{"id":67530,"date":"2018-11-15T01:00:00","date_gmt":"2018-12-07T04:15:42","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/904a8f090b\/"},"modified":"2018-12-07T12:15:46","modified_gmt":"2018-12-07T04:15:46","slug":"904a8f090b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/67530\/","title":{"rendered":"\u3010BioWorld Science\u30112018\u5e7410\u6708\u836f\u7269\u5feb\u8baf_\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001"},"content":{"rendered":"
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\u4e2d\u6587\u7ffb\u8bd1\uff1a\u963f\u6817\u535a\u58eb<\/span><\/p>\n

Daily Drug News \u5df2\u6b63\u5f0f\u66f4\u540d\u4e3aBioWorld Science<\/span><\/p>\n


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    2018\u5e7410\u67081\u65e5\uff0c\u8054\u5408\u6297\u4f53\u6291\u5236\u827e\u6ecb\u75c5\u6bd2\u53ca\u5176\u8010\u836f\u6027<\/p>\n<\/li>\n

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    2018\u5e7410\u670819\u65e5\uff0cST Pharm\u516c\u53f8\u53d1\u73b0\u65b0\u7684HIV\u6574\u5408\u9176\u6291\u5236\u5242<\/p>\n<\/li>\n<\/ul>\n

    \u751f\u7269\u6807\u5fd7\u7269<\/span><\/p>\n

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      2018\u5e7410\u670816\u65e5\uff0cADAMTS7\u6216\u53ef\u4f5c\u4e3a2\u578b\u7cd6\u5c3f\u75c5\u65e9\u671f\u5de6\u5ba4\u8212\u5f20\u548c\u6536\u7f29\u529f\u80fd\u969c\u788d\u7684\u4e34\u5e8a\u6307\u6807<\/p>\n<\/li>\n

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      2018\u5e7410\u67085\u65e5\uff0cC1QBP\u53ef\u7528\u6765\u9884\u6d4b\u95f4\u76ae\u7624\u60a3\u8005\u5316\u7597\u540e\u7684\u751f\u5b58\u671f<\/p>\n<\/li>\n<\/ul>\n

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        2018\u5e7410\u670824\u65e5\uff0c\u62dc\u8033\u5236\u836f\u53d1\u73b0\u65b0\u7684CDK9\u6291\u5236\u5242<\/p>\n<\/li>\n

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        2018\u5e7410\u670817\u65e5\uff0c\u53f0\u5317\u533b\u79d1\u5927\u5b66\u53d1\u73b0\u65b0\u578bHSP90\u6291\u5236\u5242<\/p>\n<\/li>\n

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        2018\u5e7410\u670816\u65e5\uff0c\u6297\u80bf\u7624\u9776\u5411\u6cbb\u7597\u5bfc\u81f4\u7ec6\u80de\u547d\u8fd0\u7684\u8f6c\u53d8<\/p>\n<\/li>\n<\/ul>\n

        \u80bf\u7624\u514d\u75ab\u6cbb\u7597<\/span><\/p>\n

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          2018\u5e7410\u67081\u65e5\uff0c\u53cc\u7279\u5f02\u6027\u951a\u5b9a\u7684\u7ec6\u80de\u6bd2\u6fc0\u6d3b\u56e0\u5b50\u6297\u4f53\u80fd\u591f\u8bf1\u5bfc\u5375\u5de2\u764c\u7ec6\u80de\u6b7b\u4ea1<\/p>\n<\/li>\n

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          2018\u5e7410\u670822\u65e5\uff0cGITR\u6fc0\u52a8\u5242MEDI-1873\u7684\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u6570\u636e\u5728ESMO\u4f1a\u8bae\u4e0a\u516c\u5e03<\/p>\n<\/li>\n

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          2018\u5e7410\u670819\u65e5\uff0cMM-121\u6cbb\u7597NSCLC\u65e0\u6548\uff0cMerrimack\u516c\u53f8\u7ec8\u6b62\u4e86\u540d\u4e3aSHERLOC\u7684\u4e34\u5e8a\u7814\u7a76<\/p>\n<\/li>\n

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          2018\u5e7410\u670831\u65e5\uff0cFDA\u6279\u51c6Keytruda\u4e0e\u5316\u7597\u8054\u5408\u7528\u4e8e\u4e00\u7ebf\u8f6c\u79fb\u6027\u9cde\u72b6NSCLC\u7684\u6cbb\u7597<\/p>\n<\/li>\n<\/ul>\n

          \u5fc3\u8840\u7ba1\u75be\u75c5<\/span><\/p>\n

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            2018\u5e7410\u670810\u65e5\uff0c\u6297\u80bf\u7624\u836f\u7269\u6216\u53ef\u88ab\u7528\u4e8e\u6cbb\u7597\u708e\u75c7<\/p>\n<\/li>\n<\/ul>\n

            \u76ae\u80a4\u75c5<\/span><\/p>\n

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              2018\u5e7410\u670809\u65e5\uff0c\u4e2d\u91cd\u5ea6\u5934\u76ae\u94f6\u5c51\u75c5\u836f\u7269Otezla\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9<\/p>\n<\/li>\n<\/ul>\n

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                2018\u5e7410\u670823\u65e5\uff0c\u65b0\u578b\u524d\u5217\u817a\u764c\u793a\u8e2a\u5242[18F]PSMA-7\u8fdb\u5165\u4e34\u5e8a\u5e94\u7528<\/p>\n<\/li>\n<\/ul>\n

                \u836f\u7269\u8bbe\u8ba1\u4e0e\u6280\u672f<\/span><\/p>\n

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                  2018\u5e7410\u670825\u65e5\uff0cAlexion\u548cDicerna\u5ba3\u5e03\u5408\u4f5c\u5f00\u53d1RNAi\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u8865\u4f53\u4ecb\u5bfc\u7684\u75be\u75c5<\/p>\n<\/li>\n<\/ul>\n

                  \u5185\u5206\u6ccc\u7cfb\u7edf\u75be\u75c5<\/span><\/p>\n

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                    2018\u5e7410\u670826\u65e5\uff0cSGLT1\u7a81\u53d8\u80fd\u591f\u964d\u4f4e\u9910\u540e\u8840\u7cd6\uff0c\u53ef\u5bf9\u957f\u671f\u5fc3\u8840\u7ba1\u4ee3\u8c22\u98ce\u9669\u8d77\u5230\u4fdd\u62a4\u4f5c\u7528<\/p>\n<\/li>\n

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                    2018\u5e7410\u670809\u65e5\uff0c\u80f0\u5c9b\u7ec6\u80de\u8868\u8fbe\u201c\u5148\u5929\u514d\u75ab\u201d\u86cb\u767d<\/p>\n<\/li>\n<\/ul>\n

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                      2018\u5e7410\u670829\u65e5\uff0c\u8f89\u745e\u548c\u8bfa\u534e\u5c06\u5408\u4f5c\u7814\u7a76NASH\u8054\u5408\u7597\u6cd5<\/p>\n<\/li>\n<\/ul>\n

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                        2018\u5e7410\u67082\u65e5\uff0cButantan\u7814\u7a76\u6240\u7684H7N9\u6d41\u611f\u6297\u539f\u8fdb\u884cI\u671f\u7814\u7a76<\/p>\n<\/li>\n<\/ul>\n

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                          2018\u5e7410\u670810\u65e5\uff0c\u7528\u6765\u63d0\u9ad8\u7684\u5b89\u5168\u6027\u65b0\u53d1\u73b0<\/p>\n<\/li>\n<\/ul>\n

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                            2018\u5e7410\u670811\u65e5\uff0c\u65b0\u578b6-\u6c28\u57fa6-\u8131\u6c27\u591a\u7cd6\u7c7b\u5206\u5b50\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u80fd\u591f\u6cbb\u7597\u80a5\u80d6<\/p>\n<\/li>\n<\/ul>\n

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                            • \n

                              2018\u5e7410\u670823\u65e5\uff0cdapirolizumab  pegol\u5728\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u7684IIb\u671f\u7814\u7a76\u7ed3\u679c\u516c\u5e03<\/p>\n<\/li>\n<\/ul>\n

                              \u795e\u7ecf\u7c7b\u75be\u75c5<\/span><\/p>\n

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                                2018\u5e7410\u670815\u65e5\uff0c\u9ed8\u514b\u516c\u53f8\u53d1\u8868evobrutinib\u7684\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u6570\u636e<\/p>\n<\/li>\n

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                                2018\u5e7410\u670831\u65e5\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793aBAN-2401\u53ef\u6539\u5584\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u72b6<\/p>\n<\/li>\n<\/ul>\n

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                                  2018\u5e7410\u670819\u65e5\uff0cIPR-166\u80fd\u63d0\u9ad8\u7c7b\u7cbe\u795e\u5206\u88c2\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u8ba4\u77e5\u80fd\u529b<\/p>\n<\/li>\n<\/ul>\n

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                                    2018\u5e7410\u670829\u65e5\uff0cSIM1\u57fa\u56e0\u9644\u8fd1\u7684\u5355\u57fa\u56e0\u4f4d\u70b9\u4e0e\u52c3\u8d77\u529f\u80fd\u969c\u788d\u98ce\u9669\u663e\u8457\u76f8\u5173<\/p>\n<\/li>\n<\/ul>\n

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                                      2018\u5e7410\u670816\u65e5\uff0cDupixent\u5728III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u80fd\u591f\u51cf\u5c0f\u9f3b\u606f\u8089\u5927\u5c0f\u5e76\u7f13\u89e3\u9f3b\u585e\u7a0b\u5ea6<\/p>\n<\/li>\n<\/ul>\n

                                      \u836f\u7269\u6ee5\u7528\u53ca\u4e2d\u6bd2<\/span><\/p>\n

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                                        2018\u5e7410\u670829\u65e5\uff0c\u6cd5\u56fd\u6210\u4e3a\u7b2c\u4e00\u4e2a\u9500\u552ebaclofen\u5236\u5242\u4ee5\u51cf\u5c11\u9152\u7cbe\u6d88\u8d39\u7684\u56fd\u5bb6<\/p>\n<\/li>\n<\/ul>\n

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                                        \u827e\u6ecb\u75c5<\/span><\/strong><\/span>
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                                        2018\u5e7410\u67081\u65e5\uff0c\u8054\u5408\u6297\u4f53\u6291\u5236\u827e\u6ecb\u75c5\u6bd2\u53ca\u5176\u8010\u836f\u6027<\/span><\/p>\n

                                        \u6765\u81ea\u6d1b\u514b\u83f2\u52d2\u5927\u5b66\u548c\u5fb7\u56fd\u79d1\u9686\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u62a5\u9053\u8bf4\uff0c\u901a\u8fc7\u6297\u4f53\u8054\u5408\u7597\u6cd5\u53ef\u4ee5\u5728\u957f\u65f6\u95f4\u5185\u6709\u6548\u7684\u6291\u5236\u6d3b\u8dc3\u671f\u548c\u6f5c\u4f0f\u671fHIV\u611f\u67d3\u8005\u7684\u4f53\u5185\u75c5\u6bd2\u590d\u5236\u3002\u4f7f\u7528\u5355\u4e00\u7684\u6297\u4f53\u6cbb\u7597\uff0c\u4e0e\u4f7f\u7528\u5355\u4e00\u6297\u75c5\u6bd2\u836f\u7269\u7c7b\u4f3c\uff0c\u5747\u4f1a\u5bfc\u81f4\u8010\u836f\u6027\u8fc5\u901f\u53d1\u5c55\u3002\u5728\u4e00\u9879I\u671f\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u7528\u6d4b\u8bd5\u4e86\u4e24\u79cd\u4e2d\u548c\u6297\u4f53\u8054\u7528\u5bf9\u4e24\u7ec4HIV\u9633\u6027\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\uff08ClinicalTrials.gov\u7f16\u53f7NCT02825797\uff09\u3002\u7ed3\u679c\u8868\u660e\uff0c\u8054\u5408\u6cbb\u7597\u53ef\u4ee5\u5728\u957f\u65f6\u95f4\u5185\u51cf\u5c11\u548c\u6291\u5236\u75c5\u6bd2\u6570\u91cf\u3002\u8be5\u7814\u7a76\u56e2\u961f\u603b\u7ed3\u5230\uff0c3BNC117 \u548c10-1074\u4e24\u79cd\u6297HIV-1\u5355\u6297\u7684\u8054\u5408\u4f7f\u7528\uff0c\u80fd\u591f\u5728\u4e0d\u4f7f\u7528\u6297\u75c5\u6bd2\u836f\u7269\u6cbb\u7597\u65f6\uff0c\u5bf9\u6297\u4f53\u7597\u6cd5\u654f\u611f\u60a3\u8005\u4f53\u5185\u7684\u75c5\u6bd2\u5b9e\u73b0\u8f83\u957f\u65f6\u95f4\u7684\u6291\u5236\u3002\u4f46\u540c\u65f6\u4e5f\u8b66\u544a\u8bf4\uff0c\u76ee\u524d\u8fd8\u9700\u8981\u66f4\u5927\u89c4\u6a21\u7684\u7814\u7a76\u6765\u8bc1\u5b9e\u8be5\u7597\u6cd5\u5bf9HIV-1\u75c5\u6bd2\u8840\u75c7\u7684\u7597\u6548\u548c\u5bf9\u8010\u836f\u75c5\u6bd2\u7a81\u53d8\u4f53\u7684\u9650\u5236\u4f5c\u7528\u3002\uff08Mendoza, P. et al. Nature 2018, 561: 479; Bar-On, Y. et al. Nat Med 2018, Advanced publication\uff09\u3002<\/span>
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                                        2018\u5e7410\u670819\u65e5\uff0cST Pharm\u516c\u53f8\u53d1\u73b0\u65b0\u7684HIV\u6574\u5408\u9176\u6291\u5236\u5242<\/span><\/p>\n

                                        ST Pharm\u516c\u53f8\u53d1\u8868\u4e86\u4e00\u7c7b\u5421\u54af\u5e76\u5421\u5576\u7c7b\u5316\u5408\u7269\u4f5c\u4e3aHIV\u6574\u5408\u9176\u6291\u5236\u5242\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597HIV\u611f\u67d3\u3002\u4ee3\u8868\u5316\u5408\u7269\u5728MT-4\u7ec6\u80de\u4e2d\u5bf9HIV-1\uff08IIIB\uff09\u91ce\u751f\u578b\uff08EC50 = 3.23 nM\uff09\u3001NL4-3\u91ce\u751f\u578b\uff08IC50 = 3.6 nM\uff09\u548cHIV-1 raltegravir\u8010\u836f\u7a81\u53d8\u4f534736-2\u30014736-4\u30018070-1\u30018070-2\u548c1556-1\uff08IC50\u5206\u522b\u4e3a1.1\u30013.4\u30010.9\u30013.4\u548c3.4 nM\uff09\u5747\u663e\u793a\u51fa\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u8be5\u5316\u5408\u7269\u5728\u5927\u9f20\u3001\u72ac\u3001\u7334\u548c\u4eba\u809d\u5fae\u7c92\u4f53\u7684\u534a\u8870\u671f\u5206\u522b\u4e3a>145 min\u3001>145 min\u3001133.3 min\u548c135.9 min\u3002\u5bf9\u4eba\u809d\u5fae\u7c92\u4f53\u4e2dCYP1A2\u3001CYP2C9\u3001CYP2D6\u3001CYP3A4\u548cCYP2C19\u7684\u5747\u65e0\u6291\u5236\u6d3b\u6027\uff08IC50\u5206\u522b\u4e3a113.6\u300168.5\u3001101.6\u300192.1\u548c101.6 mcM\uff09\u3002\u5728\u819c\u7247\u94b3\u5b9e\u9a8c\u4e2d\uff0c\u5316\u5408\u7269\u5bf9HEK-293\u7ec6\u80de\u7684hERG\u901a\u9053\u65e0\u660e\u663e\u6291\u5236\uff08IC50 = 66.7 mcM\uff09\u3002\u5316\u5408\u7269\u5728\u96c4\u6027\u5927\u9f20\u4f53\u5185\u7684\u534a\u8870\u671f\u4e3a8.66 h\uff0c\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u4e3a71.8%\u3002\uff08\u8be6\u89c1\u4e13\u5229WO 2018174320\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                        \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                        \u56fe\u4e3a\u4e13\u5229WO 2018174320\u4e2d\u7684\u4ee3\u8868\u5316\u5408\u7269\u7ed3\u6784<\/span><\/p>\n

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                                        \u751f\u7269\u6807\u5fd7\u7269<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670816\u65e5\uff0cADAMTS7\u6216\u53ef\u4f5c\u4e3a2\u578b\u7cd6\u5c3f\u75c5\u65e9\u671f\u5de6\u5ba4\u8212\u5f20\u548c\u6536\u7f29\u529f\u80fd\u969c\u788d\u7684\u4e34\u5e8a\u6307\u6807<\/span><\/p>\n

                                        Tzaneio General Hospital of Piraeus\u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\u7ed3\u679c\uff0c\u8bc4\u4f30\u4e86ADAMTS7\u5bf9\u65e0\u5fc3\u8840\u7ba1\u75be\u75c5\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5fc3\u810f\u91cd\u5851\u7684\u5f71\u54cd\u3002\u5171\u5bf965\u4f8b\u65e0\u5df2\u77e5\u5fc3\u8840\u7ba1\u75be\u75c5\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u60a3\u8005\u5728\u7a7a\u8179\u72b6\u6001\u4e0b\u91c7\u96c6\u8840\u6db2\u6837\u672c\u4ee5\u6d4b\u91cfADAMTS7\u57fa\u51c6\u503c\uff0c\u5e76\u5728\u57fa\u51c6\u72b6\u6001\u548c\u5165\u7ec412\u4e2a\u6708\u540e\u5206\u522b\u8fdb\u884c\u5fc3\u810f\u8d85\u58f0\u68c0\u67e5\u3002ADAMTS7\u7684\u57fa\u51c6\u503c\u5e73\u5747\u6c34\u5e73\u4e3a0.32 pg\/mL\uff0c\u5927\u591a\u6570\u7814\u7a76\u60a3\u8005\uff0890%\uff09\u63a5\u53d7\u4e8c\u7532\u53cc\u80cd\u6cbb\u7597\u3002\u6b64\u5916\uff0c38.7%\u7684\u60a3\u8005\u4f7f\u7528DPP-4\u6291\u5236\u5242\uff0c25.8%\u4f7f\u7528GLP-1\u7c7b\u4f3c\u7269\uff0c12.9%\u4f7f\u7528\u78fa\u9170\u8132\u7c7b\u836f\u7269\uff0c9.7%\u4f7f\u7528SGLT2\u6291\u5236\u5242\uff0c3.2%\u4f7f\u7528\u567b\u5511\u70f7\u4e8c\u916e\u7c7b\u6291\u5236\u5242\uff0c25.8%\u4f7f\u7528\u80f0\u5c9b\u7d20\u3002\u9ad8\u8840\u538b\u548c\u8840\u8102\u5f02\u5e38\u5206\u522b\u5360\u60a3\u8005\u603b\u6570\u768480.6%\u548c61.3%\u3002\u591a\u56e0\u7d20\u56de\u5f52\u5206\u6790\u8868\u660e\uff0c\u5728\u8c03\u6574\u5df2\u5efa\u7acb\u5fc3\u529f\u80fd\u8d85\u58f0\u6307\u6807\u540e\uff0cADAMTS7\u6c34\u5e73\u4e0e\u5de6\u5ba4\u5185\u5f84\uff08LVID\uff09\u5448\u6b63\u76f8\u5173\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0cADAMTS7\u53ef\u80fd\u662f2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u65e9\u671f\u5de6\u5ba4\u8212\u5f20\u548c\u6536\u7f29\u529f\u80fd\u969c\u788d\u7684\u4e00\u4e2a\u6f5c\u5728\u6307\u6807\uff0c\u8be5\u7814\u7a76\u8865\u5145\u4e86ADAMTS7\u6709\u6f5c\u529b\u4f5c\u4e3a\u5fc3\u810f\u91cd\u5851\u751f\u7269\u6807\u5fd7\u7269\u7684\u4f5c\u7528\u3002\uff08Ganotopoulou, A. et al. 54th Annu Meet EurAssoc Study Diabetes (EASD) (Oct 2-5, Berlin) 2018, Abst 1168\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        2018\u5e7410\u67085\u65e5\uff0cC1QBP\u53ef\u7528\u6765\u9884\u6d4b\u95f4\u76ae\u7624\u60a3\u8005\u5316\u7597\u540e\u7684\u751f\u5b58\u671f<\/span><\/p>\n

