{"id":66628,"date":"2018-10-30T01:00:00","date_gmt":"2018-12-07T04:03:40","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/a535e86da1\/"},"modified":"2018-12-07T12:03:43","modified_gmt":"2018-12-07T04:03:43","slug":"a535e86da1","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/66628\/","title":{"rendered":"\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u4f30\u7b97\u63a2\u8ba8\u2014\u2014\u57f9\u4f18BE\u7cfb\u521726"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 1px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;border-width: 2px 1px;border-style: none none dashed;border-color: rgb(44, 90, 160);border-radius: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"_135editor\"     style=\"text-align: center;white-space: normal;border-width: 0px;border-style: none;border-color: initial;\" title=\"\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u4f30\u7b97\u63a2\u8ba8\u2014\u2014\u57f9\u4f18BE\u7cfb\u521726\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/9-1544155421.gif\" alt=\"\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u4f30\u7b97\u63a2\u8ba8\u2014\u2014\u57f9\u4f18BE\u7cfb\u521726\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/6-1544155421.jpg\" alt=\"\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u4f30\u7b97\u63a2\u8ba8\u2014\u2014\u57f9\u4f18BE\u7cfb\u521726\" title=\"\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u4f30\u7b97\u63a2\u8ba8\u2014\u2014\u57f9\u4f18BE\u7cfb\u521726\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;text-align: left;\">\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;vertical-align: top;letter-spacing: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;text-align: justify;font-size: 15px;line-height: 1.8;color: rgb(62, 62, 62);word-wrap: break-word !important;\">\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\uff3b\u6458\u8981\uff3d\u968f\u7740\u6211\u56fd\u4eff\u5236\u836f\u8d28\u91cf\u4e0e\u7597\u6548\u4e00\u81f4\u6027\u8bc4\u4ef7\u7684\u5168\u9762\u5f00\u5c55\uff0c\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u4f5c\u4e3a\u4e00\u81f4\u6027\u8bc4\u4ef7\u7684\u91cd\u70b9\u5185\u5bb9\u5c06\u8fce\u6765\u9ad8\u5cf0\uff0c\u5bf9\u4e8e\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u5982\u4f55\u786e\u5b9a\u5408\u9002\u7684\u6837\u672c\u91cf(\u5373\u53d7\u8bd5\u8005\u7684\u6570\u91cf)\u65e2\u662f\u5173\u952e\u53c8\u662f\u96be\u70b9\u3002\u672c\u6587\u7efc\u8ff0\u4e86\u56fd\u5185\u5916\u5bf9\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u6837\u672c\u91cf\u7684\u6cd5\u89c4\u8981\u6c42\uff0c\u63a2\u8ba8\u4e86\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u7684\u5f71\u54cd\u56e0\u7d20\u3001\u4f30\u7b97\u65b9\u6cd5\u3001\u9884\u8bd5\u9a8c\u7684\u4f5c\u7528\u7b49\u95ee\u9898\uff0c\u4ee5\u671f\u80fd\u591f\u5bf9\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u6837\u672c\u91cf\u7684\u786e\u5b9a\u63d0\u4f9b\u5efa\u8bae\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\uff3b\u5173\u952e\u8bcd\uff3d\u4e00\u81f4\u6027\u8bc4\u4ef7;\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027;\u836f\u52a8\u5b66;\u6837\u672c\u91cf;\u4eff\u5236\u836f<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 1px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;border-width: 2px 1px;border-style: none none dashed;border-color: rgb(44, 90, 160);border-radius: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: left;line-height: 1;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 0px;display: inline-block;border-top: 0.6em solid rgb(255, 255, 255);border-left: 0.6em solid rgb(255, 255, 255);word-wrap: break-word !important;border-bottom: 0.6em solid transparent !important;border-right: 0.6em solid transparent !important;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;vertical-align: top;letter-spacing: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;text-align: justify;font-size: 15px;line-height: 1.8;color: rgb(62, 62, 62);word-wrap: break-word !important;\">\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u4e3a\u63d0\u5347\u6211\u56fd\u5236\u836f\u884c\u4e1a\u6574\u4f53\u6c34\u5e73\uff0c\u4fdd\u969c\u836f\u54c1\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u4fc3\u8fdb\u533b\u836f\u4ea7\u4e1a\u5347\u7ea7\u548c\u7ed3\u6784\u8c03\u6574\uff0c\u589e\u5f3a\u56fd\u9645\u7ade\u4e89\u80fd\u529b\uff0c2016\u5e742\u6708\u56fd\u52a1\u9662\u5370\u53d1\u300a\u201c\u5341\u4e09\u4e94\u201d\u56fd\u5bb6\u836f\u54c1\u5b89\u5168\u89c4\u5212\u300b\uff3b1\uff3d\uff0c\u63d0\u51fa\u8981\u8fdb\u4e00\u6b65\u63d0\u9ad8\u836f\u54c1\u8d28\u91cf\uff0c\u6279\u51c6\u4e0a\u5e02\u7684\u4eff\u5236\u836f\u8981\u4e0e\u539f\u7814\u836f\u8d28\u91cf\u548c\u7597\u6548\u4e00\u81f4\u30022016\u5e743\u67085\u65e5\u56fd\u529e\u53d1\u30142016\u30158\u53f7\u6587\u4ef6\u300a\u5173\u4e8e\u5f00\u5c55\u4eff\u5236\u836f\u8d28\u91cf\u548c\u7597\u6548\u4e00\u81f4\u6027\u8bc4\u4ef7\u7684\u610f\u89c1\u300b\uff3b2\uff3d(\u4ee5\u4e0b\u7b80\u79f0\u201c\u300a\u610f\u89c1\u300b\u201d)\uff0c\u300a\u610f\u89c1\u300b\u8981\u6c42\uff0c\u5316\u5b66\u836f\u54c1\u65b0\u6ce8\u518c\u5206\u7c7b\u5b9e\u65bd\u524d\u6279\u51c6\u4e0a\u5e02\u7684\u4eff\u5236\u836f\uff0c\u51e1\u672a\u6309\u7167\u4e0e\u539f\u7814\u836f\u54c1\u8d28\u91cf\u548c\u7597\u6548\u4e00\u81f4\u539f\u5219\u5ba1\u6279\u7684\uff0c\u5747\u987b\u5f00\u5c55\u4e00\u81f4\u6027\u8bc4\u4ef7\u3002\u56fd\u5bb6\u57fa\u672c\u836f\u7269\u76ee\u5f55(2012\u5e74\u7248)\u4e2d2007\u5e7410\u67081\u65e5\u524d\u6279\u51c6\u4e0a\u5e02\u7684\u5316\u5b66\u836f\u54c1\u4eff\u5236\u836f\u53e3\u670d\u56fa\u4f53\u5236\u5242\uff0c\u5e94\u57282018\u5e74\u5e95\u524d\u5b8c\u6210\u4e00\u81f4\u6027\u8bc4\u4ef7\uff0c\u5176\u4ed6\u4eff\u5236\u836f\u5728\u9996\u5bb6\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u540e3\u5e74\u5185\u4e0d\u901a\u8fc7\u8bc4\u4ef7\u7684\uff0c\u6ce8\u9500\u6587\u53f7\u3002\u56fd\u52a1\u9662\u548c\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40(CFDA)\u9ad8\u5ea6\u91cd\u89c6\u4e00\u81f4\u6027\u8bc4\u4ef7\uff0c\u4e3a\u63a8\u8fdb\u4e00\u81f4\u6027\u8bc4\u4ef7\u51fa\u53f0\u4e86\u4e00\u7cfb\u5217\u653f\u7b56\u6027\u6587\u4ef6\u548c\u591a\u4e2a\u6307\u5bfc\u539f\u5219\u3002\u5bf9\u4e8e\u4eff\u5236\u836f\u4e00\u81f4\u6027\u8bc4\u4ef7\uff0c\u4e3b\u8981\u5305\u62ec\u8d28\u91cf\u4e00\u81f4\u548c\u7597\u6548\u4e00\u81f4\uff0c\u8d28\u91cf\u4e00\u81f4\u6027\u662f\u6307\u836f