{"id":67595,"date":"2018-11-06T01:00:00","date_gmt":"2018-12-07T04:16:13","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/72df01c769\/"},"modified":"2018-12-07T12:16:14","modified_gmt":"2018-12-07T04:16:14","slug":"72df01c769","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/67595\/","title":{"rendered":"\u963f\u5c14\u5179\u6d77\u9ed8\u75c5\u5982\u4f55\u5b9e\u73b0\u7cbe\u51c6\u6cbb\u7597\uff1f"},"content":{"rendered":"
\n

\u539f\u6587\u4f5c\u8005\uff1aMichael Fitzhugh<\/span><\/p>\n

\n

\u4e2d\u6587\u7ffb\u8bd1\uff1aHimalaya<\/span>\uff0c\u6821\u5bf9\uff1a\u7f8a\u7f8a<\/span><\/p>\n


<\/p>\n

\u5728\u897f\u73ed\u7259\u5df4\u585e\u7f57\u90a3\u4e3e\u884c\u76842018\u963f\u5c14\u5179\u6d77\u9ed8\u75c5\u4e34\u5e8a\u8bd5\u9a8c\u4f1a\u8bae(CTAD)\u4e0a\uff0c\u767e\u5065(Biogen)\u548c\u536b\u6750(Eisai)\u516c\u5e03\u4e86BAN-2401\u7684\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff0c\u7ed3\u679c\u975e\u5e38\u4ee4\u4eba\u4e0d\u89e3\u548c\u5931\u671b\u3002\u4e4b\u540e\u7684\u7b2c\u4e8c\u5929\uff0cAnavex\u751f\u7269\u5236\u836f\u516c\u53f8\u5e26\u6765\u4e86\u5176\u5148\u5bfc\u5019\u9009\u836f\u7684\u53e3\u5934\u62a5\u544a\u3002\u4e0e\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u6cbb\u7597\u9014\u5f84\u622a\u7136\u4e0d\u540c\u7684\u662f\uff0cANAVEX-2-73\u662f\u4e00\u79cd\u53e3\u670dsigma-1\u53d7\u4f53(S1R)\u6fc0\u52a8\u5242\uff0c\u4ece\u7ed3\u6784\u4e0a\u800c\u8a00\uff0c\u8fd9\u662f\u4e00\u79cd\u56db\u6c22\u544b\u5583\u884d\u751f\u7269\uff0c\u80fd\u4e0eM1\u53d7\u4f53\u7ed3\u5408\uff0c\u4ee5\u6539\u5584\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u7684\u65e5\u5e38\u751f\u6d3b\u6d3b\u52a8\u91cf\u8868 (ADCS-ADL)\u8bc4\u5206\u3001\u7cbe\u795e\u8fd0\u52a8\u529f\u80fd\u3001\u4e13\u6ce8\u529b\u548c\u5de5\u4f5c\u8bb0\u5fc6\u80fd\u529b\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u963f\u5c14\u5179\u6d77\u9ed8\u75c5\u5982\u4f55\u5b9e\u73b0\u7cbe\u51c6\u6cbb\u7597\uff1f\"<\/p>\n


