{"id":6789,"date":"2018-06-13T01:00:00","date_gmt":"2018-07-27T09:18:34","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e6%9c%80%e6%96%b0%e7%a0%94%e7%a9%b6%ef%bc%8c%e3%80%8c%e4%bc%9f%e5%93%a5%e3%80%8d%e7%ab%9f%e7%84%b6%e8%bf%98%e8%83%bd%e8%bf%99%e4%b9%88%e7%94%a8%ef%bc%81\/"},"modified":"2018-07-27T17:18:35","modified_gmt":"2018-07-27T09:18:35","slug":"%e6%9c%80%e6%96%b0%e7%a0%94%e7%a9%b6%ef%bc%8c%e3%80%8c%e4%bc%9f%e5%93%a5%e3%80%8d%e7%ab%9f%e7%84%b6%e8%bf%98%e8%83%bd%e8%bf%99%e4%b9%88%e7%94%a8%ef%bc%81","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/6789\/","title":{"rendered":"\u6700\u65b0\u7814\u7a76\uff0c\u300c\u4f1f\u54e5\u300d\u7adf\u7136\u8fd8\u80fd\u8fd9\u4e48\u7528\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1532683115.jpeg\" alt=\"\u6700\u65b0\u7814\u7a76\uff0c\u300c\u4f1f\u54e5\u300d\u7adf\u7136\u8fd8\u80fd\u8fd9\u4e48\u7528\uff01\" title=\"\u6700\u65b0\u7814\u7a76\uff0c\u300c\u4f1f\u54e5\u300d\u7adf\u7136\u8fd8\u80fd\u8fd9\u4e48\u7528\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">\u6bcf\u4e2a\u80bf\u7624\u79d1\u533b\u751f\u90fd\u77e5\u9053\uff0c\u764c\u75c7\u75c5\u4eba\u5728\u624b\u672f\u5207\u9664\u80bf\u7624\u4e4b\u540e\uff0c\u7531\u4e8e\u514d\u75ab\u529b\u4e0b\u964d\uff0c\u975e\u5e38\u5bb9\u6613\u5f15\u8d77\u6b8b\u4f59\u764c\u7ec6\u80de\u7684\u6269\u6563\u8f6c\u79fb\u3002\u56e0\u6b64\u901a\u5e38\u60c5\u51b5\u4e0b\u6211\u4eec\u4f1a\u6839\u636e\u5b9e\u9645\u75c5\u60c5\u7ed9\u672f\u540e\u60a3\u8005\u505a\u540e\u7eed\u7684\u653e\u5316\u7597\u4ee5\u8fbe\u5230\u964d\u4f4e\u764c\u75c7\u8f6c\u79fb\u590d\u53d1\u7684\u98ce\u9669\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">\u6700\u8fd1\uff0c\u5728\u8457\u540d\u533b\u5b66\u6742\u5fd7<em style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;Oncolmmunology&nbsp;<\/em>\u4e0a\u9762\u5c31\u6709\u4eba\u53d1\u8868\u4e86\u4e00\u7bc7\u6587\u7ae0\u8bf4\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7528\u300c\u4f1f\u54e5\u300d+\u300c\u6d41\u611f\u75ab\u82d7\u300d\u7adf\u53ef\u4ee5\u964d\u4f4e\u764c\u75c7\u60a3\u8005\u672f\u540e\u8f6c\u79fb\u7684\u98ce\u9669\uff01<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">\u8ba9\u6211\u4eec\u6765\u770b\u770b\u539f\u6587\u662f\u5982\u4f55\u63cf\u8ff0\u7684\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(127, 127, 127);box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<blockquote style=\"max-width: 100%;color: rgb(51, 51, 51);\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(127, 127, 127);box-sizing: border-box !important;word-wrap: break-word !important;\">Metastatic recurrence following surgery remains the single biggest cause of mortality in patients with solid tumors. We previously demonstrated that surgery-induced NK cell dysfunction contributes to progression of metastatic disease.<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(127, 127, 127);box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(127, 127, 127);box-sizing: border-box !important;word-wrap: break-word !important;\">There is accumulating evidence to suggest that PDE5 inhibitors could interfere with the suppressive functions of MDSC. In this report, we provide evidence that perioperative PDE5 inhibition reverses surgery-induced immunosuppression.