\u5b66\u4e00\u81f4\u6027\uff0c\u5305\u62ec\u5173\u952e\u8d28\u91cf\u53c2\u6570(CQAs)\u7684\u4e00\u81f4\u548c\u8d28\u91cf\u6807\u51c6\u7684\u76f8\u5f53;\u5bf9\u4e8e\u7597\u6548\u4e00\u81f4\u7684\u8bc4\u4ef7\u65b9\u6cd5\u539f\u5219\u4e0a\u5e94\u8be5\u901a\u8fc7\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c(BE)\u8bc4\u4ef7\uff0c\u4e3a\u4fc3\u8fdb\u548c\u89c4\u8303\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\uff0c2016\u5e743\u670828\u65e5CFDA\u53d1\u5e03\u4e86\u300a\u4ee5\u836f\u52a8\u5b66\u53c2\u6570\u4e3a\u7ec8\u70b9\u8bc4\u4ef7\u6307\u6807\u7684\u5316\u5b66\u836f\u7269\u4eff\u5236\u836f\u4eba\u4f53\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\uff3b3\uff3d\uff0c2017\u5e742\u670817\u65e5\u548c28\u65e5CFDA\u5206\u522b\u5728\u91cd\u5e86\u548c\u5317\u4eac\u5f00\u5c55\u4eff\u5236\u836f\u8d28\u91cf\u548c\u7597\u6548\u4e00\u81f4\u6027\u8bc4\u4ef7\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u57f9\u8bad\uff0c\u7531\u6b64\u53ef\u89c1BE\u662f\u4e00\u81f4\u6027\u8bc4\u4ef7\u7684\u5173\u952e\u548c\u6838\u5fc3\u5185\u5bb9\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u5728\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u4e2d\u6837\u672c\u91cf\u7684\u4f30\u7b97\u6781\u5176\u5173\u952e\uff0c\u540c\u65f6\u4e5f\u662f\u96be\u70b9\uff0c\u5982\u679c\u7eb3\u5165\u7684\u53d7\u8bd5\u8005\u4f8b\u6570\u4e0d\u8db3\uff0c\u53ef\u80fd\u65e0\u6cd5\u5f97\u5230\u786e\u5b9a\u7684\u7ed3\u8bba(\u7edf\u8ba1\u5b66\u4e0a\u8ba4\u4e3a\u628a\u63e1\u5ea6\u4e0d\u591f);\u5982\u679c\u7eb3\u5165\u8fc7\u591a\u7684\u53d7\u8bd5\u8005\uff0c\u4e0d\u4ec5\u589e\u52a0\u4e86\u8bd5\u9a8c\u7684\u8d22\u529b\u3001\u4eba\u529b\u3001\u65f6\u95f4\u6210\u672c\uff0c\u800c\u4e14\u8fd8\u5b58\u5728\u4f26\u7406\u5b66\u95ee\u9898\uff0c\u56e0\u4e3a\u751f\u7269\u7b49\u6548\u8bd5\u9a8c\u591a\u4e3a\u5065\u5eb7\u53d7\u8bd5\u8005\uff0c\u4e00\u822c\u4e0d\u80fd\u76f4\u63a5\u4ece\u751f\u7269\u7b49\u6548\u8bd5\u9a8c\u4e2d\u53d7\u76ca\uff0c\u8fc7\u591a\u7684\u53d7\u8bd5\u8005\u66b4\u9732\u4e8e\u8bd5\u9a8c\u836f\u7269\/\u53c2\u6bd4\u5236\u5242\uff0c\u589e\u52a0\u4e86\u5b89\u5168\u98ce\u9669\u3002\u56e0\u6b64\uff0c\u5bf9\u4e8e\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\uff0c\u5982\u4f55\u786e\u5b9a\u5408\u9002\u6570\u91cf\u7684\u53d7\u8bd5\u8005\u6781\u4e3a\u5173\u952e\uff0c\u7531\u4e8e\u5927\u591a\u6570\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u63a8\u8350\u4f7f\u7528\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027(refer-ence-scaled average bioequivalence\uff0c\uff32SABE)\u65b9\u6cd5\uff0c\u672c\u6587\u53c2\u8003\u76f8\u5173\u6587\u732e\u8d44\u6599\uff0c\u5bf9\u4eff\u5236\u836f\u4eba\u4f53\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u7684\u76f8\u5173\u95ee\u9898\u8fdb\u884c\u63a2\u8ba8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 1px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 4px 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;vertical-align: top;background-color: rgb(44, 90, 160);word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: middle;color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">1 \u6837\u672c\u91cf\u7684\u56fd\u5185\u5916\u6cd5\u89c4\u8981\u6c42<\/strong><\/p>\n<\/section>\n<section style=\"margin-right: 3px;margin-left: 5px;max-width: 100%;box-sizing: border-box;width: 0px;border-left: 8px solid rgb(255, 255, 255);border-top: 5px solid transparent;border-bottom: 5px solid transparent;display: inline-block;vertical-align: middle;word-wrap: break-word !important;\"><\/section>\n<section style=\"margin-right: -9px;max-width: 100%;box-sizing: border-box;width: 0px;border-left: 8px solid rgb(255, 255, 255);border-top: 4px solid transparent;border-bottom: 4px solid transparent;display: inline-block;vertical-align: middle;transform: rotate(0deg);word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;width: 0px;border-left: 10px solid rgb(255, 255, 255);border-top: 6px solid transparent;border-bottom: 6px solid transparent;display: inline-block;vertical-align: middle;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 1px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;border-width: 2px 1px;border-style: none none dashed;border-color: rgb(44, 90, 160);border-radius: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: left;line-height: 1;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 0px;display: inline-block;border-top: 0.6em solid rgb(255, 255, 255);border-left: 0.6em solid rgb(255, 255, 255);word-wrap: break-word !important;border-bottom: 0.6em solid transparent !important;border-right: 0.6em solid transparent !important;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;vertical-align: top;letter-spacing: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;text-align: justify;font-size: 15px;line-height: 1.8;color: rgb(62, 62, 62);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u6211\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c402005\u5e74\u9881\u5e03\u7684\u300a\u5316\u5b66\u836f\u7269\u5236\u5242\u4eba\u4f53\u751f\u7269\u5229\u7528\u5ea6\u548c\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\uff3b4\uff3d\u4e2d\u8981\u6c42:\u201c\u53d7\u8bd5\u8005\u4f8b\u6570\u5e94\u5f53\u7b26\u5408\u7edf\u8ba1\u5b66\u8981\u6c42\uff0c\u5bf9\u4e8e\u76ee\u524d\u7684\u7edf\u8ba1\u65b9\u6cd5\uff0c18\uff5e24\u4f8b\u53ef\u6ee1\u8db3\u5927\u591a\u6570\u836f\u7269\u5bf9\u6837\u672c\u91cf\u7684\u8981\u6c42\uff0c\u4f46\u5bf9\u67d0\u4e9b\u53d8\u5f02\u6027\u5927\u7684\u836f\u7269\u53ef\u80fd\u9700\u8981\u9002\u5f53\u589e\u52a0\u4f8b\u6570\u201d\u30022015\u7248\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u836f\u5178\u300b\u3001\u300a\u836f\u7269\u5236\u5242\u751f\u7269\u5229\u7528\u5ea6\u548c\u751f\u7269\u7b49\u6548\u6027\u6307\u5bfc\u539f\u5219\u300b(\u8349\u6848)\uff3b5\uff3d\u6307\u51fa:\u201c\u5728\u4e00\u9879\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u4e2d\uff0c\u53ef\u8bc4\u4ef7\u7684\u53d7\u8bd5\u8005\u6570\u76ee\u4e0d\u5e94\u5c11\u4e8e18\u540d\u201d\u3002CFDA 2016\u5e74\u300a\u4ee5\u836f\u52a8\u5b66\u53c2\u6570\u4e3a\u7ec8\u70b9\u8bc4\u4ef7\u6307\u6807\u7684\u5316\u5b66\u836f\u7269\u4eff\u5236\u836f\u4eba\u4f53\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\u6307\u51fa\u5165\u9009\u53d7\u8bd5\u8005\u7684\u4f8b\u6570\u5e94\u4f7f\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u5177\u6709\u8db3\u591f\u7684\u7edf\u8ba1\u5b66\u6548\u529b\u3002\u7f8e\u56fd2003\u5e74\u5728\u201cGuidance