{"id":71229,"date":"2018-11-05T01:00:00","date_gmt":"2018-12-07T04:53:31","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/83eb1b6070\/"},"modified":"2018-12-07T12:53:34","modified_gmt":"2018-12-07T04:53:34","slug":"83eb1b6070","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/71229\/","title":{"rendered":"BMS\u4e0eInfinity\u5408\u4f5c\u63a8\u8fdbNivo\u8054\u5408IPI-549\u5c3f\u8def\u4e0a\u76ae\u764c\u4e34\u5e8a"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section style=\"max-width: 100%;box-sizing: border-box;color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-right: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;line-height: 1.6;word-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 0.8em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);border-width: 0px;border-style: initial;border-color: initial;text-align: center;word-wrap: break-word !important;\"><\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"color: rgb(251, 188, 5);\">#PD-1<\/span><\/strong><br  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-right: 22px;padding-left: 22px;max-width: 100%;box-sizing: border-box;line-height: 1.6;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u4eca\u5929BMS\u4e0eInfinity\u8054\u5408\u5ba3\u5e03<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u5408\u4f5c\u5f00\u5c55Nivolumab\u8054\u5408IPI-549<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u4e34\u5e8a\u7814\u7a76<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u5373<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u94c2\u7c7b\u65b9\u6848\u6cbb\u7597\u8fdb\u5c55\u7684\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c<\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: center;overflow-wrap: break-word !important;\">Nivolumab\u4e3a\u5df2\u7ecf\u83b7\u6279\u7684\u4e8c\u7ebf\u6cbb\u7597\u4ea7\u54c1<\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: center;overflow-wrap: break-word !important;\">IPI-549\u4e3a\u552f\u4e00\u7684\u4e34\u5e8a\u5728\u7814PI3K-\u03b3\u9009\u62e9\u6027\u6291\u5236\u5242<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><br  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u8be5\u7814\u7a76\u4ee3\u53f7MARIO-275<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u4e34\u5e8aII\u671f\u8bd5\u9a8c<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u8ba1\u5212\u62db\u52df150\u4f4d\u53d7\u8bd5\u8005<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u8bd5\u9a8c\u5206\u4e3aNivo+IPI-549\/Nivo\u5355\u836f\u7ec4<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u9996\u8981\u7814\u7a76\u7ec8\u70b9\u4e3aORR<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u5305\u62ec<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u6240\u6709\u60a3\u8005\u4ee5\u53ca\u4e0d\u540cMDSCs\u7684\u57fa\u7ebf\u6c34\u5e73\u4e9a\u7ec4<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><br  \/><\/p>\n<section class=\"xmt-style-block\"   >\n<section class=\"KolEditor\" style=\"border-width: 0px;border-style: none;border-color: initial;padding: 0px;\">\n<section class=\"Powered-by-KolEditor V5\" style=\"box-sizing: border-box;\" >\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section class=\"\" style=\"padding-bottom: 1.2em;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;line-height: 1em;height: 1em;margin-top: -0.5em;box-sizing: border-box;\"><span style=\"display: inline-block;vertical-align: top;font-size: 80px;line-height: 1em;color: rgb(192, 200, 209);box-sizing: border-box;\">\u201c<\/span> <\/p>\n<section style=\"width: 4em;border-bottom: 1px solid rgb(192, 200, 209);display: inline-block;vertical-align: middle;margin-top: 1.6em;margin-left: -0.6em;box-sizing: border-box;\"><\/section>\n<\/section>\n<section class=\"\" style=\"margin-top: -0.5em;padding: 10px;box-sizing: border-box;\">\n<section class=\"Powered-by-KolEditor V5\" style=\"box-sizing: border-box;\" >\n<section class=\"\" style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"text-align: center;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;text-align: left;\"><em><span style=\"font-size: 14px;\">The expansion of our relationship with Infinity underscores our efforts to follow the science and support potential novel combination therapies in immuno-oncology for cancer patients with limited treatment options. Our goal is to determine whether targeting the tumor microenvironment with IPI-549 will enhance the activity of Opdivo for people with urothelial cancer and potentially in other tumor types where MDSCs suppress the immune response.<\/span><\/em><\/section>\n<section style=\"box-sizing: border-box;text-align: right;\"><strong><span style=\"color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);font-size: 16px;\">Fouad Namouni, M.D.