                                        \u8865\u4f53\u6210\u52061Q\u5b50\u6210\u5206\u7ed3\u5408\u86cb\u767d\uff08\u7ebf\u7c92\u4f53C1QBP\uff09\u53c8\u79f0\u4e3agC1qR\uff0c\u662f\u4e00\u79cd\u591a\u5ba4\u7ed3\u6784\u7ec6\u80de\u86cb\u767d\uff0c\u88ab\u53d1\u73b0\u53ef\u4ee5\u4fc3\u8fdb\u5316\u7597\u8bf1\u5bfc\u7684\u764c\u7ec6\u80de\u51cb\u4ea1\uff0c\u4f46\u5728\u75c5\u6bd2\u611f\u67d3\u8fc7\u7a0b\u4e2d\u4f1a\u5f71\u54cdCD4-T\u7ec6\u80de\u7684\u589e\u6b96\u3002\u6709\u79d1\u5b66\u5bb6\u7814\u7a76\u4e86C1QBP\u5728\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\uff08MPM\uff09\u5316\u7597\u540e\u7684\u8868\u8fbe\u53ca\u5bf9\u751f\u5b58\u671f\u7684\u5f71\u54cd\u3002\u91c7\u7528\u514d\u75ab\u7ec4\u5316\u7684\u65b9\u6cd5\u5171\u68c0\u6d4b\u4e86265\u4f8b\u60a3\u8005\u7684C1QBP\u8868\u8fbe\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u826f\u6027\u7ec4\u7ec7\u548c\u6d3b\u6027\u95f4\u76ae\u7ec6\u80de\u76f8\u6bd4\uff0cC1QBP\u5728\u6240\u6709MPM\u7ec4\u7ec7\u4e2d\u90fd\u8fc7\u8868\u8fbe\u3002\u5728\u63a5\u53d7\u65b0\u8f85\u52a9\u5316\u7597\uff08NAC\uff09\u7684\u4e0a\u76ae\u6837MPM\u60a3\u8005\u4e2d\uff0c\u4e0eC1QBP\u4f4e\u8868\u8fbe\u7684\u60a3\u8005\u76f8\u6bd4\uff0cC1QBP\u7684\u9ad8\u8868\u8fbe\u4e0e\u66f4\u9ad8\u7684\u603b\u751f\u5b58\u671f\uff0825\u4e2a\u6708vs11\u4e2a\u6708\uff09\u76f8\u5173\uff08P = 0.02\uff09\u3002\u6b64\u5916\uff0c\u6ca1\u6709\u63a5\u53d7NAC\u6cbb\u7597\u7684\u60a3\u8005\u7684\u751f\u5b58\u671f\u4e5f\u66f4\u957f\u3002\u591a\u56e0\u7d20\u5206\u6790\u8868\u660e\uff0cC1QBP\u53ef\u4f5c\u4e3a\u9884\u6d4b\u603b\u751f\u5b58\u671f\u7684\u72ec\u7acb\u6027\u9884\u540e\u56e0\u7d20\u3002\u6b64\u5916\uff0cC1QBP\u7684\u8868\u8fbe\u4e0eCD4-T\u7ec6\u80de\u6d78\u6da6\u65e0\u5173\uff0c\u4f46\u6ca1\u6709\u63a5\u53d7NAC\u6cbb\u7597\u7684\u60a3\u8005\u7684C1QBP\u8868\u8fbe\u548cCD4 -T\u7ec6\u80de\u6d78\u6da6\u90fd\u66f4\u9ad8\uff0c\u603b\u751f\u5b58\u671f\u4e5f\u6bd4\u4f4e\u8868\u8fbe\u6216\u4f4e\u6d78\u6da6\u7684\u60a3\u8005\u66f4\u957f\uff08P = 0.001\uff09\u3002\uff08Li, X. et al. 19th World Conf Lung Cancer (Sept 23-26, Toronto) 2018, Abst MA12.07\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        \u80bf\u7624<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670824\u65e5\uff0c\u62dc\u8033\u5236\u836f\u53d1\u73b0\u65b0\u7684CDK9\u6291\u5236\u5242<\/span><\/p>\n

                                        \u62dc\u8033\u516c\u53f8\u53d1\u73b0\u4e86\u4e00\u7c7b\u65b0\u9896\u7684\u5927\u73af\u7c7b\u7ec6\u80de\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u6fc0\u91769\uff08CDK9\uff09\u6291\u5236\u5242\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u75c5\u6bd2\u611f\u67d3\u3002\u4ee3\u8868\u5316\u5408\u7269\u5728\u4f53\u5916\u5b9e\u9a8c\u4e2d\u5bf9PTEFb\u5177\u6709\u4eb2\u548c\u529b\uff08Kd = 7.4 x 10[-11] 1\/s\uff09\u3002\u5728\u57fa\u4e8eTR-FRET\u7684ATP\u7ed3\u5408\u5b9e\u9a8c\u4e2d\uff0c\u5316\u5408\u7269\u80fd\u591f\u6291\u5236\u91cd\u7ec4\u5168\u957fHIS\u6807\u8bb0\u7684\u4ebaCDK9\uff08IC50 = 1.8 nM\uff09\uff0c\u9009\u62e9\u6027\u9ad8\u4e8e\u91cd\u7ec4GST\u6807\u8bb0\u7684\u4ebaCDK2\uff08IC50 = 155 nM\uff0c\u9009\u62e9\u6027\u4e3a 87\u500d\uff09\u3002\u5728Titer-Glo \u8424\u5149\u7ec6\u80de\u6d3b\u6027\u68c0\u6d4b\u4e2d\uff0c\u5316\u5408\u7269\u5bf9\u5c0f\u9f20\u9ed1\u8272\u7d20\u7624\u7ec6\u80deB16-F10\uff0c\u4eba\u7c7b\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u7ec6\u80deMOLM-13\uff0c\u5bab\u9888\u764cHeLa\u7ec6\u80de\uff0c\u591a\u91cd\u8010\u836f\u7684HeLa-MaTu-ADR\u7ec6\u80de\uff0c\u80ba\u764cNCI-H460\u7ec6\u80de\uff0c\u524d\u5217\u817aDU-145\u7ec6\u80de\uff0c\u7ed3\u80a0\u764cCaco-2\u7ec6\u80de\u548c\u5375\u5de2\u764cA2780\u7ec6\u80de\u663e\u793a\u51fa\u6297\u589e\u6b96\u6d3b\u6027\uff08IC50\u5206\u522b\u4e3a1.2\u30012\u30011.2\u30014.4\u30019.2\u30014.5\u30018.4\u548c1.2 nM\uff09\u3002\uff08\u8be6\u89c1\u4e13\u5229WO 2018177889\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                        \n
                                        \n
                                        \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
                                        \n
                                        \n
                                        \n

                                        \u56fe\u4e3a\u4e13\u5229WO 2018177889\u4e2d\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784<\/span><\/p>\n

                                         <\/span><\/p>\n

                                        2018\u5e7410\u670817\u65e5\uff0c\u53f0\u5317\u533b\u79d1\u5927\u5b66\u53d1\u73b0\u65b0\u578bHSP90\u6291\u5236\u5242<\/span><\/p>\n

                                        \u53f0\u5317\u533b\u79d1\u5927\u5b66\u53d1\u73b0\u4e86\u4e00\u7c7b\u65b0\u9896\u7684\u70ed\u4f11\u514b\u86cb\u767d90\uff08HSP90\uff09\u6291\u5236\u5242\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u3002\u4ee3\u8868\u5316\u5408\u7269\u5bf9HSP90\u7684\u6291\u5236\u6d3b\u6027\u4e3aIC50 =110.18 nM\u3002\u5728SRB\u6cd5\u6d4b\u8bd5\u4e2d\uff0c\u5316\u5408\u7269\u5bf9\u4eba\u80ba\u764cA549\u7ec6\u80de\u3001\u7ed3\u80a0\u764cHCT116\u7ec6\u80de\u3001\u809d\u764cHep3B\u7ec6\u80de\u3001\u4e73\u817a\u764cMDA-MB-231\u7ec6\u80de\u548c\u53e3\u8154\u764cKB\u7ec6\u80de\u5177\u6709\u6297\u589e\u6b96\u6d3b\u6027\uff0cGI50\u5206\u522b\u4e3a0.07\u30010.09\u30010.2\u30010.09\u548c0.05 mcM\uff0c\u4e14\u5bf9\u6b63\u5e38HUVEC\u7ec6\u80de\uff08GI50 = 0.87 mcM\uff09\u5177\u6709\u9009\u62e9\u6027\u3002\u5728MTT\u6cd5\u68c0\u6d4b\u4e2d\uff0c\u5316\u5408\u7269\u5bf9\u4eba\u6025\u6027\u65e9\u5e7c\u7c92\u7ec6\u80de\u767d\u8840\u75c5HL-60\u3001\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5MOLT-4\u548c\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5K-562\u7ec6\u80de\u4e5f\u6709\u6297\u589e\u6b96\u6d3b\u6027\uff0cIC50\u5206\u522b\u4e3a0.24\u30010.19\u548c0.13 mcM\u3002\u8be5\u5316\u5408\u7269\u80fd\u591f\u6291\u5236HCT116\u8f7d\u7624\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\uff08\u6bcf\u65e5\u53e3\u670d25\u548c100 mg\/kg\uff0c\u6291\u5236\u7387\u5206\u522b\u4e3a 55.6%\u548c74.3%\uff09\u548c\u80ba\u764cA549\u5f02\u79cd\u79fb\u690d\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\uff08\u9694\u65e5\u53e3\u670d25\u300150\u548c100 mg\/kg\uff0c\u6291\u5236\u7387\u5206\u522b\u4e3a46.7%\u300146.9%\u548c50.9%\uff09\uff0c\u4e14\u6ca1\u6709\u663e\u8457\u7684\u4f53\u91cd\u51cf\u8f7b\u3002\u5c0f\u9f20\u6700\u5927\u8010\u53d7\u5242\u91cf\uff08MTD\uff09\u4e3a\u53e3\u670d250 mg\/kg\uff0c\u534a\u8870\u671f27.7 h\uff0c\u5927\u9f20\u53e3\u670d20 mg\/kg\u7684\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u4e3a25%\u3002\uff08\u8be6\u89c1\u4e13\u5229WO 2018171575\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                        \n
                                        \n
                                        \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
                                        \n
                                        \n
                                        \n

                                        \u56fe\u4e3a\u4e13\u5229WO 2018171575\u4e2d\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784<\/span><\/p>\n

                                         <\/p>\n

                                        2018\u5e7410\u670816\u65e5\uff0c\u6297\u80bf\u7624\u9776\u5411\u6cbb\u7597\u5bfc\u81f4\u7ec6\u80de\u547d\u8fd0\u7684\u8f6c\u53d8<\/span><\/p>\n


                                        <\/span><\/p>\n

                                        \u4f5c\u8005\uff1a\u9ad8\u7ea7\u79d1\u5b66\u7f16\u8f91Anette Breindl<\/p>\n


                                        <\/p>\n

                                        \u4e24\u4e2a\u72ec\u7acb\u7684\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\u4e86\u4e00\u79cd\u9488\u5bf9Hedgehog\u4fe1\u53f7\u901a\u8def\u7684\u6297\u80bf\u7624\u9776\u5411\u6cbb\u7597\u8010\u836f\u6027\u4ea7\u751f\u7684\u65b0\u673a\u5236\u3002<\/p>\n


                                        <\/p>\n

                                        \u6765\u81ea\u7f57\u6c0f\u65d7\u4e0b\u7684\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u548cBelgian Free University of Brussels\u7684\u7814\u7a76\u4eba\u5458\u57282018\u5e7410\u67088\u65e5\u7684\u300a\u81ea\u7136\u300b\u6742\u5fd7\u7f51\u7edc\u7248\u4e0a\u62a5\u9053\u4e86\u5bf9\u6291\u5236Hedgehog\u901a\u8def\u6765\u6cbb\u7597\u57fa\u5e95\u7ec6\u80de\u764c\uff08BCC\uff09\u7684\u9776\u5411\u7597\u6cd5Erivedge\uff08vismodegib\uff1b\u7f57\u6c0f\uff09\u7684\u7814\u7a76\uff0c\u7814\u7a76\u4e2d\u53d1\u73b0\u8be5\u7597\u6cd5\u5bfc\u81f4\u4e00\u5c0f\u90e8\u5206\u80bf\u7624\u7ec6\u80de\u7684\u547d\u8fd0\u53d1\u751f\u4e86\u67d0\u4e9b\u8f6c\u53d8\uff0c\u80fd\u591f\u4fdd\u62a4\u5b83\u4eec\u514d\u53d7\u836f\u7269\u7684\u4f5c\u7528\u3002<\/p>\n


                                        <\/p>\n

                                        \u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u5206\u5b50\u80bf\u7624\u5b66VP\uff0c\u79d1\u5b66\u5bb6Frederic de Sauvage\u544a\u8bc9BioWorld Science\uff1a\u201c\u6211\u4eec\u5728\u7814\u7a76\u4e2d\u53d1\u73b0\u4e00\u4e9b\u80bf\u7624\u7ec6\u80de\u6210\u529f\u5730\u907f\u5f00\u4e86\u836f\u7269\u7684\u4f5c\u7528\uff0c\u5e76\u4ee5\u4e00\u79cd\u4e0d\u540c\u7684\u8eab\u4efd\u201c\u9690\u85cf\u201d\u8d77\u6765\u3002\u201d\u4ed6\u8865\u5145\u8bf4\uff1a\u201c\u8fd9\u662f\u4e00\u79cd\u5168\u65b0\u7684\u673a\u5236\uff0c\u53ef\u80fd\u5e7f\u6cdb\u7684\u5b58\u5728\u4e8e\u5176\u4ed6\u7c7b\u578b\u7684\u764c\u75c7\uff0c\u8fd9\u662f\u6211\u4eec\u6ca1\u6709\u9884\u6599\u5230\u7684\u3002\u5f53\u6570\u636e\u8ba9\u4f60\u4ee5\u4e00\u79cd\u5168\u65b0\u7684\u65b9\u5f0f\u601d\u8003\u95ee\u9898\u65f6\uff0c\u4ee4\u4eba\u975e\u5e38\u5174\u594b\u3002\u201d<\/p>\n


                                        <\/p>\n

                                        \u547d\u8fd0\u7684\u8f6c\u53d8\u867d\u7136\u4f7f\u764c\u7ec6\u80de\u5bf9Hedgehog\u6291\u5236\u5242\u4e0d\u518d\u654f\u611f\uff0c\u4f46\u4e5f\u66b4\u9732\u4e86\u65b0\u7684\u5f31\u70b9\u3002\u4e24\u7ec4\u7814\u7a76\u4eba\u5458\u90fd\u6307\u51fa\uff0c\u8054\u5408\u4f7f\u7528Everidge\u548cWnt\u6291\u5236\u5242\u53ef\u4ee5\u5b8c\u5168\u6e05\u9664\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684BCC\u3002BCC\u662f\u6240\u6709\u764c\u75c7\u4e2d\u6700\u5e38\u89c1\u7684\u4e00\u79cd\uff0c\u4f46\u4e0e\u9ed1\u8272\u7d20\u7624\u4e0d\u540c\u7684\u662f\uff0cBCC\u7684\u8f6c\u79fb\u51e0\u7387\u975e\u5e38\u4f4e\uff0c\u4f46\u590d\u53d1\u5374\u66f4\u4e3a\u9891\u7e41\u3002\u5728\u6240\u6709\u7684\u764c\u75c7\u7c7b\u578b\u4e2d\uff0c\u8010\u836f\u548c\u590d\u53d1\u90fd\u662f\u4e00\u4e2a\u666e\u904d\u7684\u95ee\u9898\u3002<\/p>\n


                                        <\/p>\n

                                        Frederic de Sauvage\u8bf4\uff1a\u201c\u7531\u4e8e\u76ae\u80a4\u80bf\u7624\u7684\u53ef\u53ca\u6027\uff0cBCC\u63d0\u4f9b\u4e86\u4e00\u79cd\u5b9e\u4f53\u80bf\u7624\u4e2d\u201c\u72ec\u7279\u7684\u673a\u4f1a\u201d\u6765\u7814\u7a76\u8fd9\u4e9b\u73b0\u8c61\u3002\u4ed6\u8865\u5145\u8bf4\uff1a\u201c\u8fd9\u79cd\u9003\u907f\u9776\u5411\u6cbb\u7597\u7684\u673a\u5236\u53ef\u80fd\u6d89\u53ca\u5230\u5176\u4ed6\u56e0\u7d20\uff0c\u53ef\u80fd\u5e2e\u52a9\u6211\u4eec\u5f00\u53d1\u5bf9\u5176\u4ed6\u764c\u75c7\u4ea7\u751f\u66f4\u5b8c\u5168\u54cd\u5e94\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u201d<\/p>\n


                                        <\/p>\n

                                        \u5728\u4ed6\u4eec\u7684\u5de5\u4f5c\u4e2d\uff0c\u7814\u7a76\u5c0f\u7ec4\u9996\u5148\u8bd5\u56fe\u4e86\u89e3Everidge\u7597\u6cd5\u9664\u53bb\u6291\u5236Hedgehog\u901a\u8def\u4ee5\u5916\u7684\u4f5c\u7528\u548c\u5f71\u54cd\u3002\u7814\u7a76\u53d1\u73b0Everidge\u7684\u4e3b\u8981\u4f5c\u7528\u4e0d\u662f\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u3002\u76f8\u53cd\uff0c\u5b83\u4f3c\u4e4e\u4fc3\u8fdb\u4e86\u80bf\u7624\u7ec6\u80de\u5411\u6210\u719f\u7ec6\u80de\u7684\u5206\u5316\u3002\u7136\u800c\uff0c\u6709\u4e9b\u7ec6\u80de\u5bf9\u836f\u7269\u7684\u53cd\u5e94\u4e0d\u540c\u3002\u4ed6\u4eec\u6ca1\u6709\u5206\u5316\u6210\u6210\u719f\u7ec6\u80de\uff0c\u800c\u662f\u8f6c\u53d8\u6210\u4e00\u79cd\u7c7b\u4f3c\u4e8e\u7684\u72b6\u6001\uff0c\u5176\u7279\u5f81\u662fLGR5\u86cb\u767d\u7684\u8868\u8fbe\uff0cLGR5\u662fWnt\u4fe1\u53f7\u901a\u8def\u7684\u4e00\u4e2a\u7ec4\u6210\u90e8\u5206\uff0c\u662f\u4e00\u79cd\u5728\u80a0\u9053\u4e2d\u8868\u8fbe\u7684\u4e0e\u7ed3\u76f4\u80a0\u764c\u76f8\u5173\u7684\u86cb\u767d\u3002 \u7136\u800c\uff0cBCC\u7ec6\u80de\u5411\u4e0a\u8ff0\u7684\u8f6c\u5316\u53ea\u53d1\u751f\u5728\u836f\u7269\u6cbb\u7597\u671f\u95f4\u3002\u5f53\u505c\u6b62\u6cbb\u7597\u540e\uff0c\u8fd9\u4e9b\u7ec6\u80de\u53c8\u6062\u590d\u4e86\u80bf\u7624\u7ec6\u80de\u8eab\u4efd\u800c\u91cd\u65b0\u751f\u957f\u3002\u968f\u540e\uff0c\u4e24\u9879\u7814\u7a76\u90fd\u8bc1\u660e\u4e86Hedgehog\u548c\u4e0d\u540c\u7684Wnt\u6291\u5236\u5242\u7684\u8054\u5408\u6cbb\u7597\u53ef\u4ee5\u963b\u6b62\u80bf\u7624\u7ec6\u80de\u5411\u7684\u8f6c\u5316\uff0c\u51cf\u5c11\u80bf\u7624\u8d1f\u8377\u751a\u81f3\u5b8c\u5168\u6e05\u9664\u80bf\u7624\u3002<\/p>\n


                                        <\/p>\n

                                        \u4f5c\u8005\u8bba\u6587Cedric Blanpain\u662fFree University of Brussels\u7684\u6559\u6388\uff0c\u540c\u65f6\u4e5f\u662f\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u7684\u987e\u95ee\uff0c\u4ed6\u5728\u4e00\u4efd\u4e8b\u5148\u51c6\u5907\u7684\u58f0\u660e\u4e2d\u8bf4\u5230\uff1a\u201c\u8fd9\u662f\u9996\u6b21\u53d1\u73b0\u4e00\u79cd\u7531FDA\u6279\u51c6\u7684\u5b9e\u4f53\u7624\u6cbb\u7597\u836f\u7269\u80fd\u591f\u901a\u8fc7\u8bf1\u5bfc\u5206\u5316\u8fdb\u800c\u5bfc\u81f4\u80bf\u7624\u7684\u590d\u53d1\u201d\u3002\u8bf1\u5bfc\u5206\u5316\u662f\u76ee\u524d\u6025\u6027\u65e9\u5e7c\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6cd5\uff0c\u540c\u65f6\u4e5f\u6b63\u5728\u5176\u4ed6\u7c7b\u578b\u7684\u767d\u8840\u75c5\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u548c\u5176\u4ed6\u5b9e\u4f53\u7624\u4e2d\u8fdb\u884c\u7814\u7a76\uff08Biehs, B. et al. Nature 2018, Advanced publication; Sanchez-Danes, A. et al. Nature 2018, Advanced publication\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                        \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                        \u56fe\u4e3avismodegib\u7ed3\u6784<\/span><\/p>\n

