{"id":67914,"date":"2018-12-05T01:00:00","date_gmt":"2018-12-07T04:19:27","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/5329713f21\/"},"modified":"2018-12-07T12:19:28","modified_gmt":"2018-12-07T04:19:28","slug":"5329713f21","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/67914\/","title":{"rendered":"11\u6708\u5fc5\u770b\u7684\u91cd\u78c5\u7ea7\u7814\u7a76Top10"},"content":{"rendered":"
\n

\"11\u6708\u5fc5\u770b\u7684\u91cd\u78c5\u7ea7\u7814\u7a76Top10\"<\/p>\n


<\/p>\n


<\/p>\n

\n
\n
\n
\n
\n

\u8c37 \u541b \u8bf4<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5a74\u513f\u914d\u65b9\u5976\u7c89\u4e0d\u4ec5\u80fd\u5728\u8425\u517b\u65b9\u9762\u6a21\u62df\u6bcd\u4e73\uff0c\u800c\u4e14\u8fd8\u80fd\u5728\u5a74\u513f\u6d88\u5316\u9053\u4e2d\u6ecb\u517b\u7c7b\u4f3c\u80a0\u9053\u83cc\u7fa4\u7684\u751f\u957f\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

 \u91cd\u78c5\u7ea7\u7814\u7a76 <\/span><\/strong><\/span><\/strong><\/span>
<\/p>\n

\u6587\/T.shen<\/span><\/p>\n


<\/p>\n

\"11\u6708\u5fc5\u770b\u7684\u91cd\u78c5\u7ea7\u7814\u7a76Top10\"<\/p>\n

\u56fe\u7247\u6765\u6e90\uff1apinterest<\/span><\/p>\n


<\/p>\n

\n

Nat Genet\uff1a2018\u5e74\u8bfa\u5956\u4e4b\u540e\u79d1\u5b66\u5bb6\u4eec\u53c8\u53d1\u73b0\u514d\u75ab\u7597\u6cd5\u7684\u65b0\u578b\u9776\u70b9<\/span><\/strong><\/span><\/p>\n<\/blockquote>\n

doi\uff1a10.1038\/s41588-018-0251-4<\/span><\/p>\n


<\/p>\n

\u7ee72018\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u4e4b\u540e\uff0c\u5168\u7403\u5f88\u591a\u7814\u7a76\u4eba\u5458\u90fd\u5c06\u76ee\u5149\u8f6c\u79fb\u5230\u4e86\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u5f00\u53d1\u4e0a\u3002<\/span><\/p>\n


<\/p>\n

\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7<\/span>Nature Genetics<\/span><\/strong><\/span><\/em>\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u9ea6\u5409\u5c14\u5927\u5b66\u5065\u5eb7\u4e2d\u5fc3\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff1a<\/span><\/p>\n


<\/p>\n

\u4e00\u79cd\u540d\u4e3aTIM-3\u7684\u5206\u5b50\u5728\u673a\u4f53\u514d\u75ab\u53cd\u5e94\u7684\u8c03\u8282\u4e0a\u626e\u6f14\u7740\u5173\u952e\u89d2\u8272\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u79cd\u7279\u6b8a\u5206\u5b50\u6216\u6709\u671b\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u6f5c\u5728\u9776\u70b9\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u6cbb\u7597\u764c\u75c7\u548c\u5176\u5b83\u75be\u75c5\u7684\u65b0\u578b\u514d\u75ab\u7597\u6cd5\u3002<\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u8005\u53d1\u73b0\uff0c\u5f53TIM-3\u86cb\u767d\u529f\u80fd\u5904\u4e8e\u6291\u5236\u72b6\u6001\u6216\u5931\u6d3b\u65f6\uff0c\u673a\u4f53\u514d\u75ab\u7cfb\u7edf\u529f\u80fd\u5c31\u4f1a\u88ab\u5b8c\u5168\u201c\u91ca\u653e\u201d\uff0cT\u7ec6\u80de\u5c31\u4f1a\u5931\u63a7\u8fc7\u91cf\u8868\u8fbe\u3002<\/span><\/p>\n


<\/p>\n

\u4ece\u800c\u5f15\u53d1\u76ae\u4e0b\u8102\u819c\u708eT\u6dcb\u5df4\u7624\uff08LTSCP\uff0csubcutaneous panniculitis T lymphoma\uff09\uff0c\u8fd9\u79cd\u7279\u6b8a\u764c\u75c7\u8d77\u6e90\u4e8e\u6dcb\u5df4\u7ec6\u80de\u3002<\/span><\/p>\n


<\/p>\n

\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u8005\u5728\u8fd9\u79cd\u7efc\u5408\u5f81\u7684\u75be\u75c5\u8d77\u6e90\u5904\u53d1\u73b0\u4e86\u4e24\u79cd\u539f\u59cb\u7684\u7a81\u53d8\uff0c\u8fd9\u4e9b\u7a81\u53d8\u80fd\u76f4\u63a5\u5bf9TIM-3\u53d1\u6325\u4f5c\u7528\uff0c\u6291\u5236\u8be5\u5206\u5b50\u5728\u6dcb\u5df4\u7ec6\u80de\u8868\u9762\u8868\u8fbe\uff0c\u5e76\u653b\u51fb\u764c\u7ec6\u80de\u3002<\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u8005\u53d1\u73b0\uff0c\u8fd9\u79cd\u6dcb\u5df4\u7624\u76f8\u5173\u7684\u514d\u75ab\u53cd\u5e94\u7684\u8fc7\u5ea6\u6fc0\u6d3b\u8981\u6bd4\u4ed6\u4eec\u6700\u521d\u60f3\u8c61\u4e2d\u66f4\u4e3a\u666e\u904d\u3002<\/span><\/p>\n


<\/p>\n

\u76ee\u524d\u7814\u7a76\u4eba\u5458\u5728\u4e1c\u4e9a\u4eba\u3001\u6fb3\u5927\u5229\u4e9a\u4eba\u3001\u6ce2\u5229\u5c3c\u897f\u4e9a\u4eba\u53ca\u6b27\u6d32\u4eba\u8eab\u4e0a\u90fd\u53d1\u73b0\u4e86\u8fd9\u4e24\u79cd\u7a81\u53d8\u3002<\/span><\/p>\n


<\/p>\n

\u540c\u65f6\u7814\u7a76\u4eba\u5458\u8fd8\u5728\u8fd9\u4e9b\u4eba\u7fa4\u7684\u5144\u5f1f\u59d0\u59b9\u4e2d\u53d1\u73b0\u4e86\u76f8\u540c\u7684\u7f55\u89c1\u6dcb\u5df4\u7624\uff0c\u5f53\u8fdb\u884c\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u540e\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff1a<\/span><\/p>\n