<\/span><\/strong><\/section>\n<section style=\"box-sizing: border-box;text-align: right;\"><span style=\"background-color: rgb(255, 255, 255);font-size: 14px;color: rgb(136, 136, 136);\">Head of Oncology Development, Bristol-Myers Squibb<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;height: 1em;float: right;line-height: 1;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 4em;border-bottom: 1px solid rgb(192, 200, 209);box-sizing: border-box;\"><\/section>\n<p><span style=\"display: inline-block;vertical-align: top;font-size: 80px;margin-top: -0.11em;margin-left: -0.1em;color: rgb(192, 200, 209);box-sizing: border-box;\">\u201d<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/3-1544158412.jpg\" alt=\"BMS\u4e0eInfinity\u5408\u4f5c\u63a8\u8fdbNivo\u8054\u5408IPI-549\u5c3f\u8def\u4e0a\u76ae\u764c\u4e34\u5e8a\" title=\"BMS\u4e0eInfinity\u5408\u4f5c\u63a8\u8fdbNivo\u8054\u5408IPI-549\u5c3f\u8def\u4e0a\u76ae\u764c\u4e34\u5e8a\"><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/1-1544158413.jpg\" alt=\"BMS\u4e0eInfinity\u5408\u4f5c\u63a8\u8fdbNivo\u8054\u5408IPI-549\u5c3f\u8def\u4e0a\u76ae\u764c\u4e34\u5e8a\" title=\"BMS\u4e0eInfinity\u5408\u4f5c\u63a8\u8fdbNivo\u8054\u5408IPI-549\u5c3f\u8def\u4e0a\u76ae\u764c\u4e34\u5e8a\"><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><br  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">CheckMate-275\u4e34\u5e8a\u4e2d<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u9ad8MDSCs\u6c34\u5e73\u60a3\u8005\u7ed9\u4e88Opdivo\u6cbb\u7597\u540e<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u603b\u751f\u5b58\u671f\u76f8\u5e94\u7f29\u77ed<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u800c\u6b64\u524d\u8054\u5408\u7684I\u671f\u4e34\u5e8aMARIO-1\u4e5f\u663e\u793a<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">IPI-549\u53ef\u4ee5\u964d\u4f4eMDSCs\u6c34\u5e73<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u4e8c\u8005\u8054\u5408\u53ef\u80fd\u4f1a\u51fa\u73b0\u534f\u540c\u673a\u5236<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-right: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;line-height: 1.6;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u514d\u75ab\u6291\u5236\u5242\u54cd\u5e94\u5f97\u5230\u63d0\u5347<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u800cMARIO-1\u4e34\u5e8a\u7ed3\u679c\u5c06\u5728\u8fd1\u671f\u516c\u5e03<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u7ee7\u7eed\u5173\u6ce8<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/2-1544158413.jpg\" alt=\"BMS\u4e0eInfinity\u5408\u4f5c\u63a8\u8fdbNivo\u8054\u5408IPI-549\u5c3f\u8def\u4e0a\u76ae\u764c\u4e34\u5e8a\" title=\"BMS\u4e0eInfinity\u5408\u4f5c\u63a8\u8fdbNivo\u8054\u5408IPI-549\u5c3f\u8def\u4e0a\u76ae\u764c\u4e34\u5e8a\"><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/0-1544158414.jpg\" alt=\"BMS\u4e0eInfinity\u5408\u4f5c\u63a8\u8fdbNivo\u8054\u5408IPI-549\u5c3f\u8def\u4e0a\u76ae\u764c\u4e34\u5e8a\" title=\"BMS\u4e0eInfinity\u5408\u4f5c\u63a8\u8fdbNivo\u8054\u5408IPI-549\u5c3f\u8def\u4e0a\u76ae\u764c\u4e34\u5e8a\"><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><br  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u514d\u75ab\u6291\u5236\u5242\u8054\u7528\u4e34\u5e8a<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u8fd8\u5728\u4e0d\u65ad\u6269\u5c55<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u671f\u5f85+<span style=\"color: rgb(62, 62, 62);font-size: 16px;text-align: center;background-color: rgb(255, 255, 255);\">PI3K-\u03b3\u7ed3\u679c<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><span style=\"color: rgb(62, 62, 62);font-size: 16px;text-align: center;background-color: rgb(255, 255, 255);\">\u7b49\u5f85\u4e34\u5e8a\u5f00\u542f<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: center;\">\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>#PD-1 \u4eca\u5929BMS\u4e0eInfinity\u8054\u5408\u5ba3\u5e03 \u5408\u4f5c\u5f00\u5c55Nivolumab\u8054\u5408IPI-549 \u7528\u4e8e\u6cbb\u7597\u665a\u671f\u5c3f [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":71230,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/71229"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=71229"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/71229\/revisions"}],"predecessor-version":[{"id":71235,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/71229\/revisions\/71235"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/71230"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=71229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=71229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=71229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}