{"id":68208,"date":"2018-11-28T01:00:00","date_gmt":"2018-12-07T04:22:20","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/202a2dd7db\/"},"modified":"2018-12-07T12:22:21","modified_gmt":"2018-12-07T04:22:21","slug":"202a2dd7db","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/68208\/","title":{"rendered":"CDE\u53d1\u5e03\u300a\u5bf9\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u6dcb\u5df4\u7ec6\u80de\u6cbb\u7597\u6dcb\u5df4\u9020\u8840\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u8003\u8651\u300b"},"content":{"rendered":"
\n

\"CDE\u53d1\u5e03\u300a\u5bf9\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u6dcb\u5df4\u7ec6\u80de\u6cbb\u7597\u6dcb\u5df4\u9020\u8840\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u8003\u8651\u300b\"<\/p>\n

\"CDE\u53d1\u5e03\u300a\u5bf9\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u6dcb\u5df4\u7ec6\u80de\u6cbb\u7597\u6dcb\u5df4\u9020\u8840\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u8003\u8651\u300b\"
<\/p>\n


<\/p>\n

\u4e00\u3001\u80cc\u666f\u7b80\u4ecb<\/strong>
       \u968f\u7740\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u53d1\u5c55\uff0c\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u5728\u6076\u6027\u80bf\u7624\u4e2d\u7684\u6cbb\u7597\u6f5c\u529b\u5f97\u5230\u8d8a\u6765\u8d8a\u591a\u7684\u5173\u6ce8\u3002\u5176\u4e2d\uff0c\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u6dcb\u5df4\u7ec6\u80de\uff08CAR-T\uff09\u5728\u6dcb\u5df4\u9020\u8840\u7cfb\u7edf\u6076\u6027\u80bf\u7624\uff0c\u5982B\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3001B\u7ec6\u80de\u6dcb\u5df4\u7624\u548c\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7b49\u7684\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u975e\u5e38\u6709\u5438\u5f15\u529b\u7684\u6cbb\u7597\u524d\u666f\u3002\u7531\u4e8eCAR-T\u7ec6\u80de\u6cbb\u7597\u5c5e\u4e8e\u975e\u5e38\u524d\u6cbf\u7684\u4ea7\u54c1\uff0c\u56fd\u5185\u3001\u56fd\u5916\u76d1\u7ba1\u673a\u6784\u5bf9\u4ea7\u54c1\u7684\u7279\u6027\u3001\u5c24\u5176\u662f\u4e34\u5e8a\u7597\u6548\u548c\u5b89\u5168\u6027\u98ce\u9669\u7684\u7279\u70b9\u548c\u8bc4\u4ef7\u8fd8\u5728\u4e0d\u65ad\u79ef\u7d2f\u7ecf\u9a8c\uff0c\u5c1a\u672a\u5236\u5b9a\u51fa\u6210\u719f\u7684\u6280\u672f\u6807\u51c6\u3002<\/span>
       \u76ee\u524d\uff0c\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u6536\u5230\u591a\u5bb6\u4f01\u4e1a\u6216\u7814\u7a76\u673a\u6784\u9012\u4ea4\u7684CAR-T\u7ec6\u80de\u6cbb\u7597\u6dcb\u5df4\u9020\u8840\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u3002CDE\u5728\u5ba1\u8bc4\u8fc7\u7a0b\u4e2d\u53d1\u73b0\uff0c\u7533\u8bf7\u4eba\u9012\u4ea4\u7684\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u5728\u53d7\u8bd5\u8005\u7b5b\u9009\u3001\u7597\u6548\u9884\u540e\u6307\u6807\u3001\u98ce\u9669\u63a7\u5236\u7b49\u65b9\u9762\u5b58\u5728\u5f88\u591a\u5171\u6027\u95ee\u9898\uff0c\u53ef\u80fd\u5f71\u54cd\u53d7\u8bd5\u8005\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u5224\u65ad\u3002<\/span>
       \u4e3a\u4e86\u8fdb\u4e00\u6b65\u4fc3\u8fdb\u6211\u56fdCAR-T\u7c7b\u7ec6\u80de\u4ea7\u54c1\u6cbb\u7597\u6dcb\u5df4\u9020\u8840\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u89c4\u8303\u5f00\u5c55\uff0c\u4fdd\u969c\u60a3\u8005\u5728\u4e34\u5e8a\u8bd5\u9a8c\u671f\u95f4\u7684\u6743\u76ca\u548c\u5b89\u5168\u6027\uff0c\u6211\u4e2d\u5fc3\u5bf9\u4e0a\u8ff0\u5171\u6027\u95ee\u9898\u8fdb\u884c\u4e86\u68b3\u7406\u5e76\u4e0e\u76f8\u5173\u9886\u57df\u7684\u4e34\u5e8a\u4e13\u5bb6\u8fdb\u884c\u4e86\u63a2\u8ba8\uff0c\u65e8\u5728\u4e0e\u4e13\u5bb6\u548c\u4e1a\u754c\u5728\u79d1\u5b66\u8bbe\u8ba1\u548c\u5f00\u5c55CAR-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u9762\u8fbe\u6210\u5171\u8bc6\uff0c\u672c\u6587\u4e2d\u7684\u76f8\u5173\u5185\u5bb9\u53ca\u8003\u8651\u8981\u70b9\u53ef\u80fd\u968f\u7740CAR-T\u7c7b\u7ec6\u80de\u6cbb\u7597\u4e34\u5e8a\u7814\u7a76\u548c\u76f8\u5173\u75be\u75c5\u4e34\u5e8a\u5b9e\u8df5\u7ecf\u9a8c\u7684\u79ef\u7d2f\u800c\u8fdb\u4e00\u6b65\u5b8c\u5584\u3002\u540c\u65f6\uff0c\u4e5f\u9f13\u52b1\u7533\u529e\u65b9\u6216\u7814\u7a76\u8005\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u7ed3\u5408\u5177\u4f53\u4ea7\u54c1\u7684\u79cd\u7c7b\u7279\u5f81\u548c\u7814\u7a76\u8fdb\u5c55\uff0c\u6839\u636e\u5b9e\u9645\u60c5\u51b5\u5236\u5b9a\u66f4\u6709\u5229\u4e8e\u63a2\u7d22\u4ea7\u54c1\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u3002<\/span>
\u4e8c\u3001\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u4e2d\u7684\u8003\u8651<\/strong>

