{"id":6981,"date":"2018-06-09T01:00:00","date_gmt":"2018-07-27T09:20:00","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e7%9c%8b%e4%b8%8d%e8%a7%81%e7%9a%84%e6%88%98%e4%ba%89%ef%bc%9a%e5%8e%9f%e7%a0%94%e8%8d%af-vs-%e4%bb%bf%e5%88%b6%e8%8d%af-%e7%99%bd%e8%a1%80%e7%97%85%e7%af%87\/"},"modified":"2018-07-27T17:20:04","modified_gmt":"2018-07-27T09:20:04","slug":"%e7%9c%8b%e4%b8%8d%e8%a7%81%e7%9a%84%e6%88%98%e4%ba%89%ef%bc%9a%e5%8e%9f%e7%a0%94%e8%8d%af-vs-%e4%bb%bf%e5%88%b6%e8%8d%af-%e7%99%bd%e8%a1%80%e7%97%85%e7%af%87","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/6981\/","title":{"rendered":"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532683201.jpeg\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u968f\u7740\u56fd\u5bb6\u4e0d\u65ad\u5bf9\u5916\u5f00\u653e\u8fdb\u53e3\u521b\u65b0\u6297\u764c\u836f\u7684\u5e02\u573a\uff0c\u56fd\u5185\u7684\u60a3\u8005\u53ef\u4ee5\u5f97\u5230\u66f4\u5feb\u901f\u66f4\u6709\u6548\u7684\u6cbb\u7597\u3002\u8fd9\u4e00\u653f\u7b56\u5728\u5e26\u6765\u516c\u5171\u5065\u5eb7\u798f\u7949\u7684\u540c\u65f6\uff0c\u4e5f\u6fc0\u8d77\u4e86\u56fd\u5185\u5916\u836f\u4f01\u7684\u7ade\u4e89\u3002<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5916\u4f01\u5c06\u8fdb\u4e00\u6b65\u62a2\u5360\u4e2d\u56fd\u5e02\u573a\u5217\u5165\u65e5\u7a0b\uff0c\u56fd\u5185\u7684\u836f\u4f01\u4e5f\u4e0d\u7518\u793a\u5f31\uff0c\u7eb7\u7eb7\u5f00\u59cb\u4e89\u593a\u5404\u4e2a\u91cd\u78c5\u521b\u65b0\u836f\u7684\u9996\u4eff\u8d44\u8d28\u3002\u8fd1\u671f\u56fd\u5bb6\u653f\u7b56\u4e5f\u4fc3\u8fdb\u548c\u652f\u6301\u548c\u521b\u65b0\u836f\u7597\u6548\u4e00\u81f4\u7684\u4eff\u5236\u836f\u7814\u53d1\u3002\u5728\u8fd9\u4e2a\u4e16\u754c\u91cd\u78c5\u521b\u65b0\u836f\u63a5\u8fde\u9762\u4e34\u4e13\u5229\/\u4e13\u8425\u6743\u5230\u671f\u7684\u8d8b\u52bf\u4e0b\uff0c\u53cc\u65b9\u5230\u5e95\u8c01\u80fd\u6700\u7ec8\u8d62\u5f97\u5e02\u573a\u8fd8\u672a\u53ef\u77e5\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u53e4\u4eba\u4e91\uff0c\u4ee5\u53f2\u4e3a\u9274\uff0c\u53ef\u4ee5\u77e5\u5174\u66ff\u3002\u4eca\u5929\u7b14\u8005\u6311\u9009\u4e86\u4e09\u4e2a\u5df2\u7ecf\u88ab\u4eff\u5236\u7684\u767d\u8840\u75c5\u836f\uff0c\u5b83\u4eec\u90fd\u6709\u7740\u767e\u8f6c\u5343\u56de\u7684\u7ecf\u5386\u3002\u8ba9\u6211\u4eec\u770b\u770b\u8fd9\u4e9b\u836f\u8fd1\u5e74\u7684\u52bf\u5934\u5982\u4f55\uff0c\u5b83\u4eec\u7684\u6545\u4e8b\u53c8\u80fd\u7ed9\u6211\u4eec\u4ec0\u4e48\u6837\u7684\u542f\u53d1\u3002<\/span><\/p>\n<p style=\"margin-top: 5px;margin-bottom: 5px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6587\/\u9ad8\u6587\u6167<\/span><\/p>\n<p style=\"margin-top: 5px;margin-bottom: 5px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);letter-spacing: 1px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7f16\/HLR<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);letter-spacing: 1px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;letter-spacing: 0.5px;font-size: 32px;color: rgb(59, 179, 195);box-sizing: border-box !important;word-wrap: break-word !important;\">1<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(59, 179, 195);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(59, 179, 195);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u76d0\u9178\u82ef\u8fbe\u83ab\u53f8\u6c40\u2014\u2014\u6536\u8d2d\u7ade\u4e89\u5bf9\u624b<\/span><\/strong><\/span><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u82ef\u8fbe\u83ab\u53f8\u6c40\u662f\u4e00\u79cd\u53cc\u529f\u80fd\u57fa\u70f7\u5316\u5242\uff0c\u53ef\u4ee5\u901a\u8fc7DNA\u6216\u86cb\u767d\u4e4b\u95f4\u7684\u4ea4\u8054\u53cd\u5e94\uff0c\u5e72\u6270DNA\u7684\u529f\u80fd\u53ca\u5408\u6210\uff0c\u4ece\u800c\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528[1]\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"margin-right: 48px;margin-left: 48px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1532683201.jpeg\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">2008\u5e7410\u6708\uff0cCephalon\u516c\u53f8\u751f\u4ea7\u7684Treanda\uff0cbendamustine\uff08\u76d0\u9178\u82ef\u8fbe\u83ab\u53f8\u6c40\u6ce8\u5c04\u5242\uff09\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08Chronic Lymphocytic Leukemia\uff0cCLL\uff09[2]\u3002\u56e0\u4e3a\u8fd9\u4e2a\u836f\u6709FDA\u7684\u5b64\u513f\u836f\uff08Orphan