{"id":67641,"date":"2018-10-26T01:00:00","date_gmt":"2018-12-07T04:16:46","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/6df12dcdc0\/"},"modified":"2018-12-07T12:16:51","modified_gmt":"2018-12-07T04:16:51","slug":"6df12dcdc0","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/67641\/","title":{"rendered":"\u3010BioWorld Science\u30112018\u5e749\u6708\u836f\u7269\u5feb\u8baf_\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001"},"content":{"rendered":"
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\u4e2d\u6587\u7ffb\u8bd1\uff1a\u963f\u6817\u535a\u58eb<\/span><\/p>\n

Daily Drug News \u5df2\u6b63\u5f0f\u66f4\u540d\u4e3aBioWorld Science<\/span><\/p>\n

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                                2018\u5e749\u670814\u65e5\uff0cOzalin\u6210\u4e3a\u6b27\u6d32\u9996\u4e2a\u83b7\u5f97\u4e0a\u5e02\u8bb8\u53ef\u7684\u513f\u7ae5\u53e3\u670d\u9547\u9759\u5242<\/span><\/p>\n

                                Primex Pharmaceuticals\u516c\u53f8\u7684Ozalin\uff08ADV-6209\uff09\u83b7\u5f97\u4e86\u6b27\u76df\u4e0a\u5e02\u8bb8\u53ef\uff0c\u7528\u4e8e6\u4e2a\u6708\u523017\u5c81\u7684\u513f\u7ae5\u5728\u624b\u672f\u6cbb\u7597\u6216\u8bca\u65ad\u524d\u7684\u9547\u9759\uff0c\u5728\u9ebb\u9189\u524d\u8fdb\u884c\u7528\u836f\u3002Primex Pharmaceuticals\u516c\u53f8\u4eceAdvicenne\u516c\u53f8\u83b7\u5f97\u4e86\u8be5\u836f\u7684\u5168\u7403\u7248\u6743\u3002\uff08\u8be6\u89c1BioWorld Science\uff0c2016\u5e742\u670824\u65e5\uff1bPrimex Pharmaceuticals\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                <\/section>\n<\/section>\n
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                                <\/section>\n<\/section>\n
                                <\/section>\n<\/section>\n
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                                \u751f\u7269\u6807\u5fd7\u7269<\/p>\n<\/section>\n<\/section>\n

                                \n
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                                <\/section>\n<\/section>\n
                                \n
                                <\/section>\n<\/section>\n
                                <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
                                \n
                                \n
                                \n

                                2018\u5e749\u67084\u65e5\uff0cTACI\u86cb\u767d\u6709\u671b\u7528\u4e8e\u5fc3\u529b\u8870\u7aed\u7684\u8bca\u65ad<\/span><\/p>\n

                                \u8de8\u819c\u6d3b\u5316\u5b50\u548cCAML\u4f5c\u7528\u5b50\uff08TACI\uff09\u53c8\u79f0\u4e3aTNFRSF13B\uff0c\u662f\u4e00\u79cdAPRIL\/BAFF\u53d7\u4f53\uff0c\u5728B\u7ec6\u80de\u5b58\u6d3b\u548c\u5206\u5316\u4ee5\u53caT\u7ec6\u80de\u6d3b\u5316\u548c\u708e\u75c7\u8c03\u8282\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u800c\u5b83\u4f5c\u4e3a\u5fc3\u529b\u8870\u7aed\u7684\u4e00\u4e2a\u53ef\u80fd\u7684\u751f\u7269\u6807\u5fd7\u7269\u7684\u4f5c\u7528\u8fd8\u6ca1\u6709\u88ab\u7814\u7a76\u3002\u6709\u7814\u7a76\u4eba\u5458\u91c7\u7528ELISA\u6cd5\u6d4b\u5b9a\u4e86\u4e09\u7ec4\u53d7\u8bd5\u8005\u7684\u53ef\u6eb6\u6027TACI\u6c34\u5e73\uff0c\u5206\u522b\u662f\uff1a\u5065\u5eb7\u4eba\uff08n = 141\uff09\u3001\u5fc3\u5bfc\u7ba1\u672f\u60a3\u8005\uff08n = 16\uff09\u548c\u6025\u6027\u547c\u5438\u56f0\u96be\u5408\u5e76\u6025\u6027\u5931\u4ee3\u507f\u6027\u5fc3\u529b\u8870\u7aed \u60a3\u8005\uff08ADHF, n = 541\uff09\u3002<\/p>\n


                                <\/p>\n

                                \u7814\u7a76\u53d1\u73b0\uff0c\u6b63\u5e38\u4e2a\u4f53\u7684TACI\u6c34\u5e73\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u7565\u6709\u589e\u52a0\u3002\u5fc3\u5bfc\u7ba1\u672f\u60a3\u8005\u7684TACI\u6e05\u9664\u4e3b\u8981\u7531\u5fc3\u810f\u5b8c\u6210\uff0c\u6b21\u8981\u6e05\u9664\u4f4d\u70b9\u662f\u80be\u810f\u3002\u800c\u6b63\u5e38\u4e2a\u4f53\u4e0eADHF\u60a3\u8005\u7684TACI\u6c34\u5e73\u5dee\u5f02\u663e\u8457\uff08P = 0.004\uff09\uff0cADHF\u60a3\u8005TACI\u6c34\u5e73\u504f\u9ad8\uff0c\u4e2d\u4f4d\u6c34\u5e73\u4e3a52 pg\/mL\uff0c\u5176\u4ed6\u4eba\u7fa4\u7684\u4e2d\u4f4d\u503c34 pg\/mL \uff08P = 0.01\uff09\u3002\u5176\u4e2d\uff0c\u7f3a\u8840\u6027\u8d77\u6e90\u7684ADHF\u60a3\u8005\u7684TACI\u6c34\u5e73\u660e\u663e\u9ad8\u4e8e\u5176\u4ed6\u8d77\u6e90\u7684ADHF\u60a3\u8005\uff08P = 0.006\uff09\u3002\u7ecflogistic\u56de\u5f52\u5206\u6790\uff0cTACI\u88ab\u8ba4\u4e3a\u6709\u671b\u4f5c\u4e3a\u4e00\u5e74\u5185\u65b0\u53d1\u5fc3\u529b\u8870\u7aed\u7684\u9884\u6d4b\u56e0\u5b50\u3002\uff08Pemberton, C.J. et al. ESC Congr (Aug 25-29, Munich) 2018, Abst P2791\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u80bf\u7624<\/p>\n<\/section>\n<\/section>\n

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                                <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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                                2018\u5e749\u670828\u65e5\uff0cFDA\u6279\u51c6Vizimpro\u7528\u4e8eEGFR\u7a81\u53d8\u7684\u8f6c\u79fb\u6027NSCLC\u4e00\u7ebf\u6cbb\u7597<\/span><\/p>\n

                                FDA\u8fd1\u65e5\u6279\u51c6\u4e86\u8f89\u745e\u516c\u53f8\u7684\u6fc0\u9176\u6291\u5236\u5242Vizimpro\uff08dacomitinib\uff09\uff0c\u7528\u4e8e\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u5916\u663e\u5b5019\u7f3a\u5931\u6216\u5916\u663e\u5b5021\u53d1\u751fL858R\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u4e00\u7ebf\u6cbb\u7597\u3002Dacomitinib\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5728ARCHER 1050\u4e34\u5e8a\u7814\u7a76\u4e2d\u5f97\u5230\u4e86\u8bc1\u5b9e\uff0c\u8fd9\u662f\u4e00\u9879\u591a\u56fd\u591a\u4e2d\u5fc3\uff0c\u5f00\u653e\u6807\u7b7e\u7684\u968f\u673a\u7814\u7a76\uff0c\u7814\u7a76\u5bf9\u8c61\u662f\u5177\u6709\u4e0a\u8ff0\u7a81\u53d8\u7684\u65e0\u6cd5\u5207\u9664\u7684\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\uff08ClinicalTrials.gov\u7f16\u53f7NCT01774721\uff09\u3002<\/p>\n


                                <\/p>\n

                                \u5728\u4e3b\u8981\u7ec8\u70b9\u65b9\u9762\uff0c\u7ecf\u72ec\u7acb\u653e\u5c04\u5b66\u4e2d\u5fc3\u68c0\u6d4b\uff0c dacomitinib\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\uff08PFS\uff09\u4e0e\u5409\u975e\u66ff\u5c3c\u76f8\u6bd4\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u6539\u5584\u3002Dacomitinib\u7ec4\u7684PFS\u4e2d\u4f4d\u6570\u4e3a14.7\u4e2a\u6708\uff0c\u5409\u975e\u66ff\u5c3c\u7ec4\u4e3a9.2\u4e2a\u6708\u3002Dacomitinib\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08>20%\uff09\u4e3b\u8981\u4e3a\u8179\u6cfb\uff0887%\uff09\u3001\u76ae\u75b9\uff0869%\uff09\u3001\u7532\u4ea2\uff0864%\uff09\u3001\u53e3\u8154\u708e\uff0845%\uff09\u3001\u98df\u6b32\u4e0b\u964d\uff0831%\uff09\u3001\u76ae\u80a4\u5e72\u71e5\uff0830%\uff09\u3001\u4f53\u91cd\u4e0b\u964d\uff0826%\uff09\u3001\u8131\u53d1\uff0823%\uff09\u3001\u54b3\u55fd\uff0821%\uff09\u548c\u7619\u75d2\uff0821%\uff09\u300227%\u7684\u53d7\u8bd5\u8005\u51fa\u73b0\u4e86\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff0c\u6700\u5e38\u89c1\u7684\uff08>= 1%\uff09\u662f\u8179\u6cfb\uff082.2%\uff09\u548c\u95f4\u8d28\u6027\u80ba\u75c5\uff081.3%\uff09\u3002Vizimpro\u5728\u4eca\u5e74\u65e9\u4e9b\u65f6\u5019\u88abFDA\u6388\u4e88\u4e86\u4f18\u5148\u5ba1\u67e5\u8d44\u683c\uff0c\u7528\u4e8e\u5e26\u6709EGFR \u6fc0\u6d3b\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\uff08\u8f89\u745e\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                \n
                                \n
                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
                                \n
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                                \u56fe\u4e3aDacomitinib\u7ed3\u6784<\/span><\/p>\n

                                 <\/p>\n

                                2018\u5e749\u670821\u65e5\uff0cQCA-570\u5728\u4e34\u5e8a\u524d\u767d\u8840\u75c5\u6a21\u578b\u4e2d\u5177\u6709\u6709\u6548\u6027\u548c\u5b89\u5168\u6027<\/span><\/p>\n

                                \u5bc6\u6b47\u6839\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u4e00\u79cd\u65b0\u9896\u7684\u5f3a\u6548\u86cb\u767d\u6c34\u89e3\u5242QCA-570\uff0c\u80fd\u591f\u9776\u5411PROTAC\u5d4c\u5408\u4f53\u7684\u6eb4\u7ed3\u6784\u57df\u548c\u989d\u5916\u672b\u7aef\u7ed3\u6784\u57df\uff08BET\uff09\u3002\u79d1\u5b66\u5bb6\u4ece\u4e00\u7c7b\u65b0\u578b\u7684[1,4]oxazepines\u7c7bBET\u6291\u5236\u5242\u5f00\u59cb\uff0c\u7ecf\u8fc7\u540e\u7eed\u7684\u5408\u6210\u53ca\u5bf9PROTAC \u964d\u89e3\u7684\u6d3b\u6027\u8bc4\u4ef7\u540e\uff0c\u6700\u7ec8\u53d1\u73b0\u4e86QCA-570\u3002\u5728\u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0cQCA-570\u53ef\u4ee5\u6291\u5236\u4eba\u6025\u6027\u767d\u8840\u75c5\u7ec6\u80de\u7cfb\u7684\u7ec6\u80de\u751f\u957f\uff0c\u5728pM\u7ea7\u522b\u7684\u6d53\u5ea6\u4e0b\uff0c\u5316\u5408\u7269\u5bf9MV4;11\u3001MOLM-13\u548cRS4;11\u7ec6\u80de\u7cfb\u7684IC50\u503c\u5206\u522b\u4e3a8.3\uff0c62\u548c32 pM\u3002\u6b64\u5916\uff0c\u57280.5 nM\u6d53\u5ea6\u4e0b\uff0cQCA-570\u80fd\u591f\u8bf1\u5bfcRS4\u7ec6\u80de\u4e2d\u7684BRD2\u3001BRD3\u548cBRD4\u86cb\u767d\u5b8c\u5168\u964d\u89e3\u3002<\/p>\n


