{"id":65574,"date":"2018-10-30T01:00:00","date_gmt":"2018-12-07T03:51:54","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/f2bfb278a2\/"},"modified":"2018-12-07T11:51:55","modified_gmt":"2018-12-07T03:51:55","slug":"f2bfb278a2","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/65574\/","title":{"rendered":"\u80bf\u7624\u9886\u57df\u7814\u53d1\u6210\u679c\u8fdb\u5c55\u6982\u8ff0"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"_135editor\"   style=\"border: 0px none;box-sizing: border-box;\">\n<section class=\"135brush\" >\n<section class=\"_135editor\"   style=\"border: 0px none;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border: 0px none;box-sizing: border-box;\">\n<section  class=\"_135editor\" style=\"font-size: 16px;white-space: normal;font-family: \u5fae\u8f6f\u96c5\u9ed1;border: 0px none;box-sizing: border-box;\">\n<section class=\"_135editor\"     style=\"border: 0px none;box-sizing: border-box;\">\n<section class=\"135brush\"  placeholder=\"\u6df1\u8272\u8fb9\u6846\u6807\u9898\" style=\"margin-top: 10px;margin-bottom: 10px;padding: 10px;line-height: 25px;color: rgb(109, 4, 14);border-top-left-radius: 4px;border-top-right-radius: 4px;border-bottom-right-radius: 4px;border-bottom-left-radius: 4px;box-shadow: rgb(153, 153, 153) 2px 2px 4px 0px;border-left-width: 10px;border-left-style: solid;border-color: rgb(21, 59, 143);background-color: rgb(225, 227, 226);box-sizing: border-box;\">\n<p style=\"margin-top: 5px;margin-bottom: 5px;padding-right: 10px;padding-left: 10px;text-align: justify;font-size: 14px;line-height: 2em;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;text-indent: 0em;\"><span style=\"font-size: 15px;text-align: justify;\">\u4eca\u5e74\u7684\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u5e74\u4f1a\u5c55\u793a\u4e86\u4e00\u7cfb\u5217\u91cd\u8981\u6570\u636e\uff0c\u5728\u80bf\u7624\u5b66\u65b9\u9762\uff0c\u5f00\u521b\u6027\u7684\u65b0\u836f\u4e0d\u65ad\u6d8c\u73b0\uff0c\u5e76\u4e14\u5f7b\u5e95\u6539\u53d8\u764c\u75c7\u6cbb\u7597<\/span>\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"font-size: 16px;white-space: normal;font-family: \u5fae\u8f6f\u96c5\u9ed1;border: 0px none;box-sizing: border-box;\">\n<section  style=\"padding-right: 5px;display: inline-block;width: 558px;border-width: 0px 10px 1px 0px;border-style: solid;border-bottom-color: rgb(27, 58, 149);border-left-color: rgb(27, 58, 149);border-right-color: rgb(27, 58, 149);border-bottom-left-radius: 0px;border-top-right-radius: 0px;box-sizing: border-box;\">\n<section style=\"text-align: right;transform: translate3d(0px, 0px, 0px);\">\n<p class=\"135brush\" >&nbsp;\u5168\u65872517\u5b57\uff0c\u7528\u65f65\u5206\u949f<\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\"><span style=\"color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &#39;Helvetica Neue&#39;, &#39;PingFang