drug\uff0c\u4ea6\u79f0\u6cbb\u7597\u7f55\u89c1\u75c5\u7684\u836f\u7269\uff09\u548c\u513f\u79d1\u836f\u8ba4\u8bc1\uff0cTreanda\u7528\u4e8e\u6cbb\u7597CLL\u7684\u4e13\u8425\u6743\u53ef\u4ee5\u5ef6\u7eed\u52302015\u5e749\u6708\uff0c\u6bd4\u666e\u901a\u5316\u5b66\u539f\u7814\u836f\u65f6\u95f4\u66f4\u957f\u4e00\u4e9b[3]\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"margin-right: 48px;margin-left: 48px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;height: 201.585px !important;box-sizing: border-box !important;word-wrap: break-word !important;width: 534px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532683202.png\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">2011\u5e745\u6708\uff0cTeva\u4ee568\u4ebf\u7f8e\u5143\u6536\u8d2dCephalon[4]\uff0c\u5e76\u4e8e\u6b21\u5e74\u5c06Treanda\u7684\u9500\u552e\u989d\u4ece1.31\u4ebf\u7f8e\u5143\u6269\u5927\u52306.08\u4ebf\u7f8e\u5143\uff0c\u589e\u957f\u7387\u8d85\u8fc73\u500d\u3002\u6536\u8d2d\u5b8c\u6210\u540e\uff0cTeva\u57282013\u5e74\u53c8\u5411FDA\u7533\u8bf7\u4e86\u6162\u6027\u975e\u970d\u5947\u91d1\u6c0f\u6dcb\u5df4\u7624\uff08Indolent Non-Hodgkin Lymphoma\uff0ciNHL\uff09\u7684\u9002\u5e94\u75c7\uff0c\u8be5\u9002\u5e94\u75c7\u7684\u4e13\u8425\u6743\u4e8e2016\u5e744\u6708\u7ed3\u675f[3]\u3002\u6b64\u523b\u597d\u6d88\u606f\u4e0d\u65ad\u7684Treanda\uff0c\u9500\u552e\u989d\u4e00\u5ea6\u57282014\u5e74\u589e\u957f\u52307.67\u4ebf\u7f8e\u5143[5]\u3002<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;height: 372.047px !important;box-sizing: border-box !important;word-wrap: break-word !important;width: 630px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532683202.jpg\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7136\u800c\uff0cTeva\u72ec\u5360\u5e02\u573a\u7684\u597d\u65e5\u5b50\u5e76\u4e0d\u957f\u4e45\uff0c2015\u5e74Eagle\u5236\u836f\u4ee5\u540c\u6837\u7684\u836f\u7269\u6d3b\u6027\u6210\u5206\uff08Active Pharmaceutical Ingredient\uff0cAPI\uff09\u7814\u5236\u51fa\u4e86Bendeka\uff0c\u5e76\u5c06\u5242\u578b\u7531\u6ce8\u5c04\u5242\u6539\u4e3a10\u5206\u949f\u7684\u8f93\u6db2\uff0c\u4ee5\u76f8\u540c\u7684\u9002\u5e94\u75c7\u5411FDA\u63d0\u51fa\u4e86NDA\uff08New Drug Application\uff09\u7533\u8bf7[6]\u3002\u6b64\u65f6Treanda\u4e24\u4e2a\u9002\u5e94\u75c7\u7684\u4e13\u8425\u6743\u90fd\u903c\u8fd1\u622a\u6b62\u65e5\u671f\uff0cFDA\u867d\u7136\u4e0d\u4f1a\u5728\u5b64\u513f\u836f\u548c\u513f\u79d1\u836f\u7684\u4e13\u8425\u6743\u671f\u95f4\u6279\u51c6\u4eff\u5236\u836f\uff0c\u4f46\u4f9d\u7136\u53ef\u4ee5\u63a5\u53d7\u7533\u8bf7[7]\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;width: 252px;word-wrap: break-word !important;overflow: hidden !important;\"><img    width=\"100%\" class=\"\"  style=\"box-sizing: border-box;border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);vertical-align: middle;background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;height: 275.406px !important;word-wrap: break-word !important;width: 252px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532683202.jpg\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4f30\u7b97\u4e00\u4e0b\u4e0d\u96be\u770b\u51fa\uff0cTreanda\u4e00\u65e6\u5931\u53bb\u4e13\u8425\u6743\uff0cEagle\u7684\u7533\u8bf7\u7acb\u523b\u5c31\u80fd\u88ab\u6279\u51c6\u3002Teva\u60c5\u6025\u4e4b\u4e0b\uff0c\u4e3a\u4e86\u4fdd\u4f4f\u5e02\u573a\u5784\u65ad\u5730\u4f4d\uff0c\u7d22\u6027\u4e70\u4e0b\u4e86\u8be5\u836f\u5728\u7f8e\u56fd\u7684\u72ec\u5bb6\u9500\u552e\u6743\u3002\u52a0\u4e0a3000\u4e07\u7f8e\u5143\u7684\u9996\u4ed8\uff0c\u8be5\u9879\u4ea4\u6613\u6240\u503c\u91d1\u989d\u6700\u9ad8\u53ef\u8fbe1.2\u4ebf\u7f8e\u5143[8]\u3002<span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6700\u7ec8\uff0cTeva\u540c\u610fEagle\u7684Bendeka\u5728\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08Non-Hodgkin Lymphoma\uff0cNHL\uff09\u4e13\u8425\u6743\u5230\u671f\u524d\u83b7\u5f97\u4e24\u4e2a\u9002\u5e94\u75c7\u7684\u4e0a\u5e02\u6279\u51c6<\/span>[9]\uff0c\u7686\u5927\u6b22\u559c\u3002\u4f46\u8fd9\u4f9d\u7136\u4e0d\u80fd\u963b\u6b62Treanda\u5728\u4e4b\u540e\u7684\u51e0\u5e74\u91cc\uff0c\u9010\u6e10\u5931\u53bb\u5bf9\u5e02\u573a\u7684\u638c\u63a7\u3002<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin: 25px 48px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;height: 168px !important;box-sizing: border-box !important;word-wrap: break-word !important;width: 299px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532683202.png\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">2016\u5e743\u6708\uff0c\u5370\u5ea6\u5236\u836f\u516c\u53f8Glenmark Pharma\uff08\u683c\u4f26\u9a6c\u514b\u5236\u836f\uff09\u83b7\u5f97\u4e86FDA\u6279\u51c6\u7684\u76d0\u9178\u82ef\u8fbe\u83ab\u53f8\u6c40\u9996\u4eff\u836f[10]\u3002\u622a\u81f3\u73b0\u5728\uff0c\u5171\u67099\u5bb6\u516c\u53f8\u83b7\u5f97\u4e86Treanda\u4eff\u5236\u836f\u6279\u51c6\uff0c\u800c\u4e14Eagle\u4e5f\u53e6\u7acb\u95e8\u6237\u53c8\u83b7\u5f97\u4e86\u4e00\u4e2aNDA\u6279\u51c6\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u73b0\u5728\u5171\u670910\u5bb6\u516c\u53f8\u5728\u7ade\u4e89Treanda\u7684\u5e02\u573a\uff0c\u8fd9\u5bf9\u4e8eTeva\u6765\u8bf4\u65e0\u7591\u662f\u6674\u7a7a\u9739\u96f3\u3002Treanda\u548cBendeka\u7684\u9500\u552e\u603b\u548c\u52302017\u5e74\u5e95\u5df2\u4e0b\u964d\u81f36.58\u4ebf\u7f8e\u5143\uff0c\u8f832014\u5e74\u9ad8\u5cf0\u65f6\u671f\u4f4e\u4e8614.2%\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u76ee\u524d\uff0c\u76d0\u9178\u82ef\u8fbe\u83ab\u53f8\u6c40\u5728\u4e2d\u56fd\u5171\u67094\u5bb6\u516c\u53f8\u63d0\u4ea4\u4e86\u4e0a\u5e02\u7533\u8bf7\u3002\u9664\u4e86Cephalon\u7533\u8bf7\u8fdb\u53e3\u836f\u4ee5\u5916\uff0c\u56fd\u5185\u516c\u53f8\u5148\u58f0\u4e1c\u5143\u3001\u6b63\u5927\u5929\u6674\u548c\u534e\u90a6\u5236\u836f\u5747\u7533\u8bf7\u4e86\u4eff\u5236\u836f\u4e0a\u5e02\u3002\u5176\u4e2d\uff0c\u5148\u58f0\u4e1c\u5143\u7533\u62a5\u4e86\u6162\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\uff08CLL\uff09\u9002\u5e94\u75c7\uff0c\u6b63\u5927\u5929\u6674\u7533\u62a5\u4e86\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u9002\u5e94\u75c7\u3002\u8fd9\u4e24\u5bb6\u516c\u53f8\u7684\u7533\u8bf7\u6709\u671b\u4e8e2018\u83b7\u6279\u4e0a\u5e02[1]\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;height: 42px !important;box-sizing: border-box !important;word-wrap: break-word !important;width: 215px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532683202.png\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;height: 40px !important;box-sizing: border-box !important;word-wrap: break-word !important;width: 160px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532683202.jpeg\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"height: 37px !important;box-sizing: border-box !important;word-wrap: break-word !important;width: 158px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532683203.png\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;letter-spacing: 0.5px;font-size: 32px;color: rgb(59, 179, 195);box-sizing: border-box !important;word-wrap: break-word !important;\">2<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(59, 179, 195);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(59, 179, 195);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5229\u59a5\u6614\u5355\u6297\u2014\u2014\u63a8\u51fa\u65b0\u5242\u578b<\/span><\/strong><\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7f8e\u7f57\u534e\uff08\u5229\u59a5\u6614\u5355\u6297\uff0cRituximab\uff09\u662f\u7f57\u6c0f\uff08Roche\uff09\u5f00\u53d1\u7684CD20\u5355\u6297\uff0c\u4e8e1997\u5e74\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u3001\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u3001\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff08RheumatoidArthritis\uff0cRA\uff09\u548c\u8840\u7ba1\u708e\uff08granulomatosis with polyangiitis\uff0cGPA\u548cmicroscopicpolyangiitis\uff0cMPA\uff09[11]\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;height: 260.712px !important;box-sizing: border-box !important;word-wrap: break-word !important;width: 630px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress2-1532683203.jpg\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7f8e\u7f57\u534e\u4f5c\u4e3a\u7f57\u6c0f\u7b2c\u4e00\u7545\u9500\u6297\u764c\u836f\uff0c\u6700\u8fd1\u4e09\u5e74\u4e00\u76f4\u4fdd\u6301\u5168\u7403\u9500\u552e\u989d70\u4ebf\u7f8e\u5143\u4ee5\u4e0a[12]\u2013[14]\u30022017\u5e74Celltrion\u7684Truxima\u548cSandoz\u7684Rixathon\u4e24\u6b3e\u7f8e\u7f57\u534e\u4eff\u5236\u836f\u5728\u6b27\u6d32\u4e0a\u5e02\uff0c\u4f7f\u5176\u6b27\u6d32\u9500\u552e\u989d\u5728\u5f53\u5e74\u4e0b\u964d\u4e8611%[12]\u3002Celltrion\u751a\u81f3\u9738\u6c14\u5730\u5ba3\u79f0\uff0c\u53bb\u5e744\u6708\u5f00\u59cb\u9500\u552e\u7684Truxima\u5230\u4e86\u53bb\u5e74\u7b2c\u56db\u5b63\u5ea6\u5c31\u5df2\u7ecf\u5728\u82f1\u56fd\u548c\u8377\u5170\u5360\u9886\u4e86\u8fd1\u534a\u6570\u5e02\u573a\u4efd\u989d\u3002<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;height: 