                                         <\/p>\n

                                        \u80bf\u7624\u514d\u75ab\u6cbb\u7597<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u67081\u65e5\uff0c\u53cc\u7279\u5f02\u6027\u951a\u5b9a\u7684\u7ec6\u80de\u6bd2\u6fc0\u6d3b\u56e0\u5b50\u6297\u4f53\u80fd\u591f\u8bf1\u5bfc\u5375\u5de2\u764c\u7ec6\u80de\u6b7b\u4ea1<\/span><\/p>\n

                                        \u4f7f\u7528\u6297\u5375\u5de2\u764c\u5bcc\u96c6\u53d7\u4f53\u7684\u6297\u4f53\u6765\u9009\u62e9\u6027\u548c\u9776\u5411\u6027\u7684\u6d88\u9664\u5375\u5de2\u764c\u7ec6\u80de\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e00\u76f4\u65e0\u6cd5\u53d6\u5f97\u8fdb\u5c55\uff0c\u5375\u5de2\u764c\u4ecd\u7136\u662f\u6700\u81f4\u547d\u7684\u5987\u79d1\u764c\u75c7\uff0c\u6ca1\u6709\u7279\u522b\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u5728\u6700\u8fd1\u53d1\u8868\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d\uff0c\u6765\u81ea\u5f17\u5409\u5c3c\u4e9a\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u4e86\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u7684\u590d\u5408\u65b9\u6cd5\uff0c\u57fa\u4e8e\u4e00\u79cd\u53cc\u7279\u5f02\u6027\u951a\u5b9a\u7684\u7ec6\u80de\u6bd2\u6027\u6fc0\u6d3b\u56e0\u5b50\uff08BaCa\uff09\u6297\u4f53\u6765\u9776\u5411\u5375\u5de2\u764c\u7ec6\u80de\u3002\u8be5\u6297\u4f53\u53ef\u540c\u65f6\u7279\u5f02\u6027\u7684\u9776\u5411\u53f6\u9178\u53d7\u4f53\uff08FR-alpha\uff09\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53\u8d85\u5bb6\u65cf\u6210\u545810B\uff08TNFRSF10B\uff0c\u4e5f\u88ab\u79f0\u4e3a\u6b7b\u4ea1\u53d7\u4f535\uff09\uff0c\u540c\u65f6\u5f15\u8d77\u201c\u987a\u5f0f\u201d\u548c\u201c\u53cd\u5f0f\u201d\u7684\u7ec6\u80de\u6bd2\u6027\u3002\u8be5\u6297\u4f53\u9488\u5bf9\u8868\u8fbeFR-alpha\u7684\u5375\u5de2\u764c\u7ec6\u80de\u80fd\u591f\u6291\u5236TNFRSF10B\u4ecb\u5bfc\u7684\u51cb\u4ea1\u6fc0\u6d3b\u3002\u53cc\u9776\u5411FR-alpha\u548cTNFRSF10B\u7684\u7b56\u7565\u53ef\u4ee5\u6d88\u9664\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u6bd2\u6027\u4f9d\u8d56\u6027\uff0c\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002\u6570\u636e\u663e\u793a\uff0c\u9776\u5411FR-alpha\u4f5c\u4e3a\u4e3b\u8981\u7684\u4f5c\u7528\u7b56\u7565\uff0c\u80fd\u591f\u7ef4\u6301\u9ad8\u6c34\u5e73\u7684\u80bf\u7624\u7279\u5f02\u6027\u51cb\u4ea1\uff0c\u800c\u4f53\u5185\u6fc0\u52a8TNFRSF10B\u4fe1\u53f7\u9700\u8981Fcgamma-RIIB\u7684\u76f8\u4e92\u4f5c\u7528\u3002BaCa\u6297\u4f53\u6cbb\u7597\u7b56\u7565\u4f18\u4e8e\u4ee5\u5f80\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684TNFRSF10B\u6fc0\u6d3b\u7b56\u7565\u548cApo2L\/TRAIL\u8054\u5408\u7597\u6cd5\u3002\u672c\u7814\u7a76\u8bc1\u5b9e\u4e86\u4e0a\u8ff0\u7b56\u7565\u7528\u4ee5\u6cbb\u7597\u5375\u5de2\u764c\u7684\u53ef\u884c\u6027\u3002\u6b64\u5916\uff0c\u8be5\u7b56\u7565\u4e5f\u6709\u671b\u7528\u4e8e\u5176\u4ed6\u7c7b\u578b\u764c\u75c7\u7684\u6cbb\u7597\u3002\uff08ShivanFDge, G. et al. Cancer 2018, 34(2): 331\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        2018\u5e7410\u670822\u65e5\uff0cGITR\u6fc0\u52a8\u5242MEDI-1873\u7684\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u6570\u636e\u5728ESMO\u4f1a\u8bae\u4e0a\u516c\u5e03<\/span><\/p>\n

                                        \u7cd6\u76ae\u8d28\u6fc0\u7d20\u8bf1\u5bfc\u7684\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u76f8\u5173\u86cb\u767d\uff08GITR\uff09\u662f\u6fc0\u6d3b\u7684\u6548\u5e94T\u7ec6\u80de\u548c\u8c03\u8282\u6027T\u7ec6\u80de\u4e0a\u7684\u5171\u523a\u6fc0\u4fe1\u53f7\u53d7\u4f53\u3002MedImmune\u516c\u53f8\u7684MEDI-1873\uff08efgivanermin alfa\uff09\u662f\u4e00\u79cd\u65b0\u578b\u7684GITR-ligand IgG1\u6fc0\u52a8\u5242\u878d\u5408\u86cb\u767d\uff0c\u80fd\u591f\u4e0eCD4+\u3001CD8+\u6548\u5e94T\u7ec6\u80de\u548c\u8c03\u8282\u6027T\u7ec6\u80de\u4e0a\u7684GITR\u7ed3\u5408\u3002\u5728\u6155\u5c3c\u9ed1\u53ec\u5f00\u7684\u6b27\u6d32\u80bf\u7624\u533b\u5b66\u534f\u4f1a\u4f1a\u8bae\u4e0a\uff0c\u8be5\u516c\u53f8\u516c\u5e03\u4e86\u8be5\u836f\u9488\u5bf9\u5b9e\u4f53\u80bf\u7624\u60a3\u8005\u7684\u9996\u6b21\u4eba\u4f53I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff08ClinicalTrials.gov\u7f16\u53f7NCT02583165\uff09\u3002\u672c\u7814\u7a76\u7684\u5242\u91cf\u9012\u589e\u9636\u6bb5\u8bc4\u4f30\u4e86\u60a3\u8005\u5728\u6700\u4f4e\u5242\u91cf\uff081.5\u548c3mg\uff09\uff0c\u548c\u91c7\u75283+3\u5242\u91cf\u9012\u589e\u65b9\u6848\u7684\u51716\u7ec4\u60a3\u8005\uff0c\u5242\u91cf\u8303\u56f4\u4ece7.5mg\u5230750mg\u7684\u5b89\u5168\u6027\u6307\u6807\uff08\u6bcf\u4e24\u5468\u7ed9\u836f\u4e00\u6b21\uff09\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u5b89\u5168\u6027\u548c\u5242\u91cf\u9650\u5236\u6bd2\u6027\uff08DLTs\uff09\uff0c\u5171\u670940\u4f8b\u60a3\u8005\u5165\u7ec4\u3002\u5bf9\u4e8e\u60a3\u6709\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u6216\u7ed3\u76f4\u80a0\u764c\u7684\u60a3\u8005\u8fd8\u63a5\u53d7\u4e8675\u6216250mg\u7684\u6cbb\u7597\uff0c\u4ee5\u8bc4\u4f30\u5176\u836f\u6548\u5b66\u53c2\u6570\u3002\u622a\u6b622018\u5e748\u6708\uff0c\u5165\u7ec4\u60a3\u8005\u4e2d50%\u60a3\u6709\u7ed3\u76f4\u80a0\u764c\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a10.65\u4e2a\u6708\uff0c\u5927\u591a\u6570\u60a3\u8005\u5df2\u63a5\u53d7\u8fc7\u4e24\u5230\u4e09\u6b21\u6cbb\u7597\u3002\u5171\u67093\u7c7bDLTs\u62a5\u544a\uff0c\u5206\u522b\u4e3a3\u7ea7\u52a0\u91cd\u7684\u80bf\u7624\u75bc\u75db\uff0c3\u7ea7\u7684\u6076\u5fc3\u5455\u5410\u548c3\u7ea7\u7684\u975eST\u6bb5\u62ac\u9ad8\u5fc3\u808c\u6897\u6b7b\u3002\u8be5\u7814\u7a76\u672a\u8fbe\u5230\u6700\u5927\u8010\u53d7\u5242\u91cf\u3002\u5176\u4e2d82.5%\u7684\u60a3\u8005\u51fa\u73b0\u8fc7\u5404\u79cd\u7ea7\u522b\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u6700\u5e38\u89c1\u7684\u662f\u5934\u75db\uff0825%\uff09\u3001\u8f93\u6db2\u76f8\u5173\u53cd\u5e94\uff0817.5%\uff09\u3001\u75b2\u52b3\uff0817.5%\uff09\u548c\u538c\u98df\uff0817.5%\uff09\u30023-4\u7ea7\u7684\u4e0d\u826f\u4e8b\u4ef6\u5728250mg\u4ee5\u4e0a\u5242\u91cf\u4e2d\u6700\u4e3a\u5e38\u89c1\u3002\u6700\u597d\u7684\u6cbb\u7597\u6548\u679c\u662f\u75c5\u60c5\u7a33\u5b9a\uff0c\u7ea6\u572842.5%\u7684\u60a3\u8005\u4e2d\u51fa\u73b0\uff0c\u5305\u62ec1\u4f8b\u672a\u8bc1\u5b9e\u7684\u90e8\u5206\u7f13\u89e3\uff0c20%\u7684\u60a3\u8005\u75c5\u60c5\u7a33\u5b9a\u8d85\u8fc724\u5468\u3002\u8be5\u836f\u7684\u836f\u7269\u52a8\u529b\u5b66\u53c2\u6570\u662f\u7ebf\u6027\u7684\uff1b\u534a\u8870\u671f\u7ea6\u4e3a2\u5929\u3002\u836f\u6548\u5b66\u7814\u7a76\u8bc1\u5b9e\u4e86\u8be5\u836f\u5728\u9776\u4f4d\u4e0a\u7684\u7ed3\u5408\u3002\u4e0e\u57fa\u51c6\u503c\u76f8\u6bd4\uff0c\u8be5\u7597\u6cd5\u5f15\u8d77\u4e86CD4+GITR+\u6548\u5e94\u8bb0\u5fc6\u6027T\u7ec6\u80de\u6570\u91cf\u7684\u51cf\u5c11\uff0c\u540c\u65f6GITR+\u7ec6\u80de\u6570\u91cf\u4e5f\u53d1\u751f\u4e86\u53d8\u5316\uff08Denlinger, C.S. 42nd Eur Soc Med Oncol (ESMO) Congr (Oct 19-23, Munich) 2018, Abst 1154P\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        2018\u5e7410\u670819\u65e5\uff0cMM-121\u6cbb\u7597NSCLC\u65e0\u6548\uff0cMerrimack\u516c\u53f8\u7ec8\u6b62\u4e86\u540d\u4e3aSHERLOC\u7684\u4e34\u5e8a\u7814\u7a76<\/span><\/p>\n

                                        Merrimack Pharmaceuticals\u516c\u53f8\u5ba3\u5e03\u7ec8\u6b62\u4e86\u4e00\u9879\u540d\u4e3aSHERLOC\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8fd9\u9879\u7814\u7a76\u62df\u5728Heregulin\u9633\u6027\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u4e2d\u8bc4\u4f30MM-121\uff08seribantumab\uff09\u4e0e\u591a\u897f\u4ed6\u8d5b\u8054\u5408\u4f7f\u7528\u7684\u7597\u6548\u3002\u8fd9\u9879\u5168\u7403\u6027\u7684\u968f\u673a\u3001\u57fa\u4e8e\u751f\u7269\u6807\u5fd7\u7269\u9009\u62e9\u7684\u5f00\u653e\u6807\u7b7e\u7684II\u671f\u8bd5\u9a8c\u5171\u7eb3\u5165\u4e86109\u540dNSCLC\u60a3\u8005\u3002\u7ec8\u6b62\u8bd5\u9a8c\u7684\u51b3\u5b9a\u662f\u5728\u4e0e\u72ec\u7acb\u6570\u636e\u5b89\u5168\u76d1\u6d4b\u59d4\u5458\u4f1a\u534f\u5546\u540e\u505a\u51fa\u7684\u3002\u8be5\u59d4\u5458\u4f1a\u5728\u5168\u90e8\u7814\u7a76\u8fdb\u884c\u523075%\u7684\u65f6\u5019\u8fdb\u884c\u4e86\u4e00\u6b21\u4e34\u65f6\u5206\u6790\u3002\u8fd9\u9879\u5206\u6790\u5171\u6d89\u53ca\u603b\u8ba188%\uff0867\/76\uff09\u7684\u4e34\u5e8a\u4e8b\u4ef6\uff0c\u867d\u7136\u5b89\u5168\u6027\u6570\u636e\u4e0e\u5148\u524d\u7684\u62a5\u9053\u4e00\u81f4\uff0c\u4f46\u6570\u636e\u8868\u660e\uff0c\u6dfb\u52a0MM-121\u7684\u8054\u5408\u7597\u6cd5\u76f8\u6bd4\u4e8e\u591a\u897f\u4ed6\u8d5b\u5355\u836f\u7597\u6cd5\uff0c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u5e76\u6ca1\u6709\u663e\u8457\u6027\u6539\u5584\uff0c\u6545\u51b3\u5b9a\u7ec8\u6b62\u7814\u7a76\u3002Merrimack\u6b63\u5728\u5bf9\u5176\u5019\u9009\u836f\u7269\u7ba1\u7ebf\u8fdb\u884c\u8003\u5bdf\uff0c\u5e76\u5c06\u8bc4\u4f30\u8fd9\u4e9b\u7ed3\u679c\u5bf9\u7ee7\u7eed\u5f00\u53d1MM-121\u7684\u5f71\u54cd\u3002\u76ee\u524d\uff0cMM-121\u540c\u65f6\u5728\u4e00\u9879\u540d\u4e3aSHERBOC\u7684II\u671f\u7814\u7a76\u4e2d\u8bc4\u4f30\u4e0efulvestrant\u8054\u7528\u6cbb\u7597heregulin\u9633\u6027\uff0c\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff0cHER2\u9634\u6027\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002\uff08ClinicalTrials.gov\u7f16\u53f7NCT03241810\uff09\u3002\uff08Merrimack Pharmaceuticals\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        2018\u5e7410\u670831\u65e5\uff0cFDA\u6279\u51c6Keytruda\u4e0e\u5316\u7597\u8054\u5408\u7528\u4e8e\u4e00\u7ebf\u8f6c\u79fb\u6027\u9cde\u72b6NSCLC\u7684\u6cbb\u7597<\/span><\/p>\n

                                        FDA\u5df2\u6279\u51c6\u9ed8\u514b\u516c\u53f8\u7684PD-1\u7597\u6cd5\u836f\u7269Keytruda\uff08pembrolizumab\uff09\u4e0e\u5361\u94c2\u3001\u7d2b\u6749\u9187\u6216\u767d\u86cb\u767d\u7ed3\u5408\u7d2b\u6749\u9187\u8054\u5408\u4f7f\u7528\uff0c\u7528\u4e8e\u8f6c\u79fb\u6027\u9cde\u72b6NSCLC\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u6b64\u6b21\u6279\u51c6\u57fa\u4e8e\u4e00\u9879\u540d\u4e3aKEYNOTE-407\u7684\u7814\u7a76\u6570\u636e\uff0c\u8fd9\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u7684\u6709\u5b89\u6170\u5242\u5bf9\u7167\u7684\u4e34\u5e8a\u7814\u7a76\uff08ClinicalTrials.gov\u7f16\u53f7NCT02775435\uff09\u3002\u672c\u7814\u7a76\u7684\u4e3b\u8981\u5165\u7ec4\u6807\u51c6\u4e3a\u672a\u5bf9\u8f6c\u79fb\u6027\u75be\u75c5\u8fdb\u884c\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff0c\u4e14\u65e0\u5173PD-L1\u7684\u8868\u8fbe\u72b6\u6001\u3002\u6570\u636e\u663e\u793apemrolizumab\u8054\u5408\u5361\u94c2\u3001\u7d2b\u6749\u9187\u6216\u767d\u86cb\u767d\u7ed3\u5408\u7d2b\u6749\u9187\uff0c\u5747\u663e\u8457\u63d0\u9ad8\u4e86\u603b\u4f53\u751f\u5b58\u7387\uff0c\u6bd4\u5355\u72ec\u5316\u7597\u964d\u4f4e\u4e8636%\u7684\u6b7b\u4ea1\u98ce\u9669\u3002\u4e0e\u968f\u673a\u9009\u62e9\u5b89\u6170\u5242\u548c\u5316\u7597\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u968f\u673a\u8054\u5408\u7597\u6cd5\u7ec4\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u548c\u5ba2\u89c2\u53cd\u5e94\u7387\u4e5f\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u6539\u5584\u300215%\u7684\u60a3\u8005\u56e0\u4e0d\u826f\u53cd\u5e94\u800c\u505c\u7528pembrolizumab\uff0c\u4f46\u6ca1\u6709\u5355\u4e00\u7c7b\u578b\u7684\u4e0d\u826f\u53cd\u5e94\u5360\u5927\u591a\u6570\u300243%\u7684\u60a3\u8005\u51fa\u73b0\u5bfc\u81f4\u7528\u836f\u4e2d\u65ad\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u6700\u5e38\u89c1\u7684\u662f\u8840\u5c0f\u677f\u51cf\u5c11\uff0820%\uff09\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0811%\uff09\uff0c\u8d2b\u8840\uff086%\uff09\uff0c\u865a\u5f31\uff082%\uff09\u548c\u8179\u6cfb\uff082%\uff09\u3002\u6700\u5e38\u89c1\u7684\uff08>= 2%\uff09\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u662f\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff086%\uff09\u3001\u80ba\u708e\uff086%\uff09\u548c\u5c3f\u8def\u611f\u67d3\uff083%\uff09\u3002\u8054\u5408\u7597\u6cd5\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08>= 20%\uff09\u4e3b\u8981\u4e3a\u75b2\u52b3\/\u865a\u5f31\u3001\u6076\u5fc3\u3001\u4fbf\u79d8\u3001\u8179\u6cfb\u3001\u98df\u6b32\u51cf\u9000\u3001\u76ae\u75b9\u3001\u5455\u5410\u3001\u54b3\u55fd\u3001\u547c\u5438\u56f0\u96be\u3001\u53d1\u70ed\u3001\u8131\u53d1\u548c\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\u3002\u968f\u7740\u8be5\u9002\u5e94\u75c7\u7684\u83b7\u6279\uff0c\u6240\u6709\u5408\u9002\u7684\u8f6c\u79fb\u6027\u9cde\u72b6\u548c\u975e\u9cde\u72b6\u7684NSCLC\u60a3\u8005\uff0c\u4ee5\u53ca\u4e0d\u5b58\u5728EGFR\u6216ALK\u7a81\u53d8\u7684\u60a3\u8005\uff0c\u5c06\u90fd\u6709\u8d44\u683c\u4f7f\u7528\u4ee5keytruda\u4e3a\u57fa\u7840\u7684\u65b9\u6848\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u3002\uff08\u9ed8\u514b\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        \u5fc3\u8840\u7ba1\u75be\u75c5<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670810\u65e5\uff0c\u6297\u80bf\u7624\u836f\u7269\u6216\u53ef\u88ab\u7528\u4e8e\u6cbb\u7597\u708e\u75c7<\/span><\/p>\n