                                <\/p>\n

                                \u5728\u4f53\u5185\u8bc4\u4ef7\u4e2d\uff0cQCA-570\u5728RS4;11\u548cMV4;11\u7684\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\u663e\u793a\u4e86\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u4e24\u79cd\u6a21\u578b\u7684\u80bf\u7624\u589e\u6b96\u51fa\u73b0\u4e86\u5b8c\u5168\u548c\u6301\u4e45\u7684\u6291\u5236\u3002\u5e94\u7528QCA-570\u6cbb\u7597\u7684\u52a8\u7269\u4f53\u91cd\u51e0\u4e4e\u6ca1\u6709\u4e0b\u964d\uff0c\u4e5f\u6ca1\u6709\u53d1\u751f\u5176\u4ed6\u6bd2\u6027\u53cd\u5e94\u3002\u7efc\u4e0a\u6240\u8ff0\uff0cQCA-570\u5728\u4f53\u5185\u53ef\u8010\u53d7\u7684\u5242\u91cf\u4e0b\u5177\u6709\u826f\u597d\u7684\u7597\u6548\uff0c\u662f\u76ee\u524d\u5df2\u6709\u62a5\u9053\u7684\u6700\u6709\u6548\u7684BET\u964d\u89e3\u5242\u3002\uff08Qin, C. et al. J Med Chem 2018, 61(15): 6685\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                \n
                                \n
                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u56fe\u4e3aQCA-570\u7ed3\u6784<\/span><\/p>\n

                                 <\/p>\n

                                2018\u5e749\u67085\u65e5\uff0cTesaro\u516c\u53f8\u7528\u4e8e\u6cbb\u7597NSCLC \u7684\u65b0\u836fZejula\u5c06\u5f00\u5c55JASPER\u7814\u7a76\u7684\u7b2c\u4e8c\u9636\u6bb5<\/span><\/p>\n

                                Tesaro\u516c\u53f8\u542f\u52a8\u4e86JASPER\u7814\u7a76\u7684\u7b2c\u4e8c\u9636\u6bb5\uff0c\u65e8\u5728\u8bc4\u4f30Zejula\uff08niraparib\uff09\u4e0ePD-1\u6297\u4f53\u8054\u5408\u5e94\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u4e34\u5e8a\u7597\u6548\uff08ClinicalTrials.gov\u7f16\u53f7NCT03308942\uff09\u3002\u63a8\u8fdb\u8be5\u8bd5\u9a8c\u7684\u51b3\u5b9a\u662f\u57fa\u4e8e\u5728\u521d\u671f\u7814\u7a76\u4e2d\uff0c\u8be5\u836f\u8fbe\u5230\u4e86\u65e2\u5b9a\u7684\u6cbb\u7597\u6548\u679c\uff0c\u5728\u5176\u6cbb\u7597\u768416\u4f8b\u8868\u8fbePD-L1\u7684NSCLC\u60a3\u8005\u4e2d\uff0c14\u4f8b\u8fdb\u884c\u4e86\u6548\u679c\u8bc4\u4f30\u3002\u5176\u4e2d\u67099\u4f8b\u8fbe\u5230\u4e86RECIST\u6807\u51c6\u7684\u5ba2\u89c2\u7f13\u89e3\uff0c\u6240\u670914\u4f8b\u60a3\u8005\u90fd\u51fa\u73b0\u4e86\u80bf\u7624\u7f29\u5c0f\u3002\u5728\u8be5\u8bd5\u9a8c\u7684\u7b2c\u4e8c\u9636\u6bb5\uff0c\u53e6\u5916\u62db\u52df\u768436\u540d\u60a3\u8005\u5c06\u63a5\u53d7Zejula\u8054\u5408TSR-042 \uff08dostarlimab\uff09\u7684\u6cbb\u7597\uff0cTSR-042\u662f\u8be5\u516c\u53f8\u7684\u4e00\u79cd\u6297PD-1\u6297\u4f53\u3002\u5728\u80ba\u764c\u4e2d\uff0cTSR-042\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u6b63\u5728\u8fdb\u884c\u540d\u4e3aGARNET\u7684\u7814\u7a76\uff0c\u7528\u4e8e\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u4e14\u521d\u6b21\u4f7f\u7528PD-(L)1\u7597\u6cd5\u7684\u60a3\u8005\uff1b\u5e76\u4e0eTSR-022\uff08Tesaro\u7684\u6297TIM-3\u6297\u4f53\uff09\u8054\u5408\uff0c\u5728AMBER\u7814\u7a76\u4e2d\u88ab\u7528\u4e8e\u6cbb\u7597\u6297PD-(L)1\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u665a\u671fNSCLC\u60a3\u8005\u3002\uff08Tesaro\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                \n
                                \n
                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u56fe\u4e3aNiraparib\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u80bf\u7624\u514d\u75ab\u7597\u6cd5<\/p>\n<\/section>\n<\/section>\n

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                                <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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                                \n

                                2018\u5e749\u670818\u65e5\uff0cFDA\u89e3\u9664\u5bf9XMT-1522\u7684\u90e8\u5206\u4e34\u5e8a\u6682\u505c<\/span><\/p>\n

                                Mersana Therapeutics\u516c\u53f8\u5ba3\u5e03\uff0cFDA\u5df2\u89e3\u9664\u4e86\u5bf9XMT-1522\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u90e8\u5206\u4e34\u5e8a\u6682\u505c\uff08partial clinical hold\uff09\uff0c\u8fd9\u662f\u4e00\u4e2a\u9488\u5bf9HER2\u8868\u8fbe\u80bf\u7624\u7684dolaflexin\u2013\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff08ClinicalTrials.gov\u7f16\u53f7NCT02952729\uff1b\u8be6\u89c12018\u5e747\u670820\u65e5\u7684BioWorld Science\uff09\u3002Mersana\u4e0eFDA\u5c31\u8be5\u7814\u7a76\u7684\u53d8\u5316\u8fbe\u6210\u4e00\u81f4\uff0c\u5305\u62ec\u589e\u52a0\u76d1\u6d4b\u53ca\u6392\u9664\u665a\u671f\u809d\u635f\u5bb3\u60a3\u8005\u3002\u5c3d\u7ba1Mersana\u7684\u53e6\u4e00\u4e2a\u9776\u5411NaPi2b\u6297\u4f53\u7684dolaflexin ADC\uff08XMT-1536\uff09\u5e76\u4e0d\u5728\u6b64\u6b21\u4e34\u5e8a\u6682\u505c\u4e2d\uff0c\u4f46\u8be5\u516c\u53f8\u4e5f\u540c\u65f6\u51b3\u5b9a\u5bf9XMT-1536\u7684\u4e34\u5e8a\u534f\u8bae\u8fdb\u884c\u7c7b\u4f3c\u7684\u4fee\u6539\uff08ClinicalTrials.gov\u7f16\u53f7NCT03319628\uff09\u3002\u6b64\u5916\uff0c\u8fd9\u4e24\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed9\u836f\u65b9\u6848\u4e5f\u5c06\u91cd\u65b0\u8bc4\u4f30\u3002XMT-1522\u8bd5\u9a8c\u5c06\u4ee5\u6bcf4\u5468\u4e00\u6b21\u7684\u5242\u91cf\u65b9\u6848\u5f00\u59cb\uff0c\u8be5\u65b9\u6848\u5df2\u7ecf\u5728XMT-1536\u4e34\u5e8a\u8bd5\u9a8c\u7684\u524d\u671f\u63a2\u7d22\u5e76\u5b9e\u65bd\uff0c\u4ee5\u4fbf\u80fd\u591f\u6bd4\u8f83\u76f8\u5173\u5242\u91cf\u5bf9\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\u3002\u8be5\u516c\u53f8\u8fd8\u53ef\u80fd\u8bc4\u4f30\u989d\u5916\u7684\u6cbb\u7597\u65b9\u6848\u3002XMT-1536\u7684\u4e34\u5e8a\u6570\u636e\u9884\u8ba1\u5c06\u5728\u660e\u5e74\u4e0a\u534a\u5e74\u53d1\u5e03\u3002\uff08Mersana Therapeutics\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n

                                 <\/p>\n

                                2018\u5e749\u670827\u65e5\uff0cVaccibody \u516c\u53f8\u53d1\u8868VB10.16\u514d\u75ab\u7597\u6cd5\u7684I\/IIa\u671f\u7814\u7a76\u76846\u4e2a\u6708\u4e2d\u671f\u9633\u6027\u7ed3\u679c<\/span><\/p>\n

                                Vaccibody\u516c\u53f8\u5ba3\u5e03\u4e86\u540d\u4e3aVB C-01\u7684\u4e34\u5e8a\u7814\u7a76IIa\u671f\u90e8\u5206\u76846\u4e2a\u6708\u4e2d\u671f\u9633\u6027\u7ed3\u679c\uff08ClinicalTrials.gov\u7f16\u53f7NCT02529930\uff09\u3002\u8be5\u5f00\u653e\u6807\u7b7e\u7684\u591a\u4e2d\u5fc3\u7684I\/IIa\u671f\u8bd5\u9a8c\u662fVB10.16\u514d\u75ab\u7597\u6cd5\u7684\u9996\u6b21\u4eba\u4f53\u5242\u91cf\u8bd5\u9a8c\uff0c\u7528\u4e8e\u6cbb\u7597\u7531\u4eba\u4e73\u5934\u7624\u75c5\u6bd216\uff08HPV16\uff09\u5f15\u8d77\u7684\u9ad8\u7ea7\u522b\u5bab\u9888\u4e0a\u76ae\u5185\u7624\u53d8\uff08CIN2-3\u7ea7\uff09\u3002\u5171\u62db\u52df18\u4f8bCIN2-3\u7ea7\u7684\u60a3\u8005\u3002\u5176\u4e2d1\u4f8b\u60a3\u8005\u9000\u51fa\u4e86\u6cbb\u7597\uff0c\u5176\u4f59\u60a3\u8005\u5728\u7b2c0\u5468\u3001\u7b2c3\u5468\u3001\u7b2c6\u5468\u548c\u7b2c16\u5468\u5206\u522b\u63a5\u53d7\u4e864\u6b21\u5242\u91cf\u4e3a3\u6beb\u514b\u7684VB10.16\u7684\u6cbb\u7597\u3002<\/p>\n


                                <\/p>\n

                                IIa\u671f\u8bd5\u9a8c\u7684\u4e3b\u8981\u76ee\u6807\u662f\u8bc4\u4f30VB10.16\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u6b21\u8981\u76ee\u6807\u662f\u8bc4\u4f30\u5916\u5468\u8840\u4e2dT\u7ec6\u80de\u4ecb\u5bfc\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u5e76\u901a\u8fc7CIN\u8bc4\u7ea7\u548cHPV\u6e05\u9664\u6c34\u5e73\u6765\u8bc4\u4f30\u65e9\u671f\u7597\u6548\u3002\u8be5\u75ab\u82d7\u901a\u8fc7\u65e0\u75db\u6ce8\u5c04\u7cfb\u7edfPharmaJet Stratis\u6ce8\u5c04\u3002\u4e2d\u671f\u7ed3\u679c\u8868\u660e\uff0c\u56db\u5242VB10.16\u5728\u7814\u7a76\u7684I\u671f\u548cIIa\u671f\u8010\u53d7\u6027\u826f\u597d\u3002\u65e0\u9884\u6599\u4e4b\u5916\u7684\u4e0d\u826f\u4e8b\u4ef6\u6216\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u62a5\u544a\uff0c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u662f\u77ed\u6682\u7684\u8f7b\u5fae\u5230\u4e2d\u7b49\u7684\u6ce8\u5c04\u90e8\u4f4d\u53cd\u5e94\u3002\u5916\u5468\u8840\u7684\u514d\u75ab\u5b66\u5206\u6790\u663e\u793a\uff0c17\u4f8b\u60a3\u8005\u5747\u6709\u5f3a\u70c8\u7684HPV16\u7279\u5f02\u6027T\u7ec6\u80de\u514d\u75ab\u5e94\u7b54\uff0c\u5176\u4e2d16\u4f8b\u60a3\u8005\u5bf9\u75ab\u82d7\u4e2d\u4f7f\u7528\u7684\u4e24\u79cd\u6297\u539f\uff08HPV16\u86cb\u767dE6\u548cE7\uff09\u5747\u6709\u5e94\u7b54\u30021\u540d\u60a3\u8005\u7531\u4e8e\u57fa\u7ebf\u53cd\u5e94\u5f3a\u70c8\uff0c\u56e0\u6b64\u6ca1\u6709\u88ab\u75ab\u82d7\u8fdb\u4e00\u6b65\u8bf1\u5bfc\u3002<\/p>\n


