{"id":70694,"date":"2018-10-03T01:00:00","date_gmt":"2018-12-07T04:47:08","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/7612ba0a78\/"},"modified":"2018-12-07T12:47:11","modified_gmt":"2018-12-07T04:47:11","slug":"7612ba0a78","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/70694\/","title":{"rendered":"\u4e89\u8bba | \u5173\u4e8e\u9648\u5217\u5e73\u6559\u6388\u8be5\u4e0d\u8be5\u83b7\u5956\u7684\u8bc4\u8bba"},"content":{"rendered":"
\n

\"\u4e89\u8bba<\/p>\n

\"\u4e89\u8bba<\/p>\n

2018\u5e74\u8bfa\u5956\u6388\u4e88Allison\u548cHonjo\uff0c\u5f15\u540c\u884c\u70ed\u8bae<\/span><\/p>\n

\u64b0\u6587 | \u53f6\u6c34\u9001<\/strong><\/p>\n

\u6765\u6e90 | \u77e5\u8bc6\u5206\u5b50\uff08The-Intellectual\uff09<\/span><\/span><\/strong><\/p>\n

 <\/p>\n

\u25cf<\/span> <\/span><\/span>\u25cf<\/span> <\/span><\/span>\u25cf<\/span><\/p>\n


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2018\u5e7410\u67081\u65e5\u6b63\u503c\u56fd\u5e86\u9ec4\u91d1\u5468\uff0c\u8bfa\u5956\u5468\u4e5f\u968f\u4e4b\u5f00\u542f\u3002\u6765\u81ea\u745e\u5178\u65af\u5fb7\u54e5\u5c14\u6469\u7684\u7535\u8bdd\u58f0\u6ca1\u6709\u7ed9\u6211\u4eec\u5e26\u6765\u60ca\u559c\uff0c\u53cd\u5012\u662f\u6270\u4e71\u4e86\u5f88\u591a\u4eba\u5728\u9ec4\u91d1\u5468\u5e94\u6709\u7684\u8282\u594f\uff0c\u4ed6\u4eec\u6ca1\u6709\u5728\u65c5\u9014\u4e2d\u4eab\u53d7\u7f8e\u666f\uff0c\u6216\u5728\u670b\u53cb\u5708\u6652\u98ce\u666f\u7167\uff0c\u800c\u662f\u5bf9\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u6216\u533b\u5b66\u5956\u8fdb\u884c\u8bc4\u70b9\uff0c\u4e2d\u95f4\u4e0d\u4e4f\u5939\u6742\u7740\u4e9b\u8bb8\u9057\u61be\uff0c\u751a\u81f3\u662f\u5931\u843d\u3002<\/p>\n

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\u5f88\u591a\u4eba\u8ba4\u4e3a\u4eca\u5e74\u7684\u8bfa\u5956\u5e76\u4e0d\u516c\u6b63\uff0c\u5e76\u4e3a\u534e\u4eba\u5b66\u8005\u3001\u8036\u9c81\u5927\u5b66\u6559\u6388\u9648\u5217\u5e73\u6ca1\u80fd\u83b7\u5956\u800c\u611f\u5230\u4e0d\u5e73\u3002Nature<\/em>\u6742\u5fd7\u3001\u77e5\u540d\u5a92\u4f53STAT\u4e5f\u5728\u7b2c\u4e00\u65f6\u95f4\u5173\u6ce8\u4e86\u8fd9\u4e00\u4e8b\u4ef6\uff0c\u7f57\u5217\u51fa\u4e0d\u540c\u5b66\u8005\u7684\u770b\u6cd5\u3002\u7a76\u7adf\u4eca\u5e74\u7684\u8bfa\u5956\u662f\u5426\u516c\u5e73\uff0c\u9996\u5148\u5148\u56de\u987e\u4e00\u4e0b\u80bf\u7624\u514d\u75ab\u9886\u57df\u7684\u53d1\u5c55\u6982\u8981\u3002<\/p>\n

 <\/p>\n

\u80bf\u7624\u514d\u75ab\u9886\u57df\u7b80\u8981\u56de\u987e<\/strong><\/span><\/p>\n

 <\/p>\n

\"\u4e89\u8bba<\/p>\n


<\/p>\n

\u6765\u81ea\u7f8e\u56fd\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u7684\u8a79\u59c6\u65af\u00b7\u827e\u91cc\u68ee\uff08James Allison\uff09\u548c\u65e5\u672c\u4eac\u90fd\u5927\u5b66\u7684\u672c\u5eb6\u4f51\uff08Tasuku Honjo\uff09\uff0c\u56e0\u201c\u901a\u8fc7\u6291\u5236\u514d\u75ab\u8d1f\u8c03\u8282\u673a\u5236\uff0c\u53d1\u73b0\u4e86\u65b0\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\u201d\u83b7\u5f97\u4e86\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u6216\u533b\u5b66\u5956\u3002<\/p>\n

