{"id":66735,"date":"2018-10-09T01:00:00","date_gmt":"2018-12-07T04:05:05","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/a94a6ce582\/"},"modified":"2018-12-07T12:05:07","modified_gmt":"2018-12-07T04:05:07","slug":"a94a6ce582","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/66735\/","title":{"rendered":"\u63a2\u8ba8\u9884BE\u8bd5\u9a8c\u7684\u76ee\u7684\u548c\u610f\u4e49\u2014\u2014\u57f9\u4f18BE\u7cfb\u521723"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"_135editor\" style=\"border: 0px currentColor;box-sizing: border-box;\"  >\n<section style=\"width: 100%;overflow: hidden;\" >\n<section border-radius=\"\" http=\"\" png=\"\" px=\"px\" quot=\"\" border-box=\"border-box\">\n<section style=\"padding-top: 5px;margin-left: 5px;box-sizing: border-box;\">\n<section class=\"135brush\" style=\"background: rgb(248, 248, 248);padding: 1em 0.7em;border-radius: 5px 5px 0px;text-align: justify;color: rgb(51, 51, 50);line-height: 1.75em;font-size: 14px;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"text-align: left;vertical-align: middle;display: inline-block;box-sizing: border-box;\">\n<section style=\"width: 6.5em;box-sizing: border-box;\">\n<section style=\"width: 80%;display: inline-block;max-width: 100%;box-sizing: border-box;\"><\/section>\n<section style=\"width: 80%;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"width: 100% !important;height: auto !important;vertical-align: middle;visibility: visible !important;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/4-1544155506.png\" alt=\"\u63a2\u8ba8\u9884BE\u8bd5\u9a8c\u7684\u76ee\u7684\u548c\u610f\u4e49\u2014\u2014\u57f9\u4f18BE\u7cfb\u521723\" title=\"\u63a2\u8ba8\u9884BE\u8bd5\u9a8c\u7684\u76ee\u7684\u548c\u610f\u4e49\u2014\u2014\u57f9\u4f18BE\u7cfb\u521723\"  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style=\"text-align: left;vertical-align: middle;display: inline-block;box-sizing: border-box;\">\n<section style=\"width: 6.5em;box-sizing: border-box;\">\n<section style=\"width: 80%;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"width: 100% !important;height: auto !important;vertical-align: middle;visibility: visible !important;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/3-1544155506.png\" alt=\"\u63a2\u8ba8\u9884BE\u8bd5\u9a8c\u7684\u76ee\u7684\u548c\u610f\u4e49\u2014\u2014\u57f9\u4f18BE\u7cfb\u521723\" title=\"\u63a2\u8ba8\u9884BE\u8bd5\u9a8c\u7684\u76ee\u7684\u548c\u610f\u4e49\u2014\u2014\u57f9\u4f18BE\u7cfb\u521723\"  \/><\/section>\n<\/section>\n<section style=\"text-align: center;color: rgb(90, 161, 129);line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: 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style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\u7efc\u5408\u4eff\u5236\u836fAPI\u7684\u7269\u7406\uff0c\u5316\u5b66\u548c\u751f\u7269\u5b66\u6027\u8d28\u3001\u5242\u578b\uff08\u901f\u91ca\u3001\u7f13\u63a7\u91ca\uff09\u3001\u5236\u5242\u6709\u65e0\u4e13\u5229\u7b49\u5224\u65adBE\u8bd5\u9a8c\u7684\u96be\u6613\u7a0b\u5ea6\uff0c\u51b3\u5b9a\u662f\u5426\u9700\u8981\u5f00\u5c55\u9884BE\u8bd5\u9a8c\u4ee5\u53ca\u9884BE\u8bd5\u9a8c\u9700\u8981\u89e3\u51b3\u54ea\u4e9b\u95ee\u9898\u3002\u4e00\u822c\u60c5\u51b5\u4e0b\uff0c\u4ee5\u4e0b\u60c5\u5f62\u5f00\u5c55\u9884BE\u8bd5\u9a8c\u6709\u5229\u4e8e\u4e3a\u6b63\u5f0fBE\u8bd5\u9a8c\u63d0\u4f9b\u53c2\u8003\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000<span style=\"color: rgb(90, 161, 129);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u53e3\u670d\u901f\u91ca\u5236\u5242<\/strong><\/span>\uff08\u4e0d\u5305\u62ec\u53e3\u5d29\u7247\uff0c\u53e3\u542b\u7247\u7b49\uff09<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\uff081\uff09\u5927\u90e8\u5206BCS4\u7c7b\uff0c\u90e8\u5206BCS2\u7c7b\uff1b<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\uff082\uff09\u5927\u90e8\u5206\u9ad8\u53d8\u5f02\u836f\u7269\uff1b<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\uff083\uff09\u7a84\u6cbb\u7597\u7a97\u836f\u7269\uff1b<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\uff084\uff09\u5927\u90e8\u5206\u80c3\u80a0\u9053\u4e0d\u7a33\u5b9a\u7684\u836f\u7269\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000<strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(90, 161, 129);box-sizing: border-box;\">\u6311\u6218\u5236\u5242\u4e13\u5229\u7684\u836f\u7269<\/span><\/strong><\/p>\n<p style=\"white-space: normal;box-sizing: 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border-box;\">\u5185\u6e90\u6027\u7269\u8d28<\/span><\/strong><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\u5185\u6e90\u6027\u7269\u8d28\u672c\u8eab\u6bd4\u8f83\u590d\u6742\u4e14\u53d8\u5f02\u7a0b\u5ea6\u5f88\u9ad8\uff0c\u5f00\u5c55\u9884BE\u8bd5\u9a8c\u4e3b\u8981\u4e86\u89e3\u53d7\u8bd5\u5236\u5242\u4e0e\u53c2\u6bd4\u5236\u5242\u5728\u4f53\u5185\u7684\u57fa\u7ebf\u53d8\u5316\u60c5\u51b5\uff0c\u4ee5\u53ca\u5bf9\u8bd5\u9a8c\u7a0b\u5e8f\u548c\u64cd\u4f5c\u8fdb\u884c\u786e\u8ba4\uff0c\u4e3a\u6b63\u5f0fBE\u8bd5\u9a8c\u6253\u4e0b\u57fa\u7840\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"text-align: left;vertical-align: middle;display: inline-block;box-sizing: border-box;\">\n<section style=\"width: 6.5em;box-sizing: border-box;\">\n<section style=\"width: 80%;display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"width: 100% !important;height: auto !important;vertical-align: middle;visibility: visible !important;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/10-1544155506.png\" alt=\"\u63a2\u8ba8\u9884BE\u8bd5\u9a8c\u7684\u76ee\u7684\u548c\u610f\u4e49\u2014\u2014\u57f9\u4f18BE\u7cfb\u521723\" title=\"\u63a2\u8ba8\u9884BE\u8bd5\u9a8c\u7684\u76ee\u7684\u548c\u610f\u4e49\u2014\u2014\u57f9\u4f18BE\u7cfb\u521723\"  \/><\/section>\n<\/section>\n<section style=\"text-align: center;color: rgb(90, 161, 129);line-height: 2;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u4ece\u9884BE\u8bd5\u9a8c\u4e2d\u5f97\u5230\u7684\u4fe1\u606f\u6570\u636e<\/strong><\/p>\n<\/section>\n<section style=\"width: 6.5em;margin-left: auto;box-sizing: border-box;\">\n<section style=\"display: inline-block;max-width: 100%;box-sizing: border-box;\"><img style=\"width: 640px !important;height: auto !important;vertical-align: middle;visibility: visible !important;box-sizing: border-box;\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/9-1544155506.png\" alt=\"\u63a2\u8ba8\u9884BE\u8bd5\u9a8c\u7684\u76ee\u7684\u548c\u610f\u4e49\u2014\u2014\u57f9\u4f18BE\u7cfb\u521723\" title=\"\u63a2\u8ba8\u9884BE\u8bd5\u9a8c\u7684\u76ee\u7684\u548c\u610f\u4e49\u2014\u2014\u57f9\u4f18BE\u7cfb\u521723\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;color: rgb(110, 110, 110);font-size: 15px;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\u8be5\u90e8\u5206\u7ed3\u5408\u5b9e\u9645\u9884BE\u8bd5\u9a8c\u7684\u7ed3\u679c\u6570\u636e\u8fdb\u884c\u8ba8\u8bba\uff0c\u901a\u8fc7\u9884BE\u8bd5\u9a8c\u53ef\u4ee5\u5f97\u5230\u4ee5\u4e0b\u91cd\u8981\u4fe1\u606f\uff1a<\/p>\n<p style=\"text-align: center;\"><img       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/4-1544155507.jpeg\" alt=\"\u63a2\u8ba8\u9884BE\u8bd5\u9a8c\u7684\u76ee\u7684\u548c\u610f\u4e49\u2014\u2014\u57f9\u4f18BE\u7cfb\u521723\" title=\"\u63a2\u8ba8\u9884BE\u8bd5\u9a8c\u7684\u76ee\u7684\u548c\u610f\u4e49\u2014\u2014\u57f9\u4f18BE\u7cfb\u521723\"><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\u8840\u836f\u5cf0\u6d53\u5ea6(Cmax)\uff0c\u836f\u65f6\u66f2\u7ebf\u4e0b\u9762\u79ef(AUClast,AUC inf)\u768490%\u7f6e\u4fe1\u5ea6\u533a\u95f4\u2014\u2014\u5224\u65ad\u53d7\u8bd5\u5236\u5242\u4e0e\u53c2\u6bd4\u5236\u5242\u5728\u4f53\u5185\u7684\u5438\u6536\u8868\u73b0\u662f\u5426\u4e00\u81f4\u7684\u4e24\u9879\u91cd\u8981\u6307\u6807\uff1a<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\uff081\uff09\u51e0\u4f55\u5747\u503c(Geometrics mean)<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\uff082\uff09\u6bd4\u503c(Ratio)<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\u53d7\u8bd5\u5236\u5242T\u548c\u53c2\u6bd4\u5236\u5242R\u836f\u52a8\u53c2\u6570\uff08Cmax\u3001AUCt\u3001AUCinf\uff09\u51e0\u4f55\u5747\u503c\u7684\u6bd4\u7387\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\uff083\uff09\u6743\u91cd(Power)\u628a\u63e1\u5ea6\uff0c\u662f\u6307power of test statistic\uff0c\u662f\u7edf\u8ba1\u91cf\u7684\u201c\u7edf\u8ba1\u68c0\u9a8c\u529b\u201d\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\uff084\uff09\u4e2a\u4f53\u5185\u53d8\u5f02(Intra-subject