SC&#39;, &#39;Hiragino Sans GB&#39;, &#39;Microsoft YaHei UI&#39;, &#39;Microsoft YaHei&#39;, Arial, sans-serif;font-size: 15px;letter-spacing: 0.5440000295639038px;text-align: justify;background-color: rgb(255, 255, 255);\">\u4f5c\u8005\uff1a\u8bb8\u5173\u715c\u3001\u674e\u654f\u534e<\/span><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4eca\u5e74\u7684\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u5e74\u4f1a\u5c55\u793a\u4e86\u4e00\u7cfb\u5217\u91cd\u8981\u6570\u636e\uff0c\u5728\u80bf\u7624\u5b66\u65b9\u9762\uff0c\u4ece\u672a\u50cf\u73b0\u5728\u8fd9\u6837\u5f00\u521b\u6027\u7684\u65b0\u836f\u7c7b\u5982PD-1\/L1\uff08\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d-1\u53ca\u5176\u914d\u4f53\uff09\uff0cPARP\uff08\u9776\u5411\u805aADP\u6838\u7cd6\u805a\u5408\u9176\uff09\u548cCDK\uff08\u7ec6\u80de\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u6fc0\u9176\uff094\/6\u4e0d\u65ad\u6d8c\u73b0\uff0c\u5e76\u4e14\u5f7b\u5e95\u6539\u53d8\u764c\u75c7\u6cbb\u7597\u3002\u672c\u6587\u5c06\u4f1a\u8bae\u4e00\u4e9b\u5173\u6ce8\u70b9\u4f5c\u7b80\u8981\u4ecb\u7ecd\u3002<\/span><\/p>\n<section  class=\"_135editor\" style=\"border: 0px none;\">\n<p style=\"margin-top: 8px;font-size: 16px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: rgb(0, 52, 114);color: rgb(0, 52, 114);\"><span class=\"autonum\" style=\"background-color:#003472;color:#fefefe;display:block;float:left;line-height:20px;margin-right:8px;padding:4px 10px;\"><strong>1<\/strong><\/span><span style=\"letter-spacing: normal;\"><strong style=\"text-align: justify;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);\">Tecentriq\u6cbb\u7597\u201c\u4e09\u9634\u6027\u201d\u4e73\u817a\u764c<\/strong><\/span><\/p>\n<\/section>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4f17\u6240\u5468\u77e5\u4e09\u9634\u6027\u4e73\u817a\u764c[\u96cc\u6fc0\u7d20\u53d7\u4f53\uff08HR\uff09\uff0c\u5b55\u916e\u53d7\u4f53\uff08PgR\uff09\u548c\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53-2\uff08HER2\uff09]\u4e73\u817a\u764c\uff08TNBC\uff09\u96be\u4ee5\u6cbb\u7597\uff0c\u4f46\u7f57\u6c0f\u7684\u8fd9\u4e2a\u514d\u75ab\u80bf\u7624\u836f\u5728\u4eca\u5e747\u6708\u53d6\u5f97\u4e86\u6210\u529f\u3002\u8fd9\u5bb6\u745e\u58eb\u5236\u836f\u5546\u62a5\u544a\uff0c\u5728\u65b0\u8bca\u65ad\u7684TNBC\u60a3\u8005\u4e2d\u5c06Tecentriq\uff08atezolizumab\uff09\u6dfb\u52a0\u5230\u65b0\u57fa\u7684\u5316\u7597\u836fAbraxane\uff08Protein-bound paclitaxel\uff0c\u86cb\u767d\u8d28\u7ed3\u5408\u7d2b\u6749\u9187\uff09\uff0c\u53ef\u4ee5\u51cf\u5c1120\uff05\u7684\u75be\u75c5\u6076\u5316\u6216\u6b7b\u4ea1\u98ce\u9669\u3002\u8be5\u7ec4\u5408\u4f7f\u764c\u75c7\u8fdb\u5c55\u5ef6\u8fdf\u4e2d\u4f4d\u6570\u4e3a7.2\u4e2a\u6708\uff0c\u800c\u5355\u72ec\u5316\u7597\u4e3a5.5\u4e2a\u6708\u3002\u5728\u80bf\u7624\u68c0\u6d4b\u751f\u7269\u6807\u5fd7\u7269PD-L1\u4e3a\u9633\u6027\u7684\u60a3\u8005\u7ec4\