                                        <\/span><\/p>\n

                                        \u4f5c\u8005\uff1a\u7279\u7ea6\u64b0\u7a3f\u4ebaJohn Fox<\/p>\n


                                        <\/p>\n

                                        \u7f8e\u56fd\u7684\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u73b0\u6709\u7684\u9776\u5411E3\u8fde\u63a5\u9176\u7684\u6297\u80bf\u7624\u836f\u7269\u53ef\u4ee5\u88ab\u91cd\u65b0\u7528\u4e8e\u6cbb\u7597\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u8840\u7ba1\u708e\u75c7\u3002E3\u8fde\u63a5\u9176\u4e0eGPCRs\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u6291\u5236\u6cdb\u7d20\u5316\uff0c\u6cdb\u7d20\u5316\u662f\u4e00\u4e2a\u89e6\u53d1\u81ea\u566c\u548c\u6eb6\u9176\u4f53\u964d\u89e3\u7684\u8fc7\u7a0b\u3002\u8fd9\u9879\u5de5\u4f5c\u5bf9GPCRs\uff08\u83b7\u6279\u836f\u7269\u4e2d\u6700\u5e38\u89c1\u7684\u9776\u6807\uff09\u548c\u6cdb\u7d20\u5316\u529f\u80fd\u63d0\u4f9b\u4e86\u65b0\u7684\u89c1\u89e3\u3002GPCRs\u662f\u4e00\u79cd\u5e7f\u6cdb\u8868\u8fbe\u7684\u8de8\u819c\u7ec6\u80de\u4fe1\u53f7\u53d7\u4f53\u5bb6\u65cf\uff0c\u5728\u5305\u62ec\u8840\u7ba1\u708e\u75c7\u5728\u5185\u7684\u5404\u79cd\u751f\u7406\u8fc7\u7a0b\u4e2d\u5747\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002GPCR\u4fe1\u53f7\u529f\u80fd\u969c\u788d\u4e0e\u591a\u79cd\u75be\u75c5\u6709\u5173\uff0c\u8be5\u53d7\u4f53\u662f\u76ee\u524d\u6279\u51c6\u836f\u7269\u6570\u91cf\u6700\u591a\u7684\u53d7\u4f53\u5bb6\u65cf\u3002<\/p>\n


                                        <\/p>\n

                                        \u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u533b\u5b66\u9662\u7684\u836f\u7406\u5b66\u6559\u6388\uff0c\u6b64\u9879\u7814\u7a76\u7684\u7275\u5934\u4ebaJoAnn Trejo\u8bf4\uff1a\u201c\u76ee\u524d\u6240\u6279\u51c6\u7684\u6240\u6709\u836f\u7269\u4e2d\uff0c\u5927\u7ea6\u670934%\u662f\u9488\u5bf9GPCRs\u7684\u3002\u201d\u8fd9\u4e9b\u836f\u7269\u53ef\u4ee5\u6cbb\u7597\u591a\u79cd\u75be\u75c5\uff0c\u5305\u62ec\u201c\u8fc7\u654f\u3001\u54ee\u5598\u3001\u5fc3\u810f\u75c5\u3001\u708e\u75c7\u3001\u795e\u7ecf\u529f\u80fd\u969c\u788d\u3001\u8840\u6813\u548c\u708e\u75c7\uff0c\u800c\u5176\u4e2d\u4e00\u4e9b\u75be\u75c5\u4ecd\u9700\u8981\u5bfb\u627e\u66f4\u597d\u7684\u6cbb\u7597\u65b9\u6848\u3002\u201d\u7136\u800c\uff0c\u5c3d\u7ba1\u9776\u5411GCPR\u7684\u836f\u7269\u975e\u5e38\u6709\u7528\uff0c\u4f46\u4eba\u4eec\u5bf9\u8fd9\u7c7b\u53d7\u4f53\u7684\u7ed3\u6784\u3001\u529f\u80fd\u548c\u4f5c\u7528\u673a\u5236\u7684\u4e86\u89e3\u4ecd\u5341\u5206\u6709\u9650\u3002<\/p>\n


                                        <\/p>\n

                                        \u5728\u8fd9\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0cTrejo\u9886\u5bfc\u7684\u56e2\u961f\u63ed\u793a\u4e86\u7ec6\u80de\u5229\u7528GPCRs\u548cE3\u8fde\u63a5\u9176\u6765\u63a7\u5236\u708e\u75c7\u7684\u65b0\u65b9\u6cd5\u3002\u8fd9\u4e00\u53d1\u73b0\u53d1\u8868\u57282018\u5e749\u670818\u65e5\u7684\u300a Reports\u300b\u4e0a\uff0c\u5b83\u63ed\u793a\u4e86\u4e00\u4e9b\u73b0\u6709\u7684\u6297\u764c\u836f\u7269\u53ef\u4ee5\u6291\u5236\u7ec6\u80de\u5e9f\u7269\u5904\u7406\u7cfb\u7edf\u4e2dE3\u8fde\u63a5\u9176\u7684\u6d3b\u6027\uff0c\u901a\u8fc7\u4f5c\u7528\u4e8e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u4e2d\u7684\u52a8\u8109\u963b\u585e\u6591\u5757\u6765\u6cbb\u7597\u8840\u7ba1\u708e\u75c7\u3002<\/p>\n


                                        <\/p>\n

                                        \u5f53\u914d\u4f53\u4e0e\u7ec6\u80de\u819c\u80de\u5916\u7684GPCR\u7ed3\u5408\u65f6\uff0c\u5176\u6784\u8c61\u53d1\u751f\u53d8\u5316\u3002\u968f\u540e\u7ec6\u80de\u5185\u7684G\u86cb\u767d\u63a5\u5728\u65b0\u6784\u8c61\u7684GPCR\u4e0a\uff0c\u89e6\u53d1\u4e00\u7cfb\u5217\u4e0b\u6e38\u7684\u7ea7\u8054\u4fe1\u53f7\uff0c\u8fd9\u4e9bG\u86cb\u767d\u4f1a\u6839\u636e\u80de\u5185\u548c\u80de\u5916\u7684\u523a\u6fc0\u7c7b\u578b\u800c\u53d1\u751f\u53d8\u5316\u3002\u7814\u7a76\u4eba\u5458\u5c06\u91cd\u70b9\u653e\u5728\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u4e0a\uff0c\u7814\u7a76\u4e86GPCR\u529f\u80fd\u5982\u4f55\u53d7\u5230\u6cdb\u7d20\u5316\u7684\u5f71\u54cd\u3002\u6cdb\u7d20\u5316\uff0c\u5373\u9176\u901a\u8fc7\u4e00\u79cd\u79f0\u4e3a\u6cdb\u7d20\u7684\u5c0f\u5206\u5b50\u6807\u8bb0\u86cb\u767d\u8d28\uff0c\u5c06\u5176\u4f5c\u4e3a\u964d\u89e3\u76ee\u6807\u5e76\u8fdb\u884c\u7834\u574f\u7684\u8fc7\u7a0b\u3002\u901a\u5e38\u60c5\u51b5\u4e0b\uff0c\u6cdb\u7d20\u6807\u8bb0\u4f1a\u5411\u7ec6\u80de\u5e9f\u7269\u5904\u7406\u673a\u5236\u53d1\u51fa\u4fe1\u53f7\uff0c\u8868\u660e\u86cb\u767d\u8d28\u5df2\u51c6\u5907\u597d\u88ab\u964d\u89e3\u548c\u6e05\u9664\u3002\u4f46\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u4eba\u4eec\u53d1\u73b0\u6cdb\u7d20\u5316\u5177\u6709\u4e0d\u540c\u7684\u529f\u80fd\u3002<\/p>\n


                                        <\/p>\n

                                        Trejo \u4ecb\u7ecd\u5230\uff1a\u201c\u6211\u4eec\u53d1\u73b0GPCRs\u548c\u708e\u75c7\u53d7\u5230\u6cdb\u7d20\u5316\u7684\u5f71\u54cd\uff0c\u4e4b\u524d\u4eba\u4eec\u8ba4\u4e3a\u6cdb\u7d20\u5316\u53ea\u4f1a\u6807\u8bb0\u9700\u8981\u7834\u574f\u7684\u86cb\u767d\u3002\u76f8\u53cd\uff0c\u6211\u4eec\u63ed\u793a\u4e86GPCR\u529f\u80fd\u548c\u6cdb\u7d20\u5316\u7684\u65b0\u89c1\u89e3\u3002\u201d\u5177\u4f53\u6765\u8bf4\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0GPCR\u542f\u52a8\u4e86\u4e00\u79cd\u540d\u4e3aNEDD4\u7684E3\u8fde\u63a5\u9176\uff0c\u8fd9\u79cd\u9176\u8d1f\u8d23\u6cdb\u7d20\u5316\u3002\u201c\u901a\u8fc7\u5bf9\u521d\u7ea7\u5185\u76ae\u7ec6\u80de\u8fdb\u884c\u8be6\u7ec6\u7684\u751f\u5316\u7814\u7a76\uff0c\u6211\u4eec\u53d1\u73b0\u4e0a\u8ff0\u73b0\u8c61\u89e6\u53d1\u4e86\u4e00\u7cfb\u5217\u4fe1\u53f7\u5206\u5b50\uff0c\u6700\u7ec8\u6fc0\u6d3b\u4e86p38\u4e1d\u88c2\u539f\u6fc0\u6d3b\u86cb\u767d\u6fc0\u9176\uff0c\u5b83\u662f\u708e\u75c7\u7684\u4e3b\u8981\u8c03\u8282\u5668\uff0c\u8fdb\u800c\u4fc3\u8fdb\u4e86\u708e\u75c7\u53cd\u5e94\u3002\u201d<\/p>\n


                                        <\/p>\n

                                        \u4e00\u4e9bE3\u6cdb\u7d20\u8fde\u63a5\u9176\u6291\u5236\u5242\u6700\u8fd1\u88abFDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\uff0c\u5305\u62ec\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u548c\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u8fd8\u6709\u4e00\u4e9b\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u3002Trejo\u8bf4\uff1a\u201c\u7531\u4e8e\u4eba\u4f53\u4e2d\u6709600\u5230700\u4e2a\u5177\u6709\u4e0d\u540c\u529f\u80fd\u7684E3\u8fde\u63a5\u9176\uff0c\u6240\u4ee5\u65e0\u8bba\u662f\u6279\u51c6\u7684\u8fd8\u662f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4ee5E3\u8fde\u63a5\u9176\u4e3a\u9776\u6807\u7684\u836f\u7269\u6570\u91cf\u975e\u5e38\u5c11\u3002\u201d\u5979\u8bf4\uff1a\u201c\u8fd9\u662fE3\u8fde\u63a5\u9176\u9996\u6b21\u88ab\u8bc1\u660e\u5728\u8840\u7ba1\u708e\u75c7\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\uff0c\u5927\u5927\u6269\u5c55\u4e86\u5176\u6291\u5236\u5242\u7684\u5e94\u7528\u524d\u666f\u3002\u8fd9\u65b9\u9762\u7684\u7814\u7a76\u5c1a\u5904\u4e8e\u65b0\u9636\u6bb5\u3002\u4eba\u4eec\u5728\u786e\u5b9a\u5982\u4f55\u542f\u52a8\u6cdb\u7d20\u5316\u65b9\u9762\u53d6\u5f97\u4e86\u76f8\u5f53\u5927\u7684\u8fdb\u5c55\uff0c\u4f46\u5bf9\u5982\u4f55\u5173\u95ed\u6cdb\u7d20\u5316\u5374\u77e5\u4e4b\u751a\u5c11\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u76ee\u524d\u6b63\u8bd5\u56fe\u4e86\u89e3\u8fd9\u4e00\u8fc7\u7a0b\uff0c\u4ee5\u8bc6\u522b\u5177\u6709\u6cbb\u7597\u6f5c\u529b\u7684\u5176\u4ed6\u7ec6\u80de\u9776\u6807\u3002\u201d\uff08Grimsey, N.J. et al. Rep 2018, 24(12): 3312\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        \u76ae\u80a4\u75c5<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670809\u65e5\uff0c\u4e2d\u91cd\u5ea6\u5934\u76ae\u94f6\u5c51\u75c5\u836f\u7269Otezla\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9<\/span><\/p>\n

                                        Celgene\u5ba3\u5e03\u4e86\u540d\u4e3aSTYLE \u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u8fd9\u662f\u4e00\u9879\u7528\u4ee5\u8bc4\u4f30Otezla\uff08apremilast\uff09\u5bf9\u4e2d\u91cd\u5ea6\u5934\u76ae\u6591\u5757\u578b\u94f6\u5c51\u75c5\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u6709\u5b89\u6170\u5242\u5bf9\u7167\u7684\u4e34\u5e8a\u7814\u7a76\uff08ClinicalTrials.gov\u7f16\u53f7NCT03123471\uff09\u3002\u8be5\u7814\u7a76\u62db\u52df\u4e86303\u540d\u53d7\u8bd5\u8005\uff0c\u4ed6\u4eec\u88ab\u968f\u673a\u4ee52\uff1a1\u7684\u6bd4\u4f8b\u5728\u524d16\u5468\u6bcf\u5929\u670d\u752830mg\u7684apremilast\u6216\u5b89\u6170\u5242\u3002\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u6bcf\u65e5\u4e24\u6b2130mg \u7684apremilast\u6cbb\u7597\u7ec4\u5728\u7b2c16\u5468\u7684Scalp Physician’s Global Assessment\uff08ScPGA\uff09\u8bc4\u5206\u7684\u4e3b\u8981\u7ec8\u70b9\uff08\u5b9a\u4e49\u4e3aScPGA\u8bc4\u5206\u4e3a\u6e05\u6670\u7684\uff080\u7ea7\uff09\u6216\u63a5\u8fd1\u6e05\u6670\u7684\uff081\u7ea7\uff09\uff0c\u81f3\u5c11\u6bd4\u57fa\u7ebf\u964d\u4f4e2\u4e2a\u7ea7\u522b\uff09\uff0c\u53d6\u5f97\u4e86\u7edf\u8ba1\u5b66\u610f\u4e49\u4e0a\u7684\u663e\u8457\u6539\u5584\u3002\u9664\u4e86\u4e3b\u8981\u7ec8\u70b9\u5916\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u4f7f\u7528apremilast\u60a3\u8005\u5728\u7b2c16\u5468\u7684\u5168\u8eab\u7619\u75d2\u6570\u503c\u8bc4\u5206\uff08NRS\uff0c\u5b9a\u4e49\u4e3a\u81f3\u5c11\u6bd4\u57fa\u7ebf\u964d\u4f4e4\u5206\uff09\u7684\u6b21\u8981\u7ec8\u70b9\u4e5f\u8fbe\u5230\u4e86\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u8be5\u836f\u7684\u5b89\u5168\u6027\u6570\u636e\u4e0e\u5148\u671f\u62a5\u9053\u57fa\u672c\u4e00\u81f4\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002\u5728\u4e24\u7ec4\u60a3\u8005\u4e2d\uff0c\u81f3\u5c11\u67095%\u7684\u60a3\u8005\u53d1\u751f\u4e86\u6cbb\u7597\u5f15\u8d77\u7684\u4e0d\u826f\u4e8b\u4ef6\uff1a\u4e3b\u8981\u5305\u62ec\u8179\u6cfb\uff08apremilast\u7ec430.5%\uff0c\u5b89\u6170\u5242\u7ec410.8%\uff09\uff0c\u6076\u5fc3\uff0821.5%\u548c5.9%\uff09\uff0c\u5934\u75db\uff0811.5%\u548c4.9%\uff09\u4ee5\u53ca\u5455\u5410\uff085.5%\u548c2.0%\uff09\u3002\uff08Celgene\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                        \n
                                        \n
                                        \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
                                        \n
                                        \n
                                        \n

                                        \u56fe\u4e3aApremilast\u7ed3\u6784<\/span><\/p>\n


                                        <\/p>\n

                                        \u8bca\u65ad<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670823\u65e5\uff0c\u65b0\u578b\u524d\u5217\u817a\u764c\u793a\u8e2a\u5242[18F]PSMA-7\u8fdb\u5165\u4e34\u5e8a\u5e94\u7528<\/span><\/p>\n

                                        [18F]PSMA-7\u662f\u7531\u79d1\u9686\u5927\u5b66\u3001\u4e39\u7eb3-\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u548c\u5fb7\u56fd\u5c24\u91cc\u5e0c\u7814\u7a76\u4e2d\u5fc3\u5f00\u53d1\u7684\u4e00\u79cd\u7528\u4e8e\u6307\u793a\u524d\u5217\u817a\u7279\u5f02\u6027\u819c\u6297\u539f\uff08PSMA\uff09\u9633\u6027\u75c5\u53d8\u7684PET\u6210\u50cf\u793a\u8e2a\u5242\uff0c\u5728\u6b27\u6d32\u6838\u533b\u5b66\u534f\u4f1a\u5e74\u4f1a\u4e0a\uff0c\u7814\u7a76\u4eba\u5458\u62a5\u9053\u4e86\u5b83\u7684\u53d1\u73b0\u53ca\u4e34\u5e8a\u8bc4\u4ef7\u3002<\/p>\n


                                        <\/p>\n

                                        \u7814\u7a76\u8005\u6784\u5efa\u4e86\u7ed3\u6784\u4e0d\u540c\u7684PSMA\u914d\u4f53\u4ee5\u6a21\u62df\u524d\u5217\u817a\u764c\u75c5\u53d8\uff0c\u5e76\u8bc4\u4f30\u4e86\u6b63\u5e38\u5927\u9f20PSMA+LNCaP\u7ec6\u80de\u548cPSMA+\u5468\u56f4\u795e\u7ecf\u8282\u5bf9\u793a\u8e2a\u5242\u7684\u6444\u53d6\u60c5\u51b5\u3002\u7ed3\u679c\u663e\u793a\uff0c[18F]PSMA-7\u5728\u68c0\u6d4bPSMA+\u7ec4\u7ec7\u4e0a\u8868\u73b0\u51fa\u826f\u597d\u7684\u56fe\u50cf\u8d28\u91cf\u548c\u7075\u654f\u5ea6\u3002\uff08Zlatopolskiy, B.D. et al. 31st Annu Meet Eur Assoc Nucl Med (EANM) (Oct 13-17, Dusseldorf) 2018, Abst OP-118\uff09\u3002<\/p>\n


                                        <\/p>\n

                                        \u4f7f\u7528[18F]PSMA-7\u5bf910\u4f8b\u4e0d\u540c\u524d\u5217\u817a\u764c\u60a3\u8005\u5206\u522b\u8fdb\u884c8\u6b21PET\/CT\u6210\u50cf\uff0c\u7ed3\u679c\u5b89\u5168\u53ef\u884c\u3002\u8bd5\u9a8c\u89c2\u5bdf\u5230\u7684PSMA\u8868\u8fbe\u5668\u5b98\u7684\u751f\u7406\u79ef\u7d2f\u4e0e\u9884\u671f\u6307\u6807\u4e00\u81f4\uff0c\u8f90\u5c04\u5242\u91cf\u4e0e\u5176\u4ed6[18F]\u6807\u8bb0\u7684PSMA\u914d\u4f53\u76f8\u4f3c\u3002\u8be5\u793a\u8e2a\u5242\u53ef\u4ee5\u88ab\u53ef\u7591\u75c5\u7076\u9ad8\u5ea6\u6444\u53d6\uff0c\u5e76\u5728\u8f93\u6ce8\u540e3\u5c0f\u65f6\u51fa\u73b0\u76ee\u6807\/\u57fa\u7ebf\u6bd4\u4f8b\u5cf0\u503c\u3002[18F]PSMA-7\u5df2\u8fdb\u5165\u79d1\u9686\u5927\u5b66\u7684\u4e34\u5e8a\u5e38\u89c4\u8bd5\u9a8c\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c[18F]PSMA-7\u76f8\u5bf9\u4e8e\u5176\u4ed6PSMA\u793a\u8e2a\u5242\u7684\u4f18\u52bf\u5728\u4e8e\u5176\u5927\u91cf\u751f\u4ea7\u7684\u5de5\u827a\u8fc7\u7a0b\u975e\u5e38\u7b80\u5355\u3002\uff08Hohberg, M. et al. 31st Annu Meet Eur Assoc Nucl Med (EANM) (Oct 13-17, Dusseldorf) 2018, Abst OP-458\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                        \n
                                        \n
                                        \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
                                        \n
                                        \n
                                        \n

                                        \u56fe\u4e3a[18F]PSMA-7\u7ed3\u6784<\/span><\/p>\n

                                         <\/p>\n

                                        \u836f\u7269\u8bbe\u8ba1\u4e0e\u6280\u672f<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670825\u65e5\uff0cAlexion\u548cDicerna\u5ba3\u5e03\u5408\u4f5c\u5f00\u53d1RNAi\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u8865\u4f53\u4ecb\u5bfc\u7684\u75be\u75c5<\/span><\/p>\n

