{"id":67546,"date":"2018-11-14T01:00:00","date_gmt":"2018-12-07T04:15:49","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/05d65ee2c6\/"},"modified":"2018-12-07T12:15:57","modified_gmt":"2018-12-07T04:15:57","slug":"05d65ee2c6","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/67546\/","title":{"rendered":"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section style=\"white-space: normal;box-sizing: border-box;\">\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"font-size: 14px;box-sizing: border-box;\">\n<p style=\"text-align: justify;box-sizing: border-box;\"><span style=\"font-size: 14px;\">\u7279\u7ea6\u64b0\u7a3f\u4eba: \u9a6c\u4e50\u4f1f<\/span><\/p>\n<hr  \/>\n<p style=\"text-align: justify;box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"text-align: justify;box-sizing: border-box;\">2018\u5e7411\u67085\u65e5\uff0c\u636e\u97e9\u8054\u793e\u62a5\u9053\uff0c\u97e9\u56fdYuhan\u4e0e\u5f3a\u751f\u8fbe\u6210\u534f\u8bae\uff1aYuhan\u5c06\u5176\u65d7\u4e0b\u5904\u4e8eII\u671f\u4e34\u5e8a\u7684\u7b2c\u4e09\u4ee3EGFR\u6291\u5236\u5242\uff08lazertinib\uff09\u9664\u97e9\u56fd\u4ee5\u5916\u7684\u5168\u7403\u7814\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u6743\u5229\uff0c\u4ee5\u603b\u4ef7\u503c 12.5\u4ebf\u7f8e\u91d1\u7684\u4ef7\u683c\u6388\u6743\u7ed9\u5f3a\u751f\u3002EGFR&nbsp; T790M\u518d\u5ea6\u5f15\u53d1\u884c\u4e1a\u5173\u6ce8\u3002<\/p>\n<p style=\"text-align: justify;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">2016\u5e746\u6708\uff0c\u7b14\u8005\u66fe\u64b0\u5199\u8fc7\u4e00\u7bc7\u9898\u4e3a\u300aEGFR T790M\u8fd9\u4e2a\u70ed\u95e8\u9776\u70b9\uff0c\u6700\u8fd1\u6709\u5565\u52a8\u5411\uff1f\u300b\u7684\u6587\u7ae0\u3002\u5f7c\u65f6\uff0cAstraZeneca\uff08\u4ee5\u4e0b\u7b80\u79f0AZ\uff09\u7684Osimertinib\u4ec5\u83b7\u6279EGFR T790M\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u4e8c\u7ebf\u6cbb\u7597\u3002\u800c\u5982\u4eca\uff0cOsimertinib\u65e9\u5df2\u6210\u4e3aNSCLC\u7684\u4e00\u7ebf\u7528\u836f\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"box-sizing: border-box;\">\u65f6\u9694\u4e24\u5e74\uff0c\u8fd9\u4e2a\u9776\u70b9\u7a76\u7adf\u53d1\u751f\u4e86\u4ec0\u4e48\uff1f<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">\u6211\u4eec\u4e00\u8d77\u770b\u4e00\u4e0b2018\u5e74EGFR T790M\u7684\u5168\u7403\u6700\u65b0\u7ade\u4e89\u683c\u5c40\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"text-decoration: underline;\"><strong><span style=\"text-decoration: underline;font-size: 16px;color: rgb(104, 23, 255);\">EGFR T790M\u7ade\u4e89\u5e76\u975e\u60f3\u8c61\u7684\u90a3\u4e48\u6fc0\u70c8&nbsp;<\/span><\/strong><\/span><\/p>\n<p style=\"box-sizing: border-box;\">\u636e\u4e0d\u5b8c\u5168\u7edf\u8ba1\uff0c\u5168\u7403\u5904\u4e8e\u6d3b\u8dc3\u72b6\u6001\u7684\u3001I\u671f\u4e34\u5e8a\u4e4b\u540e\u7684EGFR T790M\u517114\u4e2a\u3002\u5176\u4e2d\u5df2\u4e0a\u5e022\u4e2a\uff0c\u6ce8\u518c\u524d1\u4e2a\u3001II\u671f6\u4e2a\uff0cI\u671f5\u4e2a\u3002\u5982\u6b64\u91cd\u78c5\u7684\u9776\u70b9\uff0c\u4ece\u6570\u91cf\u4e0a\u770b\uff0c\u7ade\u4e89\u4f3c\u4e4e\u6ca1\u60f3\u8c61\u7684\u90a3\u4e48\u6fc0\u70c8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/3-1544156150.png\" alt=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;font-size: 