378px !important;box-sizing: border-box !important;word-wrap: break-word !important;width: 630px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532683203.jpg\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><span style=\"max-width: 100%;letter-spacing: 1px;text-align: justify;font-size: 14px;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\">\uff08\u672c\u6587\u4e2d\u6c47\u73871\u7f8e\u5143=1\u745e\u58eb\u6cd5\u90ce\uff09<\/span><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">2018\u5e74\u7b2c\u4e00\u5b63\u5ea6\uff0c\u7f57\u6c0f\u7684\u7f8e\u7f57\u534e\u5728\u6b27\u6d32\u7684\u9500\u552e\u53c8\u5927\u5e45\u964d\u4f4e44%[15]\u3002Truxima\u4f5c\u4e3a\u4eff\u5236\u836f\uff0c\u5728\u552e\u4ef7\u4e0a\u6bd4\u7f8e\u7f57\u534e\u4f4e\u4e8630-40%\uff0c\u5e76\u4e14\u540c\u65f6\u4ee54\u4e2a\u4ea7\u54c1\u540d\u9488\u5bf9\u4e0d\u540c\u9002\u5e94\u75c7\u5728\u6b27\u6d32\u9500\u552e[16]\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6709\u5206\u6790\u8ba4\u4e3a\uff0c\u8fd9\u51e0\u4e2a\u4e0d\u540c\u7684\u4ea7\u54c1\u540d\u4f1a\u4ea7\u751f\u66f4\u6fc0\u70c8\u7684\u5e02\u573a\u7ade\u4ef7\uff0c\u6700\u7ec8\u4f7f\u5f97Celltrion\u7684\u603b\u5e02\u573a\u5360\u6bd4\u6700\u5927\u5316\u3002\u800c\u4e14Celltrion\u672a\u6765\u8fd8\u53ef\u4ee5\u628a\u8fd9\u4e9b\u4ea7\u54c1\u6388\u6743\u7ed9\u4e0d\u540c\u7684\u7ade\u4e89\u8005\uff0c\u5750\u6536\u6e14\u7fc1\u4e4b\u5229[17]\u3002\u5c31\u5728\u4eca\u5e744\u6708\u5e95\uff0cTruxima\u53c8\u83b7\u5f97\u4e86\u6fb3\u5927\u5229\u4e9a\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u9884\u671f\u5e74\u9500\u552e\u989d\u8fbe1\u4ebf\u7f8e\u5143[18]\u3002\u6b64\u5916\uff0c\u8f89\u745e\uff08Pfizer\uff09\u548c\u5b89\u8fdb\uff08Amgen\uff09\u4e5f\u5728\u51c6\u5907\u7f57\u7f8e\u534e\u4eff\u5236\u836f\u7684\u7533\u62a5[19], [20]\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u867d\u7136\u5982\u6b64\u731b\u70c8\u7684\u4eff\u5236\u836f\u653b\u52bf\u8ba9\u7f8e\u7f57\u534e\u7684\u524d\u666f\u770b\u8d77\u6765\u5e76\u4e0d\u4e50\u89c2\uff0c\u4f46\u4eff\u5236\u836f\u7684\u8def\u4e5f\u6ca1\u6709\u90a3\u4e48\u987a\u2014\u2014\u7f8e\u7f57\u534e\u5728\u7f8e\u56fd\u5e02\u573a\u7684\u589e\u957f\u52bf\u5934\u4f9d\u7136\u8fd8\u5728\uff0c2017\u5e74\u8fd8\u67096%\u7684\u589e\u957f[12]\u3002\u4eca\u5e744\u6708\u548c5\u6708\uff0cCelltrion\u548cSandoz\u53cc\u53cc\u6536\u5230FDA\u7684\u62d2\u4fe1\u3002FDA\u8003\u8651\u5230\u751f\u7269\u836f\u6210\u5206\u7684\u4e0d\u786e\u5b9a\u6027\uff0c\u4e0d\u80fd\u8d8a\u8fc7\u4e34\u5e8a\u8bd5\u9a8c\u901a\u8fc7\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\uff08bioequivalency\uff0cBE\uff09\u76f4\u63a5\u5f97\u5230\u6279\u51c6\uff0c\u6240\u4ee5\u751f\u7269\u836f\u5373\u4f7f\u662f\u4eff\u5236\u7684\uff0c\u4e5f\u4f9d\u7136\u9700\u8981\u505a\u6ee1\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u672c\u6765\u4fe1\u5fc3\u6ee1\u6ee1\u7684\u4e24\u5bb6\u516c\u53f8\u5df2\u7ecf\u51c6\u5907\u597d\u8981\u5728\u7f8e\u56fd\u5927\u5e72\u4e00\u573a\uff0c\u6ca1\u60f3\u5230\u4e34\u95e8\u4e00\u811a\u6253\u504f\u4e86\u65b9\u5411\uff0c\u4e09\u671f\u4e34\u5e8a\u56e0\u4e3a\u8bd5\u9a8c\u65b9\u6cd5\u4e0e\u539f\u7814\u836f\u4e0d\u7b26\u88abFDA\u5426\u51b3\u4e86\uff0c\u4f7f\u5f97\u4e0a\u5e02\u65f6\u95f4\u53c8\u8981\u63a8\u540e\u4e00\u6bb5\u65f6\u95f4[21],[22]\u3002<\/span><\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;height: 226.579px !important;box-sizing: border-box !important;word-wrap: break-word !important;width: 630px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532683203.jpg\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;height: 75.8612px !important;box-sizing: border-box !important;word-wrap: break-word !important;width: 