<\/span><\/p>\n

\u6700\u65b0\u7684\u6570\u636e\u663e\u793a\uff0c\u5728\u8fd9\u5bb6\u603b\u90e8\u4f4d\u4e8e\u7ebd\u7ea6\u7684\u516c\u53f8\u5f00\u5c55\u7684\u4e00\u9879\u4e3a\u671f5<\/span>\u5e74\u7684<\/span>IIa<\/span>\u671f<\/span>\u62d3\u5c55\u6027\u4e34\u5e8a\u8bd5\u9a8c<\/span>\u4e2d\uff0c\u7ecf\u8fc7148\u5468\u7684\u6cbb\u7597\uff0cADCS-ADL\u548c\u7b80\u6613\u7cbe\u795e\u72b6\u6001\u68c0\u67e5\u8868(MMSE)\u7684\u8bc4\u5206\u5747\u8868\u660e\uff0c\u60a3\u8005\u7684\u63a2\u7d22\u6027\u529f\u80fd\u548c\u8ba4\u77e5\u4e0eANAVEX-2-73\u7684\u5242\u91cf\u5b58\u5728\u76f8\u5173\u6027\uff0c\u670d\u752850mg\u7684\u9ad8\u5242\u91cf\u7ec4\u60a3\u8005\u4e0e\u4f4e\u5242\u91cf\u7ec4\u60a3\u8005\u76f8\u6bd4\uff0cADCS-ADL (p<0.0001)\u548cMMSE(p<0.0008)\u4e24\u9879\u6307\u6807\u90fd\u8fbe\u5230\u663e\u8457\u6027\u5dee\u5f02\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u5728\u8bd5\u9a8c\u7684\u7b2c57\u5468\u65f6\uff0c\u5f71\u54cd\u836f\u7269\u5e94\u7b54\u6c34\u5e73\u7684\u4e24\u9879<\/span>\u57fa\u56e0\u751f\u7269\u6807\u8bb0\u7269<\/span>SIGMAR1(p<0.0080) \u548c(COMT)(p<0.0014)\u83b7\u5f97\u533a\u5206\u754c\u5b9a\u548c\u9274\u522b\uff0c\u800c\u4e14\u5728148\u5468\u7684\u65f6\u95f4\u5185\u4e5f\u5f97\u5230\u4e86\u786e\u8ba4\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u5728\u4e3a\u671f148\u5468\u7684\u8bd5\u9a8c\u4e2d\uff0cANAVEX-2-73\u663e\u793a\u51fa\u559c\u4eba\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u5e76\u672a\u51fa\u73b0\u4e0e\u836f\u7269\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\u6216\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u62a5\u544a\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u867d\u7136\u8be5\u9879\u8bd5\u9a8c\u53ea\u62db\u52df\u4e8632\u4f8b\u53d7\u8bd5\u8005\uff0c\u4f46\u662f\u6240\u6709\u4eba\u90fd\u53c2\u4e0e\u4e86\u62d3\u5c55\u6027\u7814\u7a76\uff0c\u8fd9\u4e3a\u8be5\u516c\u53f8\u63d0\u4f9b\u4e86\u4e00\u79cd\u6570\u636e\u79ef\u7d2f\uff0c\u4ee5\u4fbf\u89c2\u5bdf\u957f\u671f\u6cbb\u7597\u6548\u679c\u3002<\/span><\/p>\n

 <\/span><\/p>\n

Anavex\u7684\u603b\u88c1\u517cCEO Christopher Missling\u544a\u8bc9BioWorld\uff1a\u201c\u6700\u60ca\u4eba\u7684\u53d1\u73b0\u662f\uff0c\u572857\u5468\u4e4b\u540e\u7684\u4e09\u81c2\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cADCS-ADL\u53caMMSE\u4e24\u9879\u8bc4\u5206\u5e76\u6ca1\u6709\u51fa\u73b0\u663e\u8457\u6027\u5dee\u5f02\u3002\u201d\u6362\u53e5\u8bdd\u8bf4\uff0c\u63a5\u53d7\u9ad8\u5242\u91cf\u6301\u7eed\u6cbb\u7597\u7684\u60a3\u8005\uff0c3\u5e74\u5185\u4f3c\u4e4e\u6ca1\u6709\u51fa\u73b0\u8ba4\u77e5\u6216\u529f\u80fd\u7684\u4e0b\u964d\u3002<\/span><\/p>\n

 <\/span><\/p>\n

Missling\u8865\u5145\u8bf4\u9053\uff0c\u836f\u7269\u7684\u6301\u7eed\u6027\u7597\u6548\u662f\u975e\u5e38\u559c\u4eba\u7684\uff0c\u5c24\u5176\u662f\u9488\u5bf9\u8fd9\u79cd\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3002\u6bcf\u4e00\u4e2a\u7eb3\u5165\u7814\u7a76\u7684\u60a3\u8005\uff0c\u8ba4\u77e5\u548c\u529f\u80fd\u76f8\u6bd4\u57fa\u7ebf\u6c34\u5e73\u7684\u4e0b\u964d\u60c5\u51b5\u4e0e\u65e9\u671fAD\u8fdb\u7a0b\u4e00\u81f4\uff0c\u8fd9\u8bf4\u660e\u60a3\u8005\u5728\u8fd9\u4e09\u5e74\u4e2d\uff0c\u8ba4\u77e5\u548c\u529f\u80fd\u6c34\u5e73\u5e76\u6ca1\u6709\u51fa\u73b0\u8fdb\u4e00\u6b65\u4e0b\u964d\uff0c\u8fd9\u70b9\u975e\u5e38\u8ba9\u4eba\u9f13\u821e\u3002<\/span><\/p>\n