for industry\uff0cbioavail-ability andbioequivalence studies for orally adminis-tered drug products-general considerations\u201d\u4e2d\u5efa\u8bae:\u53d7\u8bd5\u8005\u7684\u603b\u6570\u5e94\u63d0\u4f9b\u8db3\u591f\u7684\u628a\u63e1\u5ea6\u83b7\u5f97\u751f\u7269\u7b49\u6548\u7684\u7ed3\u8bba\uff3b6\uff3d\u3002\u6b27\u76df2010\u5e74\u5728\u201cGuideline on the investigation ofbioequivalence\u201d\u8981\u6c42:\u7eb3\u5165\u53d7\u8bd5\u8005\u4f8b\u6570\u5e94\u57fa\u4e8e\u5408\u9002\u7684\u6837\u672c\u91cf\u8ba1\u7b97\uff0c\u53ef\u8bc4\u4ef7\u7684\u53d7\u8bd5\u8005\u4f8b\u6570\u4e0d\u5c11\u4e8e12\u4f8b\uff3b7\uff3d\u3002\u65e5\u672c2012\u5e74\u5728\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u7684\u6307\u5bfc\u539f\u5219\u4e2d\u6307\u51fa:\u5e94\u7eb3\u5165\u8db3\u591f\u53d7\u8bd5\u8005\u8fdb\u884c\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7;\u5982\u53d7\u8bd5\u8005\u4f8b\u6570\u4e0d\u8db3\u800c\u4e0d\u80fd\u83b7\u5f97\u751f\u7269\u7b49\u6548\u7684\u7ed3\u8bba\uff0c\u53ef\u8ffd\u52a0\u53d7\u8bd5\u8005\uff0c\u8ffd\u52a0\u53d7\u8bd5\u8005\u7684\u4f8b\u6570\u4e0d\u5e94\u5c11\u4e8e\u539f\u8bd5\u9a8c\u4f8b\u6570\u7684\u4e00\u534a\uff3b8\uff3d\u3002\u4ece\u4ee5\u4e0a\u4f8b\u4e3e\u7684\u56fd\u5185\u5916\u6cd5\u89c4\u5bf9\u4e8e\u6837\u672c\u91cf\u7684\u63cf\u8ff0\u53ef\u4ee5\u770b\u51fa\uff0c\u5c3d\u7ba1\u5bf9\u6700\u4f4e\u6837\u672c\u91cf\u7684\u8981\u6c42\u4e0d\u5c3d\u76f8\u540c\uff0c\u4f46\u5747\u5f3a\u8c03\u4e86\u6837\u672c\u91cf\u5e94\u7b26\u5408\u7edf\u8ba1\u5b66\u8981\u6c42\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 1px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 4px 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;vertical-align: top;background-color: rgb(44, 90, 160);word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: middle;color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">2 \u5f71\u54cd\u6837\u672c\u91cf\u7684\u56e0\u7d20<\/strong><\/p>\n<\/section>\n<section style=\"margin-right: 3px;margin-left: 5px;max-width: 100%;box-sizing: border-box;width: 0px;border-left: 8px solid rgb(255, 255, 255);border-top: 5px solid transparent;border-bottom: 5px solid transparent;display: inline-block;vertical-align: middle;word-wrap: break-word !important;\"><\/section>\n<section style=\"margin-right: -9px;max-width: 100%;box-sizing: border-box;width: 0px;border-left: 8px solid rgb(255, 255, 255);border-top: 4px solid transparent;border-bottom: 4px solid transparent;display: inline-block;vertical-align: middle;transform: rotate(0deg);word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;width: 0px;border-left: 10px solid rgb(255, 255, 255);border-top: 6px solid transparent;border-bottom: 6px solid transparent;display: inline-block;vertical-align: middle;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 1px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;border-width: 2px 1px;border-style: none none dashed;border-color: rgb(44, 90, 160);border-radius: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: left;line-height: 1;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 0px;display: inline-block;border-top: 0.6em solid rgb(255, 255, 255);border-left: 0.6em solid rgb(255, 255, 255);word-wrap: break-word !important;border-bottom: 0.6em solid transparent !important;border-right: 0.6em solid transparent !important;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;vertical-align: top;letter-spacing: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;text-align: justify;font-size: 15px;line-height: 1.8;color: rgb(62, 62, 62);word-wrap: break-word !important;\">\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000<strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;word-wrap: break-word !important;\">2\uff0e1\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u7c7b\u578b&nbsp;<\/span><\/strong><span class=\"Apple-converted-space\">&nbsp;<\/span>\u8bd5\u9a8c\u8bbe\u8ba1\u662f\u786e\u5b9a\u6837\u672c\u91cf\u7684\u524d\u63d0\uff0c\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u4e00\u822c\u91c7\u7528\u4ea4\u53c9\u8bbe\u8ba1\uff0c\u9664\u975e\u6709\u786e\u5b9e\u7684\u79d1\u5b66\u4f9d\u636e\u8868\u660e\u5e73\u884c\u8bbe\u8ba1(\u5982\u957f\u534a\u8870\u671f\u836f\u7269\u53ef\u4ee5\u91c7\u7528\u5e73\u884c\u8bbe\u8ba1)\u6216\u5176\u4ed6\u8bbe\u8ba1\u66f4\u4e3a\u5408\u9002\u3002\u4ea4\u53c9\u8bbe\u8ba1\u5206\u4e3a2\u5236\u52422\u5468\u671f\u4ea4\u53c9\u8bbe\u8ba1\u30012\u5236\u52423\u5468\u671f\u4ea4\u53c9\u8bbe\u8ba1\u548c2\u5236\u52424\u5468\u671f\u4ea4\u53c9\u8bbe\u8ba1\u3002<\/p>\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000<span style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">2\uff0e2\u751f\u7269\u7b49\u6548\u7684\u5224\u5b9a\u6807\u51c6<\/strong><\/span>&nbsp; \u76ee\u524d\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6b27\u76df\u7b49\u4e3b\u8981\u56fd\u5bb6\u548c\u5730\u533a\uff0c\u751f\u7269\u7b49\u6548\u63a5\u53d7\u6807\u51c6:\u53d7\u8bd5\u5236\u5242\u4e0e\u53c2\u6bd4\u5236\u5242\u7684AUC0\uff5et\uff0cAUC0\uff5e\u221e\uff0cCmax\u7684\u51e0\u4f55\u5747\u6570\u6bd4\u503c(geometric mean ratio\uff0cGM\uff32)\u768490%\u7f6e\u4fe1\u533a\u95f4(90%CI)\u572880\uff0e00%\uff5e125\uff0e00%\u3002\u5bf9\u4e8e\u7a84\u6cbb\u7597\u7a97\u836f\u7269\uff0c\u5e94\u6839\u636e\u836f\u7269\u7684\u7279\u6027\u9002\u5f53\u7f29\u5c0f90%CI\u8303\u56f4\uff0c\u53ef\u53d690.00%\uff5e111.11%\uff3b6\uff3d\u3002\u5bf9\u4e8e\u9ad8\u53d8\u5f02\u836f\u54c1AUC\u548c\/\u6216Cmax\uff0c\u53ef\u653e\u5bbd\u5224\u65ad\u6807\u51c6\uff0c\u4f46\u8981\u6709\u5145\u8db3\u7406\u7531\uff0c\u5e76\u5728\u8bd5\u9a8c\u65b9\u6848\u4e2d\u4e8b\u5148\u89c4\u5b9a\uff3b6\uff0d7\uff3d\u3002<\/p>\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000<span