       \u5728\u4ee5\u6025\u6027B\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u4e3a\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u8003\u8651\u5230\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u4e0e\u6210\u4eba\u60a3\u8005\u5728\u81f4\u75c5\u539f\u56e0\u3001\u514d\u75ab\u8868\u578b\u3001\u67d3\u8272\u4f53\u5f02\u5e38\u3001\u5316\u7597\u65b9\u6848\u3001\u4e34\u5e8a\u9884\u540e\u7b49\u65b9\u9762\u5b58\u5728\u8f83\u5927\u5dee\u5f02\uff0c\u800c\u4e0a\u8ff0\u5dee\u5f02\u53c8\u53ef\u80fd\u5bf9\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u5e72\u9884\u624b\u6bb5\uff08\u7ec6\u80de\u6cbb\u7597\uff09\u7684\u53cd\u5e94\u5e26\u6765\u5dee\u5f02\uff0c\u56e0\u6b64\uff0c\u5efa\u8bae\u4e0d\u8981\u5728\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u540c\u65f6\u62db\u52df\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u60a3\u8005\u4e0e\u6210\u5e74\u60a3\u8005\uff0c\u7533\u8bf7\u4eba\u53ef\u57fa\u4e8e\u4e0d\u540c\u5e74\u9f84\u60a3\u8005\u7684\u4e34\u5e8a\u53d1\u75c5\u548c\u6cbb\u7597\u9884\u540e\u7b49\u65b9\u9762\u7684\u7279\u70b9\uff0c\u8bbe\u8ba1\u79d1\u5b66\u5408\u7406\u7684\u8bd5\u9a8c\u65b9\u6848\uff0c\u5728\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u60a3\u8005\u4e0e\u6210\u4eba\u60a3\u8005\u4e2d\u5206\u522b\u5f00\u5c55\u7814\u7a76\u3002<\/span>


       \u6210\u4ebaALL\u60a3\u8005\u63a5\u53d7\u7cfb\u7edf\u6cbb\u7597\u540e\uff0c\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u7387\u53ef\u8fbe70%\uff5e90%\uff0c3\uff5e5\u5e74\u65e0\u75c5\u751f\u5b58\uff08DFS\uff09\u7387\u8fbe30%\uff5e60%\uff1b\u513f\u7ae5ALL\u60a3\u8005\u7684\u957f\u671f\u65e0\u4e8b\u4ef6\u751f\u5b58\u7387\u53ef\u8fbe70%\uff5e80%\u3002\u56e0\u6b64\uff0c\u4e3a\u4fdd\u62a4\u53d7\u8bd5\u8005\u5229\u76ca\uff0c\u5e94\u9996\u5148\u8003\u8651\u8ba9\u60a3\u8005\u63a5\u53d7\u73b0\u6709\u7684\u6807\u51c6\u7684\u7cfb\u7edf\u6cbb\u7597\u3002\u800c\u5bf9\u4e8e\u514d\u75ab\u7ec6\u80de\u4ea7\u54c1\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5219\u5e94\u9009\u62e9\u5728\u7f3a\u4e4f\u6709\u6548\u6cbb\u7597\u624b\u6bb5\u7684\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\uff08R\/R\uff09\u60a3\u8005\u4e2d\u5f00\u5c55\uff0c\u4ee5\u671f\u60a3\u8005\u53c2\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\u7684\u83b7\u76ca\u80fd\u5927\u4e8e\u98ce\u9669\u3002\u7533\u8bf7\u4eba\u5e94\u5728\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u4e2d\u660e\u786e\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027ALL\u7684\u5b9a\u4e49\uff0c\u4f8b\u5982\u9996\u6b21\u7f13\u89e3\u540e12\u4e2a\u6708\u5185\u590d\u53d1\uff1b\u6807\u51c6\u5316\u7597\u65b9\u68482\u4e2a\u5468\u671f\u672a\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u7684\u521d\u6b21\u96be\u6cbb\uff0c\u6216\u4e00\u7ebf\u6216\u591a\u7ebf\u633d\u6551\u5316\u7597\u540e\u672a\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u6216\u590d\u53d1\uff1b\u6216\u81ea\u4f53\u6216\u5f02\u57fa\u56e0\u9020\u8840\u79fb\u690d\u540e\u590d\u53d1\u7b49\u3002<\/span>
       \u5bf9\u4e8e\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\uff08Ph+\uff09\u7684\u53d7\u8bd5\u8005\uff0c\u53c2\u52a0\u4e34\u5e8a\u8bd5\u9a8c\u524d\u5e94\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e24\u79cd\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\u836f\u7269\u6cbb\u7597\u540e\u590d\u53d1\u6216\u96be\u6cbb\uff0c\u6216\u8005\u4e0d\u8010\u53d7TKI\u7c7b\u836f\u7269\u6cbb\u7597\u3002\u540c\u65f6\uff0c\u9f13\u52b1\u7533\u8bf7\u4eba\u6839\u636e\u4e34\u5e8a\u7814\u7a76\u7684\u65b0\u8fdb\u5c55\u5408\u7406\u8c03\u6574\u53d7\u8bd5\u8005\u7684\u62db\u52df\u6807\u51c6\uff0c\u4f8b\u5982\u4f34t315i\u7a81\u53d8\u7684Ph+ ALL\u60a3\u8005\u5bf9\u4e00\u3001\u4e8c\u4ee3TKI\u7c7b\u836f\u7269\u8010\u836f\uff0c\u5728\u7f3a\u4e4f\u6709\u6548\u7684TKI\u7c7b\u836f\u7269\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u4e0d\u8981\u6c42\u60a3\u8005\u5fc5\u987b\u63a5\u53d7\u81f3\u5c11\u4e24\u79cdTKI\u7c7b\u836f\u7269\u6cbb\u7597\u3002<\/span>