                                <\/p>\n

                                \u8fd9\u4e9b\u7ed3\u679c\u4e3aVaccibody\u7684DNA\u75ab\u82d7\u6280\u672f\u63d0\u4f9b\u4e86\u6982\u5ff5\u9a8c\u8bc1\uff0c\u8bc1\u660e\u4e86\u5176\u80fd\u591f\u4ea7\u751f\u5feb\u901f\u3001\u5f3a\u70c8\u548c\u6301\u4e45\u7684\u514d\u75ab\u53cd\u5e94\u30021\u4f8b\u60a3\u8005\u57284\u4e2a\u6708\u65f6\u8fdb\u884c\u4e86\u5bab\u9888\u9525\u72b6\u5207\u9664\uff0c\u56e0\u6b64\u57286\u4e2a\u6708\u65f6\u65e0\u6cd5\u8fdb\u884c\u8bc4\u4f30\u3002\u5176\u4f5916\u4f8b\u60a3\u8005\u4e2d\u670915\u4f8b\u57286\u4e2a\u6708\u65f6\u51fa\u73b013\u4f8b\u90e8\u5206\u5e94\u7b54\u548c2\u4f8b\u5b8c\u5168\u5e94\u7b54\uff0c\u53e61\u4f8b\u75c5\u60c5\u7a33\u5b9a\u300214\u4f8b\u60a3\u8005\u57286\u4e2a\u6708\u7684\u9634\u9053\u955c\u68c0\u67e5\u4e2d\u53d1\u73b0\u75c5\u53d8\u51cf\u5c0f\uff0c\u4e2d\u4f4d\u51cf\u5c0f50%\u3002\u5176\u4e2d8\u4f8b\u60a3\u8005\u5728\u7ec4\u7ec7\u75c5\u7406\u5b66\u4e0a\u9000\u56de\u5230CIN 1\u7ea7\u6216\u65e0\u75be\u75c5\u72b6\u6001\uff0c8\u4f8b\u60a3\u8005\u57286\u4e2a\u6708\u4ee5\u5185\u6ca1\u6709\u9000\u5230CIN 1\u7ea7\u30026\u4f8b\u60a3\u8005\u663e\u793a\u4e86PD-L1\u7684\u4e0a\u8c03\uff0c\u8fd9\u53ef\u80fd\u5ef6\u8fdf\u6216\u6291\u5236\u4e86\u53d7\u611f\u67d3\u7ec6\u80de\u7684\u6e05\u9664\u3002\u8fd9\u4e9b\u60a3\u8005\u4e2d\u67093\u4eba\u957f\u671f\u4e0e\u5176\u4ed6\u9ad8\u5371HPV\u6bd2\u682a\u5408\u5e76\u611f\u67d3\uff0c\u5176\u4e2d1\u4eba\u5df2\u6e05\u9664HPV16\u3002\u57284\u4e2a\u6708\u65f6\u8fdb\u884c\u7b2c4\u6b21\u63a5\u79cd\u75ab\u82d7\u53ef\u663e\u8457\u63d0\u9ad8T\u7ec6\u80de\u53cd\u5e94\uff0c\u57286\u4e2a\u6708\u65f6\u53cd\u5e94\u6700\u5f3a\u3002\u8be5\u7814\u7a76\u5c06\u5728\u9996\u6b21\u63a5\u79cd\u75ab\u82d7\u540e\u768412\u4e2a\u6708\u540e\u76d1\u6d4b\u75c5\u7076\u5927\u5c0f\u548cCIN\u7ea7\u522b\u7684\u6d88\u9000\uff0c\u8fd9\u4e9b\u6570\u636e\u5c06\u4e8e2019\u5e74\u7b2c\u4e00\u5b63\u5ea6\u516c\u5e03\u3002\uff08Vaccibody \u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n

                                 <\/p>\n

                                2018\u5e749\u670814\u65e5\uff0cNatera\u4e0eBMS\u8fbe\u6210\u534f\u8bae\u5c06\u5728Opdivo\u8bd5\u9a8c\u4e2d\u4f7f\u7528Signatera ctDNA\u68c0\u6d4b\u6280\u672f<\/span><\/p>\n

                                Natera\u516c\u53f8\u4e0eBMS\u516c\u53f8\u8fbe\u6210\u534f\u8bae\uff0c\u5c06\u5728\u4e00\u9879\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u4f7f\u7528Natera\u7684Signatera\u5b9a\u5236\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u68c0\u6d4b\u6280\u672f\uff0c\u6765\u7b5b\u9009\u5728\u624b\u672f\u5207\u9664\u540e\u5177\u6709\u6700\u5c0f\u6b8b\u7559\u75be\u75c5\uff08MRD\uff09\u7684\u60a3\u8005\uff0c\u4ee5\u63a5\u53d7\u6709\u6216\u65e0Opdivo\uff08nivolumab\uff09\u7684\u8f85\u52a9\u6cbb\u7597\u3002\u5728Natera\u516c\u53f8\u6839\u636e\u4e34\u5e8a\u5b9e\u9a8c\u5ba4\u6539\u8fdb\u4fee\u6b63\u6848\uff08CLIA\uff09\u5b8c\u6210\u5176ctDNA\u68c0\u6d4b\u65b9\u6cd5\u9a8c\u8bc1\u7684\u524d\u63d0\u4e0b\uff0c\u7b2c\u4e00\u4e2a\u75c5\u4eba\u9884\u8ba1\u5c06\u5728\u660e\u5e74\u5165\u7ec4\u3002<\/p>\n


                                <\/p>\n

                                \u672c\u7814\u7a76\u662f\u7b2c\u4e00\u6b21\u4f7f\u7528Signatera ctDNA\u68c0\u6d4b\u6280\u672f\u8f85\u52a9NSCLC\u6cbb\u7597\u7684\u524d\u77bb\u6027\u4e34\u5e8a\u8bd5\u9a8c\u3002\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u8be5\u68c0\u6d4b\u6280\u672f\u80fd\u591f\u68c0\u6d4b\u6b8b\u7559\u75c5\u7076\uff0c\u8bc4\u4ef7\u6cbb\u7597\u54cd\u5e94\uff0c\u5e76\u80fd\u6bd4\u65e9\u671fNSCLC\u7684\u6cbb\u7597\u6807\u51c6\u63d0\u524d11\u4e2a\u6708\u53d1\u73b0\u80bf\u7624\u7684\u590d\u53d1\uff0c\u5177\u670993%\u7684\u654f\u611f\u6027\u548c\u96f6\u5047\u9633\u6027\u3002\u57fa\u4e8e\u5148\u524d\u62ab\u9732\u7684\u7814\u7a76\u8005\u53d1\u8d77\u7684\u5305\u62ec\u4e73\u817a\u764c\u3001\u80ba\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u548c\u8180\u80f1\u764c\u5728\u5185\u7684\u7814\u7a76\u7ed3\u679c\uff0cNatera\u5df2\u4e0e\u591a\u5bb6\u516c\u53f8\u7b7e\u7f72\u5408\u4f5c\u534f\u8bae\uff0c\u4e3a\u8be5\u6280\u672f\u5e94\u7528\u4e8e\u591a\u79cd\u80bf\u7624\u7684\u4e34\u5e8a\u9a8c\u8bc1\u5960\u5b9a\u4e86\u57fa\u7840\u3002Signatera\u65b9\u6cd5\u4e0d\u540c\u4e8e\u76ee\u524d\u53ef\u7528\u7684\u6db2\u4f53\u6d3b\u68c0\u65b9\u6cd5\uff0c\u5b83\u80fd\u591f\u4e3a\u6bcf\u4f4d\u60a3\u8005\u63d0\u4f9b\u91cf\u8eab\u5b9a\u5236\u7684\u8840\u6db2\u68c0\u6d4b\uff0c\u4ee5\u5339\u914d\u4e2a\u4f53\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u7a81\u53d8\uff0c\u6700\u5927\u9650\u5ea6\u5730\u63d0\u9ad8\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\u3002\u4eca\u5e74\u53d1\u8868\u7684\u7814\u7a76\u663e\u793a\uff0c\u8be5\u6280\u672f\u5728\u8180\u80f1\u764c\u548c\u7ed3\u76f4\u80a0\u764c\u7684\u7814\u7a76\u53d6\u5f97\u4e86\u6210\u529f\uff0cctDNA\u7684\u4e2d\u4f4d\u68c0\u6d4b\u65f6\u95f4\u5206\u522b\u4e3a4.3\u4e2a\u6708\u548c7.9\u4e2a\u6708\uff0c\u9886\u5148\u4e8e\u4e34\u5e8a\u590d\u53d1\u68c0\u6d4b\u3002\uff08Natera\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u5fc3\u8840\u7ba1\u75be\u75c5<\/p>\n<\/section>\n<\/section>\n

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                                2018\u5e749\u670826\u65e5\uff0cEZH2\u53ef\u4f5c\u7528\u80ba\u52a8\u8109\u9ad8\u538b\u7684\u751f\u7269\u6807\u5fd7\u7269<\/span><\/p>\n

                                \u6765\u81eaLaval\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u8bc4\u4f30\u4e86\u7ec4\u86cb\u767d\u8d56\u6c28\u9178N-\u7532\u57fa\u8f6c\u79fb\u9176EZH2\u5728\u80ba\u52a8\u8109\u9ad8\u538b\uff08PAH\uff09\u4e2d\u7684\u4f5c\u7528\u3002\u4ecePAH\u60a3\u8005\u8eab\u4e0a\u5206\u79bb\u7684\u80ba\u7ec4\u7ec7\u3001\u80ba\u52a8\u8109\u5207\u7247\u548c\u80ba\u52a8\u8109\u5e73\u6ed1\u808c\u7ec6\u80de\uff08PASMCs\uff09\u4e2d\u7684EZH2\u8868\u8fbe\u91cf\u5747\u6bd4\u5bf9\u7167\u7ec4\u589e\u52a0\uff0c\u5728PAH\u5927\u9f20\u6a21\u578b\u7684PASMC\u4e2d\u4e5f\u6709\u76f8\u4f3c\u7684\u8d8b\u52bf\u3002EZH2\u7684\u6291\u5236\u80fd\u591f\u963b\u65adPAH-PASMCs\u7ec6\u80de\u589e\u6b96\u5e76\u8bf1\u5bfc\u51cb\u4ea1\uff0c\u800c\u6291\u5236PAH-PASMCs\u4e2d\u8fc7\u8868\u8fbe\u7684BRD4\u80fd\u591f\u964d\u4f4eEZH2\u7684\u8868\u8fbe\u3002\u5bf9PAH-PASMCs\u4e2dEZH2\u6572\u9664\u7684\u86cb\u767d\u7ec4\u5b66\u5206\u6790\u8868\u660e\uff0cEZH2\u5728PAH-PASMCs\u7684\u7ebf\u7c92\u4f53\u529f\u80fd\u5f02\u5e38\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u3002\u6700\u540e\uff0c\u4e00\u9879\u53f3\u5fc3\u5ba4\u91cd\u6784\u7684\u4f53\u5185\u5b9e\u9a8c\u8868\u660e\uff0c\u53f3\u5fc3\u5ba4\u7684EZH2\u4e0a\u8c03\u6291\u5236\u4e86\u9002\u5e94\u6027\u53f3\u5fc3\u5ba4\u80a5\u5927\u75c7\u72b6\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u8fd9\u4e9b\u53d1\u73b0\u63d0\u793aEZH2\u5728\u80ba\u52a8\u8109\u9ad8\u538b\u4e2d\u8fc7\u8868\u8fbe\uff0c\u4e14\u4e0ePASMCs\u7684\u4fc3\u589e\u6b96\u548c\u6297\u51cb\u4ea1\u8868\u578b\u5173\u7cfb\u5bc6\u5207\u3002\uff08Habbout, K. et al. 28th Annu Congr Eur Respir Soc (ERS) (Sept 15-19, Paris) 2018, Abst PA3925\uff09\u3002<\/p>\n

                                 <\/p>\n

                                2018\u5e749\u67084\u65e5\uff0cMedImmune\u516c\u53f8\u53d1\u8868\u65b0\u7684\u6297\u5fc3\u529b\u8870\u7aed\u878d\u5408\u86cb\u767d\u4e13\u5229<\/span><\/p>\n