12px;\">Source\uff1aClarivate Analytics Cortellis Competitive Intelligence\uff08\u622a\u6b622018\/11\/11\uff09<\/span><\/p>\n<p style=\"text-align: center;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><span style=\"letter-spacing: 0px;box-sizing: border-box;\">EGFR T790M \u5168\u7403Pipeline\uff08\u90e8\u5206\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/10-1544156151.jpg\" alt=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"text-align: left;box-sizing: border-box;\"><span style=\"font-size: 12px;\">Source\uff1aClarivate Analytics Cortellis Competitive Intelligence\uff08\u622a\u6b622018\/11\/11\uff09<\/span><\/p>\n<p style=\"text-align: left;box-sizing: border-box;\"><span style=\"font-size: 12px;\"><br  \/><\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(104, 23, 255);text-decoration: underline;\"><strong><span style=\"color: rgb(104, 23, 255);text-decoration: underline;font-size: 16px;\">Osimertinib: \u7b2c\u4e09\u4ee3\u80ba\u764c\u9776\u5411\u836f\u7269\u7684\u5f00\u62d3\u8005<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u65e9\u57282015\u5e7411\u6708\uff0cAZ\u7684Osimertinib\u5c31\u4ee5II\u671f\u4e34\u5e8a\u6570\u636e\u83b7FDA\u6279\u51c6\uff0c<strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);box-sizing: border-box;\">\u6210\u4e3a\u5168\u7403\u7b2c\u4e00\u4e2a\u6cbb\u7597EGFR T790M\u7a81\u53d8\u9633\u6027NSCLC\u7684\u836f\u7269<\/span><\/strong>\u3002\u968f\u540e\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u4e0d\u65ad\u5728\u4e00\u7ebf\u62d3\u5c55\u3002<br  \/><\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">\u6574\u4f53\u6765\u770b\uff0cOsimertinib\u7684\u53d1\u5c55\u53ca\u83b7\u6279\u8def\u5f84\u5982\u4e0b\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/7-1544156152.jpg\" alt=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">Osimertinib\u7684\u53d1\u5c55\u8def\u5f84\uff0c\u4ece\u4fa7\u9762\u4f53\u73b0\u4e86AZ\u7684\u4e0a\u5e02\u7b56\u7565\uff1a<strong><span style=\"color: rgb(26, 198, 4);\">\u5148\u4ee5\u4e8c\u7ebf\u4e0a\u5e02\uff0c\u518d\u5411\u4e00\u7ebf\u62d3\u5c55<\/span><\/strong>\u3002\u800c\u652f\u6301Osimertinib\u6210\u529f\u83b7\u6279\u548c\u5347\u7ea7\u7684\uff0c\u8981\u4ece4\u4e2a\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u8bf4\u8d77\uff08AURA Extension\u3001AURA2\u3001AURA3\u3001FLAURA\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"text-align: start;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\"><span style=\"font-size: 14px;\"><span style=\"text-align: justify;\">1.\u9996\u5148\u662fAURA Extension\u53caAURA2\u3002 \u4e24\u9879II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5171\u5165\u7ec4\u4e86411\u540dEGFR T790M\u7a81\u53d8\u7684NSCLC\u60a3\u8005\uff0c\u603b\u7f13\u89e3\u7387\u5206\u522b\u4e3a57%\u548c61%\u3002<\/span><strong style=\"font-size: 14px;text-align: justify;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);box-sizing: border-box;\">\u8981\u77e5\u9053\uff0c\u5728\u8fd9\u4e4b\u524d\uff0c\u7ecf\u4e00\u4ee3EGFR-TKI\uff08\u5982\u5384\u6d1b\u66ff\u5c3c\u3001\u5409\u975e\u66ff\u5c3c\uff09\u6cbb\u7597\u540e\u51fa\u73b0EGFR