<\/p>\n

\u6240\u6709\u60a3\u8005\u90fd\u643a\u5e26\u6709HAVCR2\u57fa\u56e0\u7684\u76f8\u540c\u57fa\u56e0\u7a81\u53d8\u3002<\/span><\/p>\n


<\/p>\n

\u8be5\u57fa\u56e0\u80fd\u7f16\u7801TIM-3\uff0c\u5176\u4f1a\u901a\u8fc7\u7236\u6bcd\u4eb2\u6765\u4f20\u9012\u3002<\/span><\/p>\n


<\/p>\n

\n

Nature \uff1a\u4e2d\u7f8e\u79d1\u5b66\u5bb6\u91cd\u78c5\u7ea7\u53d1\u73b0\uff01RNA\u7532\u57fa\u5316\u4fee\u9970\u6216\u80fd\u4fc3\u8fdb\u673a\u4f53\u5b66\u4e60\u548c\u8bb0\u5fc6\u8fc7\u7a0b<\/span><\/strong><\/span><\/p>\n<\/blockquote>\n

doi\uff1a10.1038\/s41586-018-0666-1   doi\uff1a10.1016\/j.cell.2015.04.010<\/span><\/p>\n


<\/p>\n

RNA\u643a\u5e26\u7740DNA\u7f16\u7801\u7684\u6307\u4ee4\u7247\u6bb5\uff0c\u5176\u80fd\u643a\u5e26\u86cb\u767d\u8d28\u7684\u4ea7\u751f\u4ece\u800c\u5b8c\u6210\u7ec6\u80de\u5185\u7684\u5de5\u4f5c\u3002<\/span><\/p>\n


<\/p>\n

\u4f46\u8fd9\u4e00\u8fc7\u7a0b\u5e76\u4e0d\u603b\u662f\u7b80\u5355\u660e\u4e86\u3002<\/span><\/p>\n


<\/p>\n

DNA\u6216RNA\u7684\u5316\u5b66\u4fee\u9970\u4f1a\u5728\u4e0d\u6539\u53d8\u5b9e\u9645\u9057\u4f20\u5e8f\u5217\u7684\u60c5\u51b5\u4e0b\u6539\u53d8\u57fa\u56e0\u7684\u8868\u8fbe\u72b6\u51b5\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u79cd\u8868\u89c2\u9057\u4f20\u5b66\u4fee\u9970\u4f1a\u5f71\u54cd\u673a\u4f53\u8bb8\u591a\u751f\u7269\u5b66\u8fc7\u7a0b\u3002<\/span><\/p>\n


<\/p>\n

\u6bd4\u5982\u514d\u75ab\u7cfb\u7edf\u53cd\u5e94\u3001\u795e\u7ecf\u7ec6\u80de\u53d1\u80b2\u3001\u591a\u79cd\u4eba\u7c7b\u764c\u75c7\u751a\u81f3\u80a5\u80d6\u7b49\u3002<\/span><\/p>\n


<\/p>\n

\u5176\u4e2d\u5f88\u591a\u6539\u53d8\u5b9e\u9645\u4e0a\u662f\u901a\u8fc7\u7532\u57fa\u5316\u4f5c\u7528\u6765\u53d1\u751f\u7684\uff0c\u7532\u57fa\u5316\u4f5c\u7528\u5373\u662f\u5c06\u7532\u57fa\u5316\u57fa\u56e2\u6dfb\u52a0\u5230DNA\u6216RNA\u5206\u5b50\u4e0a\uff08\u6dfb\u52a0\u7532\u57fa\u57fa\u56e2\u7684\u86cb\u767d\u8d28\u88ab\u79f0\u4e3a\u201c\u4e66\u5199\u8005\u201d\uff0c\u800c\u79fb\u9664\u7532\u57fa\u5316\u57fa\u56e2\u7684\u86cb\u767d\u8d28\u88ab\u79f0\u4e3a\u201c\u6a61\u76ae\u64e6\u201d<\/span><\/span>\uff09\u3002<\/span><\/p>\n


<\/p>\n

\u8981\u4f7f\u5f97\u7532\u57fa\u5316\u80fd\u591f\u4ea7\u751f\u4e00\u5b9a\u7684\u751f\u7269\u5b66\u6548\u5e94\uff0c\u5c31\u5fc5\u987b\u6709\u201c\u89e3\u8bfb\u5668\u201d\u86cb\u767d\u8d28\u6765\u8bc6\u522b\u8fd9\u79cd\u53d8\u5316\u5e76\u4e0e\u4e4b\u76f8\u7ed3\u5408\u3002<\/span><\/p>\n


<\/p>\n

\u54fa\u4e73\u52a8\u7269\u673a\u4f53\u4e2d\u4fe1\u4f7fRNA\u6700\u5e38\u89c1\u7684\u4fee\u9970\u5c31\u662fN6-\u7532\u57fa\u817a\u82f7\uff08m6A\uff09\u4fee\u9970\u3002<\/span><\/p>\n


<\/p>\n

m6A\u5e7f\u6cdb\u5b58\u5728\u4e8e\u795e\u7ecf\u7cfb\u7edf\u4e2d\uff0c\u5176\u80fd\u5e2e\u52a9\u534f\u8c03\u591a\u79cd\u795e\u7ecf\u751f\u7269\u5b66\u529f\u80fd\uff0c\u5e76\u80fd\u901a\u8fc7YTH\u86cb\u767d\u5bb6\u65cf\u4e2d\u7684\u9605\u8bfb\u86cb\u767d\u6765\u53d1\u6325\u4f5c\u7528\u3002<\/span><\/p>\n


<\/p>\n

\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7<\/span>Nature<\/span><\/strong><\/span><\/em>\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u829d\u52a0\u54e5\u5927\u5b66\u3001\u6ee8\u5dde\u5927\u5b66\u548c\u4e2d\u56fd\u4e0a\u6d77\u79d1\u6280\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u8054\u5408\u7814\u7a76\u53d1\u73b0\uff1a<\/span><\/p>\n


<\/p>\n

YTH\u86cb\u767d\u5bb6\u65cf\u6210\u5458\u2014Ythdf1\u5728\u673a\u4f53\u5b66\u4e60\u548c\u8bb0\u5fc6\u5f62\u6210\u8fc7\u7a0b\u4e2d\u626e\u6f14\u91cd\u8981\u7684\u89d2\u8272\uff0cYTH\u86cb\u767d\u5bb6\u65cf\u80fd\u591f\u7279\u5f02\u6027\u5730\u8bc6\u522bm6A\u3002<\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u8005\u8868\u793a\uff0c\u5229\u7528CRISPR\/Cas9\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u6572\u9664\u5c0f\u9f20\u673a\u4f53\u4e2d\u7684Ythdf1\u540e\uff0c\u5c31\u80fd\u591f\u4fc3\u8fdbm6A\u4fee\u9970\u7684\u4fe1\u4f7fRNA\u5bf9\u673a\u4f53\u7684\u5b66\u4e60\u6d3b\u52a8\u4ea7\u751f\u53cd\u5e94\uff0c\u5e76\u76f4\u63a5\u5f15\u8d77\u795e\u7ecf\u7ec6\u80de\u523a\u6fc0\u3002<\/span><\/p>\n