 <\/span><\/p>\n

ANAVEX-2-73 \u53ef\u6fc0\u6d3b<\/span>SIGMAR1<\/span>\u57fa\u56e0\uff0c\u540e\u8005\u53ef\u9776\u5411\u4f5c\u7528\u4e8e\u86cb\u767d\u8d28\u9519\u8bef\u6298\u53e0\u3001\u6c27\u5316\u5e94\u6fc0\u3001\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u3001\u708e\u75c7\u548c\u7ec6\u80de\u5e94\u6fc0\uff0c\u4ece\u800c\u8d77\u5230\u9499\u79bb\u5b50\u7a33\u6001\u548c\u7a81\u89e6\u53ef\u5851\u6027\u7684\u7ec6\u80de\u5185\u5206\u5b50\u4f34\u4fa3\u548c\u529f\u80fd\u8c03\u8282\u5242\u7684\u4f5c\u7528\u3002\u8be5\u591a\u4e2d\u5fc3\u7684\u4e34\u5e8aIIa\u8bd5\u9a8c\u7531\u4e24\u90e8\u5206\u7ec4\u6210\uff0c\u7eb3\u5165\u7814\u7a76\u768432\u4f8b\u60a3\u8005\u4e0d\u4f46\u7ecf\u8fc7MRI\u548c\/\u6216PET-CT\u5f71\u50cf\u786e\u8bca\u4e3a\u8f7b\u4e2d\u5ea6AD\uff0c\u800c\u4e14\u8fd8\u7ecf\u8fc7SIGMAR1(rs1800866)\u548cCOMT (rs113895332\/rs61143203)\u4e24\u9879\u751f\u7269\u57fa\u56e0\u6807\u8bb0\u7269\u7684\u53d8\u5f02\u60c5\u51b5\u7b5b\u9009\u3002PartA\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u3001\u4e24\u5468\u671f\u3001\u4ea4\u53c9\u8bd5\u9a8c\uff0c\u53d7\u8bd5\u8005\u5206\u522b\u63a5\u53d7(30mg\/50mg) \u53e3\u670d\u548c (3mg\/5mg) \u9759\u6ce8\u7ed9\u836f\uff0c\u6301\u7eed\u6cbb\u75975\u5468\u3002Part B\u662f\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u4e3a\u671f52\u5468\u7684\u62d3\u5c55\u6027\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u6307\u6807\u4e3aANAVEX-2-73\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u6700\u5927\u8010\u53d7\u5242\u91cf\uff0c\u6b21\u8981\u7ec8\u70b9\u662f\u5242\u91cf\u76f8\u5173\u6027\u3001\u751f\u7269\u5229\u7528\u5ea6\uff0c\u57fa\u4e8eMMSE\u3001ADCS-ADL\u3001Cogstate \u8ba4\u77e5\u91cf\u8868\u548cEEG\/ERP\u7b49\u591a\u9879\u6307\u6807\u7684\u63a2\u7d22\u6027\u8ba4\u77e5\u548c\u529f\u80fd\u8bc4\u4f30\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u5f00\u653e\u5f0f\u6269\u5c55\u8bd5\u9a8c\u8fd8\u989d\u5916\u5ef6\u957f\u4e86208\u5468\uff0c\u65e8\u5728\u8bc4\u4f30\u60a3\u8005\u5b8c\u6210\u4e3a\u671f52\u5468\u7684Part B\u8bd5\u9a8c\u540e\uff0c\u7d2f\u8ba1\u4f7f\u7528ANAVEX-2-73\u4e94\u5e74\u7684\u5b89\u5168\u6027\u3002\u8bd5\u9a8c\u4e2d\uff0c\u6211\u4eec\u6bcf\u4e09\u4e2a\u6708\u4e00\u6b21\u4f7f\u7528MMSE\u548cADCS-ADL\u4e24\u9879\u91cf\u8868\uff0c\u5bf9\u53c2\u4e0e\u8005\u8fdb\u884c\u4e3b\u8981\u7ec8\u70b9(\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027)\u548c\u6b21\u8981\u7ec8\u70b9(\u8ba4\u77e5\u548c\u529f\u80fd\u6c34\u5e73)\u8bc4\u4f30\u3002<\/span><\/p>\n