u4e2d\uff0c\u8fd9\u4e9b\u6570\u636e\u751a\u81f3\u66f4\u4f73\u3002\u5c06\u98ce\u9669\u964d\u4f4e\u4e8638\uff05\uff0c\u4f7f\u764c\u75c7\u6076\u5316\u5ef6\u8fdf\u4e867.5\u4e2a\u6708\uff0c\u800c\u5bf9\u7167\u7ec4\u5219\u4e3a5\u4e2a\u6708\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">TNBC\u662f\u4e00\u79cd\u4fb5\u88ad\u6027\u80bf\u7624\u7c7b\u578b\uff0c\u8fc7\u53bb\u4e00\u76f4\u5bf9\u5b83\u675f\u624b\u65e0\u7b56\uff0c\u90e8\u5206\u539f\u56e0\u662f\u5b83\u7f3a\u4e4f\u6fc0\u7d20\u53d7\u4f53\u6216HER2\u7b49\u9776\u70b9\uff0c\u7f3a\u4e4f\u6807\u5fd7\u7269\u3002\u73b0\u5728\u6709\u4e00\u4e2a\u65b0\u7684PD-L1\u6807\u8bb0\uff0c\u7f57\u6c0f\u516c\u53f8\u5e0c\u671bTecentriq\u80fd\u591f\u6cbb\u7597PD-L1\u9633\u6027\u8f6c\u79fb\u6027TNBC\u60a3\u8005\uff0c\u771f\u6b63\u4e3a\u4ed6\u4eec\u5e26\u6765\u4e34\u5e8a\u76ca\u5904\u3002\u8fd9\u4e9b\u6570\u636e\u53ef\u80fd\u4f7f\u5176\u6210\u4e3a\u540c\u7c7b\u4e2d\u7b2c\u4e00\u4e2a\u83b7\u51c6\u6cbb\u7597\u8fd9\u79cd\u75be\u75c5\u7684\u836f\u7269\u3002\u8fd9\u5c06\u662fPD-1\/PD-L1\u7c7b\u6297\u764c\u836f\u4e2d\u9996\u4e2a\u8fbe\u5230\u8fd9\u4e00\u76ee\u6807\u8005\u3002<\/span><\/p>\n<section class=\"_135editor\"   style=\"border: 0px none;box-sizing: border-box;\">\n<section class=\"135brush\" >\n<section class=\"_135editor\"   style=\"border: 0px none;box-sizing: border-box;\">\n<section class=\"135brush\" >\n<section class=\"_135editor\"   style=\"border: 0px none;box-sizing: border-box;\">\n<section  class=\"_135editor\" style=\"white-space: normal;border: 0px none;\">\n<p style=\"margin-top: 8px;font-size: 16px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: rgb(0, 52, 114);color: rgb(0, 52, 114);\"><span class=\"autonum\" style=\"margin-right: 8px;padding: 4px 10px;background-color: rgb(0, 52, 114);color: rgb(254, 254, 254);display: block;float: left;line-height: 20px;\"><strong>2<\/strong><\/span><span style=\"letter-spacing: normal;\"><strong style=\"background-color: rgb(255, 255, 255);\"><strong style=\"font-size: 16px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);\">alpelisib\u6cbb\u7597HR\u9633\u6027\/HER2\u9634\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c<\/strong><\/strong><\/span><\/p>\n<\/section>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4eca\u5e748\u6708\uff0c\u8bfa\u534e\u516c\u53f8\u5ba3\u5e03\u5176\u4e00\u79cd\u540d\u4e3aalpelisib\u7684\u9009\u62e9\u6027PI3K\u03b1\u6291\u5236\u5242\u7c7b\u5b9e\u9a8c\u6027\u4e73\u817a\u764c\u836f\u7269SOLAR-1\u7814\u7a76\u83b7\u5f97\u6210\u529f\u3002\u8fd9\u4e00\u6d88\u606f\u5f15\u4eba\u6ce8\u76ee\uff0c\u56e0\u4e3a\u6700\u8fd1\u4e0e\u8bfa\u534e\u516c\u53f8\u5019\u9009\u836f\u7269\u7c7b\u4f3c\u7684\u9879\u76ee\u5e76\u4e0d\u987a\u5229\u3002<\/span><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4e4b\u524d\u6cbb\u7597\u8fc7\u7684HR\u9633\u6027\/HER2\u9634\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