                                        Alexion Pharmaceuticals\u548cDicerna Pharmaceuticals\u5ba3\u5e03\u5408\u4f5c\u5f00\u53d1RNAi\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u8865\u4f53\u4ecb\u5bfc\u7684\u75be\u75c5\u3002\u8be5\u534f\u8bae\u4e3aAlexion\u516c\u53f8\u5e26\u6765\u4e86Dicerna\u516c\u53f8\u7684\u4e24\u79cd\u76ae\u4e0b\u6ce8\u5c04\u7684\u4e34\u5e8a\u524dGalXC RNAi\u7597\u6cd5\u7684\u5168\u7403\u72ec\u5bb6\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u6743\u5229\uff0c\u540c\u65f6\u4e5f\u4e3aAlexion\u516c\u53f8\u5e26\u6765\u4e86\u4f5c\u7528\u4e8e\u53e6\u5916\u4e24\u79cd\u8865\u4f53\u901a\u8def\u9776\u6807\u7684\u4e34\u5e8a\u524dGalXC RNAi\u5206\u5b50\u7684\u72ec\u5bb6\u9009\u62e9\u6743\u3002Dicerna\u5c06\u4e3b\u5bfc\u4e34\u5e8a\u524d\u9636\u6bb5\u7684\u7814\u7a76\u548c\u5f00\u53d1\u5de5\u4f5c\uff0c\u800cAlexion\u5c06\u4e3b\u5bfc\u4eceI\u671f\u4e34\u5e8a\u9636\u6bb5\u5f00\u59cb\u7684\u5f00\u53d1\u5de5\u4f5c\u3002\u8be5\u534f\u8bae\u4e3aAlexion\u516c\u53f8\u53d6\u5f97\u4e86GalXC RNAi\u7597\u6cd5\u7684\u72ec\u5bb6\u5168\u7403\u5f00\u53d1\u8bb8\u53ef\u548c\u5546\u4e1a\u6743\u5229\u3002Dicerna\u5c06\u7acb\u5373\u83b7\u5f97\u6765\u81eaAlexion\u516c\u53f8\u76842200\u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\u548c1500\u4e07\u7f8e\u5143\u7684\u80a1\u6743\u6295\u8d44\u3002\u8be5\u5408\u4f5c\u8fd8\u7ea6\u5b9a\u4e86\u603b\u8ba1\u6700\u9ad8\u53ef\u8fbe1.05\u4ebf\u7f8e\u5143\u7684\u5f00\u53d1\u548c\u4e0a\u5e02\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u8fd8\u5305\u62ec\u672a\u6765\u7684\u9500\u552e\u91cc\u7a0b\u7891\u6b3e\u9879\u548c\u53ef\u80fd\u9ad8\u81f3\u4e24\u4f4d\u6570\u7684\u9500\u552e\u5206\u6210\u3002Dicerna\u516c\u53f8\u6b64\u524d\u53d1\u5e03\u4e86DCR-PHXC\u7597\u6cd5\u7684\u6982\u5ff5\u9a8c\u8bc1\u6027\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u76ee\u524d\u7684\u4e3b\u63a8\u9002\u5e94\u75c7\u4e3a\u539f\u53d1\u6027\u9ad8\u8349\u5c3f\u9178\u75c7\u3002\uff08Alexion Pharmaceuticals\u548cDicerna Pharmaceuticals\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        \u5185\u5206\u6ccc\u7cfb\u7edf\u75be\u75c5<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670826\u65e5\uff0cSGLT1\u7a81\u53d8\u80fd\u591f\u964d\u4f4e\u9910\u540e\u8840\u7cd6\uff0c\u53ef\u5bf9\u957f\u671f\u5fc3\u8840\u7ba1\u4ee3\u8c22\u98ce\u9669\u8d77\u5230\u4fdd\u62a4\u4f5c\u7528<\/span><\/p>\n

                                        \u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u56e2\u961f\u6700\u8fd1\u53d1\u8868\u7684\u8bba\u6587\u6307\u51fa\uff0c\u5728\u4e0d\u540c\u4eba\u7fa4\u4e2d\uff0c\u94a0\/\u8461\u8404\u7cd6\u534f\u540c\u8f6c\u8fd0\u4f53-1\uff08SGLT1\uff09\u7684\u529f\u80fd\u7834\u574f\u6027\u9519\u4e49\u7a81\u53d8\u53ef\u4ee5\u4fdd\u62a4\u4eba\u4eec\u514d\u53d7\u996e\u98df\u8bf1\u5bfc\u7684\u9ad8\u8840\u7cd6\u5f71\u54cd\u3002\u8be5\u7814\u7a76\u901a\u8fc7\u5bf9SGLT1\u529f\u80fd\u57fa\u56e0\u7a81\u53d8\u4f53\u7684\u5168\u57fa\u56e0\u6d4b\u5e8f\uff0c\u660e\u786e\u4e86\u5176\u4e0e\u80a0\u9053\u8461\u8404\u7cd6\u5438\u6536\u7684\u5173\u7cfb\u3002\u7814\u7a76\u6d4b\u8bd5\u4e86\u53d7\u8bd5\u8005\u76842 h\u53e3\u670d\u8461\u8404\u7cd6\u8010\u91cf\uff0c\u7ed3\u679c\u53d1\u73b0\uff0c\u5728\u6b27\u7f8e\u4eba\u79cd\u4e2d\uff08n = 5687\uff09\uff0c\u643a\u5e263\u79cd\u5355\u500d\u578b\u9519\u4e49\u7a81\u53d8\uff08N51S\uff0cA411T\u548cH615Q\uff0c\u9891\u7387\u4e3a6.7%\uff09\u7684\u53d7\u8bd5\u8005\uff0c\u76f8\u6bd4\u975e\u643a\u5e26\u8005\u8868\u73b0\u51fa\u8f83\u4f4e\u76842 h\u8461\u8404\u7cd6\u8010\uff08\u03b2\u7cfb\u6570-8.0\uff1b95%CI\uff1a-12.7 ~ -3.3\uff1bOR\u503c0.71\uff1b95%CI\uff1a0.59 ~ 0.86)\u3002\u8fd9\u4e00\u7ed3\u679c\u5728\u975e\u5dde\u88d4\u7f8e\u56fd\u4eba\u7fa4\uff08n = 2791\uff0c\u03b2\u7cfb\u6570-16.3\uff1b95%CI\uff1a-36.6 ~ 4.1\uff1bOR\u503c0.39\uff1b95%CI\uff1a0.17 ~ 0.91\uff09\u548c\u6b27\u6d32-\u82ac\u5170\u4eba\u7fa4\uff08n = 6784\uff1b\u03b2\u7cfb\u6570-3.2\uff1b95%CI\uff1a-6.4 ~ -0.02\uff1bOR\u503c0.81\uff1b95%CI\uff1a0.68 ~ 0.98\uff09\u4e2d\u5747\u5f97\u5230\u4e86\u4e00\u81f4\u6027\u8bc1\u5b9e\u3002\u4f5c\u8005\u9884\u6d4b\uff0c\u82e5\u8fd9\u79cdSGLT1\u6291\u5236\u5bfc\u81f4\u76842h\u8461\u8404\u7cd6\u91cf\u51cf\u5c1120 mg\/dL\uff0c\u7ecf\u8fc725\u5e74\u7684\u7d2f\u79ef\uff0c\u5e26\u6765\u7684\u7ed3\u679c\u5c06\u4f1a\u662f\u80a5\u80d6\u60a3\u75c5\u7387\u964d\u4f4e\uff08OR\u503c0.43\uff1b95%CI\uff1a0.23 ~ 0.63\uff09\uff0c\u7cd6\u5c3f\u75c5\u53d1\u75c5\u7387\u964d\u4f4e\uff08\u98ce\u9669\u6bd4HR\uff1a0.58\uff1b95%CI\uff1a0.35 ~ 0.81\uff09\uff0c\u5fc3\u529b\u8870\u7aed\u53d1\u75c5\u7387\u964d\u4f4e\uff08HR\uff1a0.53\uff1b95%CI\uff1a0.24 ~ 0.83\uff09\u548c\u6b7b\u4ea1\u7387\u964d\u4f4e\uff08HR\uff1a0.66\uff1b95%CI\uff1a0.42 ~ 0.90\uff09\u3002\u56e0\u6b64\uff0c\u4ee5SGLT1\u4e3a\u9776\u70b9\u7684\u6cbb\u7597\u6709\u671b\u80fd\u51cf\u5c11\u80a0\u9053\u8461\u8404\u7cd6\u6444\u5165\u5e76\u5bf9\u957f\u671f\u5fc3\u8840\u7ba1\u4ee3\u8c22\u5371\u9669\u56e0\u7d20\u8d77\u5230\u4fdd\u62a4\u4f5c\u7528\u3002\uff08Seidelmann, S.B. et al. J Am Coll Cardiol 2018, 72(15): 1763\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        2018\u5e7410\u670809\u65e5\uff0c\u80f0\u5c9b\u7ec6\u80de\u8868\u8fbe\u201c\u5148\u5929\u514d\u75ab\u201d\u86cb\u767d<\/span><\/p>\n


                                        <\/span><\/p>\n

                                        \u4f5c\u8005\uff1a\u7279\u7ea6\u64b0\u7a3f\u4ebaNuala Moran<\/p>\n


                                        <\/p>\n

                                        \u4e00\u76f4\u4ee5\u6765\uff0c\u8840\u6e05\u86cb\u767d\u90fd\u88ab\u8ba4\u4e3a\u662f\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7684\u652f\u67f1\uff0c\u4f46\u8fd1\u4e9b\u5e74\u6765\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u663e\u793a\u8865\u4f53C3\u4e5f\u4e0e\u5148\u5929\u514d\u75ab\u76f8\u5173\u3002\u8865\u4f53C3\u662f\u8865\u4f53\u7cfb\u7edf\u7684\u6838\u5fc3\u86cb\u767d\uff0c\u80fd\u5728\u7ec6\u80de\u4e2d\u4ea7\u751f\u5e76\u88ab\u6fc0\u6d3b\u3002\u6700\u521d\u8ba4\u4e3a\u8865\u4f53C3\u4e0e\u514d\u75ab\u7ec6\u80de\u76f8\u5173\uff0c\u4f46\u76ee\u524d\u4eba\u4eec\u6e05\u695a\u7684\u77e5\u9053\u51e0\u4e4e\u6240\u6709\u7684\u7ec6\u80de\u90fd\u80fd\u4ea7\u751fC3\u3002\u5728\u514d\u75ab\u7ec6\u80de\u548c\u975e\u514d\u75ab\u7ec6\u80de\u4e2d\u5747\u80fd\u89c2\u5bdf\u5230C3\u88ab\u6fc0\u6d3b\uff0c\u8fd9\u8868\u660e\u5148\u524d\u672a\u88ab\u63a2\u7d22\u7684C3\u529f\u80fd\u53ef\u80fd\u5177\u6709\u66f4\u5e7f\u6cdb\u7684\u751f\u7406\u5b66\u610f\u4e49\u3002<\/p>\n


                                        <\/p>\n

                                        \u745e\u5178\u9a6c\u5c14\u9ed8Lund University\u7684\u7814\u7a76\u4eba\u5458\u572810\u67084\u65e5\u7684 Metabolism\u6742\u5fd7\u7f51\u7edc\u7248\u53d1\u8868\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d\u786e\u5b9a\u4e86C3\u7ec6\u80de\u5185\u6d3b\u5316\u7684\u4e00\u4e2a\u6f5c\u5728\u7684\u91cd\u8981\u5b9e\u4f8b\u3002\u4ed6\u4eec\u53d1\u73b0C3\u5728\u80f0\u817a\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u5e76\u901a\u8fc7\u4e0e\u81ea\u566c\u76f8\u5173\u86cb\u767d16-1\uff08ATG16L-1\uff09\u7684\u76f8\u4e92\u4f5c\u7528\u6fc0\u53d1\u7ec6\u80de\u81ea\u566c\u7684\u7ba1\u5bb6\u8fc7\u7a0b\uff0c\u963b\u6b62\u4e86beta\u7ec6\u80de\u7684\u6b7b\u4ea1\u3002<\/p>\n


                                        <\/p>\n

                                        \u672c\u6587\u4f5c\u8005Ben King\u6307\u51fa\uff0c\u5c3d\u7ba1\u6700\u8fd1\u6709\u8bb8\u591a\u5728\u7ec6\u80de\u4e2d\u53d1\u73b0C3\u7684\u4f8b\u5b50\uff0c\u4f46\u79d1\u5b66\u5bb6\u4eec\u4ecd\u7136\u5bf9\u8865\u4f53C3\u4f5c\u4e3a\u7ec6\u80de\u5185\u7a33\u6001\u8c03\u8282\u5668\u5728\u5065\u5eb7\u548c\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\u6301\u6000\u7591\u6001\u5ea6\u3002King\u8bf4\uff1a\u201c\u9996\u5148\u6211\u4eec\u8bc1\u660e\u4e86C3\u662f\u5728\u7ec6\u80de\u5185\u5408\u6210\u7684\uff0c\u5176\u6b21\u5c55\u793a\u4e86\u5b83\u5982\u4f55\u4e0eATG16L-1\u76f8\u4e92\u4f5c\u7528\u4ee5\u4fc3\u8fdb\u81ea\u566c\u7684\u5177\u4f53\u673a\u5236\u3002\u201d\u4ed6\u627f\u8ba4\u81ea\u5df1\u5bf9\u8fd9\u4e9b\u53d1\u73b0\u6709\u4e9b\u60ca\u8bb6\uff0cKing\u544a\u8bc9BioWorld Science\uff1a\u201c\u6709\u4eba\u8bf4C3\u5728\u7ec6\u80de\u5185\u8d77\u4f5c\u7528\uff0c\u4e00\u5f00\u59cb\u6211\u6301\u6000\u7591\u6001\u5ea6\uff0c\u4f46\u73b0\u5728\u6211\u76f8\u4fe1\u4e86\u3002\u201d\u4e0d\u8fc7\uff0c\u5bf9\u4e8e\u90a3\u4e9b\u5f00\u53d1\u6297C3\u6297\u4f53\u548c\u591a\u80bd\u6765\u6cbb\u7597\u708e\u75c7\u7684\u836f\u7269\u6765\u8bf4\uff0c\u5fc5\u987b\u660e\u786e\u7ec6\u80de\u5185\u7684C3\u5177\u6709\u6709\u76ca\u7684\u4f5c\u7528\u3002King\u8bf4\uff1a\u201c\u76ee\u524d\u6709\u836f\u7269\u80fd\u591f\u6291\u5236C3\uff0c\u82e5\u5f97\u77e5C3\u7684\u7ec6\u80de\u4fdd\u62a4\u4f5c\u7528\uff0c\u4eba\u4eec\u6700\u597d\u53ea\u6291\u5236\u8840\u6db2\u4e2d\u7684C3\u3002\u201d<\/p>\n


                                        <\/p>\n

                                        Lund University\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u4eba\u7c7b\u80f0\u5c9b\u80fd\u591f\u9ad8\u5ea6\u8868\u8fbe\u8fd9\u79cd\u86cb\u767d\u8d28\uff0c\u57fa\u56e0\u82af\u7247\u7684\u6570\u636e\u663e\u793aC3\u4f4d\u4e8e\u80f0\u5c9b\u7ec6\u80de\u8868\u8fbe\u57fa\u56e0\u7684\u524d4%\u3002\u5bf995\u540d\u4eba\u7c7b\u6350\u8d60\u8005\u5206\u79bb\u80f0\u5c9b\u7684RNA\u5e8f\u5217\u5206\u6790\u53d1\u73b0\uff0c\u4e0e\u5065\u5eb7\u6350\u8d60\u8005\u76f8\u6bd4\uff0c2\u578b\u7cd6\u5c3f\u75c5\u6350\u8d60\u8005\u7684C3\u8868\u8fbe\u660e\u663e\u66f4\u9ad8\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u57f9\u517b\u8fc7\u7a0b\u4e2d\uff0c\u5065\u5eb7\u4f9b\u4f53\u80f0\u5c9b\u7684C3\u8868\u8fbe\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u589e\u52a0\uff0c\u8fd9\u4e00\u53d1\u73b0\u4e0e\u57f9\u517b\u7ec6\u80de\u8bf1\u5bfc\u7684\u4fc3\u708e\u75c7\u53cd\u5e94\u62a5\u9053\u76f8\u4e00\u81f4\u3002\u5728\u65b0\u9c9c\u7ec6\u80de\u4e2d\uff0c2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u80f0\u5c9bC3\u8868\u8fbe\u6bd4\u5065\u5eb7\u8005\u9ad8\u51fa158%\u3002\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\uff08HbA1c\uff09\u6d4b\u5b9a\u663e\u793a\uff0cC3\u8868\u8fbe\u6c34\u5e73\u4e0e\u4f53\u91cd\u6307\u6570\u53ca\u8840\u7cd6\u5448\u6b63\u76f8\u5173\u6027\u3002C3\u7684\u8868\u8fbe\u4e5f\u4e0e\u4fc3\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u76f8\u5173\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u53d1\u73b0\uff0c\u5728\u4e00\u4e9b\u556e\u9f7f\u7c7b\u7cd6\u5c3f\u75c5\u6a21\u578b\u4e2d\uff0c\u80f0\u5c9b\u7ec6\u80de\u4e2dC3\u7684\u8868\u8fbe\u589e\u52a0\u3002<\/p>\n


                                        <\/p>\n

                                        \u86cb\u767d\u8d28\u82af\u7247\u4f7f\u5f97\u7814\u7a76\u4eba\u5458\u5c06ATG16L-1\u4f5c\u4e3a\u4e0eC3\u7ed3\u5408\u7684\u9996\u9009\u3002\u4f7f\u7528CRISPR\/Cas9\u6572\u9664C3\u57fa\u56e0\u8bc1\u5b9e\u4e86C3\u53c2\u4e0e\u9a71\u52a8\u81ea\u566c\u8fdb\u800c\u4fc3\u8fdb\u4e86\u7ec6\u80de\u5185\u7684\u7a33\u6001\u3002\u5b9e\u9a8c\u4ea7\u751f\u7684\u514b\u9686\u7ec6\u80de\u7684\u81ea\u566c\u529f\u80fd\u53d7\u5230\u4e86\u635f\u4f24\u3002\u5f53\u66b4\u9732\u4e8e\u7cd6\u5c3f\u75c5\u81f4\u75c5\u56e0\u5b50\u68d5\u6988\u9178\u548c\u80f0\u5c9b\u6dc0\u7c89\u6837\u591a\u80bd\u4e2d\u65f6\uff0c\u7ec6\u80de\u51cb\u4ea1\u6c34\u5e73\u5347\u9ad8\u3002\u7efc\u5408\u4e0a\u8ff0\u53d1\u73b0\uff0c\u7814\u7a76\u4eba\u5458\u63d0\u51fa\uff0c\u201cC3\u7684\u8868\u8fbe\u53ef\u80fd\u57282\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u80f0\u5c9b\u4e2d\u4e0a\u8c03\uff0c\u4f5c\u4e3a\u7ec6\u80de\u4fdd\u62a4\u56e0\u5b50\u5bf9\u6297\u7ec6\u80de\u529f\u80fd\u969c\u788d\u3002\u201d<\/p>\n


                                        <\/p>\n

                                        \u5728\u4e0d\u540c\u5730\u65b9\u626e\u6f14\u4e0d\u540c\u89d2\u8272<\/p>\n


                                        <\/p>\n

                                        King\u8bf4\uff0c\u73b0\u5728\u770b\u6765C3\u57282\u578b\u7cd6\u5c3f\u75c5\u4e2d\u6709\u4e24\u79cd\u4e0d\u540c\u548c\u76f8\u53cd\u7684\u4f5c\u7528\uff1a\u5728\u8840\u6db2\u4e2d\u5f15\u53d1\u80f0\u5c9b\u7d20\u62b5\u6297\uff0c\u4f46\u5728\u7ec6\u80de\u5185\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\u3002\u201c\u5b83\u5728\u4e24\u4e2a\u4e0d\u540c\u7684\u5730\u65b9\u505a\u7740\u4e24\u4ef6\u4e0d\u540c\u7684\u4e8b\u60c5\u3002\u201dC3\u8868\u8fbe\u91cf\u7684\u53d8\u5316\u3001\u5b83\u6240\u5904\u7684\u4e9a\u7ec6\u80de\u4f4d\u7f6e\u3001\u5b83\u7684\u52a0\u5de5\u548c\u5207\u5272\u4ee5\u53caATG16L-1\u7ffb\u8bd1\u540e\u4fee\u9970\u5982\u4f55\u5f71\u54cd\u5b83\u4e0eC3\u7684\u76f8\u4e92\u4f5c\u7528\u8fdb\u800c\u8c03\u8282\u81ea\u566c\u8fc7\u7a0b\uff0c\u90fd\u662f\u672a\u6765\u9700\u8981\u63a2\u7d22\u548c\u9610\u660e\u7684\u3002King\u8bf4\uff1a\u201c\u6211\u4eec\u9700\u8981\u66f4\u591a\u5730\u4e86\u89e3\u662f\u4ec0\u4e48\u56e0\u7d20\u63a7\u5236\u7740\u80de\u5185\u548c\u80de\u5916C3\u7684\u542b\u91cf\u4ee5\u53ca\u5b83\u662f\u5982\u4f55\u5e73\u8861\u7684\u3002\u201d\u6b64\u5916\uff0c\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u5de5\u4f5c\u6765\u89e3\u91caC3\/ATG16L-1\u7684\u76f8\u4e92\u4f5c\u7528\u662f\u5982\u4f55\u8c03\u8282\u81ea\u566c\u4f53\u7684\u6210\u719f\uff0c\u901a\u8fc7\u8fd9\u4e9b\u81ea\u566c\u4f53\uff0c\u7ec6\u80de\u6210\u5206\u88ab\u5faa\u73af\u5229\u7528\u3002<\/p>\n