                                MedImmune\u53d1\u73b0\u4e86\u65b0\u578b\u7684\u677e\u5f1b\u7d20\uff08relaxin\uff09\u878d\u5408\u591a\u80bd\uff0c\u5b83\u5305\u542b\u4e00\u4e2a\u4e0erelaxin 2\uff08RLX2\uff09A\u94fe\u76f8\u8fde\u7684\u514d\u75ab\u7403\u86cb\u767dFc\u533a\u57df\uff0c\u518d\u901a\u8fc7\u94fe\u63a5\u5b50\u878d\u5408\u5230relaxin B\u94fe\u4e0a\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u5fc3\u529b\u8870\u7aed\u3002\u4ee3\u8868\u4ea7\u54c1Fc_hRLX2_15-15AA\u662f\u4e00\u79cdFc\u878d\u5408\u86cb\u767d\uff0c\u7531\u4eba\u7c7blgG1\u7684Fc\u533a\u57df\u300115\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\u7684\u8fde\u63a5\u5b50(GGGGS)3\u3001relaxin 2A\u94fe\u3001\u7b2c\u4e8c\u4e2a15\u4e2a\u6c28\u57fa\u9178\u8fde\u63a5\u5b50(GGGGS)3\u548crelaxin 2B\u94fe\u878d\u5408\u800c\u6210\uff0c\u5728CHO\u7ec6\u80de\u4e2d\u8868\u8fbe\u3002Fc_hRLX2_15-15AA\u80fd\u591f\u523a\u6fc0cAMP\u7684\u4ea7\u751f\uff0c\u5728\u7ec6\u80decAMP\u68c0\u6d4b\u4e2d\u7684EC50\u503c\u4e3a9.84 x 10(-10) M\u3002\u5b83\u8fd8\u80fd\u591f\u663e\u8457\u7684\u8bf1\u5bfc\u4eba\u5355\u6838\u7ec6\u80de\uff08THP-1\uff09\u7684\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u8868\u8fbe\u3002Fc_hRLX2_15-15AA\u53ef\u4ee5\u5206\u522b\u6fc0\u6d3b\u4eba\u6216\u5c0f\u9f20\u7684RXFP1\u548c\u4eba\u7684RXFP2\u53d7\u4f53, EC50\u503c\u5206\u522b\u4e3a1 .84 x 10(-9)\u30011 .51 x 10(-9)\u548c\u22659.32 x 10(-6) M\uff0c\u4ece\u800c\u523a\u6fc0CHO\u7ec6\u80de\u4ea7\u751fcAMP\u3002\u836f\u4ee3\u52a8\u529b\u5b66\u5206\u6790\u663e\u793a\uff0cFc_hRLX2_4-15AA\u5728\u5927\u9f20\u4f53\u5185\u9759\u8109\u6ce8\u5c04\u548c\u76ae\u4e0b\u6ce8\u5c04\u7684t1\/2\u5206\u522b\u4e3a3.59 h\u548c3.75 h\u3002\u5728\u53e6\u4e00\u9879\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u4e2d\uff0cFc_hRLX2_4-15AA\uff086 mg\/kg\uff09\u5728\u5c0f\u9f20\u4f53\u5185\u7684\u76ae\u4e0b\u6ce8\u5c04\u534a\u8870\u671f\u6bd4\u9759\u8109\u6ce8\u5c04\u534a\u8870\u671f\u5ef6\u957f\u4e86\u7ea626.5%\u3002\u8be5\u878d\u5408\u86cb\u767d\u5728\u4eba\u548c\u5c0f\u9f20\u4e4b\u95f4\u8868\u73b0\u51fa\u4ea4\u53c9\u53cd\u5e94\u6027\uff0c\u4e0eFc\u7684\u878d\u5408\u4e0d\u5f71\u54cd\u6b64\u4ea4\u53c9\u53cd\u5e94\u6027\u3002C57BL\/6J\u5c0f\u9f20\u7528\u5f02\u4e19\u80be\u4e0a\u817a\u7d20\uff0815mg\/kg\/\u5929\uff09\u5904\u7406\u540e\uff0c\u5fc3\u808c\u80a5\u539a\u548c\u7ea4\u7ef4\u5316\u660e\u663e\u589e\u52a0\uff0c\u540c\u65f6HW\/TL\u548c\u80f6\u539f\u86cb\u767d\u542b\u91cf\u589e\u52a0\u3002\u800c\u7528Fc_hRLX2_15-15AA\uff0830 mg\/kg, 1\u5468\uff09\u4e0e\u5f02\u4e19\u80be\u4e0a\u817a\u7d20\uff0815mg\/kg\/\u5929\uff09\u540c\u65f6\u5904\u7406\u5c0f\u9f20\uff0c\u53ef\u663e\u8457\u964d\u4f4e\u4e0a\u8ff0\u6548\u5e94\u3002\uff08\u8be6\u89c1\u4e13\u5229WO 2018138170\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u836f\u7269\u8bbe\u8ba1\u4e0e\u836f\u7269\u91ca\u653e\u6280\u672f<\/p>\n<\/section>\n<\/section>\n

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                                2018\u5e749\u670813\u65e5\uff0c\u7eb3\u7c73\u8f7d\u4f53\u8868\u9762\u6297\u4f53\u9884\u5438\u9644\u80fd\u591f\u514b\u670d\u751f\u7269\u5206\u5b50\u7535\u6655<\/span><\/p>\n

                                \u7eb3\u7c73\u8f7d\u4f53\u901a\u5e38\u53ef\u4ee5\u901a\u8fc7\u5316\u5b66\u5171\u4ef7\u4e0e\u9776\u5411\u6027\u7684\u6297\u4f53\u6216\u914d\u4f53\u8fde\u63a5\uff0c\u7528\u4e8e\u5c06\u5230\u9776\u5668\u5b98\u6216\u7ec6\u80de\u3002\u7136\u800c\uff0c\u5f53\u7eb3\u7c73\u8f7d\u4f53\u66b4\u9732\u5728\u8840\u6d46\u7b49\u751f\u7269\u6db2\u4f53\u4e2d\u65f6\uff0c\u5e38\u4f1a\u7531\u4e8e\u5438\u9644\u86cb\u767d\u8d28\u53d1\u751f\u7535\u6655\u5f62\u6210\u201c\u86cb\u767d\u51a0\u201d\uff0c\u963b\u788d\u7eb3\u7c73\u9897\u7c92\u7684\u9776\u5411\u529f\u80fd\u3002\u5fb7\u56fdGutenberg-University Mainz\u7684\u7814\u7a76\u4eba\u5458\u6700\u8fd1\u7684\u7814\u7a76\u8bc1\u5b9e\uff0c\u82e5\u9884\u5148\u5c06\u7279\u5b9a\u6297\u4f53\u6216\u914d\u4f53\u5438\u9644\u5230\u7eb3\u7c73\u8f7d\u4f53\u8868\u9762\uff0c\u4fbf\u80fd\u591f\u514b\u670d\u86cb\u767d\u51a0\u7684\u5f62\u6210\uff0c\u5b9e\u73b0\u8f7d\u4f53\u7684\u9776\u5411\u529f\u80fd\u3002<\/p>\n


                                <\/p>\n

                                \u6570\u636e\u8868\u660e\uff0c\u5728pH=6.1\u65f6\u5bf9\u8868\u9762\u5e26\u6709\u7fa7\u57fa\u57fa\u56e2\u7684\u805a\u5408\u7269\u7eb3\u7c73\u7c92\u5b50\u8fdb\u884c\u6297\u4f53\u7684\u7269\u7406\u5438\u9644\uff0c\u9884\u5438\u9644\u7684\u6297\u4f53\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u4fdd\u6301\u4e86\u529f\u80fd\uff0c\u6ca1\u6709\u88ab\u5b8c\u5168\u4ea4\u6362\u6216\u88ab\u7535\u6655\u8986\u76d6\uff0c\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5076\u8054\u6297\u4f53\u53d7\u8fd9\u79cd\u4fdd\u62a4\u7684\u5f71\u54cd\u66f4\u5927\u3002\u6297\u4f53\u5438\u9644\u662f\u4e00\u4e2a\u4f9d\u8d56\u4e8epH\u7684\u8fc7\u7a0b\u3002\u6b64\u5916\uff0c\u4e0e\u5bf9\u7167\u9897\u7c92\u76f8\u6bd4\uff0c\u6297\u4f53\u5438\u9644\u80fd\u6539\u5584\u9776\u7ec6\u80de\u5728\u6240\u6709\u6d53\u5ea6\u4e0b\u7684\u5438\u6536\u3002\u8be5\u7b56\u7565\u80fd\u591f\u6269\u5c55\u5230\u8868\u9762\u4fee\u9970\u7684\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\uff0c\u751a\u81f3\u6269\u5c55\u5230\u7531\u7f9f\u4e59\u57fa\u6dc0\u7c89\u5236\u6210\u7684\u53ef\u751f\u7269\u964d\u89e3\u7684\u7eb3\u7c73\u8f7d\u4f53\u4e0a\uff0c\u5e76\u7528\u4e8e\u9012\u9001\u5c0f\u7684\u751f\u7269\u6d3b\u6027\u86cb\u767d\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u6297\u4f53\u9884\u5438\u9644\u662f\u4e00\u79cd\u591a\u529f\u80fd\u3001\u9ad8\u6548\u548c\u5feb\u901f\u7684\u5c06\u9776\u5411\u7269\u9644\u7740\u5728\u7eb3\u7c73\u8f7d\u4f53\u8868\u9762\u65b9\u6cd5\u3002\u590d\u6742\u86cb\u767d\u73af\u5883\u548c\u4e0d\u540c\u7684\u7f13\u51b2\u6761\u4ef6\u5bf9\u8be5\u65b9\u6cd5\u7684\u5f71\u54cd\u5c06\u4f1a\u8fdb\u4e00\u6b65\u7814\u7a76\u3002\uff08Tonigold, M. et al. Nat Nanotech 2018, Advanced publication\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u5185\u5206\u6ccc\u7cfb\u7edf\u75be\u75c5<\/p>\n<\/section>\n<\/section>\n

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                                2018\u5e749\u670818\u65e5\uff0cCRISPR Therapeutics\u548cViaCyte\u5c31\u57fa\u56e0\u7f16\u8f91\u540c\u79cd\u5f02\u4f53\u7528\u4e8e\u6cbb\u7597\u7cd6\u5c3f\u75c5\u8fbe\u6210\u5408\u4f5c<\/span>
                                <\/p>\n

                                \u745e\u58ebCRISPR Therapeutics\u548c\u7f8e\u56fdViaCyte\u5ba3\u5e03\u5c31\u5171\u540c\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u7cd6\u5c3f\u75c5\u7684\u57fa\u56e0\u7f16\u8f91\u540c\u79cd\u5f02\u4f53\u7597\u6cd5\u8fbe\u6210\u534f\u8bae\u3002ViaCyte\u516c\u53f8\u7684\u4e3b\u5bfc\u4ea7\u54c1PEC-Direct\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u8bc4\u4f30\uff0c\u5b83\u4f7f\u7528\u4e86\u4e00\u79cd\u975e\u514d\u75ab\u4fdd\u62a4\u7684\u4f20\u9012\u88c5\u7f6e\uff0c\u5185\u7f6e\u4e8e\u76ae\u4e0b\u5e76\u76f4\u63a5\u901a\u8fc7\u8840\u7ba1\u8fdb\u884c\u7ec6\u80de\u6cbb\u7597\u3002\u8be5\u6280\u672f\u76ee\u524d\u6b63\u5728\u88ab\u7528\u4e8e\u5f00\u53d1\u6cbb\u75971\u578b\u7cd6\u5c3f\u75c5\u6025\u6027\u5e76\u53d1\u75c7\u7684\u7597\u6cd5\u3002CRISPR\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u63d0\u4f9b\u4e86\u4e00\u79cd\u4fdd\u62a4\u79fb\u690d\u7ec6\u80de\u514d\u53d7\u60a3\u8005\u514d\u75ab\u7cfb\u7edf\u4f24\u5bb3\u65b9\u6cd5\uff0c\u5373\u5bf9\u7528\u4e8e\u4ea7\u751f\u80f0\u810f\u7ec6\u80de\u7684\u7684\u514d\u75ab\u8c03\u8282\u57fa\u56e0\u8fdb\u884c\u4f53\u5916\u7f16\u8f91\u3002\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u4e24\u5bb6\u516c\u53f8\u5c06\u5171\u540c\u5bfb\u6c42\u5f00\u53d1\u4e00\u79cd\u514d\u75ab\u9003\u9038\u7684\u7cfb\uff0c\u4f5c\u4e3a\u5f00\u53d1\u5f02\u4f53\u884d\u751f\u4ea7\u54c1\u7684\u7b2c\u4e00\u6b65\u3002\u5728\u5b8c\u6210\u4e0a\u8ff0\u7814\u7a76\u5e76\u786e\u5b9a\u5019\u9009\u4ea7\u54c1\u540e\uff0c\u5c06\u5171\u540c\u627f\u62c5\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u7684\u8d23\u4efb\u3002ViaCyte\u5c06\u83b7\u5f97\u7531CRISPR\u63d0\u4f9b\u7684\u73b0\u91d1\u6216\u80a1\u7968\u51711500\u4e07\u7f8e\u5143\u3002\u5728\u67d0\u4e9b\u7279\u5b9a\u60c5\u51b5\u4e0b\uff0cViaCyte\u516c\u53f8\u8fd8\u53ef\u83b7\u5f97\u989d\u5916\u76841000\u4e07\u7f8e\u5143\u7684\u53ef\u8f6c\u6362\u672c\u7968\u3002\uff08CRISPR Therapeutics\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e749\u67086\u65e5\uff0cEnanta Pharmaceuticals\u516c\u53f8\u53d1\u8868\u65b0\u578b\u7684NR1H4\u6fc0\u52a8\u5242\u4e13\u5229<\/span><\/p>\n