u7edd\u7ecf\u540e\u5987\u5973\uff0c\u63a5\u53d7alpelisib\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\uff08fulvestrant\uff09\u8054\u5408\u6cbb\u7597\u4e0e\u5355\u72ec\u7684\u6c1f\u7ef4\u53f8\u7fa4\u76f8\u6bd4\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u6539\u55845.3\u4e2a\u6708\u3002\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\u76f8\u6bd4\uff0c\u76f8\u5bf9\u98ce\u9669\u964d\u4f4e35\uff05\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u5b89\u5168\u6027\u6570\u636e\u663e\u793a\u8be5\u7ec4\u5408\u53ef\u5bfc\u81f4\u9ad8\u8840\u7cd6\u3001\u8179\u6cfb\u548c\u6076\u5fc3\u7684\u663e\u8457\u53d1\u751f\uff0c\u8bfa\u534e\u516c\u53f8\u6307\u51fa\uff1a\u5927\u591a\u6570\u4e0d\u826f\u4e8b\u4ef6\u53ef\u901a\u8fc7\u5242\u91cf\u8c03\u6574\u6216\u533b\u7597\u7ba1\u7406\u6765\u63a7\u5236\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">Alpelisib\u9776\u5411\u9488\u5bf9\u4e00\u79cd\u79f0\u4e3aPI3KA\u7684\u7279\u5f02\u6027\u7a81\u53d8\uff0c\u636e\u4f30\u8ba1\uff0c\u5728\u7528\u82b3\u9999\u9176\u6291\u5236\u5242\u6cbb\u7597\u540e\u764c\u75c7\u8fdb\u5c55\u7684\u60a3\u8005\u4e2d\u7ea6\u5360\u636e40\uff05\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u201c\u6211\u4eec\u5df2\u7ecf\u6709\u4e86HER2\u9776\u5411\u836f\u7269\uff0c\u4f46\u662f\u76f4\u5230\u73b0\u5728\uff0c\u80bf\u7624\u57fa\u56e0\u7ec4\u5b66\u7684\u4f7f\u7528\u8fd8\u6ca1\u6709\u771f\u6b63\u8fdb\u5165\u4e73\u817a\u764c\u7684\u5b9e\u9645\u62a4\u7406\uff0c\u4e0d\u50cf\u9ed1\u8272\u7d20\u7624\u6216\u80ba\u764c\uff0c\u201d\u62a5\u544a\u7b2c\u4e00\u4f5c\u8005\uff0c\u6cd5\u56fd\u7ef4\u52d2\u745e\u592b\u7814\u7a76\u6240\u53e4\u65af\u5854\u592b\u9c81\u897f\u533b\u5b66\u9662\u80bf\u7624\u5185\u79d1\u6559\u6388Fabrice Andr\u00e9\u5728ESMO\u8bf4\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4eca\u5e74\u590f\u5929PI3K\u6291\u5236\u5242taselisib\u56e0\u4e3a\u4ee4\u4eba\u5931\u671b\u7684\u7ed3\u679c\uff1a\u663e\u793a\u98ce\u9669\u964d\u4f4e30\uff05\u548c\u5b89\u5168\u6027\u8f83\u5dee\u4e4b\u540e\uff0c\u7f57\u6c0f\u516c\u53f8\u505c\u6b62\u5176\u5f00\u53d1\u3002\u5728\u7814\u7a76\u8fc7\u7a0b\u4e2d\uff0c\u63a5\u53d7taselisib\u7684\u60a3\u8005\u7ea6\u67091\/5\u7ec8\u6b62\u6cbb\u7597\uff0c\u800c\u8bfa\u534e\u7684alpelisib\u961f\u5217\u7814\u7a76\u4e2d\u53ea\u67095\uff05\u60a3\u8005\u9000\u51fa\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u4f1a\u4e0a\uff0c\u8bfa\u534e\u8fd8\u62a5\u544a\u4e86\u540d\u4e3acapmatinib\u7684\u5b9e\u9a8c\u6027\u4e00\u9879\u80ba\u764c\u6cbb\u7597\u7814\u7a76\u7684\u9633\u6027\u7ed3\u679c\u3002\u6570\u636e\u663e\u793a\u8be5\u836f\u5bf9\u672a\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684MET\u5916\u663e\u5b5014\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u603b\u5e94\u7b54\u7387\u4e3a72\uff05\u3002<\/span><\/p>\n<section  class=\"_135editor\" style=\"white-space: normal;border: 0px