<\/p>\n

\n

Nat Med\uff1a\u6bcd\u4e73\u5582\u517b\u548c\u5a74\u513f\u914d\u65b9\u5976\u7c89\u5582\u517b\u6216\u5bf9\u5a74\u513f\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u5f71\u54cd\u4e0d\u540c<\/span><\/strong><\/span><\/p>\n<\/blockquote>\n

doi\uff1a10.1038\/s41591-018-0216-2<\/span><\/p>\n


<\/p>\n

\u5a74\u513f\u914d\u65b9\u5976\u7c89\u4e0d\u4ec5\u80fd\u5728\u8425\u517b\u65b9\u9762\u6a21\u62df\u6bcd\u4e73\uff0c\u800c\u4e14\u8fd8\u80fd\u5728\u5a74\u513f\u6d88\u5316\u9053\u4e2d\u6ecb\u517b\u7c7b\u4f3c\u80a0\u9053\u83cc\u7fa4\u7684\u751f\u957f\u3002<\/span><\/p>\n


<\/p>\n

\u8bf8\u5982\u6b64\u7c7b\uff0c\u5fae\u751f\u7269\u5bf9\u4e8e\u7ef4\u6301\u673a\u4f53\u5065\u5eb7\u5fc5\u4e0d\u53ef\u5c11\uff0c\u5176\u80fd\u62b5\u5fa1\u81f4\u75c5\u83cc\u5bf9\u673a\u4f53\u7684\u5f71\u54cd\uff0c\u540c\u65f6\u8fd8\u80fd\u5f71\u54cd\u673a\u4f53\u7684\u4ee3\u8c22\u8fc7\u7a0b\u3002<\/span><\/p>\n


<\/p>\n

\u5e76\u80fd\u5e2e\u52a9\u5408\u6210\u591a\u79cd\u7ef4\u751f\u7d20\u548c\u6c28\u57fa\u9178\u6765\u4fc3\u8fdb\u5a74\u513f\u5065\u5eb7\u751f\u957f\u53d1\u80b2\u3002<\/span><\/p>\n


<\/p>\n

\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u8457\u540d\u6742\u5fd7<\/span>Nature Medicine<\/span><\/strong><\/em>\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff1a<\/span><\/p>\n


<\/p>\n

\u5f53\u5a74\u513f\u914d\u65b9\u5976\u7c89\u548c\u6bcd\u4e73\u90fd\u80fd\u4fc3\u8fdb\u5a74\u513f\u80a0\u9053\u4e2d\u76f8\u4f3c\u79cd\u7c7b\u7ec6\u83cc\u751f\u957f\u7684\u540c\u65f6\uff0c\u8fd9\u4e9b\u7ec6\u83cc\u6240\u8868\u73b0\u51fa\u7684\u201c\u5de5\u4f5c\u65b9\u5f0f\u201d\u5374\u5e76\u4e0d\u5c3d\u76f8\u540c\u3002<\/span><\/p>\n


<\/p>\n

\u76ee\u524d\u7814\u7a76\u4eba\u5458\u5e76\u4e0d\u6e05\u695a\u8fd9\u4e9b\u5dee\u5f02\u5bf9\u5a74\u513f\u673a\u4f53\u5065\u5eb7\u7684\u5f71\u54cd\u3002<\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u8005Gautam Dantas\u6559\u6388\u8bf4\u9053\uff0c\u5a74\u513f\u914d\u65b9\u5976\u7c89\u7684\u5236\u9020\u5546\u4f1a\u4e0d\u65ad\u5730\u8c03\u6574\u5976\u7c89\u539f\u6599\uff0c\u5176\u80fd\u6210\u529f\u627e\u5230\u6b63\u786e\u7684\u7ec6\u83cc\u7ec4\u5408\u3002<\/span><\/p>\n


<\/p>\n

\u4f46\u622a\u81f3\u76ee\u524d\u4e3a\u6b62\uff0c\u51e0\u4e4e\u6240\u6709\u7684\u7814\u7a76\u90fd\u91cd\u70b9\u5173\u6ce8\u7ec6\u83cc\u7684\u6210\u5206\u548c\u79cd\u7c7b\uff0c\u800c\u5bf9\u4e8e\u7ec6\u83cc\u5982\u4f55\u53d1\u6325\u4f5c\u7528\u5e76\u6ca1\u6709\u8fdb\u884c\u76f8\u5173\u7814\u7a76\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff0c\u7ec6\u83cc\u770b\u4f3c\u76f8\u540c\uff0c\u5b9e\u5219\u5176\u53d1\u6325\u7740\u4e0d\u540c\u7684\u529f\u80fd\u3002<\/span><\/p>\n


<\/p>\n

\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5bf9\u6765\u81ea60\u540d\u5a74\u513f\u80a0\u9053\u4e2d\u7ec6\u83cc\u7684\u5b8c\u6574DNA\u8fdb\u884c\u5206\u6790\u6765\u9274\u522b\u6bcf\u4e00\u4e2a\u5a74\u513f\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7684\u6210\u5458\uff0c\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u662f\u751f\u5b58\u5728\u673a\u4f53\u6d88\u5316\u9053\u4e2d\u7684\u7ec6\u83cc\u7fa4\u843d\u3002<\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u4eba\u5458\u5206\u6790\u4e86\u80a0\u9053\u83cc\u7fa4\u80fd\u591f\u5408\u6210\u4e14\u7834\u788e\u7684\u6c28\u57fa\u9178\u548c\u5176\u5b83\u751f\u7269\u6027\u5206\u6790\uff0c\u80a0\u9053\u83cc\u7fa4\u80fd\u591f\u91ca\u653e\u4ee3\u8c22\u526f\u4ea7\u7269\u6765\u5f71\u54cd\u5bbf\u4e3b\u673a\u4f53\u7684\u751f\u7406\u5b66\u529f\u80fd\u3002<\/span><\/p>\n


<\/p>\n

\u5305\u62ec\u8425\u517b\u3001\u708e\u75c7\u548c\u6d88\u5316\u7cfb\u7edf\u5065\u5eb7\u3002<\/span><\/p>\n