 <\/span><\/p>\n

Missling\u8ba4\u4e3a\uff0c\u5728\u751f\u7269\u6807\u5fd7\u7269\u65b9\u9762\uff0c\u4e09\u5e74\u671f\u6570\u636e\u663e\u793a\u51fa\u4e86\u4e0e57\u5468\u6570\u636e\u76f8\u540c\u7684\u76f8\u5173\u6027\uff0c\u56e0\u6b64\u8be5\u53d1\u73b0\u5f88\u597d\u89e3\u91ca\u4e86Anavex\u5173\u4e8eSIGMAR1\u57fa\u56e0\u7a81\u53d8\u5047\u8bf4\u3002\u8bd5\u9a8c\u8868\u660e\uff0c\u4e0d\u643a\u5e26\u8be5\u53d8\u5f02\u7684\u4eba\u7fa4\u7597\u6548\u66f4\u597d\uff0c\u4e0d\u8fc7\u597d\u5728\u5b58\u5728\u8fd9\u79cd\u57fa\u56e0\u7a81\u53d8\u7684\u60a3\u8005\u53ea\u5360\u5c11\u6570\uff0c\u5927\u7ea6\u53ea\u670910%-20%\u3002<\/span><\/p>\n

 <\/span><\/p>\n

Anavex \u8fd0\u7528Ariana Pharma AS\u516c\u53f8\u63d0\u4f9b\u7684KEM(Knowledge Extraction and Management)\u8f6f\u4ef6\u5e73\u53f0\u8fdb\u884c\u751f\u7269\u5316\u5b66\u3001\u57fa\u56e0\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u3001\u57fa\u56e0\u3001\u4ee3\u8c22\u7269\u7b49\u6570\u636e\u5206\u6790\uff0c\u5e76\u5c1d\u8bd5\u627e\u5230ANAVEX-2-73\u53ef\u80fd\u7684\u54cd\u5e94\u4eba\u7fa4\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u4eca\u5e748\u6708\uff0cAnavex\u542f\u52a8\u4e86\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u300148\u5468\u7684\u751f\u7269\u6807\u8bb0\u7269\u5bfc\u5411\u7684II\/III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u76ee\u6807\u662f\u5728\u5927\u7ea6450\u540d\u60a3\u8005\u4e2d\u8bc4\u4f30ANAVEX-2-73\u7684\u7597\u6548\uff0c\u8bd5\u9a8c\u5c06\u60a3\u8005\u4ee51:1:1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d72\u79cd\u5242\u91cf\u7684Anavex 2-73\u6216\u5b89\u6170\u5242\u6cbb\u7597(\u89c1 BioWorld, Aug. 29, 2018.)\u3002Missling\u8868\u793a\u672c\u6b21\u516c\u5e03\u76843\u5e74\u7814\u7a76\u7ed3\u679c\u9a8c\u8bc1\u4e86\u8fd9\u9879\u57fa\u4e8eIIa\u671f57\u5468\u7814\u7a76\u6570\u636e\u7684II\/III\u671f\u7684\u8bd5\u9a8c\u8bbe\u8ba1\u3002Anavex \u6392\u9664\u4e86\u6bcf\u7ec4\u643a\u5e26SIGMAR1\u548cCOMT\u57fa\u56e0\u53d8\u5f02\u7684\u4e2a\u4f53\u8fdb\u884c\u540c\u7c7b\u6bd4\u8f83\uff0c\u89c2\u6d4b\u8be5\u836f\u662f\u5426\u5728\u91ce\u751f\u578b SIGMAR1\u4eba\u7fa4\u4e2d\u5177\u6709\u66f4\u663e\u8457\u7597\u6548\u3002<\/span><\/p>\n