       B\u7ec6\u80de\u6dcb\u5df4\u7624\u662f\u4e00\u7ec4\u8d77\u6e90\u4e8eB\u6dcb\u5df4\u7ec6\u80de\u7684\u5f02\u8d28\u6027\u80bf\u7624\uff0c\u5177\u6709\u4e0d\u540c\u5206\u5b50\u7279\u6027\u548c\u9884\u540e\uff0c\u4e34\u5e8a\u75c5\u7406\u4e9a\u578b\u53ef\u5206\u4e3a\u4fb5\u88ad\u6027\uff08\u751f\u957f\u5feb\u901f\u6216\u9ad8\u7b49\u7ea7\uff0c\u5982\u5f25\u6563\u6027\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\uff09\u548c\u60f0\u6027\uff08\u751f\u957f\u7f13\u6162\u6216\u4f4e\u7b49\u7ea7\uff0c \u5982FL\uff0cCLL\u7b49\uff09\u3002\u4e3a\u4fdd\u62a4\u53d7\u8bd5\u8005\u6743\u76ca\uff0cCAR-T\u7ec6\u80de\u4e34\u5e8a\u7814\u7a76\u5e94\u9009\u62e9\u524d\u671f\u8fdb\u8fc7\u89c4\u8303\u6cbb\u7597\uff0c\u76ee\u524d\u7f3a\u4e4f\u6709\u6548\u6cbb\u7597\u624b\u6bb5\u7684\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u60a3\u8005\u4e2d\u5f00\u5c55\u3002\u7531\u4e8e\u4e0d\u540c\u75c5\u7406\u4e9a\u578b\u60a3\u8005\u53ef\u9009\u62e9\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u548c\u75be\u75c5\u8fdb\u5c55\u7279\u5f81\u4e0d\u540c\uff0c\u9488\u5bf9\u4fb5\u88ad\u6027\u75be\u75c5\u5e94\u8003\u8651\u81f3\u5c11\u4e8c\u7ebf\u6cbb\u7597\u5931\u8d25\u540e\u7684\u60a3\u8005\u3001\u539f\u53d1\u8010\u836f\u3001\u79fb\u690d\u540e\u590d\u53d1\u7684\u60a3\u8005\u3002\u9488\u5bf9\u60f0\u6027\u5165\u9009\u6761\u4ef6\u53ef\u4ee5\u66f4\u4e25\u683c\uff0c\u5e94\u8003\u8651\u5927\u4e8e\u7b49\u4e8e\u4e09\u7ebf\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u3002CD20\u9633\u6027\u60a3\u8005\u5e94\u63a5\u53d7\u8fc7\u76f8\u5e94\u7684\u9776\u5411\u6cbb\u7597\u3002<\/span>

       \u6211\u56fd\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u6cbb\u7597\u9009\u62e9\u5728\u8fd1\u671f\u5df2\u6709\u8f83\u5927\u8fdb\u5c55\uff0c\u591a\u79cd\u6cbb\u7597\u836f\u7269\uff0c\u5305\u62ecCD38\u5355\u6297\u76ee\u524d\u5df2\u6279\u51c6\u4e0a\u5e02\u30022017\u4e2d\u56fd\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u8bca\u6cbb\u6307\u5357\u5df2\u5c06\u787c\u66ff\u4f50\u7c73\uff0c\u6c99\u5229\u5ea6\u80fa\u548c\u6765\u90a3\u5ea6\u80fa\u4f5c\u4e3a\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u5173\u952e\u836f\u7269\u3002<\/span>
       \u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u75c5\u60c5\u8fdb\u5c55\u901a\u5e38\u8f83\u6162\uff0cCAR-T\u4f5c\u4e3a\u4e00\u79cd\u6f5c\u5728\u98ce\u9669\u8f83\u9ad8\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7597\u6cd5\uff0c\u5728\u65e0\u5145\u5206\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u652f\u6301\u524d\uff0c\u5e94\u653e\u5728\u7ecf\u8fc7\u6807\u51c6\u6cbb\u7597\u540e\u7684\u672b\u7ebf\u6cbb\u7597\u66f4\u4e3a\u5408\u9002\uff0c\u5373\u5728\u86cb\u767d\u9176\u6291\u5236\u5242\u53ca\u514d\u75ab\u8c03\u8282\u5242\u6cbb\u7597\u65e0\u6548\u3001\u5728\u63a5\u53d7\u8fc7\u4e09\u7ebf\u4ee5\u4e0a\u6b63\u89c4\u7684\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1\u96be\u6cbb\u60a3\u8005\u3002<\/span>