<\/p>\n

\n

Nat Commun\uff1a\u4ec5\u9700\u4e00\u6ef4\u8840\uff01\u4e00\u79cd\u57fa\u4e8e\u624b\u673a\u7684\u8bbe\u5907\u5c31\u53ef\u68c0\u6d4bHIV-1<\/span><\/strong><\/p>\n<\/blockquote>\n

doi\uff1a10.1038\/s41467-018-06727-8<\/span><\/p>\n


<\/p>\n

\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2HIV-1\u901a\u8fc7\u653b\u51fb\u5065\u5eb7\u7684\u514d\u75ab\u7ec6\u80de\u524a\u5f31\u4eba\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u4ece\u800c\u5bfc\u81f4\u83b7\u5f97\u6027\u514d\u75ab\u7f3a\u9677\u7efc\u5408\u5f81\uff08AIDS\uff0c\u4fd7\u79f0\u827e\u6ecb\u75c5\uff09\u3002<\/span><\/p>\n


<\/p>\n

\u5728\u7f3a\u4e4f\u57fa\u7840\u8bbe\u65bd\u548c\u8bad\u7ec3\u6709\u7d20\u7684\u533b\u7597\u4e13\u4e1a\u4eba\u5458\u7684\u53d1\u5c55\u4e2d\u56fd\u5bb6\uff0c\u63a7\u5236HIV-1\u4ecd\u7136\u662f\u4e00\u4e2a\u91cd\u5927\u7684\u5168\u7403\u5065\u5eb7\u6311\u6218\u3002 <\/span><\/p>\n


<\/p>\n

\u4f20\u7edf\u7684HIV-1\u75c5\u6bd2\u76d1\u6d4b\u65b9\u6cd5\u662f\u6bd4\u8f83\u6602\u8d35\u7684\uff0c\u9700\u8981\u4f7f\u7528\u805a\u5408\u9176\u94fe\u5f0f\u53cd\u5e94\uff08PCR\uff09\u3002<\/span><\/p>\n


<\/p>\n

\u65e9\u671f\u68c0\u6d4bHIV-1\u662f\u963b\u6b62\u75be\u75c5\u8fdb\u5c55\u548c\u4f20\u64ad\u7684\u5173\u952e\uff0c\u4f46\u662f\u5b83\u9700\u8981\u957f\u671f\u7684\u76d1\u6d4b\uff0c\u8fd9\u5bf9\u90a3\u4e9b\u5fc5\u987b\u524d\u5f80\u8bca\u6240\u6216\u533b\u9662\u7684\u5bb6\u5ead\u6765\u8bf4\u53ef\u80fd\u662f\u4e00\u4e2a\u8d1f\u62c5\u3002<\/span><\/p>\n


<\/p>\n

\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u7f8e\u56fd\u5e03\u83b1\u6839\u5987\u5973\u533b\u9662\u7684Hadi Shafiee\u535a\u58eb\u53ca\u5176\u56e2\u961f\u5229\u7528\u7eb3\u7c73\u6280\u672f\u3001\u5fae\u82af\u7247\uff08microchip\uff09\u3001\u624b\u673a\u548c\u4e09\u7ef4\u6253\u5370\u7684\u624b\u673a\u9644\u4ef6\uff0c\u5f00\u53d1\u51fa\u4e00\u79cd\u4fbf\u643a\u5f0f\u7684\u53ef\u8d1f\u62c5\u5f97\u8d77\u7684\u79fb\u52a8\u8bca\u65ad\u5de5\u5177\uff0c\u8fd9\u79cd\u5de5\u5177\u80fd\u591f\u5728\u533b\u7597\u8d44\u6e90\u6709\u9650\u7684\u5730\u533a\u7528\u4e8e\u6d4b\u8bd5\u548c\u76d1\u6d4bHIV-1\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u79cd\u5feb\u901f\u7684\u57fa\u4e8e\u624b\u673a\u7684\u8bca\u65ad\u5e73\u53f0\u4ee3\u8868\u7740\u4e00\u79cd\u8bca\u65ad\u6025\u6027\u75c5\u6bd2\u611f\u67d3\u7684\u65b0\u65b9\u6cd5\uff0c\u4ece\u800c\u53ef\u80fd\u964d\u4f4e\u75c5\u6bd2\u4f20\u64ad\u98ce\u9669\u3002<\/span><\/p>\n


<\/p>\n

\u6b64\u5916\uff0c\u5b83\u4e5f\u53ef\u80fd\u7528\u4e8e\u68c0\u6d4b\u65e9\u671f\u7684\u6cbb\u7597\u5931\u8d25\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u8fd1\u671f\u53d1\u8868\u5728<\/span>Nature Communications<\/span><\/em><\/strong>\u671f\u520a\u4e0a\u3002<\/span><\/p>\n


<\/p>\n

\n

Immunity\uff1a\u7a81\u7834\uff01\u65b0\u578b\u6297\u4f53\u6709\u671b\u6cbb\u7597\u591a\u79cd\u7c7b\u578b\u764c\u75c7<\/span><\/strong><\/p>\n<\/blockquote>\n

doi\uff1a10.1016\/j.immuni.2018.09.014<\/span><\/p>\n


<\/p>\n

\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7<\/span>Immunity<\/span><\/em><\/strong>\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u5357\u5b89\u666e\u6566\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u6297\u4f53\uff0c\u5176\u6216\u80fd\u5e2e\u52a9\u9610\u660e\u764c\u75c7\u62b5\u5fa1\u673a\u4f53\u514d\u75ab\u7cfb\u7edf\u7684\u5965\u79d8\u3002<\/span><\/p>\n


<\/p>\n

\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5bf9\u6297\u4f53\u8fdb\u884c\u5de5\u7a0b\u5316\u6539\u9020\u4f7f\u5176\u80fd\u591f\u9776\u5411\u4f5c\u7528\u514d\u75ab\u53d7\u4f534-1BB\uff0c\u8be5\u53d7\u4f53\u80fd\u591f\u6fc0\u6d3b\u6740\u4f24\u6027T\u7ec6\u80de\u6765\u5bfb\u627e\u5e76\u7834\u574f\u764c\u7ec6\u80de\u3002<\/span><\/p>\n


<\/p>\n

4-1BB\u662f\u4e00\u79cd\u514d\u75ab\u7597\u6cd5\u9776\u70b9\uff0c\u5176\u4e3b\u8981\u5b58\u5728\u4e8e\u80bf\u7624\u4e2d\u8c03\u8282\u6027T\u7ec6\u80de\u4e0a\u3002<\/span><\/p>\n