 <\/p>\n

\u80bf\u7624\u662f\u4eba\u7c7b\u7684\u987d\u75be\uff0c\u6bcf\u5e74\u5168\u7403\u65b0\u589e1800\u4e07\u80bf\u7624\u60a3\u8005\uff0c\u53e6\u6709960\u4e07\u4eba\u56e0\u80bf\u7624\u6b7b\u4ea1\uff0c\u56e0\u6b64\u6709\u4eba\u5c06\u80bf\u7624\u89c6\u4e3a\u201c\u4f17\u75c5\u4e4b\u738b\u201d\u3002\u4e2d\u56fd\u4e5f\u662f\u764c\u75c7\u8d1f\u62c5\u6c89\u91cd\u7684\u5927\u56fd\u3002<\/p>\n

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\u81ea\u767e\u65f6\u7f8e\u8d35\u5b9d\u548c\u9ed8\u514b\u5148\u540e\u5f00\u53d1\u51fa\u4e86\u57fa\u4e8e\u514d\u75ab\u68c0\u67e5\u70b9\u7684\u91cd\u78c5\u836f\u7269Opdivo\u548cKeytruda\u540e\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u60a3\u8005\u53d7\u76ca\u80bf\u7624\u514d\u75ab\u836f\u7269\u3002\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u88ab\u89c6\u4e3a\u81ea\u653e\u7597\u3001\u5316\u7597\u4ee5\u53ca\u9776\u5411\u6cbb\u7597\u540e\uff0c\u764c\u75c7\u6cbb\u7597\u7684\u53c8\u4e00\u4e2a\u7a81\u7834\u3002<\/p>\n

 <\/p>\n

\u80bf\u7624\u514d\u75ab\u4e4b\u6240\u4ee5\u5728\u5982\u6b64\u77ed\u7684\u65f6\u95f4\u5185\u88ab\u5e7f\u6cdb\u8ba4\u53ef\uff0c\u8fd9\u5f97\u76ca\u4e8e\u65e0\u6570\u79d1\u5b66\u5bb6\u5728\u8fc7\u53bb\u6570\u5341\u5e74\u91cc\u524d\u8d74\u540e\u7ee7\u7684\u52aa\u529b\u3002\u6b64\u6b21\u83b7\u5f97\u8bfa\u5956\u7684Allison\u548cHonjo\u662f\u8fd9\u4e00\u9886\u57df\u7684\u6770\u51fa\u4ee3\u8868\uff0c\u4ed6\u4eec\u5206\u522b\u53d1\u73b0\u963b\u65adCTLA-4\u901a\u8def\uff0c\u6062\u590d\u514d\u75ab\u7ec6\u80de\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\uff0c\u4ee5\u53ca\u53d1\u73b0PD-1\u5206\u5b50\uff0c\u5e76\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0c\u53d1\u73b0\u963b\u65adPD-1\u901a\u8def\u53ef\u89e3\u9664\u514d\u75ab\u7ec6\u80de\u7684\u6291\u5236\u4f5c\u7528\uff0c\u6062\u590d\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u3002<\/p>\n

 <\/p>\n

\u9664\u6b64\u4e4b\u5916\uff0c\u8fd8\u6709\u6570\u4f4d\u5728\u8fd9\u4e00\u9886\u57df\u7684\u5173\u952e\u6027\u7a81\u7834\u505a\u51fa\u91cd\u8981\u8d21\u732e\u7684\u79d1\u5b66\u5bb6\uff0c\u5982\u8036\u9c81\u5927\u5b66\u6559\u6388\u9648\u5217\u5e73\u3001\u4e39\u7eb3\u2022\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\u7684Freeman\u7b49\u3002\u6b64\u524d\u6211\u4eec\u4e5f\u4ecb\u7ecd\u4e86\u9648\u5217\u5e73\u6559\u6388\u7684\u5de5\u4f5c\uff0c\u9648\u5217\u5e73\u6559\u6388\u5bf9\u80bf\u7624\u514d\u75ab\u7684\u89c1\u89e3\u4e5f\u7f57\u5217\u5728\u6587\u4e2d\uff0c\u8be6\u60c5\u8bf7\u89c1\u6587\u672b\u5217\u8868\u3002\u4e3a\u4f55\u4ed6\u6ca1\u6709\u83b7\u5f97\u8bfa\u5956\uff1f\u5982\u4e0b\u7f57\u5217\u51fa\u4e0d\u540c\u5b66\u8005\u5bf9\u8fd9\u4e00\u95ee\u9898\u7684\u770b\u6cd5\u548c\u89c2\u70b9\u3002<\/p>\n

 <\/p>\n

\u5bf9\u8bfa\u8d1d\u5c14\u751f\u7406\u6216\u533b\u5b66\u5956\u7684\u770b\u6cd5<\/strong><\/span><\/p>\n


<\/strong><\/span><\/p>\n

\"\u4e89\u8bba<\/p>\n

Allison\u7684\u4fdd\u65f6\u6377911\uff0c\u8f66\u724c\u53f7 \u4e3aCTLA-4<\/span><\/p>\n