       \u9f13\u52b1\u7533\u8bf7\u4eba\u5728\u5173\u952e\u7684\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u91c7\u7528\u968f\u673a\u5bf9\u7167\u8bbe\u8ba1\uff0c\u5982\u679c\u968f\u673a\u5bf9\u7167\u7814\u7a76\u4e0d\u53ef\u884c\uff0c\u7533\u8bf7\u4eba\u5e94\u8bf4\u660e\u7406\u7531\u5e76\u89e3\u91ca\u62df\u91c7\u7528\u7684\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u5408\u7406\u6027\u3002<\/span>
       \u5f53\u5173\u952e\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u4e3a\u975e\u968f\u673a\u5bf9\u7167\u7814\u7a76\uff0c\u4e14\u7edf\u8ba1\u5b66\u8bbe\u8ba1\u91c7\u7528\u76ee\u6807\u503c\u6cd5\u65f6\uff0c\u4e3b\u8981\u7597\u6548\u6307\u6807\u7684\u53ef\u4fe1\u533a\u95f4\u4e0b\u9650\uff08\u4f8b\u598295%\u53ef\u4fe1\u533a\u95f4\u4e0b\u9650\uff09\u4e0d\u5e94\u4f4e\u4e8e\u73b0\u6709\u6cbb\u7597\u65b9\u6cd5\u5728\u76ee\u6807\u9002\u5e94\u75c7\u4eba\u7fa4\u4e2d\u7684\u6709\u6548\u7387\uff0c\u5e76\u63d0\u4f9b\u76ee\u6807\u503c\u8bbe\u5b9a\u7684\u4e34\u5e8a\u4f9d\u636e\u548c\u76f8\u5173\u7814\u7a76\u8d44\u6599\u3002\u9776\u503c\uff08target\uff09\u7684\u8bbe\u5b9a\u5e94\u6839\u636e\u63a2\u7d22\u6027\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7814\u7a76\u7ed3\u679c\u3001\u56fd\u5185\u5916\u540c\u7c7b\u4ea7\u54c1\u53ca\u5176\u5b83\u6cbb\u7597\u4ea7\u54c1\u5df2\u7ecf\u53d6\u5f97\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u3001\u73b0\u6709\u6cbb\u7597\u7684\u4e34\u5e8a\u7597\u6548\u7b49\u7efc\u5408\u8003\u8651\u3002<\/span>
       CAR-T\u7ec6\u80de\u662f\u7ecf\u8fc7\u57fa\u56e0\u4fee\u9970\u7684\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\uff0c\u53ef\u80fd\u5bfc\u81f4\u60a3\u8005\u51fa\u73b0\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\uff08CRS\uff09\u3001\u795e\u7ecf\u6bd2\u6027\u7b49\u591a\u79cd\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff0c\u56e0\u6b64\uff0c\u5173\u952e\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u7684\u53d7\u8bd5\u8005\u89c4\u6a21\u5728\u6ee1\u8db3\u57fa\u4e8e\u7597\u6548\u7684\u7edf\u8ba1\u5b66\u5047\u8bbe\u7684\u524d\u63d0\u4e0b\uff0c\u8fd8\u5e94\u63d0\u4f9b\u66b4\u9732CAR-T\u7ec6\u80de\u4ea7\u54c1\u5728\u53d7\u8bd5\u8005\u4e2d\u7684\u5b89\u5168\u6027\u98ce\u9669\u7684\u8f83\u5145\u5206\u7684\u6570\u636e\u3002<\/span>

       \u751f\u5b58\u65f6\u95f4\u662f\u8bc4\u4ef7\u6076\u6027\u80bf\u7624\u6cbb\u7597\u836f\u7269\u7597\u6548\u7684\u91d1\u6807\u51c6\uff0c\u800c\u5bf9\u4e8e\u751f\u5b58\u671f\u8f83\u957f\u7684\u7624\u79cd\u6216\u540e\u7eed\u6cbb\u7597\u5e72\u9884\u8f83\u591a\u7684\u60c5\u51b5\uff0c\u9009\u62e9\u5408\u7406\u7684\u66ff\u4ee3\u7ec8\u70b9\u4e5f\u5177\u6709\u5176\u53ef\u884c\u6027\u3002<\/span>

       \u76ee\u524d\uff0c\u5bf9\u4e8e\u590d\u53d1\u96be\u6cbb\u7684B-ALL\u7684CAR-T\u7ec6\u80de\u6cbb\u7597\uff0c\u56fd\u9645\u4e0a\u901a\u5e38\u91c7\u7528\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4f5c\u4e3a\u7597\u6548\u7684\u8bc4\u4f30\u6807\u51c6\uff0c\u8fd9\u4e00\u65b9\u9762\u662f\u56e0\u4e3aCAR-T\u7ec6\u80de\u6cbb\u7597\u7684\u76ee\u6807\u662f\u957f\u671f\u6301\u7eed\u7f13\u89e3\uff0c\u53e6\u4e00\u65b9\u9762\u5219\u662f\u80bf\u7624\u7f13\u89e3\u4e0e\u751f\u5b58\u65f6\u95f4\u7684\u76f8\u5173\u6027\u3002\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53ef\u4ee5\u5728\u82e5\u5e72\u4e0d\u540c\u65f6\u95f4\u70b9\u5bf9\u53d7\u8bd5\u8005\u7684\u7597\u6548\u6307\u6807\u8fdb\u884c\u8bc4\u4ef7\u3002\u4e3a\u4e86\u66f4\u5ba2\u89c2\u5730\u53cd\u5e94CAR-T\u7ec6\u80de\u4ea7\u54c1\u7684\u7597\u6548\u53ca\u53d7\u8bd5\u8005\u7684\u9884\u540e\uff0c\u4e3b\u8981\u7597\u6548\u6307\u6807\u7684\u8bc4\u4ef7\u65f6\u95f4\u4e0d\u5e94\u77ed\u4e8e\u4e09\u4e2a\u6708\uff0c\u540c\u65f6\u5e94\u5bf9CAR-T\u7ec6\u80de\u4ea7\u54c1\u5728\u53d7\u8bd5\u8005\u4e2d\u7684\u957f\u671f\u7597\u6548\u548c\u5b89\u5168\u6027\u8fdb\u884c\u6301\u7eed\u968f\u8bbf\u3002\u6b64\u5916\uff0c\u9664ORR\u5916\uff0c\u5efa\u8bae\u540c\u65f6\u89c2\u5bdf\u53d7\u8bd5\u8005\u7684\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DOR\uff09\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\uff08PFS\uff09\u548c\u603b\u751f\u5b58\u65f6\u95f4\uff08OS\uff09\u7b49\u7597\u6548\u6307\u6807\uff0c\u4ee5\u5168\u9762\u8bc4\u4ef7\u53d7\u8bd5\u8005\u63a5\u53d7CAR-T\u7ec6\u80de\u6cbb\u7597\u540e\u7684\u4e34\u5e8a\u83b7\u76ca\u60c5\u51b5\u3002<\/span>