<\/p>\n

\u800c\u8c03\u8282\u6027T\u7ec6\u80de\u80fd\u591f\u5173\u95ed\u6740\u4f24\u6027T\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u540c\u65f6\u6740\u4f24\u6027T\u7ec6\u80de\u4e5f\u80fd\u8868\u8fbe4-1BB\uff0c\u4f46\u8868\u8fbe\u7a0b\u5ea6\u8f83\u4f4e\u3002<\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u4eba\u5458\u5728\u4e34\u5e8a\u524d\u80bf\u7624\u6a21\u578b\u4e2d\u8bbe\u5b9a\u4e86\u4e00\u79cd4-1BB\u6297\u4f53\uff0c\u5176\u80fd\u591f\u5254\u9664\u8c03\u8282\u6027T\u7ec6\u80de\u4ece\u800c\u4fc3\u8fdb\u5bfc\u81f4\u80bf\u7624\u6d88\u9000\u3002<\/span><\/p>\n


<\/p>\n

\u7136\u800c\uff0c\u56e0\u4e3a\u8fd9\u79cd\u6297\u4f53\u975e\u5e38\u64c5\u957f\u5254\u9664\u8c03\u8282\u6027T\u7ec6\u80de\u800c\u5e76\u4e0d\u64c5\u957f\u523a\u6fc0\u6740\u4f24\u6027T\u7ec6\u80de\u3002<\/span><\/p>\n


<\/p>\n

\u56e0\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u4f3c\u4e4e\u5e76\u4e0d\u53ef\u80fd\u5229\u7528\u8fd9\u7c7b\u89c4\u5219\u7684\u6297\u4f53\u6765\u8c03\u8282\u75be\u75c5\u7684\u6cbb\u7597\u624b\u6bb5\u3002<\/span><\/p>\n


<\/p>\n

\n

\uff1a\u91cd\u78c5\uff01\u4e2d\u56fd\u79d1\u5b66\u5bb6\u5f00\u53d1\u51fa\u6709\u671b\u6839\u6cbb\u6210\u4eba\u6076\u6027\u8111\u7624\u7684\u65b0\u7597\u6cd5\uff01<\/span><\/strong><\/p>\n<\/blockquote>\n

doi\uff1a10.1016\/j.cell.2018.09.038<\/span><\/p>\n


<\/p>\n

sGBM\uff08secondary glioblastoma\uff0c\u7ee7\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff09\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u6210\u5e74\u4eba\u8111\u7624\u3002<\/span><\/p>\n


<\/p>\n

\u6bcf\u5e74\u7684\u8be5\u75c5\u7684\u53d1\u751f\u7387\u4e3a\u767e\u4e07\u5206\u4e4b\u4e8c\u81f3\u767e\u4e07\u5206\u4e4b\u4e94\uff0c\u6bd4\u5982\u4ee5\u9999\u6e2f\u7684750\u4e07\u4eba\u53e3\u4e3a\u53c2\u7167\u7684\u8bdd\u3002<\/span><\/p>\n


<\/p>\n

\u90a3\u4e48\uff0c\u6bcf\u5e74\u5c06\u4f1a\u6709\u8d85\u8fc715\u4eba\u88ab\u8bca\u65ad\u4e3a\u7ee7\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u79cd\u80bf\u7624\u8d77\u521d\u662f\u4ece\u5305\u56f4\u810a\u67f1\u548c\u5927\u8111\u7684\u795e\u7ecf\u7ec6\u80de\u5468\u56f4\u4f4e\u7ea7\u522b\u7684\u795e\u7ecf\u80f6\u8d28\u7624\uff08LGG\uff09\u5f00\u59cb\u53d1\u751f\u7684\uff0c\u60a3\u8005\u76845\u5e74\u751f\u5b58\u7387\u4f4e\u4e8e10%\u3002<\/span><\/p>\n


<\/p>\n

\u76ee\u524d\u7814\u7a76\u4eba\u5458\u5229\u7528\u540d\u4e3a\u66ff\u83ab\u5511\u80fa\uff08TMZ\uff09\u7684\u5316\u7597\u836f\u7269\u6765\u6cbb\u7597\u7ee7\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff0c\u800c\u8be5\u7597\u6cd5\u9996\u5148\u5728\u6b27\u6d32\u88ab\u5f00\u53d1\u3002<\/span><\/p>\n


<\/p>\n

\u572821\u4e16\u7eaa\u521d\u671f\u5f00\u59cb\u88ab\u5e7f\u6cdb\u4f7f\u7528\uff0c\u836f\u7269\u66ff\u83ab\u5511\u80fa\u4f1a\u8bf1\u53d1\u80bf\u7624\u7ec6\u80de\u51fa\u73b0\u975e\u7279\u5f02\u6027\u7684DNA\u635f\u4f24\uff0c\u4ece\u800c\u6291\u5236\u80bf\u7624\u518d\u751f\u548c\u6269\u6563\u3002<\/span><\/p>\n


<\/p>\n

\u7136\u800c\u5386\u53f2\u548c\u60a3\u8005\u6570\u636e\u663e\u793a\uff0c\u63a5\u53d7\u66ff\u83ab\u5511\u80fa\u6cbb\u7597\u7684\u7ee7\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u51e0\u4e4e\u603b\u662f\u4f1a\u51fa\u73b0\u75c5\u60c5\u590d\u53d1\u7684\u72b6\u51b5\u3002<\/span><\/p>\n


<\/p>\n

\u800c\u4e14\u80bf\u7624\u6240\u8868\u73b0\u51fa\u7684\u7a81\u53d8\u4f1a\u8ba9\u80bf\u7624\u8eb2\u907f\u7b2c\u4e8c\u8f6e\u66ff\u83ab\u5511\u80fa\u7684\u6cbb\u7597\uff0c\u5e76\u5bf9\u5316\u7597\u4ea7\u751f\u8010\u53d7\u6027\uff0c\u56e0\u6b64\u7814\u7a76\u4eba\u5458\u5c31\u9700\u8981\u5bfb\u627e\u66f4\u597d\u7684\u6cbb\u7597\u624b\u6bb5\u3002<\/span><\/p>\n


<\/p>\n

\n

Front Neurosci\uff1a\u5750\u5b9e\uff01\u559d\u5496\u5561\u771f\u7684\u80fd\u591f\u964d\u4f4e\u963f\u5c14\u5179\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75be\u75c5\u7684\u60a3\u75c5\u98ce\u9669\uff01<\/span><\/strong><\/p>\n<\/blockquote>\n

doi\uff1a10.3389\/fnins.2018.00735<\/span><\/p>\n


<\/p>\n

\u6bcf\u5e74\u5168\u7403\u5927\u7ea6\u4f1a\u6d88\u8d395000\u4ebf\u676f\u5496\u5561\u3002<\/span><\/p>\n


<\/p>\n

\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7<\/span>Frontiers in Neuroscience <\/span><\/em><\/span><\/strong>\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u52a0\u62ff\u5927Krembil\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff1a<\/span><\/p>\n