none;\">\n<p style=\"margin-top: 8px;font-size: 16px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: rgb(0, 52, 114);color: rgb(0, 52, 114);\"><span class=\"autonum\" style=\"margin-right: 8px;padding: 4px 10px;background-color: rgb(0, 52, 114);color: rgb(254, 254, 254);display: block;float: left;line-height: 20px;\"><strong>3<\/strong><\/span><span style=\"letter-spacing: normal;\"><strong style=\"background-color: rgb(255, 255, 255);\"><strong style=\"font-size: 16px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);\">Bavencio &amp; Inlyta\u8054\u5408\u6cbb\u7597\u80be\u764c<\/strong><\/strong><\/span><\/p>\n<\/section>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u9ed8\u6c99\u4e1c\u7684Keytruda\uff08Pembrolizumab\uff09\u57282014\u5e749\u6708\u9996\u6b21\u83b7\u51c6\u4e4b\u540e\uff0c\u9002\u5e94\u75c7\u4e0d\u65ad\u62d3\u5c55\uff08\u9ed1\u8272\u7d20\u7624\uff0c\u8f6c\u79fb\u6027\uff0c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u5934\u9888\u764c\uff0c\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u5c3f\u8def\u4e0a\u76ae\u764c\uff0c\u80c3\u764c\uff0c\u5bab\u9888\u764c\uff09\u3002\u5728\u4eca\u5e74ASCO\u5e74\u4f1a\u4e0a\u8fde\u7eed\u516c\u5e03\u8be5\u516c\u53f8\u53c8\u516c\u5e03\u4e86\u591a\u9879\u5173\u4e8eKeytruda\u7684\u79ef\u6781\u6210\u679c\u3002\u5982\u679c\u9ed8\u514b\u7684\u83b7\u80dc\uff0c\u80be\u764c\u5e02\u573a\u5c06\u53d8\u5f97\u8d8a\u53d1\u62e5\u6324\u3002<\/span><br  \/><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u800c\u9ed8\u514b\u4e0e\u8f89\u745e\u4e5f\u79ef\u6781\u8fdb\u519b\u80be\u7ec6\u80de\u764c\u4e00\u7ebf\u836f\u7269\u5e02\u573a\uff0c\u8fd9\u4e24\u5bb6\u516c\u53f8\u62a5\u544a\u4e86\u9ed8\u514b\u7684\u514d\u75ab\u80bf\u7624\u836f\u7269Bavencio\uff08avelumab\uff09\u4e0e\u8f89\u745e\u7684\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242Inlyta\uff08axitinib\uff09\u7ec4\u5408\u7597\u6cd5\u7684JAVELIN Renal 101\u7814\u7a76\u7ed3\u679c\uff0c\u663e\u793a\u4e0e\u8f89\u745e\u7684\u8212\u5c3c\u66ff\u5c3c\u76f8\u6bd4\uff0c\u7ec4\u5408\u7597\u6cd5\u4f7f PD-L1\u9633\u6027\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u589e\u52a039%\u3002\u800c10\u5e74\u6765\u8212\u5c3c\u66ff\u5c3c\u4e00\u76f4\u662f\u80be\u7ec6\u80de\u4e00\u7ebf\u6cbb\u7597\u7684\u53c2\u8003\u6807\u51c6\u3002\u4e0d\u7ba1\u60a3\u8005\u80bf\u7624\u662f\u5426\u8868\u8fbePD-L1\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5747\u6709\u663e\u8457\u83b7\u76ca\uff0c\u4e0e\u8212\u5c3c\u66ff\u5c3c\u6cbb\u7597\u7ec4\u60a3\u8005\u76f8\u6bd4\uff0c\u60a3\u8005\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u589e\u52a031%\uff0c\u5e76\u4e14\u5728\u6240\u6709\u60a3\u8005\u4eba\u7fa4\uff08\u6709\u5229\u7684\u3001\u4e2d\u95f4\u7684\u3001\u9884\u540e\u8f83\u5dee\u7684\uff09\u4e2d\u8be5\u7ec4\u5408\u7597\u6cd5\u7684\u6548\u679c\u662f\u4e00\u81f4\u7684\u3002\u5206\u6790\u5e08\u4eec\u8ba4\u4e3a\uff0c\u8fd9\u79cd\u7ec4\u5408\u53ef\u80fd\u4f1a\u6210\u4e3a\u80be\u7ec6\u80de\u764c\u6cbb\u7597\u7684\u65b0\u6807\u51c6\u3002<\/span><\/p>\n<section  