 <\/p>\n

James Allison\uff1a<\/strong>\u80fd\u83b7\u5f97\u5982\u6b64\u6b8a\u8363\u6211\u611f\u5230\u975e\u5e38\u8363\u5e78\uff0c\u6211\u662f\u4e00\u540d\u57fa\u7840\u7814\u7a76\u9886\u57df\u7684\u79d1\u5b66\u5bb6\uff0c\u901a\u8fc7\u6211\u7684\u5de5\u4f5c\u7684\u786e\u5f71\u54cd\u529b\u5f88\u591a\u4eba\uff0c\u6211\u8ba4\u4e3a\u8fd9\u662f\u6700\u7f8e\u5999\u7684\u4e8b\u60c5\u4e4b\u4e00\u3002\u5b83\u4e5f\u662f\u6bcf\u4e2a\u4eba\u7684\u68a6\u60f3\u3002<\/p>\n


<\/p>\n

 \"\u4e89\u8bba<\/p>\n


<\/p>\n


<\/p>\n

Tasuku Honjo\uff1a<\/strong> <\/span>\u5bf9\u4e8e\u83b7\u5f97\u8fd9\u4e00\u91cd\u8981\u5956\u9879\u6211\u611f\u5230\u5f88\u8363\u5e78\u30021992\u5e74\uff0c\u6211\u53d1\u73b0\u4e86PD-1\uff0c\u6211\u4eec\u7684\u57fa\u7840\u7814\u7a76\u8ba9\u540e\u7eed\u7684\u4e34\u5e8a\u5e94\u7528\u6210\u4e3a\u53ef\u80fd\uff0c\u5b83\u5e2e\u52a9\u4e86\u8bb8\u591a\u75c5\u60a3\u3002\u5f53\u6211\u88ab\u5eb7\u590d\u7684\u60a3\u8005\u611f\u6fc0\u65f6\uff0c\u6211\u771f\u6b63\u5730\u611f\u5230\u6211\u4eec\u7814\u7a76\u7684\u91cd\u8981\u6027\u3002<\/p>\n

 <\/p>\n

\u9648\u5217\u5e73\uff1a<\/strong>\u6211\u4eec\u90fd\u89c9\u5f97\u8fd9\u6b21\u53d1\u5956\u7684\u903b\u8f91\u6df7\u4e71\uff0c\u9996\u5148CTLA-4\u5e76\u4e0d\u662f\u8a79\u59c6\u65af-\u827e\u5229\u68ee\u53d1\u73b0\u7684\uff0c\u800c\u662f\u6cd5\u56fd\u4ebaP Goldstein\u53d1\u73b0\u7684\uff0c\u800cCTLA-4\u7684\u6291\u5236\u4f5c\u7528\u4e5f\u662f\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\uff08UCSF\uff09\u7684\u514d\u75ab\u5b66\u5bb6\u3001Parker\u764c\u75c7\u6cbb\u7597\u7814\u7a76\u6240\uff08Parker Institute for CancerImmunotherapy\uff09CEO Jeff Bluestone\u53d1\u73b0\u7684\uff0c\u827e\u5229\u68ee\u53ea\u662f\u9996\u6b21\u5c06\u5176\u4f5c\u7528\u8054\u5230\u764c\u75c7\u6cbb\u7597\u65b9\u9762\uff0c\u8fd9\u662f\u4ed6\u7684\u8d21\u732e\u3002\u800c\u672c\u5eb6\u4f51\u867d\u7136\u53d1\u73b0\u4e86PD-1\uff0c\u4f46\u662f\u673a\u5236\u5e76\u4e0d\u662f\u4ed6\u53d1\u73b0\u7684\uff0c\u80bf\u7624\u6cbb\u7597\u66f4\u662f\u4e0e\u4ed6\u65e0\u5173\u3002\u4f46\u8fd9\u4e24\u4f4d\u5728\u5ba3\u4f20\u9f13\u52a8\u65b9\u9762\u786e\u5b9e\u80dc\u51fa\u6211\u5f88\u591a\u3002\u6240\u4ee5\u6211\u8ba4\u4e3a\uff0c\u5bf9\u5de5\u4f5c\u7684\u5ba3\u4f20\u8981\u6bd4\u5de5\u4f5c\u672c\u8eab\u91cd\u8981\u5f88\u591a\u3002<\/p>\n

 <\/p>\n

Freeman\uff1a<\/strong>\u6211\u4e3a\u81ea\u5df1\u7684\u8d21\u732e\u88ab\u5ffd\u7565\u611f\u5230\u5931\u671b\u3002\u7f8e\u56fd\u80bf\u7624\u7814\u7a76\u6240\u548cAlpert\u57fa\u91d1\u4f1a\u56e0PD-1\/PD-L1\u5c06\u5956\u9879\u9881\u53d1\u7ed9Honjo\u3001Freeman\u3001Sharpe\u548cLiepingChen\u624d\u662f\u6b63\u786e\u7684\u3002<\/p>\n

 <\/p>\n

\u540c\u884c\u5b66\u8005\u5bf9\u4eca\u5e74\u751f\u7406\u6216\u533b\u5b66\u5956\u7684\u8bc4\u4ef7<\/strong><\/span><\/p>\n