<\/p>\n

\u559d\u5496\u5561\u6216\u80fd\u5e2e\u52a9\u964d\u4f4e\u4e2a\u4f53\u60a3\u963f\u5c14\u5179\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75be\u75c5\u7684\u98ce\u9669\u3002<\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u8005Donald Weaver\u8bf4\u9053\uff0c\u6444\u5165\u5496\u5561\u4f3c\u4e4e\u5e76\u4e0d\u4f1a\u8ba9\u6211\u4eec\u60a3\u4e0a\u963f\u5c14\u5179\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75be\u75c5\uff0c\u4f46\u6211\u4eec\u60f3\u77e5\u9053\u5176\u4e2d\u7684\u539f\u56e0\u662f\u4ec0\u4e48\u3002<\/span><\/p>\n


<\/p>\n

\u662f\u5426\u662f\u56e0\u4e3a\u5496\u5561\u4e2d\u7684\u67d0\u4e9b\u5316\u5408\u7269\u53d1\u6325\u4e86\u5173\u952e\u4f5c\u7528\uff0c\u4ece\u800c\u80fd\u5e2e\u52a9\u51cf\u7f13\u5e74\u9f84\u76f8\u5173\u7684\u673a\u4f53\u8ba4\u77e5\u529b\u4e0b\u964d\u3002<\/span><\/p>\n


<\/p>\n

\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5bf9\u4e09\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u5496\u5561\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u5206\u522b\u662f\u6d45\u70d8\u7119\u5496\u5561\uff08light roast\uff09\u3001\u7126\u7092\u5496\u5561\uff08dark roast\uff09\u548c\u65e0\u5496\u5561\u56e0\u7684\u7126\u7092\u5496\u5561\uff08decaffeinated dark roast\uff09\u3002<\/span><\/p>\n


<\/p>\n

\n

Nature\uff1a\u91cd\u5927\u53d1\u73b0\uff01\u80a0\u9053\u83cc\u7fa4\u6216\u80fd\u63a7\u5236\u673a\u4f53\u7684\u8fd0\u52a8\u65b9\u5f0f\uff01<\/span><\/strong><\/p>\n<\/blockquote>\n

doi\uff1a10.1038\/s41586-018-0634-9<\/span><\/p>\n


<\/p>\n

\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7<\/span>Nature<\/span><\/em><\/strong>\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u52a0\u5dde\u7406\u5de5\u5b66\u9662\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u5bf9\u201c\u8ddf\u7740\u76f4\u89c9\u8d70\u201d\u7684\u542b\u4e49\u8fdb\u884c\u4e86\u65b0\u7684\u8be0\u91ca\u3002<\/span><\/p>\n


<\/p>\n

\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u8005\u53d1\u73b0\uff0c\u80a0\u9053\u83cc\u7fa4\u80fd\u591f\u63a7\u5236\u679c\u8747\u7684\u8fd0\u52a8\uff0c\u540c\u65f6\u4ed6\u4eec\u8fd8\u9274\u522b\u51fa\u4e86\u53c2\u4e0e\u6574\u4e2a\u8fc7\u7a0b\u7684\u7279\u6b8a\u795e\u7ecf\u5143\u3002<\/span><\/p>\n


<\/p>\n

\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u6216\u80fd\u9610\u660e\u673a\u4f53\u80a0\u9053\u548c\u5927\u8111\u4e4b\u95f4\u7684\u5173\u8054\uff0c\u5c24\u5176\u662f\u80fd\u591f\u9610\u660e\u80a0\u9053\u83cc\u7fa4\u5f71\u54cd\u673a\u4f53\u884c\u4e3a\uff08\u5305\u62ec\u8fd0\u52a8\uff09\u7684\u5206\u5b50\u673a\u5236\u3002<\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u8005Sarkis K. Mazmanian\u6559\u6388\u8868\u793a\uff0c\u6211\u4eec\u89c2\u5bdf\u5230\u4e0d\u643a\u5e26\u7ec6\u83cc\u7684\u65e0\u83cc\u679c\u8747\u5e38\u5e38\u4f1a\u5f02\u5e38\u6d3b\u8dc3\u3002<\/span><\/p>\n


<\/p>\n

\u76f8\u6bd4\u643a\u5e26\u6b63\u5e38\u6c34\u5e73\u5fae\u751f\u7269\u7684\u679c\u8747\u800c\u8a00\uff0c\u8fd9\u4e9b\u679c\u8747\u4f1a\u8d70\u5f97\u66f4\u5feb\uff0c\u66f4\u8fdc\uff0c\u800c\u4e14\u4f11\u606f\u7684\u65f6\u95f4\u4e5f\u66f4\u77ed\u3002<\/span><\/p>\n


<\/p>\n

\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u8c03\u67e5\u4e86\u80a0\u9053\u83cc\u7fa4\u5f71\u54cd\u679c\u8747\u884c\u4e3a\u7684\u901a\u8def\u3002<\/span><\/p>\n


<\/p>\n

\u8fd0\u52a8\u5bf9\u4e8e\u673a\u4f53\u7684\u4e00\u7cfb\u5217\u6d3b\u52a8\u90fd\u975e\u5e38\u91cd\u8981\uff0c\u6bd4\u5982\u4ea4\u914d\u3001\u5bfb\u627e\u98df\u7269\u7b49\u3002<\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u80a0\u9053\u83cc\u7fa4\u6216\u8bb8\u5bf9\u4e8e\u52a8\u7269\u673a\u4f53\u7684\u57fa\u7840\u884c\u4e3a\u975e\u5e38\u91cd\u8981\u3002<\/span><\/p>\n


<\/p>\n

\u679c\u8747\u643a\u5e26\u77405-20\u79cd\u4e0d\u540c\u7684\u83cc\u7fa4\uff0c\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5229\u7528\u6bcf\u4e00\u79cd\u7ec6\u83cc\u5904\u7406\u65e0\u83cc\u679c\u8747\u3002<\/span><\/p>\n


<\/p>\n

\u7ed3\u679c\u53d1\u73b0\uff0c\u5f53\u679c\u8747\u63a5\u89e6\u77ed\u4e73\u6746\u83cc\u65f6\uff0c\u5176\u79fb\u52a8\u901f\u5ea6\u5c31\u4f1a\u964d\u4f4e\u81f3\u6b63\u5e38\u6c34\u5e73\u3002<\/span><\/p>\n


<\/p>\n

\u56e0\u6b64\u77ed\u4e73\u6746\u83cc\u6216\u8bb8\u5c31\u662f\u80fd\u591f\u6062\u590d\u65e0\u83cc\u679c\u8747\u6b63\u5e38\u884c\u4e3a\u7684\u5176\u4e2d\u4e00\u79cd\u5173\u952e\u7ec6\u83cc\u3002<\/span><\/p>\n