630px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1532683203.jpg\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd9\u91cc\u987a\u4fbf\u63d0\u4e00\u53e5\uff0cCelltrion\u7684Truxima\u662f\u548c\u524d\u9762\u63d0\u5230\u7684Teva\u5728\u7f8e\u56fd\u8054\u5408\u5f00\u53d1\u7684\u3002\u6b64\u523bTeva\u7684\u9ad8\u7ba1\u53ef\u80fd\u6bd4Celltrion\u66f4\u7740\u6025\uff0c\u76fc\u7740Truxima\u80fd\u65e9\u70b9\u8865\u4e0aTreanda\u4eff\u5236\u836f\u4e0a\u5e02\u5e26\u6765\u7684\u51b2\u51fb\u3002<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cGlobalData\u7684\u533b\u751f\u91c7\u8bbf\u62a5\u544a\u663e\u793a\uff0c\u5f88\u591a\u53d7\u8bbf\u533b\u751f\u8003\u8651\u5230\u751f\u7269\u836f\u7684\u590d\u6742\u6027\uff0c\u5728\u6ca1\u6709\u957f\u671f\u4e34\u5e8a\u9a8c\u8bc1\u7ed3\u679c\u7684\u60c5\u51b5\u4e0b\uff0c\u4f9d\u7136\u504f\u5411\u7ed9\u65b0\u786e\u8bca\u7684\u75c5\u4eba\u4f7f\u7528\u539f\u7814\u836f\uff0c\u4eff\u5236\u836f\u66f4\u591a\u4f1a\u5f00\u7ed9\u590d\u53d1\u75c5\u4eba[16]\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e3a\u4e86\u5de9\u56fa\u81ea\u5df1\u5728\u7f8e\u56fd\u5e02\u573a\u7684\u5730\u4f4d\uff0c\u7f57\u6c0f\u5728\u53bb\u5e74\u8fd8\u83b7\u5f97\u4e86\u5229\u59a5\u6614\u5355\u6297\u65b0\u5242\u578b\u7684FDA\u6279\u51c6\uff0c\u6253\u7b97\u4ee5\u6b64\u5bf9\u6297\u4eff\u5236\u836f\u3002\u65b0\u5242\u578b\u4e2d\u6dfb\u52a0\u4e86\u900f\u660e\u8d28\u9178\u9176\uff0c\u5c06\u9759\u8109\u6ce8\u5c04\u53d8\u6210\u4e86\u76ae\u4e0b\u6ce8\u5c04\uff0c\u7ed9\u836f\u65f6\u957f\u4e5f\u4ece\u539f\u5242\u578b\u7684\u4e00\u4e2a\u534a\u5c0f\u65f6\u7f29\u77ed\u5230\u51e0\u5206\u949f[23]\u3002\u8fd9\u6837\u5c31\u51cf\u5c11\u4e86\u7ed9\u836f\u8fc7\u7a0b\u4e2d\uff0c\u533b\u62a4\u4eba\u5458\u7684\u770b\u62a4\u65f6\u95f4\uff0c\u8fd9\u5bf9\u4e8e\u5728\u533b\u9662\u91cc\u6d88\u8d39\u5206\u5206\u949f\u4e0a\u5929\u4ef7\u7684\u7f8e\u56fd\u5e02\u573a\u65e0\u7591\u53c8\u662f\u4e00\u5927\u4f18\u52bf\u3002\u5982\u6b64\u770b\u6765\uff0c\u7f57\u6c0f\u53ef\u8c13\u4e5f\u662f\u505a\u8db3\u4e86\u51c6\u5907\uff0c\u7b49\u7740Celltrion\u548cSandoz\u7684\u4eff\u5236\u836f\u4e0a\u5e02\uff0c\u548c\u4ed6\u4eec\u51b3\u4e00\u6b7b\u6218\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7f8e\u7f57\u534e\u4e8e2000\u5e74\u83b7\u5f97\u5f53\u65f6\u7684\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08State Food and Drug Administration\uff0cSFDA\uff09\u6279\u51c6\u5728\u56fd\u5185\u4e0a\u5e02\uff0c\u73b0\u5728\u7814\u5236\u76f8\u5e94\u4eff\u5236\u836f\u7684\u56fd\u5185\u836f\u4f01\u4e0d\u4e0b\u5341\u5bb6\uff0c\u5176\u4e2d\u4e0d\u4e4f\u590d\u5b8f\u6c49\u9716\u3001\u6b63\u5927\u5929\u6674\u8fd9\u6837\u80cc\u666f\u96c4\u539a\u7684\u4f01\u4e1a[24]\u30022017\u5e7412\u6708\u5e95\uff0c\u590d\u5b8f\u6c49\u9716\u5df2\u7ecf\u5c31\u5229\u59a5\u6614\u5355\u6297\u7533\u8bf7\u751f\u4ea7\u3002\u4eca\u5e741\u6708\uff0c\u590d\u5b8f\u6c49\u9716\u7684\u6bcd\u516c\u53f8\u590d\u661f\u53c8\u5ba3\u5e03\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u836f\u54c1\u8bc4\u5ba1\u4e2d\u5fc3\uff08Center for Drug Evaluation\uff0cCDE\uff09\u62df\u5c06\u5229\u59a5\u6614\u5355\u6297\u5217\u5165\u4f18\u5148\u8bc4\u5ba1\u3002\u4fe1\u8fbe\u751f\u7269\u3001\u795e\u5dde\u7ec6\u80de\u5de5\u7a0b\u4e5f\u6b63\u8fce\u5934\u8d76\u4e0a\uff0c\u8fdb\u5165III\u671f\u4e34\u5e8a\u8bd5\u9a8c[25]\u3002\u521a\u521a\u57282017\u5e74\u88ab\u7eb3\u5165\u533b\u4fdd\u540e\u5927\u5e45\u964d\u4ef7\u7684\u7f8e\u7f57\u534e\uff0c\u52bf\u5fc5\u53c8\u5c06\u5728\u4e2d\u56fd\u5e02\u573a\u53d7\u5230\u5de8\u5927\u7684\u6311\u6218\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;height: 251.699px !important;box-sizing: border-box !important;word-wrap: break-word !important;width: 630px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress2-1532683204.jpg\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;letter-spacing: 0.5px;font-size: 32px;color: rgb(59, 179, 195);box-sizing: border-box !important;word-wrap: break-word !important;\">3<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(59, 179, 195);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(59, 179, 195);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fbe\u6c99\u66ff\u5c3c\u2014\u2014\u4e13\u5229\u8bc9\u8bbc<\/span><\/strong><\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5982\u679c\u4f60\u770b\u5230\u8fd9\u4e2a\u836f\u540d\u65f6\uff0c\u7b2c\u4e00\u53cd\u5e94\u662f\u4e13\u5229\uff0c\u90a3\u4f60\u4e00\u5b9a\u662f\u4e00\u4f4d\u8001\u6c5f\u6e56\u3002\u6ca1\u9519\uff0c4\u5e74\u524d\u6b63\u5927\u5929\u6674\u548c\u5317\u4eac\u53cc\u9e6d\u6b63\u662f\u4e3a\u4e86\u8fd9\u4e2a\u65bd\u8d35\u5b9d\uff08Bristol-MyersSquibb\uff09\u7684\u539f\u7814\u6297\u764c\u836f\u2014\u2014\u65bd\u8fbe\u8d5b\uff08\u8fbe\u6c99\u66ff\u5c3c\uff0cDasatinib\uff09\uff0c\u5435\u5f97\u4e0d\u53ef\u5f00\u4ea4[26]\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;height: 