                                Enanta Pharmaceuticals\u516c\u53f8\u5408\u6210\u4e86\u4e00\u7cfb\u5217\u80c6\u9178\u884d\u751f\u7269\uff0c\u4f5c\u4e3a\u80c6\u9178\u53d7\u4f53NR1H4\u6fc0\u52a8\u5242\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u809d\u75c5\u3001\u80c3\u80a0\u75c5\u3001\u80be\u75c5\u3001\u5fc3\u8840\u7ba1\u75c5\u548c\u4ee3\u8c22\u6027\u75be\u75c5\u7b49\u3002\u5728\u8367\u5149\u7d20\u9176\u62a5\u544a\u8bd5\u9a8c\u4e2d\uff0c\u4ee3\u8868\u5316\u5408\u7269\u5bf9CHO\u7ec6\u80de\u7684NR1H4\u53d7\u4f53\u663e\u793a\u51fa\u6fc0\u52a8\u6d3b\u6027\uff08EC50 < 1 nM\uff09\u3002\uff08\u8be6\u89c1WO 2018152171\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                \n
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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \n

                                \u56fe\u4e3aWO 2018152171\u4e2d\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u8840\u6db2\u53ca\u51dd\u8840\u75be\u75c5<\/p>\n<\/section>\n<\/section>\n

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                                <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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                                2018\u5e749\u670821\u65e5\uff0cPharming \u516c\u53f8\u6536\u5230FDA\u5173\u4e8eRuconest\u7684\u5b8c\u5168\u56de\u590d\u4fe1<\/span><\/p>\n

                                Pharming\u516c\u53f8\u6536\u5230FDA\u5173\u4e8e\u65b0\u836fRuconest\u8865\u5145BLA\u7684\u5b8c\u5168\u56de\u590d\u4fe1\u3002\u8be5\u7533\u8bf7\u8bd5\u56fe\u5c06\u5bf9\u9057\u4f20\u6027\u8840\u7ba1\u6027\u6c34\u80bf\uff08HAE\uff09\u60a3\u8005\u7684\u9884\u9632\u52a0\u5165\u9002\u5e94\u75c7\u8303\u56f4\u30022017\u5e7411\u6708\uff0c\u5728\u5b8c\u6210Ruconest\u5bf9HAE\u9884\u9632\u4f5c\u7528\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5e76\u5f97\u5230FDA\u7684\u53cd\u9988\u540e\uff0cPharming\u516c\u53f8\u63d0\u4ea4\u4e86\u8be5\u8865\u5145BLA\u7533\u8bf7\uff08\u8be6\u89c12017\u5e7411\u670827\u65e5\u7684BioWorld Science\uff09\u3002\u8fd9\u9879II\u671f\u7814\u7a76\u5305\u62ec\u4e86\u4e00\u4e2a\u5f00\u653e\u6807\u7b7e\u8bd5\u9a8c\u548c\u4e00\u4e2a\u968f\u673a\u53cc\u76f2\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\uff0c\u5171\u8fdb\u884c\u4e3a\u671f4-8\u5468\u7684\u6cbb\u7597\u4ee5\u8bc1\u660e\u8be5\u836f\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u30022018\u5e741\u6708\uff0cFDA\u57fa\u4e8e\u8be5\u7533\u8bf7\u5df2\u7ecf\u8db3\u591f\u5b8c\u6574\u5bf9\u8be5II\u671f\u7814\u7a76\u6570\u636e\u8fdb\u884c\u4e86\u5b9e\u8d28\u5ba1\u67e5\uff08\u8be6\u89c12018\u5e741\u670817\u65e5\u7684BioWorld Science\uff09\u3002\u7136\u800c\uff0c\u6839\u636e\u5ba1\u67e5\u7ed3\u679c\uff0cFDA\u8981\u6c42\u8fdb\u884c\u66f4\u591a\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u8fdb\u4e00\u6b65\u8bc4\u4f30Ruconest\u5728\u9884\u9632\u75be\u75c5\u65b9\u9762\u7684\u6709\u6548\u6027\u3002\uff08Pharming\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u547c\u5438\u7cfb\u7edf\u75be\u75c5<\/p>\n<\/section>\n<\/section>\n

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                                2018\u5e749\u670817\u65e5\uff0cPirfenidone\u5438\u5165\u5242\u7684\u4e34\u5e8aI\u671f\u6570\u636e\u516c\u5e03<\/span><\/p>\n

                                Avalyn\u5236\u836f\u516c\u53f8\u7684\u7814\u7a76\u4eba\u5458\u5728\u5065\u5eb7\u5fd7\u613f\u8005\u3001\u5438\u70df\u8005\u548c\u7279\u53d1\u6027\u80ba\u7ea4\u7ef4\u5316\uff08IPF\uff09\u60a3\u8005\u4e2d\u8fdb\u884c\u4e86pirfenidone\uff08\u5421\u975e\u5c3c\u916e\uff0cGP-101\uff09\u96fe\u5316\u5242\u7684\u4e34\u5e8aI\u671f\u5242\u91cf\u722c\u5761\u7814\u7a76\u3002\u8be5\u5438\u5165\u5236\u5242\u8bbe\u8ba1\u76ee\u7684\u662f\u63d0\u4f9b\u6709\u6548\u5242\u91cf\u7684\u5316\u5408\u7269\uff0c\u540c\u65f6\u907f\u514d\u5168\u8eab\u66b4\u9732\u548c\u53e3\u670d\u9020\u6210\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002\u5728\u5927\u9f20\u4e2d\u8fdb\u884c\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u6d4b\u8bd5\u4e86\u8be5\u5236\u5242\u7684\u6709\u6548\u6027\u3002<\/p>\n


                                <\/p>\n

                                \u6bcf\u65e5\u6216\u6bcf\u5468\u4e00\u6b21\u7684\u5927\u9f20\u7ed9\u836f\u540e\uff0c\u5728\u547c\u5438\u9053\u4e0a\u76ae\u6db2\uff08ELF\uff09\u4e2d\u68c0\u6d4b\u523030s\u7684\u5feb\u901f\u534a\u8870\u671f\uff0c\u8868\u660e\u6cbb\u7597\u80ba\u635f\u4f24\u7684\u6709\u6548\u6027\u662f\u7531\u4e8eCmax\u800c\u4e0d\u662fAUC\u3002\u72d7\u548c\u5927\u9f20\u768428\u5929\u6bd2\u7406\u5b9e\u9a8c\u8868\u660e\u8be5\u836f\u5b89\u5168\u6027\u826f\u597d\uff1b\u5728\u7ef5\u7f8a\u6a21\u578b\u4e2d\u89c2\u5bdf\u5230\u534a\u8870\u671f\u4e3a8-9\u5206\u949f\u3002I\u671f\u7814\u7a76\u5171\u670944\u540d\u53d7\u8bd5\u8005\u88ab\u5206\u4e3a6\u7ec4\uff08\u5b89\u6170\u5242\u7ec4\u6bcf\u7ec42\u4eba\uff1b\u7ed9\u836f\u7ec4\u6bcf\u7ec46\u4eba\uff09\u30021-3\u7ec4\u4f9d\u6b21\u63a5\u53d7\u5355\u6b21\u5242\u91cf25\u300150\u6216100 mg\u7684\u836f\u7269\uff0c4\u7ec4\u63a5\u53d7100 mg\u7ed9\u836f\u540e\u8fdb\u884c\u652f\u6c14\u7ba1\u80ba\u6ce1\u704c\u6d17\u7528\u4ee5\u6d4b\u91cfELF\u7684\u836f\u7269\u6d53\u5ea6\uff0c5\u7ec4\u548c6\u7ec4\u5206\u522b\u4e3a\u5438\u70df\u8005\u548cIPF\u60a3\u8005\u7ec4\u6210\uff0c\u5747\u63a5\u53d7100 mg\u5242\u91cf\u3002\u8be5\u5236\u5242\u4e3a12.5 mg\/mL\u7684\u5421\u975e\u5c3c\u916e\uff0c150 mmolNaCl\u548c\u7cd6\u7cbe\uff08\u63a9\u76d6\u82e6\u5473\uff09\u7ec4\u6210\uff0c\u901a\u8fc7PARI eflow\u7535\u5b50\u96fe\u5316\u5668\u8f93\u9001\u3002<\/p>\n


                                <\/p>\n

                                \u5b89\u5168\u6027\u7ed3\u679c\u663e\u793a\uff0c\u5728\u5404\u81ea\u961f\u5217\u4e2d\u7684\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u5206\u522b\u4e3a3\u30013\u30013\u30011\u30011\u548c2\u4f8b\uff0c\u5927\u591a\u4e3a\u4e2d\u5ea6\u6216\u8f7b\u5ea6\u3002\u4e3b\u8981\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u54b3\u55fd\uff08n = 1\u30011\u30013\u30011\u30011\u548c1)\u3002\u5927\u591a\u6570\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u5728IPF\u7ec4\uff0c\u4ed6\u4eec\u4e2d\u67091\u4f8b\u8f7b\u5fae\u54b3\u55fd\uff0c\u7729\u6655\u548c\u5636\u54d1\uff0c1\u4f8b\u4e2d\u5ea6\u5934\u75db\u3002\u7528\u836f\u5bf9FEV2\u548c\u8840\u6c27\u6d4b\u5b9a\u65e0\u5f71\u54cd\u3002\u836f\u4ee3\u52a8\u529b\u5b66\u6570\u636e\u663e\u793a\uff0c\u5728\u5c3f\u6db2\u4e2d\u56de\u6536\u7684\u7fa7\u57fapirfenidone\u5360\u636e\u4e8698%\u7684pirfenidone\u4ee3\u8c22\u4ea7\u7269\uff0c\u5168\u8eab\u5438\u6536\u7387\u5e73\u5747\u4e3a45%\uff08\u5728\u6700\u521d\u7684\u4e24\u4e2a6h\u6d4b\u5b9a\uff09\u3002Ae0-24h\u5206\u522b\u4e3a10.4\u300111.1\u300149.0\u300140.2\u300146.7\u548c42.2\uff1b\u5e73\u5747Cmax\u4e3a202\u3001292\u3001803\u30011370\u30011016\u548c1026 mcg\/mL\uff1b\u5e73\u5747t1\/2\u5206\u522b\u4e3a2.48\u30013.21\u30012.34\u30012.53\u30012.01\u548c3.87h\u3002\u5438\u5165\u5242\u7684\u5e73\u5747ELF Cmax\u4e3a135.9 mcg\/mL\uff0c\u5e73\u5747AUC\u4e3a54.5 mg.h\/L\uff0c\u800c\u53e3\u670d\u5236\u5242\u5206\u522b\u4e3a3.9 mcg\/mL\u548c29.7 mg\u2022h\/L\uff0c\u5373\u5438\u5165\u5242\u7684AUC\u4e3a\u53e3\u670d\u7684180%\uff0cCmax\u5927\u7ea6\u662f\u53e3\u670d\u5242\u768435\u500d\u3002100 mg\u5438\u5165\u5242\u7684\u4f53\u5916IC50\u7ea6\u4e3a25 mcg\/mL\uff0c\u4f53\u5185ED50\u7ea6\u4e3a100 mcg\/mL\u3002\u5728\u8840\u6d46\u4e2d\uff0c\u5438\u5165\u5242\u7684Cmax\u548cAUC\u5747\u8fdc\u4f4e\u4e8e\u53e3\u670d\uff081.7 vs. 7.9 mcg\/mL\u548c4.0 vs. 59.3 mcg.h \/ L\uff09\u3002<\/p>\n