 <\/p>\n

\u66f9\u96ea\u6d9b\uff08\u5357\u5f00\u5927\u5b66\u6821\u957f\uff09<\/strong>\uff1a \u6211\u4ece\u5fc3\u91cc\u771f\u8bda\u5730\u8868\u8fbe\u5bf9\u8036\u9c81\u5927\u5b66\u534e\u4eba\u514d\u75ab\u5b66\u5bb6\u9648\u5217\u5e73\u6559\u6388\uff08\u798f\u5efa\u533b\u79d1\u5927\u5b66\u6bd5\u4e1a\uff0c\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\u7855\u58eb\u6bd5\u4e1a\uff09\u548c\u52a0\u62ff\u5927\u591a\u4f26\u591a\u5927\u5b66\u534e\u4eba\u514d\u75ab\u5b66\u5bb6Tak Mak\u6559\u6388\uff08\u51fa\u751f\u4e8e\u9999\u6e2f\uff09\u7684\u656c\u91cd\u3002\u9648\u5217\u5e73\u6559\u6388\u5728PD-L1(\u53c8\u79f0B7-H1)\u7684\u53d1\u73b0\u5e76\u5e94\u7528\u4e8e\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u6770\u51fa\u8d21\u732e\uff0c\u5f97\u5230\u4e86\u56fd\u9645\u514d\u75ab\u5b66\u754c\u548c\u80bf\u7624\u5b66\u754c\u7684\u516c\u8ba4\uff0cTakMak\u6559\u6388\u56e0\u72ec\u7acb\u53d1\u73b0CTLA-4\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u5e76\u7387\u5148\u53d1\u73b0\u5c0f\u9f20T\u7ec6\u80de\u53d7\u4f53\u7b49\u4e00\u7cfb\u5217\u91cd\u5927\u57fa\u7840\u6027\u6210\u679c\u800c\u4eab\u8a89\u56fd\u9645\u514d\u75ab\u5b66\u754c\u3002\u5f88\u60cb\u60dc\u4ed6\u4eec\u672a\u83b7\u5f97\u4eca\u5e74\u7684\u8bfa\u5956\uff0c\u4f46\u76f8\u4fe1\u4ed6\u4eec\u4f5c\u4e3a\u56fd\u9645\u4e00\u6d41\u751f\u7269\u533b\u5b66\u5bb6\uff0c\u5bf9\u4eba\u7c7b\u5065\u5eb7\u6240\u505a\u51fa\u7684\u5b9e\u5b9e\u5728\u5728\u7684\u8d21\u732e\uff0c\u5c06\u6c38\u8fdc\u8f7d\u5165\u751f\u7269\u533b\u5b66\u53d1\u5c55\u53f2\u518c\u3002<\/p>\n


<\/p>\n

\u738b\u6653\u4e1c\uff08\u5317\u751f\u6240\u6240\u957f\uff09<\/strong>\uff1a\u6211\u5bf9\u4eca\u5e74\u751f\u7406\u6216\u533b\u5b66\u5956\u7684\u89e3\u8bfb\uff0cHonjo\u7684\u53d1\u73b0\u548c\u6297\u764c\u836f\u7269\u65e0\u5173\uff0cAllison\u7684\u53d1\u73b0\u65e0\u6cd5\u89e3\u91ca\u4e3a\u5565PD-1\u5982\u6b64\u91cd\u8981\u3002\u4f46\u4e24\u4eba\u5f97\u5956\u7684\u771f\u6b63\u539f\u56e0\u662fPD-1\u6297\u4f53\u662f\u795e\u836f\u3002\u800c\u4ece\u7406\u8bba\u5230\u5b9e\u8df5\u628aPD-1\u6297\u4f53\u63a8\u5230\u73b0\u5728\u7684\u662f\u9648\u5217\u5e73\u3002<\/p>\n

 <\/p>\n

\u738b\u4fca\uff08\u8036\u9c81\u5927\u5b66\uff09<\/strong>\uff1a\u606d\u559cAllison\u548cHonjo\uff0c\u4ed6\u4eec\u90fd\u662f\u514d\u75ab\u9886\u57df\u7684\u5148\u9a71\u3002Allison codiscovered TCR, Honjo \u8fd8\u662fAID\u7684\u53d1\u73b0\u8005\u3002\u800c\u9648\u6559\u6388\u662f\u80bf\u7624\u514d\u75ab\u9886\u57df\u7684\u5148\u9a71\uff0c\u7ed9\u80bf\u7624\u514d\u75ab\u514d\u75ab\u8c03\u8282\u5206\u5b50\u7684\u5956\u4e0d\u7ed9\u9648\u6559\u6388\uff0c\u662f\u8bfa\u5956\u59d4\u5458\u4f1a\u7684\u91cd\u5927\u5931\u8bef\u3002\u5f53\u5e74TLR\u7684\u5956\u6f0f\u6389\u4e86\u540c\u5728\u8036\u9c81\u7684Ruslan, DNA \u7ed3\u6784\u7684\u5956\u6f0f\u6389\u4e86\u5973\u6027\u79d1\u5b66\u5bb6Franklin\uff08\u7f16\u8005\u6ce8\uff1aFranklin\u56e0\u5375\u5de2\u764c\u4e8e1958\u5e74\u8fc7\u4e16\uff0c\u800c\u56e0DNA\u53cc\u87ba\u65cb\u7ed3\u6784\u83b7\u5956\u7684\u65f6\u95f4\u4e3a1962\u5e74\uff09\uff0c\u4ed6\u4eec\u7684\u8d21\u732e\u503c\u5f97\u79f0\u9053\u3002<\/p>\n