T790M\u7a81\u53d8\u7684NSCLC\u60a3\u8005\u53ea\u80fd\u9009\u62e9\u526f\u4f5c\u7528\u8f83\u5927\u7684\u5316\u7597<\/span><\/strong><span style=\"text-align: justify;\">\u3002<\/span><\/span><span style=\"font-size: 14px;text-align: justify;\">\u57fa\u4e8e\u6b64\uff0c2015\u5e7411\u6708\uff0cFDA\u52a0\u901f\u6279\u51c6\u4e86\u8be5\u836f\u7528\u4e8e\u65e2\u5f80\u7ecfEGFR-TKI\u6cbb\u7597\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u4e14EGFR T790M\u7a81\u53d8\u9633\u6027\u7684NSCLC\u7684\u6cbb\u7597\u3002\u9002\u5e94\u75c7\u8bfb\u8d77\u6765\u6bd4\u8f83\u7ed5\u53e3\uff0c\u7b80\u5355\u6765\u8bb2\uff0c\u5c31\u662fEGFR\u7a81\u53d8NSCLC\u7684\u4e8c\u7ebf\u7528\u836f\u3002<\/span><strong><span style=\"font-size: 14px;text-align: justify;color: rgb(26, 198, 4);\">\u8fd9\u4e00\u9002\u5e94\u75c7\u7684\u83b7\u6279\u5bf9Osimertinib\u6765\u8bf4\u6781\u5176\u91cd\u8981\uff0c\u5b83\u4f7fOsimertinib\u6210\u4e86\u5168\u7403\u7b2c\u4e00\u4e2a\u83b7\u6279\u7684\u7b2c\u4e09\u4ee3EGFR\u6291\u5236\u5242\uff0c\u540c\u65f6\u4e5f\u5f00\u542f\u4e86\u4eba\u7c7b\u5bf9\u6297NSCLC\u7684\u65b0\u65f6\u4ee3\u3002<\/span><\/strong><\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">2.\u5176\u6b21\u662fAURA3\u3002\u8be5\u8bd5\u9a8c\u8bc4\u4f30\u4e86Osimertinib \u5bf9\u6bd4\u6807\u51c6\u5316\u7597\u7ec4\uff08\u542b\u94c2\u53cc\u836f\uff09\u5728EGFR T790M\u7a81\u53d8NSCLC\u60a3\u8005\u7fa4\u4f53\u4e2d\u7684\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\uff1a<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"box-sizing: border-box;\">Osimertinib\u7ec4\u4e0e\u6807\u51c6\u5316\u7597\u7ec4\u76f8\u6bd4\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09 \u663e\u8457\u9ad8\u4e8e\u540e\u8005\uff0810.1 \u4e2a\u6708Vs. 4.4 \u4e2a\u6708\uff09\uff0c\u5e76\u5c06EGFR T790M\u7a81\u53d8\u7684NSCLC\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e70%\uff1b<\/p>\n<\/li>\n<li>\n<p style=\"box-sizing: border-box;\">\u5728\u8111\u8f6c\u79fb\u7684\u60a3\u8005\u7fa4\u4e2d\uff0cOsimertinib\u7ec4\u7684\u4f18\u52bf\u4e5f\u975e\u5e38\u660e\u663e\uff08PFS\uff1a8.5 \u4e2a\u6708Vs. 4.2 \u4e2a\u6708\uff09\uff0c\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e68%\u3002<\/p>\n<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/1-1544156153.jpg\" alt=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 12px;\">Source\uff1aMok, T.S., et al., Osimertinib or Platinum\u2013Pemetrexed in EGFR T790M\u2013Positive Lung Cancer. 2017. 376(7): p. 629-640.<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">\u57fa\u4e8e\u4ee5\u4e0a\u6570\u636e\uff0c<strong><span style=\"color: rgb(26, 198, 4);\">2017\u5e743\u6708\uff0cFDA\u5c06Osimertinib\u4e8c\u7ebf\u7528\u836f\u7684\u201c\u52a0\u901f\u6279\u51c6\u201d\u53d8\u66f4\u4e3a\u201c\u5b8c\u5168\u6279\u51c6\u201d\u3002Osimertinib\u5728NSCLC\u4e8c\u7ebf\u7528\u836f\u7684\u5730\u4f4d\u4e0a\u7b97\u662f\u201c\u5750\u7a33\u201d\u4e86\u3002<\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">3.