class=\"_135editor\" style=\"white-space: normal;border: 0px none;\">\n<p style=\"margin-top: 8px;font-size: 16px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: rgb(0, 52, 114);color: rgb(0, 52, 114);\"><span class=\"autonum\" style=\"margin-right: 8px;padding: 4px 10px;background-color: rgb(0, 52, 114);color: rgb(254, 254, 254);display: block;float: left;line-height: 20px;\"><strong>4<\/strong><\/span><span style=\"letter-spacing: normal;\"><strong style=\"background-color: rgb(255, 255, 255);\"><strong style=\"font-size: 16px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);\">\u5375\u5de2\u764c\u7ef4\u6301\u6cbb\u7597\u836fLynparza<\/strong><\/strong><\/span><\/p>\n<\/section>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u963f\u65af\u5229\u5eb7\u548c\u5408\u4f5c\u4f19\u4f34\u9ed8\u6c99\u4e1c\u5728\u4eca\u5e746\u6708\u83b7\u5f97\u4e86\u4e00\u9879\u5173\u952e\u6027\u8bd5\u9a8c\u7684\u80dc\u5229\uff0c\u8bd5\u9a8c\u663e\u793aLynparza\uff08olaparib\uff0c\u5965\u62c9\u5e15\u5c3c\uff09\u53ef\u4ee5\u963b\u6b62\u65b0\u8bca\u65ad\u7684BRCA\u7a81\u53d8\u5375\u5de2\u764c\u60a3\u8005\u6076\u5316\u3002\u6839\u636e\u7b2c3\u9636\u6bb5\u7814\u7a76\u7684\u7ed3\u679c\uff0cLynparza\u88ab\u8bc1\u660e\u53ef\u4ee5\u964d\u4f4e\u5375\u5de2\u764c\u60a3\u8005\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u98ce\u9669\u3002\u8fd9\u4e9b\u7ed3\u679c\u5bf9\u4e24\u5bb6\u516c\u53f8\u975e\u5e38\u6709\u5229\uff0c\u5e76\u4e14\u5f88\u53ef\u80fd\u5c06\u8fd9\u79cd\u836f\u7269\u4f5c\u4e3a\u8fd9\u4e9b\u5375\u5de2\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\u836f\u7269\u6279\u51c6\u3002<\/span><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u6b64\u6b21ESMO\u4e0a\u963f\u65af\u5229\u5eb7\u62a5\u544a\u4e86\u4f7f\u7528Lynparza\u6cbb\u7597\u665a\u671fBRCA\u7a81\u53d8\u5375\u5de2\u764c\u60a3\u8005\u7684III\u671f\u7814\u7a76\u83b7\u5f97\u7684\u9633\u6027\u7ed3\u679c\uff0c\u4f7f\u7528Lynparza\u6cbb\u7597\u7684\u60a3\u8005\u80fd\u591f\u5c06\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e70\uff05\u3002Lynparza\u4e5f\u6b63\u5728\u8fdb\u884c\u4e00\u9879\u540d\u4e3aPAOLA-1\u7684III\u671f\u7814\u7a76\uff0c\u4e0eAvastin\u8054\u5408\u7528\u4e8e\u65b0\u8bca\u65ad\u7684\u5375\u5de2\u764c\u60a3\u8005\uff0c\u9884\u8ba12019\u5e74\u4e0b\u534a\u5e74\u5f97\u5230\u6570\u636e\u3002\u8be5\u836f\u5f88\u53ef\u80fd\u4f5c\u4e3a\u8fd9\u4e9b\u5375\u5de2\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\u836f\u7269\u83b7\u5f97\u6279\u51c6\u3002\u636e\u9884\u6d4b\uff0c\u52302023\u5e74\uff0cLynparza\u7684\u6536\u5165\u5c06\u53ef\u9ad8\u8fbe20\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n<section  class=\"_135editor\" style=\"white-space: normal;border: 0px none;\">\n<p