                                        <\/p>\n

                                        \u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\uff0cC3\u5728\u8c03\u7406\u4f5c\u7528\u4e2d\u7684\u89d2\u8272\u2014\u7ec6\u80de\u5916\u7269\u8d28\u88ab\u541e\u566c\u7ec6\u80de\u7834\u574f\u7684\u6807\u8bb0\uff0c\u53ef\u80fd\u4e0eC3\u4f5c\u4e3a\u7ec6\u80de\u5185\u8c03\u7406\u7d20\u7684\u65b0\u529f\u80fd\u76f8\u5bf9\u5e94\uff0c\u5373\u5141\u8bb8\u81ea\u566c\u4f53\u7834\u574f\u6216\u5faa\u73af\u7ec6\u80de\u5185\u7269\u8d28\u3002\u4e3a\u4e86\u8bc1\u660e\u8fd9\u4e00\u70b9\uff0c\u7814\u7a76\u4eba\u5458\u8ba1\u5212\u4ee5\u809d\u7ec6\u80de\u4e3a\u4f8b\u89c2\u5bdfC3\u662f\u5426\u5728\u5176\u4ed6\u7c7b\u578b\u7ec6\u80de\u7684\u81ea\u566c\u4e2d\u8d77\u4f5c\u7528\u3002\uff08King, B.C. et al. Metab 2018, 29: 1\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        \u80c3\u80a0\u9053\u75be\u75c5<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670829\u65e5\uff0c\u8f89\u745e\u548c\u8bfa\u534e\u5c06\u5408\u4f5c\u7814\u7a76NASH\u8054\u5408\u7597\u6cd5<\/span><\/p>\n

                                        \u8f89\u745e\u4e0e\u8bfa\u534e\u7b7e\u7f72\u4e86\u4e00\u9879\u975e\u72ec\u5bb6\u4e34\u5e8a\u5f00\u53d1\u534f\u8bae\uff0c\u4ee5\u7814\u7a76\u4e00\u79cd\u6216\u591a\u79cd\u9488\u5bf9\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u7684\u8054\u5408\u7597\u6cd5\u3002\u4e24\u5bb6\u516c\u53f8\u5c06\u8054\u5408\u8fdb\u884c\u4e34\u5e8a\u524d\u548cI\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u8be5\u7597\u6cd5\u5305\u62ec\u8f89\u745e\u7684\u5019\u9009\u836f\u7269\uff1a\u4e59\u9170\u8f85\u9176A\u7fa7\u5316\u9176\uff08ACC\uff09\u6291\u5236\u5242PF-05221304\uff08\u76ee\u524d\u5728\u4e34\u5e8aII\u671f\uff09\uff0c\u4e8c\u916f\u7518\u6cb9\u7684\u4e59\u9170\u8f6c\u79fb\u91762\uff08DGAT2\uff09\u6291\u5236\u5242PF-06865571\uff08I\u671f\uff09\u548c\u5df2\u916e\u7cd6\u6fc0\u9176\uff08KHK\uff09\u6291\u5236\u5242PF-06835919\uff08II\u671f\uff09\uff0c\u4ee5\u53ca\u8bfa\u534e\u7684\u6cd5\u5c3c\u9187X\u53d7\u4f53\uff08FXR\uff09\u6fc0\u52a8\u5242tropifexor\u3002\u8fd9\u9879\u7814\u7a76\u5c06\u91c7\u7528tropifexor\u4e0e\u4e00\u79cd\u6216\u591a\u79cd\u8f89\u745e\u516c\u53f8\u7684\u5316\u5408\u7269\u7684\u8054\u5408\u7597\u6cd5\u3002Tropifexor\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u663e\u793a\u80fd\u591f\u51cf\u5c11\u8102\u80aa\u53d8\u6027\u3001\u708e\u75c7\u548c\u809d\u810f\u7622\u75d5\u7684\u5f62\u6210\u3002\uff08\u8f89\u745e\u516c\u53f8\u65b0\u95fb\u7a3f\uff1b\u8bfa\u534e\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                        \n
                                        \n
                                        \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
                                        \n
                                        \n
                                        \n

                                        \u4e0a\u56fe\u4e3aTropifexor\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                        \n
                                        \n
                                        \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
                                        \n
                                        \n
                                        \n

                                        \u4e0a\u56fe\u4e3aPF-06835919\u7ed3\u6784<\/span><\/p>\n

                                         <\/span><\/p>\n

                                        \u611f\u67d3<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u67082\u65e5\uff0cButantan\u7814\u7a76\u6240\u7684H7N9\u6d41\u611f\u6297\u539f\u8fdb\u884cI\u671f\u7814\u7a76<\/span><\/p>\n

                                        \u5df4\u897fButantan\u7814\u7a76\u6240\u7684H7N9\u6d41\u611f\u6297\u539f\u7684I\u671f\u7814\u7a76\u76ee\u524d\u6b63\u5728\u62db\u52df\u53d7\u8bd5\u8005\uff0c\u8be5\u75ab\u82d7\u7531\u4e24\u79cd\u4e0d\u540c\u7684\u4f50\u5242\u7ec4\u6210\uff08ClinicalTrials.gov\u7f16\u53f7NCT03330899\uff09\u3002\u5df4\u897f\u9884\u8ba1\u5c06\u6709432\u540d\u5065\u5eb7\u6210\u5e74\u4eba\u53c2\u52a0\u968f\u673a\u3001\u53cc\u76f2\u3001\u6709\u5b89\u6170\u5242\u5bf9\u7167\u7684\u5242\u91cf\u63a2\u7d22\u7814\u7a76\uff0c\u4ee5\u8bc4\u4f30\u4f7f\u7528\u4f50\u5242IB160\u6216\u4f50\u5242SE\u7684H7N9\u6d41\u611f\u6297\u539f\u7684\u5b89\u5168\u6027\u548c\u514d\u75ab\u539f\u6027\u3002\u5176\u4e3b\u8981\u8861\u91cf\u6307\u6807\u5305\u62ec\u5728\u6bcf\u6b21\u6ce8\u5c04\u540e7\u5929\u5185\uff0c\u53c2\u4e0e\u8005\u548c\u672a\u7ecf\u8bf7\u6c42\u53c2\u4e0e\u8005\u7684\u5c40\u90e8\u6216\u5168\u8eab\u6027\u4e0d\u826f\u4e8b\u4ef6\uff08AEs\uff09\u7684\u4eba\u6570\u3002\u6b21\u8981\u6307\u6807\u5305\u62ec\u9644\u52a0\u7684\u5b89\u5168\u6027\u6307\u6807\u548c\u514d\u75ab\u539f\u6027\u6307\u6807\u3002\u8fd9\u9879\u7814\u7a76\u9884\u8ba1\u5c06\u4e8e2019\u5e748\u670830\u65e5\u5b8c\u6210\u3002\uff08\u6765\u6e90\u4e8eClinicalTrials.gov\u7f51\u7ad9\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        \u514d\u75ab\u8c03\u8282\u5242<\/span><\/strong><\/p>\n

                                        2018\u5e7410\u670810\u65e5\uff0c\u7528\u6765\u63d0\u9ad8\u7684\u5b89\u5168\u6027\u65b0\u53d1\u73b0<\/span><\/p>\n

                                        \u4eba\u7c7b\u80da\u80ce\uff08hESCs\uff09\u548c\u4eba\u7c7b\u591a\u80fd\uff08hPSCs\uff09\u548c\u5176\u4ed6\u6240\u6709\u7ec6\u80de\u4e00\u6837\uff0c\u80fd\u591f\u9002\u5e94\u6240\u5904\u7684\u57f9\u517b\u6761\u4ef6\u3002\u8fd9\u79cd\u9002\u5e94\u662f\u4e0d\u53ef\u907f\u514d\u7684\uff0c\u4f46\u4ece\u7814\u7a76\u7684\u89d2\u5ea6\u6765\u770b\u662f\u6709\u95ee\u9898\u7684\u3002\u800c\u5bf9hESCs\u6765\u8bf4\uff0c\u5982\u679c\u7ec6\u80de\u7cfb\u662f\u79fb\u690d\u7ec6\u80de\u7684\u57fa\u4ee3\uff0c\u8fd9\u53ef\u80fd\u4f1a\u5bfc\u81f4\u5b89\u5168\u6027\u95ee\u9898\u3002\u97e9\u56fdKonkuk\u5927\u5b66\u548c\u9996\u5c14\u56fd\u7acb\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u4e00\u79cd\u6709\u9009\u62e9\u5730\u6740\u6b7b\u9002\u5e94\u57f9\u517b\u7684hESCs\u7684\u65b9\u6cd5\u3002\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c\u57f9\u517b\u9002\u5e94\u7684hESCs\u867d\u7136\u5bf9\u5404\u79cd\u8bf1\u5bfc\u51cb\u4ea1\u7684\u523a\u6fc0\u6709\u62b5\u6297\u529b\uff0c\u4f46\u5bf9BH3\u6a21\u62df\u836f\u7269\uff08\u5305\u62ecvenetoclax\u548cnavitoclax\uff09\u5374\u5f88\u8106\u5f31\u3002\u201c\u867d\u7136\u76ee\u524d\u5df2\u7ecf\u6709\u65b9\u6cd5\u6765\u89e3\u51b3\u672a\u5206\u5316\u7684\u6b8b\u4f59hPSCs\u7684\u81f4\u7624\u6027\u98ce\u9669\uff0c\u4f46\u5177\u6709\u9057\u4f20\u7578\u53d8\u7684hPSCs\u7684\u5b89\u5168\u6027\u4ecd\u7136\u662f\u4e00\u4e2a\u4e25\u91cd\u7684\u95ee\u9898\uff0c\u201d\u4f5c\u8005\u5199\u9053\uff0c\u201c\u4f7f\u7528BH3\u6a21\u62df\u836f\u7269\u662f\u4e00\u79cd\u6709\u524d\u9014\u7684\u7b56\u7565\uff0c\u53ef\u4ee5\u660e\u786e\u5730\u6d88\u9664\u5177\u6709\u9009\u62e9\u6027\u751f\u5b58\u4f18\u52bf\u7684hESCs\u3002\u201d\uff08Cho, S.-J. et al. Stem Rep 2018, 11: 1\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                        \n
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                                        \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                        \u4e0a\u56fe\u4e3aNavitoclax\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                        \n
                                        \n
                                        \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                        \u4e0a\u56fe\u4e3aVenetoclax\u7ed3\u6784<\/span><\/p>\n

                                         <\/p>\n

                                         <\/p>\n

                                        \u4ee3\u8c22\u7c7b\u75be\u75c5<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670811\u65e5\uff0c\u65b0\u578b6-\u6c28\u57fa6-\u8131\u6c27\u591a\u7cd6\u7c7b\u5206\u5b50\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u80fd\u591f\u6cbb\u7597\u80a5\u80d6<\/span><\/p>\n

                                        \u6a2a\u6ee8\u5e02\u7acb\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u5728\u996e\u98df\u8bf1\u5bfc\u7684\u5c0f\u9f20\u80a5\u80d6\u6a21\u578b\u4e0a\u7814\u7a76\u4e86\u4e00\u79cd\u65b0\u578b6-\u6c28\u57fa-6-\u8131\u6c27\u591a\u7cd6\u5206\u5b50\u7684\u4e34\u5e8a\u524d\u6cbb\u7597\u6548\u679c\u3002\u80c6\u9178\u7ed3\u5408\u6811\u8102\u5728\u6b64\u524d\u7684\u7814\u7a76\u4e2d\u5df2\u7ecf\u663e\u793a\u4e86\u6cbb\u7597\u80a5\u80d6\u548c\u7cd6\u5c3f\u75c5\u7684\u6548\u679c\uff0c\u4f46\u901a\u5e38\u4f1a\u5f15\u8d77\u8179\u80c0\u548c\u4fbf\u79d8\u3002Paramylon\u662f\u7eff\u85fbEuglena\u4e2d\u7684\u4e00\u79cd\u6210\u5206\uff0c\u53ef\u7528\u6765\u5408\u6210\u9633\u79bb\u5b50\u578b\u76846-\u6c28\u57fa-6-\u8131\u6c27paramylon\uff08APM\uff0cKobelco Eco-Solutions\uff09\uff0c\u4f5c\u4e3a\u4e00\u79cd\u591a\u7cd6\u7c7b\u805a\u5408\u7269\uff0c\u80fd\u591f\u6a21\u62df\u80c6\u9178\u7ed3\u5408\u6811\u8102\u7684\u4f5c\u7528\u3002\u5728\u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0cAPM\u80fd\u6709\u6548\u5438\u6536\u5582\u98df\u72b6\u6001\u6a21\u62df\u4eba\u4f53\u80a0\u6db2\u4e2d\u7684\u80c6\u9178\uff0c\u5438\u6536\u7387\u7ea6\u4e3a52%\uff0c\u800c\u5bf9\u7167\u54c1paramylon\u7684\u5438\u6536\u7387\u4f4e\u4e8e10%\uff0c\u9634\u6027\u7a7a\u767d\u7684\u5438\u6536\u7387\u4e3a0%\u3002\u5728\u4f53\u5185\u5b9e\u9a8c\u4e2d\uff0c8\u5468\u5927\u7684C57BL\/6J\u96c4\u6027\u5c0f\u9f20\u88ab\u5582\u542b\u67091%\u62162% APM\u548c\u9ad8\u8102\u996e\u98df\uff08HFD\uff09\uff0c\u6cbb\u75975\u5468\u540e\uff0c\u4e0e\u5355\u7eaf\u5582\u98dfHFD\u7ec4\u5c0f\u9f20\u76f8\u6bd4\uff0c1%\u548c2% APM\u7ec4\u7684\u5c0f\u9f20\u4f53\u91cd\u589e\u52a0\u663e\u8457\u8f83\u4f4e\uff08\u5206\u522b\u4e3a7.7 g\uff0c2.7g\u548c0.2 g\uff0cP < 0.05\uff09\u30021% APM\u7ec4\u5c0f\u9f20\u7684\u7a7a\u8179\u8840\u7cd6\u548c\u6b63\u5e38\u8840\u7cd6\u503c\u663e\u8457\u964d\u4f4e\uff08\u4eceHFD\u7ec4\u7ea675\u548c160 mg\/dL\u964d\u4f4e\u5230\u7ea660\u548c75 mg\/dL\uff0cP< 0.05\uff09\u3002\u8840\u6e05\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u6c34\u5e73\u4e5f\u663e\u8457\u964d\u4f4e\uff08HFD\u7ec4\u4e3a16 mg\/dL, 1% APM\u7ec4\u4e3a9 mg\/dL\uff09\uff0c\u8840\u6e05\u80f0\u5c9b\u7d20\u6c34\u5e73\u4e5f\u51fa\u73b0\u4e0b\u964d\uff08HFD\u7ec4\u4e3a0.27\uff0c1% APM\u7ec4\u4e3a0.11\uff0cP< 0.05)\u3002\u91cd\u8981\u7684\u662f\uff0c\u8865\u5145APM\u5bf9\u98df\u7269\u6444\u5165\u6ca1\u6709\u5f71\u54cd\uff0cHFD\u30011%\u548c2% APM\u7ec4\u7684\u98df\u7269\u6444\u5165\u91cf\u5206\u522b\u4e3a75\u300182\u548c74 g\/5\u5468\u3002\u6b64\u5916\uff0cAPM\u7684\u6444\u5165\u6539\u53d8\u4e86\u7caa\u4fbf\u80c6\u9178\u7684\u7ec4\u6210\uff0c\u901a\u8fc7\u7caa\u4fbf\u7d20\u82cf\u4e39-4\u67d3\u8272\u7ed3\u679c\u8868\u660e\uff0c\u725b\u78fa-\u03b2-\u9f20\u80c6\u9178\u5360\u636e\u4e86\u4f18\u52bf\u3002\u5728\u809d\u810f\u4e2d\uff0cAPM\u7684\u6444\u5165\u53ef\u663e\u8457\u964d\u4f4e\u809d\u810f\u5c0f\u5f02\u4e8c\u805a\u4f53\u4f34\u4fa3\u5206\u5b50\uff08SHP\uff09\u7684mRNA\u6c34\u5e73\uff08HFD\u7ec4\u7ea6\u4e3a1%\uff0c2% APM\u7ec4\u7ea6\u4e3a0.5%\uff0cP < 0.05\uff09\uff0c\u5e76\u4f7fCYP7A1 mRNA\u7684\u6c34\u5e73\u663e\u8457\u5347\u9ad8\uff08HFD\u7ec4\u7ea6\u4e3a1%\uff0c2%  APM\u7ec4\u7ea6\u4e3a3.7%\uff0cP < 0.05)\u3002\u7efc\u4e0a\u6240\u8ff0\uff0cAPM\u53ef\u4ee5\u6539\u5584\u80a5\u80d6\u548c\u8461\u8404\u7cd6\u4ee3\u8c22\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u80a5\u80d6\uff08Suzuki, S. et al. 54th Annu Meet EurAssoc Study Diabetes (EASD) (Oct 2-5, Berlin) 2018, Abst 674\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                        \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                        \u56fe\u4e3a6-Amino-6-deoxyparamylon\u7ed3\u6784<\/span><\/p>\n

                                         <\/p>\n

                                        \u808c\u8089\u9aa8\u9abc\u548c\u7ed3\u7f14\u7ec4\u7ec7\u75be\u75c5<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670823\u65e5\uff0cdapirolizumab pegol\u5728\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u7684IIb\u671f\u7814\u7a76\u7ed3\u679c\u516c\u5e03<\/span><\/p>\n

                                        UCB Biopharma\u516c\u53f8\u516c\u5e03\u4e86\u4e00\u9879\u7528\u6765\u8bc4\u4f30dapirolizumab pegol\uff08DZP\uff09\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u4e34\u5e8aIIb\u671f\u7814\u7a76\u7684topline\u5206\u6790\u7ed3\u679c\u3002Dapirolizumab pegol\u662f\u4e00\u79cd\u6297CD40L\u7684\u805a\u4e59\u4e8c\u9187\u5316\u6297\u539f\u7ed3\u5408\u7247\u6bb5\uff0c\u7528\u4e8e\u6cbb\u7597\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u6d3b\u52a8\u6027\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff08SLE\uff09\uff0c\u53d7\u8bd5\u8005\u662f\u63a5\u53d7\u8fc7\u76ae\u8d28\u7c7b\u56fa\u9187\u3001\u6297\u759f\u836f\u548c\u975e\u751f\u7269\u514d\u75ab\u6291\u5236\u5242\u7b49\u6807\u51c6\u6cbb\u7597\u7684\u60a3\u8005\uff08ClinicalTrials.gov\u7f16\u53f7NCT02804763\uff09\u3002\u8fd9\u9879\u591a\u4e2d\u5fc3\u968f\u673a\u53cc\u76f2\u6709\u5b89\u6170\u5242\u5bf9\u7167\u7684\u5242\u91cf\u8303\u56f4\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u5728\u7b2c24\u5468\u57fa\u4e8eBritish Isles Lupus Assessment Group \uff08BILAG\uff09\u7684\u7efc\u5408\u6027\u72fc\u75ae\u8bc4\u4f30\u6253\u5206\uff08BICLA\uff09\uff0c\u4f46\u8be5\u7814\u7a76\u6ca1\u80fd\u8fbe\u5230\u4e0a\u8ff0\u7ec8\u70b9\u3002\u6570\u636e\u8868\u660e\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cDZP\u6cbb\u7597\u60a3\u8005\u7684\u5927\u591a\u6570\u5f97\u5230\u4e86\u4e00\u81f4\u4e14\u53ef\u80fd\u6709\u610f\u4e49\u7684\u4e34\u5e8a\u6539\u5584\u3002\u6b64\u5916\uff0c\u751f\u7269\u6807\u5fd7\u7269\u6570\u636e\u8bc1\u660e\u4e86\u8be5\u7597\u6cd5\u7684\u751f\u7269\u5b66\u8bc1\u636e\u3002DZP\u7684\u5b89\u5168\u548c\u8010\u53d7\u6027\u826f\u597d\u3002Biogen\u516c\u53f8\u548cUCB\u516c\u53f8\u5c06\u7ee7\u7eed\u8bc4\u4f30\u8fd9\u4e9b\u6570\u636e\u4ee5\u53ca\u672a\u6765\u53ef\u80fd\u91c7\u53d6\u7684\u63aa\u65bd\uff08UCB\u516c\u53f8\u65b0\u95fb\u7a3f\uff1bClinicalTrials.gov\u7f51\u7ad9\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        \u795e\u7ecf\u7c7b\u75be\u75c5<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670815\u65e5\uff0c\u9ed8\u514b\u516c\u53f8\u53d1\u8868evobrutinib\u7684\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u6570\u636e<\/span><\/p>\n