\u6700\u540e\u662fFLAURA\u3002\u8fd9\u4e2a\u7531556\u540d\u672a\u63a5\u53d7EGFR-TKI\u6cbb\u7597\u7684NSCLC\u60a3\u8005\u7ec4\u6210\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5934\u5bf9\u5934\u5bf9\u6bd4\u4e86Osimertinib\u4e0e\u4e00\u7ebfEGFR-TKI\uff08\u5409\u975e\u66ff\u5c3c\u6216\u5384\u6d1b\u66ff\u5c3c\uff09\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff1a<\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">Osimertinib\u7ec4\u4e0e\u4e00\u7ebfEGFR-TKI\u7ec4\u76f8\u6bd4\uff0c\u4e2d\u4f4d PFS \u663e\u8457\u9ad8\u4e8e\u540e\u8005\uff0818.9 \u4e2a\u6708Vs. 10.2 \u4e2a\u6708\uff09\uff0cOsimertinib\u5c06PFS\u5ef6\u957f\u4e86\u51e0\u4e4e\u4e00\u500d\uff0c\u5176\u4e34\u5e8a\u610f\u4e49\u4e0d\u8a00\u800c\u55bb\u3002\u6b64\u5916\uff0cOsimertinib\u8fd8\u5c06\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8654%\uff1b<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/1-1544156153-1.jpg\" alt=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 12px;\">Source\uff1aAstraZeneca, Investor science event: ESMO 2017.<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">&nbsp;\u5728\u8111\u8f6c\u79fb\u7684\u60a3\u8005\u7fa4\u4e2d\uff0cOsimertinib\u7ec4\u7684\u4e2d\u4f4dPFS\u540c\u6837\u663e\u8457\u9ad8\u4e8e\u4e00\u7ebfEGFR-TKI\u7ec4\uff0815.2 \u4e2a\u6708Vs. 9.6 \u4e2a\u6708\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/5-1544156153.jpg\" alt=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 12px;\">Source\uff1aAstraZeneca, Investor science event: ESMO 2017.<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">\u5f3a\u52b2\u7684\u7597\u6548\u4f7fFDA\u4e8e2017\u5e7410\u6708\u6388\u4e88Osimertinib\u4e00\u7ebfNSCLC\u7684\u7a81\u7834\u6027\u7597\u6cd5\u30022018\u5e744\u6708\uff0c\u53c8\u8fdb\u4e00\u6b65\u6279\u51c6\u8be5\u836f\u7528\u4e8eEGFR\u7a81\u53d8\u7684\u665a\u671fNSCLC\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);box-sizing: border-box;\">\u81f3\u6b64\uff0cOsimertinib\u6210\u529f\u5730\u4ece\u201c\u4e8c\u7ebf\u201d\u4e00\u8dc3\u8fdb\u5165\u201c\u4e00\u7ebf\u201d\uff0c\u540c\u65f6\u4e5f\u610f\u5473\u7740\u4eba\u7c7bNSCLC\u6cbb\u7597\u683c\u5c40\u7684\u6539\u53d8\u3002<\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\">\u9664\u4ee5\u4e0a4\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u5916\uff0cAZ\u542f\u52a8\u7684\u5173\u952e\u6027III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5982\u4e0b\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/5-1544156154.jpg\" alt=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u9762\u5bf9NSCLC\u5de8\u5927\u7684\u4e34\u5e8a\u9700\u6c42\uff0cOsimertinib\u7684\u5e02\u573a\u8868\u73b0\u4e5f\u76f8\u5f53\u5f3a\u52b2\uff1a\u4ec52018\u5e74\u4e0a\u534a\u5e74\uff0cOsimertinib\u5c31\u5b9e\u73b0\u5168\u7403\u6536\u51657.6\u4ebf\u7f8e\u91d1\uff08\u589e\u957f\u738789%\uff09\u3002\u5176\u4e2d\uff0c\u7f8e\u56fd\u8d21\u732e3.41\u4ebf\u7f8e\u91d1\uff0c\u6b27\u6d32\u8d21\u732e 1.39\u4ebf \u7f8e\u91d1\uff0c\u65e5\u672c\u8d21\u732e1.18\u4ebf\u7f8e\u91d1\uff0c\u65b0\u5174\u5e02\u573a\uff08\u5c24\u5176\u4e2d\u56fd\uff09\u8d21\u732e1.59\u4ebf\u7f8e\u91d1\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cOsimertinib\u5728\u4e2d\u56fd\u7684\u5e02\u573a\u589e\u957f\u7387\u9ad8\u8fbe298%\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/3-1544156154.jpg\" alt=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;font-size: 12px;\">Source\uff1aAstraZeneca&nbsp; 2018\u534a\u5e74\u62a5<\/span><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/span><\/p>\n<p