{"id":67618,"date":"2018-10-31T01:00:00","date_gmt":"2018-12-07T04:16:34","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/6a0a3789b0\/"},"modified":"2018-12-07T12:16:43","modified_gmt":"2018-12-07T04:16:43","slug":"6a0a3789b0","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/67618\/","title":{"rendered":"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u7279\u7ea6\u4f5c\u8005\uff1a\u9a6c\u4e50\u4f1f<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">2018\u5e7410\u670822\u65e5\uff0cAstraZeneca\u4e0eMerck\u5728\u5fb7\u56fd\u6155\u5c3c\u9ed1\u7684ESMO\u5927\u4f1a\u4e0a\u8054\u5408\u516c\u5e03\u4e86Olaparib\u6700\u65b0\u7684III\u671f\u4e34\u5e8a\u7ed3\u679c\uff0c\u8fd9\u4e00\u79ef\u6781\u7ed3\u679c\u5c06\u4f7fOlaparib\u5728\u5375\u5de2\u764c\u7684\u7ef4\u6301\u6cbb\u7597\u4e2d\u83b7\u4e00\u7ebf\u7528\u836f\u5730\u4f4d\u3002\u4e00\u65f6\u95f4\uff0cPARP\u6291\u5236\u5242\u518d\u5ea6\u6210\u4e3a\u884c\u4e1a\u70ed\u70b9\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">2016\u5e747\u6708\uff0c\u7b14\u8005\u66fe\u64b0\u5199\u8fc7\u4e00\u7bc7\u9898\u4e3a\u300aPARP\u6291\u5236\u5242\u5168\u7403\u7814\u53d1\uff1a\u7ade\u4e89\u6fc0\u70c8\uff0c\u4f46\u5404\u6709\u7279\u8272\u300b\u7684\u6587\u7ae0\u3002\u65f6\u9694\u4e24\u5e74\uff0c\u6211\u4eec\u518d\u6765\u770b\u4e00\u4e0b\u5168\u7403PARP\u6291\u5236\u5242\u7684\u6700\u65b0\u7ade\u4e89\u683c\u5c40\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"display: inline-block;vertical-align: top;background-color: rgb(255, 255, 255);background-image: none;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;padding-right: 5px;color: rgb(104, 23, 255);background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><strong style=\"background-image: none;box-sizing: border-box;\">PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u4f9d\u7136\u6fc0\u70c8<\/strong><\/p>\n<\/section>\n<section style=\"margin-right: 4px;margin-bottom: 4px;display: inline-block;vertical-align: bottom;width: 5px;border-color: rgb(104, 23, 255);border-right: 1px solid rgb(104, 23, 255);border-left: 1px solid rgb(104, 23, 255);height: 8px;transform-origin: center bottom 0px;-webkit-transform-origin: center bottom 0px;-moz-transform-origin: center bottom 0px;-o-transform-origin: center bottom 0px;transform: skew(-30deg);-webkit-transform: skew(-30deg);-moz-transform: skew(-30deg);-o-transform: skew(-30deg);background-image: none;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"height: 12px;margin-top: -12px;border-top: 1px solid rgb(104, 23, 255);background-image: none;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u5168\u7403\u5904\u4e8e\u6d3b\u8dc3\u72b6\u6001\u7684PARP\u6291\u5236\u5242\u517143\u4e2a\u3002\u5176\u4e2d\u5df2\u4e0a\u5e023\u4e2a\uff0c\u5b8c\u6210\u6ce8\u518c1\u4e2a\u3001III\u671f2\u4e2a\uff0cII\u671f6\u4e2a\uff0cI\u671f\u76848\u4e2a\uff0c\u5904\u4e8e\u4e34\u5e8a\u524d\u768423\u4e2a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/1-1544156195.png\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\">Source\uff1aClarivate Analytics Cortellis Competitive Intelligence\uff08\u622a\u6b622018\/10\/29\uff09<\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\">*\uff1a Talazoparib\uff08Pfizer\uff09\u4e8e2018\u5e7410\u670817\u65e5\u83b7FDA\u6279\u51c6<\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\"><br style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u4ece\u5730\u57df\u5206\u5e03\u6765\u770b\uff0c\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u97e9\u56fd\u3001\u82f1\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u4f4d\u5c45\u524d\u4e94\u3002\u5176\u4e2d\uff0c\u4e2d\u56fd\u4ee518\u4e2a\u7684\u6570\u91cf\u4f4d\u5c45\u5168\u7403\u7b2c\u4e00\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/8-1544156195.jpg\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\">Source\uff1aClarivate Analytics Cortellis Competitive Intelligence\uff08\u622a\u6b622018\/10\/29\uff09<\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\"><br style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u4ece\u4e2d\u7f8e\u4e24\u56fd\u7684PARP\u6291\u5236\u5242\u6240\u5904\u7684\u9636\u6bb5\u60c5\u51b5\u770b\uff0c\u7f8e\u56fd\u5904\u4e8e\u5f00\u53d1\u540e\u7aef\u7684\u4ea7\u54c1\u6570\u91cf\u8f83\u591a\uff08\u83b7\u6279\u6570\u91cf\uff0c\u7f8e\u56fd4 Vs. \u4e2d\u56fd1\uff09\uff0c\u800c\u4e2d\u56fd\u5904\u4e8e\u5f00\u53d1\u524d\u7aef\u7684\u5360\u6bd4\u8f83\u5927\uff08I\u671f\u53ca\u4e4b\u524d\u6570\u91cf\uff0c\u4e2d\u56fd16 Vs. \u7f8e\u56fd14\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/3-1544156196.png\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\">Source\uff1aClarivate Analytics Cortellis Competitive Intelligence\uff08\u622a\u6b622018\/10\/29\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"text-align: