{"id":71180,"date":"2018-11-16T01:00:00","date_gmt":"2018-12-07T04:52:54","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/dcbdcfa8c0\/"},"modified":"2018-12-07T12:52:57","modified_gmt":"2018-12-07T04:52:57","slug":"dcbdcfa8c0","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/71180\/","title":{"rendered":"Imfinzi\u5355\u836f\/\u8054\u7528\u4e00\u7ebf\u80ba\u764cOS\u6539\u5584\u540c\u6837\u672a\u8fbe\u7ec8\u70b9\uff0cMYSTIC"},"content":{"rendered":"
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\"Imfinzi\u5355\u836f\/\u8054\u7528\u4e00\u7ebf\u80ba\u764cOS\u6539\u5584\u540c\u6837\u672a\u8fbe\u7ec8\u70b9\uff0cMYSTIC\"<\/p>\n

#PD-L1<\/span><\/strong>
<\/p>\n

\n
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<\/p>\n

\u53bb\u5e747\u6708\u4efd<\/p>\n

AstraZeneca\u516c\u5e03\u4e86<\/p>\n

\u65d7\u4e0bMYSTIC\u4e34\u5e8a\u7814\u7a76\u521d\u6b65\u7ed3\u679c<\/p>\n

Durvalumab\u5355\u836f\/\u8054\u7528Tremelimumab<\/p>\n

\u5bf9\u6bd4<\/p>\n

\u94c2\u7c7b\u5316\u7597\u6807\u51c6\u65b9\u6848<\/p>\n

\u4e00\u7ebf\u6cbb\u7597<\/span>PD-L1\u226525%<\/p>\n

IV\u671f\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/p>\n

\u9996\u8981\u7814\u7a76\u7ec8\u70b9PFS\u672a\u8fbe\u6210
<\/p>\n

\u4f46\u662fOS\u7814\u7a76\u8fd8\u5c06\u7ee7\u7eed<\/p>\n

\u9884\u671f\u53ef\u4ee5\u5728\u4e0a\u534a\u5e74\u7ed9\u51fa\u7ed3\u679c<\/p>\n


<\/p>\n

\"Imfinzi\u5355\u836f\/\u8054\u7528\u4e00\u7ebf\u80ba\u764cOS\u6539\u5584\u540c\u6837\u672a\u8fbe\u7ec8\u70b9\uff0cMYSTIC\"<\/p>\n


<\/p>\n

\u5230\u4e86\u5e74\u521d<\/p>\n

AZ\u5c06OS\u7ed3\u679c\u66f4\u65b0\u65f6\u95f4<\/p>\n

\u63a8\u8fdf\u81f3\u4e8c\u5b63\u5ea6<\/p>\n

\u4eca\u5929<\/p>\n

AZ\u516c\u5e03\u4e86\u6700\u65b0\u7684OS\u7ed3\u679c<\/p>\n

Imfinzi\u5355\u836f\u65b9\u6848<\/strong><\/p>\n

HR=0.76<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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(97.54% CI 0.564-1.019; p=0.036<\/span>)<\/p>\n

Imfinzi\u8054\u5408Treme\u65b9\u6848<\/strong>
<\/p>\n

HR=0.85<\/p>\n

(98.77% CI 0.611-1.173; p=0.202<\/span>)<\/p>\n


<\/p>\n

\n
\n
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\u201c<\/span><\/p>\n
<\/section>\n<\/section>\n
\n

We are encouraged to see that Imfinzi monotherapy activity is in-line with that of the anti-PD-1 class in previously-untreated patients with Stage IV non-small cell lung cancer; however, we are disappointed that these results missed statistical significance. We remain confident in Imfinzi as the cornerstone of our IO programme<\/strong> and continue to evaluate its potential in ongoing non-small cell lung cancer trials, including Imfinzi and Imfinzi plus tremelimumab in combination with chemotherapy.<\/span><\/p>\n

\u2014\u2014Sean Bohen<\/span><\/strong><\/p>\n

Executive Vice President, Global Medicines Development and Chief Medical Officer<\/span><\/p>\n<\/section>\n

\n
<\/section>\n

\u201d<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\"Imfinzi\u5355\u836f\/\u8054\u7528\u4e00\u7ebf\u80ba\u764cOS\u6539\u5584\u540c\u6837\u672a\u8fbe\u7ec8\u70b9\uff0cMYSTIC\"<\/p>\n


<\/p>\n

\u6700\u521d\u7684\u9996\u8981\u7ec8\u70b9\u4ec5\u4e3aPFS<\/p>\n

\u540e\u7eed\u52a0\u5165OS\u4f5c\u4e3a\u5171\u540c\u9996\u8981\u7ec8\u70b9<\/p>\n