106.015px !important;box-sizing: border-box !important;word-wrap: break-word !important;width: 630px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532683204.jpg\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u65bd\u8fbe\u8d5b\u5728\u4e2d\u56fd\u7684\u4e13\u5229\u53ea\u7533\u8bf7\u4fdd\u62a4\u4e86\u8fbe\u6c99\u66ff\u5c3c\u4e00\u6c34\u5316\u5408\u7269\u7684\u6676\u578b\uff0c\u800c\u6b63\u5927\u5929\u6674\u5c31\u94bb\u4e86\u8fd9\u4e2a\u7a7a\u5b50\uff0c\u4ee5\u65e0\u6c34\u5316\u5408\u7269\u7684\u6676\u578b\uff0c\u7ed5\u5f00\u4e13\u5229\u4fdd\u62a4\uff0c\u706b\u901f\u63d0\u4ea4\u4e86\u4e0a\u5e02\u7533\u8bf7\u3002\u773c\u770b\u9996\u4eff\u836f\u7684\u5e02\u573a\u5c31\u8981\u88ab\u6b63\u5927\u5929\u6674\u62a2\u8d70\u4e86\uff0c\u5317\u4eac\u53cc\u9e6d\u4f5c\u4e3a\u51e0\u4e4e\u540c\u65f6\u9012\u4ea4\u8fbe\u6c99\u66ff\u5c3c\u4eff\u5236\u836f\u4e34\u5e8a\u7533\u8bf7\u7684\u516c\u53f8\uff0c\u611f\u5230\u6781\u4e3a\u5fff\u5fff\u4e0d\u5e73\u3002\u90a3\u65f6\u65bd\u8fbe\u8d5b\u5728\u4e2d\u56fd\u7684\u4e13\u5229\u8fd8\u672a\u5230\u671f\uff0c\u4e8e\u662f\u4e00\u573a\u9488\u5bf9\u6b63\u5927\u5929\u6674\u5bf9\u4e8e\u6b64\u6676\u578b\u4e13\u5229\uff0c\u662f\u5426\u6784\u6210\u4fb5\u6743\u7684\u8206\u8bba\u6218\u5439\u54cd\u4e86\u53f7\u89d2\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e0d\u8fc7\uff0c\u8fd9\u4ef6\u4e8b\u4e5f\u53ea\u80fd\u505c\u7559\u5728\u8206\u8bba\u6218\u5c42\u9762\u4e86\uff0c\u6bd5\u7adf\u65bd\u8d35\u5b9d\u4f5c\u4e3a\u539f\u7814\u836f\u5382\u65b9\u90fd\u6ca1\u6709\u8bf4\u6b63\u5927\u5929\u6674\u4fb5\u6743\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">2013\u5e749\u6708\u6b63\u5927\u5929\u6674\u7684\u4f9d\u5c3c\u8212\uff08\u8fbe\u6c99\u66ff\u5c3c\u7247\uff09\u5c31\u5df2\u7ecf\u83b7\u6279\u5e76\u4e0a\u5e02\u9500\u552e\uff0c\u800c\u5317\u4eac\u53cc\u9e6d\u7684\u8fbe\u6c99\u66ff\u5c3c\u2026\u2026\u73b0\u5728\u90fd\u8fd8\u6ca1\u6279\u51c6\u751f\u4ea7\u3002\u6b64\u65f6\u4f60\u4f1a\u4e0d\u4f1a\u597d\u5947\uff0c\u65bd\u8d35\u5b9d\u5f53\u65f6\u4e3a\u4ec0\u4e48\u6ca1\u6709\u884c\u52a8\u5462\uff1f\u867d\u7136\u4ed6\u4eec\u786e\u5b9e\u6ca1\u6709\u5728\u4e2d\u56fd\u7533\u8bf7\u65e0\u6c34\u6676\u578b\u7684\u4e13\u5229\uff0c\u4f46\u662f\u96be\u9053\u7518\u5fc3\u5c31\u8fd9\u6837\u5c06\u5784\u65ad\u5e02\u573a\u62f1\u624b\u76f8\u8ba9\u5417\uff1f<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5176\u5b9e\uff0c\u5c31\u5728\u51e0\u4e4e\u76f8\u540c\u7684\u65f6\u95f4\uff0c\u65bd\u8d35\u5b9d\u6b63\u4e3a\u4e86\u65bd\u8fbe\u8d5b\u548c\u52a0\u62ff\u5927\u4eff\u5236\u836f\u516c\u53f8Apotex\u4e89\u593a\u6b27\u6d32\u3001\u7f8e\u56fd\u3001\u52a0\u62ff\u5927\u4e09\u5730\u7684\u4e13\u5229\u6743\u2014\u2014\u53ef\u80fd\u662f\u5fc3\u592a\u7d2f\uff0c\u771f\u7684\u987e\u4e0d\u8fc7\u6765\u5427\u3002\u6253\u5b98\u53f8\u5012\u662f\u6ca1\u4ec0\u4e48\uff0c\u8de8\u56fd\u533b\u836f\u516c\u53f8\u5bf9\u8fd9\u5957\u60f3\u5fc5\u662f\u8f7b\u8f66\u719f\u8def\uff0c\u53ef\u662f\u6ca1\u60f3\u5230\u8fd9\u5b98\u53f8\u4e00\u6253\u5c31\u662f4\u5e74\u3002<\/span><\/p>\n<p style=\"margin-right: 48px;margin-left: 48px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;height: 123px !important;box-sizing: border-box !important;word-wrap: break-word !important;width: 410px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress7-1532683204.png\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fc7\u7a0b\u4e0d\u518d\u8d58\u8ff0\uff0c\u7ed3\u679c\u5c31\u662f\u8fd9\u4e00\u5207\u7ec8\u4e8e\u57282017\u5e74\u5c18\u57c3\u843d\u5b9a\uff0c\u65bd\u8d35\u5b9d\u8f93\u4e86\u6b27\u6d32[27]\uff0c\u8d62\u4e86\u52a0\u62ff\u5927[28]\uff0c\u5728\u7f8e\u56fd\u548c\u89e3[29]\u3002\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\uff0cApotex\u8fd8\u8d81\u70ed\u6253\u94c1\uff0c\u987a\u5e26\u62ff\u5230\u4e86\u7f8e\u56fd\u7684\u9996\u4e2a\u4eff\u5236\u836f\u6279\u51c6\u4e0a\u5e02\u3002\u7136\u800c\u6839\u636e\u53cc\u65b9\u5728\u7f8e\u56fd\u5e02\u573a\u7684\u548c\u89e3\u7ea6\u5b9a\uff0cApotex\u7684\u4eff\u5236\u836f\u867d\u7136\u62ff\u5230\u4e86\u4e0a\u5e02