 <\/p>\n

A\u6559\u6388<\/strong>\uff1a\u9648\u5217\u5e73\u7684\u786e\u662f\u57281999\u5e74\u53d1\u73b0\u4e86B7-H1\u3002\u4f46\u4ed6\u7684\u5de5\u4f5c\u6709\u4e24\u70b9\u95ee\u9898\u3002\uff081\uff09\u4ed6\u5f53\u65f6\u4e0d\u77e5\u9053\u8fd9\u662fPD-L1\uff0c\u4e0d\u77e5\u9053B7-H1\u4e0ePD1\u6709\u76f8\u4e92\u4f5c\u7528\uff1b\uff082\uff09\u4ed6\u72af\u4e86\u4e00\u4e2a\u9519\u8bef\uff0c\u8ba4\u4e3aB7-H1\u662f\u523a\u6fc0T\u7ec6\u80de\u7684\uff0c\u8fd9\u5c31\u5c06\u7814\u7a76\u5f15\u4e0a\u4e86\u5c94\u8def\u3002\u6240\u4ee5\uff0c\u9886\u57df\u91cc\u7684\u4eba\u4e0d\u8ba4\u4e3a\u4ed6\u53d1\u73b0\u4e86PD-L1\u662f\u6709\u539f\u56e0\u7684\u3002<\/p>\n

 <\/p>\n

2. Freeman\u57282000\u5e74\u7279\u5730\u53bb\u5bfb\u627ePD1\u7684\u914d\u4f53\uff0c\u4ece\u800c\u627e\u5230\u4e86PD-L1\u3002\u4ed6\u8bc1\u660e\u4e86PD-L1\u4e0ePD1\u6709\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u4e14\u8bc1\u660e\u4e86PD-L1\u5bf9T\u7ec6\u80de\u7684\u6291\u5236\u4f5c\u7528\u3002\u8fd9\u7bc7\u6587\u7ae0\u5176\u5b9e\u662fFreeman\u4e3a\u7b2c\u4e00\u4f5c\u8005\uff0cHonjo\u4e3a\u901a\u8baf\u4f5c\u8005\u3002\u6211\u4f30\u8ba1Freeman\u5f53\u65f6\u662f\u5c0f\u6559\u6388\uff0c\u521a\u5f00\u59cb\u8fdb\u5165PD1\u7684\u9886\u57df\uff0c\u800cHonje\u5df2\u7ecf\u662fPD1\u9886\u57df\u7684\u5927\u725b\u4e86\u3002\u6240\u4ee5Freeman\u627e\u5230PD-L1\u7684\u514b\u9686\u540e\uff0c\u4e0eHonje\u5408\u4f5c\uff0c\u8bc1\u660e\u4e86PD-L1\u7684\u529f\u80fd\u3002<\/p>\n

 <\/p>\n

3. 2001\u5e74\uff0cFreeman\u592b\u5987\u514b\u9686\u4e86PD-L2.<\/p>\n

 <\/p>\n

B\u6559\u6388\uff1a<\/strong>\u9648\u5217\u5e731999\u5e74\u7684paper\u8ba4\u4e3aB7H1\u662f\u523a\u6fc0T\u7ec6\u80de\u589e\u6b96\u7684\uff0c\u6b63\u597d\u8ddfPD-L1\u7684\u6291\u5236\u4f5c\u7528\u76f8\u53cd\uff0c\u8f93\u7ed9\u4e86Freeman\/Honjo\u7684JEM\u6b63\u786e\u53d1\u73b0\uff0cFreeman\u7684JEM\u7684\u90a3\u7bc7\u6587\u7ae0\u901a\u8baf\u4f5c\u8005\u662fHonjo\u3002<\/p>\n

 <\/p>\n

C\u6559\u6388\uff1a<\/strong>\u9648\u5217\u5e73\u8fd9\u7bc7clone PD-L1\u7684\u6587\u7ae0\uff0c\u6982\u5ff5\u5b8c\u5168\u6ca1\u6709\u5230\u4f4d\uff0c\u9519\u8bef\u5730\u8ba4\u4e3a\u548c\u5176\u5b83B7\u5bb6\u65cf\u4e00\u6837\uff0c\u662f\u6b63\u8c03\u63a7\u56e0\u5b50\uff0c\u8fd9\u7bc7\u6587\u7ae0\u91cc\u6ca1\u6709\u4efb\u4f55cancer\u548ctumor\u7684\u5b57\u773c\u3002<\/p>\n