       B\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u4e3b\u8981\u77ed\u671f\u7597\u6548\u8bc4\u4f30\u6307\u6807\u53ef\u91c7\u7528ORR\uff0c\u8bc4\u4ef7\u65f6\u95f4\u4e0d\u5e94\u77ed\u4e8e\u4e09\u4e2a\u6708\u3002\u5176\u4ed6\u7597\u6548\u6307\u6807\u5e94\u5305\u62ec\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DOR\uff09\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\uff08PFS\uff09\u548c\u603b\u751f\u5b58\u65f6\u95f4\uff08OS\uff09\u7b49\u3002<\/span>
       \u6b64\u5916\uff0c\u57fa\u4e8e\u76ee\u524d\u5df2\u7ecf\u83b7\u6279\u4e0a\u5e02\u7684CAR-T\u7ec6\u80de\u6cbb\u7597B\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u6548\u679c\uff0c\u7ed3\u5408\u4e0d\u540c\u75c5\u7406\u4e9a\u578b\u4e0d\u5c3d\u76f8\u540c\u7684\u6cbb\u7597\u76ee\u6807\uff0c\u53ef\u4ee5\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u8fdb\u4e00\u6b65\u6536\u96c6\u5bf9\u4e34\u5e8a\u8bc4\u4ef7\u66f4\u6709\u610f\u4e49\u7684\u77ed\u671f\u7597\u6548\u6307\u6807\u3002\u5176\u4e2d\uff0c\u4fb5\u88ad\u6027\u75be\u75c5\u8fdb\u5c55\u5feb\uff0c\u5982\u7ecf\u6cbb\u7597\u540e\u672a\u80fd\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u5219\u53ef\u80fd\u4e8e\u77ed\u671f\u5185\u590d\u53d1\uff0c\u60a3\u8005\u6700\u7ec8\u7684\u751f\u5b58\u83b7\u76ca\u4e0d\u663e\u8457\u3002\u56e0\u6b64\uff0c\u5bf9\u4e8e\u5982\u5f25\u6563\u6027\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\u7b49\u4fb5\u88ad\u6027\u75be\u75c5\u4e9a\u578b\uff0c\u5e94\u91cd\u70b9\u5173\u6ce8\u5b8c\u5168\u7f13\u89e3\u7387\uff0c\u8bc4\u4ef7\u65f6\u95f4\u81f3\u5c11\u4e3a3\u4e2a\u6708\u3002<\/span>

       \u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u76ee\u524d\u5e38\u7528\u7684\u77ed\u671f\u7597\u6548\u8bc4\u4ef7\u6307\u6807\u4e3a\u6839\u636e\u56fd\u9645\u9aa8\u9ad3\u7624\u5de5\u4f5c\u7ec4\uff08IMWG\uff09\u7684\u7597\u6548\u6807\u51c6\u8bc4\u4f30\u7684ORR\u3002\u8003\u8651\u5230\u8be5\u75be\u75c5\u8fdb\u5c55\u53ef\u80fd\u8f83\u6162\uff0cCAR-T\u7ec6\u80de\u6cbb\u7597\u7684\u77ed\u671f\u7597\u6548\u8bc4\u4ef7\u65f6\u95f4\u81f3\u5c11\u4e3a3\u4e2a\u6708\u4ee5\u4e0a\u3002\u5176\u4ed6\u7684\u7597\u6548\u6307\u6807\u53ef\u5305\u62ecMRD\u9634\u6027\u7684\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u603b\u751f\u5b58\u671f\uff08OS\uff09\u7b49\u3002<\/span>

