{"id":66196,"date":"2018-12-03T01:00:00","date_gmt":"2018-12-07T03:59:37","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/920845f260\/"},"modified":"2018-12-07T11:59:39","modified_gmt":"2018-12-07T03:59:39","slug":"920845f260","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/66196\/","title":{"rendered":"\u3010\u57f9\u4f18\u3011\u73af\u7403\u533b\u836f\u7b80\u8baf|\u7b2c83\u671f"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"\"   >\n<section>\n<section class=\"\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"margin: 10px auto;display: flex;justify-content: center;align-items: center;\">\n<section style=\"width: 330px;\"><img class=\"\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/6-1544155178.gif\" alt=\"\u3010\u57f9\u4f18\u3011\u73af\u7403\u533b\u836f\u7b80\u8baf|\u7b2c83\u671f\" title=\"\u3010\u57f9\u4f18\u3011\u73af\u7403\u533b\u836f\u7b80\u8baf|\u7b2c83\u671f\"><\/section>\n<\/section>\n<\/section>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"width: 100%;\" >\n<section style=\"display: flex;justify-content: space-between;align-items:flex-end;margin-bottom:-13px;\">\n<section style=\"margin-left: -1px;\">\n<section style=\"display:inline-block;padding-right:10px;background:#fefefe;color:#ffde03;font-weight: bold;font-size: 14px;\">\u2715<\/section>\n<\/section>\n<section style=\"margin-left: -1px;\">\n<section style=\"display:inline-block;padding-left:10px;background:#fefefe;color:#ffde03;font-weight: bold;font-size: 14px;\">\u2715<\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-left: 5px;\">\n<section   style=\"border-width: 2px;border-style: solid;border-color: rgb(214, 240, 252);\">\n<section>\n<section class=\"135brush\" style=\"text-align:justify;font-size: 14px;padding:1em;line-height: 1.75em;color:#333;letter-spacing: 1.5px;\">\n<p style=\"white-space: normal;text-align: justify;letter-spacing: 0.5px;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><strong><span style=\"font-variant-numeric: normal;font-variant-east-asian: normal;color: rgb(51, 51, 51);font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;line-height: 32px;text-align: justify;widows: 1;background-color: rgb(255, 255, 255);\">\u2460&nbsp;<\/span><\/strong><\/span><span style=\"font-size: 14px;font-variant-numeric: normal;font-variant-east-asian: normal;color: rgb(51, 51, 51);font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.544px;line-height: 32px;text-align: justify;widows: 1;background-color: rgb(255, 255, 255);\">\u8fd1\u65e5\uff0c<strong>\u8f89\u745e<\/strong>\u5ba3\u5e03\u4e0e<strong>AbbVie<\/strong>\u5c31<strong>\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f<\/strong>\u5168\u7403\u8303\u56f4\u7684\u4e13\u5229\u8bc9\u8bbc\u8fbe\u6210\u548c\u89e3\u3002\u6839\u636e\u534f\u8bae\uff0c\u5728\u6b27\u6d32\u5e02\u573a\uff0c\u8f89\u745e\u7684\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u83b7\u5f97EMA\u6279\u51c6\u540e\u5c31\u53ef\u4e0a\u5e02\u9500\u552e\u3002\u4f46\u662f\u5728\u7f8e\u56fd\u5e02\u573a\uff0c\u8f89\u745e\u9700\u89812023\u5e7411\u670820\u65e5\u4ee5\u540e\u65b9\u53ef\u4e0a\u5e02\u9500\u552e\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 2em;\"><span style=\"font-size: 16px;\"><strong>\u2461&nbsp;<\/strong><\/span><span style=\"font-size: 14px;\">11\u670829\u65e5\uff0c<strong>\u4e50\u666e\u533b\u7597<\/strong>\u516c\u544a\u79f0\uff0c\u5168\u8d44\u5b50\u516c\u53f8\u4e50\u666e\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6838\u51c6\u7b7e\u53d1\u7684\u5173\u4e8e<strong>\u201c\u786b\u9178\u6c22\u6c2f\u5421\u683c\u96f7\u7247\u201d<\/strong>\u7684\u300a\u836f\u54c1\u8865\u5145\u7533\u8bf7\u6279\u4ef6\u300b\uff0c\u8be5\u836f\u54c175mg\u548c25mg\u89c4\u683c\u5747\u901a\u8fc7\u4e86\u4eff\u5236\u836f\u8d28\u91cf\u548c\u7597\u6548\u4e00\u81f4\u6027\u8bc4\u4ef7\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;letter-spacing: 0.5px;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><strong>\u2462&nbsp;<\/strong><\/span><span style=\"font-size: 14px;color: rgb(51, 51, 