 <\/span><\/p>\n

Missling\u8bf4\uff1a\u201c\u6211\u4eec\u589e\u52a0\u4e86\u8fd9\u9879\u8bd5\u9a8c\u6210\u529f\u7684\u53ef\u80fd\u6027\uff0c\u56e0\u4e3a\u6211\u4eec\u786e\u4fdd\u4e86\u7814\u7a76\u6210\u679c\u53ea\u53ef\u80fd\u4ece\u90a3\u4e9b\u6709\u53ef\u80fd\u5f97\u5230\u6539\u5584\u7684\u75c5\u4eba\u4e0a\u4ea7\u751f\u3002\u201dMissling\u8ba4\u4e3a\u8fd9\u79cd\u65b9\u6cd5\u53ef\u88ab\u79f0\u4e3a\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u9886\u57df\u7684\u201c\u7cbe\u51c6\u533b\u7597\u201d\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u5c24\u5176\u662fAD\uff0c\u4e25\u91cd\u7f3a\u4e4f\u201c\u7cbe\u51c6\u533b\u7597\u201d\uff0c\u662fCTAD\u5927\u4f1a\u4e0a\u91ca\u653e\u51fa\u6765\u7684\u5173\u952e\u4fe1\u606f\u3002\u636eMissling\u6240\u8a00\uff1a\u201c\u5c31\u50cf\u5728\u80bf\u7624\u9886\u57df\u5f97\u5173\u6ce8\u57fa\u56e0\u60c5\u51b5\u4e00\u6837\uff0c\u5728AD\u4e0a\u7684\u2018\u7cbe\u51c6\u6cbb\u7597\u2019\uff0c\u6211\u4eec\u53ef\u80fd\u662f\u884c\u4e1a\u9996\u5bb6\uff0c\u800c\u4e14\u7ed3\u679c\u4e5f\u8bc1\u5b9e\u6211\u4eec\u7684\u65b9\u5411\u662f\u6b63\u786e\u7684\u3002\u201d\u5728\u5e15\u91d1\u68ee\u75c5\u3001\u75f4\u5446\u548c\u96f7\u7279\u7efc\u5408\u75c7\u7684\u7814\u7a76\u4e0a\uff0cAnavex\u4e5f\u7528\u4e86\u76f8\u540c\u7684\u65b9\u6cd5\uff0c\u76f8\u5173\u8bd5\u9a8c\u6b63\u5728\u5f00\u5c55\u6216\u8005\u8ba1\u5212\u5728\u5e74\u5e95\u5f00\u5c55\u3002<\/span><\/p>\n

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10\u670826\u65e5\uff0cAnavex\u80a1\u4ef7(\u7eb3\u65af\u8fbe\u514b:AVXL)\u5f00\u76d8\u5f3a\u52b2\uff0c\u4e0a\u6da8\u8fd116%\uff0c\u6536\u4e8e2.52\u7f8e\u5143\uff0c\u6700\u7ec8\u4e0a\u6da80.10\u7f8e\u5143\uff0c\u6da8\u5e454.1%\u3002<\/span><\/p>\n

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\u767e\u5065\u548c\u536b\u6750\u575a\u4fe1\u4ed6\u4eec\u540c\u6837\u9075\u5faa\u4e86AD\u7814\u7a76\u7684\u79d1\u5b66\u6027\uff0c\u4f46\u662f\u5206\u6790\u5e08\u5bf9\u6700\u65b0\u516c\u5e03\u7684BAN-2401\u6570\u636e\u8868\u793a\u7591\u60d1\u30027\u6708\u516c\u5e03\u7684\u6700\u65b0II\u671f\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0c\u7ecf18\u4e2a\u6708\u6cbb\u7597\uff0c<\/span>\u63a5\u53d7\u8fd9\u79cd\u03b2<\/span>\u6dc0\u7c89\u6837\u86cb\u767d\u539f\u7ea4\u7ef4\u6297\u4f53<\/span>\u6700\u9ad8\u5242\u91cf\u6cbb\u7597\u7684\u60a3\u8005\uff0cPET-CT\u6d4b\u91cf\u7ed3\u679c\u663e\u793a\u8111\u6dc0\u7c89\u6837\u86cb\u767d\u663e\u8457\u6027\u4e0b\u964d(p<0.0001)\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7efc\u5408\u8bc4\u5206(ADCOMS\uff0c\u536b\u6750\u81ea\u4e3b\u5f00\u53d1\u7684\u8bc4\u4f30\u91cf\u8868)\u7684\u4e0b\u964d\u5f97\u5230\u663e\u8457\u6027\u6539\u5584\uff0c\u5e45\u5ea6\u8fbe30%(p=0.034)\u3002\u57fa\u4e8e18\u4e2a\u6708\u7684ADCOMS\u6570\u636e\u5206\u6790\uff0c\u76f8\u6bd4\u5b89\u6170\u5242\uff0c\u5728\u6700\u9ad8\u5242\u91cf\u4e0b\uff0cAPOE4\u57fa\u56e0\u7a81\u53d8\u60a3\u8005\u75be\u75c5\u8fdb\u5c55\u4e0b\u964d63%\uff0c\u800c\u975e\u7a81\u53d8\u60a3\u8005\u4ec5\u4e3a7%\u3002\u5408\u5e76\u6bcf\u4e24\u5468\u4e00\u6b21\u7ed9\u836f10mg\/kg\u5242\u91cf\u7ec4\u548c\u6bcf\u6708\u4e00\u6b21\u7ed9\u836f10mg\/kg\u5242\u91cf\u7ec4\u6570\u636e\uff0c\u572818\u4e2a\u6708\u65f6\uff0cADCOMS\u8bc4\u5206\u4e0b\u964d\u7a0b\u5ea6\u76f8\u6bd4\u5b89\u6170\u5242\u663e\u8457\u51cf\u5c11(\u6574\u4f53\u6c34\u5e73\u4e3a21%\uff0c\u5176\u4e2dAPOE4\u7a81\u53d8\u60a3\u8005\u4e3a25%\uff0c\u800c\u975eAPOE4\u7a81\u53d8\u60a3\u8005\u4ec5\u4e3a6%)(\u89c1BioWorld,July 9, 2018\u548c July 27, 2018.)\u3002<\/span><\/p>\n