       CAR-T\u7ec6\u80de\u4ea7\u54c1\u662f\u4e00\u7c7b\u6d3b\u7ec6\u80de\u4ea7\u54c1\uff0c\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u70b9\u4e0e\u4f20\u7edf\u7684\u5316\u5b66\u6216\u751f\u7269\u836f\u7269\u6709\u660e\u663e\u5dee\u5f02\uff0c\u56de\u8f93\u4f53\u5185\u540e\u53ef\u80fd\u589e\u6b96\u5e76\u5b58\u6d3b\u8f83\u957f\u65f6\u95f4\u3002\u7533\u8bf7\u4eba\u5e94\u6839\u636eCAR-T\u7ec6\u80de\u4ea7\u54c1\u7684\u7c7b\u578b\uff0c\u5728\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u4e2d\u5236\u5b9a\u79d1\u5b66\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u68c0\u6d4b\u65b9\u6cd5\u3002\u5982\u679c\u4e00\u79cd\u65b9\u6cd5\u4e0d\u80fd\u5b8c\u5168\u53cd\u6620\u7ec6\u80de\u5728\u4f53\u5185\u7684PK\u7279\u6027\uff0c\u5efa\u8bae\u7533\u8bf7\u4eba\u91c7\u7528\u591a\u79cd\u68c0\u6d4b\u6280\u672f\uff08\u5982qPCR\u548c\u6d41\u5f0f\u7ec6\u80de\u6cd5\uff09\u5145\u5206\u7814\u7a76\u7ec6\u80de\u5728\u4f53\u5185\u7684\u589e\u6b96\u548c\u5b58\u6d3b\u60c5\u51b5\u3002<\/span>
       CAR-T\u7ec6\u80de\u7ecf\u8fc7\u57fa\u56e0\u6539\u9020\u540e\u56de\u8f93\u8fdb\u5165\u4f53\u5185\uff0c\u8be5\u7ec6\u80de\u5408\u6210\u7684\u5916\u6e90\u86cb\u767d\u53ef\u901a\u8fc7\u523a\u514d\u75ab\u7cfb\u7edf\u4ea7\u751f\u76f8\u5e94\u7684\u6297\u4f53\uff0c\u5e94\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u5173\u6ce8\u662f\u5426\u5b58\u5728CAR-T\u7ec6\u80de\u5236\u5242\u7684\u6297\u4f53\u3002<\/span>
       \u8003\u8651\u5230CAR-T\u4ea7\u54c1\u4f5c\u4e3a\u65b0\u5174\u7684\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\uff0c\u7531\u4e8e\u4e0d\u540c\u79cd\u5c5e\u52a8\u7269\u4e0e\u4eba\u7c7b\u7684\u514d\u75ab\u7cfb\u7edf\u5b58\u5728\u8f83\u5927\u533a\u522b\uff0c\u4e14\u6b64\u7c7b\u4ea7\u54c1\u5236\u5907\u5de5\u827a\u590d\u6742\uff0c\u4e34\u5e8a\u53d7\u8bd5\u8005\u4e2a\u4f53\u5dee\u5f02\u8f83\u5927\uff0c\u4e34\u5e8a\u5e94\u7528\u7ecf\u9a8c\u6709\u9650\uff0c\u6545\uff0c\u76ee\u524d\u5728\u5bf9CAR-T\u7ec6\u80de\u7597\u6548\u548c\u5b89\u5168\u6027\u76f8\u5173\u7684\u591a\u4e2a\u65b9\u9762\u7f3a\u4e4f\u5fc5\u8981\u548c\u6df1\u5165\u7684\u7814\u7a76\u3002\u56e0\u6b64\u9f13\u52b1\u7533\u8bf7\u4eba\u5728\u4e34\u5e8a\u7814\u7a76\u8fc7\u7a0b\u4e2d\u8fdb\u884c\u6709\u76ca\u7684\u63a2\u7d22\u6027\u7814\u7a76\uff0c\u5982\uff0c\u4e0d\u540cT\u7ec6\u80de\u4e9a\u7fa4\u5bf9\u836f\u6548\u5b66\u3001\u5b89\u5168\u6027\u548c\u4e34\u5e8a\u6d3b\u6027\u5f71\u54cd\uff0c\u6cbb\u7597\u540e\u7f13\u89e3\u6216\u8010\u836f\u6027\u7684\u9884\u6d4b\u6027\u751f\u7269\u6807\u8bb0\u7269\u7b49\uff0c\u4e3a\u6b64\u7c7b\u4ea7\u54c1\u540e\u7eed\u7684\u7814\u53d1\u548c\u5e94\u7528\u63d0\u4f9b\u5fc5\u8981\u7684\u6570\u636e\u3002<\/span>
\u4e09\u3001\u4e34\u5e8a\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\u7684\u98ce\u9669\u63a7\u5236<\/strong>
       \u56fd\u5185\u5916\u4e34\u5e8a\u8bd5\u9a8c\u7ecf\u9a8c\u663e\u793a\uff0cCAR-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\uff0c\u662f\u7ecf\u57fa\u56e0\u4fee\u9970\u7684\uff0c\u53ef\u80fd\u5bfc\u81f4\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u3001\u795e\u7ecf\u6bd2\u6027\u3001\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\uff08TLS\uff09\u3001\u5de8\u566c\u7ec6\u80de\u6fc0\u6d3b\u7efc\u5408\u5f81\u7b49\u4e0d\u826f\u53cd\u5e94\u3002\u8fd1\u5e74\u6765\uff0c\u968f\u7740CRISPR\/Cas9\u7b49\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5728\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u7684\u5e94\u7528\uff0c\u65b0\u4ea7\u54c1\u548c\u65b0\u6280\u672f\u4e5f\u7ed9\u60a3\u8005\u5e26\u6765\u5f88\u591a\u6f5c\u5728\u7684\u5b89\u5168\u6027\u98ce\u9669\uff0c\u4f8b\u5982\u8131\u9776\u6548\u5e94\u3001\u81f4\u7624\u6027\u7b49\u3002\u56e0\u6b64\uff0c\u5b89\u5168\u6027\u98ce\u9669\u7684\u63a7\u5236\u65b9\u6848\u662f\u8861\u91cfCAR-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u548c\u5b9e\u65bd\u80fd\u529b\u6700\u5173\u952e\u7684\u8003\u8651\u56e0\u7d20\u4e4b\u4e00\u3002<\/span>