center;background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u5168\u7403PARP\u6291\u5236\u5242Pipline\uff08\u90e8\u5206\uff09<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/1-1544156196.jpg\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\">Source\uff1aClarivate Analytics Cortellis Competitive Intelligence\uff08\u622a\u6b622018\/10\/29\uff09<\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\"><br style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"display: inline-block;vertical-align: top;background-color: rgb(255, 255, 255);background-image: none;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;padding-right: 5px;color: rgb(104, 23, 255);background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><strong style=\"background-image: none;box-sizing: border-box;\">Olaparib: \u540d\u526f\u5176\u5b9e\u7684First-in-class<\/strong><\/p>\n<\/section>\n<section style=\"margin-right: 4px;margin-bottom: 4px;display: inline-block;vertical-align: bottom;width: 5px;border-color: rgb(104, 23, 255);border-right: 1px solid rgb(104, 23, 255);border-left: 1px solid rgb(104, 23, 255);height: 8px;transform-origin: center bottom 0px;-webkit-transform-origin: center bottom 0px;-moz-transform-origin: center bottom 0px;-o-transform-origin: center bottom 0px;transform: skew(-30deg);-webkit-transform: skew(-30deg);-moz-transform: skew(-30deg);-o-transform: skew(-30deg);background-image: none;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"height: 12px;margin-top: -12px;border-top: 1px solid rgb(104, 23, 255);background-image: none;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">AstraZeneca\uff08\u4ee5\u4e0b\u7b80\u79f0AZ\uff09\u7684Olaparib\u53ef\u8c13\u662f\u8be5\u9886\u57df\u540d\u526f\u5176\u5b9e\u7684First-in-class\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">2014\u5e7412\u670819\u65e5\uff0cOlaparib\u4ee5II\u671f\u4e34\u5e8a\u6570\u636e\u83b7FDA\u6279\u51c6\uff0c\u7528\u4e8e\u5375\u5de2\u764c\u7684\u6cbb\u7597\u3002\u968f\u540e\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u4e0d\u65ad\u5728\u4e73\u817a\u764c\u3001\u80f0\u817a\u764c\u3001\u80c3\u764c\u7b49\u9886\u57df\u5f00\u5c55\u3002\u622a\u81f3\u76ee\u524d\uff0cOlaparib\u5728\u5375\u5de2\u764c\u548c\u4e73\u817a\u764c\u4e24\u4e2a\u9886\u57df\u4e2d\u5747\u83b7\u6279\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u6574\u4f53\u6765\u770b\uff0cOlaparib\u7684\u53d1\u5c55\u53ca\u83b7\u6279\u8def\u5f84\u5982\u4e0b\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/6-1544156197.jpg\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">Olaparib\u5728<strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u5375\u5de2\u764c\u9886\u57df<\/span><\/strong>\u7684\u53d1\u5c55\u8def\u5f84\uff0c\u4ece\u4fa7\u9762\u4f53\u73b0\u4e86AZ\u7684\u4e0a\u5e02\u7b56\u7565\uff1a\u5148\u4ee5\u56db\u7ebf\u4e0a\u5e02\uff0c\u518d\u9010\u6b65\u5411\u4e8c\u7ebf\u548c\u4e00\u7ebf\u62d3\u5c55\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u800c\u8fd9\u201c\u59d4\u66f2\u6c42\u5168\u201d\u7684\u7b56\u7565\u80cc\u540e\uff0c\u4e0eOlaparib\u65e9\u671f\u7684\u4e34\u5e8a\u6570\u636e\u606f\u606f\u76f8\u5173\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"background-image: none;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"background-color: rgba(1, 0, 0, 0);font-size: 14px;text-align: justify;\">1.AZ\u65e9\u671f\u5f00\u53d1\u7684\u76ee\u6807\u9002\u5e94\u75c7\u662f\u4e09\u9634\u4e73\u817a\u764c\uff0c\u5728\u76f8\u5173II\u671f\u4e34\u5e8a\u8bc1\u660e\u8be5\u836f\u5728\u4e09\u9634\u6027\u4e73\u817a\u764c\u60a3\u8005\u4eba\u7fa4\u4e2d\u51e0\u4e4e\u65e0\u5e94\u7b54\u540e\uff0c\u624d\u5c06\u5176\u91cd\u5fc3\u9650\u5b9a\u5728gBRCA\u7a81\u53d8\u7684\u4e73\u817a\u764c\u53ca\u5176\u65b0\u8f85\u52a9\u6cbb\u7597\u4e0a\u3002<\/span><\/p>\n<p style=\"background-image: none;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"background-color: rgba(1, 0, 0, 0);font-size: 14px;text-align: justify;\"><br \/><\/span><\/p>\n<p style=\"background-image: none;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"background-color: rgba(1, 0, 0, 0);font-size: 14px;text-align: justify;\">2.