\u53e6\u5916\u8fd8\u6709PD-L1+-\u6307\u6807<\/p>\n

\u8fd9\u4e2a\u5e94\u8be5\u5c31\u662f\u8fd9\u6837\u4e86<\/p>\n

\u63a5\u4e0b\u6765<\/p>\n

\u56db\u5b63\u5ea6\u8fd8\u6709NEPTUNE\u4e34\u5e8a<\/p>\n

\u8fd9\u4e2aExpansion<\/p>\n

\u80fd\u7ed9\u51fa\u600e\u4e48\u6837\u7684\u7ed3\u679c<\/p>\n

\u671f\u5f85<\/p>\n


<\/p>\n\n\n\n\n<\/colgroup>\n\n\n\n\n\n
\n

Trials<\/span><\/p>\n<\/td>\n

\n

Experimental<\/span><\/p>\n<\/td>\n

\n

Active Comparator<\/span><\/p>\n<\/td>\n<\/tr>\n

PEARL<\/span><\/td>\nImfinzi monotherapy<\/span><\/td>\nSoC chemotherapy<\/span><\/td>\n<\/tr>\n
NEPTUNE<\/span><\/td>\nImfinzi +  tremelimumab<\/span><\/td>\nSoC chemotherapy<\/span><\/td>\n<\/tr>\n
POSEIDON<\/span><\/td>\nImfinzi +  chemotherapy
Imfinzi +  tremelimumab + chemotherapy<\/span><\/td>\n		SoC chemotherapy<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n
\u516c\u544a\u8fd8\u6709\u4e00\u53e5
<\/p>\n

The data support further analysis<\/em><\/p>\n

in the exploratory subgroups<\/em><\/p>\n


<\/p>\n

\n


<\/p>\n

\u4ee5\u4e0b\u4e3a\u5e7f\u544a\u5185\u5bb9<\/span><\/p>\n

\n

\u9274\u4e8e\u6b64\u524d\u516c\u76ca\u6350\u52a9\u91d1\u989d\u8f83\u5c11\uff0c\u540c\u65f6\u8003\u8651\u56e2\u961f\u8fd0\u8425\u6210\u672c\uff0c\u6211\u4eec\u5f15\u5165\u4e86\u5fae\u4fe1\u56e2\u961f\u7684\u6d41\u91cf\u4e3b\u529f\u80fd\uff0c\u6309\u7167\u5176\u5206\u6210\u89c4\u5219\uff0c\u6211\u4eec\u53ef\u4ee5\u83b7\u5f97\u5176\u5e7f\u544a\u6536\u5165\u7684<\/span>\u4e94\u6210\u5de6\u53f3\uff0c\u867d\u7136\u8fd9\u4e5f\u662f\u4e00\u4e2a\u6bd4\u8f83\u4f4e\u7684\u6570\u5b57\uff0c\u4f46\u5374\u9ad8\u4e8e\u4ee5\u5f80\u7684\u516c\u76ca\u6350\u52a9\u91d1\u989d\u3002<\/span><\/p>\n

\u8003\u8651\u5230\u8fd9\u53ef\u80fd\u7ed9\u60a8\u5e26\u6765\u9605\u8bfb\u4f53\u9a8c\u7684\u4e0b\u964d\uff0c\u6211\u4eec\u5bf9\u6b64\u6df1\u8868\u9057\u61be\uff0c\u5e0c\u671b\u60a8\u53ef\u4ee5\u7406\u89e3\uff1b\u540c\u65f6\u5982\u679c\u60a8\u8ba4\u4e3a\u6587\u672b\u51fa\u73b0\u7684\u67d0\u4e9b\u5e7f\u544a\u5bf9\u60a8\u6784\u6210\u4fb5\u6743\u6216\u662f\u9a9a\u6270\u7b49\uff0c\u8bf7\u7acb\u5373\u70b9\u51fb\u94fe\u63a5\u4e0a\u62a5\u7ed9\u5fae\u4fe1\u56e2\u961f\u3002<\/span><\/p>\n

\u5f53\u7136\uff0c\u5728\u5e73\u8861\u7528\u6237\u9605\u8bfb\u4f53\u9a8c\u548c\u56e2\u961f\u8fd0\u8425\u6210\u672c\u65f6\uff0c\u6211\u4eec\u4f1a\u6beb\u4e0d\u72b9\u8c6b\u7684\u4f18\u5148\u8003\u8651\u7528\u6237\u9605\u8bfb\u4f53\u9a8c\uff0c\u5e76\u5c06\u5bf9\u6b64\u4f5c\u51fa\u8c03\u6574\u3002\u5982\u679c\u60a8\u89c9\u5f97\u6587\u672b\u5e7f\u544a\u5df2\u7ecf\u5f71\u54cd\u5230\u4e86\u60a8\u7684\u9605\u8bfb\u4f53\u9a8c\uff0c\u8bf7\u968f\u65f6\u544a\u77e5\u6211\u4eec\u3002<\/span><\/p>\n

\u6700\u540e\uff0c\u975e\u5e38\u611f\u8c22\u60a8\u957f\u4e45\u4ee5\u6765\u7684\u5173\u6ce8\u548c\u652f\u6301\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

#PD-L1 \u53bb\u5e747\u6708\u4efd AstraZeneca\u516c\u5e03\u4e86 \u65d7\u4e0bMYSTIC\u4e34\u5e8a\u7814\u7a76\u521d\u6b65\u7ed3\u679c Durvalumab […]<\/p>\n","protected":false},"author":1,"featured_media":71181,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/71180"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=71180"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/71180\/revisions"}],"predecessor-version":[{"id":71185,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/71180\/revisions\/71185"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/71181"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=71180"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=71180"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=71180"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}