{"id":70763,"date":"2018-10-02T01:00:00","date_gmt":"2018-12-07T04:47:42","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/cffc92c660\/"},"modified":"2018-12-07T12:47:44","modified_gmt":"2018-12-07T04:47:44","slug":"cffc92c660","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/70763\/","title":{"rendered":"\u7f8e\u56fd\u6279\uff0c\u6b27\u76df\u62d2\u7684\u6765\u90a3\u66ff\u5c3c\uff08neratinib\uff09\u76f4\u63a5\u5728\u6211\u56fd\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7"},"content":{"rendered":"
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\"\u7f8e\u56fd\u6279\uff0c\u6b27\u76df\u62d2\u7684\u6765\u90a3\u66ff\u5c3c\uff08neratinib\uff09\u76f4\u63a5\u5728\u6211\u56fd\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\"<\/p>\n

1.\u6765\u90a3\u66ff\u5c3c\u7247\uff08neratinib<\/span>\uff09\uff0c\u8fdb\u53e3\u5316\u836f\u4e0a\u5e02\u7533\u8bf7\u57282018\u5e749\u670829\u65e5\u83b7\u5f97CDE\u53d7\u7406\u516c\u793a\u3002<\/p>\n


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\"\u7f8e\u56fd\u6279\uff0c\u6b27\u76df\u62d2\u7684\u6765\u90a3\u66ff\u5c3c\uff08neratinib\uff09\u76f4\u63a5\u5728\u6211\u56fd\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\"<\/p>\n


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2.CANbridge \uff08\u5317\u6d77\u5eb7\u6210\uff09has licensed the exclusive rights to develop and commercialize NERLYNX (neratinib) in China, Taiwan, Hong Kong and Macao (collectively, greater China) from Puma Biotechnology, Inc. (Nasdaq: PBYI).<\/p>\n


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\"\u7f8e\u56fd\u6279\uff0c\u6b27\u76df\u62d2\u7684\u6765\u90a3\u66ff\u5c3c\uff08neratinib\uff09\u76f4\u63a5\u5728\u6211\u56fd\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\"<\/p>\n


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3.\u5728\u7f8e\u56fd\u6279\u51c6\u7684\u9002\u5e94\u75c7\uff1a<\/p>\n

NERLYNX\u00ae (neratinib) is a once-daily oral medicine for women who have just finished trastuzumab therapy (i.e., Herceptin\u00ae) following surgery for early-stage breast cancer.<\/p>\n


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\"\u7f8e\u56fd\u6279\uff0c\u6b27\u76df\u62d2\u7684\u6765\u90a3\u66ff\u5c3c\uff08neratinib\uff09\u76f4\u63a5\u5728\u6211\u56fd\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\"<\/p>\n


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NERLYNX is the first HER-2 targeted treatment approved by the FDA to further reduce the risk of recurrence after Herceptin. \uff08\u65e9\u671f\u3001HER2\u9633\u6027\u3001\u672f\u540e\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u7ed9\u5b58\u5728\u9ad8\u5371\u98ce\u9669\u7684\u4e73\u817a\u764c\u60a3\u8005\u7684\u5f3a\u5316\u6cbb\u7597\u63d0\u4f9b\u65b0\u7684\u9009\u62e9<\/span>\uff09<\/p>\n

\"\u7f8e\u56fd\u6279\uff0c\u6b27\u76df\u62d2\u7684\u6765\u90a3\u66ff\u5c3c\uff08neratinib\uff09\u76f4\u63a5\u5728\u6211\u56fd\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\"<\/p>\n


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4.\u836f\u7269\u5f00\u53d1\u5386\u53f2\uff1a<\/p>\n

Neratinib was discovered and initially developed by Wyeth; Pfizer continued development up to Phase III in breast cancer, and licensed it to Puma Biotechnology in 2011.\uff08\u60e0\u6c0f\u5f00\u53d1\uff0c\u540e\u671f\u8f6c\u7ed9\u5f6a\u9a6c\u751f\u6280\uff09<\/p>\n