CV)\u2014\u2014\u9884\u4f30\u6b63\u5f0fBE\u8bd5\u9a8c\u6837\u672c\u91cf\u7684\u91cd\u8981\u6307\u6807<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\u4e00\u822c\u6765\u8bb2\uff0c\u662f\u6307\u540c\u4e00\u4e2a\u4eba\u5728\u4e0d\u540c\u65f6\u95f4\u5403\u540c\u4e00\u79cd\u836f\u7269\uff0c\u4f53\u5185\u836f\u4ee3\u884c\u4e3a\u4e0d\u4e00\u81f4\u5bfc\u81f4\u836f\u52a8\u53c2\u6570\u7684\u5dee\u5f02\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u3000\u3000\u5bf9\u9884BE\u8bd5\u9a8c\u7ed3\u679c\u7684\u5206\u6790\uff0c\u9700\u8981\u6839\u636e\u5177\u4f53\u54c1\u79cd\u5f00\u5c55\u9884BE\u8bd5\u9a8c\u7684\u76ee\u7684\uff0c\u5bf9\u4ee5\u4e0a\u5404\u9879\u6570\u636e\u8fdb\u884c\u7efc\u5408\u5206\u6790\uff0c\u5224\u65ad\u662f\u5426\u8fbe\u5230\u4e86\u9884\u671f\u7684\u76ee\u7684\uff0c\u4e3a\u5904\u65b9\u5de5\u827a\u8c03\u6574\u6216\u6b63\u5f0fBE\u8bd5\u9a8c\u7684\u8bbe\u8ba1\u548c\u5b9e\u65bd\u63d0\u4f9b\u652f\u6301\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: left;white-space: normal;\"><span style=\"font-size: 14px;\"><strong>\u3010\u8f6c\u81ea\uff1a\u6850\u8f89\u836f\u4e1a\u3011<\/strong><\/span><\/p>\n<section style=\"text-align: justify;color: rgb(51, 51, 51);letter-spacing: 0.54px;\" px=\"px\" border-box=\"border-box\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" gb=\"gb\" ui=\"ui\" microsoft=\"microsoft\" arial=\"arial\" sans-serif=\"sans-serif\" normal=\"normal\" important=\"important\" helvetica=\"helvetica\" sans=\"sans\" yahei=\"yahei\" break-word=\"break-word\">\n<section style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box !important;\">\n<section style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box !important;\" >\n<section style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box !important;\">\n<section style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box !important;\">\n<section style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box !important;\" >\n<section style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box !important;\">\n<section style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box !important;\">\n<section style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box !important;\">\n<p style=\"-ms-word-wrap: break-word !important;min-height: 1em;max-width: 100%;box-sizing: border-box !important;\"><img width=\"auto\" style=\"width: auto !important;visibility: visible !important;-ms-word-wrap: break-word !important;box-sizing: border-box !important;\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/8-1544155507.jpg\" alt=\"\u63a2\u8ba8\u9884BE\u8bd5\u9a8c\u7684\u76ee\u7684\u548c\u610f\u4e49\u2014\u2014\u57f9\u4f18BE\u7cfb\u521723\" 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break-word !important;max-width: 100%;box-sizing: border-box !important;\">\n<section style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box !important;\">\n<section style=\"width: 670px;overflow: hidden;clear: both;margin-right: auto;margin-left: auto;-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box !important;\">\n<section style=\"line-height: 25.6px;-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box !important;\" >\n<section style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box;\">\n<section style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box;\">\n<section style=\"border-radius: 0.7em;border: 0.14em solid rgb(0, 0, 0);width: 556px;display: inline-block;-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box;box-shadow: 0.2em 0.2em 0.3em rgb(204,204,204);\">\n<section style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box;\">\n<section style=\"padding: 10px;-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box;\">\n<section style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box;\">\n<section style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box;\">\n<p style=\"-ms-word-wrap: break-word !important;min-height: 1em;max-width: 100%;box-sizing: border-box !important;\"><span style=\"color: rgb(171, 25, 66);-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box !important;\">\u514d\u8d23\u58f0\u660e\uff1a<\/span><\/p>\n<p style=\"-ms-word-wrap: break-word !important;min-height: 1em;max-width: 100%;box-sizing: border-box !important;\"><span style=\"-ms-word-wrap: break-word !important;max-width: 100%;box-sizing: border-box 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