 <\/span><\/p>\n

H.C. Wainwright\u7684\u5206\u6790\u5e08AndrewFein \u8bf4\u9053\uff1a\u201c\u95ee\u9898\u770b\u4f3c\u5f88\u96be\u89e3\u51b3\uff0cBAN-2401\u7684\u6700\u65b0\u6570\u636e\u89e3\u51b3\u4e86\u4e00\u4e9b\u8001\u95ee\u9898\uff0c\u5374\u4e5f\u4ea7\u751f\u4e86\u4e00\u4e9b\u65b0\u7684\u95ee\u9898\u201d\u3002\u4ed6\u627f\u8ba4\u767e\u5065\u548c\u536b\u6750\u5728\u8fd9\u6837\u8ff7\u96fe\u91cd\u91cd\u7684\u8bd5\u9a8c\u4e2d\u5206\u6790\u51fa\u8fd9\u6837\u7684\u6570\u636e\u786e\u5b9e\u4e0d\u6613\uff0c\u867d\u7136\u4ed6\u503e\u5411APOE4\u7684\u53d8\u5f02\u60c5\u51b5\u5bf9\u4e8eAD\u7684\u75be\u75c5\u8fdb\u7a0b\u5f71\u54cd\u4e0d\u5927\uff0c\u4f46\u8ba4\u4e3aBAN-2401\u53ef\u80fd\u6709\u4e00\u5b9a\u7684\u6cbb\u7597\u6548\u679c\u3002<\/span><\/p>\n

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Je\ufb00eries \u7684\u5206\u6790\u5e08 Michael Yee\u5728\u5feb\u62a5\u4e2d\u540c\u610f\u4e86\u8fd9\u4e00\u70b9\uff0c\u4ed6\u8ba4\u4e3a\u5c3d\u7ba1\u5927\u5bb6\u5174\u81f4\u52c3\u52c3\u5730\u6765\u53c2\u52a0CTAD\uff0c\u5374\u4ee5\u4e00\u5806\u590d\u6742\u65b0\u95ee\u9898\u800c\u7ed3\u675f\uff0c\u800c\u4e14\u8fd9\u4e9b\u95ee\u9898\u5bf9\u4e8e\u4e13\u5bb6\u4eec\u800c\u8a00\u4e5f\u540c\u6837\u68d8\u624b\u3002<\/span><\/p>\n

 <\/span><\/p>\n

J.P. Morgan \u7684\u5206\u6790\u5e08 CoryKasimov\u5bf9\u4e8eBAN-2401\u6570\u636e\u516c\u5e03\u662f\u8fd9\u6837\u8bb0\u5f55\uff1a\u201c\u8d77\u7801\u5f88\u591a\u65b9\u9762\u4e9f\u5f85\u6d88\u5316\u3002\u867d\u7136\u5f97\u5230\u4e86\u4e00\u4e9b\u7b54\u6848\uff0c\u4f46\u540c\u6837\u4e5f\u7559\u4e0b\u4e86\u5f88\u591a\u95ee\u9898\u3002\u6709\u51e0\u4e2a\u8bc1\u636e\u89c2\u70b9\u4f3c\u4e4e\u81ea\u76f8\u77db\u76fe\u3002\u8fd9\u5bf9\u6211\u4eec\u6765\u8bf4\uff0c\u65e0\u7591\u589e\u52a0\u4e86\u8be5\u9002\u5e94\u75c7\u7684\u836f\u7269\u5f00\u53d1\u96be\u5ea6\uff0c\u4ee5\u53ca\u518d\u6b21\u8bc1\u660eAD\u662f\u591a\u4e48\u96be\u4ee5\u653b\u514b\u3002\u201d<\/span><\/p>\n