                                        \u5fb7\u56fd\u9ed8\u514b\u516c\u53f8\u7684\u7814\u7a76\u4eba\u5458\u53d1\u8868\u4e86evobrutinib\uff08M-2951\uff09\u7684\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u6570\u636e\uff0c\u8fd9\u662f\u4e00\u9879\u5355\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684I\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30evobrutinib\u5728\u5065\u5eb7\u53d7\u8bd5\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\uff0c\u8fd8\u7814\u7a76\u4e86evobrutinib\u66b4\u9732\u91cf\u4e0eQT\u95f4\u9694\u53d8\u5316\u7684\u5173\u7cfb\u3002\u6b64\u9879\u7814\u7a76\u5206\u4e24\u90e8\u5206\u8fdb\u884c\u3002\u7b2c\u4e00\u90e8\u5206\u7684\u5355\u5242\u91cf\uff08SAD\uff09\u7814\u7a76\u7eb3\u5165\u4e8648\u540d\u5065\u5eb7\u53d7\u8bd5\u8005\uff0c\u53c2\u52a0\u4e866\u4e2a\u8fde\u7eed\u5242\u91cf\u7ec4\uff0825\u300150\u3001100\u3001200\u3001350\u548c500\u6beb\u514b\uff09\u7684\u7814\u7a76\u3002\u53d7\u8bd5\u8005\u88ab\u968f\u673a\u5206\u914d\u5230\u53e3\u670devobrutinib\u6216\u5b89\u6170\u5242\u5355\u5242\u91cf\u7ec4\uff086:2\uff09\u3002\u5728\u7b2c\u4e8c\u90e8\u5206\u7684\u591a\u5242\u91cf\uff08MAD\uff09\u7814\u7a76\u4e2d\uff0c36\u540d\u53d7\u8bd5\u8005\u88ab\u7eb3\u51653\u4e2a\u722c\u5761\u5242\u91cf\u7ec4\uff0825\u300175\u548c200\u6beb\u514b\/\u5929\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u517114\u5929\uff09\uff0c\u968f\u673a\u5206\u5165evobrutinib\u6216\u5b89\u6170\u5242\u7ec4\uff089:3\uff09\u3002\u6cbb\u7597\u5f15\u53d1\u7684\u4e0d\u826f\u4e8b\u4ef6\u5927\u591a\uff08TEAEs\uff09\u662f\u8f7b\u5fae\u7684\uff0c25%\u5728\u5355\u6b21\u7ed9\u836f\u540e\u53d1\u751f\uff0c48%\u5728\u591a\u6b21\u7ed9\u836f\u540e\u53d1\u751f\u3002\u9ad8\u5242\u91cfevobrutinib\u5e76\u6ca1\u6709\u5bfc\u81f4\u4e0d\u826f\u4e8b\u4ef6\u9891\u7387\u6216\u79cd\u7c7b\u7684\u660e\u663e\u589e\u52a0\u3002\u6ca1\u6709\u6b7b\u4ea1\u6216\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u62a5\u544a\u3002\u5728\u7814\u7a76\u7684\u4efb\u4f55\u9636\u6bb5\u90fd\u6ca1\u6709\u5bfc\u81f4\u7ec8\u6b62\u598a\u5a20\u7684TEAEs\uff0c\u4e5f\u6ca1\u6709\u751f\u547d\u4f53\u5f81\u3001\u5fc3\u7535\u56fe\u3001\u5b9e\u9a8c\u5ba4\u6570\u636e\u6216\u514d\u75ab\u7403\u86cb\u767dG\u4e9a\u578b\u7684\u663e\u8457\u6539\u53d8\u3002\u5355\u6b21\u7ed9\u836f\u540e\uff0cevobrutinib\u5438\u6536\u8fc5\u901f\uff0c\u57280.5-1.0\u5c0f\u65f6\u5185\u8fbe\u5230\u5cf0\u503c\u6d53\u5ea6\u3002\u8840\u6d46\u6e05\u9664\u7387\u4e2d\u7b49\u81f3\u504f\u9ad8\uff0c\u4e2d\u95f4\u7aef\u534a\u8870\u671f\u8f83\u77ed\u3002\u5728\u7a33\u5b9a\u72b6\u6001\u4e0b\uff0c\u5316\u5408\u7269\u7684PK\u53c2\u6570\u572825-500\u6beb\u514b\u5355\u5242\u91cf\u8303\u56f4\u548c25-200\u6beb\u514b\u7684\u591a\u5242\u91cf\u8303\u56f4\u5185\u5448\u5242\u91cf\u76f8\u5173\u6027\uff0c\u572814\u5929\u7684\u91cd\u590d\u7ed9\u836f\u540e\u6ca1\u6709\u836f\u7269\u79ef\u805a\uff0c\u4e5f\u6ca1\u6709\u65f6\u95f4\u4f9d\u8d56\u6027\u3002QT\u6570\u636e\u7684\u6d53\u5ea6-\u54cd\u5e94\u6570\u636e\u663e\u793a\u8be5\u836f\u7684\u66b4\u9732\u91cf\u4e0d\u4f1a\u5f71\u54cd\u5fc3\u7535\u56fe\u3002\u7efc\u4e0a\uff0c\u8be5\u9636\u6bb5\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660eevobrutinib\u7684\u8010\u53d7\u6027\u5f88\u597d\uff0c\u5728\u5065\u5eb7\u5fd7\u613f\u8005\u4e2d\u7684PK\u53c2\u6570\u4e0e\u9884\u6d4b\u4e00\u81f4\uff0cQT\u95f4\u9694\u6ca1\u6709\u5ef6\u957f\u3002Evobrutinib\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u7528\u4e8e\u6cbb\u7597\u591a\u53d1\u6027\u786c\u5316\u75c7\uff08MS\uff09\u3001\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u548c\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684II\u671f\u7814\u7a76\u4e2d\uff08ClinicalTrials.gov \u7f16\u53f7\u5206\u522b\u4e3aNCT02975349\u3001NCT02975336\u548cNCT03233230\uff09\u3002\uff08Becker, A. et al. 34th CongrEurComm Treat Res Multiple Scler (ECTRIMS) (Oct 10-12, Berlin) 2018, Abst P551\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                        \n
                                        \n
                                        \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
                                        \n
                                        \n
                                        \n

                                        \u56fe\u4e3aEvobrutinib\u7ed3\u6784<\/span><\/p>\n

                                         <\/span><\/p>\n

                                        2018\u5e7410\u670831\u65e5\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793aBAN-2401\u53ef\u6539\u5584\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u72b6<\/span><\/p>\n

                                        \u7531Eisai\u548cBiogen\u516c\u53f8\u5f00\u53d1\u7684\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\uff08AD\uff09\u7684\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53BAN-2401\u5728\u5bf9856\u540d\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\uff08MCI\uff09\u6216\u65e9\u671fAD\u60a3\u8005\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u5bf9\u6dc0\u7c89\u6837\u86cb\u767d\u7684\u79ef\u7d2f\u5177\u6709\u6f5c\u5728\u7684\u6539\u5584\u4f5c\u7528\uff0c\u8bc1\u5b9e\u8be5\u4ea7\u54c1\u80fd\u591f\u9009\u62e9\u6027\u7ed3\u5408\u5e76\u6d88\u9664\u6dc0\u7c89\u6837\u86cb\u767d\u539f\u7ea4\u7ef4\uff08ClinicalTrials.gov\u7f16\u53f7NCT01767311\uff09\u3002\u8be5\u7814\u7a76\u7684\u4e24\u4e2a\u91cd\u8981\u7684\u7279\u70b9\u5206\u522b\u662f\u4f7f\u7528Bayesian\u8bbe\u8ba1\uff0c\u5373\u57fa\u4e8e\u6b63\u5728\u8fdb\u884c\u7684\u6cbb\u7597\u6548\u679c\u8bc4\u4f30\u5e76\u7075\u6d3b\u7684\u5c06\u53d7\u8bd5\u8005\u5206\u914d\u8fdb\u5165\u6700\u6709\u6cbb\u7597\u610f\u4e49\u7684\u5242\u91cf\u7ec4\uff1b\u5e76\u4f7f\u7528\u5305\u62ecADAS-Cog\uff08AD\u8ba4\u77e5\u8bc4\u4f30\uff09\uff0cCDR-SB\uff08\u75f4\u5446\u75c7\u4e34\u5e8a\u8bc4\u5b9a\uff09\u548cMMSE\uff08\u7ec6\u5fae\u7cbe\u795e\u72b6\u6001\u68c0\u67e5\uff09\u4e09\u9879\u7ed3\u5408\u7684ADCOMS\uff08AD\u7efc\u5408\u8bc4\u5206\u4f53\u7cfb\uff09\u6765\u8bc4\u4f30\u4e34\u5e8a\u75c7\u72b6\u3002\u867d\u7136\u8fd9\u9879\u7814\u7a76\u6ca1\u6709\u8fbe\u5230\u5176\u4e3b\u8981\u91cf\u5ea6\u6807\u51c6\uff0812\u4e2a\u6708\u65f6\u4e0e\u57fa\u7ebf\u76f8\u6bd4\uff0c\u81f3\u5c11\u670980%\u53d7\u8bd5\u8005\u5728\u75be\u75c5\u8fdb\u5c55\u65b9\u9762\u670925%\u7684\u5dee\u5f02\uff0c\u8be5\u7814\u7a76\u6570\u636e\u4e3a64%\uff09\uff0c\u4f46\u572818\u4e2a\u6708\u7684\u6700\u7ec8\u5206\u6790\u65f6\uff0c\u4f7f\u7528\u9884\u5b9a\u4e49\u7684\u4f20\u7edf\u65b9\u6cd5\u7edf\u8ba1\uff0c\u5176\u6700\u9ad8\u5242\u91cf\u6cbb\u7597\u7ec4\uff0810mg\/kg\u6bcf\u4e24\u5468\u4e00\u6b21\uff09\u76f8\u6bd4\u5b89\u6170\u5242\u7ec4\uff0c\u8fbe\u5230\u4e86\u663e\u8457\u51cf\u7f13\u75be\u75c5\u8fdb\u5c55\u7684\u5173\u952e\u4e34\u5e8a\u7ec8\u70b9\uff08ADCOMS\uff09\u548c\u901a\u8fc7PET\u626b\u63cf\u786e\u8bc1\u5176\u80fd\u591f\u663e\u8457\u51cf\u5c11\u5927\u8111\u4e2d\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u7684\u79ef\u7d2f\u3002<\/p>\n


                                        <\/p>\n

                                        \u8f7d\u8102\u86cb\u767dE4\u7684\u72b6\u6001\u5206\u914d\uff0c\u9884\u8bbe\u7684\u7ec4\u95f4\u5206\u6790\u4ee5\u53ca\u4e0e\u795e\u7ecf\u53d8\u6027\u76f8\u5173\u7684\u751f\u7269\u6807\u5fd7\u7269\u5206\u6790\u4e5f\u540c\u65f6\u8fdb\u884c\u3002\u7ec4\u95f4\u5206\u6790\u7edf\u8ba1\u663e\u793a\uff0c\u6240\u6709BAN-2401\u53d7\u8bd5\u7684\u4e9a\u7ec4\u60a3\u8005\u5728\u7814\u7a76\u4e2d\u5747\u8fbe\u5230\u4e86\u6709\u7edf\u8ba1\u610f\u4e49\u768430%\u75be\u75c5\u8fdb\u5c55\u51cf\u7f13\uff0c\u60a3\u8005\u5927\u8111\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u5f97\u5230\u4e86\u663e\u8457\u7684\u7f13\u89e3\uff0c\u4e14\u4e0a\u8ff0\u8fdb\u5c55\u4e0e\u53d7\u8bd5\u8005\u7684\u75be\u75c5\u5206\u7ea7\u548c\u4e34\u5e8a\u6cbb\u7597\u9636\u6bb5\u65e0\u5173\u3002\u6b64\u5916\uff0c\u60a3\u8005\u7684APOE4\u72b6\u6001\u5e76\u672a\u5bf9\u6cbb\u7597\u8fdb\u5c55\u4ea7\u751f\u8d21\u732e\u3002<\/p>\n


                                        <\/p>\n

                                        \u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c10 mg\/kg \u5242\u91cf\u7684BAN-2401\u7528\u836f\u7ec4\u7684\u8111\u810a\u6db2\uff08CSF\uff09\u751f\u7269\u6807\u5fd7\u7269\u6539\u53d8\u663e\u793a\u5176\u4e0e\u795e\u7ecf\u9000\u884c\u6027\u6539\u5584\u76f8\u4e00\u81f4\u3002\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cCSF\u4e2d\u7684\u7a81\u89e6\u86cb\u767dneurogranin\uff0c\u4e00\u79cd\u7a81\u89e6\u635f\u4f24\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5176\u6c34\u5e73\u572818\u4e2a\u6708\u5185\u88abBAN-2401\u51cf\u5c11\u4e8611%\uff08\u4ece\u57fa\u7ebf\u503c\u4e2d\u4f4d\u51cf\u5c11\u4e8658 pg \/mL\uff09\uff1b\u540c\u65f6\uff0cp-Tau \u86cb\u767d\u6c34\u5e73\uff0cTau\u86cb\u767d\u7684\u75c5\u7406\u7684\u6807\u5fd7\uff0c\u51cf\u5c11\u4e8613%\uff08\u4ece\u57fa\u7ebf\u503c\u4e2d\u4f4d\u51cf\u5c11\u4e8612 pg \/mL\uff09\uff1b neurofilament\u86cb\u767d\u8f7b\u94fe\u6c34\u5e73\uff0c\u8f74\u7a81\u9000\u5316\u7684\u6807\u5fd7\uff0c\u51cf\u5c11\u4e8648%\u3002\uff08Swanson, C.J. et al. 11th Clin Trials Alzheimer’s Dis (CTAD) Conf (Oct 24-27, Barcelona) 2018, Abst Symposium 3\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        \u7cbe\u795e\u7c7b\u75be\u75c5<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670819\u65e5\uff0cIPR-166\u80fd\u63d0\u9ad8\u7c7b\u7cbe\u795e\u5206\u88c2\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u8ba4\u77e5\u80fd\u529b<\/span><\/p>\n

                                        \u6765\u81eaIproteos\u7684\u7814\u7a76\u4eba\u5458\u62a5\u9053\u4e86\u65b0\u578b\u812f\u6c28\u9170\u5be1\u80bd\u9176\uff08POP\uff09\u6291\u5236\u5242IPR-166\u7528\u4e8e\u6cbb\u7597\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u76f8\u5173\u7684\u8ba4\u77e5\u969c\u788d\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e\u3002\u5728\u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0cIPR-166\u80fd\u6291\u5236\u4eba\u91cd\u7ec4POP\uff0cIC50\u4e3a37nm\u3002\u8be5\u5316\u5408\u7269\u5177\u6709\u7ec6\u80de\u6e17\u900f\u6027\uff0c\u5bf9\u6d3b\u7ec6\u80deSH-SY5Y\u7684\u80de\u5185POP\u5177\u6709\u6291\u5236\u4f5c\u7528\uff08IC50\u4e3a13 nM)\uff09\uff0c\u4e14\u5177\u5907\u5f88\u597d\u7684POP\u9009\u62e9\u6027\u3002\u91c7\u7528PAMPA\u548cCaco-2 (A-B) \u6e17\u900f\u7387\u6d4b\u5b9a\u6cd5\u5bf9IPR-166\u7684\u4f53\u5916\u6e17\u900f\u7387\u8fdb\u884c\u8bc4\u4f30\uff0c\u7ed3\u679c\u5206\u522b\u4e3a18.1%\u548c45%\uff0c\u5176(A-B)\/(B-A) \u6bd4\u4e3a0.76\uff0c\u8bf4\u660eIPR-166\u662f\u4e00\u79cd\u4f4e\u6d41\u901f\u900f\u8fc7\u6027\u5e95\u7269\u3002\u5927\u9f20\u548c\u72d7\u7684\u6bd2\u7406\u5b66\u7814\u7a76\u8868\u660eIPR-166\u7684\u5b89\u5168\u548c\u8010\u53d7\u6027\u826f\u597d\uff0c\u65e0\u4e34\u5e8a\u76f8\u5173\u75c7\u72b6\u6216\u6b7b\u4ea1\u75c5\u4f8b\u3002\u5728\u4f53\u5185\uff0cIPR-166\u7684\u836f\u7406\u6d3b\u6027\u5728\u82ef\u73af\u5df1\u54cc\u5576\uff08PCP\uff09\u7684\u4e9a\u6162\u6027\u6216\u6025\u6027\u7ed9\u836f\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002\u5728\u57fa\u7840\u6761\u4ef6\u4e0b\u548c\u53e3\u670dIPR-166\uff081 – 5 mg\/kg\uff09\u6025\u6027\u7ed9\u836f\u540e\uff0c\u91c7\u7528\u76ee\u6807\u8bc6\u522b\u6d4b\u8bd5\u3001\u8ff7\u5bab\u4ea4\u66ff\u4efb\u52a1\u548c\u5956\u8d4f\u5ef6\u8fdf\u7684\u7a7a\u95f4\u53d8\u6362\u4efb\u52a1\u5bf9\u5c0f\u9f20\u7684\u884c\u4e3a\u53cd\u5e94\u8fdb\u884c\u8bc4\u4f30\u3002\u5b9e\u9a8c\u8bc1\u660eIPR-166\u80fd\u591f\u6539\u5584\u8fd9\u4e9b\u6a21\u578b\u7684\u8ba4\u77e5\u7f3a\u9677\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u8be5\u7814\u7a76\u7ed3\u679c\u8868\u660eIPR-166\u662f\u4e00\u4e2a\u5f3a\u6548\u7684\u5177\u6709\u9009\u62e9\u6027\u548c\u6e17\u900f\u6027\u7684POP\u6291\u5236\u5242\uff0c\u80fd\u63d0\u9ad8\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u5c0f\u9f20\u6a21\u578b\u7684\u8ba4\u77e5\u80fd\u529b\uff0c\u4e3a\u8be5\u75be\u75c5\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u4e2a\u6709\u524d\u9014\u7684\u65b0\u9896\u7597\u6cd5\u3002\uff08Prades, R. et al. 31st CongrEur Coll Neuropsychopharmacol (ECNP) (Oct 6-9, Barcelona) 2018, Abst P.280\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        \u80be\u810f-\u6ccc\u5c3f\u7cfb\u7edf\u75be\u75c5<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670829\u65e5\uff0cSIM1\u57fa\u56e0\u9644\u8fd1\u7684\u5355\u57fa\u56e0\u4f4d\u70b9\u4e0e\u52c3\u8d77\u529f\u80fd\u969c\u788d\u98ce\u9669\u663e\u8457\u76f8\u5173<\/span><\/p>\n