style=\"box-sizing: border-box;\">\u4ece\u672a\u6765\u7684\u9500\u552e\u9884\u6d4b\u770b\uff0c\u6839\u636e\u79d1\u777f\u552f\u5b89Cortellis\u6570\u636e\uff0cOsimertinib\u57282023\u5e74\u7684\u5168\u7403\u9500\u552e\u989d\u5c06\u7a81\u783451.65\u4ebf\u7f8e\u91d1\u3002\u582a\u79f0\u201c\u8d85\u7ea7\u91cd\u78c5\u70b8\u5f39\u201d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/10-1544156155.jpg\" alt=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">Source\uff1aClarivate Analytics Cortellis Competitive Intelligence\uff08\u622a\u6b622018\/11\/11\uff09<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">Osimertinib\u5728\u4e34\u5e8a\u548c\u5546\u4e1a\u4e0a\u65e0\u7591\u662f\u6210\u529f\u7684\uff0c\u4f46NSCLC\u6cbb\u7597\u836f\u7269\u4f17\u591a\uff0c Osimertinib\u5982\u4f55\u4e0e\u8fd9\u4e9b\u836f\u7269\u914d\u5408\u4f7f\u7528\u624d\u80fd\u5b9e\u73b0\u60a3\u8005\u83b7\u76ca\u6700\u5927\u5316\uff0c\u5728\u884c\u4e1a\u5185\u4e00\u76f4\u672a\u6709\u5b9a\u8bba\u3002\u4e0d\u8fc7\uff0c2018\u5e7410\u670822\u65e5\uff0cAZ\u5728\u5fb7\u56fd\u6155\u5c3c\u9ed1\u7684ESMO\u5927\u4f1a\u4e0a\u516c\u5e03\u7684Osimertinib\u7684\u8010\u836f\u673a\u5236\u4f3c\u4e4e\u4e3a\u8fd9\u4e00\u95ee\u9898\u7684\u89e3\u51b3\u63d0\u4f9b\u4e86\u601d\u8def\u3002\u6570\u636e\u663e\u793a\uff1aOsimertinib\u4e00\u7ebf\u6cbb\u7597\u540e\u6700\u5e38\u89c1\u7684\u8010\u836f\u673a\u5236\u4e3aMET\u6269\u589e\uff0815%\uff09\u548cEGFR C797S\u7a81\u53d8\uff087%\uff09\uff0c\u6ca1\u6709\u83b7\u5f97\u6027EGFR T790M\u7a81\u53d8\u7684\u8bc1\u636e\u3002\u5728\u7b14\u8005\u770b\u6765\uff0c<strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);box-sizing: border-box;\">\u8fd9\u4e00\u7ed3\u679c\u4e0d\u4ec5\u4e3aNSCLC\u6700\u4f73\u6cbb\u7597\u7b56\u7565\u7684\u63a2\u7d22\u5960\u5b9a\u4e86\u7406\u8bba\u57fa\u7840\uff0c\u540c\u65f6\u4e5f\u4e3a\u201c\u540eOsimertinib\u65f6\u4ee3\u201d\u836f\u7269\u7684\u5f00\u53d1\u63d0\u4f9b\u4e86\u65b9\u5411\u3002<\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 17px;color: rgb(104, 23, 255);\">\u5176\u4ed6\u836f\u7269\u5f00\u53d1\u60c5\u51b5<\/span><\/strong><\/p>\n<hr  \/>\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(104, 23, 255);\"><strong><span style=\"font-size: 16px;\">\u4e00\u3001Olmutinib<\/span><\/strong><\/span><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);box-sizing: border-box;\">\u97e9\u7f8e\u533b\u836f\u7684Olmutinib\uff08HM-61713\uff09\u662f\u9664Osimertinib\u4e4b\u5916\uff0c\u5168\u7403\u7b2c\u4e8c\u4e2a\u83b7\u6279\u7528\u4e8eEGFR T790M\u7a81\u53d8\u9633\u6027NSCLC\u7684\u836f\u7269\uff0c\u4e5f\u662f\u8be5\u9886\u57df\u4ec5\u6709\u7684\u4e24\u4e2a\u83b7\u6279\u836f\u7269\u4e4b\u4e00\u3002<\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">Olmutinib\u6700\u65e9\u4e8e2016\u5e745\u670817\u65e5\u83b7\u97e9\u56fdKFDA\u6279\u51c6\u30022015\u5e7412\u6708\uff0c\u97e9\u7f8e\u516c\u5e03\u7684\u6570\u636e\u663e\u793aOlmutinib\u7684\u603b\u5e94\u7b54\u7387\u4e3a62%\u30022015\u5e747\u6708\u4e0e2015\u5e7411\u6708\uff0cBI\u548c\u518d\u9f0e\u5206\u522b\u4e0e\u97e9\u7f8e\u7b7e\u8ba2\u5408\u4f5c\u534f\u8bae\uff0cBI\u83b7\u5f97\u9664\u5927\u4e2d\u534e\u533a\u53ca\u97e9\u56fd\u7684\u5168\u7403\u6743\u5229\uff0c\u518d\u9f0e\u83