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\u540c\u65f6\u4ed6\u8ba4\u4e3a\uff1a\u201c\u57fa\u4e8e\u6dc0\u7c89\u6837\u6591\u5757\u6e05\u9664\u524d\u63d0\u4e0b\uff0c\u901a\u8fc7\u4ea4\u53c9\u5206\u6790\u6cd5\u5bf9\u7edd\u5927\u90e8\u5206\u6570\u636e\u8fdb\u884c\u5206\u6790\uff0c\u6211<\/span>\u4eec\u53ef\u4ee5\u80af\u5b9a\u7684\u662f\uff0c\u8be5\u836f\u603b\u4f53\u6765\u8bf4\u4f3c\u4e4e\u5bf9\u8ba4\u77e5\u7ec8\u70b9\u6709\u88e8\u76ca\u3002\u201d<\/span><\/p>\n

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Kasimov\u6307\u51fa\u201c\u7279\u522b\u75db\u70b9\u201d\u5728\u4e8e\u975eAPOE4\u7a81\u53d8\u7684\u4e9a\u7ec4\u4e2d\uff0c\u4e34\u5e8a\u75f4\u5446\u5206\u7ea7\u91cf\u8868(CDR-SB)\u8bc4\u4ef7\u7684\u7ed3\u679c\u663e\u793a\uff0c\u9ad8\u5242\u91cf\u7ec4\u6bd4\u5b89\u6170\u5242\u7ec4\u7684\u8868\u73b0\u66f4\u7cdf\u7cd5\u3002\u4ee4\u4eba\u62c5\u5fe7\u539f\u56e0\u6709\u4ee5\u4e0b\u4e24\u70b9\uff1a1)AD\u60a3\u8005\u4e2d\u975eAPOE4\u7a81\u53d8\u8005\u6570\u91cf\u4f9d\u7136\u5de8\u5927\uff1b2)CDR-SB\u662faducanumab III\u671f\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\uff0c\u4e5f\u5c06\u662f\u4eba\u4eec\u5bf9\u4e8eENGAGE\/EMERGE\u8bd5\u9a8c\u6700\u5173\u5fc3\u7684\u5185\u5bb9\u3002<\/span><\/p>\n


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\u672c\u6587\u6458\u81ea\u79d1\u777f\u552f\u5b89\u65b0\u95fb\u8d44\u8bafBioworld Today2018\u5e7410\u670829\u65e5\u671f<\/p>\n

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\u79d1\u777f\u552f\u5b89\u5bf9\u672c\u6587\u7684\u5168\u90e8\u5185\u5bb9\u4ee5\u53ca\u53ef\u80fd\u9644\u5e26\u7684\u5168\u90e8\u8d44\u6599\u62e5\u6709\u5168\u90e8\u77e5\u8bc6\u4ea7\u6743\uff0c\u5e76\u53d7\u6cd5\u5f8b\u4fdd\u62a4\u3002\u7f51\u7edc\u8f6c\u8f7d\u3001\u7f16\u8bd1\u53ca\u5176\u4ed6\u5546\u4e1a\u4f7f\u7528\u8bf7\u8054\u7cfb\u5e02\u573a\u90e8\uff1ayili1@Clarivate.com<\/p>\n

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BioWorld Today<\/strong><\/p>\n<\/section>\n


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\u6bcf\u65e5\u8981\u95fb\u2014\u2014\u5f71\u54cd\u751f\u7269\u6280\u672f\u884c\u4e1a\u672a\u6765\u7684\u91cd\u5927\u65b0\u95fb<\/span><\/strong><\/span><\/h3>\n<\/section>\n<\/section>\n<\/section>\n
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20\u5e74\u884c\u4e1a\u65b0\u95fb\u79ef\u6dc0\uff0c\u5e2e\u52a9\u60a8\u5728\u751f\u7269\u6280\u672f\u4e1a\u52a1\u4e2d\u83b7\u5f97\u66f4\u5927\u7684\u6210\u529f\u3002\u6bcf\u4e2a\u5de5\u4f5c\u65e5\u4e3a\u60a8\u5448\u73b0\u5f71\u54cd\u884c\u4e1a\u672a\u6765\u53d1\u5c55\u7684\u6df1\u5ea6\u62a5\u9053\u5185\u5bb9\u3002\u4e3b\u8981\u5185\u5bb9\u5305\u62ec\uff1a<\/span><\/p>\n