\u8bb8\u53ef\uff0c\u8fd8\u662f\u8981\u7b49\u52302024\u5e749\u6708\u4efd\u624d\u80fd\u5f00\u59cb\u9500\u552e\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8bb2\u5230\u8fd9\u91cc\uff0c\u4f60\u53ef\u80fd\u597d\u5947\uff0c\u8fd9\u4e2a\u8ba9\u5404\u4e2a\u516c\u53f8\u4e3a\u4e4b\u4e89\u8bba\u4e0d\u4f11\u7684\u836f\uff0c\u7a76\u7adf\u662f\u4ec0\u4e48\u6765\u5934\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u65bd\u8fbe\u8d5b\u4e8e2006\u5e74\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\uff0c\u6700\u521d\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\uff08CML\uff09\u540e\u6765\u6269\u5c55\u5230\u513f\u7ae5\u7528\u836f[30]\u3002\u8be5\u836f\u4e00\u7ecf\u4e0a\u5e02\u9500\u552e\u989d\u4fbf\u52bf\u5982\u7834\u7af9\uff0c\u8fd9\u4e2a\u66fe\u7ecf\u201c\u5168\u7403\u6700\u8d35\u7684\u6297\u764c\u836f\u201d\u5341\u5e74\u6765\u51e0\u4e4e\u6ca1\u6709\u4f4e\u4e8e10%\u7684\u5e74\u589e\u957f\u7387\uff0c2017\u5e74\u7684\u5168\u7403\u9500\u552e\u989d\u5df2\u8d85\u8fc720\u4ebf\u7f8e\u5143[29]\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532683204.jpg\" alt=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\" title=\"\u770b\u4e0d\u89c1\u7684\u6218\u4e89\uff1a\u539f\u7814\u836f vs \u4eff\u5236\u836f | \u767d\u8840\u75c5\u7bc7\"  \/><\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7136\u800c\uff0c\u5b83\u8fdb\u5165\u4e2d\u56fd\u7684\u8def\u5374\u5e76\u4e0d\u987a\u5229\u3002\u7ecf\u8fc7\u4e0a\u9762\u6240\u8ff0\u7684\u4eff\u5236\u836f\u98ce\u6ce2\uff0c\u6b63\u5927\u5929\u6674\u7684\u4f9d\u5c3c\u8212\uff08\u8fbe\u6c99\u66ff\u5c3c\uff09\u5f97\u4ee5\u75281\/8\u7684\u65bd\u8fbe\u8d5b\u539f\u4ef7\u9500\u552e\u3002\u867d\u7136\u7b97\u4e0a\u65bd\u8fbe\u8d5b\u901a\u8fc7\u63f4\u52a9\u9879\u76ee\u7ed9\u7684\u6298\u6263\uff0c\u6b63\u5927\u5929\u6674\u7684\u4ef7\u683c\u5176\u5b9e\u662f\u65bd\u8fbe\u8d5b\u7684\u4e00\u534a\uff0c\u4f46\u663e\u7136\u65bd\u8fbe\u8d5b\u5728\u8425\u9500\u8fc7\u7a0b\u4e2d\u5403\u4e8f\u5f88\u591a\u30022017\u5e74\uff0c\u65bd\u8fbe\u8d5b\u88ab\u7eb3\u5165\u6211\u56fd\u533b\u4fdd\uff0c\u7d27\u63a5\u7740\u4fbf\u964d\u4ef7\u5927\u534a[31]\u3002\u672a\u6765\u7684\u9053\u8def\u662f\u660e\u662f\u6697\uff0c\u5bf9\u4e8e\u65bd\u8fbe\u8d5b\u6765\u8bf4\u8fd8\u662f\u4e00\u4e2a\u672a\u89e3\u7684\u8c1c\u9898\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<h2 style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/h2>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;letter-spacing: 0.5px;font-size: 32px;color: rgb(59, 179, 195);box-sizing: border-box !important;word-wrap: break-word !important;\">4<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(59, 179, 195);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(59, 179, 195);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7ed3\u8bed<\/span><\/strong><\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e2d\u56fd\u4f5c\u4e3a\u5168\u7403\u7b2c\u4e8c\u5927\u7ecf\u6d4e\u4f53\uff0c\u6297\u764c\u836f\u7684\u5e02\u573a\u6f5c\u529b\u5de8\u5927\uff0c\u767d\u8840\u75c5\u53c8\u662f\u5176\u4e2d\u4e0d\u53ef\u5ffd\u89c6\u7684\u4e00\u5458\uff0c\u6bcf\u4e00\u4e2a\u5728\u8fd9\u4e00\u884c\u7684\u4eba\u4e5f\u90fd\u60f3\u529e\u6cd5\u8d81\u70ed\u5206\u4e00\u676f\u7fb9\u3002\u867d\u8bf4\u4e0a\u5e02\u4ea7\u54c1\u6570\u4e0d\u80dc\u6570\uff0c\u4f46\u6bcf\u4e00\u4e2a\u836f\u7684\u80cc\u540e\u90fd\u6709\u5b83\u7684\u77db\u76fe\u548c\u8270\u8f9b\u3002\u73b0\u5728\uff0c\u5f53\u4f60\u770b\u5b8c\u8fd9\u4e09\u4e2a\u6545\u4e8b\uff0c\u662f\u4e0d\u662f\u89c9\u5f97\u7fb9\u8fd8\u6ca1\u62ff\u5230\u624b\uff0c\u5c31\u88ab\u70eb\u4e86\u4e00\u4e0b\uff1f<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(59, 179, 195);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5e76\u8d2d\u7ade\u4e89\u5bf9\u624b\u8981\u8861\u91cf\u4ef7\u683c\u662f\u5426\u5408\u9002\uff1b\u7533\u8bf7\u9996\u4eff\u8981\u5c3d\u4e00\u5207\u53ef\u80fd\u62a2\u5360\u5148\u673a\uff1b\u4e13\u5229\u8bc9\u8bbc\u8fd8\u8981\u719f\u77e5\u5404\u56fd\u6cd5\u5f8b\u6cd5\u89c4\u2026\u2026<\/span><\/strong><\/span><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd9\u4e9b\u53ea\u662f\u4f17\u591a\u4e89\u6597\u624b\u6bb5\u4e2d\u7684\u51b0\u5c71\u4e00\u89d2\uff0c\u8d8a\u662f\u6d3b\u8dc3\u5f00\u653e\u7684\u5e02\u573a\u4e5f\u8d8a\u662f\u7ade\u4e89\u6fc0\u70c8\u3002\u539f\u7814\u836f\u5382\u5546\u9762\u5bf9\u4eff\u5236\u836f\u7684\u7ade\u4e89\uff0c\u6839\u636e\u5404\u81ea\u7684\u5b9e\u529b\u548c\u60c5\u666f\u53c8\u6709\u4e0d\u540c\u7684\u7b56\u7565\u3002\u6709\u7684\u4e3a\u4e86\u4fdd\u4f4f\u9500\u552e\u4e1a\u7ee9\uff0c\u62fc\u547d\u5b88\u4f4f\u5df2\u6709\u7684\u9635\u5730\uff1b\u6709\u7684\u5219\u65e9\u5df2\u53e6\u6709\u65b0\u6b22\uff0c\u6cf0\u7136\u5904\u4e4b\uff0c\u63a5\u6536\u5e02\u573a\u89c4\u5f8b\u3002<\/span><\/p>\n<p