<\/p>\n

\u540c\u65f6\u7814\u7a76\u8005\u8fd8\u53d1\u73b0\uff0c\u4e00\u79cd\u540d\u4e3a\u6728\u7cd6\u5f02\u6784\u9176\uff08xylose isomerase\uff0cXI\uff09\u7684\u5206\u5b50\u5bf9\u4e8e\u8be5\u8fc7\u7a0b\u975e\u5e38\u91cd\u8981\u3002<\/span><\/p>\n


<\/p>\n

\u56e0\u4e3a\u77ed\u4e73\u6746\u83cc\u4e2d\u5b58\u5728\u6728\u7cd6\u5f02\u6784\u9176\uff0c\u4e14\u8be5\u9176\u80fd\u591f\u5206\u89e3\u7cd6\u7c7b\uff0c\u5229\u7528\u6728\u7cd6\u5f02\u6784\u9176\u6765\u5904\u7406\u679c\u8747\u5c31\u8db3\u4ee5\u51cf\u7f13\u5176\u8fd0\u52a8\u901f\u5ea6\u3002<\/span><\/p>\n


<\/p>\n

\n

Science\uff1a\u8457\u540d\u534e\u4eba\u5b66\u8005\u5e84\u5c0f\u5a01\u518d\u53d1\u529b\u4f5c\uff0c\u6784\u5efa\u51fa\u4e0b\u4e18\u8111\u89c6\u524d\u533a\u7684\u7ec6\u80de\u7a7a\u95f4\u56fe\u8c31<\/span><\/strong><\/span><\/p>\n<\/blockquote>\n

doi\uff1a10.1126\/science.aau5324<\/span><\/p>\n


<\/p>\n

\u79d1\u5b66\u5bb6\u4eec\u65e9\u5c31\u610f\u8bc6\u5230\u4e3a\u4e86\u7814\u7a76\u5927\u8111\uff0c\u5c31\u5fc5\u987b\u4e86\u89e3\u7ec4\u6210\u5927\u8111\u7684\u7ec6\u80de\u3002<\/span><\/p>\n


<\/p>\n

\u5982\u679c\u83b7\u53d6\u4e00\u5757\u5927\u8111\u7ec4\u7ec7\uff0c\u7814\u7a76\u7ec4\u7ec7\u4e2d\u7ec6\u80de\u8868\u8fbe\u7684\u57fa\u56e0\uff0c\u8fd9\u53ef\u53d1\u73b0\u5927\u8111\u7ec4\u7ec7\u4e2d\u5b58\u5728\u591a\u5c11\u79cd\u7ec6\u80de\u7c7b\u578b\uff0c\u4f46\u662f\u8fd9\u4ecd\u7136\u4f1a\u7559\u4e0b\u4e00\u5927\u5927\u95ee\u9898\uff1a<\/span><\/p>\n


<\/p>\n

\u4e3a\u4e86\u7814\u7a76\u8fd9\u4e9b\u7ec6\u80de\u8868\u8fbe\u7684\u57fa\u56e0\uff0c\u9700\u8981\u5c06\u5b83\u4eec\u4ece\u5927\u8111\u7ec4\u7ec7\u4e2d\u8131\u79bb\u4e0b\u6765\uff0c\u7136\u800c\uff0c\u8fd9\u4f1a\u4e22\u5931\u5b9d\u8d35\u7684\u4fe1\u606f—\u5b83\u4eec\u662f\u5982\u4f55\u5728\u7ec4\u7ec7\u4e2d\u7ec4\u88c5\u5728\u4e00\u8d77\u7684\u3002<\/span><\/p>\n


<\/p>\n

\u56e0\u6b64\uff0c\u5982\u679c\u4eba\u4eec\u60f3\u8981\u771f\u6b63\u5730\u7406\u89e3\u5927\u8111\uff0c\u5c31\u9700\u8981\u4e86\u89e3\u5927\u8111\u4e2d\u7684\u7ec6\u80de\u6240\u5728\u7684\u7a7a\u95f4\u73af\u5883\u3002<\/span><\/p>\n


<\/p>\n

\u4e0d\u540c\u4e8e\u809d\u810f\u6216\u5176\u4ed6\u5668\u5b98\u7684\u662f\uff0c\u5927\u8111\u7684\u4e0d\u540c\u5bfb\u5e38\u4e4b\u5904\u5728\u4e8e\u5927\u8111\u4e2d\u7684\u7ec6\u80de\u4ee5\u4e00\u79cd\u5bf9\u79f0\u7684\u5f62\u5f0f\u8fdb\u884c\u7ec4\u88c5\u3002<\/span><\/p>\n


<\/p>\n

\u56e0\u6b64\u5728\u7814\u7a76\u4e00\u5757\u5927\u8111\u7ec4\u7ec7\u65f6\uff0c\u5e94\u5f53\u4e0d\u4ec5\u80fd\u591f\u89c2\u5bdf\u8fd9\u79cd\u7ec4\u7ec7\u4e2d\u6709\u54ea\u4e9b\u7ec6\u80de\u7c7b\u578b\uff0c\u800c\u4e14\u8fd8\u80fd\u591f\u89c2\u5bdf\u5b83\u4eec\u5728\u54ea\u91cc\uff0c\u5b83\u4eec\u5468\u56f4\u6709\u54ea\u4e9b\u7c7b\u578b\u7684\u7ec6\u80de\u3002<\/span><\/p>\n


<\/p>\n

\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u901a\u8fc7\u4f7f\u7528MERFISH\uff0cZhuang\u4e0e\u54c8\u4f5b\u5927\u5b66\u7684Catherine Dulac\u6559\u6388\u5408\u4f5c\uff0c\u7740\u624b\u89e3\u51b3\u90a3\u4e9b\u957f\u671f\u56f0\u6270\u7740\u8bd5\u56fe\u7406\u89e3\u5927\u8111\u8fd0\u4f5c\u65b9\u5f0f\u7684\u79d1\u5b66\u5bb6\u4eec\u7684\u95ee\u9898\u3002<\/span><\/p>\n


<\/p>\n

\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e7411\u67081\u65e5\u5728\u7ebf\u53d1\u8868\u5728<\/span>Science<\/span><\/em><\/strong>\u671f\u520a\u4e0a\u3002<\/span><\/p>\n