&nbsp;<\/span><span style=\"background-color: rgba(1, 0, 0, 0);color: rgb(5, 5, 5);font-size: 14px;text-align: justify;\">AZ\u5728\u65b0\u7684\u7814\u53d1\u91cd\u5fc3\u4e0a\u5e76\u975e\u4e00\u5e06\u98ce\u987a\u30022014\u5e742\u6708\uff0cAZ\u63d0\u4ea4\u4e86\u8be5\u836f\u7528\u4e8e\u94c2\u7c7b\u6cbb\u7597\u590d\u53d1\u7684gBRCA\u7a81\u53d8\u5375\u5de2\u764c\u7ef4\u6301\u6cbb\u7597\u7684\u4e0a\u5e02\u7533\u8bf7\u30022014\u5e746\u6708\uff0cFDA\u5bf9\u8be5\u836f\u7597\u6548\u7684\u53ef\u9760\u6027\u63d0\u51fa\u8d28\u7591\u3002\u6700\u7ec8\uff0cFDA\u80bf\u7624\u836f\u7269\u54a8\u8be2\u59d4\u5458\u4f1a (Oncologic Drugs Advisory Committee\uff0cODAC) \u4ee511:2\u7684\u6295\u7968\u7ed3\u679c\u53cd\u5bf9Olaparib\u7684\u52a0\u901f\u6279\u51c6\u3002<\/span><\/p>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u968f\u540e\uff0cAZ\u62ff\u51fa\u4e86\u4e00\u4e2a\u6bd4\u8f83\u5173\u952e\u7684II\u671f\u4e34\u5e8a\u6570\u636e\uff08NCT01078662\uff09\uff1a\u5bf9\u4e8e\u90a3\u4e9b\u5df2\u63a5\u53d7\u4e09\u79cd\u6216\u66f4\u591a\u5316\u7597\u65b9\u6848\u6cbb\u7597\u7684gBRCA\u7a81\u53d8\u7684\u5375\u5de2\u764c\u60a3\u8005\uff0cOlaparib\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a34%\uff1b\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u662f7.9\u4e2a\u6708\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u53c2\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\u768434%\u7684\u60a3\u8005\u5e73\u5747\u67097.9 \u4e2a\u6708\u7684 ORR\u3002\u8bf4\u5b9e\u8bdd\uff0c\u6570\u636e\u5e76\u4e0d\u662f\u5f88\u6f02\u4eae\uff0c\u4f46\u57fa\u4e8e\u8be5\u6570\u636e\uff0cOlaparib\u6210\u4e86\u5168\u7403\u7b2c\u4e00\u4e2a\u4e0a\u5e02\u7684PARP\u6291\u5236\u5242\u3002<\/p>\n<p style=\"text-align: center;background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">Olaparib\u65e9\u671f\u7684\u6709\u6548\u6027<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/1-1544156197.jpg\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"text-align: left;background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\">Source\uff1aFDA<\/span><\/p>\n<p style=\"text-align: left;background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\"><br \/><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 14px;\">3. \u5e78\u8fd0\u7684\u662f\uff0cSOLO1\u3001SOLO2\u548cStudy19\u4e09\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u6bd4\u8f83\u7ed9\u529b\u3002<\/span><\/p>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u9996\u5148\u662fSOLO2\u8bd5\u9a8c\uff0c295\u540d<strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">gBRCA\u7a81\u53d8<\/span><\/strong>\u7684\u590d\u53d1\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u3001\u6216\u662f\u539f\u53d1\u6027\u8179\u819c\u764c\u60a3\u8005\u5728\u94c2\u7c7b\u5316\u7597\u540e\u7684\u7f13\u89e3\u671f\u5185\u5206\u522b\u91c7\u7528Olaparib\u6216\u5b89\u6170\u5242\u7ef4\u6301\u6cbb\u7597\uff0c\u63a5\u53d7Olaparib\u6cbb\u7597\u7684\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a19.1\u4e2a\u6708\uff0c\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\u60a3\u8005\u76845.5\u4e2a\u6708\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">Study 19\u8bd5\u9a8c\u8fdb\u4e00\u6b65\u8bc1\u660e\u5728<strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">gBRCA\u65e0\u7a81\u53d8<\/span><\/strong>\u7684\u540c\u7c7b\u60a3\u8005\u7fa4\u4f53\u4e2d\uff0cOlaparib\u7ec4\u7684PFS\u4e3a11.2\u4e2a\u6708\uff0c\u660e\u663e\u9ad8\u4e8e\u5bf9\u7167\u7ec44.2\u4e2a\u6708\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">SOLO2\u548cStudy19\u4e24\u4e2a\u8bd5\u9a8c\u8bc1\u660e\uff0c\u65e0\u8bba\u60a3\u8005\u662f\u5426gBRCA\u7a81\u53d8\uff0cOlaparib\u5747\u53ef\u7528\u4e8e\u5bf9\u94c2\u57fa\u5316\u7597\u6709\u53cd\u5e94\u7684\u5375\u5de2\u764c\u7684\u7ef4\u6301\u6cbb\u7597\u3002<strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u8fd9\u4e00\u9002\u5e94\u75c7\u7684\u62d3\u5c55\u5bf9Olaparib\u6765\u8bf4\u6781\u5176\u91cd\u8981\uff0c\u5b83\u4f7fOlaparib\u5728\u5375\u5de2\u764c\u7684\u6cbb\u7597\uff0c\u4ece\u201c\u56db\u7ebf\u201d\u4e00\u8dc3\u8fdb\u5165\u201c\u4e8c\u7ebf\u201d\u3002<\/span><\/strong><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/span><\/strong><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u7b2c\u4e09\u4e2a\u8bd5\u9a8c\u662fSOLO1\u8bd5\u9a8c\uff08\u4e5f\u5c31\u662f\u5f00\u5934\u63d0\u5230\u7684\u91cd\u78c5\u8bd5\u9a8c\uff09 \u30022018\u5e7410\u670822\u65e5\u516c\u5f00\u7684\u6570\u636e\u663e\u793a: Olaparib\u4f5c\u4e3a\u7ef4\u6301\u7597\u6cd5\uff0c\u80fd\u591f\u5c06gBRCA\u7a81\u53d8\u7684\u665a\u671f\u5375\u5de2\u764c\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8670%\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/10-1544156198.jpg\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\">Source:Moore K, Colombo N, Scambia G, et al. Maintenance olaparib in patients with newly diagnosed advanced ovarian cancer. N Engl J Med.