style=\"margin-top: 25px;margin-bottom: 25px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u867d\u7136\u76ee\u524d\u6211\u56fd\u7684\u836f\u4f01\u4ea7\u54c1\u7ebf\u8fd8\u662f\u4ee5\u4eff\u5236\u836f\u4e3a\u4e3b\uff0c\u4f46\u662f\u56fd\u5bb6\u540c\u65f6\u5927\u529b\u53d1\u5c55\u521b\u65b0\u836f\u7684\u8d8b\u52bf\u5df2\u7ecf\u65e5\u6e10\u660e\u663e\u3002<\/span><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;color: rgb(59, 179, 195);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u539f\u7814\u836f\u548c\u4eff\u5236\u836f\u7684\u76f4\u63a5\u5bf9\u6297\uff0c\u7ec8\u6709\u4e00\u5929\u4e0d\u53ef\u907f\u514d\u3002<\/strong><\/span><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8eab\u5904\u5176\u4e2d\u7684\u4e2d\u56fd\u836f\u4f01\uff0c\u8fd8\u5e94\u5f53\u63d0\u65e9\u505a\u597d\u4ea7\u54c1\u751f\u547d\u5468\u671f\u7684\u89c4\u5212\u548c\u5b9a\u4f4d\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"color: rgb(255, 0, 0);\"><strong>\u5f80\u671f\u7cbe\u5f69<\/strong><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"color: rgb(255, 0, 0);text-decoration: underline;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231167&amp;idx=1&amp;sn=28235cb4fd7bb283cf83af16cc7d3a42&amp;chksm=84be7824b3c9f132888169756d6229bda5f6942392c2d5adf0678a7bd053afa3b48bf35d379d&amp;scene=21#wechat_redirect\" target=\"_blank\">\u4e00\u81f4\u6027\u8bc4\u4ef7\u76843\u5bb6\u4e0e3\u5e74<\/a><strong><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231167&amp;idx=1&amp;sn=28235cb4fd7bb283cf83af16cc7d3a42&amp;chksm=84be7824b3c9f132888169756d6229bda5f6942392c2d5adf0678a7bd053afa3b48bf35d379d&amp;scene=21#wechat_redirect\" target=\"_blank\"><\/a><br  \/><\/strong><\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"color: rgb(255, 0, 0);text-decoration: underline;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652230701&amp;idx=1&amp;sn=ea702ea398a915207c0901323d96697a&amp;chksm=84be79f6b3c9f0e08013a45f74ccb18f77b2470d83a0b6a500591ffc2970fa796b24166bd325&amp;scene=21#wechat_redirect\" target=\"_blank\">\u6c47\u805a\u5357\u836f\u7275\u7ebf\u642d\u6865 &nbsp;\u6821\u4f01\u643a\u624b\u5171\u540c\u63a2\u7d22\u4eba\u624d\u57f9\u517b\u65b0\u6a21\u5f0f\u4e00\u4e00\u9996\u5c4aCRA\u4eba\u624d\u57f9\u8bad\u73ed\u7eaa\u5b9e<\/a><br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231162&amp;idx=1&amp;sn=7b4cf87e991464cf2205db0c1293d26f&amp;chksm=84be7821b3c9f13739102fa0302f2743f323e9c92658af76d99cd548cb37cba12cd3c96b1193&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;\">\u540c\u5fc3\u7b51\u68a6\u2014\u2014\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u4e0a\u6d77\u6821\u53cb\u4f1a\u5e74\u4f1a\u4fa7\u8bb0<\/a><br  \/><\/p>\n<p style=\"white-space: normal;\">\n<p><br  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u6c47\u805a\u5357\u836f                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u968f\u7740\u56fd\u5bb6\u4e0d\u65ad\u5bf9\u5916\u5f00\u653e\u8fdb\u53e3\u521b\u65b0\u6297\u764c\u836f\u7684\u5e02\u573a\uff0c\u56fd\u5185\u7684\u60a3\u8005\u53ef\u4ee5\u5f97\u5230\u66f4\u5feb\u901f\u66f4\u6709\u6548\u7684\u6cbb\u7597\u3002\u8fd9\u4e00\u653f\u7b56\u5728\u5e26\u6765\u516c\u5171\u5065\u5eb7\u798f\u7949\u7684\u540c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6982,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/6981"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=6981"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/6981\/revisions"}],"predecessor-version":[{"id":7000,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/6981\/revisions\/7000"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/6982"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=6981"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=6981"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=6981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}