 <\/p>\n

D\u6559\u6388\uff1a<\/strong>Honjo 1992\u5e74\u514b\u9686PD-1\u4e4b\u540e\u5c31\u4e00\u76f4\u8ba4\u4e3a\u662fT\u7ec6\u80de\u6d3b\u5316\u7684\u6291\u5236\u6027\u5206\u5b50\u3002Honjo 2000\u5e74\u7684\u6587\u7ae0\uff0c\u5b8c\u5168\u6b63\u786e\u7684\u6982\u5ff5\u3002\u5e76\u4e14\u660e\u786e\u6307\u51fa\u201cPD-L1 is also expressed in some cancers, as three ESTs are fromhuman ovarian tu- mors. This raises the possibility that some tumors may usePD-L1 to inhibit an antitumor immune response\u3002<\/p>\n

 <\/strong><\/p>\n

E\u6559\u6388\uff1a<\/strong>\u9648\u5217\u5e73\u662f2003\u5e74\u4e4b\u540e\u63a8\u52a8anti-PD1\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528(2006\u5e74\u5f00\u59cb\u4e34\u5e8a\u8bd5\u9a8c\uff09\uff0c\u786e\u5b9e\u6709\u5f88\u5927\u8d21\u732e\uff0c\u4f46\u4ed6\u65e0\u6cd5\u5426\u8ba4Honjo\u548cAllison\u5bf9\u4ed6\u5728\u8fd9\u65b9\u9762\u7684\u6982\u5ff5\u5f71\u54cd\u548c\u6307\u5f15\u4f5c\u7528\uff0c\u6bd5\u7adf\u4ed6\u4e4b\u524d\u60f3\u9519\u4e86\u3002<\/p>\n

 <\/p>\n

F\u6559\u6388\uff1a<\/strong>\u5bf9\u90a3\u4e2a\u65f6\u4ee3\u7814\u7a76T\u7ec6\u80de\u7684\u4eba\u6765\u8bf4\uff0c\u610f\u8bc6\u5230\u5b58\u5728\u8d1f\u8c03\u63a7T\u7ec6\u80de\u6d3b\u5316\u7684\u56e0\u5b50\uff08CTLA-4\u548cPD-1\uff09\u662f\u4e00\u4e2a\u5f88\u5927\u7684\u6982\u5ff5\u7a81\u7834\u3002\u540e\u6765\u7684\u764c\u75c7\u6cbb\u7597\u5b9e\u8df5\u4e2d\u8868\u660e\u53ea\u6709\u963b\u65adT\u7ec6\u80de\u7684\u8d1f\u8c03\u63a7\u56e0\u5b50\u624d\u80fd\u6cbb\u7597\u764c\u75c7\u3002\u8fd9\u662f\u8bfa\u8d1d\u5c14\u5956\u59d4\u5458\u4f1a\u770b\u91cd\u4e1c\u897f\uff0cfor thediscovery of cancer therapy by inhibition of negative immune regulation\u3002<\/p>\n

 <\/p>\n

\u674e\u658c\uff08\u4e0a\u6d77\u514d\u75ab\u5b66\u7814\u7a76\u6240\u526f\u6240\u957f\uff09\uff1a<\/strong>\u6211\u4e2a\u4eba\u89c9\u5f97\u8bfa\u8d1d\u5c14\u5956\u7684\u7279\u70b9\u662f\u8981\u8ba9\u4e0a\u7684\u6ca1\u4e89\u8bae\uff0c\u6ca1\u4e0a\u7684\u4e0d\u52a0\u8bc4\u8bba\uff0c\u5c06\u6765\u7684\u79d1\u5b66\u53f2\u5bb6\u4f1a\u6709\u5ba2\u89c2\u5224\u65ad\uff0c\u6211\u4eec\u8981\u5411\u524d\u770b\u3002\u5f53\u524d\uff0c\u5c3d\u7ba1\u57fa\u4e8e\u6297\u4f53\u7684\u4e34\u5e8a\u6cbb\u7597\u5c3d\u7ba1\u6709\u5f88\u5927\u7a81\u7834\uff0c\u4f9d\u7136\u6709\u5f88\u591a\u75c5\u4eba\u5e76\u4e0d\u80fd\u53d7\u76ca\u4e8e\u8fd9\u4e9b\u6297\u4f53\u6cbb\u7597\uff0c\u751a\u81f3\u6709\u5c11\u6570\u75c5\u4eba\u7531\u4e8e\u672a\u77e5\u539f\u56e0\u4f1a\u5bfc\u81f4\u80bf\u7624\u8fdb\u5c55\u52a0\u901f\uff0c\u673a\u5236\u4e0d\u6e05\u3002\u57fa\u4e8e\u6297\u4f53\u7684\u6297\u80bf\u7624\u514d\u75ab\u83b7\u5f97\u4e86\u8bfa\u8d1d\u5c14\u5956\uff0c\u8fd9\u5bf9\u63a8\u52a8\u6297\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u662f\u4e00\u4ef6\u5927\u597d\u4e8b\u3002\u6211\u63a8\u6d4b\u57fa\u4e8e\u7ec6\u80de\u4e3a\u8f7d\u4f53\u7684\u6297\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u8fd8\u4f1a\u53e6\u5916\u6709\u673a\u4f1a\u83b7\u5956\uff0c\u4e0d\u8fc7\u8fd8\u9700\u8981\u66f4\u591a\u7684\u57fa\u7840\u539f\u521b\u548c\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n