<\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\"><br style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u57fa\u4e8e\u8be5\u6570\u636e\uff0cAZ\u4e0eMerck\u5df2\u7ecf\u542f\u52a8\u8be5\u9002\u5e94\u75c7\u7684\u8865\u5145\u7533\u8bf7\u3002\u81f3\u6b64\uff0c<strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">Olaparib\u5728\u5375\u5de2\u764c\u9886\u57df\uff0c\u59a5\u59a5\u7684\u4ece\u201c\u4e8c\u7ebf\u201d\u633a\u8fdb\u4e86\u201c\u4e00\u7ebf\u201d\u3002<\/span><\/strong><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/span><\/strong><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u5728<strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u4e73\u817a\u764c\u9886\u57df<\/span><\/strong>\uff0cOlympiAD\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u660e\uff0c\u4e0e\u5316\u7597\u7ec4\u76f8\u6bd4\uff0cOlaparib\u663e\u8457\u5ef6\u957f\u4e86\u60a3\u8005\u7684PFS\uff08\u4e2d\u4f4d7.0 vs 4.2\u4e2a\u6708\uff09\uff0c\u5c06\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8642\uff05\u3002\u57fa\u4e8e\u8be5\u6570\u636e\uff0c2018\u5e741\u6708\u4efd\uff0cFDA\u6279\u51c6\u8be5\u836f\u7528\u4e8egBRCA\u7a81\u53d8\u7684HER2-\u9634\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u6cbb\u7597\u3002Olaparib\u4e5f\u6210\u4e86<strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">FDA\u6279\u51c6\u7684\u7b2c\u4e00\u4e2a\u7528\u4e8egBRCA\u7a81\u53d8\u578b\u4e73\u817a\u764c\u7684PARP\u6291<\/span><\/strong><strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u5236\u5242\u3002<\/span><\/strong><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u9664\u4e86\u5375\u5de2\u764c\u548c\u4e73\u817a\u764c\u5916\uff0cAZ\u9488\u5bf9\u5176\u4ed6\u9002\u5e94\u75c7\u7684\u62d3\u5c55\u4e5f\u5728\u79ef\u6781\u8fdb\u884c\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/7-1544156198.jpg\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u636e\u79d1\u777f\u552f\u5b89Clinical Trials Intelligence\u7edf\u8ba1\uff0c\u9488\u5bf9Olaparib\uff0cAZ\u5728\u5168\u7403\u540c\u65f6\u5f00\u5c55\u4e86206\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/2-1544156199.png\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\">Source\uff1aClarivate Analytics Cortellis Clinical Trials Intelligence\uff08\u622a\u6b622018\/10\/29\uff09<\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\"><br style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u7b14\u8005\u4e0d\u7981\u611f\u53f9\uff0c\u4e5f\u53ea\u6709\u8fd9\u79cdBig Pharma\u80fd\u540c\u6b65\u5f00\u5c55\u5982\u6b64\u591a\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u4ed4\u7ec6\u770b\u770b\u8fd9\u4e9b\u9002\u5e94\u75c7\uff0c\u90fd\u4e0d\u5bb9\u5c0f\u89d1\uff0c\u96be\u602a\u6295\u8d44\u8005\u9884\u6d4bOlaparib\u57282022\u5e74\u7684\u5168\u7403\u9500\u552e\u989d\u5c06\u7a81\u783423.88\u4ebf\u7f8e\u91d1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/7-1544156199.jpg\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\">Source\uff1aClarivate Analytics Cortellis Competitive Intelligence\uff08\u622a\u6b622018\/10\/29\uff09<\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\"><br style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"display: inline-block;vertical-align: top;background-color: rgb(255, 255, 255);background-image: none;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;padding-right: 5px;color: rgb(104, 23, 255);background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><strong style=\"background-image: none;box-sizing: border-box;\">Niraparib: \u5982\u613f\u4ee5\u507f\u7684\u201c\u9ed1\u9a6c\u201d<\/strong><\/p>\n<\/section>\n<section style=\"margin-right: 4px;margin-bottom: 4px;display: inline-block;vertical-align: bottom;width: 5px;border-color: rgb(104, 23, 255);border-right: 1px solid rgb(104, 23, 255);border-left: 1px solid rgb(104, 23, 255);height: 8px;transform-origin: center bottom 0px;-webkit-transform-origin: center bottom 0px;-moz-transform-origin: center bottom 0px;-o-transform-origin: center bottom 0px;transform: skew(-30deg);-webkit-transform: skew(-30deg);-moz-transform: skew(-30deg);-o-transform: skew(-30deg);background-image: none;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"height: 12px;margin-top: -12px;border-top: 1px solid rgb(104, 23, 255);background-image: none;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u8fd8\u8bb0\u5f972016\u5e74\u7684\u590f\u5929\uff0c\u5f53AZ\u6709\u6761\u4e0d\u7d0a\u7684\u6267\u884c\u7740Olaparib\u7684\u5f00\u53d1\u7b56\u7565\u65f6\uff0cNiraparib\u4ee5\u8fc5\u96f7\u4e0d\u53ca\u63a9\u8033\u7684\u901f\u5ea6\u706b\u904d\u5168\u7403\uff0c\u6210\u4e86\u5f53\u65f6\u6700\u5f15\u4eba\u77a9\u76ee\u7684\u201c\u9ed1\u9a6c\u201d\uff1aTesaro\u516c\u5e03III\u671f\u4e34\u5e8a\u6570\u636e\u7684\u5f53\u5929\u80a1\u7968\u66b4\u6da8108%\uff0c\u5e02\u503c\u4ece17.06\u4ebf\u7f8e\u91d1\u98d9\u5347\u81f335.48\u4ebf\u7f8e\u91d1\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u5f53\u5e74\u5728\u5375\u5de2\u764c\u4e8c\u7ebf\u6cbb\u7597\u9886\u57df\u8fdb\u5c55\u6700\u5feb\u7684Niraparib\uff0c\u5982\u4eca\u4e5f\u5982\u613f\u4ee5\u507f\u5730\u5b9e\u73b0\u4e86\u201c<strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u5168\u7403\u7b2c\u4e00\u4e2a\u7528\u4e8e\u5375\u