51);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;text-align: justify;widows: 1;background-color: rgb(255, 255, 255);\">\u65e5\u524d\uff0c\u4e2d\u56fd\u533b\u836f\u521b\u65b0\u7684\u4e24\u5bb6\u4ee3\u8868\u6027\u516c\u53f8<strong>\u4fe1\u8fbe\u751f\u7269<\/strong>\u4e0e<strong>\u548c\u8bb0\u9ec4\u57d4\u533b\u836f<\/strong>\u8fbe\u6210\u5168\u7403\u5408\u4f5c\u3002\u4e24\u5bb6\u516c\u53f8\u5c06\u8054\u5408\u5176\u9886\u5148\u836f\u7269<strong>PD-1\u5355\u6297\u4fe1\u8fea\u5229\u5355\u6297<\/strong>\u4e0e<strong>VEGFR\u6291\u5236\u5242\u544b\u55b9\u66ff\u5c3c<\/strong>\u6cbb\u7597\u5b9e\u4f53\u7624\u60a3\u8005\uff0c\u5e76\u8bc4\u4f30\u8054\u5408\u7597\u6cd5\u7684\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;letter-spacing: 0.5px;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><strong>\u2463&nbsp;<\/strong><\/span><span style=\"font-size: 14px;color: rgb(51, 51, 51);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;text-align: justify;widows: 1;background-color: rgb(255, 255, 255);\">\u4e00\u81f4\u6027\u8bc4\u4ef7\u6301\u7eed\u8fdb\u884c\uff0c\u6839\u636e\u4e0a\u5e02\u836f\u4f01\u516c\u544a\u53d1\u73b0\uff0c11\u6708\u4efd\u670912\u4e2a\u54c1\u89c4\u7684\u836f\u54c1\uff0c\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 1.75em;letter-spacing: 0.5px;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;letter-spacing: 0.5px;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><strong>\u2464&nbsp;<\/strong><\/span><span style=\"font-size: 14px;color: rgb(51, 51, 51);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;text-align: justify;widows: 1;background-color: rgb(255, 255, 255);\">\u6765\u81ea\u65af\u514b\u5229\u666e\u65af\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u514b\u670d\u6b64\u524d<strong>HIV\u75ab\u82d7<\/strong>\u5f00\u53d1\u7684\u6280\u672f\u969c\u788d\u5f00\u53d1\u51fa\u4e86\u4e00\u79cd\u65b0\u578b\u7684HIV\u5019\u9009\u75ab\u82d7\uff0c\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\u8fd9\u79cd\u65b0\u578b\u75ab\u82d7\u80fd\u523a\u6fc0\u52a8\u7269\u673a\u4f53\u4ea7\u751f\u4e00\u79cd\u5f3a\u5927\u7684\u6297HIV\u6297\u4f53\u53cd\u5e94\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;letter-spacing: 0.5px;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><strong>\u2465&nbsp;<\/strong><\/span><strong><span style=\"font-size: 14px;color: rgb(51, 51, 51);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;text-align: justify;widows: 1;background-color: rgb(255, 255, 255);\">\u52c3\u6797\u683c\u6bb7\u683c\u7ff0<\/span><\/strong><span style=\"font-size: 14px;color: rgb(51, 51, 51);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;text-align: justify;widows: 1;background-color: rgb(255, 255, 255);\">\u8fd1\u65e5\u8868\u793a\uff0c\u5c06\u628a\u751f\u7269\u4eff\u5236\u836f\u5f00\u53d1\u4e0e\u5408\u4f5c\u6d3b\u52a8\u7684\u91cd\u70b9\u653e\u5728\u7f8e\u56fd\u5e02\u573a\uff0c\u5e76\u5c06\u505c\u6b62\u5728\u5168\u7403\u5176\u4ed6\u5730\u533a\u7684\u751f\u7269\u4eff\u5236\u836f\u9879\u76ee\u3002\u516c\u53f8\u53d1\u8a00\u4ebaSusan Holz\u8868\u793a\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5728\u7f8e\u56fd\u7684\u9996\u8981\u4efb\u52a1\u662f\u63a8\u51fa<strong>Cyltezo<\/strong>\u3002\u8be5\u836f\u662f\u827e\u4f2f\u7ef4\u91cd\u78c5\u836f\u4fee\u7f8e\u4e50\u7684\u751f\u7269\u4eff\u5236\u836f\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;letter-spacing: 0.5px;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><strong>\u2466&nbsp;<\/strong><\/span><strong><span style=\"font-size: 14px;color: rgb(51, 51, 51);font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;text-align: justify;widows: 1;background-color: rgb(255, 255, 255);\">\u4fe1\u7acb\u6cf0<\/span><\/strong><span style=\"font-size: 14px;color: rgb(51, 51, 51);font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;text-align: justify;widows: 1;background-color: rgb(255, 255, 255);\">\u53d1\u5e03\u516c\u544a\u79f0\u4e3a\u4e30\u5bcc\u516c\u53f8\u5728\u6297\u80bf\u7624\u9886\u57df\u7684\u521b\u65b0\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u62df\u4e0e\u7f8e\u56fdVIRACTA THERAPEUTICS, INC.