 <\/p>\n

\u5a04\u5b9e\uff08Hope Medicine inc.\uff0cCo-Founder & COO<\/span>\uff09\uff1a<\/strong>\u4e89\u8bba\u8be5\u4e0d\u8be5\u5f97\u8bfa\u5956\uff0c\u5b9e\u9645\u4e0a\u4e8e\u8d21\u732e\u5173\u7cfb\u4e0d\u5927\uff0c\u4e89\u7684\u662f\u8bdd\u8bed\u6743\uff0c\u662f\u8ba4\u53ef\uff0c\u662f\u6743\u5a01\u6027\uff01\u4f46\u8bfa\u5956\u7684\u6743\u5a01\u6027\u662f\u8001\u8bfa\u8d1d\u5c14\u548c\u59d4\u5458\u4f1a\u7ed9\u7684\uff0c\u4e0d\u662f\u7f51\u4e0a\u6295\u7968\u5f97\u51fa\u7684\u3002\u8fd9\u6b21\u8bfa\u5956\u7ed9\u4e86\u79d1\u5b66\u5bb6\uff0cimmunologists \u8ba4\u53ef\u80af\u5b9a\uff0c\u503c\u5f97\u5305\u62ec\u9648\u5217\u5e73\u6559\u6388\u5728\u5185\u7684\u6240\u6709\u4ece\u4e1a\u4eba\u58eb\u5171\u540c\u5e86\u795d\u3002\u4e5f\u66f4\u5e94\u8be5\u611f\u8c22\u9ed8\u9ed8\u652f\u6301\u4ed8\u51fa\u4e86\u5f88\u591a\u771f\u91d1\u767d\u94f6\u7684Sponsors, \u5305\u62ec\u65e5\u672c\u653f\u5e9c\u548c\u7f8e\u56fd\u653f\u5e9c\u51e0\u5341\u5e74\u5728\u8fd9\u4e00\u9886\u57df\u7684\u6295\u5165\u3002\u83b7\u76ca\u7684\u662f\u5168\u4eba\u7c7b\uff0c\u662f\u533b\u5b66\uff0c\u662f\u80bf\u7624\u79d1\u5b66\u7814\u7a76\u548c\u5b9e\u8df5\u3002\u9648\u5217\u5e73\u6559\u6388\u662f\u7f8e\u56fd\u57f9\u517b\u7684\u79d1\u5b66\u5bb6\uff0c\u4ed6\u7684\u6240\u6709\u7814\u7a76\u90fd\u662f\u5728\u7f8e\u56fd\u5b66\u4e60\u3001\u5f00\u5c55\u3001\u53d1\u8868\u7684\uff01\u4ed6\u591a\u6b21\u56de\u56fd\uff0c\u5374\u90fd\u662f\u94e9\u7fbd\u800c\u5f52\uff01\u8fd9\u624d\u662f\u503c\u5f97\u53cd\u601d\u7684\u3002\u4e00\u5206\u8015\u8018 \u4e00\u5206\u6536\u83b7\uff0c\u5728\u8fd9\u9886\u57df\uff0c\u4e2d\u56fd\u8d21\u732e\u4e86\u591a\u5c11\uff0c\u652f\u6301\u4e86\u9648\u5217\u5e73\u591a\u5c11\uff1f\u73b0\u5728\u5c31\u8c08\u8ba4\u53ef\uff0c\u8c08\u516c\u5e73\uff0c\u6ca1\u5230\u65f6\u5019\u3002\u4e2d\u56fd\u4eca\u5929\u8d77\u6b65\u652f\u6301\u4e5f\u4e0d\u665a\uff0c\u4e5f\u4e0d\u662f\u4e00\u4e2a\u9648\u5217\u5e73\uff0c\u662f\u6574\u4e2a\u9886\u57df\uff0cI\/O\uff0cimmunology, life science research! \u4eca\u5929\u4e2d\u56fd\u79d1\u5b66\u754c\u4e89\u8bfa\u5956\u8ba4\u53ef\uff0c\u4e0d\u662f\u8d21\u732e\uff0c\u8d21\u732e\u5c31\u5728\u90a3\u91cc\uff0c\u4e2d\u56fd\u8ba4\u53ef\u8db3\u591f\u4e86\uff01\u73b0\u5728\u4e89\u7684\u662f\u8bfa\u5956\u540e\u9762\u7684\u5229\u76ca\uff0c\u662f\u5965\u8fd0\u51a0\u519b\u7684\u8363\u8a89\u4ef7\u503c\uff08\u4e2d\u56fd\u5546\u4e1a\u4ef7\u503c\uff09\u3002\u4e2d\u56fd\u5bf9\u4eba\u7c7b\u547d\u8fd0\u5171\u540c\u4f53\u7684\u8d21\u732e\u5728\u8def\u4e0a\uff0c\u4e2d\u56fd\u7684\u8d21\u732e\u4e5f\u4e00\u5b9a\u4f1a\u5f97\u5230\u56fd\u9645\u793e\u4f1a\u7684\u8ba4\u53ef\uff0c\u4f46\u9700\u5047\u4ee5\u65f6\u65e5\uff01\u4eca\u5929\u7684\u5e74\u8f7b\u79d1\u5b66\u5bb6\uff0c\u5982\u679c\u80fd\u50cf\u5217\u5e73\u4e00\u6837\uff0c\u51e0\u5341\u5e74\u5982\u4e00\u65e5\uff0c\u94bb\u7814\u79d1\u5b66\uff0c\u7814\u7a76\u75be\u75c5\uff0c\u51e0\u5341\u5e74\u540e\uff0c\u4f55\u6101\u65e0\u8d21\u732e\uff0c\u4f55\u6101\u4e0d\u5f97\u5956\uff1f\u5176\u5b9e\uff0c\u5956\u5f88\u591a\uff0c\u8ba4\u53ef\u4e5f\u5f88\u591a\uff0c\u8bfa\u5956\u53ea\u662f\u5176\u4e00\uff01<\/span>\u3002<\/p>\n