b7\u5f97\u5927\u4e2d\u534e\u533a\u7684\u6743\u5229\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">\u4f46\u540e\u6765\uff0c\u57fa\u4e8eHM-EMSI-101\u548c202\u8bd5\u9a8c\u53d1\u751f\u7684\u4e24\u8d77\u4e25\u91cd\u76ae\u80a4\u6bd2\u6027\uff0cBI\u4e0e\u518d\u9f0e\u5148\u540e\u57282016\u5e7410\u6708\u548c2018\u5e743\u6708\u7ec8\u6b62\u4e86\u4e0e\u97e9\u7f8e\u7684\u5408\u4f5c\u3002Olmutinib\u7684\u83b7\u6279\u8303\u56f4\u4e5f\u4ec5\u5c40\u9650\u5728\u4e86\u97e9\u56fd\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(104, 23, 255);\">\u4e8c\u3001\u827e\u7ef4\u66ff\u5c3c<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u827e\u68ee\u751f\u7269\u7684\u827e\u7ef4\u66ff\u5c3c<strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);box-sizing: border-box;\">\u4e3a\u6211\u56fd\u81ea\u4e3b\u7814\u53d1\u7684\u7b2c\u4e09\u4ee3EGFR\u6291\u5236\u5242<\/span><\/strong>\u30022018\u5e746\u6708\u5728\u4e2d\u56fd\u9012\u4ea4NDA\u7533\u8bf7\uff0c\u4e5f\u662f\u76ee<strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);box-sizing: border-box;\">\u524d\u5168\u7403\u552f\u4e00\u4e00\u4e2a\u5904\u4e8eNDA\u7533\u62a5\u9636\u6bb5\u7684\u540c\u7c7b\u836f\u7269<\/span><\/strong>\u3002\u5176\u53d1\u5c55\u5386\u7a0b\u5982\u4e0b\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/6-1544156155.jpg\" alt=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u8be5\u836f\u80fd\u5426\u987a\u5229\u83b7\u6279\uff0c\u5e76\u5750\u4e0a\u56fd\u5185EGFR T790M\u7684\u201c\u7b2c\u4e8c\u628a\u4ea4\u6905\u201d\uff0c\u6211\u4eec\u62ed\u76ee\u4ee5\u5f85\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"letter-spacing: 0px;\"><br  \/><\/span><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 16px;\"><strong><span style=\"letter-spacing: 0px;color: rgb(104, 23, 255);\">\u4e09\u3001Lazertinib<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">Lazertinib\uff08GNS-1480\uff09\u4e3aGenosco\u548cYuhan\u5171\u540c\u5f00\u53d1\u7684\u54c1\u79cd\uff0c\u4e3aEGFR T790\u548cPD-L1\u53cc\u9776\u70b9\u6291\u5236\u5242\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">2016\u5e74 12\u6708\uff0c\u5728\u7b2c17\u5c4a\u56fd\u9645\u80ba\u764c\u5927\u4f1a\u4e0a\u516c\u5e03\u7684\u4e34\u5e8a\u524d\u6570\u636e\u663e\u793a\uff0cLazertinib\u4e0eOsimertinib\u76f8\u6bd4\uff0c\u5177\u6709\u66f4\u597d\u7684\u7597\u6548\u3001\u66f4\u9ad8\u7684\u8010\u53d7\u6027\u548c\u66f4\u5f3a\u7684\u8840\u8111\u5c4f\u969c\u7a7f\u900f\u80fd\u529b\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">2018\u5e746\u6708\uff0c\u5728\u829d\u52a0\u54e5\u53ec\u5f00\u7684 \u7b2c54\u5c4aASCO\u5927\u4f1a\u4e0a\uff0cYuhan\u516c\u5e03\u7684\u6570\u636e\u663e\u793a\uff1a<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u6709\u6548\u6027\u65b9\u9762\uff0c\u63a5\u53d7Lazertinib\u6240\u6709\u5242\u91cf\u6cbb\u7597\u7684NSCLC\u60a3\u8005\u7684\u5ba2\u89c2\u5e94\u7b54\u7387\uff08ORR\uff09\u4e3a61%\uff0cEGFR T790M\u7a81\u53d8\u60a3\u8005\u7684ORR\u4e3a66%\uff0c\u5176\u4e2d240mg\u5242\u91cf\u7ec4\u7684ORR\u9ad8\u8fbe86%\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/7-1544156156.jpg\" alt=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;font-size: 12px;\">Source\uff1aYH25448, a 3 rd Generation EGFR-TKI, in Patients