       \u5728\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u4e2d\uff0c\u987b\u660e\u786e\u7533\u8bf7\u4eba\u548c\u7814\u7a76\u8005\u7684\u8d23\u4efb\u53ca\u5bf9\u53d7\u8bd5\u8005\u51fa\u73b0\u91cd\u5927\u98ce\u9669\u7684\u4fdd\u969c\u63aa\u65bd\u3002\u9700\u6839\u636e\u4ea7\u54c1\u7279\u70b9\uff0c\u9488\u5bf9\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53ef\u80fd\u51fa\u73b0\u7684\u5b89\u5168\u6027\u98ce\u9669\uff0c\u5236\u5b9a\u5168\u9762\u3001\u53ef\u64cd\u4f5c\u7684\u98ce\u9669\u63a7\u5236\u65b9\u6848\u3002\u5e94\u5206\u522b\u5bf9\u5177\u4f53\u98ce\u9669\u7684\u9884\u9632\u3001\u8bc6\u522b\u3001\u8bca\u65ad\u3001\u5904\u7406\u548c\u9884\u540e\u968f\u8bbf\u7b49\u8fdb\u884c\u8be6\u7ec6\u63cf\u8ff0\u3002\u5efa\u8bae\u7533\u8bf7\u4eba\u5728\u5236\u5b9a\u98ce\u9669\u63a7\u5236\u65b9\u6848\u65f6\uff0c\u53c2\u8003\u56fd\u5185\u5916\u5df2\u7ecf\u5f62\u6210\u7684\u4e34\u5e8a\u5171\u8bc6\u6216\u8005\u6700\u65b0\u7684\u6743\u5a01\u7814\u7a76\u7ed3\u679c\uff0c\u63d0\u9ad8\u98ce\u9669\u63a7\u5236\u63aa\u65bd\u7684\u79d1\u5b66\u6027\u548c\u5408\u7406\u6027\u3002\u4f8b\u5982\uff0c\u56fd\u5185\u5916\u4e34\u5e8a\u4e13\u5bb6\u5bf9CART\u7ec6\u80de\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5982CRS\u3001\u795e\u7ecf\u6bd2\u6027\u3001\u5de8\u566c\u7ec6\u80de\u6fc0\u6d3b\u7efc\u5408\u5f81\u7b49\u5df2\u7ecf\u6709\u6bd4\u8f83\u6e05\u695a\u7684\u8ba4\u8bc6\uff0c\u5f88\u591aCAR-T\u7ec6\u80de\u6cbb\u7597\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u7684\u5206\u7ea7\u548c\u63a7\u5236\u65b9\u6cd5\u5df2\u7ecf\u5728Lancet\u3001Blood\u3001Nature Reviews Clinical Oncology\u7b49\u56fd\u9645\u6743\u5a01\u5b66\u672f\u6742\u5fd7\u4e0a\u53d1\u8868\uff0c\u5e76\u5728\u56fd\u5185\u5916\u4e34\u5e8a\u533b\u751f\u4e2d\u8fbe\u6210\u4e86\u5e7f\u6cdb\u5171\u8bc6\uff0c\u5bf9\u4e8e\u6709\u6548\u63a7\u5236\u4e34\u5e8a\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\u7684\u5b89\u5168\u6027\u98ce\u9669\u6709\u91cd\u8981\u7684\u53c2\u8003\u4ef7\u503c\u3002<\/span>
       \u6b64\u5916\uff0c\u8003\u8651\u5230CAR-T\u7ec6\u80de\u6cbb\u7597\u5177\u6709\u8f83\u9ad8\u7684\u5b89\u5168\u6027\u98ce\u9669\uff0c\u5bf9\u7814\u7a76\u8005\u7684\u4e34\u5e8a\u7ecf\u9a8c\u548c\u6280\u672f\u6c34\u5e73\u8981\u6c42\u8f83\u9ad8\uff0c\u5e76\u9700\u8981\u4fdd\u8bc1\u6025\u6551\u836f\u7269\u7684\u50a8\u5907\u6709ICU\u7b49\u76f8\u5173\u79d1\u5ba4\u7684\u914d\u5408\u652f\u6301\uff0c\u5e76\u5bf9\u7814\u7a76\u8005\u8fdb\u884c\u6709\u6548\u548c\u89c4\u8303\u7684\u57f9\u8bad\u3002\u5c24\u5176\u5728\u65e9\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u7533\u8bf7\u4eba\u5e94\u8003\u8651\u9009\u62e9\u6709\u7ec6\u80de\u6cbb\u7597\u7ecf\u9a8c\u4ee5\u53ca\u4e0d\u826f\u53cd\u5e94\u8bca\u65ad\u548c\u5904\u7f6e\u80fd\u529b\u7684\u533b\u7597\u673a\u6784\u548c\u7814\u7a76\u8005\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5728\u5f00\u5c55\u65e9\u671f\u5242\u91cf\u63a2\u7d22\u7814\u7a76\u65f6\uff0c\u5e94\u8bbe\u7f6e\u5408\u7406\u7684\u5165\u7ec4\u65f6\u95f4\u95f4\u9694\uff0c\u5efa\u8bae\u6bcf\u4e2a\u5242\u91cf\u6c34\u5e73\u7684\u53d7\u8bd5\u8005\u5165\u7ec4\u95f4\u9694\u4e0d\u5c11\u4e8e2\u5468\uff0c\u4ee5\u5145\u5206\u89c2\u5bdf\u6bcf\u4f4d\u53d7\u8bd5\u8005\u5728\u7ec6\u80de\u56de\u8f93\u540e\u662f\u5426\u51fa\u73b0CRS\u3001\u795e\u7ecf\u6bd2\u6027\u7b49\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff0c\u786e\u4fdd\u60a3\u8005\u53c2\u4e0eCAR-T\u7ec6\u80de\u6cbb\u7597\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5b89\u5168\u6027\u3002\u4e3a\u4e86\u786e\u4fdd\u5b89\u5168\u6027\u76d1\u6d4b\uff0c\u7533\u529e\u65b9\u53ef\u8003\u8651\u6210\u7acb\u6709\u591a\u4e13\u4e1a\u5bcc\u6709\u7ecf\u9a8c\u7684\u6210\u5458\u7ec4\u6210\u7684\u5b89\u5168\u6027\u8bc4\u4f30\u5c0f\u7ec4\uff0c\u8ba8\u8bba\u4e34\u5e8a\u7814\u7a76\u4e2d\u53d7\u8bd5\u8005\u5b89\u5168\u6027\u95ee\u9898\uff0c\u4e3a\u7533\u529e\u65b9\u63d0\u4f9b\u51b3\u7b56\u7684\u5efa\u8bae\u3002<\/span>
       \u7533\u8bf7\u4eba\u5e94\u5728\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u4e2d\u5145\u5206\u6536\u96c6\u4e0d\u826f\u53cd\u5e94\u6570\u636e\uff0c\u5728\u4e34\u5e8a\u7814\u53d1\u8fc7\u7a0b\u4e2d\u4e0d\u65ad\u5b8c\u5584\u98ce\u9669\u63a7\u5236\u65b9\u6848\u3002\u8fd1\u671f\u5b89\u5168\u6027\u968f\u8bbf\u65f6\u95f4\u53ef\u6839\u636e\u524d\u671f\u836f\u4ee3\u52a8\u529b\u5b66\u6570\u636e\u5408\u7406\u8bbe\u7f6e\uff0c\u5982\u53ef\u968f\u8bbf\u81f3\u4f53\u5185\u68c0\u6d4b\u4e0d\u5230\u672c\u54c1\u6216\u8f93\u6ce8\u540e2\u5e74\uff0c\u4ee5\u65f6\u95f4\u957f\u8005\u4e3a\u51c6\u3002\u540c\u65f6\uff0c\u7531\u4e8eCAR-T\u7ec6\u80de\u7ecf\u8fc7\u57fa\u56e0\u7f16\u8f91\u6539\u9020\uff0c\u6709\u6f5c\u5728\u7684\u81f4\u7624\u6027\u98ce\u9669\uff0c\u5728\u7f3a\u4e4f\u5145\u8db3\u7684\u957f\u671f\u968f\u8bbf\u6570\u636e\u524d\uff0c\u5e94\u5bf9\u53d7\u8bd5\u8005\u7684\u81f4\u7624\u6027\u8fdb\u884c\u7ec8\u8eab\u968f\u8bbf\u6216\u81f3\u5c11\u6301\u7eed15\u5e74\u3002<\/span>