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In July 2017 it was approved by the US FDA for adjuvant treatment of adult patients with early stage HER2-overexpressed\/amplified breast cancer, (after adjuvant trastuzumab-based therapy).\uff08\u7f8e\u56fd\u6279\uff09<\/p>\n


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In January 2018 an EMA committee gave a negative review to neratinib.\uff08\u6b27\u76df\u62d2\uff09<\/p>\n


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5.\u770b\u770b\u6211\u56fdCDE\u5982\u4f55\u8bc4\u5b9a\u8fd9\u6b3e\u80bf\u7624\u836f\u7269\u7684\u53d7\u76ca\u548c\u98ce\u9669\u3002\u76f4\u63a5\u5229\u7528\u6d77\u5916\u4e34\u5e8a\u6570\u636e\uff0c\u52a0\u901f\u5ba1\u8bc4\u5e94\u8be5\u4ec5\u9650\u4e8e\u771f\u7684\u4e34\u5e8a\u5b66\u9700\u8981\u7684\u4ea7\u54c1\uff01<\/p>\n


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\u53c2\u8003\uff1a<\/span><\/p>\n

https:\/\/nerlynx.com\/about-nerlynx\uff1b<\/span><\/p>\n

http:\/\/www.canbridgepharma.com\/index\/productdetail\/5\uff1b<\/span><\/p>\n

https:\/\/www.drugbank.ca\/drugs\/DB11828\uff1b<\/span><\/p>\n

https:\/\/en.wikipedia.org\/wiki\/Neratinib\uff1b<\/span><\/p>\n

https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/208051s000lbl.pdf\uff1b<\/span><\/p>\n

https:\/\/endpts.com\/puma-shares-tank-after-chmp-looks-ready-to-hit-a-red-light-on-neratinib\/\uff1b<\/span><\/p>\n

\u5f80\u671f\u7cbe\u5f69<\/span><\/strong><\/p>\n

\u4e00\u81f4\u6027\u8bc4\u4ef7\u76843\u5bb6\u4e0e3\u5e74<\/span><\/p>\n

\u7275\u7ebf\u642d\u6865  \u6821\u4f01\u643a\u624b\u5171\u540c\u63a2\u7d22\u4eba\u624d\u57f9\u517b\u65b0\u6a21\u5f0f\u4e00\u4e00\u9996\u5c4aCRA\u4eba\u624d\u57f9\u8bad\u73ed\u7eaa\u5b9e<\/span><\/a><\/p>\n

\u540c\u5fc3\u7b51\u68a6\u2014\u2014\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u4e0a\u6d77\u6821\u53cb\u4f1a\u5e74\u4f1a\u4fa7\u8bb0<\/span><\/a><\/p>\n

\u3010\u6848\u4f8b\u8bf4\u3011\u6570\u636e&\u4e34\u5e8a\u4e4b\u771f\u5b9e\u4e16\u754c\u7814\u7a76<\/span><\/a><\/p>\n

\u6211\u4eec\u7684\u6bd5\u4e1a\u5b63<\/span><\/p>\n

\u91cd\u9022\u90a3\u4e9b\u76f8\u4f34\u8d70\u8fc7\u9752\u6625\u7684\u4eba\u2014\u201488\u7ea7\u8fdb\u682130\u5e74\u805a\u4f1a\u7eaa\u5b9e<\/span><\/a>
<\/span><\/p>\n


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1.\u6765\u90a3\u66ff\u5c3c\u7247\uff08neratinib\uff09\uff0c\u8fdb\u53e3\u5316\u836f\u4e0a\u5e02\u7533\u8bf7\u57282018\u5e749\u670829\u65e5\u83b7\u5f97CDE\u53d7\u7406\u516c\u793a\u3002 2.CANb […]<\/p>\n","protected":false},"author":1,"featured_media":70764,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/70763"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=70763"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/70763\/revisions"}],"predecessor-version":[{"id":70770,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/70763\/revisions\/70770"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/70764"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=70763"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=70763"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=70763"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}