5de2\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684PARP\u6291\u5236\u5242<\/span><\/strong>\u201d\u7684\u68a6\u60f3\uff1a2017\u5e743\u6708\u83b7FDA\u6279\u51c6\uff0c\u7528\u4e8e\u5bf9\u94c2\u57fa\u5316\u7597\u6709\u5b8c\u5168\u6216\u90e8\u5206\u53cd\u5e94\u7684\u6210\u4eba\u590d\u53d1\u6027\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u7684\u7ef4\u6301\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/3-1544156200.jpg\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u4ece\u83b7\u6279\u65f6\u95f4\u6765\u770b\uff0cNiraparib\u6bd4Olaparib\u5728\u5375\u5de2\u764c\u4e8c\u7ebf\u6cbb\u7597\u4e0a\u63d0\u524d\u83b7\u6279\u4e866\u4e2a\u6708\u3002\u4ece\u5bf9\u6bd4\u6570\u636e\u6765\u770b\uff0cNiraparib \u5bf9gBRCA\u7a81\u53d8\u7684\u5375\u5de2\u764c\u66f4\u6709\u4f18\u52bf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/3-1544156200.png\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\">Source\uff1aFDA<\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\"><br style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u5f97\u76ca\u4e8e\u4ee5\u4e0a\u4f18\u52bf\uff0c<strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">Niraparib\u5728\u4e0a\u5e02\u540e\u77ed\u77ed\u76843\u4e2a\u6708\u5185\u6210\u4e3a\u7f8e\u56fd\u533b\u836f\u5e02\u573a\u4e0a\u5904\u65b9\u91cf\u6700\u5927\u7684PARP\u6291\u5236\u5242<\/span><\/strong>\u3002\u5206\u6790\u5e08\u9884\u6d4b\uff0c\u8be5\u836f 2024\u5e74\u5c06\u7a81\u78349.4\u4ebf\u7f8e\u91d1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/1-1544156201.jpg\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\">Source\uff1aClarivate Analytics Cortellis Competitive Intelligence\uff08\u622a\u6b622018\/10\/29\uff09<\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"font-size: 12px;background-image: none;box-sizing: border-box;\"><br style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u76f8\u8f83\u4e8eOlaparib\uff0cNiraparib\u4e00\u5f00\u59cb\u5c31\u4ee5\u4e8c\u7ebf\u7528\u836f\u83b7\u6279\uff0c\u8fd9\u4e00\u70b9\u8981\u6bd4Olaparib\u5e78\u8fd0\u7684\u591a\u3002\u4f46\u5728\u5375\u5de2\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u7814\u53d1\u8fdb\u5ea6\u4e0a\uff0c2016\u5e744\u6708\u624d\u542f\u52a8III\u671f\u4e34\u5e8a\u7684Niraparib\uff0c\u4e0e2013\u5e749\u6708\u5c31\u5df2\u7ecf\u542f\u52a8III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u5728\u8fd1\u671f\u5c31\u5df2\u83b7\u5f97\u79ef\u6781\u4e34\u5e8a\u7ed3\u679c\u7684Olaparib\u76f8\u6bd4\uff0c\u8fdb\u5ea6\u7740\u5b9e\u6162\u4e86\u4e0d\u5c11\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/8-1544156201.jpg\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u6b64\u5916\uff0cNiraparib\u5728\u5168\u7403\u6743\u76ca\u7684\u4ea4\u6613\u65b9\u9762\u4e5f\u975e\u5e38\u6709\u610f\u601d\uff0cNiraparib\u6700\u65e9\u5c5e\u4e8eMerck\uff0c\u4ece2008\u5e749\u6708\u5f00\u59cb\uff0cMerck\u62ff\u7740\u8be5\u5316\u5408\u7269\u5148\u540e\u5728\u5375\u5de2\u764c\u3001\u8840\u6db2\u80bf\u7624\u3001\u6076\u6027\u6dcb\u5df4\u7624\u3001\u80f6\u8d28\u7624\u53ca\u9ed1\u8272\u7d20\u7624\u7b49\u9886\u57df\u6298\u817e\u4e86\u8fd14\u5e74\u3002\u5728\u5bf9\u5176\u5931\u671b\u4e4b\u540e\uff0c\u4e8e2012\u5e745\u6708\u5c06\u8be5\u836f\u72ec\u5bb6\u6388\u6743\u7ed9Tesaro\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">Tesaro\u62ff\u5230Niraparib\u540e\uff0c\u5206\u522b\u5728\u5375\u5de2\u764c\u3001\u4e73\u817a\u764c\u3001\u5c24\u56e0\u8089\u7624\u7b49\u9886\u57df\u5f00\u5c55\u4e86\u8fdb\u4e00\u6b65\u7814\u7a76\u3002\u81ea2016\u5e74\u83b7\u5f97\u79ef\u6781\u7684III\u671f\u4e34\u5e8a\u6570\u636e\u4e4b\u540e\uff0cTesaro\u5f00\u59cb\u5728\u5168\u7403\u8303\u56f4\u5185\u8f6c\u8ba9Niraparib\u7684\u533a\u57df\u6027\u6743\u76ca\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/2-1544156201.jpg\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u5728\u4e2d\u56fd\uff0c\u518d\u9f0e\u4e8e2017\u5e747\u6708\u5411CFDA\u63d0\u4ea4\u4e86Niraparib\uff08ZL-2306\uff09\u7684IND\u7533\u8bf7\uff0c\u622a\u81f3\u76ee\u524d\uff0c\u5df2\u5c06ZL-2306\u5728\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u4e8c\u7ebf\u5375\u5de2\u764c\u3001\u4e00\u7ebf\u5375\u5de2\u764c\u4e09\u4e2a\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u63a8\u5411\u4e86III\u671f\uff0c\u76ee\u524d\u5747\u5904\u4e8e\u62db\u52df\u4e2d\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u5168\u7403\u8303\u56f4\u5185\u7684\u9002\u5e94\u75c7\u62d3\u5c55\u65b9\u9762\uff0c\u9664\u5375\u5de2\u764c\u5916\uff0cTesaro\u8fd8\u540c\u65f6\u5f00\u5c55\u4e86Niraparib\u5728\u4e73\u817a\u764c\u3001\u80ba\u764c\u7684III\u671f\u4e34\u5e8a\u3002\u8fd9\u4e9b\u9886\u57df\u80fd\u5426\u201c\u9006\u88ad\u201d\uff0c\u53ea\u80fd\u4ea4\u7ed9\u65f6\u95f4\u4e86\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/0-1544156202.jpg\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"display: inline-block;vertical-align: top;background-color: rgb(255, 255, 255);background-image: none;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;padding-right: 5px;color: rgb(104, 23, 255);background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><strong style=\"background-image: none;box-sizing: border-box;\">\u5176\u4ed6\u836f\u7269\u7684\u5f00\u53d1\u60c5\u51b5&nbsp;<\/strong><\/p>\n<\/section>\n<section style=\"margin-right: 4px;margin-bottom: 4px;display: inline-block;vertical-align: bottom;width: 5px;border-color: rgb(104, 23, 255);border-right: 1px solid rgb(104, 23, 255);border-left: 1px solid rgb(104, 23, 255);height: 8px;transform-origin: center bottom 0px;-webkit-transform-origin: center bottom 0px;-moz-transform-origin: center bottom 0px;-o-transform-origin: center bottom 0px;transform: skew(-30deg);-webkit-transform: skew(-30deg);-moz-transform: skew(-30deg);-o-transform: skew(-30deg);background-image: none;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"height: 12px;margin-top: -12px;border-top: 1px solid rgb(104, 23, 255);background-image: none;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">Clovis\u7684Rucaparib\u662f\u201c\u5168\u7403\u7b2c\u4e00\u4e2a\u7528\u4e8e\u5375\u5de2\u764c\u4e09\u7ebf\u6cbb\u7597\u7684 PARP\u6291\u5236\u5242\u201d\u3002<\/span><\/strong>\u8be5\u836f\u6700\u521d\u5c5e\u4e8ePfizer\u3002\u4e0eMerck\u7c7b\u4f3c\uff0c\u5728\u7ecf\u53d7\u51e0\u6b21\u4e34\u5e8a\u5931\u8d25\u540e\u5bf9PARP\u6291\u5236\u5242\u5931\u53bb\u8010\u5fc3\uff0c\u5e76\u4e8e2011\u5e746\u6708\u5c06Rucaparib\u72ec\u5bb6\u6388\u6743\u7ed9Clovis\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u7ecf\u8fc7Clovis\u4e94\u5e74\u534a\u7684\u52aa\u529b\uff0cRucaparib\u7ec8\u4e8e\u57282016\u5e7412\u6708\u83b7FDA\u6279\u51c6\uff0c\u7528\u4e8egBRCA\u7a81\u53d8\u7684\u5375\u5de2\u764c\u7684\u4e09\u7ebf\u6cbb\u7597\u3002<strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">2018\u5e744\u6708\uff0c\u53c8\u83b7FDA\u6279\u51c6\u7528\u4e8e\u5375\u5de2\u764c\u7684\u4e8c\u7ebf\u6cbb\u7597<\/span><\/strong>\uff1a\u7528\u4e8e\u5bf9\u94c2\u57fa\u5316\u7597\u6709\u5b8c\u5168\u6216\u90e8\u5206\u53cd\u5e94\u7684\u6210\u4eba\u590d\u53d1\u6027\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u7684\u7ef4\u6301\u6cbb\u7597\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">Rucaparib\u4e0eOlaparib\u7684\u4e0a\u5e02\u7b56\u7565\u5982\u51fa\u4e00\u8f99\uff1a\u90fd\u5148\u5728\u56db\u7ebf\u6216\u4e09\u7ebf\u83b7\u6279\uff0c\u518d\u5411\u5e02\u573a\u66f4\u5e7f\u9614\u7684\u4e8c\u7ebf\u63a8\u8fdb\u3002\u4e0d\u8fc7\uff0cRucaparib\u4e8c\u7ebf\u83b7\u6279\u7684\u65f6\u95f4\u6bd4Niraparib\u548cOlaparib\u90fd\u665a\uff0c\u4ece\u5bf9\u6bd4\u6570\u636e\u6765\u770b\uff0c\u4e34\u5e8a\u4e5f\u4e0d\u5360\u4f18\u52bf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/4-1544156202.png\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u9664\u56fa\u4f53\u5236\u5242\u5916\uff0cClovis\u8fd8\u5f00\u53d1\u4e86\u8be5\u836f\u7684\u9759\u8109\u6ce8\u5c04\u5242\uff0c\u4e3b\u8981\u76ee\u6807\u9002\u5e94\u75c7\u4e3a\u4e09\u9634\u4e73\u817a\u764c\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u3002\u4ece2015\u5e74\u516c\u5e03\u7684II\u671f\u4e34\u5e8a\u7ed3\u679c\u6765\u770b\uff0c\u8be5\u836f\u4e0e\u987a\u94c2\u8054\u7528\u540e\u5bf9\u4e73\u817a\u764c\u7684\u7597\u6548\u53ca\u5b89\u5168\u6027\u4e0e\u987a\u94c2\u5355\u7528\u76f8\u6bd4\u51e0\u4e4e\u6ca1\u6709\u6539\u5584\uff081\u5e74DFS&nbsp;\u201cdisease&nbsp;free&nbsp;survival rate\u201d\uff1a82.7% VS 82.5%\uff09\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">Talazoparib\u636e\u8bf4\u662f\u201c\u6700\u5f3a\u6548\u201d\u7684PARP\u6291\u5236\u5242<\/span><\/strong>\uff08\u4f53\u5916\u6d3b\u6027\u4e3a\u540c\u7c7b\u5316\u5408\u7269\u76842-10\u500d\uff09\u30022015\u5e748\u6708\uff0cMedivation\u4ece&nbsp;BioMarin\u624b\u91cc\u4ee54.1\u4ebf\u7f8e\u91d1\u9884\u4ed8\u6b3e\u52a0\u4e0a1.6\u4ebf\u7f8e\u91d1\u91cc\u7a0b\u7891\u7684\u4ee3\u4ef7\u4e70\u65ad\u4e86Talazoparib\u30022016\u5e748\u6708\uff0cPfizer\u6536\u8d2dMedivation\u540e\u5c06Talazoparib\u7eb3\u5165\u9ebe\u4e0b\uff0c\u5e76\u7ee7\u7eed\u63a8\u8fdb\u8be5\u836f\u5728gBRCA\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684III\u671f\u4e34\u5e8a\u30022017\u5e7412\u4e2a\u516c\u5e03\u7684\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\uff08EMBRACA\uff09\u6570\u636e\u663e\u793a\uff1a\u4e0e\u5316\u7597\u7ec4\u76f8\u6bd4\uff0cTalazoparib\u663e\u8457\u5ef6\u957f\u4e86\u60a3\u8005\u7684PFS\uff08\u4e2d\u4f4d8.6 vs 