<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(127, 127, 127);box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(127, 127, 127);box-sizing: border-box !important;word-wrap: break-word !important;\">Based on our preclinical data demonstrating that the perioperative administration of sildena\ufb01l in combination with in\ufb02uenza vaccine results in a greater reduction of lung tumor metastasis than either treatment alone and our ex vivo sildena\ufb01l patient studies.<\/span><\/p>\n<\/blockquote>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">\u8be5\u7814\u7a76\u56e2\u961f\u5728\u764c\u75c7\u5c0f\u9f20\u6a21\u578b\u4e0a\u9762\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u4ee5\u5c0f\u9f20\u80ba\u90e8\u8f6c\u79fb\u4f5c\u4e3a\u89c2\u5bdf\u6307\u6807\uff0c\u7ed3\u679c\u53d1\u73b0\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">\u672a\u63a5\u53d7\u624b\u672f\uff08\u5bf9\u7167\u7ec4\uff09\uff1a37\u5904\u8f6c\u79fb<\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">\u53ea\u63a5\u53d7\u624b\u672f\u7ec4\uff1a129\u5904\u8f6c\u79fb<\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">\u624b\u672f + \u52c3\u8d77\u529f\u80fd\u969c\u788d\u836f\u7269\u7ec4\uff1a24\u5904\u8f6c\u79fb<\/span><\/p>\n<\/li>\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">\u624b\u672f + \u52c3\u8d77\u529f\u80fd\u969c\u788d\u836f\u7269 + \u6d41\u611f\u75ab\u82d7\u7ec4\uff1a11\u5904\u8f6c\u79fb<\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e5f\u5c31\u662f\u8bf4\uff0c\u901a\u8fc7\u52c3\u8d77\u529f\u80fd\u969c\u788d\u836f\u7269\uff08\u897f\u5730\u62c9\u975e\u7b49\uff09+ \u6d41\u611f\u75ab\u82d7\uff0c\u53ef\u4ee5\u4f7f\u5f97\u764c\u75c7\u5c0f\u9f20\u672f\u540e\u8f6c\u79fb\u98ce\u9669\u5927\u5927\u964d\u4f4e\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">\u8be5\u7814\u7a76\u56e2\u961f\u8ba4\u4e3a\uff0c\u52c3\u8d77\u529f\u80fd\u969c\u788d\u836f\u7269 + \u6d41\u611f\u75ab\u82d7\u4e4b\u6240\u4ee5\u53ef\u4ee5\u8d77\u5230\u8fd9\u6837\u7684\u4f5c\u7528\uff0c\u662f\u56e0\u4e3a\u4ed6\u4eec\u53ef\u4ee5\u9776\u5411\u963b\u65ad \u9aa8\u9ad3\u884d\u751f\u6291\u5236\u7ec6\u80de\uff08MDSC\uff09\uff0c\u5e76\u5728\u56f4\u624b\u672f\u671f\u4fee\u590d\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK cell\uff09\u7684\u529f\u80fd\uff0c\u4ece\u800c\u53d1\u6325\u6297\u764c\u7684\u4f5c\u7528\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">\u76ee\u524d\uff0c\u8fd9\u9879\u7814\u7a76\u5df2\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u5e76\u4e14\u4f5c\u8005\u8868\u793a\uff0c\u5973\u6027\u60a3\u8005\u5728\u670d\u7528\u4f1f\u54e5\u540e\u5e76\u6ca1\u6709\u4ec0\u4e48\u526f\u4f5c\u7528\uff0c\u5bf9\u5979\u4eec\u7684\u6027\u529f\u80fd\u4e5f\u65e0\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd9\u79cd\u65b0\u7684\u6cbb\u7597\u6a21\u5f0f\u6709\u53ef\u80fd\u4e3a\u764c\u75c7\u7684\u590d\u53d1\u8f6c\u79fb\u5e26\u6765\u66f4\u591a\u6cbb\u7597\u7684\u5e0c\u671b\u3002\u4f46\u8981\u5f3a\u8c03\u7684\u662f\uff0c\u76ee\u524d\u8be5\u7814\u7a76\u8fd8\u5728\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u8bf7\u4e0d\u8981\u8f7b\u6613\u5c1d\u8bd5\u54e6\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"__bg_gif\"     style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress4-1532683115.gif\" alt=\"\u6700\u65b0\u7814\u7a76\uff0c\u300c\u4f1f\u54e5\u300d\u7adf\u7136\u8fd8\u80fd\u8fd9\u4e48\u7528\uff01\" title=\"\u6700\u65b0\u7814\u7a76\uff0c\u300c\u4f1f\u54e5\u300d\u7adf\u7136\u8fd8\u80fd\u8fd9\u4e48\u7528\uff01\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"color: rgb(51, 51, 51);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532683115.jpeg\" alt=\"\u6700\u65b0\u7814\u7a76\uff0c\u300c\u4f1f\u54e5\u300d\u7adf\u7136\u8fd8\u80fd\u8fd9\u4e48\u7528\uff01\" title=\"\u6700\u65b0\u7814\u7a76\uff0c\u300c\u4f1f\u54e5\u300d\u7adf\u7136\u8fd8\u80fd\u8fd9\u4e48\u7528\uff01\"  \/><\/span><\/p>\n<p><span style=\"color: rgb(255, 0, 0);\"><strong>\u5f80\u671f\u7cbe\u5f69<\/strong><\/span><\/p>\n<p><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231167&amp;idx=1&amp;sn=28235cb4fd7bb283cf83af16cc7d3a42&amp;chksm=84be7824b3c9f132888169756d6229bda5f6942392c2d5adf0678a7bd053afa3b48bf35d379d&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;\">\u4e00\u81f4\u6027\u8bc4\u4ef7\u76843\u5bb6\u4e0e3\u5e74<\/a><br  \/><\/p>\n<p><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652230701&amp;idx=1&amp;sn=ea702ea398a915207c0901323d96697a&amp;chksm=84be79f6b3c9f0e08013a45f74ccb18f77b2470d83a0b6a500591ffc2970fa796b24166bd325&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;\">\u6c47\u805a\u5357\u836f\u7275\u7ebf\u642d\u6865 &nbsp;\u6821\u4f01\u643a\u624b\u5171\u540c\u63a2\u7d22\u4eba\u624d\u57f9\u517b\u65b0\u6a21\u5f0f\u4e00\u4e00\u9996\u5c4aCRA\u4eba\u624d\u57f9\u8bad\u73ed\u7eaa\u5b9e<\/a><br  \/><\/p>\n<p><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231162&amp;idx=1&amp;sn=7b4cf87e991464cf2205db0c1293d26f&amp;chksm=84be7821b3c9f13739102fa0302f2743f323e9c92658af76d99cd548cb37cba12cd3c96b1193&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;\">\u540c\u5fc3\u7b51\u68a6\u2014\u2014\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u4e0a\u6d77\u6821\u53cb\u4f1a\u5e74\u4f1a\u4fa7\u8bb0<\/a><\/p>\n<p><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231647&amp;idx=3&amp;sn=5fba9662135ab180b69681e5baa7d2e7&amp;chksm=84be7a04b3c9f312ee31ea61f5ddb0a786a7408f1ab572755679c8dbde12386a65f054431511&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;\">\u6c47\u805a\u5357\u836f | \u6fb3\u5927\u5229\u4e9a\u836f\u54c1\u6ce8\u518c\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\u4ecb\u7ecd(\u7b2c\u4e8c\u6b21\u62a5\u540d\uff09<\/a><br  \/><\/p>\n<\/p>\n<p><br  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u6c47\u805a\u5357\u836f                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6bcf\u4e2a\u80bf\u7624\u79d1\u533b\u751f\u90fd\u77e5\u9053\uff0c\u764c\u75c7\u75c5\u4eba\u5728\u624b\u672f\u5207\u9664\u80bf\u7624\u4e4b\u540e\uff0c\u7531\u4e8e\u514d\u75ab\u529b\u4e0b\u964d\uff0c\u975e\u5e38\u5bb9\u6613\u5f15\u8d77\u6b8b\u4f59\u764c\u7ec6\u80de\u7684\u6269\u6563\u8f6c\u79fb\u3002\u56e0\u6b64\u901a\u5e38\u60c5 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6790,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/6789"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=6789"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/6789\/revisions"}],"predecessor-version":[{"id":6794,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/6789\/revisions\/6794"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/6790"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=6789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=6789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=6789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}