                                <\/p>\n

                                \u5728\u66b4\u9732\u91cf\u65b9\u9762\uff0c\u5438\u5165\u5242\u7684\u5168\u8eab\u66b4\u9732\u91cf\u4ec5\u6709\u53e3\u670d\u5242\u76841\/16\uff0840 vs. 680mg\uff09\uff0c\u5438\u6536\u7387\u4e5f\u66f4\u4f4e\uff08\u7ea640% vs. 85%\uff09\u3002\u8fd9\u4e9b\u6570\u636e\u5728IPF\u60a3\u8005\u548c\u5065\u5eb7\u53d7\u8bd5\u8005\u4e2d\u662f\u76f8\u4f3c\u7684\uff0c\u6570\u636e\u53ef\u4ee5\u7528\u6765\u9884\u6d4bIPF\u60a3\u8005\u7684ELF\u6c34\u5e73\u3002\u4e0a\u8ff0\u6570\u636e\u652f\u6301\u5438\u5165\u5242\u5421\u975e\u5c3c\u916e\u4f5c\u4e3aIPF\u60a3\u8005\u7684\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6848\u3002\uff08Montgomery, A. et al. 28th AnnuCongrEurRespirSoc (ERS) (Sept 15-19, Paris) 2018, Abst OA266\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                \n
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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
                                \n
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                                \u56fe\u4e3aPirfenidone\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u4ee3\u8c22\u7c7b\u75be\u75c5<\/p>\n<\/section>\n<\/section>\n

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                                2018\u5e749\u670827\u65e5\uff0c\u65b0\u5f00\u53d1\u7684ISOD\u5c0f\u9f20\u6a21\u578b\u53ef\u7528\u6765\u6a21\u62df\u4eba\u7c7b\u75be\u75c5<\/span><\/p>\n

                                \u8bb8\u591a\u4ee3\u8c22\u7c7b\u75be\u75c5\uff0c\u5982\u4e9a\u786b\u9178\u76d0\u6c27\u5316\u9176\u7f3a\u4e4f\u75c7\uff08ISOD\uff09\u6216\u94bc\u8f85\u56e0\u5b50\u7f3a\u4e4f\u75c7\uff08MoCD\uff09\uff0c\u5df2\u77e5\u4f1a\u5bf9\u5927\u8111\u4ea7\u751f\u5f71\u54cd\uff0c\u751a\u81f3\u4e0e\u65e9\u901d\u6709\u5173\u3002ISOD\u662f\u7531\u7f16\u7801\u4e9a\u786b\u9178\u76d0\u6c27\u5316\u9176\u7684SUOX\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\u3002\u8fd9\u79cd\u9176\u662f\u4f9d\u8d56\u94bc\u8f85\u56e0\u5b50\u7684\uff0c\u5728\u534a\u80f1\u6c28\u9178\u548cH2S\u7684\u5206\u89e3\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u5c06\u4e9a\u786b\u9178\u76d0\u89e3\u6bd2\u4e3a\u786b\u9178\u76d0\u3002\u7814\u7a76\u4eba\u5458\u5229\u7528CRISPR\/Cas9\u6280\u672f\u5efa\u7acb\u4e86ISOD\u5c0f\u9f20\u6a21\u578b\uff08SUOX-knockout mouse model [SUOX ko\/ko]\uff09\uff0c\u7814\u7a76\u4e86ISOD\u5bf9\u534a\u80f1\u6c28\u9178\u548cH2S\u4ee3\u8c22\u7684\u5f71\u54cd\u3002\u5b9e\u9a8c\u89c2\u5bdf\u5230SUOX ko\/ko\u5c0f\u9f20\u7684\u5bff\u547d\u7f29\u77ed\u81f39\u5929\uff0c\u4f53\u91cd\u548c\u751f\u957f\u505c\u6ede\u57283g\u3002MRI\u626b\u63cf\u663e\u793a\u5176\u8111\u5bb9\u91cf\u51cf\u5c11\uff0c\u8111\u5f62\u6001\u6539\u53d8\u3002\u8111\u5185\u53c2\u4e0e\u534a\u80f1\u6c28\u9178\u4ee3\u8c22\u7684\u9176\u8868\u8fbe\u6c34\u5e73\u65e0\u53d8\u5316\uff0c\u800c\u809d\u3001\u80be\u5185\u7684\u534a\u80f1\u6c28\u9178\u53cc\u6c27\u9176\u548c\u5929\u51ac\u6c28\u9178\u8f6c\u6c28\u9176\u8868\u8fbe\u53d1\u751f\u53d8\u5316\u3002\uff08Kohl, J.B. et al. AnnuSympSoc Study Inborn Errors Metab (SSIEM) (Sept 4-7, Athens) 2018, Abst P-141\uff09\u3002<\/p>\n

                                 <\/p>\n

                                2018\u5e749\u670812\u65e5\uff0c\u53cc\u6548sHE\u6291\u5236\u5242 \/ PPAR-gamma\u6fc0\u52a8\u5242\u5bf9\u5927\u9f20\u4ee3\u8c22\u7efc\u5408\u75c7\u548c\u7cd6\u5c3f\u75c5\u6709\u6cbb\u7597\u4f5c\u7528<\/span><\/p>\n

                                \u4ee3\u8c22\u7efc\u5408\u75c7\u662f\u4e16\u754c\u8303\u56f4\u5185\u5f71\u54cd\u5fc3\u8840\u7ba1\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u7684\u666e\u904d\u75be\u75c5\uff0c\u5e76\u4e0e\u80a5\u80d6\u3001\u9ad8\u8840\u538b\u3001\u9ad8\u8102\u8840\u75c7\u548c\u80f0\u5c9b\u7d20\u62b5\u6297\u6709\u5173\u3002\u6b64\u5916\uff0c\u4ee3\u8c22\u7efc\u5408\u75c7\u60a3\u8005\u7f79\u60a32\u578b\u7cd6\u5c3f\u75c5\u3001\u80be\u75c5\u548c\u809d\u75c5\u7684\u98ce\u9669\u4e5f\u66f4\u9ad8\u3002<\/p>\n


                                <\/p>\n

                                \u5728\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u5a01\u65af\u5eb7\u8f9b\u533b\u5b66\u9662\u548c\u6cd5\u5170\u514b\u798f\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5728\u4e34\u5e8a\u524d\u52a8\u7269\u6a21\u578b\u4e2d\u5bf9\u5316\u5408\u7269RB-394\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002RB-394\u662f\u4e00\u79cd\u65b0\u578b\u5206\u5b50\uff0c\u5177\u6709\u5bf9\u6297\u4ee3\u8c22\u7efc\u5408\u75c7\u548c2\u578b\u7cd6\u5c3f\u75c5\u7684\u53cc\u91cd\u4f5c\u7528\u3002\u5b83\u662f\u4e00\u79cd\u65b0\u578b\u7684\u53cc\u8c03\u5236\u5668\uff0c\u53ef\u4f5c\u4e3a\u53ef\u6eb6\u6027\u73af\u6c27\u5316\u7269\u6c34\u89e3\u9176sHE\u7684\u6291\u5236\u5242\u548cPPAR-gamma\u6fc0\u52a8\u5242\u3002\u5728\u4ee3\u8c22\u7efc\u5408\u75c7\u7684\u81ea\u53d1\u6027\u9ad8\u8840\u538b\u5927\u9f20\u6a21\u578b\u4e2d\uff0cRB-394\u53ef\u4ee5\u9884\u9632\u9ad8\u8840\u538b\u3001\u9ad8\u8102\u8840\u75c7\u3001\u80f0\u5c9b\u7d20\u62b5\u6297\u548c\u80be\u635f\u4f24\u3002\u53e3\u670d\u5316\u5408\u726910 mg\/kg\u6301\u7eed8\u5468\uff0c\u80fd\u591f\u6539\u55842\u578b\u7cd6\u5c3f\u75c5ZSF1\u5927\u9f20\u6a21\u578b\u7684\u8840\u7cd6\u7a33\u6001\uff0c\u964d\u4f4e\u9ad8\u8102\u8840\u75c7\u3001\u8840\u538b\u3001\u809d\u786c\u5316\u548c\u80be\u635f\u4f24\u3002<\/p>\n


                                <\/p>\n

                                \u76f8\u53cd\uff0c\u4f9d\u90a3\u666e\u5229\uff0810mg\/kg\u6bcf\u5929\uff09\u5bf9ZSF1\u5927\u9f20\u7684\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8102\u8840\u75c7\u548c\u809d\u529f\u80fd\u4e0d\u5168\u75c7\u72b6\u65e0\u79ef\u6781\u4f5c\u7528\u3002RB-394\u8fd8\u53ef\u4ee5\u6539\u5584\u80a5\u80d6\u7cd6\u5c3f\u75c5ZSF1\u5927\u9f20\u7684\u7cd6\u5c3f\u75c5\u80be\u75c5\uff0c\u800c\u4f9d\u90a3\u666e\u5229\u7684\u4f5c\u7528\u5fae\u5f31\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u65b0\u578b\u53cc\u6548\u7684sHE\u6291\u5236\u5242 \/ PPAR-gamma\u6fc0\u52a8\u5242RB-394\u6709\u671b\u7528\u4e8e\u9776\u5411\u6cbb\u7597\u4ee3\u8c22\u7efc\u5408\u75c7\u53ca\u5176\u591a\u79cd\u5371\u9669\u56e0\u7d20\uff0c\u540c\u65f6\u6216\u53ef\u4f5c\u4e3a\u964d\u7cd6\u5242\u6cbb\u7597\u7cd6\u5c3f\u75c5\u53ca\u5176\u5e76\u53d1\u75c7\u3002\uff08Khan, M.A.H. et al. Diabetologia 2018, Advanced publication\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u56fe\u4e3aRB-394\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u514d\u75ab\u8c03\u8282\u5242<\/p>\n<\/section>\n<\/section>\n

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                                2018\u5e749\u67087\u65e5\uff0cPI3Kdelta\u4e0e\u81ea\u8eab\u514d\u75ab\u76f8\u5173<\/span><\/p>\n

                                \u78f7\u8102\u9170\u808c\u91874,5\u4e8c\u78f7\u9178\u6fc0\u91763\u50ac\u5316\u4e9a\u57fa\uff08PI3Kdelta\uff09\u4f1a\u5728\u67d0\u4e9b\u764c\u75c7\u4e2d\u8fc7\u5ea6\u6d3b\u8dc3\uff0c\u662fFDA\u6279\u51c6\u7684\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u836f\u7269Zydelig\uff08idelalisib\uff0c\u5409\u5229\u5fb7\u516c\u53f8\uff09\u7684\u4f5c\u7528\u9776\u70b9\uff0c\u4e5f\u662f\u836f\u7269duvelisib\uff08Verastem\uff09\u7684\u9776\u6807\u4e4b\u4e00\uff0c\u8be5\u836f\u76ee\u524d\u6b63\u5728\u88abFDA\u4f18\u5148\u5ba1\u8bc4\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3001\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\u548c\u6ee4\u6ce1\u6dcb\u5df4\u7624\u3002\u7136\u800c\uff0cPI3Kdelta\u7684\u67d0\u4e9b\u70b9\u7a81\u53d8\u4f1a\u5bfc\u81f4\u514d\u75ab\u7f3a\u9677\u7684\u201cPI3Kdelta\u6d3b\u5316\u7efc\u5408\u5f81\u201d(APDS)\u3002\u7f8e\u56fd\u56fd\u5bb6\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u5df2\u7ecf\u89e3\u5f00\u4e86\u8be5\u75be\u75c5\u5bfc\u81f4T\u7ec6\u80de\u548cB\u7ec6\u80de\u529f\u80fd\u7f3a\u9677\u7684\u5206\u5b50\u673a\u5236\u3002\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0cAPDS\u7684\u7279\u5f81\u662f\u8f85\u52a9\u6027T\u7ec6\u80de\u548c\u751f\u53d1\u4e2d\u5fc3B\u7ec6\u80de\u7684\u6570\u91cf\u589e\u52a0\uff0c\u7531\u6b64\u4ea7\u751f\u7684\u5f02\u5e38\u514d\u75ab\u53cd\u5e94\u4f34\u968f\u7740\u5bf9\u80a0\u9053\u7ec6\u83cc\u7684\u53cd\u5e94\u589e\u52a0\u4ee5\u53ca\u5171\u751f\u5fae\u751f\u7269\u523a\u6fc0\u7684\u81ea\u8eab\u6297\u4f53\u7684\u5e7f\u6cdb\u589e\u52a0\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5c3d\u7ba1\u5bc4\u4e3b\u7684\u4f53\u6db2\u514d\u75ab\u53d7\u5230\u5171\u751f\u83cc\u7fa4\u7684\u523a\u6fc0\uff0c\u4f46\u9002\u5f53\u7684\u8c03\u63a7PI3Kdelta\u5bf9\u4e8e\u5bc4\u4e3b\u7684\u4f53\u6db2\u514d\u75ab\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002\uff08Preite, S. et al. Nat Immunol 2018, 19(9): 986\uff09\u3002<\/p>\n