style=\"margin-top: 8px;font-size: 16px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: rgb(0, 52, 114);color: rgb(0, 52, 114);\"><span class=\"autonum\" style=\"margin-right: 8px;padding: 4px 10px;background-color: rgb(0, 52, 114);color: rgb(254, 254, 254);display: block;float: left;line-height: 20px;\"><strong>5<\/strong><\/span><span style=\"letter-spacing: normal;\"><strong style=\"background-color: rgb(255, 255, 255);\"><strong style=\"font-size: 16px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);\">Keytruda\u7528\u4e8e\u4e00\u7ebf\u5934\u9888\u90e8\u764c\u6cbb\u7597<\/strong><\/strong><\/span><\/p>\n<\/section>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u9ed8\u6c99\u4e1c\u7684Keytruda\uff08pembrolizumab\uff0c\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\u7528\u4e8e\u521d\u6cbb\u7684\u5934\u9888\u90e8\u764c\u6709\u6761\u4ef6\u6279\u51c6\u66fe\u7ecf\u9677\u4e8e\u56f0\u5883\uff0c\u53bb\u5e747\u6708\u672a\u80fd\u8bc1\u660e\u5b83\u53ef\u4ee5\u5ef6\u957f\u60a3\u8005\u751f\u547d\uff0c\u4e0d\u8fc7\uff0c\u73b0\u5728\u8be5\u516c\u53f8\u5df2\u7ecf\u638c\u63e1\u4e86\u83b7\u51c6\u6240\u9700\u6570\u636e\u3002<\/span><br  \/><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">21\u65e5\uff0c\u9ed8\u6c99\u4e1c\u5206\u5e03\u62a5\u544a\u79f0\uff1aKeytruda\u5728\u4e00\u9879III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u4f5c\u4e3a\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5934\u9888\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u7597\u6cd5\u663e\u8457\u5ef6\u957f\u4e86\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff0c\u8fbe\u5230\u4e86\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5b83\u662f\u9996\u4e2a\u5728\u6b64\u75c7\u4e00\u7ebf\u6cbb\u7597\u4e2d\u663e\u793a\u51fa\u4f18\u5f02\u603b\u751f\u5b58\u671f\u7684\u6297PD-1\u7597\u6cd5\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u5934\u9888\u764c\u662f\u4e00\u7c7b\u53d1\u751f\u4e8e\u53e3\u9f3b\u5589\u90e8\u7684\u764c\u75c7\uff0c\u5176\u4e2d\u5927\u90e8\u5206\u662f\u9cde\u72b6\u7ec6\u80de\u764c\u3002\u636e\u4f30\u8ba1\uff0c2012\u5e74\u4e16\u754c\u8303\u56f4\u7ea6\u6709\u8fd168.6\u4e07\u65b0\u53d1\u75c5\u4f8b\uff0c\u670937.6\u4e07\u4eba\u56e0\u6b64\u4e27\u751f\u3002\u5728\u7f8e\u56fd\uff0c2017\u5e74\u7ea6\u67096.3\u4e07\u65b0\u53d1\u75c5\u4f8b\u3002\u8fd9\u4e9b\u60a3\u8005\u6781\u9700\u83b7\u5f97\u6709\u6548\u7684\u6cbb\u7597\u3002<\/span><\/p>\n<section  class=\"_135editor\" style=\"white-space: normal;border: 0px none;\">\n<p style=\"margin-top: 8px;font-size: 16px;line-height: 28px;min-height: 32px;border-bottom-width: 2px;border-bottom-style: solid;text-align: justify;border-bottom-color: rgb(0, 52, 114);color: rgb(0, 52, 114);\"><span class=\"autonum\" style=\"margin-right: 8px;padding: 4px 10px;background-color: rgb(0, 52, 114);color: rgb(254, 254, 254);display: block;float: left;line-height: 