7684\u5e02\u573a\u673a\u9047\u3002\u76ee\u524d\uff0cKeytruda\u5728\u6765\u81ea\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff0c\u963f\u65af\u5229\u5eb7\u3001\u7f57\u6c0f\u548c\u8f89\u745e-\u9ed8\u514b\u7684\u7ade\u4e89\u4e2d\u5904\u4e8e\u9886\u5148\u5730\u4f4d\uff0c\u5df2\u7ecf\u83b7\u5f97\u4e24\u9879\u6279\u51c6\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">Keytruda\u5728\u5176\u5b83\u8bb8\u591a\u764c\u75c7\u7c7b\u578b\u4e2d\u4e5f\u7559\u4e0b\u4e86\u7ed9\u4eba\u6df1\u523b\u7684\u5370\u8c61\uff0c\u5728\u5934\u9888\u764c\u3001\u5bab\u9888\u764c\u3001\u6dcb\u5df4\u7624\u7b49\u6cbb\u7597\u4e2d\u83b7\u5f97\u6279\u51c6\u3002\u5176\u83b7\u51c6\u9002\u5e94\u75c7\u67099\u9879\u4e4b\u591a\uff0c\u8fd9\u5c06\u6709\u52a9\u4e8e\u5176\u9500\u552e\u589e\u957f\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">Keytruda\u72ec\u6728\u4e0d\u6210\u6797\uff0c\u9ed8\u514b\u516c\u53f8\u6700\u8fd1\u8fbe\u6210\u4e86\u4e00\u5bf9\u534f\u8bae\uff0c\u4ee5\u83b7\u5f97\u4e24\u79cd\u6709\u5e0c\u671b\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u5e76\u5e0c\u671b\u8fd9\u79cd\u6cbb\u7597\u65b9\u6cd5\u80fd\u591f\u5927\u6709\u4f5c\u4e3a\u3002\u53bb\u5e747\u6708\uff0c\u5b83\u652f\u4ed885\u4ebf\u7f8e\u5143\u6362\u53d6\u963f\u65af\u5229\u5eb7PARP\u6291\u5236\u5242Lynparza\uff08Olaparib\uff0c\u5965\u62c9\u5e15\u5229\uff09\u7684\u534a\u62e5\u6709\u6743\uff0c\u4eca\u5e743\u6708\u4ee558\u4ebf\u7f8e\u5143\u4ee3\u4ef7\u683c\u6536\u8d2d\u4e86\u536b\u6750\u7684Lenvima\uff08Lenvatinib\uff09\u8d44\u4ea750\uff05\u80a1\u4efd\u3002<\/span><\/p>\n<section  class=\"_135editor\" style=\"white-space: normal;border-color: currentcolor;border-style: none;border-width: 0px;box-sizing: border-box;\">\n<p style=\"margin-top: 8px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: #003472;color: #003472;\"><span class=\"autonum\" style=\"margin-right: 8px;padding: 4px 10px;background-color: #003472;color: #fefefe;display: block;float: left;line-height: 20px;\"><strong>8<\/strong><\/span><strong>\u8bfa\u534e<\/strong><\/p>\n<\/section>\n<p style=\"text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u6297\u764c\u836f\u9500\u552e\u989d\uff1a2017-41.1\u4ebf\u7f8e\u5143\uff1b2024\u9884\u8ba1-132.1\u4ebf\u7f8e\u5143\uff08\u540d\u6b21\u540e\u90004\u4f4d\uff09<br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">2024\u5e74\u6392\u540d\u540e\u9000\u7684\u4ec5\u8bfa\u534e\u4e00\u5bb6\u516c\u53f8\u3002\u636eEP\u9884\u6d4b\uff0c\u5728\u672a\u67656\u5e74\u5c06\u67094\u5bb6\u540c\u884c\u8d85\u8d8a\u5b83\u7684\u5730\u4f4d\u3002\u4e4b\u524d\u60c5\u51b5\u5e76\u975e\u5982\u6b64\u3002\u56de\u99962014\u5e744\u6708\uff0c\u8bfa\u534e\u540c\u610f\u4ee5160\u4ebf\u7f8e\u5143\u