                                 <\/p>\n

                                2018\u5e749\u67085\u65e5\uff0c\u4e2d\u56fd\u533b\u7a76\u5f00\u53d1\u4e2d\u5fc3\u53d1\u73b0\u65b0\u578b\u7684BTK\u6291\u5236\u5242<\/span><\/p>\n

                                \u4e2d\u56fd\u533b\u7a76\u5f00\u53d1\u4e2d\u5fc3\u53d1\u73b0\u4e86\u4e00\u7c7b\u65b0\u578b\u7684\u5421\u54af\u5e76\u6742\u82b3\u57fa\u7c7bBTK\u6291\u5236\u5242\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u708e\u75c7\uff0c\u80bf\u7624\u548c\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u75be\u75c5\u3002\u4ee3\u8868\u5316\u5408\u7269BTK-030\uff0830 mg\/kg \uff0c\u9694\u65e5\u53e3\u670d21\u5929\uff09\u5728\u4e8c\u578b\u80f6\u539f\u8bf1\u5bfc\u7684DBA\/1J\u5c0f\u9f20\u4e2d\u80fd\u591f\u663e\u8457\u964d\u4f4e\u5173\u8282\u708e\u8bc4\u5206\u3002\uff08\u8be6\u89c1WO 2018145525\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u56fe\u4e3aBTK-030\u7ed3\u6784<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u611f\u67d3\u7c7b\u75be\u75c5<\/span><\/p>\n<\/section>\n<\/section>\n

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                                2018\u5e749\u670825\u65e5\uff0cThiomannosides\uff1a\u4e00\u79cd\u65b0\u7684\u53e3\u670dFimH\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u6ccc\u5c3f\u9053\u611f\u67d3<\/span><\/p>\n

                                \u5c3f\u8def\u611f\u67d3\u4e3b\u8981\u7531\u5c3f\u8def\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\uff08UPEC\uff09\u5f15\u8d77\uff0c\u5728\u4e16\u754c\u8303\u56f4\u5bf9\u5987\u5973\u6784\u6210\u91cd\u5927\u7684\u5065\u5eb7\u8d1f\u62c5\uff0c\u6bcf\u5e74\u62a5\u544a\u7684\u75c5\u4f8b\u7ea62000\u4e07\u4f8b\u3002\u7531\u4e8e\u590d\u53d1\u6027\u611f\u67d3\u7684\u65e5\u76ca\u6d41\u884c\u548c\u8010\u6297\u751f\u7d20\u83cc\u682a\u7684\u51fa\u73b0\uff0c\u8feb\u5207\u9700\u8981\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u7b2c\u4e00\u4e09\u5171\u5236\u836f\u516c\u53f8\u65e5\u524d\u62a5\u9053\u4e86\u4e00\u7c7bthiomannosides\u5316\u5408\u7269\u4f5c\u4e3a\u53e3\u670d\u6709\u6548\u7684FimH\u6291\u5236\u5242\u7684\u5408\u6210\u548c\u6d3b\u6027\u8bc4\u4f30\u3002FimH\u662f\u4e00\u79cd\u7518\u9732\u805a\u7cd6\u7279\u5f02\u6027\u51dd\u96c6\u7d20\uff0c\u4f4d\u4e8e\u7ec6\u83cc\u83cc\u6bdb\u9876\u7aef\uff0c\u4ecb\u5bfc\u7ec6\u83cc\u5728\u5c3f\u8def\u4e0a\u76ae\u7684\u521d\u59cb\u7c98\u9644\u3002\u76ee\u524d\u62a5\u9053\u7684\u51e0\u79cdFimH\u6291\u5236\u5242\u5747\u6709\u4f4e\u8840\u6d46\u66b4\u9732\u548c\u4f4e\u751f\u7269\u5229\u7528\u5ea6\u7b49\u7f3a\u70b9\u3002\u65b0\u578b\u5316\u5408\u7269\u542b\u6709S-\u7cd6\u82f7\u952e\uff0c\u5728\u53e3\u670d\u7ed9\u836f\u65f6\u80fd\u591f\u6539\u5584\u5c0f\u9f20\u7684\u4ee3\u8c22\u7a33\u5b9a\u6027\u548c\u8840\u6d46\u66b4\u9732\u91cf\u3002\u5176\u4e2d\uff0c\u4ee3\u8868\u5316\u5408\u7269I\u80fd\u591f\u6291\u5236\u751f\u7269\u819c\u7684\u5f62\u6210\u5e76\u7834\u574f\u9884\u5f62\u6210\u7684\u751f\u7269\u819c\u3002\u6b64\u5916\uff0c\u5316\u5408\u7269I\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u663e\u793a\u4e86\u5c3f\u8def\u611f\u67d3\u7684\u9884\u9632\u6548\u679c\u3002\u7efc\u4e0a\uff0c\u8fd9\u7c7b\u65b0\u578b\u7684FimH\u6291\u5236\u5242\u5177\u6709\u826f\u597d\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u4ee5\u53ca\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u6d3b\u6027\uff0c\u6709\u671b\u8fdb\u884c\u8fdb\u4e00\u6b65\u5f00\u53d1\u3002\uff08Sattigeri, J.A. et al. Bioorg Med Chem Lett 2018, 28(17): 2993\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u4ee3\u8868\u5316\u5408\u7269I\u7684\u7ed3\u6784<\/span><\/p>\n

                                 <\/p>\n

                                2018\u5e749\u670819\u65e5\uff0cFDA\u6279\u51c6Utility\u516c\u53f8\u7684mecillinam\u548cpivmecillinam\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76<\/span><\/p>\n

                                FDA\u5df2\u7ecf\u6279\u51c6\u4e86\u7f8e\u897f\u6797\uff08\u6ce8\u5c04\u7528\uff0cmecillinam\uff09\u548c\u5339\u7f8e\u897f\u6797\uff08\u53e3\u670d\u524d\u836f\uff0cpivmecillinam\uff09\u7684IND\u7533\u8bf7\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u6742\u6027\u5c3f\u8def\u611f\u67d3\uff08cUTI\uff09\u548c\u975e\u590d\u6742\u6027\u5c3f\u8def\u611f\u67d3\uff08uUTI\uff09\u3002\u4eca\u5e745\u6708\uff0cUtility\u516c\u53f8\u4e0eLeo Pharma\u516c\u53f8\u5c31mecillinam\u548cpivmecillinam\u7684\u5168\u90e8\u6570\u636e\u7b7e\u7f72\u4e86\u72ec\u5bb6\u6388\u6743\u534f\u8bae\uff0c\u8fd9\u4e24\u79cd\u836f\u7269\u5df2\u5728\u6b27\u6d32\u4f7f\u7528\u4e86\u8d85\u8fc740\u5e74\u3002\u8fd9\u4e24\u79cd\u836f\u7269\u90fd\u5df2\u88abFDA\u6307\u5b9a\u4e3a\u590d\u6742\u6027\u5c3f\u8def\u611f\u67d3\u9002\u7528\u7684\u5408\u683c\u4f20\u67d3\u75c5\u4ea7\u54c1\uff08QIDP\uff09\uff0c\u5339\u7f8e\u897f\u6797\u540c\u65f6\u88ab\u6307\u5b9a\u4e3a\u975e\u590d\u6742\u6027\u5c3f\u8def\u611f\u67d3\u9002\u7528\u7684QIDP\u3002\uff08Utility\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u4e0a\u56fe\u4e3a\u5339\u7f8e\u897f\u6797\u76d0\u9178\u76d0\u7ed3\u6784<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u4e0a\u56fe\u4e3a\u7f8e\u897f\u6797\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \u808c\u8089\u9aa8\u9abc\u4e0e\u7ed3\u7f14\u7ec4\u7ec7\u75be\u75c5<\/p>\n<\/section>\n<\/section>\n

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                                2018\u5e749\u670812\u65e5\uff0cFilgotinib\u7528\u4e8e\u6cbb\u7597\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7684FINCH 2\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9<\/span><\/p>\n

                                \u5409\u5229\u5fb7\u516c\u53f8\u4e0eGalapagos\u516c\u53f8\u5ba3\u5e03\u4e00\u9879\u9488\u5bf9\u836f\u7269Filgotinib\u7684\u540d\u4e3aFINCH 2\u7684\u5168\u7403\u6027\u3001\u968f\u673a\u3001\u6709\u5b89\u6170\u5242\u5bf9\u7167\u7684III\u671f\u7814\u7a76\u8fbe\u5230\u4e86\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\u3002\u8be5\u836f\u62df\u7528\u4e8e\u7ecf\u751f\u7269\u5236\u54c1\u6cbb\u7597\u672a\u6108\u7684\u6210\u4eba\u4e2d\u5ea6\u5230\u4e25\u91cd\u6d3b\u8dc3\u7684\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3002<\/p>\n


                                <\/p>\n

                                \u5176\u4e3b\u8981\u7ec8\u70b9\u4e3a\u6cbb\u759712\u5468\u8fbe\u5230\u7f8e\u56fd\u98ce\u6e7f\u5b66\u4f1a20%\u7f13\u89e3\uff08ACR20\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\uff08filgotinib 100 mg\u7ec4\uff1a57.5%\uff1bfilgotinib 200 mg\u7ec4\uff1a66.0%\uff1b\u5b89\u6170\u5242\u7ec4\uff1a31.1%\uff09\uff08\u8be6\u89c1ClinicalTrials.gov\u7f16\u53f7NCT02873936\uff09\u3002\u5728\u7b2c12\u5468\u548c\u7b2c24\u5468\uff0c\u6bcf\u5929\u670d\u7528\u4e00\u6b21filgotinib 100\u6216200mg\u7684\u60a3\u8005\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u8fbe\u5230ACR50\u3001ACR70\u3001\u4f4e\u75be\u75c5\u6d3b\u8dc3\u6027\uff08LDA, DAS28[CRP] \u22643.2\uff09\u548c\u4e34\u5e8a\u7f13\u89e3\uff08DAS28[CRP] < 2.6\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\u663e\u8457\u66f4\u9ad8\u3002<\/p>\n