style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">2\uff0e3\u663e\u8457\u6027\u6c34\u5e73\u53ca\u628a\u63e1\u5ea6<\/strong><\/span>&nbsp; \u663e\u8457\u6027\u6c34\u5e73\u5373\u03b1\u503c\u7684\u5927\u5c0f\uff0c\u901a\u5e38\u53d60\uff0e05\u3002\u628a\u63e1\u5ea6\u4e5f\u79f0\u68c0\u9a8c\u6548\u80fd\uff0c\u4e00\u822c\u4e0d\u5c0f\u4e8e80%(1-\u03b2)\uff0c\u03b1\u4ee3\u8868\u53d1\u751f\u7b2c\u2160\u7c7b\u9519\u8bef\u6982\u7387\uff0c\u7b2c\u2160\u7c7b\u9519\u8bef\u662f\u5c06\u4e0d\u5177\u6709\u751f\u7269\u7b49\u6548\u6027\u7684\u5236\u5242\u9519\u8bef\u5730\u5224\u65ad\u4e3a\u5177\u6709\u751f\u7269\u7b49\u6548\u6027\u7684\u5236\u5242\uff0c\u4e5f\u79f0\u4e3a\u60a3\u8005\u98ce\u9669\u3002\u03b2\u4ee3\u8868\u53d1\u751f\u7b2c\u2161\u7c7b\u9519\u8bef\u7684\u6982\u7387\uff0c\u901a\u5e38\u226420%\uff0c\u7b2c\u2161\u7c7b\u9519\u8bef\u662f\u5c06\u5177\u6709\u751f\u7269\u7b49\u6548\u6027\u7684\u5236\u5242\u9519\u8bef\u5730\u5224\u65ad\u4e3a\u4e0d\u5177\u6709\u751f\u7269\u7b49\u6548\u6027\u7684\u5236\u5242\uff0c\u4e5f\u79f0\u4e3a\u751f\u4ea7\u5546\u98ce\u9669\u3002<\/p>\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000<span style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">2\uff0e4\u53d8\u5f02\u7cfb\u6570&nbsp;<\/strong><\/span><span class=\"Apple-converted-space\">&nbsp;<\/span>\u5728\u7ecf\u5178\u76842\u00d72\u4ea4\u53c9\u8bbe\u8ba1\u7684\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u4e2d\uff0c\u7ecf\u81ea\u7136\u5bf9\u6570\u8f6c\u6362\u7684AUC\u548cCmax\u8fdb\u884c4\u56e0\u7d20\u65b9\u5dee\u5206\u6790(4\u56e0\u7d20\u5305\u62ec\u836f\u7269\u5242\u578b\u3001\u7ed9\u836f\u5468\u671f\u3001\u7ed9\u836f\u987a\u5e8f\u548c\u5d4c\u5957\u5728\u7ed9\u836f\u987a\u5e8f\u5185\u7684\u53d7\u8bd5\u8005\u4e2a\u4f53\u56e0\u7d20)\uff0c\u5f97\u5230\u6b8b\u5dee(mean square error\uff0cMSE)\uff0c\u4e2a\u4f53\u5185\u53d8\u5f02\u7cfb\u6570(intra-subject CV\uff0cintra CV)intra CV=(exp(MSE)-1)^0\uff0e5\uff3b9\uff3d;\u5728\u5e73\u884c\u8bbe\u8ba1\u7684\u751f\u7269\u7b49\u6548\u6027Inter-subject CV=(exp(Var(subj(seq)))^0\uff0e5\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;text-indent: 2em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">2\uff0e5\u5dee\u522b&nbsp;<\/strong><\/span><span class=\"Apple-converted-space\">&nbsp;<\/span>\u5dee\u522b\u901a\u5e38\u4ee5\u03b8\u8868\u793a\uff0c\u03b8=\u03bcT\uff0d\u03bc\uff32\uff0c\u03bcT\u548c\u03bc\uff32\u5206\u522b\u4e3a\u53d7\u8bd5\u5236\u5242\u4e0e\u53c2\u6bd4\u5236\u5242\u53c2\u6570\u7684\u603b\u4f53\u5747\u503c\u3002\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u4e2d\uff0c\u03b8\u662f\u6307\u53d7\u8bd5\u5236\u5242\u4e0e\u53c2\u6bd4\u5236\u5242\u836f\u52a8\u5b66\u53c2\u6570\u7684\u51e0\u4f55\u5747\u6570\u7684\u6bd4\u503c\uff0c\u5373\u03b8=\u03bcT\/\u03bc\uff32\u4ee5GM\uff32\u8868\u793a\uff0c\u5bf9\u4e8e\u666e\u901a\u836f\u7269\uff0cGM\uff32\u4e00\u822c\u53d60\uff0e95(\u62161\uff0e05)\uff0c\u5dee\u5f02\u8f83\u5927\u65f6\u53ef\u4ee5\u53d6 0\uff0e 9( \u6216 1\uff0e 1) \u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 1px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 4px 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;vertical-align: top;background-color: rgb(44, 90, 160);word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: middle;color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">3 \u9884 BE \u8bd5\u9a8c\u7684\u4f5c\u7528<\/strong><\/p>\n<\/section>\n<section style=\"margin-right: 3px;margin-left: 5px;max-width: 100%;box-sizing: border-box;width: 0px;border-left: 8px solid rgb(255, 255, 255);border-top: 5px solid transparent;border-bottom: 5px solid transparent;display: inline-block;vertical-align: middle;word-wrap: break-word !important;\"><\/section>\n<section style=\"margin-right: -9px;max-width: 100%;box-sizing: border-box;width: 0px;border-left: 8px solid rgb(255, 255, 255);border-top: 4px solid transparent;border-bottom: 4px solid transparent;display: inline-block;vertical-align: middle;transform: rotate(0deg);word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;width: 0px;border-left: 10px solid rgb(255, 255, 255);border-top: 6px solid transparent;border-bottom: 6px solid transparent;display: inline-block;vertical-align: middle;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 1px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;border-width: 2px 1px;border-style: none none dashed;border-color: rgb(44, 90, 160);border-radius: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: left;line-height: 1;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 0px;display: inline-block;border-top: 0.6em solid rgb(255, 255, 255);border-left: 0.6em solid rgb(255, 255, 255);word-wrap: break-word !important;border-bottom: 0.6em solid transparent !important;border-right: 0.6em solid transparent !important;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;vertical-align: top;letter-spacing: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;text-align: justify;font-size: 15px;line-height: 1.8;color: rgb(62, 62, 62);word-wrap: break-word !important;\">\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\u3000\u30003\uff0e1\u9884BE\u8bd5\u9a8c\u7684\u76ee\u7684&nbsp;<\/strong><\/span><span class=\"Apple-converted-space\">&nbsp;<\/span>\u2460\u786e\u8ba4\u5236\u5242\u5904\u65b9\u6709\u65e0\u592a\u5927\u5dee\u5f02\u3002\u2461\u4f18\u5316\u6837\u54c1\u6536\u96c6\u65f6\u95f4\u95f4\u9694\uff0c\u6e05\u9664\u671f(\u6d17\u8131\u671f)\u7684\u65f6\u95f4\u662f\u5426\u8db3\u591f\uff0c\u836f\u52a8\u5b66\u66f2\u7ebf\u662f\u5426\u80fd\u591f\u5b8c\u6574\u8868\u73b0\u5438\u6536\u3001\u5206\u5e03\u3001\u4ee3\u8c22\u3001\u6392\u9664\u3002\u2462\u751f\u7269\u6837\u54c1\u7684\u5206\u6790\u65b9\u6cd5\u5b66\u662f\u5426\u6070\u5f53\uff0c\u4f8b\u5982:\u7ebf\u6027\u8303\u56f4\u662f\u5426\u5408\u9002\uff0c\u4ee3\u8c22\u4ea7\u7269\u7684\u5206\u6790\u65b9\u6cd5\u662f\u5426\u5408\u9002\u3002\u2463\u8bd5\u9a8c\u836f\u7269\u5728\u53d7\u8bd5\u8005\u4e2d\u7684\u53d8\u5f02\u6027:\u4ee5\u9884BE\u8bd5\u9a8c\u7684\u836f\u52a8\u5b66\u53c2\u6570\u7ed3\u679c\u8fdb\u884c\u6b63\u5f0f\u8bd5\u9a8c\u7684\u6837\u672c\u91cf\u4f30\u7b97\uff0c\u786e\u5b9a\u6837\u672c\u91cf\u5927\u5c0f\u4ee5\u83b7\u5f97\u8db3\u591f\u7684\u6210\u529f\u673a\u7387\u3002<\/p>\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000<span style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\u30003\uff0e2\u9884BE\u8bd5\u9a8c\u7684\u9002\u7528\u8303\u56f4<\/strong><\/span>&nbsp; \u5bf9\u4e8e\u4e00\u4e9b\u4eff\u5236\u836f\uff0c\u4e3a\u4e86\u89c4\u907f\u5904\u65b9\u5de5\u827a\u4e13\u5229\uff0c\u6216\u8005\u66f4\u6362\u4e86\u8f85\u6599\uff0c\u6216\u8005\u91c7\u7528\u7684\u5de5\u827a\u4e0d\u540c\u7b49\u539f\u56e0\u5bfc\u81f4\u4eff\u5236\u836f\u7684\u5904\u65b9\u5de5\u827a\u548c\u539f\u7814\u836f\u4e0d\u4e00\u81f4\uff0c\u5c24\u5176\u662f\u7f13\u63a7\u91ca\u4ea7\u54c1\uff0c\u901a\u5e38\u9700\u8981\u505a\u9884BE\u8bd5\u9a8c\u3002\u540c\u65f6\u5bf9\u590d\u6742\u5242\u578b\u548cBCS 2\u7c7b\u51e0\u4e4e\u5fc5\u505a\u9884BE\u8bd5\u9a8c\uff0c\u5f53\u7136\u4e5f\u53ef\u76f4\u63a5\u505aBE\u8bd5\u9a8c\uff0c\u4f46\u5931\u8d25\u53ef\u80fd\u6027\u5f88\u5927\u3002\u9884BE\u8bd5\u9a8c\u5728\u7f8e\u56fd\u4eff\u5236\u836f\u516c\u53f8\u662f\u5e38\u6001\uff0c\u672a\u6765\u5728\u56fd\u5185\u4e5f\u5e94\u6210\u201c\u65b0\u5e38\u6001\u201d\u3002\u4f46\u5e76\u4e0d\u662f\u8bf4\u6240\u6709\u7684\u836f\u90fd\u9700\u8981\u505a\u9884BE\u8bd5\u9a8c\uff0c\u6bd4\u5982BCS\u2160\u7c7b\u6216\u2162\u7c7b\u7684\u901f\u91ca\u836f\u7269\uff0c\u9884BE\u8bd5\u9a8c\u5c31\u6ca1\u6709\u592a\u5927\u7684\u5fc5\u8981\u3002<\/p>\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000<span style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">3\uff0e3\u9884BE\u8bd5\u9a8c\u7684\u4f8b\u6570&nbsp;<\/strong><\/span><span class=\"Apple-converted-space\">&nbsp;<\/span>\u76ee\u524d\u9884BE\u8bd5\u9a8c\u7684\u53d7\u8bd5\u8005\u4f8b\u6570\u6ca1\u6709\u7edf\u4e00\u89c4\u5b9a\uff0c\u901a\u5e38\u91c7\u75288\uff5e12\u4f8b\uff0c\u5982\u679c\u53d8\u5f02\u7cfb\u6570\u5927\u7684\uff0c\u53ef\u4ee5\u505a18\u4f8b\uff0c\u5bf9\u4e8e\u53d8\u5f02\u7cfb\u6570\u7279\u522b\u5927\u7684\uff0c\u751a\u81f3\u6709\u9884\u8bd5\u9a8c\u505a\u523024\u4f8b\u3002<\/p>\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000<span style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">3\uff0e4\u9884BE\u8bd5\u9a8c\u7684\u8bbe\u8ba1\u7c7b\u578b&nbsp;<span class=\"Apple-converted-space\">&nbsp;<\/span><\/strong><\/span>\u9884BE\u8bd5\u9a8c\u4e3b\u8981\u662f\u786e<span style=\"max-width: 100%;letter-spacing: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8ba42\u5236\u5242\u5728\u4f53\u5185\u7684\u53d8\u5f02\u7cfb\u6570\uff0c\u6240\u4ee5\u8981\u6267\u884c\u4ea4\u53c9\u8bbe\u8ba1\u624d\u80fd\u53d6\u5f97\u4f53\u5185intra CV\uff0c\u5e73\u884c\u8bd5\u9a8c\u8bbe\u8ba1\u9884\u6d4b\u7ed3\u679c\u6240\u83b7\u5f97\u7684\u53d8\u5f02\u6027\u6570\u636e\u53ea\u662f\u4e2a\u4f53\u95f4\u7684inter CV\uff0c\u65e0\u6cd5\u786e\u5b9a\u5236\u5242\u5904\u65b9\u5dee\u5f02\u8fd8\u662f\u5176\u4ed6\u5dee\u5f02\u9020\u6210\u7684\u5438\u6536\u5dee\u5f02\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000<span style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">3\uff0e5\u9884BE\u8bd5\u9a8c\u9910\u524d\u9910\u540e\u533a\u522b<\/strong><\/span>&nbsp; \u4e00\u822c\u60c5\u51b5\u4e0b\uff0c\u7a7a\u8179\u8bd5\u9a8c\u66f4\u5bb9\u6613\u63a2\u67e5\u5236\u5242\u95f4\u5dee\u5f02\uff0c\u5c06\u975e\u5236\u5242\u56e0\u7d20\u5f15\u8d77\u7684\u53d8\u5f02\u6700\u5c0f\u5316\u3002\u9910\u540e\u8bd5\u9a8c\u8003\u5bdf\u6700\u5927\u5f71\u54cd\u4e0b\u5236\u5242\u662f\u5426\u7b49\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 1px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 4px 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;vertical-align: top;background-color: rgb(44, 90, 160);word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: middle;color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">4 \u6837\u672c\u91cf\u7684\u8ba1\u7b97<\/strong><\/p>\n<\/section>\n<section style=\"margin-right: 3px;margin-left: 5px;max-width: 100%;box-sizing: border-box;width: 0px;border-left: 8px solid rgb(255, 255, 255);border-top: 5px solid transparent;border-bottom: 5px solid transparent;display: inline-block;vertical-align: middle;word-wrap: break-word !important;\"><\/section>\n<section style=\"margin-right: -9px;max-width: 100%;box-sizing: border-box;width: 0px;border-left: 8px solid rgb(255, 255, 255);border-top: 4px solid transparent;border-bottom: 4px solid transparent;display: inline-block;vertical-align: middle;transform: rotate(0deg);word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;width: 0px;border-left: 10px solid rgb(255, 255, 255);border-top: 6px solid transparent;border-bottom: 6px solid transparent;display: inline-block;vertical-align: middle;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 1px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;border-width: 2px 1px;border-style: none none dashed;border-color: rgb(44, 90, 160);border-radius: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: left;line-height: 1;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 0px;display: inline-block;border-top: 0.6em solid rgb(255, 255, 255);border-left: 0.6em solid rgb(255, 255, 255);word-wrap: break-word !important;border-bottom: 0.6em solid transparent !important;border-right: 0.6em solid transparent !important;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;vertical-align: top;letter-spacing: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;text-align: justify;font-size: 15px;line-height: 1.8;color: rgb(62, 62, 62);word-wrap: break-word !important;\">\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u6837\u672c\u91cf\u7684\u8ba1\u7b97\u6709\u67e5\u8868\u6cd5\u3001\u516c\u5f0f\u6cd5\u548c\u8f6f\u4ef6\u6cd5\uff0c\u6240\u5f97\u7ed3\u679c\u57fa\u672c\u4e00\u81f4\uff0c\u4f46\u9700\u8981\u6ce8\u660e\u8ba1\u7b97\u516c\u5f0f\u3001\u8868\u683c\u51fa\u5904\u6216\u8f6f\u4ef6\u7684\u7c7b\u578b\u53ca\u7248\u672c\u53f7\u3002<\/p>\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u516c\u5f0f\u6cd5:\u5728\u663e\u8457\u6027\u6c34\u5e73\u03b1\u8fbe\u5230(1-\u03b2)\u628a\u63e1\u5ea6\u6240\u9700\u7684\u53d7\u8bd5\u8005\u4f8b\u6570\u8ba1\u7b97\u5982\u516c\u5f0f1\uff3b10\uff3d\uff0cn\u4e3a\u6bcf\u4e2a\u5e8f\u5217\u53d7\u8bd5\u8005\u7684\u4f8b\u6570;\u4e24\u5468\u671f\u4ea4\u53c9\u8bd5\u9a8c\u6240\u9700\u603b\u53d7\u8bd5\u8005\u4f8b\u6570N=2n;\u03c32\u662f\u6b8b\u5dee\u65b9\u5dee\uff0c\u4e0e\u6240\u9700\u4f8b\u6570\u6210\u6b63\u76f8\u5173;\u03b8\u662f\u5236\u5242T\u548c\uff32\u6bd4\u503c\uff0c\u03b8\u8d8a\u504f\u79bb1\uff0c\u6240\u9700\u4f8b\u6570\u8d8a\u591a;\u03b4\u662fBE\u63a5\u53d7\u6807\u51c6\uff0c\u4e00\u822c\u53d6\u503cln 0\uff0e80\u6216ln 1\uff0e25\u3002<\/p>\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u5f53\u03b8=1\u65f6\uff0cn\u2265\uff3bt(\u03b1\uff0c2n\uff0d2)+t(\u03b2\uff0c2n\uff0d2)\uff3d2(\u03c32W\/ln 