83b7\u53d6\u845b\u5170\u7d20\u53f2\u514b\u7684\u764c\u75c7\u6295\u8d44\u7ec4\u5408\uff0c\u5b83\u4fbf\u5728\u764c\u75c7\u6cbb\u7597\u9886\u57df\u5360\u636e\u4e86\u4e00\u5e2d\u4e4b\u5730\uff1a\u845b\u5170\u7d20\u53f2\u514b\u7684\u9ed1\u8272\u7d20\u7624\u836f\u7269Tafinlar\uff08Dabrafenib\uff0c\u8fbe\u62c9\u83f2\u5c3c\uff09\u548cMekinist\uff08Trametinib\uff0c\u66f2\u7f8e\u66ff\u5c3c\uff09\u4ee5\u53ca\u5176\u5b83\u836f\u7269\u52a0\u4e0a\u8bfa\u534e\u516c\u53f8\u81ea\u8eab\u7684\u4ea7\u54c1Gleevec\uff08Imatinib,\u4f0a\u9a6c\u66ff\u5c3c\/\u683c\u5217\u536b\uff09\uff0cTasigna\uff08Nilotinib\uff0c\u5c3c\u6d1b\u66ff\u5c3c\/\u8fbe\u5e0c\u7eb3\uff09\uff0cAfinitor\uff08Everolimus\uff0c\u4f9d\u7ef4\u83ab\u53f8\/\u98de\u5c3c\u59a5\uff09\uff0cJakavi\uff08Ruxolitinib\uff0c\u9c81\u7d22\u66ff\u5c3c\uff09\u7b49\uff0c\u9635\u5bb9\u5f3a\u5927\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u8bfa\u534e\u516c\u53f8\u66fe\u7ecf\u8ba1\u5212\u201c\u4f18\u5316\u201dTafinlar\u548cMekinist\uff0c\u5c06\u81ea\u8eab\u5b9a\u4f4d\u4e3a\u201c\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u7684\u9886\u5bfc\u8005\u201d\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u5f53\u7136\uff0c\u8fd9\u662f\u5728\u9ed8\u514b\u7684Keytruda\uff08Pembrolizumab\uff09\u548c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u7684Opdivo\uff08Nivolumab\uff09\u51fa\u73b0\u4e4b\u524d\u3002\u8fd9\u4e24\u4e2a\u514d\u75ab\u80bf\u7624\u836f\u7269\u73b0\u5728\u90fd\u662f\u91cd\u78c5\u4ea7\u54c1\uff0c\u5728\u8fdb\u5165\u4e00\u7cfb\u5217\u5176\u5b83\u9002\u5e94\u75c7\u4e4b\u524d\u5c31\u5f00\u59cb\u5165\u4e3b\u9ed1\u8272\u7d20\u7624\u6cbb\u7597\uff0c\u5b83\u4eec\u7684\u5236\u9020\u5546\u4e00\u76f4\u52aa\u529b\u5c06\u5b83\u4eec\u5c3d\u65e9\u8fdb\u5165\u89d2\u8272\u5e76\u4f5c\u4e3a\u7ec4\u5408\u65b9\u6848\u7684\u4e00\u90e8\u5206\u8fdb\u884c\u6d4b\u8bd5\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4ece\u90a3\u65f6\u8d77\uff0cGleevec\u4e5f\u53d7\u5230\u4e86\u4eff\u5236\u836f\u7684\u51b2\u51fb\uff0c\u8be5\u836f\u5728\u8bfa\u534e\u7684\u80bf\u7624\u836f\u9500\u552e\u4e2d\u5360\u636e\u4e86\u5f88\u5927\u6bd4\u4f8b\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4e0a\u8ff0\u79cd\u79cd\u5e76\u4e0d\u610f\u5473\u8bfa\u534e\u7684\u6297\u764c\u836f\u9500\u552e\u65e5\u540e\u4e0d\u4f1a\u589e\u957f\u3002\u9700\u8981\u4e00\u63d0\u8be5\u516c\u53f8\u7684CAR-T\u7ec6\u80de\u6cbb\u7597\u5242Kymriah\uff08Tisagenlecleucel\uff09\uff0c\u5c3d\u7ba1\u65e9\u671f\u5236\u9020\u9047\u5230\u56f0\u96be\uff0c\u4f46\u9884\u8ba1\u6700\u7ec8\u4f1a\u5f15\u8d77\u4eba\u4eec\u7684\u5173\u6ce8\u3002\u7531\u4e8e\u53bb\u5e74\u4f5c\u4e3a\u9996\u9009ALK\u9633\u6027\u80ba\u764c\u6cbb\u7597\u836f\u83b7\u51c6\uff0cZykadia\uff08Ceritinib\uff0c\u8272\u745e\u66ff\u5c3c\uff09\u5e94\u8be5\u4e5f\u4f1a\u505a\u51fa\u8f83\u5927\u8d21\u732e\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u8bfa\u534e\u4e5f\u5e0c\u671b\u8ba9Kisqali\uff08Ribociclib\uff09\u7ee7\u7eed\u53d6\u5f97\u8fdb\u5c55\uff0c\u4e0e\u8f89\u745e\u516c\u53f8\u7684Ibrance\uff08Palbociclib\uff09\u548c\u5229\u6765\u7684Verzenio\uff08Abemaciclib)\uff09\u5728HR\u9633\u6027\uff0cHER2\u9634\u6027\u4e73\u817a\u764c\u6cbb\u7597\u9886\u57df\u7ade\u4e89\u3002<\/span><\/p>\n<section  class=\"_135editor\" style=\"white-space: normal;border-color: currentcolor;border-style: none;border-width: 0px;box-sizing: border-box;\">\n<p style=\"margin-top: 8px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: #003472;color: #003472;\"><span class=\"autonum\" style=\"margin-right: 8px;padding: 4px 10px;background-color: #003472;color: #fefefe;display: block;float: left;line-height: 20px;\"><strong>9<\/strong><\/span><strong>\u827e\u4f2f\u7ef4<\/strong><\/p>\n<\/section>\n<p style=\"text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u6297\u764c\u836f\u9500\u552e\u989d\uff1a2017-30.9\u4ebf\u7f8e\u5143\uff1b2024\u9884\u8ba1-84.7\u4ebf\u7f8e\u5143\uff08\u540d\u6b21\u63d0\u53471\u4f4d\uff09<br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">2015\u5e74\uff0c\u827e\u4f2f\u7ef4\u4e3a\u83b7\u5f97\u6297\u764c\u836fImbruvica\uff08Ibrutinib\uff0c\u4f9d\u9c81\u66ff\u5c3c\uff09\u652f\u4ed8\u4e8621\u4ebf\u7f8e\u5143\uff0c\u5728\u80bf\u7624\u5b66\u9886\u57df\u5f15\u8d77\u4e86\u8f70\u52a8\uff0c\u73b0\u5728\u5b83\u4e0e\u5f3a\u751f\u516c\u53f8\u5171\u6709\u8fd9\u4e2a\u4ea7\u54c1\u3002\u4ece\u90a3\u65f6\u8d77\uff0c\u5b83\u4e00\u76f4\u81f4\u529b\u4e8e\u901a\u8fc7\u5176\u5b83\u6e20\u9053\u5bfb\u627e\u5bf9\u4ed8\u764c\u75c7\u7684\u65b0\u836f\uff0c\u5e76\u4e14\u6301\u7eed\u91c7\u53d6Imbruvica\u4e0e\u65b0\u836f\u7ec4\u5408\u7684\u7b56\u7565\u6269\u5927\u5e02\u573a\u3002\u636eEP\u9884\u6d4b\u81f32024\u5e74\u827e\u4f2f\u7ef4\u7684\u6392\u540d\u5c06\u4f1a\u63d0\u5347\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 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style=\"margin-right: 8px;padding: 4px 10px;background-color: #003472;color: #fefefe;display: block;float: left;line-height: 20px;\"><strong>10<\/strong><\/span><strong>\u5b89\u65af\u6cf0\u6765<\/strong><\/p>\n<\/section>\n<p style=\"text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u6297\u764c\u836f\u9500\u552e\u989d\uff1a2017-28.5\u4ebf\u7f8e\u5143\uff1b2024\u9884\u8ba1-58.3\u4ebf\u7f8e\u5143\uff08\u540d\u6b21\u63d0\u53471\u4f4d\uff09<br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 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