 <\/p>\n

\u8bfa\u5956\u59d4\u5458\u4f1a\u5728\u8bb0\u8005\u95ee\u7b54\u65f6\u56de\u590d<\/strong>\uff1a\u5728\u80bf\u7624\u514d\u75ab\u9886\u57df\uff0c\u505a\u51fa\u91cd\u8981\u8d21\u732e\u7684\u5b66\u8005\u8fd8\u6709\u5f88\u591a\uff0c\u4f46Allison\u548cHonjo\u7684\u8d21\u732e\u4ece\u4ed6\u4eec\u4e2d\u8131\u9896\u800c\u51fa\u3002<\/p>\n

 <\/p>\n

\u6ce8\uff1a\u672c\u6587\u90e8\u5206\u5b66\u8005\u7684\u89c2\u70b9\u672a\u7ecf\u672c\u4eba\u786e\u8ba4\uff0c\u90e8\u5206\u5b66\u8005\u56e0\u4e3a\u540d\u5b57\u65e0\u6cd5\u6838\u5b9e\uff0c\u6240\u4ee5\u7528\u5b57\u6bcd\u4ee3\u66ff\u3002\u66f9\u96ea\u6d9b\u8001\u5e08\u7684\u89c2\u70b9\u4e3b\u8981\u6765\u81ea\u5176\u79d1\u5b66\u7f51\u535a\u6587\uff1a\u8bfa\u5956\u542f\u793a\uff1a\u5173\u6ce8\u57fa\u7840\u79d1\u5b66\u7684\u652f\u6491\u4e0e\u5f15\u9886\u4f5c\u7528\u3002<\/em><\/span><\/p>\n


<\/em><\/span><\/p>\n

\u9644\u300a\u77e5\u8bc6\u5206\u5b50\u300b\u5fae\u4fe1\u516c\u4f17\u53f7\u4e0a\u51e0\u4f4d\u8bfb\u8005\u7684\u516c\u5f00\u8bc4\u8bba\u3002<\/span><\/span><\/p>\n

\u9ec4\u5fd7\u575a\uff1a<\/strong><\/p>\n

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<\/p>\n


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\u7834\u6708\u4e4c\u68ad\uff1a<\/strong><\/p>\n

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\u58f9\u8ba1\u77e5\u957f\uff1a<\/strong><\/p>\n

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\u5f80\u671f\u7cbe\u5f69<\/span><\/strong><\/p>\n

\u4e00\u81f4\u6027\u8bc4\u4ef7\u76843\u5bb6\u4e0e3\u5e74<\/span><\/p>\n

\u7275\u7ebf\u642d\u6865  \u6821\u4f01\u643a\u624b\u5171\u540c\u63a2\u7d22\u4eba\u624d\u57f9\u517b\u65b0\u6a21\u5f0f\u4e00\u4e00\u9996\u5c4aCRA\u4eba\u624d\u57f9\u8bad\u73ed\u7eaa\u5b9e<\/span><\/a><\/p>\n

\u540c\u5fc3\u7b51\u68a6\u2014\u2014\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u4e0a\u6d77\u6821\u53cb\u4f1a\u5e74\u4f1a\u4fa7\u8bb0<\/span><\/a><\/p>\n

\u3010\u6848\u4f8b\u8bf4\u3011\u6570\u636e&\u4e34\u5e8a\u4e4b\u771f\u5b9e\u4e16\u754c\u7814\u7a76<\/span><\/a><\/p>\n

\u6211\u4eec\u7684\u6bd5\u4e1a\u5b63<\/span><\/p>\n

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