1\uff0e25)2;\u5f531\uff1c\u03b8\uff1c1\uff0e25\u65f6\uff0cn\u2265\uff3bt(\u03b1\uff0c2n\uff0d2)+t(\u03b2\uff0c2n\uff0d2)\uff3d2\uff3b\u03c32W\/(ln1\uff0e25\uff0dln\u03b8)\uff3d2;\u5f530\uff0e8\uff1c\u03b8\uff1c1\u65f6\uff0cn\u2265\uff3bt(\u03b1\uff0c2n\uff0d2)+t(\u03b2\uff0c2n\uff0d2)\uff3d2\uff3b\u03c32W\/(ln\u03b8\uff0dln0\uff0e8)\uff3d2&nbsp;\u3002&nbsp; &nbsp;\u516c\u5f0f1<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u67e5\u8868\u6cd5:\u5728\u03b1=0\uff0e05\uff0c\u76f8\u540c\u7684CV\u65f6\uff0c\u8981\u8fbe\u5230\u8f83\u9ad8\u7684\u628a\u63e1\u5ea6\uff0c\u6240\u9700\u8981\u7684\u53d7\u8bd5\u8005\u7684\u4f8b\u6570\u8d8a\u591a\uff0c\u56e0\u6b64\u8981\u8fbe\u523080%\u548c90%\u7684\u628a\u63e1\u5ea6\uff0c\u6240\u9700\u53d7\u8bd5\u8005\u4f8b\u6570N\u4e5f\u6709\u533a\u522b(\u89c1\u88681)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;word-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;word-wrap: break-word !important;width: 640px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/7-1544155422.jpg\" alt=\"\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u4f30\u7b97\u63a2\u8ba8\u2014\u2014\u57f9\u4f18BE\u7cfb\u521726\" title=\"\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u4f30\u7b97\u63a2\u8ba8\u2014\u2014\u57f9\u4f18BE\u7cfb\u521726\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;text-align: justify;font-size: 15px;line-height: 1.8;color: rgb(62, 62, 62);word-wrap: break-word !important;\">\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u8f6f\u4ef6\u6cd5:PASS\uff0cnQuery\uff0cS+\u548cSAS\u7b49\u8f6f\u4ef6\u90fd\u53ef\u4ee5\u8ba1\u7b97\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u7684\u6837\u672c\u91cf\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u6837\u672c\u542b\u91cf\u4f30\u8ba1\u4ee5\u836f\u52a8\u5b66\u53c2\u6570\u7684\u53d8\u5f02\u7cfb\u6570\u4e3a\u8ba1\u7b97\u6307\u6807\uff0c\u03b1=0\uff0e05\uff0c1\uff0d\u03b2=0\uff0e8\uff0cGM\uff32=0\uff0e95\uff0c\u7b49\u6548\u6807\u51c6\u4e3a80\uff0e00%\uff5e125\uff0e00%\uff0c\u53cc\u4ea4\u53c9\u8bbe\u8ba1\u8bd5\u9a8c\u7684\u8ba1\u7b97\u8fc7\u7a0b\u89c1\u56fe1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;word-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;word-wrap: break-word !important;width: 640px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/10-1544155422.jpg\" alt=\"\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u4f30\u7b97\u63a2\u8ba8\u2014\u2014\u57f9\u4f18BE\u7cfb\u521726\" title=\"\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u4f30\u7b97\u63a2\u8ba8\u2014\u2014\u57f9\u4f18BE\u7cfb\u521726\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;text-align: justify;font-size: 15px;line-height: 1.8;color: rgb(62, 62, 62);word-wrap: break-word !important;\">\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u8f6f\u4ef6\u6cd5\u548c\u67e5\u8868\u6cd5\u7684\u6bd4\u8f83:\u53ef\u4ee5\u770b\u51fa\uff0c\u5f53\u53d8\u5f02\u7cfb\u6570\u4e3a0\uff0e25\uff0c\u03b8=0\uff0e95\uff0c\u03b1=0\uff0e05\uff0c\u628a\u63e1\u5ea6\u4e3a80%\u65f6\uff0c\u8f6f\u4ef6\u6cd5\u548c\u67e5\u8868\u6cd5\u8ba1\u7b97\u7ed3\u679c\u5747\u4e3a28\u4f8b\uff0c\u7ed3\u679c\u4e00\u81f4\u3002<\/p>\n<p style=\"margin-bottom: 6px;max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u5bf9\u4e8e\u9ad8\u53d8\u5f02\u836f\u54c1(\u53d8\u5f02\u7cfb\u6570\uff1e30%)\uff0c\u53ef\u8fdb\u884c\u534a\u91cd\u590d\u6216\u5168\u91cd\u590d\u3001\u53c2\u6bd4\u5236\u5242\u6821\u6b63\u7684\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\uff0c\u6837\u672c\u91cf\u4f30\u8ba1\u53ef\u53c2\u8003\u76f8\u5173\u6587\u732e\uff3b10\uff3d\uff0cFDA\u63a8\u8350\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u4e0d\u5c11\u4e8e24\u4f8b\uff0c\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8ba1\u7b97\u7ed3\u679c\u4e3a\u7eb3\u5165\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u7684\u6837\u672c\u91cf\uff0c\u540c\u65f6\u5e94\u8003\u8651\u5230\u8bd5\u9a8c\u4e2d\u53d7\u8bd5\u8005\u8131\u843d\u7684\u53ef\u80fd\u6027\uff0c\u4e00\u822c\u9700\u8981\u6839\u636e\u8131\u843d\u7387\u9002\u5f53\u589e\u52a0\u4e00\u4e9b\u53d7\u8bd5\u8005\u5165\u7ec4\u8bd5\u9a8c\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u5bf9\u4e8e\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\uff0c\u53ef\u8fdb\u884c\u5168\u91cd\u590d\u3001\u53c2\u6bd4\u5236\u5242\u6821\u6b63\u7684\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u30022015\u5e74\u300a\u836f\u7269\u5236\u5242\u4eba\u4f53\u751f\u7269\u5229\u7528\u5ea6\u548c\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6307\u5bfc\u539f\u5219\u300b\u4e2d\u6307\u51fa:\u5bf9\u4e8e\u6cbb\u7597\u6307\u6570\u7a84\u7684\u836f\u54c1\u7684\u7279\u6b8a\u60c5\u51b5\uff0cAUC\u7684\u53ef\u63a5\u53d7\u533a\u95f4\u5e94\u8be5\u88ab\u7f29\u7a84\u4e3a90\uff0e00%\uff5e111\uff0e11%\u30022010\u5e744\u6708\u4ee5\u540e\uff0cFDA\u89c4\u5b9a\u5f53\u53c2\u6bd4\u5236\u5242\u4e2a\u4f53\u5185\u53d8\u5f02\u7cfb\u6570\uff1e21%\u65f6\uff0c\u53d7\u8bd5\u5236\u5242\u4e0e\u53c2\u6bd4\u5236\u5242\u836f\u52a8\u5b66\u53c2\u6570(AUC\uff0cCmax)\u7684\u51e0\u4f55\u5747\u6570\u6bd4\u503c\u768490%CI\u4e0d\u8d85\u8fc780.00%\uff5e125.00%\uff0c\u5982\u5229\u4f10\u6c99\u73ed;\u5f53\u53c2\u6bd4\u5236\u5242\u4e2a\u4f53\u5185\u53d8\u5f02\u7cfb\u6570\uff1c21%\u65f6\uff0c\u5e94\u6839\u636e\u53c2\u6bd4\u5236\u5242\u4e2a\u4f53\u5185\u53d8\u5f02\u7cfb\u6570\u7684\u5927\u5c0f\uff0c\u6210\u6bd4\u4f8b\u5730\u7f29\u7a8490%CI\uff0c\u5982\u534e\u6cd5\u6797\u3001\u6c28\u8336\u78b1\u3001\u5361\u9a6c\u897f\u5e73\u3001\u73af\u5b62\u7d20\u3001\u5730\u9ad8\u8f9b\uff0c90%CI\u5219\u4e3a90.00%\uff5e111.11%\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 1px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 4px 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;vertical-align: top;background-color: rgb(44, 90, 160);word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: middle;color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">5 \u6837\u672c\u91cf\u5927\u5c0f\u4e0e\u8bd5\u9a8c\u7ed3\u679c<\/strong><\/p>\n<\/section>\n<section style=\"margin-right: 3px;margin-left: 5px;max-width: 100%;box-sizing: border-box;width: 0px;border-left: 8px solid rgb(255, 255, 255);border-top: 5px solid transparent;border-bottom: 5px solid transparent;display: inline-block;vertical-align: middle;word-wrap: break-word !important;\"><\/section>\n<section style=\"margin-right: -9px;max-width: 100%;box-sizing: border-box;width: 0px;border-left: 8px solid rgb(255, 255, 255);border-top: 4px solid transparent;border-bottom: 4px solid transparent;display: inline-block;vertical-align: middle;transform: rotate(0deg);word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;width: 