                                <\/p>\n

                                Filgotinib\u5728\u8bd5\u9a8c\u4e2d\u8868\u73b0\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e0e\u4e4b\u524d\u7684\u8bd5\u9a8c\u76f8\u6bd4\u6ca1\u6709\u65b0\u7684\u5b89\u5168\u98ce\u9669\u51fa\u73b0\u3002\u6cbb\u7597\u76f8\u5173\u7684\u4e0d\u826f\u4e8b\u4ef6\u548c\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u591a\u4e3a\u8f7b\u5ea6\u6216\u4e2d\u5ea6\u3002\u5b89\u6170\u5242\u7ec4\u3001100mg\u7ec4\u548c200mg\u7ec4\u5206\u522b\u67093.4%\u30015.2%\u548c4.1%\u7684\u60a3\u8005\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u7531\u4e0d\u826f\u4e8b\u4ef6\u800c\u7ec8\u6b62\u8bd5\u9a8c\u7684\u60a3\u8005\u6bd4\u4f8b\u5728\u5404\u4e2a\u7ec4\u4e2d\u4e5f\u76f8\u4f3c\u3002Filgotinib\u6bcf\u7ec4\u4e2d\u5747\u62a5\u544a\u4e862\u4f8b\u65e0\u5e76\u53d1\u75c7\u7684\u5e26\u72b6\u75b1\u75b9\u3002100mg\u7ec4\u53d1\u73b02\u4f8b\u4e0d\u826f\u5fc3\u8840\u7ba1\u4e8b\u4ef6\uff0c\u5b89\u6170\u5242\u7ec4\u67091\u4f8b\u86db\u7f51\u819c\u4e0b\u8154\u51fa\u8840\uff0c100 mg\u7ec4\u67091\u4f8b\u5fc3\u808c\u7f3a\u8840\u3002200 mg\u7ec4\u67091\u4f8b\u975e\u4e25\u91cd\u89c6\u7f51\u819c\u9759\u8109\u963b\u585e\uff0c\u65e0\u6df1\u9759\u8109\u8840\u6813\u6216\u80ba\u6813\u585e\u62a5\u544a\u3002\u8be5\u7814\u7a76\u4e2d\u6ca1\u6709\u6b7b\u4ea1\u3001\u6076\u6027\u80bf\u7624\u3001\u80c3\u80a0\u9053\u7a7f\u5b54\u6216\u5305\u62ec\u6d3b\u52a8\u6027\u7ed3\u6838\u75c5\u5728\u5185\u7684\u673a\u4f1a\u6027\u611f\u67d3\u62a5\u544a\u3002\u6b64\u5916\uff0c\u6b63\u5728\u8fdb\u884c\u7684FINCH 1\u548cFINCH 3\u8bd5\u9a8c\u5c06\u7528\u4e8e\u63a2\u7d22filgotinib\u5728\u5176\u4ed6\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u60a3\u8005\u7fa4\u4f53\u4e2d\u7684\u5e94\u7528\uff08ClinicalTrials.gov\u7f16\u53f7NCT02889796\u548cNCT02886728\uff09\u3002\uff08Gilead Sciences\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u56fe\u4e3aFilgotinib\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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                                2018\u5e749\u670825\u65e5\uff0cEPI-589\u7528\u4e8e\u6cbb\u7597\u808c\u840e\u7f29\u6027\u4fa7\u7d22\u786c\u5316\u75c7\u7684II\u671f\u7814\u7a76\u663e\u793a\u8111\u810a\u6db2\u548c\u8840\u6d46\u751f\u7269\u6807\u5fd7\u7269\u6539\u5584<\/span>
                                <\/p>\n

                                BioElectron Technology\u516c\u53f8\u6700\u8fd1\u5b8c\u6210\u4e86EPI-589\u9488\u5bf9\u808c\u840e\u7f29\u6027\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u60a3\u8005\u7684IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08ClinicalTrials.gov\u7f16\u53f7NCT02460679\uff09\u3002\u8fd9\u9879\u5f00\u653e\u6807\u7b7e\u7684\u7814\u7a76\u65e8\u5728\u8bc4\u4f30EPI-589\u5728\u63a5\u53d7\u8fc7\u836f\u7269\u6cbb\u7597\u7684ALS\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u7406\u5b66\u3002<\/p>\n


                                <\/p>\n

                                \u6b64\u5916\uff0c\u8be5\u8bd5\u9a8c\u65e8\u5728\u8bc6\u522b\u4e0eALS\u76f8\u5173\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u548c\u8840\u6db2\u751f\u7269\u6807\u5fd7\u7269\u3001\u6cbb\u7597\u9776\u6807\u548c\u4f5c\u7528\u673a\u5236\u3002\u5171\u670921\u540d\u53d7\u8bd5\u8005\u5728\u7f8e\u56fd\u76843\u4e2a\u5730\u70b9\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u53d7\u8bd5\u8005\u752830\u5929\u5efa\u7acb\u8d77\u57fa\u7ebf\u751f\u7269\u6807\u5fd7\u7269\u548c\u4e34\u5e8a\u72b6\u6001\uff0c\u7136\u540e\u4f7f\u7528EPI-589\u6cbb\u759790\u5929\uff0c\u505c\u836f\u540e\u518d\u968f\u8bbf3\u4e2a\u6708\u3002\u672c\u7814\u7a76\u8fbe\u5230\u4e86\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7684\u4e3b\u8981\u7ec8\u70b9\uff0c\u6ca1\u6709\u836f\u7269\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u6216\u5242\u91cf\u76f8\u5173\u7684\u6bd2\u6027\u95ee\u9898\u3002\u836f\u7269\u6cbb\u7597\u4e0e\u8111\u810a\u6db2\uff08CSF\uff09\u548c\u5df2\u77e5\u4e0e\u795e\u7ecf\u708e\u75c7\u548cALS\u75be\u75c5\u8fdb\u5c55\u76f8\u5173\u7684\u8840\u6d46\u751f\u7269\u6807\u5fd7\u7269\u7684\u663e\u8457\u6539\u5584\u6709\u5173\u3002\u4e00\u7cfb\u5217\u7684\u4e34\u5e8a\u8bc4\u4f30\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u836f\u7269\u6cbb\u7597\u80fd\u591f\u6709\u6548\u7684\u51cf\u6162\u7531ALS\u529f\u80fd\u8bc4\u5206\u91cf\u5ea6\u7684\u75be\u75c5\u8fdb\u5c55\uff0c\u6b64\u5916\u8fd8\u80fd\u6539\u5584\u60a3\u8005\u7684\u63e1\u529b\u548c\u541e\u54bd\u80fd\u529b\u3002<\/p>\n


                                <\/p>\n

                                \u76ee\u524d\u6b63\u5728\u8ba1\u5212\u4e0e\u5b89\u6170\u5242\u7ec4\u8fdb\u884c\u66f4\u957f\u671f\u7684\u540e\u7eed\u8bd5\u9a8c\u4ee5\u660e\u786e\u4e34\u5e8a\u83b7\u76ca\u3002EPI-589\u662f\u4e00\u79cd\u65b0\u578b\u53e3\u670d\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u5b83\u9776\u5411\u5728\u708e\u75c7\u8c03\u8282\u548c\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u8fc7\u7a0b\u4e2d\u81f3\u5173\u91cd\u8981\u6c27\u5316\u8fd8\u539f\u9176\u7cfb\u3002\u8be5\u836f\u6b63\u5728\u4e0eSumitomo Dainippon Pharma\u516c\u53f8\u5408\u4f5c\u5f00\u53d1\uff0c\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0cSumitomo Dainippon\u62e5\u6709\u8be5\u5316\u5408\u7269\u5728\u65e5\u672c\u548c\u5317\u7f8e\u7684\u8bb8\u53ef\u6743\u3002\u6b64\u5916\uff0cBioElectron\u516c\u53f8\u7684\u4e3b\u8981\u4e34\u5e8a\u5316\u5408\u7269EPI-743\uff08vatiquinone\uff09\u6b63\u5904\u4e8e\u6cbb\u7597\u7ebf\u7c92\u4f53\u75be\u75c5\u7684\u665a\u671f\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u3002\uff08BioElectron Technology\u516c\u53f8\u65b0\u95fb\u7a3f\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

                                \n
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                                \"\u3010BioWorld<\/section>\n<\/section>\n<\/section>\n
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                                \u56fe\u4e3aVatiquinone\u7ed3\u6784<\/p>\n

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                                \u79d1\u777f\u552f\u5b89\u5bf9\u672c\u6587\u7684\u5168\u90e8\u5185\u5bb9\u4ee5\u53ca\u53ef\u80fd\u9644\u5e26\u7684\u5168\u90e8\u8d44\u6599\u62e5\u6709\u5168\u90e8\u77e5\u8bc6\u4ea7\u6743\uff0c\u5e76\u53d7\u6cd5\u5f8b\u4fdd\u62a4\u3002\u7f51\u7edc\u8f6c\u8f7d\u3001\u7f16\u8bd1\u53ca\u5176\u4ed6\u5546\u4e1a\u4f7f\u7528\u8bf7\u8054\u7cfb\u5e02\u573a\u90e8\uff1ayili1@Clarivate.com
                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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                                <\/span><\/p>\n

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                                Clarivate Analytics \u836f\u7269\u65b0\u95fb<\/span><\/strong><\/span><\/p>\n


                                <\/p>\n

                                \u5468\u4e00\u81f3\u5468\u4e94\u52a8\u6001\u66f4\u65b0\u7684\u836f\u7269\u65b0\u95fb\u548cEMAIL\u8ddf\u8e2a\u63d0\u9192<\/span>
                                <\/p>\n


                                <\/span><\/p>\n

                                \u25a0 <\/span> \u6bcf\u5468\u4e00\u81f3\u4e94, Clarivate Analytics\u836f\u7269\u65b0\u95fb\uff08Clarivate Analytics BioWorld Science\uff09\u7cbe\u9009\u6700\u65b0\u3001\u6700\u91cd\u8981\u7684\u836f\u7269\u7814\u53d1\u65b0\u95fb\u5728\u7ebf\u53d1\u5e03\uff0c\u5e76\u4ee5\u7b80\u660e\u627c\u8981\u7684\u683c\u5f0f\u53d1\u9001\u63d0\u9192\u90ae\u4ef6\u81f3\u60a8\u7684\u90ae\u7bb1\uff0c\u5e2e\u52a9\u60a8\u5feb\u901f\u9501\u5b9a\u91cd\u8981\u7684\u65b0\u95fb\u4e8b\u4ef6\u3002<\/span><\/p>\n

                                \u25a0<\/span>  \u60a8\u53ef\u4ee5\u5728\u7ebf\u68c0\u7d22\u6211\u4eec\u6240\u6709\u7684\u65b0\u95fb\u8d44\u6e90\uff0c\u5e76\u8bbe\u5b9a\u68c0\u7d22\u6761\u4ef6\uff08\u9650\u5b9a\u65b0\u95fb\u53d1\u751f\u7684\u65f6\u95f4\u3001\u836f\u540d\u3001\u4e13\u5229\u53f7\u3001\u516c\u53f8\u3001\u5927\u5b66\u3001\u673a\u6784\u3001\u6cbb\u7597\u7c7b\u522b\/\u5206\u7ec4\u3001\u5316\u5408\u7269\u7c7b\u578b\u3001\u4fe1\u606f\u6e90\uff09\u627e\u5230\u4e0e\u60a8\u7814\u7a76\u76f8\u5173\u7684\u5185\u5bb9\u3002\u836f\u7269\u65b0\u95fb\uff08BioWorld Science\uff09\u5185\u5bb9\u53ef\u56de\u6eaf\u81f31996\u5e74\uff0c\u5e76\u53ef\u67e5\u770b\u5316\u5b66\u7ed3\u6784\u5f0f\u3002<\/span><\/p>\n


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                                \u836f\u7269\u65b0\u95fb\uff08BioWorld Science\uff09\u63d0\u4f9b\u5982\u4e0b\u5185\u5bb9\uff1a<\/span><\/p>\n

                                \u25a0<\/span>  \u4ece\u6d77\u91cf\u4fe1\u606f\u6e90\u4e2d\u603b\u7ed3\u51fa\u7684\u6458\u8981\u62a5\u544a\u3002<\/span><\/p>\n

                                \u25a0<\/span>  \u5728\u5168\u7403\u91cd\u8981\u4f1a\u8bae\u4e2d\u62ab\u9732\u7684\u65b0\u95fb\u4fe1\u606f\u3002<\/span><\/p>\n

                                \u25a0 <\/span> \u6bcf\u5468\u66f4\u65b0\u7684\u90ae\u4ef6\u63d0\u9192\u670d\u52a1\uff0c\u4ee5\u8868\u683c\u7684\u5f62\u5f0f\u544a\u77e5\u60a8\u8fdb\u5165\u4e34\u5e8a\u524d\u5f00\u53d1\u6700\u6709\u524d\u666f\u7684\u5316\u5408\u7269\u3001lead compounds\u548c\u6700\u65b0\u7684\u4f5c\u7528\u673a\u5236\u3002<\/span><\/p>\n

                                \u25a0<\/span>  \u6bcf\u5468\u66f4\u65b0\u7684\u90ae\u4ef6\u63d0\u9192\u670d\u52a1\uff0c\u544a\u77e5\u60a8\u5728\u7814\u836f\u7269\u7814\u53d1\u72b6\u6001\u7684\u53d8\u66f4\u3002<\/span><\/p>\n


                                <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

                                <\/span><\/p>\n


                                <\/p>\n<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


                                <\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

                                \u4e2d\u6587\u7ffb\u8bd1\uff1a\u963f\u6817\u535a\u58eb Daily Drug News \u5df2\u6b63\u5f0f\u66f4\u540d\u4e3aBioWorld Science \u5feb […]<\/p>\n","protected":false},"author":1,"featured_media":67642,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/67641"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=67641"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/67641\/revisions"}],"predecessor-version":[{"id":67656,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/67641\/revisions\/67656"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/67642"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=67641"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=67641"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=67641"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}