20px;\"><strong>6<\/strong><\/span><span style=\"letter-spacing: normal;\"><strong style=\"background-color: rgb(255, 255, 255);\"><strong style=\"font-size: 16px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);\">\u4fe1\u53f7\u5206\u5b50STING\u6fc0\u6d3b\u5242MK-1454<\/strong><\/strong><\/span><\/p>\n<\/section>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u9ed8\u6c99\u4e1c\u4ee5Keytruda\u5728\u514d\u75ab\u80bf\u7624\u5b66\u9886\u57df\u53d6\u5f97\u4e86\u9886\u5148\u5730\u4f4d\uff0c\u8be5\u516c\u53f8\u63a8\u51fa\u4e86\u4e00\u9879\u5e7f\u6cdb\u7684\u4e34\u5e8a\u8ba1\u5212\uff0c\u6d4b\u8bd5\u5404\u79cd\u514d\u75ab\u6cbb\u7597\u836f\u7269\u7684\u7ec4\u5408\u3002\u6b63\u5728\u7814\u7a76\u6709\u7ea620\u79cd\u5b9e\u9a8c\u6027\u836f\u7269\uff0c\u8fd9\u4e9b\u836f\u7269\u65e8\u5728\u901a\u8fc7\u8c03\u8282\u673a\u4f53\u7684\u514d\u75ab\u9632\u5fa1\u673a\u5236\u6765\u5bf9\u4ed8\u80bf\u7624\u3002<\/span><br  \/><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">\u8be5\u516c\u53f8\u6b64\u524d\u770b\u597d\u5176\u4e2d\u4e00\u79cd\u836f\u7269\uff0c\u4ee3\u53f7\u4e3aMK-1454\uff0c\u7279\u522b\u6709\u610f\u4e49\u3002\u4f46\u662f\uff0c\u5728ESMO\u62a5\u544a\u7684\u65e9\u671f\u7ed3\u679c\u5bf9\u5b83\u53ef\u80fd\u7684\u4f5c\u7528\u4ea7\u751f\u4e86\u7591\u95ee\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0%;\"><span style=\"font-size: 15px;\">MK-1454\u65e8\u5728\u6fc0\u6d3b\u4e00\u79cd\u88ab\u79f0\u4e3aSTING\u7684\u4fe1\u53f7\u5206\u5b50\uff0c\u523a\u6fc0\u4ea7\u751f\u53ef\u5438\u5f15T\u7ec6\u80de\u7684\u708e\u75c7\u86cb\u767d\u3002\u4ece\u7406\u8bba\u4e0a\u8bb2\uff0c\u8fd9\u53ef\u80fd\u6709\u52a9\u4e8e\u589e\u52a0\u5bf9\u764c\u7ec6\u80de\u7684\u514d\u75ab\u4ecb\u5bfc\u53cd\u5e94\uff0c\u7279\u522b\u662f\u5982\u679c\u4e0e\u50cfKeytruda\u90a3\u6837\u6709\u52a9\u4e8e\u53d1\u6325\u514d\u75ab\u653b\u51fb\u7684\u514d\u75ab\u836f\u7269\u914d\u5bf9\u65f6\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0px;\"><span style=\"font-size: 15px;\">\u9ed8\u6c99\u4e1c\u4ecb\u7ecd\u7684MK-1454\u7684I\u671f\uff08\u665a\u671f\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\/\u6dcb\u5df4\u8089\u7624\uff09\u7814\u7a76\u7ed3\u679c\uff0c\u5e76\u6ca1\u6709\u6fc0\u8d77\u4eba\u4eec\u591a\u5927\u5174\u8da3\u3002\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\uff0c\u88ab\u8bc4\u4f30\u768420\u540d\u60a3\u8005\u4f7f\u7528MK-1454\u6cbb\u7597\u65e0\u5b8c\u5168\u6216\u90e8\u5206\u5e94\u7b54\u300225\u540d\u4e2d\u67096\u540d\u63a5\u53d7Keytruda\u52a0MK-1454\u6cbb\u7597\u7684\u60a3\u8005\u7ecf\u5386\u4e86\u90e8\u5206\u5e94\u7b54\uff0c\u5728\u4f5c\u6570\u636e\u5206\u6790\u65f6\u8bd5\u9a8c\u4ecd\u5728\u8fdb\u884c\u4e2d\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;font-size: 14px;line-height: 2em;padding-right: 10px;padding-left: 10px;margin: 20px 0px;\"><span style=\"font-size: 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