0px;border-left: 10px solid rgb(255, 255, 255);border-top: 6px solid transparent;border-bottom: 6px solid transparent;display: inline-block;vertical-align: middle;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 1px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;border-width: 2px 1px;border-style: none none dashed;border-color: rgb(44, 90, 160);border-radius: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: left;line-height: 1;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 0px;display: inline-block;border-top: 0.6em solid rgb(255, 255, 255);border-left: 0.6em solid rgb(255, 255, 255);word-wrap: break-word !important;border-bottom: 0.6em solid transparent !important;border-right: 0.6em solid transparent !important;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;vertical-align: top;letter-spacing: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;text-align: justify;font-size: 15px;line-height: 1.8;color: rgb(62, 62, 62);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u6837\u672c\u91cf\u7684\u5927\u5c0f\u4e0eGM\uff32\u7684(1\uff0d2\u03b1)\u7f6e\u4fe1\u533a\u95f4(\u4e00\u822c\u4e3a90%CI)\u6210\u8d1f\u76f8\u5173\uff3b11\uff3d\uff0c\u4e00\u9879\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u56e0\u6837\u672c\u91cf\u4e0d\u540c\u53ef\u80fd\u4ea7\u751f\u4ee5\u4e0b4\u79cd\u8bd5\u9a8c\u7ed3\u679c\uff3b12\uff3d:\u2460\u6837\u672c\u91cf\u8db3\u591f\uff0cGM\uff32\u7684(1\uff0d2\u03b1)\u7f6e\u4fe1\u533a\u95f4(\u4e00\u822c\u4e3a90%CI)\u5b8c\u5168\u843d\u5728\u89c4\u5b9a\u7684\u8303\u56f4\u5185(\u4e00\u822c\u4e3a80\uff0e00%\uff5e125\uff0e00%)\uff0c\u7ed3\u679c\u4e3a\u53ef\u4ee5\u5224\u65ad\u4e3a\u751f\u7269\u7b49\u6548\u3002\u2461\u6837\u672c\u91cf\u8db3\u591f\uff0cGM\uff32\u7684(1\uff0d2\u03b1)\u7f6e\u4fe1\u533a\u95f4\u5b8c\u5168\u4e0d\u5728\u89c4\u5b9a\u7684\u8303\u56f4\u5185\uff0c\u7ed3\u679c\u4e3a\u53ef\u4ee5\u5224\u65ad\u4e3a\u751f\u7269\u4e0d\u7b49\u6548\u3002\u2462\u6837\u672c\u91cf\u4e0d\u8db3\uff0cGM\uff32\u7684(1\uff0d2\u03b1)\u7f6e\u4fe1\u533a\u95f4\u5927\u90e8\u5206\u5728\u89c4\u5b9a\u7684\u8303\u56f4\u5185\uff0c\u7ed3\u679c\u4e3a\u4e0d\u80fd\u5224\u65ad\u4e3a\u751f\u7269\u7b49\u6548\uff0c\u53ef\u80fd\u72af\u4e8c\u7c7b\u9519\u8bef\uff0c\u5373\u5c06\u7b49\u6548\u7684\u8bd5 \u9a8c \u836f \u5224 \u4e3a \u4e0d \u7b49 \u6548\u3002\u2463 \u6837 \u672c \u91cf \u4e0d \u8db3\uff0cGM\uff32 \u7684( 1 \uff0d 2\u03b1) \u7f6e\u4fe1\u533a\u95f4\u5927\u90e8\u5206\u4e0d\u5728\u89c4\u5b9a\u7684\u8303\u56f4\u5185\uff0c\u7ed3\u679c\u4e3a\u4e0d\u80fd\u5224\u65ad\u4e3a\u751f\u7269\u4e0d\u7b49\u6548\u3002\u89c1\u56fe 2\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;word-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;word-wrap: break-word !important;width: 596px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/7-1544155422-1.jpg\" alt=\"\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u4f30\u7b97\u63a2\u8ba8\u2014\u2014\u57f9\u4f18BE\u7cfb\u521726\" title=\"\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u4f30\u7b97\u63a2\u8ba8\u2014\u2014\u57f9\u4f18BE\u7cfb\u521726\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;text-align: justify;font-size: 15px;line-height: 1.8;color: rgb(62, 62, 62);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u5e94\u6839\u636e\u5177\u4f53\u60c5\u51b5\uff0c\u5206\u6790\u5e76\u51b3\u5b9a\u8bd5\u9a8c\u7684\u6210\u8d25\uff0c\u6216\u8005\u53d7\u8bd5\u5236\u5242\u7684\u53d6\u820d\u6216\u6539\u8fdb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 1px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 4px 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;vertical-align: top;background-color: rgb(44, 90, 160);word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: middle;color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">6 \u6837\u672c\u91cf\u786e\u5b9a\u7684\u5efa\u8bae<\/strong><\/p>\n<\/section>\n<section style=\"margin-right: 3px;margin-left: 5px;max-width: 100%;box-sizing: border-box;width: 0px;border-left: 8px solid rgb(255, 255, 255);border-top: 5px solid transparent;border-bottom: 5px solid transparent;display: inline-block;vertical-align: middle;word-wrap: break-word !important;\"><\/section>\n<section style=\"margin-right: -9px;max-width: 100%;box-sizing: border-box;width: 0px;border-left: 8px solid rgb(255, 255, 255);border-top: 4px solid transparent;border-bottom: 4px solid transparent;display: inline-block;vertical-align: middle;transform: rotate(0deg);word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;width: 0px;border-left: 10px solid rgb(255, 255, 255);border-top: 6px solid transparent;border-bottom: 6px solid transparent;display: inline-block;vertical-align: middle;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 1px;line-height: 27.2px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;border-width: 2px 1px;border-style: none none dashed;border-color: rgb(44, 90, 160);border-radius: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: left;line-height: 1;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 0px;display: inline-block;border-top: 0.6em solid rgb(255, 255, 255);border-left: 0.6em solid rgb(255, 255, 255);word-wrap: break-word !important;border-bottom: 0.6em solid transparent !important;border-right: 0.6em solid transparent !important;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 10px;padding-bottom: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 669px;vertical-align: top;letter-spacing: 0px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;text-align: justify;font-size: 15px;line-height: 1.8;color: rgb(62, 62, 