with EGFR-TKI-resistant NSCLC: Phase I\/II Study Results<\/span><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\"><br  \/><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u4e0d\u826f\u53cd\u5e94\u65b9\u9762\uff0c\u63a5\u53d7Lazertinib\u6240\u6709\u5242\u91cf\u6cbb\u7597\u7684NSCLC\u60a3\u8005\u7684\u7d27\u6025\u4e0d\u826f\u53cd\u5e94\uff08TEAEs\uff09\u53d1\u751f\u7387\u4ec5\u4e3a11%\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/10-1544156157.jpg\" alt=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74EGFR T790M\u7684\u5168\u7403\u7ade\u4e89\u683c\u5c40\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 12px;\">Source\uff1aYH25448, a 3 rd Generation EGFR-TKI, in Patients with EGFR-TKI-resistant NSCLC: Phase I\/II Study Results<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">\u5f3a\u751f\u662f\u4e0d\u662f\u57fa\u4e8e\u4ee5\u4e0a\u6570\u636e\u624d\u51fa\u624b\u8d2d\u4e70\u4e86Lazertinib\u7684\u76f8\u5e94\u6743\u5229\uff0c\u6211\u4eec\u4e0d\u5f97\u800c\u77e5\u3002\u4f46\u5728\u7b14\u8005\u770b\u6765\uff0c\u5728Osimertinib\u51e0\u4e4e\u201c\u72ec\u9738\u201d\u7b2c\u4e09\u4ee3EGFR\u6291\u5236\u5242\u7684\u5f53\u4e0b\uff0c\u5bfb\u627e\u548c\u53d1\u5c55\u80fd\u4e0e\u4e4b\u6297\u8861\u7684\u54c1\u79cd\uff0c\u4e0d\u5931\u4e3a\u826f\u597d\u7684\u65f6\u673a\u3002\u6bd5\u7adf\uff0c\u5f53\u5e74\u4e0eOsimertinib\u540c\u53f0\u7ade\u6280\u7684Candidates\u90fd\u5df2\u7ecf\u201c\u94e9\u7fbd\u800c\u5f52\u201d\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">\u8fd9\u4e9b\u7ade\u4e89\u8005\u4e2d\uff0c\u6700\u51fa\u540d\u7684\u5f53\u5c5eClovis\u7684Rociletinib\u548cAstellas \u7684 Naquotinib\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(104, 23, 255);\">\u56db\u3001Rociletinib\u3001Naquotinib<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">Clovis\u7684Rociletinib\u662f\u5f53\u5e74\u4e0eOsimertinib\u5728\u5f00\u53d1\u8fdb\u5ea6\u4e0a\u4e0d\u76f8\u4e0a\u4e0b\u7684\u54c1\u79cd\u30022015\u5e747\u6708\uff0cClovis\u5411\u7f8e\u56fdFDA\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\uff0c\u4f46\u57fa\u4e8eTIGER-X \u548cTIGER-2\u4e24\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u5c55\u793a\u7684\u8f83\u4f4e\u7684ORR\uff08325\u540d\u65e2\u5f80\u7ecf\u81f3\u5c111\u79cdEGFR-TKI\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u4e14EGFR T790M\u7a81\u53d8\u9633\u6027\u7684NSCLC\u60a3\u8005\u7684ORR\u4e3a30.2%\uff09\uff0c2016\u5e744\u670813\u65e5\uff0cFDA\u54a8\u8be2\u59d4\u5458\u4f1a\u4ee512:1\u7684\u7ed3\u679c\u5426\u51b3\u4e86Rociletinib\u7684\u4e0a\u5e02\u7533\u8bf7\u3002\u65e0\u5948\u4e4b\u4e0b\uff0cClovis\u4e8e2016\u5e746\u67082\u65e5\u5ba3\u544a\u4e86Rociletinib\u7684\u7ec8\u6b62\uff0c\u5176\u72b6\u6001\u4e5f\u7531Pre-registration\u53d8\u6210\u4e86 Discontinued\u3002\u65f6\u9694\u4e24\u5e74\uff0cRociletinib\u4e0eOsimertinib\u622a\u7136\u4e0d\u540c\u7684\u547d\u8fd0\u4f9d\u65e7\u4ee4\u4eba\u627c\u8155\u957f\u53f9\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">\u65e0\u72ec\u6709\u5076\uff0c\u57fa\u4e8e\u540d\u4e3aSOLAR\u7684III\u671f\u4e34\u5e8a \u7814\u7a76\uff0c2017\u5e745\u670815\uff0cAstellas \u5ba3\u5e03\u7ec8\u6b62\u5176\u5728\u7814\u4ea7\u54c1Naquotinib\u7684\u7814\u7a76\u5de5\u4f5c\uff0c\u5177\u4f53\u539f\u56e0\u672a\u77e5\u3002\u8fd9\u4e2a\u88ab\u5bc4\u4e88\u539a\u671b\u7684\u54c1\u79cd\uff0c\u51fa\u4eba\u610f\u6599\u7684\u5c31\u6b64\u6b62\u6b65III\u671f\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">\u9664\u4ee5\u4e0a\u54c1\u79cd\u5916\uff0c\u5904\u4e8eII\u671f\u4e34\u5e8a\u7684EGFR T790M\u8fd8\u6709\uff1a\u8bfa\u534e\uff0c\u8c6a\u68ee\u3001\u4e0a\u6d77\u827e\u529b\u65af\u3001\u6c5f\u82cf\u5965\u8d5b\u5eb7 \u3001\u82cf\u5dde\u6da6\u65b0\u7b49\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">\u7bc7\u5e45\u539f\u56e0\uff0c\u8fd9\u4e9b\u54c1\u79cd\u4e0d\u518d\u4e00\u4e00\u8bc4\u8ff0\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"box-sizing: border-box;\"><strong><span style=\"font-size: 17px;color: rgb(104, 23, 255);\">\u7ed3\u8bed<\/span><\/strong><\/p>\n<hr  \/>\n<p><strong style=\"box-sizing: border-box;\"><span style=\"font-size: 15px;color: rgb(104, 23, 255);box-sizing: border-box;\">\u4e00\u3001\u4e24\u5e74\u591a\u7684\u65f6\u95f4\uff0c\u5168\u7403EGFR T790M\u7684\u7ade\u4e89\u683c\u5c40\u53d8\u5316\u4e0d\u5927\u3002<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\"  style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">2016\u5e746\u6708\uff0c\u7b14\u8005\u8ddf\u8e2a\u8be5\u9776\u70b9\u65f6\uff0c\u5168\u7403\u5df2\u6709\u4e24\u4e2a\u4ea7\u54c1\u83b7\u6279\uff0c\u800c\u5982\u4eca\u4f9d\u65e7\u8fd8\u662f\u90a3\u4e24\u4e2a\u3002\u4e0d\u8fc7\uff1a<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">1\u3001Osimertinib\u5df2\u4e0d\u518d\u662f\u5f53\u5e74\u521d\u51fa\u8305\u5e90\u7684EGFR T790M\uff0c\u5b83\u4e0d\u4ec5\u83b7\u5f97\u4e86\u4e8c\u7ebf\u7528\u836f\u7684\u201c\u5b8c\u5168\u6279\u51c6\u201d\uff0c\u5728NSCLC\u4e00\u7ebf\u7528\u836f\u65b9\u9762\u4e5f\u53d6\u5f97\u4e86\u5de8\u5927\u7684\u7a81\u7834\u3002\u4f5c\u4e3a\u8be5\u9886\u57df\u7684First-in-class\uff0cOsimertinib\u8fd9\u4e2a\u201c\u8d85\u7ea7\u91cd\u78c5\u70b8\u5f39\u201d\uff0c\u51e0\u4e4e\u201c\u72ec\u9738\u201d\u4e86\u6574\u4e2a\u7b2c\u4e09\u4ee3EGFR\u6291\u5236\u5242\u7684\u5929\u4e0b\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">2\u3001\u4e24\u5e74\u524d\u88ab\u5e7f\u6cdb\u770b\u597d\u7684Olmutinib\uff0c\u56e0\u5b89\u5168\u6027\u95ee\u9898\uff0c\u5176\u83b7\u6279\u8303\u56f4\u4ec5\u5c40\u9650\u5728\u4e86\u97e9\u56fd\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"box-sizing: border-box;\">3\u3001\u201c\u540d\u4e0d\u89c1\u7ecf\u4f20\u201d\u7684Lazertinib\uff0c\u5176\u5f3a\u52b2\u7684\u4e34\u5e8a\u6570\u636e\u4f7f\u5176\u5728\u4eca\u5e74\u7684ASCO\u5927\u4f1a\u4e0a\u201c\u4e00\u9e23\u60ca\u4eba\u201d\uff0c\u800c\u5f3a\u751f12.5\u4ebf\u7f8e\u91d1\u7684\u51fa\u4ef7\u8ba9\u5b83\u5728\u533b\u836f\u754c\u4e5f\u51e0\u4e4e\u4e00\u591c\u4e4b\u95f4\u5bb6\u55bb\u6237\u6653\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\">4\u3001\u5728\u611f\u53f9Rociletinib\u547d\u8fd0\u7684\u540c\u65f6\uff0c\u88ab\u5bc4\u4e88\u539a\u671b\u7684Naquotinib\u3001Mavelertinib\u7b49Candidates\u63a5\u8fde\u5931\u5229\u7684\u6d88\u606f\uff0c\u628a\u201c\u65b0\u53d1\u7684\u9ad8\u98ce\u9669\u201d\u8be0\u91ca\u7684\u6dcb\u6f13\u5c3d\u81f4 \u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: 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