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\u25a0  <\/span>\u6cbb\u7597\u6027\u836f\u54c1\u5f00\u53d1\u4fe1\u606f\uff08\u4ece\u65e9\u671f\u53d1\u73b0\u5230\u4e0a\u5e02\uff09<\/span><\/p>\n

\u25a0  <\/span>\u6218\u7565\u6027\u5408\u4f5c\u3001\u5408\u5e76\u4e0e\u6536\u8d2d<\/span><\/p>\n

\u25a0  <\/span>\u4e0a\u5e02\u516c\u53f8\u548c\u79c1\u8425\u4f01\u4e1a\u7684\u8d44\u91d1\u7b79\u96c6\u4fe1\u606f<\/span><\/p>\n

\u25a0  <\/span>\u5173\u4e8e\u751f\u7269\u6280\u672f\u516c\u53f8\u6b63\u9762\u548c\u8d1f\u9762\u7684\u6d88\u606f<\/span><\/p>\n

\u25a0  <\/span>\u91cd\u5927\u79d1\u5b66\u7a81\u7834<\/span><\/p>\n

\u25a0  <\/span>\u5168\u7403\u836f\u653f\u6cd5\u89c4\u7684\u6700\u65b0\u53d8\u66f4<\/span><\/p>\n

\u25a0  <\/span>\u65b0\u5174\u548c\u6210\u719f\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u4ee5\u53ca\u7279\u8272\u5236\u836f\u516c\u53f8\u7684\u80cc\u666f\u8d44\u6599<\/span><\/p>\n

\u25a0  <\/span>\u5927\u578b\u5236\u836f\u516c\u53f8\u6d89\u8db3\u751f\u7269\u6280\u672f\u9886\u57df\u7684\u6700\u65b0\u62a5\u9053<\/span><\/p>\n


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\u60a8\u8fd8\u53ef\u4ee5\u8ba2\u9605BioWorld Today\u7684\u5f80\u671f\u56de\u6eaf\u5185\u5bb9\uff0c\u900f\u8fc718\u5e74\u6765\u7684\u884c\u4e1a\u65b0\u95fb\u4e0e\u5386\u53f2\u4e8b\u4ef6\uff0c\u83b7\u5f97\u66f4\u52a0\u6df1\u523b\u7684\u89c1\u89e3\u3002\u5185\u5bb9\u56de\u6eaf\u81f31991\u5e74\uff0c\u68c0\u7d22\u65b9\u4fbf\uff0c\u60a8\u53ef\u4ee5\u6d4f\u89c8BioWorld Today\u53d1\u8868\u7684\u6bcf\u7bc7\u6587\u7ae0\uff0c\u975e\u5e38\u9002\u5408\u505a\u516c\u53f8\u548c\u4ea7\u54c1\u7814\u7a76\u3002<\/span>
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\u5982\u679c\u60a8\u8ba2\u9605BioWorld Today\uff0c\u6211\u4eec\u5c06\u514d\u8d39\u8d60\u9001\u5982\u4e0b\u62a5\u544a\uff1a<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/span>\u25a0<\/span> <\/span><\/span>BioWorld Midday Report<\/span><\/strong><\/span><\/p>\n

\u6bcf\u5929\u4e0b\u5348\u9884\u544a\u4e0b\u671fBioWorld Today\u5c06\u8981\u62a5\u9053\u7684\u8bdd\u9898\uff0c\u4ee5email\u7684\u5f62\u5f0f\u53d1\u9001\u7ed9BioWorld Today\u7684\u8ba2\u9605\u7528\u6237\u3002\u53ef\u4ee5\u5e2e\u52a9\u60a8\u5feb\u901f\u9501\u5b9a\u60a8\u9700\u8981\u7acb\u5373\u5173\u6ce8\u7684\u91cd\u5927\u65b0\u95fb\u4e8b\u4ef6\u3002<\/span><\/p>\n

\u25a0<\/span>  <\/span>BioWorld Industry Snapshots<\/span><\/strong><\/span><\/p>\n

\u65e0\u9650\u5236\u514d\u8d39\u8bbf\u95ee\u6570\u636e\u5e93\u4e2d\u7684\u4e0b\u5217\u4fe1\u606f\uff08\u6570\u636e\u53ef\u56de\u6eaf\u81f31999\u5e74\uff09\uff1a<\/span><\/p>\n

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    \u589e\u53d1\u65b0\u80a1<\/span><\/p>\n<\/li>\n

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    \u5e02\u9762\u4e0a\u7684\u4ea7\u54c1\u4fe1\u606f<\/span><\/p>\n<\/li>\n

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    <\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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