62);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u3000\u3000\u603b\u4f53\u800c\u8a00\uff0c\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u7684\u6700\u7ec8\u786e\u5b9a\uff0c\u9700\u8981\u6839\u636e\u56fd\u5185\u5916\u7684\u6307\u5bfc\u539f\u5219\u548c\u76f8\u5173\u6587\u732e\u62a5\u9053\u6216\u65e2\u5f80\u7814\u7a76\u7ed3\u679c\uff0c\u7ed3\u5408\u8bd5\u9a8c\u7ecf\u9a8c\u6765\u8fdb\u884c\u4f30\u7b97\u3002\u5177\u4f53\u4e3a:\u2460\u8981\u6839\u636e\u8bd5\u9a8c\u8bbe\u8ba1\u7c7b\u578b\u3001\u751f\u7269\u7b49\u6548\u5224\u65ad\u6807\u51c6\u548c\u76f8\u5173\u7edf\u8ba1\u5b66\u8981\u6c42\uff0c\u91c7\u7528\u5408\u9002\u7684\u65b9\u6cd5\u786e\u5b9a\u6837\u672c\u91cf\uff0c\u65e0\u6cd5\u5f97\u5230\u76f8\u5173\u62a5\u9053\u7684\u836f\u7269\uff0c\u6700\u597d\u5f00\u5c55\u9884\u8bd5\u9a8c\uff0c\u6839\u636e\u9884\u8bd5\u9a8c\u7684\u7ed3\u679c\u6765\u4f30\u7b97\u6837\u672c\u91cf\u3002\u24612\u00d72\u4ea4\u53c9\u8bbe\u8ba1\u7684\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u7684\u53ef\u8bc4\u4ef7\u53d7\u8bd5\u8005\u4e0d\u5e94\u5c11\u4e8e12\u4f8b\uff0c\u9ad8\u53d8\u5f02\u836f\u54c1\u534a\u91cd\u590d\u6216\u5168\u91cd\u590d\u3001\u53c2\u6bd4\u5236\u5242\u6821\u6b63\u7684\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u7684\u53ef\u8bc4\u4ef7\u53d7\u8bd5\u8005\u4e00\u822c\u4e0d\u5e94\u5c11\u4e8e24\u4f8b\uff3b13\uff3d\uff0c\u8003\u8651\u5230\u53d7\u8bd5\u8005\u8131\u843d\u7b49\u56e0\u7d20\uff0c\u5e94\u7b5b\u9009\u5408\u9002\u7684\u53d7\u8bd5\u8005\u5165\u7ec4\u8bd5\u9a8c\u3002\u2462\u53d7\u8bd5\u8005\u7684\u5254\u9664\u548c\u8ffd\u52a0\u5fc5\u987b\u6709\u5145\u5206\u7406\u7531\uff0c\u5e76\u5728\u8bd5\u9a8c\u65b9\u6848\u6216\u76f8\u5173\u6807\u51c6\u64cd\u4f5c\u89c4\u7a0b\u4e2d\u4e8b\u5148\u660e\u786e\u3002\u2463\u4e0d\u5efa\u8bae\u8f7b\u6613\u6539\u53d8\u8bd5\u9a8c\u8bbe\u8ba1\u7c7b\u578b\uff0c\u4f8b\u5982\u9884BE\u6267\u884c\u4ea4\u53c9\u8bd5\u9a8c\uff0c\u9884\u4f30\u4ea4\u53c9\u8bd5\u9a8c\u53d7\u8bd5\u8005\u4f8b\u6570 n\uff0c\u6b63\u5f0f\u8bd5\u9a8c\u6539\u4e3a\u5e73\u884c 2n\u4f8b\uff0c\u7ed3\u679c\u5931\u8d25\u7684\u53ef\u80fd\u6027\u4f1a\u52a0\u5927\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;text-align: left;\"><span style=\"font-size: 14px;\"><strong>\u3010\u8f6c\u81ea\uff1a\u534e\u666e\u533b\u836f\u3011<\/strong><\/span><\/p>\n<section px=\"px\" border-box=\"border-box\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" microsoft=\"microsoft\" arial=\"arial\" sans-serif=\"sans-serif\" normal=\"normal\" important=\"important\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\" break-word=\"break-word\" style=\"white-space: normal;text-align: justify;color: rgb(51, 51, 51);letter-spacing: 0.54px;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;\">\n<section class=\"\"    style=\"max-width: 100%;color: rgb(62, 62, 62);\">\n<section style=\"padding: 10px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;line-height: 28px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"letter-spacing: 0.5px;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/10-1544155423.jpeg\" alt=\"\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u4f30\u7b97\u63a2\u8ba8\u2014\u2014\u57f9\u4f18BE\u7cfb\u521726\" title=\"\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u6837\u672c\u91cf\u4f30\u7b97\u63a2\u8ba8\u2014\u2014\u57f9\u4f18BE\u7cfb\u521726\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"   style=\"max-width: 100%;color: rgb(62, 62, 62);\">\n<section  style=\"max-width: 100%;width: 558px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin: 10px auto;max-width: 100%;width: 280px;height: 110px;background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/6-1544155423.jpeg');background-repeat: no-repeat;background-size: 100%;overflow: hidden;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-top: 8px;margin-left: 180px;max-width: 100%;width: 95px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section label=\"Powered by 135editor.com\"  class=\"\" style=\"max-width: 100%;color: rgb(34, 34, 34);font-size: 14px;line-height: 28.44px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;word-wrap: break-word !important;\">\n<section   style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section randomid=\"97553\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-right: auto;margin-left: auto;max-width: 100%;clear: both;width: 670px;overflow: hidden;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-right: auto;margin-left: auto;max-width: 100%;clear: both;width: 670px;overflow: hidden;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"display: inline-block;max-width: 100%;box-sizing: border-box;border-radius: 0.7em;border-width: 0.14em;border-style: solid;border-color: rgb(0, 0, 0);width: 556px;box-shadow: rgb(204, 204, 204) 0.2em 0.2em 0.3em;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 10px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(171, 25, 66);box-sizing: border-box !important;word-wrap: break-word !important;\">\u514d\u8d23\u58f0\u660e\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u672c\u6587\u4fe1\u606f\u90e8\u5206\u5185\u5bb9\u6765\u81ea\u7f51\u7edc\u6587\u7ae0\uff0c\u4e0d\u4fdd\u8bc1\u6240\u6709\u4fe1\u606f\u3001\u6587\u672c\u3001\u56fe\u5f62\u3001\u94fe\u63a5\u53ca\u5176\u4ed6\u9879\u76ee\u7684\u7edd\u5bf9\u51c6\u786e\u6027\u548c\u5b8c\u6574\u6027\uff0c\u6545\u4ec5\u4f9b\u8bbf\u95ee\u8005\u53c2\u7167\u9002\u7528\u3002\u5982\u60a8\uff08\u5355\u4f4d\u6216\u4e2a\u4eba\uff09\u8ba4\u4e3a\u672c\u6587\u67d0\u90e8\u5206\u5185\u5bb9\u6709\u4fb5\u6743\u5acc\u7591\uff0c\u656c\u8bf7\u7acb\u5373\u901a\u77e5\u6211\u4eec\uff0c\u6211\u4eec\u5c06\u5728\u7b2c\u4e00\u65f6\u95f4\u4e88\u4ee5\u66f4\u6b63\u6216\u5220\u9664\u3002\u4ee5\u4e0a\u58f0\u660e\u4e4b\u89e3\u91ca\u6743\u5f52\u672c\u516c\u4f17\u53f7\u6240\u6709\u3002\u6cd5\u5f8b\u4e0a\u6709\u76f8\u5173\u89e3\u91ca\u7684\uff0c\u4ee5\u4e2d\u56fd\u6cd5\u5f8b\u4e4b\u89e3\u91ca\u4e3a\u57fa\u51c6\u3002\u5982\u6709\u4e89\u8bae\u9650\u5728\u6211\u65b9\u6240\u5728\u5730\u53f8\u6cd5\u90e8\u95e8\u89e3\u51b3\u3002\u8c22\u8c22\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\uff3b\u6458\u8981\uff3d\u968f\u7740\u6211\u56fd\u4eff\u5236\u836f\u8d28\u91cf\u4e0e\u7597\u6548\u4e00\u81f4\u6027\u8bc4\u4ef7\u7684\u5168\u9762\u5f00\u5c55\uff0c\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u4f5c\u4e3a\u4e00\u81f4\u6027\u8bc4\u4ef7\u7684\u91cd\u70b9\u5185\u5bb9\u5c06\u8fce\u6765\u9ad8\u5cf0\uff0c\u5bf9 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":66629,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/66628"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=66628"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/66628\/revisions"}],"predecessor-version":[{"id":66637,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/66628\/revisions\/66637"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/66629"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=66628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=66628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=66628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}