                                        Kaiser Permanente\u548c\u5176\u9644\u5c5e\u673a\u6784\u62a5\u9053\u4e86\u9488\u5bf9\u52c3\u8d77\u529f\u80fd\u969c\u788d\uff08ED\uff09\u7684\u9996\u4e2a\u5927\u89c4\u6a21\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u7684\u6570\u636e\u3002ED\u7684GWAS\u68c0\u6d4b\u4e86\u6765\u81ea\u7f8e\u56fd\u51ef\u8428\u533b\u7597\u673a\u6784\u7684\u591a\u79cd\u65cf\u7684\u517136,349\u540d\u60a3\u8005\uff0814,215\u4f8b\u75c5\u4f8b\u548c22,434\u4f8b\u5bf9\u7167\uff09\u3002\u6b64\u5916\uff0c\u82f1\u56fdBiobank\u5bf9\u5171\u8ba1222,358\u540d\u7537\u6027\u4e5f\u8fdb\u884c\u4e86\u540c\u6837\u7684\u5206\u6790\u3002\u5728SIM1\u57fa\u56e0\u9644\u8fd1\u7684\u4e00\u4e2a\u4f4d\u70b9\u88ab\u8ba4\u4e3a\u4e0eED\u7684\u98ce\u9669\u663e\u8457\u76f8\u5173\uff0c\u5e76\u4e14\u5728\u5927\u578b\u7684\u72ec\u7acb\u7814\u7a76\u961f\u5217\u4e2d\u8bc1\u5b9e\u4e86\u8fd9\u79cd\u5173\u8054\u3002SIM1\u7f16\u7801\u4e00\u79cd\u6d3b\u8dc3\u4e8e\u7626\u7d20\u2014\u9ed1\u76ae\u8d28\u7d20\u901a\u8def\u7684\u8f6c\u5f55\u56e0\u5b50\uff0c\u8be5\u8f6c\u5f55\u56e0\u5b50\u5728\u4f53\u91cd\u5e73\u8861\u548c\u6027\u529f\u80fd\u4e2d\u8d77\u6838\u5fc3\u4f5c\u7528\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5305\u542b\u8be5\u5173\u952e\u7a81\u53d8\u57fa\u56e0\u7684\u533a\u57df\u53ef\u80fd\u4e0eSIM1\u57fa\u56e0\u7684\u542f\u52a8\u5b50\u76f8\u4e92\u4f5c\u7528\u5e76\u6539\u53d8\u4e86\u57fa\u56e0\u7684\u8868\u8fbe\u6d3b\u6027\u3002\u6700\u540e\uff0c\u4e0eED\u76f8\u5173\u7684SNPs\u4e0eBMI\u7684\u53d8\u5316\u65e0\u5173\uff0cBMI\u53d8\u5316\u540e\uff0c\u8be5\u4f4d\u70b9\u5bf9ED\u98ce\u9669\u7684\u5f71\u54cd\u5e76\u672a\u53d1\u751f\u6539\u53d8\u3002\u4e0a\u8ff0\u53d1\u73b0\u8868\u660e\uff0c\u5e26\u6709rs17185536\u6216\u5176\u4ed6\u589e\u5f3a\u6d3b\u6027\u7684ED\u76f8\u5173\u7684\u7b49\u4f4d\u57fa\u56e0\u7684SIM1\u589e\u5f3a\u5b50\u53ef\u80fd\u6d3b\u8dc3\u5728\u795e\u7ecf\u5143\u4e2d\u8fdb\u800c\u63a7\u5236\u52c3\u8d77\u529f\u80fd\uff0c\u800c\u4e0e\u63a7\u5236\u6444\u98df\u548c\u4f53\u91cd\u7684\u4f53\u5185\u5e73\u8861\u65e0\u5173\u3002\uff08Jorgenson, E. et al. 68th Annu Meet Am Soc Hum Genet (ASHG) (Oct 16-20, San Diego) 2018, Abst 2294\/F\uff09\u3002<\/p>\n

                                         <\/p>\n

                                        \u547c\u5438\u7cfb\u7edf\u75be\u75c5<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670816\u65e5\uff0cDupixent\u5728III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u80fd\u591f\u51cf\u5c0f\u9f3b\u606f\u8089\u5927\u5c0f\u5e76\u7f13\u89e3\u9f3b\u585e\u7a0b\u5ea6<\/span><\/p>\n

                                        Regeneron Pharmaceuticals\u516c\u53f8\u548cSanofi\u516c\u53f8\u5ba3\u5e03\uff0c\u7528\u4e8e\u6cbb\u7597\u60a3\u6709\u9f3b\u606f\u8089\u7684\u6210\u4eba\u6162\u6027\u9f3b\u7aa6\u708e\u7684\u836f\u7269Dupixent\uff08dupilumab\uff09\u5728\u540d\u4e3aSINUS-24\uff08n = 276\uff09\u548cSINUS-52 \uff08n = 448\uff09\u7684\u4e24\u9879\u5173\u952e\u6027\u6709\u5b89\u6170\u5242\u5bf9\u7167\u7684III\u671f\u8bd5\u9a8c\u4e2d\u8fbe\u5230\u4e86\u6240\u6709\u4e3b\u8981\u548c\u6b21\u8981\u7684\u4e34\u5e8a\u7ec8\u70b9\uff08ClinicalTrials.gov \u7f16\u53f7NCT02912468\u548cNCT02898454\uff09\u3002\u4e24\u9879\u7814\u7a76\u8fbe\u5230\u7ec8\u70b9\u65f6\uff0c\u60a3\u8005\u4f7f\u7528dupilumab\u8054\u5408\u6807\u51c6\u7684\u76ae\u8d28\u7c7b\u56fa\u9187\u9f3b\u55b7\u5242\u6cbb\u7597\u65b9\u6848\uff0c\u572824\u5468\u65f6\u5206\u522b\u53d6\u5f97\u4e8651%\u548c57%\u7684\u9f3b\u585e\u7a0b\u5ea6\u6539\u5584\uff0c\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u53ea\u4f7f\u7528\u76ae\u8d28\u7c7b\u56fa\u9187\u9f3b\u55b7\u5242\uff08\u5bf9\u7167\u7ec4\uff09\u7684\u60a3\u8005\uff0c\u4ec5\u670915%\u548c19%\u7684\u6539\u5584\uff08dupilumab\u7ec4\u7684\u8bc4\u5206\u6539\u5584\u5206\u522b\u4e3a-1.25\u5206\u548c-1.34\u5206\uff0c\u5bf9\u7167\u7ec4\u4e3a-0.38\u5206\u548c-0.45\u5206\uff0c\u8303\u56f4\u4e3a0-3\u5206\uff09\u3002\u60a3\u8005\u7684\u9f3b\u606f\u8089\u8bc4\u5206\u5206\u522b\u964d\u4f4e\u4e8627%\u548c33%\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u5219\u5206\u522b\u63d0\u9ad8\u4e864%\u548c7% \uff08dupilumab\u7ec4\u7684\u8bc4\u5206\u6539\u5584\u5206\u522b\u4e3a-1.71\u5206\u548c-1.89\u5206\uff0c\u5bf9\u7167\u7ec4\u4e3a0.10\u5206\u548c0.17\u5206\uff0c\u8303\u56f4\u4e3a0-8\u5206\uff0c\u901a\u8fc7\u5185\u7aa5\u955c\u6d4b\u91cf\u53cc\u4fa7\u606f\u8089\u5927\u5c0f\uff09\u3002\u8fd9\u4e24\u9879\u7814\u7a76\u4e5f\u8fbe\u5230\u4e86\u6240\u6709\u7684\u6b21\u8981\u7ec8\u70b9\uff0c\u5305\u62ec\u660e\u663e\u51cf\u5c11\u4e86\u5bf9\u7cfb\u7edf\u6027\u76ae\u8d28\u7c7b\u56fa\u9187\u6cbb\u7597\u6216\u624b\u672f\u6cbb\u7597\u7684\u9700\u6c42\uff0c\u6539\u5584\u4e86\u55c5\u89c9\u548c\u6162\u6027\u9f3b\u7aa6\u708e\u75c7\u72b6\u3002\u5728\u4e00\u7ec4\u9884\u5148\u8bbe\u5b9a\u7684\u5e76\u53d1\u54ee\u5598\u60a3\u8005\u4e2d\uff0cdupilumab\u663e\u8457\u6539\u5584\u4e86\u80ba\u529f\u80fd\u548c\u54ee\u5598\u63a7\u5236\u3002Dupilumab\u548c\u5bf9\u7167\u7ec4\u7684\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u5927\u81f4\u76f8\u540c\uff0c\u6ca1\u6709\u89c2\u5bdf\u5230\u4e0edupilumab\u76f8\u5173\u7684\u65b0\u7684\u6216\u610f\u5916\u7684\u526f\u4f5c\u7528\u3002\u8fd9\u4e9b\u8bd5\u9a8c\u7684\u8be6\u7ec6\u7ed3\u679c\u5c06\u4f5c\u4e3a\u63d0\u4ea4\u7533\u62a5\u6587\u4ef6\u7684\u4e00\u90e8\u5206\u3002Dupilumab\u80fd\u591f\u963b\u65adIL-4\u548cIL-13\u4fe1\u53f7\u901a\u8def\uff0c\u76ee\u524d\u5df2\u7ecf\u8bc1\u660e\u80fd\u591f\u6cbb\u7597\u4e09\u79cd2\u578b\u6216\u53d8\u5e94\u6027\u708e\u75c7\u75be\u75c5\uff0c\u5305\u62ec\u8fc7\u654f\u6027\u76ae\u708e\u3001\u54ee\u5598\u548c\u5e26\u6709\u9f3b\u606f\u8089\u7684\u6162\u6027\u9f3b\u7aa6\u708e\u3002\uff08Regeneron Pharmaceuticals\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n


                                        <\/p>\n

                                        \u836f\u7269\u6ee5\u7528\u53ca\u4e2d\u6bd2<\/span><\/strong><\/span><\/p>\n

                                        2018\u5e7410\u670829\u65e5\uff0c\u6cd5\u56fd\u6210\u4e3a\u7b2c\u4e00\u4e2a\u9500\u552ebaclofen\u5236\u5242\u4ee5\u51cf\u5c11\u9152\u7cbe\u6d88\u8d39\u7684\u56fd\u5bb6<\/span><\/p>\n

                                        Ethypharm\u516c\u53f8\u5ba3\u5e03\uff0c\u6cd5\u56fd\u56fd\u5bb6\u836f\u54c1\u548c\u4fdd\u5065\u54c1\u5b89\u5168\u673a\u6784\uff08ANSM\uff09\u6279\u51c6\u4e86\u836f\u7269Baclocur\u7684\u4e0a\u5e02\u8bb8\u53ef\uff0c\u8be5\u836f\u4e3a\u542b\u670910mg\u300120mg\u548c40mg\u4e09\u79cd\u5242\u91cf\u7684baclofen\u7247\u5242\u3002\u6cd5\u56fd\u662f\u7b2c\u4e00\u4e2a\u6279\u51c6\u4e00\u79cd\u65e8\u5728\u51cf\u5c11\u9152\u7cbe\u6d88\u8d39\u7684baclofen\u5236\u5242\u4e0a\u5e02\u9500\u552e\u7684\u56fd\u5bb6\uff0cbaclofen\u80fd\u591f\u6539\u5584\u6210\u5e74\u9ad8\u5371\u9152\u7cbe\u6d88\u8d39\u8005\u5bf9\u9152\u7cbe\u7684\u4f9d\u8d56\u6027\u3002\u8be5\u836f\u5e94\u7531\u533b\u751f\uff0c\u6700\u597d\u662f\u836f\u7269\u6210\u763e\u4e13\u5bb6\uff0c\u5728\u5176\u4ed6\u6cbb\u7597\u5931\u8d25\u540e\u5f00\u5177\u5904\u65b9\uff0c\u5e76\u5728\u786e\u4fdd\u4f9d\u4ece\u6027\u548c\u51cf\u5c11\u6d88\u8d39\u7684\u793e\u4f1a\u5fc3\u7406\u652f\u6301\u4e0b\u4f7f\u7528\u3002Baclocur\u9884\u8ba1\u5c06\u57282019\u5e74\u4e0b\u534a\u5e74\u4e0a\u5e02\uff0c\u5728\u8fd9\u4e4b\u524d\u8fd8\u9700\u7b49\u5f85\u5f53\u5c40\u7684\u6b63\u5f0f\u6279\u6587\u3001\u83b7\u5f97\u6cd5\u56fd\u536b\u751f\u90e8\u4e0b\u5c5e\u7684\u900f\u660e\u59d4\u5458\u4f1a\u7684\u610f\u89c1\uff0c\u4ee5\u53ca\u7ecf\u6d4e\u59d4\u5458\u4f1a\u5bf9\u836f\u54c1\u62a5\u9500\u4ef7\u683c\u7684\u6279\u51c6\u3002Baclocur\u6bcf\u65e5\u6700\u5927\u5242\u91cf\u4e3a80\u6beb\u514b\u3002\u4eceBaclocur\u6295\u653e\u5e02\u573a\u4e4b\u65f6\u8d77\uff0cEthypharm\u516c\u53f8\u5c06\u786e\u4fdd\u5176\u5728\u73b0\u5b9e\u751f\u6d3b\u4e2d\u7684\u4f7f\u7528\u5e76\u5c06\u53d7\u5230\u76d1\u63a7\uff0c\u5305\u62ec\u836f\u7269\u8b66\u6212\uff08CRPV\uff09\u3001\u6210\u763e\u6027\u8b66\u6212\uff08CEIP-A\uff09\u548c\u6bd2\u7269\u8b66\u6212\uff08CAP-TV\uff09\u7cfb\u7edf\uff0c\u4ee5\u4fbf\u66f4\u597d\u5730\u76d1\u7ba1\u5176\u5728\u6388\u6743\u7684\u660e\u786e\u9002\u5e94\u75c7\u8303\u56f4\u5185\u4f7f\u7528\u3002Ethypharm\u516c\u53f8\u63d0\u4ea4\u7684\u4e0a\u5e02\u6388\u6743\u7533\u8bf7\u7ecf\u8fc7\u4e86\u7279\u6b8a\u7684\u8bc4\u4f30\u7a0b\u5e8f\uff0c\u5728\u6b64\u8fc7\u7a0b\u4e2d\u5404\u76f8\u5173\u673a\u6784\u5747\u53ef\u53d1\u8868\u610f\u89c1\u3002\u8fd9\u4e9b\u673a\u6784\u5305\u62ec\u75c5\u4eba\u534f\u4f1a\u548c\u6765\u81ea\u6240\u6709\u6210\u763e\u6cbb\u7597\u9886\u57df\u4e13\u5bb6\u534f\u4f1a\u7684\u4ee3\u8868\uff0c\u5305\u62ec\u6cd5\u56fd\u56fd\u5bb6\u6210\u763e\u7814\u7a76\u534f\u4f1a\uff08French Federation for the Study of Addiction\uff09\u3001\u6cd5\u56fd\u9152\u7cbe\u7814\u7a76\u534f\u4f1a\uff08French Society for the Study of Alcohol\uff09\u3001\u6210\u763e\u8054\u5408\u4f1a\uff08Addiction Federation\uff09\u548cMG Addiction\u7b49\u3002\u5728\u591a\u90e8\u95e8\u7684\u8bc4\u4f30\u5b8c\u6210\u540e\uff0cANSM\u6700\u7ec8\u6279\u51c6\u4e86Baclocur\u7684\u4e0a\u5e02\u8bb8\u53ef\uff0c\u4f7f\u5176\u6210\u4e3a\u8be5\u516c\u53f8\u4e00\u5e74\u5185\u7b2c\u4e09\u4e2a\u5728\u6cd5\u56fd\u4e0a\u5e02\u7684\u6210\u763e\u6cbb\u7597\u836f\u7269\u3002\uff08Ethypharm\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                        \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                        \u56fe\u4e3aBaclofen\u7ed3\u6784<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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                                        \u672c\u6587\u5185\u5bb9\u6458\u81ea\u79d1\u777f\u552f\u5b89\u836f\u7269\u65b0\u95fbBioworld Science\uff0c\u79d1\u777f\u552f\u5b89\u5bf9\u672c\u6587\u7684\u5168\u90e8\u5185\u5bb9\u4ee5\u53ca\u53ef\u80fd\u9644\u5e26\u7684\u5168\u90e8\u8d44\u6599\u62e5\u6709\u5168\u90e8\u77e5\u8bc6\u4ea7\u6743\uff0c\u5e76\u53d7\u6cd5\u5f8b\u4fdd\u62a4\u3002\u7f51\u7edc\u8f6c\u8f7d\u3001\u7f16\u8bd1\u53ca\u5176\u4ed6\u5546\u4e1a\u4f7f\u7528\u8bf7\u8054\u7cfb\u5e02\u573a\u90e8\uff1ayili1@Clarivate.com
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                                        Bioworld Science \u836f\u7269\u65b0\u95fb<\/span><\/strong><\/span><\/p>\n


                                        <\/p>\n

                                        \u5468\u4e00\u81f3\u5468\u4e94\u52a8\u6001\u66f4\u65b0\u7684\u836f\u7269\u65b0\u95fb\u548cEMAIL\u8ddf\u8e2a\u63d0\u9192<\/span>
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                                        \u25a0 <\/span> \u6bcf\u5468\u4e00\u81f3\u4e94, Clarivate Analytics\u836f\u7269\u65b0\u95fb\uff08Clarivate Analytics BioWorld Science\uff09\u7cbe\u9009\u6700\u65b0\u3001\u6700\u91cd\u8981\u7684\u836f\u7269\u7814\u53d1\u65b0\u95fb\u5728\u7ebf\u53d1\u5e03\uff0c\u5e76\u4ee5\u7b80\u660e\u627c\u8981\u7684\u683c\u5f0f\u53d1\u9001\u63d0\u9192\u90ae\u4ef6\u81f3\u60a8\u7684\u90ae\u7bb1\uff0c\u5e2e\u52a9\u60a8\u5feb\u901f\u9501\u5b9a\u91cd\u8981\u7684\u65b0\u95fb\u4e8b\u4ef6\u3002<\/span><\/p>\n

                                        \u25a0<\/span>  \u60a8\u53ef\u4ee5\u5728\u7ebf\u68c0\u7d22\u6211\u4eec\u6240\u6709\u7684\u65b0\u95fb\u8d44\u6e90\uff0c\u5e76\u8bbe\u5b9a\u68c0\u7d22\u6761\u4ef6\uff08\u9650\u5b9a\u65b0\u95fb\u53d1\u751f\u7684\u65f6\u95f4\u3001\u836f\u540d\u3001\u4e13\u5229\u53f7\u3001\u516c\u53f8\u3001\u5927\u5b66\u3001\u673a\u6784\u3001\u6cbb\u7597\u7c7b\u522b\/\u5206\u7ec4\u3001\u5316\u5408\u7269\u7c7b\u578b\u3001\u4fe1\u606f\u6e90\uff09\u627e\u5230\u4e0e\u60a8\u7814\u7a76\u76f8\u5173\u7684\u5185\u5bb9\u3002\u836f\u7269\u65b0\u95fb\uff08BioWorld Science\uff09\u5185\u5bb9\u53ef\u56de\u6eaf\u81f31996\u5e74\uff0c\u5e76\u53ef\u67e5\u770b\u5316\u5b66\u7ed3\u6784\u5f0f\u3002<\/span><\/p>\n


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                                        \u836f\u7269\u65b0\u95fb\uff08BioWorld Science\uff09\u63d0\u4f9b\u5982\u4e0b\u5185\u5bb9\uff1a<\/span><\/p>\n

                                        \u25a0<\/span>  \u4ece\u6d77\u91cf\u4fe1\u606f\u6e90\u4e2d\u603b\u7ed3\u51fa\u7684\u6458\u8981\u62a5\u544a\u3002<\/span><\/p>\n

                                        \u25a0<\/span>  \u5728\u5168\u7403\u91cd\u8981\u4f1a\u8bae\u4e2d\u62ab\u9732\u7684\u65b0\u95fb\u4fe1\u606f\u3002<\/span><\/p>\n

                                        \u25a0 <\/span> \u6bcf\u5468\u66f4\u65b0\u7684\u90ae\u4ef6\u63d0\u9192\u670d\u52a1\uff0c\u4ee5\u8868\u683c\u7684\u5f62\u5f0f\u544a\u77e5\u60a8\u8fdb\u5165\u4e34\u5e8a\u524d\u5f00\u53d1\u6700\u6709\u524d\u666f\u7684\u5316\u5408\u7269\u3001lead compounds\u548c\u6700\u65b0\u7684\u4f5c\u7528\u673a\u5236\u3002<\/span><\/p>\n

                                        \u25a0<\/span>  \u6bcf\u5468\u66f4\u65b0\u7684\u90ae\u4ef6\u63d0\u9192\u670d\u52a1\uff0c\u544a\u77e5\u60a8\u5728\u7814\u836f\u7269\u7814\u53d1\u72b6\u6001\u7684\u53d8\u66f4\u3002<\/span><\/p>\n


                                        <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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                                        <\/p>\n<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

                                        \u4e2d\u6587\u7ffb\u8bd1\uff1a\u963f\u6817\u535a\u58eb Daily Drug News \u5df2\u6b63\u5f0f\u66f4\u540d\u4e3aBioWorld Science \u5feb […]<\/p>\n","protected":false},"author":1,"featured_media":67531,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/67530"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=67530"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/67530\/revisions"}],"predecessor-version":[{"id":67545,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/67530\/revisions\/67545"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/67531"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=67530"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=67530"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=67530"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}