<\/p>\n

\n

\uff1a\u6784\u5efa\u51fa\u4eba\u7c7b\u514d\u75ab\u7ec6\u80de\u56fe\u8c31\uff0c\u53ef\u786e\u5b9a\u9057\u4f20\u53d8\u5f02\u5bf9\u57fa\u56e0\u8868\u8fbe\u7684\u5f71\u54cd<\/span><\/strong><\/p>\n<\/blockquote>\n

doi\uff1a10.1016\/j.cell.2018.10.022<\/span><\/p>\n


<\/p>\n

\u6bd4\u8f83\u4efb\u4f55\u4e24\u4e2a\u4eba\u7684DNA\uff0c\u4f60\u4f1a\u53d1\u73b0\u4ed6\u4eec\u7684\u9057\u4f20\u5bc6\u7801\u4e2d\u7684\u6570\u767e\u4e07\u4e2a\u4f4d\u70b9\u5b58\u5728\u7740\u4e0d\u540c\u3002<\/span><\/p>\n


<\/p>\n

\u5982\u4eca\uff0c\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u62c9\u970d\u4e9a\u514d\u75ab\u5b66\u7814\u7a76\u6240\uff08LJI\uff09\u7684\u7814\u7a76\u4eba\u5458\u5206\u4eab\u4e86\u5927\u91cf\u6570\u636e\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u4e9b\u6570\u636e\u5bf9\u4e8e\u7834\u8bd1\u8fd9\u79cd\u81ea\u7136\u9057\u4f20\u53d8\u5f02\u5982\u4f55\u5f71\u54cd\u514d\u75ab\u7cfb\u7edf\u4fdd\u62a4\u6211\u4eec\u5065\u5eb7\u7684\u80fd\u529b\u81f3\u5173\u91cd\u8981\u3002<\/span><\/p>\n


<\/p>\n

\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e7411\u670815\u65e5\u5728\u7ebf\u53d1\u8868\u5728<\/span><\/span><\/em><\/strong>\u671f\u520a\u4e0a\u3002<\/span><\/p>\n


<\/p>\n

\u56db\u5e74\u591a\u6765\uff0c\u5728Pandurangan Vijayanand\u535a\u58eb\u7684\u9886\u5bfc\u4e0b\uff0c\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u4e00\u76f4\u5728\u8fdb\u884c\u5927\u89c4\u6a21\u7684\u514d\u75ab\u5206\u6790\u5de5\u4f5c\u3002<\/span><\/p>\n


<\/p>\n

\u5e76\u8be6\u7ec6\u8bf4\u660e\u4e86DNA\u5e8f\u5217\u4e2d\u7684\u53d8\u5f02\u5982\u4f55\u5f71\u54cd\u4e0d\u540c\u7c7b\u578b\u514d\u75ab\u7ec6\u80de\u4e2d\u7684\u57fa\u56e0\u6d3b\u6027\u3002<\/span><\/p>\n


<\/p>\n

\u4ed6\u4eec\u6b63\u5728\u901a\u8fc7\u4e00\u4e2a\u65b0\u7684\u6570\u636e\u5e93DICE\uff08Database of Immune Expression\uff0c Expression of quantitative trait loci and Epigenomics\uff0c \u5373\u514d\u75ab\u7ec6\u80de\u8868\u8fbe\u3001\u6570\u91cf\u6027\u72b6\u5ea7\u4f4d\u8868\u8fbe\u548c\u8868\u89c2\u57fa\u56e0\u7ec4\u5b66\u6570\u636e\u5e93\uff09\u6765\u5206\u4eab\u4ed6\u4eec\u7684\u53d1\u73b0\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u4f7f\u5f97\u4e16\u754c\u5404\u5730\u7684\u79d1\u5b66\u5bb6\u4eec\u8f7b\u677e\u5730\u63a2\u7a76\u8fd9\u4e9b\u6570\u636e\uff0c\u8fd9\u662f\u56e0\u4e3a\u5b83\u4eec\u4e0e\u57fa\u56e0\u3001\u7ec6\u80de\u7c7b\u578b\u6216\u8005\u75be\u75c5\u5b58\u5728\u5173\u8054\u3002<\/span><\/p>\n


<\/p>\n

\u4e3a\u4e86\u786e\u5b9a\u9057\u4f20\u53d8\u5f02\u5bf9\u514d\u75ab\u7cfb\u7edf\u7684\u5f71\u54cd\uff0cVijayanand\u53ca\u5176\u540c\u4e8b\u4eec\u4ea7\u751f\u4e8615\u79cd\u7c7b\u578b\u514d\u75ab\u7ec6\u80de\u7684\u57fa\u56e0\u6d3b\u6027\u8c31\u3002<\/span><\/p>\n


<\/p>\n

\u5176\u4e2d\u8fd915\u79cd\u7c7b\u578b\u7684\u514d\u75ab\u7ec6\u80de\u53d1\u8868\u7740\u572891\u540d\u5065\u5eb7\u4f9b\u8005\u4e2d\u6bcf\u4e2a\u4eba\u7684\u8840\u6db2\u4e2d\u53d1\u73b0\u7684\u6700\u4e3a\u4e30\u5bcc\u7684\u7ec6\u80de\u7c7b\u578b\u3002<\/span><\/p>\n


<\/p>\n

\u4ed6\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u63ed\u793a\u4e86\u9057\u4f20\u53d8\u5f02\u5bf9\u514d\u75ab\u7cfb\u7edf\u4e2d\u57fa\u56e0\u6d3b\u6027\u7684\u6df1\u8fdc\u5f71\u54cd\u3002\u5bf912000\u591a\u4e2a\u57fa\u56e0—\u5927\u7ea6\u5360\u8fd9\u4e9b\u7ec6\u80de\u4e2d\u6240\u6709\u6d3b\u6027\u57fa\u56e0\u768460\uff05—\u800c\u8a00\uff0c\u5929\u7136\u5b58\u5728\u7684\u9057\u4f20\u53d8\u5f02\u4e0e\u67d0\u4e9b\u7ec6\u80de\u7c7b\u578b\u4e2d\u57fa\u56e0\u6d3b\u6027\u7684\u663e\u7740\u5dee\u5f02\u76f8\u5173\u3002<\/span><\/p>\n


<\/p>\n

Vijayanand\u8bf4\uff0c\u201c\u6211\u4eec\u89c2\u5bdf\u5230\u7684\u6548\u5e94\u5927\u5c0f\u662f\u4ee4\u4eba\u5403\u60ca\u7684\u3002\u8fd9\u4e0d\u662f\u4e00\u4e9b\u5fae<\/span>\u5c0f\u53d8\u5316\u3002\u201d<\/span><\/p>\n

\u8f6c\u81ea  \u751f\u7269\u8c37<\/p>\n

\"11\u6708\u5fc5\u770b\u7684\u91cd\u78c5\u7ea7\u7814\u7a76Top10\"<\/section>\n
\n


<\/p>\n

\u66f4\u591a\u7cbe\u5f69\u5185\u5bb9\uff1a\"11\u6708\u5fc5\u770b\u7684\u91cd\u78c5\u7ea7\u7814\u7a76Top10\"<\/span><\/strong><\/p>\n