\u7b7e\u8ba2\u534f\u8bae\uff0c\u83b7\u5f97<strong>VIRACTA<\/strong> \u62e5\u6709\u7684\u201c<strong>nanatinostat\u201d<\/strong>\u76f8\u5173\u77e5\u8bc6\u4ea7\u6743\u3001\u6280\u672f\u4fe1\u606f\uff0c\u5728\u4e2d\u56fd\u5927\u9646\u5730\u533a\u7684\u72ec\u5bb6\u8bb8\u53ef\u4f7f\u7528\u6743\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 1.75em;letter-spacing: 0.5px;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;letter-spacing: 0.5px;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><strong>\u2467&nbsp;<\/strong><\/span><span style=\"font-size: 14px;color: rgb(51, 51, 51);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;text-align: justify;widows: 1;background-color: rgb(255, 255, 255);\">\u6765\u81ea\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u7684\u7814\u7a76\u8005\u53d1\u73b0\u4e86\u4e00\u79cd\u8ba9\u80ba\u764c\u4ea7\u751f\u83b7\u5f97\u6027\u8010\u836f\u7684\u673a\u5236\uff0c\u5e76\u636e\u6b64\u8bbe\u8ba1\u51fa\u4e86\u65b0\u7684\u7ec4\u5408\u7597\u6cd5\u3002\u8fd9\u79cd\u7597\u6cd5\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u5c55\u73b0\u51fa\u4e86\u826f\u597d\u7684\u6297\u764c\u6548\u679c\uff0c\u6709\u671b\u7ed9\u665a\u671f\u80ba\u764c\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 1.75em;letter-spacing: 0.5px;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;letter-spacing: 0.5px;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><strong>\u2468<\/strong><\/span><span style=\"font-size: 14px;\"><strong>&nbsp;<\/strong><span style=\"font-size: 14px;color: rgb(51, 51, 51);font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;text-align: justify;widows: 1;background-color: rgb(255, 255, 255);\">\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u897f\u73ed\u7259\u3001\u6cd5\u56fd\u3001\u5fb7\u56fd\u548c\u65b0\u52a0\u5761\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u67d0\u4e9b\u7ec6\u80de\u5728\u67d0\u4e9b\u6761\u4ef6\u4e0b\u80fd\u591f\u8868\u73b0\u51fa\u8d85\u5f39\u6027\u3002\u5728\u8fd9\u9879\u65b0\u7684\u7814\u7a76\u4e2d\u7814\u7a76\u4eba\u5458\u5728\u51e0\u4e2a\u5c0f\u65f6\u5185\u7814\u7a76\u4e86\u5355\u5c42\u4e0a\u76ae\u7ec6\u80de\u3002\u4e0d\u5e78\u7684\u662f\u5728\u4ed4\u7ec6\u7814\u7a76\u7ec6\u80de\u4e2d\u7684\u8d85\u5f39\u6027\u7279\u6027\u540e\uff0c\u4ed6\u4eec\u4ecd\u7136\u65e0\u6cd5\u89e3\u91ca\u5b83\u662f\u5982\u4f55\u53d1\u751f\u7684\u3002<\/span><\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;letter-spacing: 0.5px;line-height: 1.75em;\"><span style=\"font-size: 16px;\"><strong>\u2469<\/strong><\/span><span style=\"font-size: 14px;\"><strong>&nbsp;<\/strong><strong><span style=\"font-size: 14px;color: rgb(51, 51, 51);font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;text-align: justify;widows: 1;background-color: rgb(255, 255, 255);\">\u62dc\u8033<\/span><\/strong><span style=\"font-size: 14px;color: rgb(51, 51, 51);font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;text-align: justify;widows: 1;background-color: rgb(255, 255, 255);\">\u548c<strong>Loxo Oncology<\/strong>\u7684\u65b0\u578b\u9776\u5411\u6297\u764c\u836f<strong>Vitrakvi<\/strong>\u5728\u7f8e\u56fd\u76d1\u7ba1\u65b9\u9762\u8fce\u6765\u91cd\u5927\u559c\u8baf\u3002\u7f8e\u56fdFDA\u6279\u51c6\u5176\u6cbb\u7597\u643a\u5e26NTRK\u57fa\u56e0\u878d\u5408\u7684\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u3002\u6b64\u6b21\u6279\u51c6\uff0c\u4f7fVitrakvi\u6210\u4e3a\u6709\u53f2\u4ee5\u6765\u7b2c\u4e00\u4e2aTRK\u6291\u5236\u5242\uff0c\u540c\u65f6\u4e5f\u662f\u7b2c\u4e00\u4e2a\u4e0e\u80bf\u7624\u7c7b\u578b\u65e0\u5173\u7684\u201c\u5e7f\u8c31\u201d\u6297\u764c\u836f\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: flex;justify-content: space-between;align-items:flex-end;margin-top:-13px;\">\n<section style=\"margin-left: -1px;\">\n<section style=\"display:inline-block;padding-right:10px;background:#fefefe;color:#ffde03;font-weight: bold;font-size: 14px;\">\u2715<\/section>\n<\/section>\n<section style=\"margin-left: 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