[\u53c2\u8003\u6587\u732e]<\/strong>
       [1] Tang J, Hubbard-Lucey VM, Pearce L, et al. The global landscape of cancer cell therapy[J]. Nat Rev Drug Discov 2018;17(7):465-466. <\/span>
       [2] Gou L, Gao J, Yang H, et al. The landscape of CAR T-cell therapy in the United States and China: a comparative analysis[J]. Int J Cancer 2018; 10.1002\/ijc.31924. <\/span>
       [3] \u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u8840\u6db2\u80bf\u7624\u4e13\u4e1a\u59d4\u5458\u4f1a. \u4e2d\u56fd\u6210\u4eba\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u8bca\u65ad\u4e0e\u6cbb\u7597\u6307\u5357(2016\u5e74\u7248)[J]. \u4e2d\u534e\u8840\u6db2\u5b66\u6742\u5fd7, 2016, 37(10):837-845.<\/span>
       [4] \u4e2d\u534e\u533b\u5b66\u4f1a\u513f\u79d1\u5b66\u5206\u4f1a\u8840\u6db2\u5b66\u7ec4. \u513f\u7ae5\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u8bca\u7597\u5efa\u8bae\uff08\u7b2c\u56db\u6b21\u4fee\u8ba2\uff09[J].\u4e2d\u534e\u513f\u79d1\u6742\u5fd7.2014,52(9):641-644.<\/span>
       [5] \u77f3\u8fdc\u51ef,\u5b59\u71d5,\u5218\u5f64\u534e. \u4e2d\u56fd\u6076\u6027\u6dcb\u5df4\u7624\u8bca\u7597\u89c4\u8303(2015\u5e74\u7248)[J] \u4e2d\u534e\u80bf\u7624\u6742\u5fd7.2015,37(2):148-158.<\/span>
       [6] \u4e2d\u534e\u533b\u5b66\u4f1a\u513f\u79d1\u5b66\u5206\u4f1a\u8840\u6db2\u5b66\u7ec4,\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u513f\u79d1\u4e13\u4e1a\u59d4\u5458\u4f1a,\u300a\u4e2d\u534e\u513f\u79d1\u6742\u5fd7\u300b\u7f16\u8f91\u59d4\u5458\u4f1a.\u513f\u7ae5\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u8bca\u7597\u5efa\u8bae[J].\u4e2d\u534e\u513f\u79d1\u6742\u5fd7,2011,49(3):186-192.<\/span>
       [7] \u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u8840\u6db2\u79d1\u533b\u5e08\u5206\u4f1a,\u4e2d\u534e\u533b\u5b66\u4f1a\u8840\u6db2\u5b66\u5206\u4f1a,\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u4e13\u4e1a\u59d4\u5458\u4f1a.\u4e2d\u56fd\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u8bca\u6cbb\u6307\u5357(2017\u5e74\u4fee\u8ba2)[J].\u4e2d\u534e\u5185\u79d1\u6742\u5fd7,2017,56(11):866-870.<\/span>
       [8] Neelapu S.S., Tummala S, Kebriaei P, et al. Chimeric antigen receptor T-cell therapy-assessment and management of toxicities[J]. Nature Reviews Clinical Oncology, 2017, 15(1).<\/span>
       [9] Brudno J.N., Kochenderfer J.N.. Toxicities of chimeric antigen receptor T cells: recognition and management.[J]. Blood, 2016, 127(26):3321.<\/span>
       [10] Neelapu S.S., Tummala S., Kebriaei P, et al. Toxicity management after chimeric antigen receptor T cell therapy: one size does not fit “ALL”[J]. Nature Reviews Clinical Oncology, 2018, 15(4).<\/span>
       [11] Lee DW, Gardner R, Porter DL, et al. Current concepts in the diagnosis and management of cytokine release syndrome[J].Blood.2014;124(2):188-195.<\/span>
       [12] Maude, S.L., T.W. Laetsch, J. Buechner, et al., Tisagenlecleucel in Children and Young Adults with B- Lymphoblastic Leukemia[J]. N Engl J Med, 2018. 378(5): 439-448.<\/span>
       [13] Neelapu, S.S., F.L. Locke, N.L. Bartlett, et al., Axicabtagene Ciloleucel CAR T- Therapy in Refractory Large B- Lymphoma[J]. N Engl J Med, 2017. 377(26): 2531-2544.<\/span>
       [14] FDA. Guidance for Industry Gene Therapy Clinical Trials \u2013 Observing Subjects for Delayed Adverse Events [EB\/OL]. (2006-11)https:\/\/www.fda.gov\/downloads\/biologicsbloodvaccines\/guidancecomplianceregulatoryinformation\/guidances\/cellularandgenetherapy\/ucm078719.pdf<\/span>
       [15] EMA. Follow-up of patients administered with gene therapy medicinal products [EB\/OL].(2010-01-05) <\/span>https:\/\/www.ema.europa.eu\/follow-patients-administered-gene-therapy-medicinal-products<\/p>\n


<\/p>\n

\u6765\u6e90\uff1aClindata<\/span><\/p>\n


<\/p>\n


<\/p>\n

\"CDE\u53d1\u5e03\u300a\u5bf9\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u6dcb\u5df4\u7ec6\u80de\u6cbb\u7597\u6dcb\u5df4\u9020\u8840\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u8003\u8651\u300b\"<\/section>\n
\n


<\/p>\n

\u66f4\u591a\u7cbe\u5f69\u5185\u5bb9\uff1a\"CDE\u53d1\u5e03\u300a\u5bf9\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u6dcb\u5df4\u7ec6\u80de\u6cbb\u7597\u6dcb\u5df4\u9020\u8840\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u8003\u8651\u300b\"<\/span><\/p>\n