5.6\u4e2a\u6708\uff09\uff0c\u5c06\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8646\uff05\u3002\u57fa\u4e8e\u8be5\u6570\u636e\uff0c2018\u5e7410\u6708\uff0cFDA\u6279\u51c6\u8be5\u836f\u7528\u4e8egBRCA\u7a81\u53d8\u7684HER2-\u9634\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u6cbb\u7597\uff0c<strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">Talazoparib\u4e5f\u6210\u4e86FDA\u6279\u51c6\u7684\u7b2c\u4e8c\u4e2a\u7528\u4e8egBRCA\u7a81\u53d8\u578b\u4e73\u817a\u764c\u7684PARP\u6291\u5236\u5242\u3002<\/span><\/strong><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/span><\/strong><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u4e0eOlaparib\u76f8\u6bd4\uff0c\u4ece\u83b7\u6279\u65f6\u95f4\u6765\u770b\uff0cTalazoparib\u665a\u4e869\u4e2a\u6708\u3002\u4f46\u4e34\u5e8a\u6570\u636e\u7565\u5360\u4f18\u52bf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/5-1544156203.png\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u9664\u4e73\u817a\u764c\u4e4b\u5916\uff0c Pfizer\u8fd8\u542f\u52a8\u4e86Talazoparib \u7528\u4e8e\u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c(mCRPC)\u4e00\u7ebf\u53ca\u4e8c\u7ebf\u7528\u836f\u7684III\u671f\u4e34\u5e8a\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u76f8\u8f83\u4e8eOlaparib\u3001Niraparib\u3001Rucaparib\u548cTalazoparib\u5728\u5375\u5de2\u764c\u548c\u4e73\u817a\u764c\u4e0a\u7684\u201c\u6b7b\u78d5\u201d\uff0cAbbVie\u7684Veliparib\u8d70\u4e86\u4e00\u6761\u4e0e\u4f17\u4e0d\u540c\u7684\u9053\u8def\uff1a\u4e3b\u653b\u4e73\u817a\u764c\u548cNSCLC\u3002<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/10-1544156203.jpg\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u9057\u61be\u7684\u662f\uff0c2017\u5e744\u6708\u4efdAbbive\u516c\u5e03\u7684\u6570\u636e\u663e\u793a\uff1aVeliparib\u5728\u4e09\u9634\u4e73\u817a\u764c\u4ee5\u53caNSCLC\u7684\u4e24\u4e2aIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5747\u672a\u8fbe\u5230\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">Veliparib\u8fd9\u4e2a\u5728NSCLC\u4e0a\u8d70\u7684\u6700\u5feb\u7684PARP\u6291\u5236\u5242\uff0c\u80fd\u5426\u201c\u5cf0\u56de\u8def\u8f6c\u201d\u6210\u4e3a\u5168\u7403\u7b2c\u4e00\u4e2a\u7528\u4e8eNSCLC\u7684PARP\u6291\u5236\u5242\uff0c\u6211\u4eec\u53ea\u80fd\u5bc4\u5e0c\u671b\u4e8e\u540e\u671f\u7684III\u671f\u4e34\u5e8a\u6570\u636e\u4e86\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u622a\u81f3\u76ee\u524d\uff0c\u56fd\u5185\u4e0a\u5e02\u7684PARP\u6291\u5236\u5242\u53ea\u6709Olaparib\u3002<\/span><\/strong>\u8be5\u836f\u4e8e2014\u5e749\u6708\u83b7\u6279\u4e34\u5e8a\u30022017 \u5e74 12 \u6708\uff0c\u8fdb\u53e3\u4e0a\u5e02\u7533\u8bf7\u83b7CDE\u53d7\u7406\u30022018 \u5e74 1 \u6708\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff08\u4e0e\u73b0\u6709\u6cbb\u7597\u624b\u6bb5\u76f8\u6bd4\u5177\u6709\u660e\u663e\u6cbb\u7597\u4f18\u52bf\uff09\u30022018\u5e748\u6708\u83b7\u6279\uff0c\u7528\u4e8e\u94c2\u654f\u611f\u7684\u590d\u53d1\u6027\u5375\u5de2\u764c\u7684\u7ef4\u6301\u6cbb\u7597\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u4e73\u817a\u764c\u5728\u4e2d\u56fd\u4e5f\u5df2\u8fdb\u5165\u4e86III\u671f\u4e34\u5e8a\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(26, 198, 4);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u9664Olaparib\u4e4b\u5916\uff0c\u518d\u9f0e\u7684Niraparib\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u7684Pamiparib\u8fdb\u5c55\u6700\u5feb\uff0c\u76ee\u524d\u5747\u5904\u4e8eIII\u671f\u3002<\/span><\/strong>\u5728\u7b14\u8005\u770b\u6765\uff0c\u4e24\u5bb6\u516c\u53f8\u5404\u6709\u4f18\u52bf\uff1a<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"background-color: rgba(1, 0, 0, 0);\"><br \/><\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"background-color: rgba(1, 0, 0, 0);\">1.\u518d\u9f0e\u64c5\u957f\u4ece\u6d77\u5916\u62ff\u6743\u76ca\uff0c\u5e76\u5728\u56fd\u5185\u5feb\u901f\u4e0a\u5e02\u3002\u76ee\u524d\u5df2\u5c06Niraparib\u5728\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u5375\u5de2\u764c\u4e24\u4e2a\u9886\u57df\u7684\u4e34\u5e8a\u63a8\u5411\u4e86III\u671f\u3002<\/span><span style=\"background-color: rgba(1, 0, 0, 0);color: rgb(5, 5, 5);\">\u767e\u6d4e\u795e\u5dde\u4e3a\u4e13\u6ce8\u4e8e\u80bf\u7624\u836f\u7684\u521b\u65b0\u578b\u516c\u53f8\uff0c\u7814\u53d1\u5b9e\u529b\u4e00\u6d41\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"background-color: rgba(1, 0, 0, 0);\"><br \/><\/span><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><span style=\"background-color: rgba(1, 0, 0, 0);font-size: 14px;\">2. Pamiparib\u5728\u5375\u5de2\u764c\u3001\u80c3\u764c\u548c\u4e73\u817a\u764c\u4e09\u4e2a\u9886\u57df\u4e2d\u5747\u8fdb\u5165\u4e86III\u671f\u3002<\/span><\/p>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;overflow: hidden;background-image: none;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/8-1544156203.jpg\" alt=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\" title=\"2018\u5e74PARP\u6291\u5236\u5242\u5168\u7403\u7ade\u4e89\u683c\u5c40\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u672a\u6765\u5230\u5e95\u8c01\u80fd\u5750\u4e0a\u56fd\u5185PARP\u6291\u5236\u5242\u7684\u201c\u7b2c\u4e8c\u628a\u4ea4\u6905\u201d\uff0c\u6211\u4eec\u62ed\u76ee\u4ee5\u5f85\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u9664\u4ee5\u4e0a\u516c\u53f8\u4e4b\u5916\uff0c\u56fd\u5185\u62e5\u6709\u4e34\u5e8a\u9636\u6bb5PARP\u6291\u5236\u5242\u7684\u516c\u53f8\u8fd8\u6709\uff1a\u6c5f\u82cf\u8c6a\u68ee\uff08II\u671f\uff09\uff0c\u9752\u5cf0\u836f\u4e1a\u3001\u4eba\u798f\u533b\u836f\u3001\u4e0a\u6d77\u521b\u8bfa\u3001\u82f1\u6d3e\u836f\u4e1a\uff08\u5747\u5904\u4e8eI\u671f\uff09\u3002\u4ece\u901f\u5ea6\u4e0a\uff0c\u4e0e\u5168\u7403\u5df2\u83b7\u6279\u76844\u6b3e\u836f\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u516c\u53f8\u7684\u8fdb\u5ea6\u660e\u663e\u843d\u540e\u4e86\u4e0d\u5c11\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u7bc7\u5e45\u539f\u56e0\uff0c\u8fd9\u4e9b\u54c1\u79cd\u4e0d\u518d\u4e00\u4e00\u8bc4\u8ff0\u3002<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br style=\"background-image: none;box-sizing: border-box;\"><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"display: inline-block;vertical-align: top;background-color: rgb(255, 255, 255);background-image: none;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;padding-right: 5px;color: rgb(104, 23, 255);background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><strong style=\"background-image: none;box-sizing: border-box;\">\u7ed3\u8bed<\/strong><\/p>\n<\/section>\n<section style=\"margin-right: 4px;margin-bottom: 4px;display: inline-block;vertical-align: bottom;width: 5px;border-color: rgb(104, 23, 255);border-right: 1px solid rgb(104, 23, 255);border-left: 1px solid rgb(104, 23, 255);height: 8px;transform-origin: center bottom 0px;-webkit-transform-origin: center bottom 0px;-moz-transform-origin: center bottom 0px;-o-transform-origin: center bottom 0px;transform: skew(-30deg);-webkit-transform: skew(-30deg);-moz-transform: skew(-30deg);-o-transform: skew(-30deg);background-image: none;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"height: 12px;margin-top: -12px;border-top: 1px solid rgb(104, 23, 255);background-image: none;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"display: inline-block;vertical-align: top;background-image: none;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;color: rgb(104, 23, 255);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<p style=\"background-image: none;margin: 0px;padding: 0px;box-sizing: border-box;\"><strong style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u4e00\u3001<br style=\"background-image: none;box-sizing: border-box;\"><\/strong><\/p>\n<\/section>\n<section style=\"width: 0px;border-left: 8px solid rgb(104, 23, 255);border-top: 5px solid transparent;border-bottom: 5px solid transparent;margin-right: 3px;margin-left: 5px;display: inline-block;vertical-align: middle;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><\/section>\n<section style=\"width: 0px;border-left: 8px solid rgb(255, 255, 255);border-top: 4px solid transparent;border-bottom: 4px solid transparent;display: inline-block;vertical-align: middle;margin-right: -9px;transform: rotate(0deg);-webkit-transform: rotate(0deg);-moz-transform: rotate(0deg);-o-transform: rotate(0deg);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><\/section>\n<section style=\"width: 0px;border-left: 10px solid rgb(104, 23, 255);border-top: 6px solid transparent;border-bottom: 6px solid transparent;display: inline-block;vertical-align: middle;background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"background-image: none;box-sizing: border-box;\">\n<section style=\"background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.5;background-image: none;box-sizing: border-box;\">\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><strong style=\"background-image: none;box-sizing: border-box;\"><span style=\"color: rgb(104, 23, 255);background-image: none;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\">\u77ed\u77ed\u4e24\u5e74\u591a\u7684\u65f6\u95f4\uff0c\u5168\u7403PARP\u6291\u5236\u5242\u7684\u7ade\u4e89\u683c\u5c40\u53d1\u751f\u4e86\u975e\u5e38\u5927\u7684\u53d8\u5316\u3002<\/span><\/strong>2016\u5e747\u6708\uff0c\u7b14\u8005\u8ddf\u8e2a\u8be5\u9776\u70b9\u65f6\uff0c\u5168\u7403\u53ea\u67091\u4e2aOlaparib\u83b7\u6279\uff0c\u4e14\u53ea\u7528\u4e8e\u5375\u5de2\u764c\u7684\u56db\u7ebf\u6cbb\u7597\u3002\u800c\u73b0\u5728\uff1a<\/p>\n<p style=\"background-image: none;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;background-color: rgba(1, 0, 0, 0);\"><br 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